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MCID: ORC001
MIFTS: 43

Orchitis

Categories: Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Orchitis

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MalaCards integrated aliases for Orchitis:

Name: Orchitis 12 44 15 17 70
Inflammation of Testis 12
Orchititis 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2518
MeSH 44 D009920
NCIt 50 C97145
SNOMED-CT 67 367112009
ICD10 32 N45.2
UMLS 70 C0029191
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Summaries for Orchitis

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MalaCards based summary : Orchitis, also known as inflammation of testis, is related to granulomatous orchitis and parotitis. An important gene associated with Orchitis is EPPIN (Epididymal Peptidase Inhibitor), and among its related pathways/superpathways are Allograft rejection and Immune response IL-23 signaling pathway. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and bone, and related phenotypes are immune system and endocrine/exocrine gland

Wikipedia : 73 Orchitis is inflammation of the testes. It can also involve swelling, pains and frequent infection,... more...

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Related Diseases for Orchitis

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Diseases related to Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 865)
# Related Disease Score Top Affiliating Genes
1 granulomatous orchitis 32.4 ZAN CD68
2 parotitis 31.0 CRP CD8A CD4
3 mumps 30.8 TNF IL6 IL2 IL1B IL10
4 brucellosis 30.7 TNF IL6 IL2 IL10 CRP
5 tuberculous epididymitis 30.5 TNF CRP
6 pertussis 30.3 TNF IL6 IL1B IL10
7 purpura 30.2 TNF IL6 IL10 CRP
8 pfeiffer syndrome 30.2 IL2 H2AC18 CD8A CD4
9 histoplasmosis 30.2 TNF CD8A CD4
10 bacteriuria 30.2 IL6 H2AC18 CRP
11 nocardiosis 30.2 TNF CRP CD4
12 chlamydia 30.2 TNF IL6 IL1B IL10 CRP
13 syphilis 30.1 TNF IL6 FOXP3 CRP CD8A CD4
14 mycobacterium tuberculosis 1 30.1 TNF IL10 H2AC18 CD8A CD4
15 encephalitis 30.1 TNF IL6 IL1B IL10
16 extrapulmonary tuberculosis 30.0 IL1B IL10 CRP
17 posterior urethral valves 30.0 TNF IL6 ACE2
18 systemic autoimmune disease 30.0 IL6 CRP
19 relapsing polychondritis 30.0 IL6 IL2 IL10 CRP
20 secondary syphilis 30.0 CRP CD8A CD4
21 typhoid fever 30.0 TNF IL6 IL1B CRP
22 genital herpes 30.0 IL10 CD8A CD4
23 fasciitis 29.9 TNF IL6 IL2
24 sleeping sickness 29.9 IL6 IL10 H2AC18
25 tertiary syphilis 29.9 TNF IL10 CRP CD8A CD4
26 diverticulitis 29.9 TNF IL6 CRP
27 epidemic typhus 29.9 TNF IL10 CRP CD8A CD4
28 t cell deficiency 29.9 IL2 CD8A CD4
29 melioidosis 29.9 TNF IL6 IL10
30 infective endocarditis 29.9 TNF IL6 CRP
31 schistosomiasis 29.8 TNF IL2 IL10
32 measles 29.8 TNF IL6 IL2 IL1B
33 cryptococcosis 29.8 TNF IL10 CD8A CD4
34 filariasis 29.8 TNF IL6 IL2 IL10 CRP
35 lepromatous leprosy 29.8 TNF IL2 IL10
36 acute cystitis 29.8 TNF IL6 IL1B IL10 H2AC18 CRP
37 scrub typhus 29.7 TNF IL1B IL10 CRP
38 prostatitis 29.7 TNF IL6 IL2 IL1B IL10 FOXP3
39 endocarditis 29.7 TNF IL6 IL10 CRP
40 cystitis 29.7 TNF IL6 IL2 CRP
41 pancreatitis 29.7 TNF IL6 IL1B CRP
42 gastroenteritis 29.7 TNF IL6 IL1B IL10 CRP
43 salmonellosis 29.7 TNF IL6 IL1B IL10 CD8A CD4
44 meningitis 29.6 TNF IL6 IL2 IL1B IL10 CRP
45 pulmonary tuberculosis 29.6 TNF IL6 IL2 IL10
46 hantavirus hemorrhagic fever with renal syndrome 29.6 TNF IL6 CRP CD8A CD4
47 rubella 29.6 TNF IL6 IL2 IL1B IL10
48 aseptic meningitis 29.6 TNF IL1B IL10 CRP
49 acute myocarditis 29.6 TNF IL10 H2AC18 CRP CD4
50 urticaria 29.5 TNF IL6 IL10 CRP CD4

Graphical network of the top 20 diseases related to Orchitis:



Diseases related to Orchitis
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Symptoms & Phenotypes for Orchitis

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MGI Mouse Phenotypes related to Orchitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.07 ACE2 CD4 CD68 CD8A CRP FOXP3
2 endocrine/exocrine gland MP:0005379 10.06 CD4 CD8A CLDN11 CRISP1 FOXP3 GJB6
3 integument MP:0010771 9.81 ACE2 CD4 CD8A FOXP3 GJB6 IL10
4 no phenotypic analysis MP:0003012 9.56 CD4 CD68 CRISP1 FOXP3 GJB6 IL10
5 reproductive system MP:0005389 9.32 CLDN11 CRISP1 CRISP2 FOXP3 IL10 IL2
Sources

Drugs & Therapeutics for Orchitis

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Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents
2 Antibiotics, Antitubercular
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis - a Randomized Controlled Trial Unknown status NCT02665182
2 Analgetics vs Analgetics and Antibiotics for Pediatric Clinical and Sonographic Orchitis or Epididymitis Recruiting NCT04489979
3 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Recruiting NCT03969979

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

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Genetic Tests for Orchitis

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Anatomical Context for Orchitis

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MalaCards organs/tissues related to Orchitis:

40
Testis, Testes, Bone, Skin, Heart, Lung, Prostate
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Publications for Orchitis

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Articles related to Orchitis:

(show top 50) (show all 2262)
# Title Authors PMID Year
1
Tuberculous epididymo-orchitis secondary to Bacillus Calmette-Guérin (BCG) in non-muscular invasive bladder cancer. 61
33796443 2021
2
A challenging case of surgical management of a single ischemic testicle from severe epididymo-orchitis. 61
33680852 2021
3
A severe complication of intravesical bacillus Calmette-Guerin: An effect of different strains. 61
33598408 2021
4
Radiological patterns of incidental epididymitis in mild-to-moderate COVID-19 patients revealed by colour Doppler ultrasound. 61
33565141 2021
5
Melatonin alleviates LPS-induced endoplasmic reticulum stress and inflammation in spermatogonial stem cells. 61
32996162 2021
6
SARS-CoV-2 infection affects the lower urinary tract and male genital system: A systematic review. 61
33595134 2021
7
A coronavirus disease 2019 (COVID-19) patient with bilateral orchitis. 61
32888763 2021
8
Amyand's hernia: presumptive diagnosis by CT and literature review. 61
33613803 2021
9
Assessment of the Pathogenicity of Rickettsia amblyommatis, Rickettsia bellii, and Rickettsia montanensis in a Guinea Pig Model. 61
33600263 2021
10
Effects of COVID-19 on male sex function and its potential sexual transmission. 61
33754609 2021
11
Testicular torsion in the medicolegal perspective: Why is the diagnosis missing? 61
33630295 2021
12
Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage. 61
33482358 2021
13
COVID-19 and male fertility: Taking stock of one year after the outbreak began. 61
33754623 2021
14
Cystoscopic Management of Prostatic Utricles. 61
32949553 2021
15
An unusual location of hand, foot and mouth disease. 61
33743167 2021
16
Characterization of epididymal and testicular histologic lesions and use of immunohistochemistry and PCR on formalin-fixed tissues to detect Brucella canis in male dogs. 61
33468036 2021
17
Complicated diverticular disease presenting as recurrent epididymo-orchitis: a case report. 61
33734549 2021
18
Review of COVID-19 and male genital tract. 61
33236375 2021
19
The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma. 61
33557577 2021
20
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 61
33530122 2021
21
Relevance of angiogenesis in autoimmune testis inflammation. 61
33313783 2021
22
Immune checkpoint inhibitor-related hypogonadism and infertility: a neglected issue in immuno-oncology. 61
33589529 2021
23
COVID-19 May Affect Male Fertility but is Not Sexually Transmitted: A Systematic Review. 61
33558864 2021
24
Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells. 61
33639974 2021
25
Case Report: A Rare Case of Crimean-Congo Hemorrhagic Fever Associated with Epididymo-Orchitis. 61
33399048 2021
26
Sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection. 61
32341210 2021
27
Beyond germ cell tumors, unusual testicular and extra-testicular masses and mass-like lesions: MRI and US pictorial review. 61
33485115 2021
28
Biopsy-confirmed Genitourinary Tuberculosis in a Secondary Health Care Hospital: An Evidence-based Clinical Review. 61
33763390 2021
29
Isolated tuberculosis of testis: A case report. 61
33680408 2021
30
Brucellosis Presenting with Febrile Pancytopenia: An Atypical Presentation of a Common Disease and Review of Brucellosis. 61
33489391 2021
31
Relationship between COVID-19 and the male reproductive system. 61
33577068 2021
32
Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance. 61
32733025 2021
33
Uropathogenic Escherichia coli Infection Compromises the Blood-Testis Barrier by Disturbing mTORC1-mTORC2 Balance. 61
33679734 2021
34
Does SARS-CoV-2 Threaten Male Fertility? 61
33656720 2021
35
No detection of SARS-CoV-2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID-19 male patients: A perspective and urogenital evaluation. 61
33150723 2021
36
Bisphenol A exposure increases epididymal susceptibility to infection in mice. 61
33091778 2021
37
Identification and description of mumps cases in a non-outbreak setting and evaluation of the effectiveness of mumps-containing vaccines over time. 61
32401599 2020
38
Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis. 61
33327643 2020
39
Testicular Torsion in a Rare Case of Prostatic Spindle Cell Rhabdomyosarcoma. 61
33505810 2020
40
A case of acute vasitis mimicking an incarcerated inguinal hernia with subtle imaging findings. 61
33325356 2020
41
T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes. 61
33374605 2020
42
Monolateral chronicon orchitis in a stallion. 61
32602673 2020
43
Successful activation of rat T lymphocytes by sperm specific antigens in vitro. 61
33012735 2020
44
Small testes: clinical characteristics and ultrasonographic findings. 61
33455146 2020
45
Testicular tuberculosis: An uncommon complication after treatment of urothelial carcinoma. 61
32983302 2020
46
Acute vasitis presenting as a concerning paratesticular mass in an adolescent, a case report. 61
33102059 2020
47
Candida urinary tract infections in adults. 61
31654220 2020
48
Testicular pain as an unusual presentation of COVID-19: a brief review of SARS-CoV-2 and the testis. 61
32826162 2020
49
Synthetic Food dyes cause testicular damage via up-regulation of pro-inflammatory cytokines and down-regulation of FSH-R and TESK-1 gene expression. 61
33565293 2020
50
Resolution of bilateral testicular masses after viral infection. 61
33102086 2020
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Variations for Orchitis

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Expression for Orchitis

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Search GEO for disease gene expression data for Orchitis.
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Pathways for Orchitis

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Pathways related to Orchitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 36 1
Show member pathways
 12.75 TNF IL6 IL2 IL1B IL10 FOXP3
2
Immune response IL-23 signaling pathway 23
Show member pathways
 12.59 TNF IL6 IL2 IL1B IL10 CD4
3
NF-kappaB Signaling 4
12.56 TNF IL2 IL1B IL10 FOXP3 CD8A
4
T cell receptor signaling pathway 36
Show member pathways
 12.54 TNF IL6 IL2 IL1B IL10 CD8A
5
Th17 cell differentiation 36
Show member pathways
 12.51 TNF IL6 IL2 IL1B IL10 FOXP3
6
Selenium Micronutrient Network 1
Show member pathways
 12.36 TNF IL6 IL2 IL1B CRP
7
Human T-cell leukemia virus 1 infection 36
12.33 TNF IL6 IL2 CD4
8
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.32 TNF IL6 IL2 IL10
9
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.26 TNF IL6 IL2 IL1B IL10
10
Tuberculosis 36
12.23 TNF IL6 IL1B IL10
11
C-type lectin receptor signaling pathway 36
Show member pathways
 12.23 TNF IL6 IL2 IL1B IL10
12
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.17 TNF IL6 IL1B IL10
13
Spinal Cord Injury 1
12.03 TNF IL6 IL2 IL1B
14
Interleukin-4 and 13 signaling 65
12 TNF IL6 IL1B IL10
15
IL12-mediated signaling events 1
Show member pathways
 11.99 IL2 IL1B CD8A CD4
16
Amoebiasis 36
11.94 TNF IL6 IL1B IL10
17
Yersinia infection 36
11.94 TNF IL6 IL2 IL1B IL10 CD8A
18
Hematopoietic cell lineage 36
11.87 TNF IL6 IL1B CD8A CD4
19
Pertussis 36
11.79 TNF IL6 IL1B IL10
20
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.76 TNF IL6 IL2 IL10 CD8A CD68
21
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.75 TNF IL2 FOXP3
22
Innate Lymphoid Cell Differentiation Pathways 64
11.75 TNF IL2 IL1B IL10 CD8A CD4
23
IgA-Producing B Cells in the Intestine 64
11.72 TNF IL6 IL10 FOXP3
24
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 TNF IL6 IL2 IL1B
25
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TNF IL6 IL2 IL1B IL10 CD4
26
Lung fibrosis 1
11.66 TNF IL6 IL1B
27
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.64 TNF IL2 CD8A
28
Legionellosis 36
11.61 TNF IL6 IL1B
29
Malaria 36
11.56 TNF IL6 IL1B IL10
30
Photodynamic therapy-induced AP-1 survival signaling. 1
11.55 TNF IL6 IL2
31
Interleukin-10 signaling 65
11.54 TNF IL6 IL1B IL10
32
Aryl Hydrocarbon Receptor Pathway 1
11.52 TNF IL2 IL1B
33
Th2 Differentiation Pathway 64
11.5 IL2 IL10 FOXP3 CD4
34
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.49 TNF IL6 IL1B
35
African trypanosomiasis 36
11.39 TNF IL6 IL1B IL10
36
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.37 TNF IL2 IL10 FOXP3
37
Dendritic Cells Developmental Lineage Pathway 64
11.37 TNF IL6 IL2 IL1B IL10 CD8A
38
IL-10 Pathway 63
11.34 TNF IL6 IL1B IL10
39
Development and heterogeneity of the ILC family 1
11.33 TNF IL6 IL1B
40
Antifolate resistance 36
11.31 TNF IL6 IL1B
41
Overview of nanoparticle effects 1
11.07 TNF IL6 CRP
42
LDL Oxidation in Atherogenesis 63
10.99 TNF IL1B CD68
43
Cytokines and Inflammatory Response 1
10.56 TNF IL6 IL2 IL1B IL10 CD4
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GO Terms for Orchitis

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Cellular components related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ZAN TNF IL6 IL2 IL1B IL10
2 extracellular region GO:0005576 9.44 VWA7 TNF RNASE10 IL6 IL2 IL1B

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.09 TNF IL6 IL1B IL10 FOXP3 CD4
2 positive regulation of gene expression GO:0010628 10.07 TNF IL6 IL1B FOXP3 CRP
3 negative regulation of cell proliferation GO:0008285 10.04 IL6 IL1B IL10 GJB6 FOXP3
4 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL2 IL1B CD4
5 response to lipopolysaccharide GO:0032496 9.89 IL1B IL10 GJB6 FOXP3
6 regulation of insulin secretion GO:0050796 9.84 TNF IL6 IL1B
7 negative regulation of interleukin-6 production GO:0032715 9.83 TNF IL10 FOXP3
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNF IL6 IL2
9 response to glucocorticoid GO:0051384 9.81 TNF IL6 IL10
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 TNF IL6 IL1B IL10
11 positive regulation of interferon-gamma production GO:0032729 9.8 TNF IL2 IL1B
12 positive regulation of interleukin-8 production GO:0032757 9.79 TNF IL6 IL1B
13 cellular response to lipopolysaccharide GO:0071222 9.77 TNF IL6 IL1B IL10 CD68
14 T cell activation GO:0042110 9.75 FOXP3 CD8A CD4
15 cytokine-mediated signaling pathway GO:0019221 9.73 TNF IL6 IL2 IL1B IL10 CD4
16 positive regulation of T cell proliferation GO:0042102 9.71 IL6 IL2 IL1B CD4
17 positive regulation of JAK-STAT cascade GO:0046427 9.7 TNF IL6 IL10
18 immune response GO:0006955 9.7 TNF IL6 IL2 IL1B IL10 CD8A
19 T cell mediated immunity GO:0002456 9.67 FOXP3 CD8A
20 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
21 negative regulation of neurogenesis GO:0050768 9.67 TNF IL6 IL1B
22 negative regulation of T-helper 17 cell differentiation GO:2000320 9.65 IL2 FOXP3
23 regulation of immunoglobulin production GO:0002637 9.65 TNF FOXP3
24 positive regulation of immunoglobulin production GO:0002639 9.65 IL6 IL2 IL10
25 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
26 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
27 negative regulation of lymphocyte proliferation GO:0050672 9.61 IL2 FOXP3
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B IL10
29 negative regulation of cytokine production involved in immune response GO:0002719 9.6 TNF IL10
30 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
31 positive regulation of immature T cell proliferation in thymus GO:0033092 9.57 IL1B FOXP3
32 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
33 positive regulation of plasma cell differentiation GO:1900100 9.55 IL2 IL10
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
36 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
37 vascular endothelial growth factor production GO:0010573 8.8 TNF IL6 IL1B

Molecular functions related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL2 IL1B IL10
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Sources for Orchitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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