MCID: ORC001
MIFTS: 37

Orchitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Orchitis

MalaCards integrated aliases for Orchitis:

Name: Orchitis 12 44 15 73
Inflammation of Testis 12
Orchititis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2518
ICD10 33 N45.2
MeSH 44 D009920
NCIt 50 C97145
UMLS 73 C0029191

Summaries for Orchitis

MalaCards based summary : Orchitis, also known as inflammation of testis, is related to epididymo-orchitis and granulomatous orchitis. An important gene associated with Orchitis is PROKR1 (Prokineticin Receptor 1). The drugs Isoniazid and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Orchitis /ˌɔːrˈkaɪtɪs/ or orchiditis /ˌɔːrkɪˈdaɪtɪs/ (from the Ancient Greek ὄρχις meaning \"testicle\";... more...

Related Diseases for Orchitis

Graphical network of the top 20 diseases related to Orchitis:



Diseases related to Orchitis

Symptoms & Phenotypes for Orchitis

GenomeRNAi Phenotypes related to Orchitis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.72 EPPIN
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.72 GJA3 IFNA2 EDA EPPIN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.72 GJA3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.72 EPPIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.72 GJA3 IFNA2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.72 EPPIN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.72 EPPIN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.72 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.72 EDA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.72 IFNA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.72 IFNA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.72 IFNA2 EDA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.72 EPPIN
14 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.72 EPPIN
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.72 GJA3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 EPPIN
17 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.72 EDA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.72 EDA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.72 GJA3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.72 EPPIN

Drugs & Therapeutics for Orchitis

Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2 Anti-Bacterial Agents Phase 3
3 Anti-Infective Agents Phase 3
4 Antimetabolites Phase 3
5 Antitubercular Agents Phase 3
6 Hypolipidemic Agents Phase 3
7 Lipid Regulating Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
2 Nebulized Epinephrine and Oral Dexamethasone in Bronchiolitis Not yet recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
3 Anterior Transversalis Fascia Approach Versus Preperitoneal Space Approach for Inguinal Hernia Repair in Residents Recruiting NCT02984917 Not Applicable
4 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis Active, not recruiting NCT02665182 Not Applicable

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

Genetic Tests for Orchitis

Anatomical Context for Orchitis

MalaCards organs/tissues related to Orchitis:

41
Testis, Testes, Prostate, T Cells, Bone, Lymph Node, Monocytes

Publications for Orchitis

Articles related to Orchitis:

(show top 50) (show all 641)
# Title Authors Year
1
Idiopathic granulomatous orchitis: Ultrasound and MR imaging features. ( 29415866 )
2018
2
Nonhealing scrotal ulceration-an unusual manifestation of TB epididymo-orchitis: case report and review of literature. ( 29375854 )
2018
3
Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. ( 29554185 )
2018
4
Intratesticular pseudoaneurysm secondary to orchitis: A case report. ( 29541589 )
2018
5
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
6
Non-traumatic testicular rupture following episode of epididymo-orchitis. ( 29367897 )
2018
7
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
8
Epididymo-orchitis caused by enteric organisms in men >a8835A years old: beyond fluoroquinolones. ( 29450767 )
2018
9
Testicular plasmacytoma misdiagnosed as orchitis. ( 29866662 )
2018
10
Comparison of inflammatory markers between brucella and non-brucella epididymo-orchitis. ( 29697933 )
2018
11
Granulomatous epididymo-orchitis: diagnosis by fine needle aspiration. ( 28534708 )
2017
12
Epididymo-orchitis caused by Histoplasma capsulatumin a Colombian patient. ( 29340471 )
2017
13
Patients with Epididymo-Orchitis and Meteorological Impact in Taiwan: A Nationwide Population-Based Study. ( 28316630 )
2017
14
Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. ( 28765008 )
2017
15
Neonatal epididymo-orchitis with pyocele caused by Escherichia coli: Successful treatment with antimicrobial therapy alone. ( 29224998 )
2017
16
Induction of experimental autoimmune orchitis by immunization with xenogenic testicular germ cells in mice. ( 28505516 )
2017
17
Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin. ( 28667125 )
2017
18
Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not? ( 28407803 )
2017
19
Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. ( 28761901 )
2017
20
Epididymo-orchitis causing testicular infarction: a serious complication of a common disorder. ( 29423147 )
2017
21
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. ( 28205525 )
2017
22
Testicular Metastasis From Prostatic Adenocarcinoma Presenting as Recurrent Epididymo-orchitis. ( 28760557 )
2017
23
Multiparametric ultrasound findings of tuberculous orchitis following bacillus Calmette-GuAcrin therapy. ( 29484062 )
2017
24
Coexistent duplication of urethra and a refluxing ectopic ureter presenting as recurrent epididymo-orchitis in a child. ( 28928250 )
2017
25
The 2016 European guideline on the management of epididymo-orchitis. ( 28632112 )
2017
26
Xanthogranulomatous Orchitis: Rare Case with Brief Literature Review. ( 28462167 )
2017
27
Xanthogranulomatous orchitis after blunt testicular trauma mimicking a testicular tumor: A case report and comparison with published cases. ( 28537048 )
2017
28
Retrospective review of the management of epididymo-orchitis in a London-based level 3 sexual health clinic: an audit of clinical practice. ( 28201951 )
2017
29
Filariasis Orchitis-Differential for Acute Scrotum Pathology. ( 28507911 )
2017
30
Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease. ( 29034643 )
2017
31
Inferno sign in epididymo-orchitis. ( 28647767 )
2017
32
Severe Acute Epididymo-Orchitis Complicated with Abscess and Testicular Necrosis - Case Report. ( 28246649 )
2017
33
Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report. ( 27472731 )
2016
34
Re: Epidydimo-Orchitis and Anorectal Malformations: When and in Whom? ( 27628841 )
2016
35
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
36
First description of herpes simplex virus type 1 epididymo-orchitis: A new clinical form of herpes simplex virus infection during septic shock? ( 27672563 )
2016
37
The clinical and laboratory characteristics, treatments, and outcomes of patients with Brucella epididymo-orchitis (BEO) compared to those without BEO. ( 27966338 )
2016
38
Ameliorating Effect of Ginseng on Epididymo-Orchitis Inducing Alterations in Sperm Quality and Spermatogenic Cells Apoptosis following Infection by Uropathogenic Escherichia coli in Rats. ( 27602327 )
2016
39
Syphilitic orchitis mimicking a testicular tumor in a clinically occult HIV-infected young man: a case report with emphasis on a challenging pathological diagnosis. ( 26762155 )
2016
40
Filarial Orchitis due to Wuchereria bancrofti Masquerading as Testicular Neoplasm. ( 27582521 )
2016
41
Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. ( 27246506 )
2016
42
Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons. ( 27884655 )
2016
43
ASSOCIATION OF MEAN PLATELET VOLUME AND THE MONOCYTE/LYMPHOCYTE RATIO WITH BRUCELLA-CAUSED EPIDIDYMO-ORCHITIS. ( 27405128 )
2016
44
A Case of Epididymo-orchitis after intravesical bacille Calmette-GuAcrin therapy for superficial bladder carcinoma in a patient with latent tuberculosis infection. ( 27257433 )
2016
45
Testicular infarction and rupture: an uncommon complication of epididymo-orchitis. ( 27165751 )
2016
46
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
47
Tuberculous epididymo-orchitis masquerading as acute scrotum. ( 26847806 )
2016
48
Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient. ( 27222288 )
2016
49
Pediatric granulomatous orchitis: Case report and review of the literature. ( 26669680 )
2016
50
Immune checkpoint inhibitors-related orchitis. ( 28039179 )
2016

Variations for Orchitis

Expression for Orchitis

Search GEO for disease gene expression data for Orchitis.

Pathways for Orchitis

GO Terms for Orchitis

Cellular components related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJA3 GJB6
2 connexin complex GO:0005922 8.62 GJA3 GJB6

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell communication GO:0007154 8.62 GJA3 GJB6

Sources for Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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