Orchitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Orchitis, also known as inflammation of testis, is related to granulomatous orchitis and epididymo-orchitis. An important gene associated with Orchitis is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and t cells, and related phenotype is immune system.

Wikipedia: ⁷⁵ Orchitis is inflammation of the testes. It can also involve swelling, pains and frequent infection,... more...

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Related Diseases for Orchitis

Diseases related to Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1041)

#	Related Disease	Score	Top Affiliating Genes
1	granulomatous orchitis	32.6	ZAN CD68
2	epididymo-orchitis	32.4	ZAN TEX11 IL6 CRP
3	mumps	31.4	TNF IL6 IL1B IL10
4	parotitis	31.1	CRP CD8A CD4
5	brucellosis	31.0	TNF IL6 IL10 CRP
6	testicular torsion	30.9	TNF IL1B EPPIN CRP
7	urogenital tuberculosis	30.7	CRP CD4
8	prostatitis	30.6	TNF IL6 IL1B IL10
9	syphilis	30.5	TNF CRP CD8A CD4 CCR6
10	polyarteritis nodosa	30.5	TNF IL6 IFNA2 CRP
11	azoospermia	30.4	TEX11 IL1B EPPIN CFAP47 ACE2
12	histoplasmosis	30.3	TNF CD4 CCR6
13	urinary tract infection	30.3	TNF IL6 IL1B IL10 H2AC18 CRP
14	chlamydia	30.3	TNF IL6 IL1B IL10 CRP CCL2
15	rubella	30.3	TNF IL6 IL1B IL10
16	relapsing polychondritis	30.2	TNF IL6 CRP CD4
17	nocardiosis	30.2	TNF CRP CD4
18	filariasis	30.2	TNF IL6 IL10 CD4
19	encephalitis	30.2	TNF IL6 IL1B IL10 CCL2
20	filarial elephantiasis	30.2	TNF IL10 CD8A CD4
21	spermatogenic failure, x-linked, 1	30.2	TEX11 EPPIN CFAP47
22	testicular disease	30.2	TNF IL6 H2AC18 EPPIN CD8A CD4
23	haemophilus influenzae	30.2	TNF IL1B
24	henoch-schoenlein purpura	30.2	TNF IL6 CRP CD4 CCR6
25	autoimmune disease	30.2	TNF IL6 IL1B IL10 CRP CCR6
26	typhoid fever	30.2	TNF IL6 IL1B CRP CCR6
27	epidemic typhus	30.1	IL10 CRP CD8A CD4
28	purpura	30.1	TNF IL6 IL1B IL10 CRP
29	meningitis	30.1	TNF IL6 IL1B IL10 CRP CCL2
30	paratyphoid fever	30.1	TNF IL1B CRP
31	scrub typhus	30.1	TNF IL1B IL10 CRP
32	pancreatitis	30.1	TNF IL6 IL1B IL10 CRP
33	bacteriuria	30.1	IL6 CRP CCL2
34	diverticulitis	30.1	TNF IL6 CRP CCR6
35	toxoplasmosis	30.0	TNF IL6 IL1B IL10
36	igg4-related disease	30.0	IL10 CRP CD4 CCR6
37	vasculitis	30.0	TNF IL6 IL1B IL10 IFNA2 CRP
38	tertiary syphilis	30.0	TNF IL10 CRP CD8A CD4
39	gout	30.0	TNF IL6 IL1B CRP
40	sialadenitis	30.0	TNF CD4 CCR6
41	thyroiditis	30.0	TNF IL6 IL1B IL10 CRP
42	gastroenteritis	29.9	TNF IL6 IL1B IL10 IFNA2 CRP
43	infective endocarditis	29.9	IL6 CRP CCR6
44	salmonellosis	29.9	TNF IL6 IL1B IL10 CD8A CD4
45	sleeping sickness	29.9	TNF IL10 H2AC18
46	melioidosis	29.9	TNF IL6 IL10
47	endometritis	29.9	TNF IL6 IL1B
48	interstitial nephritis	29.9	TNF CRP CD8A CD4 CCR6
49	thrombocytopenic purpura, autoimmune	29.9	IFNA2 CD8A CD4 CCR6
50	urethritis	29.9	TNF IL6 IL1B IL10 CRP CD8A

Graphical network of the top 20 diseases related to Orchitis:

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Symptoms & Phenotypes for Orchitis

GenomeRNAi Phenotypes related to Orchitis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	ACE2 CCL2 CCR6 CD4 CD68 CD8A
2	no effect	GR00402-S-2	10.18	CCL2 CCR6 CD4 CD68 CFAP47 CLDN11

MGI Mouse Phenotypes related to Orchitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.47	ACE2 CCL2 CCR6 CD4 CD68 CD8A

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Drugs & Therapeutics for Orchitis

Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibiotics, Antitubercular
2	Anti-Bacterial Agents
3	Anti-Infective Agents

Interventional clinical trials:

#	Name	Status	NCT ID
1	Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis - a Randomized Controlled Trial	Unknown status	NCT02665182
2	Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy	Unknown status	NCT03969979
3	Analgetics vs Analgetics and Antibiotics for Pediatric Clinical and Sonographic Orchitis or Epididymitis	Completed	NCT04489979
4	Prospective Observational Study on SEBBIN Silicone Gel-filled Testicular Implants	Recruiting	NCT05097820

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

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Genetic Tests for Orchitis

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Anatomical Context for Orchitis

Organs/tissues related to Orchitis:

MalaCards : Testis, Testes, T Cells, Bone Marrow, Prostate, Lymph Node, Spinal Cord

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Publications for Orchitis

Articles related to Orchitis:

(show top 50) (show all 2427)

#	Title	Authors	PMID	Year
1	Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis. ⁵³ ⁶²	Yeniyol CO...Ayder AR	10840112	2000
2	Successful interferon-alpha 2 a therapy for a patient with acute mumps orchitis. ⁵³ ⁶²	Ruther U...Jipp P	7744163	1995
3	Systemic treatment with interferon-alpha 2B: an effective method to prevent sterility after bilateral mumps orchitis. ⁵³ ⁶²	Erpenbach KH	2056606	1991
4	[Systemic alpha-interferon therapy: a possible method for prevention of testicular atrophy and permanent sterility in patients with bilateral mumps orchitis]. ⁵³ ⁶²	Erpenbach K...Derschum W	1926670	1991
5	Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion. ⁶²	Keivan M...Dadfar R	35593125	2022
6	Urological Impact of Epididymo-orchitis in Patients with Anorectal Malformation: An ARM-Net Consortium Study. ⁶²	Morandi A...Stenstrom P	35073590	2022
7	Local adrenomedullin gene delivery inhibits Leydig cell dysfunction by rescuing steroidogenic enzymes in vivo. ⁶²	Zhou JH...Hu W	35942817	2022
8	Pediatric Non-Testicular Torsion Acute Scrotum-Is the Use of Prophylactic Antibiotics in Patients With Normal Urine Analysis Justified? ⁶²	Kozar T...Dangle PP	35878814	2022
9	Torsion of the spermatic cord in adults: a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion. ⁶²	Dang VT...Khene ZE	35322657	2022
10	Tuberculosis Epididymo-Orchitis Mimicking Malignancy Resulting from Intravesical Bacillus Calmette-Guérin Immunotherapy for Bladder Cancer: A Case Report of a Rare Complication. ⁶²	Chiu LW...Chang CH	36359505	2022
11	Epididymo-orchitis secondary to colovesical fistula. ⁶²	Waack A...Patel NJ	36438455	2022
12	Clinical spectrum and management options for prostatic utricle in children. ⁶²	Gupta A...Samnakay N	35101262	2022
13	Antineutrophil cytoplasmic antibody associated vasculitis: a converging diagnosis from neuropathy and testicular infarcts. ⁶²	Mercer R...Bates C	36452284	2022
14	EPIDIDYMO-ORCHITIS LEADING TO GLOBAL TESTICULAR INFARCTION IN A PEDIATRIC PATIENT - A CASE REPORT. ⁶²	Heaney C...Rehfuss A	36450319	2022
15	Diffuse granulomatous orchitis involved the whole testis: Diagnostic clue in magnetic resonance imaging. ⁶²	Wang W...Kang Y	36435623	2022
16	Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan. ⁶²	Zhao L...Wang D	36372306	2022
17	Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis. ⁶²	Peng W...Fijak M	36434305	2022
18	Sonographic findings of COVID-19 related acute scrotal infection and associations with clinical-laboratory data. ⁶²	Aydin S...Kantarci M	35775362	2022
19	Incidental Tuberculosis Epididymitis/Epididymo-orchitis: A Retrospective Analysis at a Tertiary Center in Taiwan. ⁶²	Yang YK...Pan PY	35798186	2022
20	Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis. ⁶²	Nahas RS...Thabit AK	35912293	2022
21	Investigation of the outbreaks of abortions and orchitis in livestock in Namibia during 2016-2018. ⁶²	Samkange A...Mushonga B	36242679	2022
22	Severe Generalized Epidemic Myalgia in an Adult due to Human Parechovirus Type 3: A Case Report. ⁶²	Masuda S...Sumida C	36420236	2022
23	Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. ⁶²	Ortega-Ferrusola C...Da Silva-Alvarez E	35748405	2022
24	Is testicular microlithiasis associated with testicular pathologies in children? ⁶²	Sag S...Gungormez EK	35829746	2022
25	Testicular Plasmacytoma Masking as Epididymo-orchitis in a Known Multiple Myeloma Patient. ⁶²	Vusqa UT...Samhouri Y	36060019	2022
26	The Pseudo-Bladder: A Case of the Prostatic Urethra Masquerading as the Bladder. ⁶²	Byer J...Chamberlin JD	36179861	2022
27	Epididymo-Orchitis and Pelvic Abscess in a Patient With Inflatable Penile Prosthesis. ⁶²	Ansari M...Ganti L	36320940	2022
28	Impact of vaccine effectiveness and coverage on preventing large mumps outbreaks on college campuses: Implications for vaccination strategy. ⁶²	Melgar M...Marlow MA	35728505	2022
29	Epididymo-orchitis caused by Histoplasma capsulatum. ⁶²	Sanha V...Pasqualotto AC	35651534	2022
30	Antimicrobial peptide MPX attenuates LPS-induced inflammatory response and blood-testis barrier dysfunction in Sertoli cells. ⁶²	Zhu CL...Zhang XM	35842953	2022
31	Male Reproductive Tract Involvement and Sperm Parameters in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis. ⁶²	Kloping YP...Hakim L	36102101	2022
32	Presentations of the Acute Scrotum During the COVID-19 Pandemic: Experiences of a Non-urological Centre. ⁶²	Davis H...Allu V	36127974	2022
33	A simplified ultrasound approach to diagnose testicular torsion and predict unsalvageable testis. ⁶²	Lim Y...Min SJ	35437523	2022
34	Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level. ⁶²	Zhang D...Guo R	35962439	2022
35	Testicular Germ Cell Tumours-The Role of Conventional Ultrasound. ⁶²	Belfield J...Findlay-Line C	36010875	2022
36	Immune homeostasis and disorder in the testis - Roles of Sertoli cells. ⁶²	Chen R...Han D	35580404	2022
37	The role of a urine dipstick in the diagnosis of the acute scrotum. ⁶²	Tissot S...Grills R	35783592	2022
38	[Orchiectomy due to early syphilis]. ⁶²	Koch L...Sadoghi B	35166861	2022
39	Minor lobulation of the testis, mimicking polyorchidism when inflammed, discussion of a rare case: A case report. ⁶²	Gharib MH...Zahedpasha R	35907296	2022
40	Vasitis mimicking an inguinal hernia: A diagnostic dilemma. ⁶²	Bahadori A...Sharma P	35520032	2022
41	Newer Insights into Prostatic Utricle in Proximal Hypospadias. ⁶²	Sengar M...Gupta CR	36238343	2022
42	External Male Genitalia in Henoch-Schönlein Syndrome: A Systematic Review. ⁶²	Montorfani-Janett VML...Cristallo Lacalamita M	36010045	2022
43	Sodium-glucose cotransporter 2 inhibitor-associated severe epididymo-orchitis. ⁶²	Mishra R...Raj R	35817490	2022
44	Xanthogranulomatous orchitis: A rare case of testicular mass. ⁶²	Pattenden TA...Keller A	35586401	2022
45	COVID-19 and Genitourinary Tract: A Retrospective Study in the Tertiary Care Center. ⁶²	Gupta R...Ram Dhayal I	36017292	2022
46	Immune cell characterization in spontaneous autoimmune orchitis in dogs. ⁶²	Probstl C...Goericke-Pesch S	35633611	2022
47	Testicular exosomes disturb the immunosuppressive phenotype of testicular macrophages mediated by miR-155-5p in uropathogenic Escherichia coli-induced orchitis. ⁶²	Xu J...Zhao K	35915541	2022
48	Genetic diversity of Chlamydia pecorum detected in sheep flocks from Mexico. ⁶²	Limon-Gonzalez MM...Diaz-Aparicio E	35119684	2022
49	A short review of male genito-urinary lesions caused by coronavirus disease 2019. ⁶²	Sun X...Lyu J	36246426	2022
50	Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.). ⁶²	Elangovan A...Thilagar S	35227784	2022

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Genes for Orchitis

Genes related to Orchitis (0 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IFNA2	Interferon Alpha 2	Protein Coding	12.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10840112 2056606 1926670 (more) 7744163
2	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	9.94	DISEASES inferred ¹⁴ ¹⁴
3	CFAP47	Cilia And Flagella Associated Protein 47	Protein Coding	9.27	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
4	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	7.04	DISEASES inferred ¹⁴
5	H2AC18	H2A Clustered Histone 18	Protein Coding	7	DISEASES inferred ¹⁴ ¹⁴
6	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	6.48	DISEASES inferred ¹⁴
7	CD4	CD4 Molecule	Protein Coding	6.09	DISEASES inferred ¹⁴
8	IL6	Interleukin 6	Protein Coding	6.02	DISEASES inferred ¹⁴
9	ZAN	Zonadhesin	Protein Coding	5.99	DISEASES inferred ¹⁴
10	TNF	Tumor Necrosis Factor	Protein Coding	5.8	DISEASES inferred ¹⁴
11	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	5.76	DISEASES inferred ¹⁴ ¹⁴
12	CD8A	CD8a Molecule	Protein Coding	5.68	DISEASES inferred ¹⁴
13	CD68	CD68 Molecule	Protein Coding	5.65	DISEASES inferred ¹⁴
14	IL10	Interleukin 10	Protein Coding	5.63	DISEASES inferred ¹⁴
15	CRP	C-Reactive Protein	Protein Coding	5.57	DISEASES inferred ¹⁴
16	IL1B	Interleukin 1 Beta	Protein Coding	5.49	DISEASES inferred ¹⁴
17	CLDN11	Claudin 11	Protein Coding	5.47	DISEASES inferred ¹⁴
18	TEX11	Testis Expressed 11	Protein Coding	5.42	DISEASES inferred ¹⁴
19	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	5.37	DISEASES inferred ¹⁴
20	MFSD6	Major Facilitator Superfamily Domain Containing 6	Protein Coding	5.23	DISEASES inferred ¹⁴
21	PRL	Prolactin	Protein Coding	5.23	DISEASES inferred ¹⁴
22	IL2	Interleukin 2	Protein Coding	5.22	DISEASES inferred ¹⁴
23	GJB6	Gap Junction Protein Beta 6	Protein Coding	5.18	DISEASES inferred ¹⁴
24	TEX14	Testis Expressed 14, Intercellular Bridge Forming Factor	Protein Coding	5.18	DISEASES inferred ¹⁴
25	FOXP3	Forkhead Box P3	Protein Coding	5.15	DISEASES inferred ¹⁴
26	IL17A	Interleukin 17A	Protein Coding	5.15	DISEASES inferred ¹⁴

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Variations for Orchitis

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Expression for Orchitis

Search GEO for disease gene expression data for Orchitis.

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Pathways for Orchitis

Pathways related to Orchitis according to GeneCards Suite gene sharing:

(show all 49)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.94	CCL2 CCR6 CD4 CD68 CD8A CRP
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.39	TNF IL6 IL1B IL10 CD4 CCR6
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.31	TNF IL6 IL1B IL10 IFNA2 CD4
4	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.29	TNF IL6 IL1B IL10 CD4 CCR6
5	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.57	CCL2 CD4 IL10 IL1B IL6 TNF
6	NF-kappaB Signaling ³	12.55	TNF IL1B IL10 CD8A CCL2
7	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.5	TNF IL6 IL1B IFNA2
8	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.16	TNF IL6 IL1B IL10
9	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.13	TNF IL10 CD8A CD4
10	Neuroinflammation and glutamatergic signaling ⁷⁴	12.09	IL10 IL1B IL6 TNF
11	Spinal cord injury ⁷⁴	11.99	TNF IL6 IL1B CCL2
12	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.97	TNF IL6 IL1B IL10 CCL2
13	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.91	TNF IL6 IL1B IL10 CD4
14	CCL18 signaling pathway ⁷⁴	11.9	IL6 IL10 CCR6 CCL2
15	Acute viral myocarditis ⁷⁴	11.75	IL6 IL10 CD4
16	Burn wound healing ⁷⁴	11.75	TNF IL6 IL1B IFNA2 CCL2
17	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.74	TNF IL6 IL10 CRP
18	AP-1 transcription factor network ⁶¹	11.71	CCL2 IL10 IL6
19	Th17 cell differentiation pathway ⁷⁴	11.71	CD4 IL1B IL6
20	Innate Lymphoid Cells Differentiation ⁶⁵	11.7	CCR6 CD4 CD8A IL10 IL1B TNF
21	Lung fibrosis ⁷⁴	11.68	TNF IL6 IL1B CCL2
22	IL 10 signaling pathway ⁶⁷	11.67	TNF IL6 IL1B IL10
23	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.66	TNF IL6 IL1B
24	miRNAs involvement in the immune response in sepsis ⁷⁴	11.65	TNF IL6 IL10
25	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.63	TNF IL6 IL10
26	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.57	TNF IL10 CCL2 ACE2
27	Netrin-UNC5B signaling pathway ⁷⁴	11.56	CCL2 IL10 TNF
28	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.56	TNF IL6 IFNA2 CCL2
29	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.56	TNF IL6 IL10 IFNA2 CD8A CD68
30	MSP-RON Signaling ⁶⁴	11.52	TNF IL1B CCL2
31	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.52	IL6 CRP CD8A CD4 CCL2 ACE2
32	Nonalcoholic fatty liver disease ⁷⁴	11.5	TNF IL6 CCL2
33	Interleukin-10 signaling ⁶⁶	11.5	TNF IL6 IL1B IL10 CCL2
34	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.49	TNF IL6 IL1B
35	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.46	TNF IL6 CCL2
36	IL-10 Pathway ⁶⁴	11.37	TNF IL6 IL1B IL10
37	Development and heterogeneity of the ILC family ⁷⁴	11.31	TNF IL6 IL1B
38	Prostaglandin signaling ⁷⁴	11.24	CCL2 IL1B IL6 TNF
39	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.24	TNF IL6 IL1B CCL2 ACE2
40	Immune infiltration in pancreatic cancer ⁷⁴	11.23	TNF IL6 IL10
41	Cytokines and inflammatory response ⁷⁴	11.12	TNF IL6 IL1B IL10 CD4
42	LDL- influence on CD14 and TLR4 ⁷⁴	11.1	IL6 IL1B IL10
43	Overview of nanoparticle effects ⁷⁴	11.05	TNF IL6 CRP
44	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.04	TNF IL6 IL1B IL10 IFNA2 CD8A
45	G-protein signaling_Rap2B regulation pathway ²²	11.01	TNF IL6 IL1B IL10 CCL2
46	LDL Oxidation in Atherogenesis ⁶⁴	10.96	TNF IL1B CD68 CCL2
47	COVID-19 adverse outcome pathway ⁷⁴	10.71	TMPRSS2 IL6 CCL2 ACE2
48	SARS-CoV-2 and COVID-19 pathway ⁷⁴	10.7	TMPRSS2 ACE2
49	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.37	TNF IL6

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GO Terms for Orchitis

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	10.3	TNF IL6 IL1B IFNA2 CRP CCL2
2	defense response to Gram-positive bacterium	GO:0050830	10.17	TNF IL6 IL1B CRP
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.16	TNF IL6 IL1B IL10
4	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.05	TNF IL1B CCL2
5	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.02	IL10 IL6 TNF
6	liver regeneration	GO:0097421	9.99	TNF IL6 IL10
7	negative regulation of neurogenesis	GO:0050768	9.95	IL1B IL6 TNF
8	positive regulation of glial cell proliferation	GO:0060252	9.91	TNF IL6 IL1B
9	cellular response to lipopolysaccharide	GO:0071222	9.9	TNF IL6 IL1B IL10 CD68 CCL2
10	negative regulation of cytokine production involved in immune response	GO:0002719	9.89	TNF IL10
11	positive regulation of fever generation	GO:0031622	9.88	TNF IL1B
12	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.88	TNF IL1B IL10
13	positive regulation of neuroinflammatory response	GO:0150078	9.85	TNF IL6 IL1B
14	sequestering of triglyceride	GO:0030730	9.84	TNF IL1B
15	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.8	TNF IL1B
16	negative regulation of lipid storage	GO:0010888	9.8	TNF IL6 CRP
17	chronic inflammatory response to antigenic stimulus	GO:0002439	9.76	TNF IL10
18	vascular endothelial growth factor production	GO:0010573	9.73	IL1B IL6 TNF
19	immune response	GO:0006955	9.73	TNF IL6 IL1B IL10 CD8A CD4
20	humoral immune response	GO:0006959	9.32	TNF IL6 IFNA2 CCR6 CCL2

Molecular functions related to Orchitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.36	TNF IL6 IL1B IL10 IFNA2 CCL2

Sources

Sources for Orchitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ORC001 MIFTS: 44	Orchitis Categories: Endocrine diseases, Infectious diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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