MCID: ORC001
MIFTS: 44

Orchitis

Categories: Endocrine diseases, Infectious diseases, Reproductive diseases
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Aliases & Classifications for Orchitis

MalaCards integrated aliases for Orchitis:

Name: Orchitis 11 43 14 16 71 75
Inflammation of Testis 11
Mumps Orchitis 33
Orchititis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2518
MeSH 43 D009920
NCIt 49 C97145
SNOMED-CT 68 367112009
ICD11 33 333831364
UMLS 71 C0029191

Summaries for Orchitis

MalaCards based summary: Orchitis, also known as inflammation of testis, is related to granulomatous orchitis and epididymo-orchitis. An important gene associated with Orchitis is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and t cells, and related phenotype is immune system.

Wikipedia: 75 Orchitis is inflammation of the testes. It can also involve swelling, pains and frequent infection,... more...

Related Diseases for Orchitis

Diseases related to Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1041)
# Related Disease Score Top Affiliating Genes
1 granulomatous orchitis 32.6 ZAN CD68
2 epididymo-orchitis 32.4 ZAN TEX11 IL6 CRP
3 mumps 31.4 TNF IL6 IL1B IL10
4 parotitis 31.1 CRP CD8A CD4
5 brucellosis 31.0 TNF IL6 IL10 CRP
6 testicular torsion 30.9 TNF IL1B EPPIN CRP
7 urogenital tuberculosis 30.7 CRP CD4
8 prostatitis 30.6 TNF IL6 IL1B IL10
9 syphilis 30.5 TNF CRP CD8A CD4 CCR6
10 polyarteritis nodosa 30.5 TNF IL6 IFNA2 CRP
11 azoospermia 30.4 TEX11 IL1B EPPIN CFAP47 ACE2
12 histoplasmosis 30.3 TNF CD4 CCR6
13 urinary tract infection 30.3 TNF IL6 IL1B IL10 H2AC18 CRP
14 chlamydia 30.3 TNF IL6 IL1B IL10 CRP CCL2
15 rubella 30.3 TNF IL6 IL1B IL10
16 relapsing polychondritis 30.2 TNF IL6 CRP CD4
17 nocardiosis 30.2 TNF CRP CD4
18 filariasis 30.2 TNF IL6 IL10 CD4
19 encephalitis 30.2 TNF IL6 IL1B IL10 CCL2
20 filarial elephantiasis 30.2 TNF IL10 CD8A CD4
21 spermatogenic failure, x-linked, 1 30.2 TEX11 EPPIN CFAP47
22 testicular disease 30.2 TNF IL6 H2AC18 EPPIN CD8A CD4
23 haemophilus influenzae 30.2 TNF IL1B
24 henoch-schoenlein purpura 30.2 TNF IL6 CRP CD4 CCR6
25 autoimmune disease 30.2 TNF IL6 IL1B IL10 CRP CCR6
26 typhoid fever 30.2 TNF IL6 IL1B CRP CCR6
27 epidemic typhus 30.1 IL10 CRP CD8A CD4
28 purpura 30.1 TNF IL6 IL1B IL10 CRP
29 meningitis 30.1 TNF IL6 IL1B IL10 CRP CCL2
30 paratyphoid fever 30.1 TNF IL1B CRP
31 scrub typhus 30.1 TNF IL1B IL10 CRP
32 pancreatitis 30.1 TNF IL6 IL1B IL10 CRP
33 bacteriuria 30.1 IL6 CRP CCL2
34 diverticulitis 30.1 TNF IL6 CRP CCR6
35 toxoplasmosis 30.0 TNF IL6 IL1B IL10
36 igg4-related disease 30.0 IL10 CRP CD4 CCR6
37 vasculitis 30.0 TNF IL6 IL1B IL10 IFNA2 CRP
38 tertiary syphilis 30.0 TNF IL10 CRP CD8A CD4
39 gout 30.0 TNF IL6 IL1B CRP
40 sialadenitis 30.0 TNF CD4 CCR6
41 thyroiditis 30.0 TNF IL6 IL1B IL10 CRP
42 gastroenteritis 29.9 TNF IL6 IL1B IL10 IFNA2 CRP
43 infective endocarditis 29.9 IL6 CRP CCR6
44 salmonellosis 29.9 TNF IL6 IL1B IL10 CD8A CD4
45 sleeping sickness 29.9 TNF IL10 H2AC18
46 melioidosis 29.9 TNF IL6 IL10
47 endometritis 29.9 TNF IL6 IL1B
48 interstitial nephritis 29.9 TNF CRP CD8A CD4 CCR6
49 thrombocytopenic purpura, autoimmune 29.9 IFNA2 CD8A CD4 CCR6
50 urethritis 29.9 TNF IL6 IL1B IL10 CRP CD8A

Graphical network of the top 20 diseases related to Orchitis:



Diseases related to Orchitis

Symptoms & Phenotypes for Orchitis

GenomeRNAi Phenotypes related to Orchitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACE2 CCL2 CCR6 CD4 CD68 CD8A
2 no effect GR00402-S-2 10.18 CCL2 CCR6 CD4 CD68 CFAP47 CLDN11

MGI Mouse Phenotypes related to Orchitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.47 ACE2 CCL2 CCR6 CD4 CD68 CD8A

Drugs & Therapeutics for Orchitis

Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis - a Randomized Controlled Trial Unknown status NCT02665182
2 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Unknown status NCT03969979
3 Analgetics vs Analgetics and Antibiotics for Pediatric Clinical and Sonographic Orchitis or Epididymitis Completed NCT04489979
4 Prospective Observational Study on SEBBIN Silicone Gel-filled Testicular Implants Recruiting NCT05097820

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

Genetic Tests for Orchitis

Anatomical Context for Orchitis

Organs/tissues related to Orchitis:

MalaCards : Testis, Testes, T Cells, Bone Marrow, Prostate, Lymph Node, Spinal Cord

Publications for Orchitis

Articles related to Orchitis:

(show top 50) (show all 2427)
# Title Authors PMID Year
1
Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis. 53 62
10840112 2000
2
Successful interferon-alpha 2 a therapy for a patient with acute mumps orchitis. 53 62
7744163 1995
3
Systemic treatment with interferon-alpha 2B: an effective method to prevent sterility after bilateral mumps orchitis. 53 62
2056606 1991
4
[Systemic alpha-interferon therapy: a possible method for prevention of testicular atrophy and permanent sterility in patients with bilateral mumps orchitis]. 53 62
1926670 1991
5
Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion. 62
35593125 2022
6
Urological Impact of Epididymo-orchitis in Patients with Anorectal Malformation: An ARM-Net Consortium Study. 62
35073590 2022
7
Local adrenomedullin gene delivery inhibits Leydig cell dysfunction by rescuing steroidogenic enzymes in vivo. 62
35942817 2022
8
Pediatric Non-Testicular Torsion Acute Scrotum-Is the Use of Prophylactic Antibiotics in Patients With Normal Urine Analysis Justified? 62
35878814 2022
9
Torsion of the spermatic cord in adults: a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion. 62
35322657 2022
10
Tuberculosis Epididymo-Orchitis Mimicking Malignancy Resulting from Intravesical Bacillus Calmette-Guérin Immunotherapy for Bladder Cancer: A Case Report of a Rare Complication. 62
36359505 2022
11
Epididymo-orchitis secondary to colovesical fistula. 62
36438455 2022
12
Clinical spectrum and management options for prostatic utricle in children. 62
35101262 2022
13
Antineutrophil cytoplasmic antibody associated vasculitis: a converging diagnosis from neuropathy and testicular infarcts. 62
36452284 2022
14
EPIDIDYMO-ORCHITIS LEADING TO GLOBAL TESTICULAR INFARCTION IN A PEDIATRIC PATIENT - A CASE REPORT. 62
36450319 2022
15
Diffuse granulomatous orchitis involved the whole testis: Diagnostic clue in magnetic resonance imaging. 62
36435623 2022
16
Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan. 62
36372306 2022
17
Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis. 62
36434305 2022
18
Sonographic findings of COVID-19 related acute scrotal infection and associations with clinical-laboratory data. 62
35775362 2022
19
Incidental Tuberculosis Epididymitis/Epididymo-orchitis: A Retrospective Analysis at a Tertiary Center in Taiwan. 62
35798186 2022
20
Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis. 62
35912293 2022
21
Investigation of the outbreaks of abortions and orchitis in livestock in Namibia during 2016-2018. 62
36242679 2022
22
Severe Generalized Epidemic Myalgia in an Adult due to Human Parechovirus Type 3: A Case Report. 62
36420236 2022
23
Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. 62
35748405 2022
24
Is testicular microlithiasis associated with testicular pathologies in children? 62
35829746 2022
25
Testicular Plasmacytoma Masking as Epididymo-orchitis in a Known Multiple Myeloma Patient. 62
36060019 2022
26
The Pseudo-Bladder: A Case of the Prostatic Urethra Masquerading as the Bladder. 62
36179861 2022
27
Epididymo-Orchitis and Pelvic Abscess in a Patient With Inflatable Penile Prosthesis. 62
36320940 2022
28
Impact of vaccine effectiveness and coverage on preventing large mumps outbreaks on college campuses: Implications for vaccination strategy. 62
35728505 2022
29
Epididymo-orchitis caused by Histoplasma capsulatum. 62
35651534 2022
30
Antimicrobial peptide MPX attenuates LPS-induced inflammatory response and blood-testis barrier dysfunction in Sertoli cells. 62
35842953 2022
31
Male Reproductive Tract Involvement and Sperm Parameters in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis. 62
36102101 2022
32
Presentations of the Acute Scrotum During the COVID-19 Pandemic: Experiences of a Non-urological Centre. 62
36127974 2022
33
A simplified ultrasound approach to diagnose testicular torsion and predict unsalvageable testis. 62
35437523 2022
34
Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level. 62
35962439 2022
35
Testicular Germ Cell Tumours-The Role of Conventional Ultrasound. 62
36010875 2022
36
Immune homeostasis and disorder in the testis - Roles of Sertoli cells. 62
35580404 2022
37
The role of a urine dipstick in the diagnosis of the acute scrotum. 62
35783592 2022
38
[Orchiectomy due to early syphilis]. 62
35166861 2022
39
Minor lobulation of the testis, mimicking polyorchidism when inflammed, discussion of a rare case: A case report. 62
35907296 2022
40
Vasitis mimicking an inguinal hernia: A diagnostic dilemma. 62
35520032 2022
41
Newer Insights into Prostatic Utricle in Proximal Hypospadias. 62
36238343 2022
42
External Male Genitalia in Henoch-Schönlein Syndrome: A Systematic Review. 62
36010045 2022
43
Sodium-glucose cotransporter 2 inhibitor-associated severe epididymo-orchitis. 62
35817490 2022
44
Xanthogranulomatous orchitis: A rare case of testicular mass. 62
35586401 2022
45
COVID-19 and Genitourinary Tract: A Retrospective Study in the Tertiary Care Center. 62
36017292 2022
46
Immune cell characterization in spontaneous autoimmune orchitis in dogs. 62
35633611 2022
47
Testicular exosomes disturb the immunosuppressive phenotype of testicular macrophages mediated by miR-155-5p in uropathogenic Escherichia coli-induced orchitis. 62
35915541 2022
48
Genetic diversity of Chlamydia pecorum detected in sheep flocks from Mexico. 62
35119684 2022
49
A short review of male genito-urinary lesions caused by coronavirus disease 2019. 62
36246426 2022
50
Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.). 62
35227784 2022

Variations for Orchitis

Expression for Orchitis

Search GEO for disease gene expression data for Orchitis.

Pathways for Orchitis

Pathways related to Orchitis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 CCL2 CCR6 CD4 CD68 CD8A CRP
2
Show member pathways
13.39 TNF IL6 IL1B IL10 CD4 CCR6
3
Show member pathways
13.31 TNF IL6 IL1B IL10 IFNA2 CD4
4
Show member pathways
13.29 TNF IL6 IL1B IL10 CD4 CCR6
5
Show member pathways
12.57 CCL2 CD4 IL10 IL1B IL6 TNF
6 12.55 TNF IL1B IL10 CD8A CCL2
7
Show member pathways
12.5 TNF IL6 IL1B IFNA2
8 12.16 TNF IL6 IL1B IL10
9
Show member pathways
12.13 TNF IL10 CD8A CD4
10 12.09 IL10 IL1B IL6 TNF
11 11.99 TNF IL6 IL1B CCL2
12 11.97 TNF IL6 IL1B IL10 CCL2
13
Show member pathways
11.91 TNF IL6 IL1B IL10 CD4
14 11.9 IL6 IL10 CCR6 CCL2
15 11.75 IL6 IL10 CD4
16 11.75 TNF IL6 IL1B IFNA2 CCL2
17 11.74 TNF IL6 IL10 CRP
18 11.71 CCL2 IL10 IL6
19 11.71 CD4 IL1B IL6
20 11.7 CCR6 CD4 CD8A IL10 IL1B TNF
21 11.68 TNF IL6 IL1B CCL2
22 11.67 TNF IL6 IL1B IL10
23
Show member pathways
11.66 TNF IL6 IL1B
24 11.65 TNF IL6 IL10
25
Show member pathways
11.63 TNF IL6 IL10
26 11.57 TNF IL10 CCL2 ACE2
27 11.56 CCL2 IL10 TNF
28 11.56 TNF IL6 IFNA2 CCL2
29 11.56 TNF IL6 IL10 IFNA2 CD8A CD68
30 11.52 TNF IL1B CCL2
31
Show member pathways
11.52 IL6 CRP CD8A CD4 CCL2 ACE2
32 11.5 TNF IL6 CCL2
33 11.5 TNF IL6 IL1B IL10 CCL2
34 11.49 TNF IL6 IL1B
35 11.46 TNF IL6 CCL2
36 11.37 TNF IL6 IL1B IL10
37 11.31 TNF IL6 IL1B
38 11.24 CCL2 IL1B IL6 TNF
39 11.24 TNF IL6 IL1B CCL2 ACE2
40 11.23 TNF IL6 IL10
41 11.12 TNF IL6 IL1B IL10 CD4
42 11.1 IL6 IL1B IL10
43 11.05 TNF IL6 CRP
44 11.04 TNF IL6 IL1B IL10 IFNA2 CD8A
45 11.01 TNF IL6 IL1B IL10 CCL2
46 10.96 TNF IL1B CD68 CCL2
47 10.71 TMPRSS2 IL6 CCL2 ACE2
48 10.7 TMPRSS2 ACE2
49
Show member pathways
10.37 TNF IL6

GO Terms for Orchitis

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.3 TNF IL6 IL1B IFNA2 CRP CCL2
2 defense response to Gram-positive bacterium GO:0050830 10.17 TNF IL6 IL1B CRP
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.16 TNF IL6 IL1B IL10
4 lipopolysaccharide-mediated signaling pathway GO:0031663 10.05 TNF IL1B CCL2
5 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.02 IL10 IL6 TNF
6 liver regeneration GO:0097421 9.99 TNF IL6 IL10
7 negative regulation of neurogenesis GO:0050768 9.95 IL1B IL6 TNF
8 positive regulation of glial cell proliferation GO:0060252 9.91 TNF IL6 IL1B
9 cellular response to lipopolysaccharide GO:0071222 9.9 TNF IL6 IL1B IL10 CD68 CCL2
10 negative regulation of cytokine production involved in immune response GO:0002719 9.89 TNF IL10
11 positive regulation of fever generation GO:0031622 9.88 TNF IL1B
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.88 TNF IL1B IL10
13 positive regulation of neuroinflammatory response GO:0150078 9.85 TNF IL6 IL1B
14 sequestering of triglyceride GO:0030730 9.84 TNF IL1B
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.8 TNF IL1B
16 negative regulation of lipid storage GO:0010888 9.8 TNF IL6 CRP
17 chronic inflammatory response to antigenic stimulus GO:0002439 9.76 TNF IL10
18 vascular endothelial growth factor production GO:0010573 9.73 IL1B IL6 TNF
19 immune response GO:0006955 9.73 TNF IL6 IL1B IL10 CD8A CD4
20 humoral immune response GO:0006959 9.32 TNF IL6 IFNA2 CCR6 CCL2

Molecular functions related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TNF IL6 IL1B IL10 IFNA2 CCL2

Sources for Orchitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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