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MCID: ORC001
MIFTS: 40

Orchitis

Categories: Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Orchitis

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MalaCards integrated aliases for Orchitis:

Name: Orchitis 12 45 15 17 74
Inflammation of Testis 12
Orchititis 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2518
MeSH 45 D009920
NCIt 51 C97145
SNOMED-CT 69 29077001
ICD10 34 N45.2
UMLS 74 C0029191
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Summaries for Orchitis

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MalaCards based summary : Orchitis, also known as inflammation of testis, is related to epididymo-orchitis and granulomatous orchitis. An important gene associated with Orchitis is GJB6 (Gap Junction Protein Beta 6), and among its related pathways/superpathways is Dendritic Cells Developmental Lineage Pathway. The drugs Isoniazid and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Orchitis is inflammation of the testes. It can also involve swelling, pains and frequent infection,... more...

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Related Diseases for Orchitis

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Diseases related to Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 epididymo-orchitis 12.5
2 granulomatous orchitis 12.4
3 acute gonococcal epididymo-orchitis 12.3
4 mumps 10.7
5 brucellosis 10.3
6 parotitis 10.2
7 bladder cancer 10.1
8 meningitis 10.1
9 encephalitis 10.1
10 testicular torsion 10.1
11 prostatitis 10.1
12 seminoma 10.1
13 hepatic infarction 10.1 EDA GJB6
14 pfeiffer syndrome 10.0
15 inguinal hernia 10.0
16 typhoid fever 10.0
17 purpura 10.0
18 syphilis 10.0
19 infertility 10.0
20 allergic encephalomyelitis 10.0
21 male infertility 10.0
22 spinal cord injury 10.0
23 epidemic typhus 10.0
24 salmonellosis 10.0
25 meningoencephalitis 10.0
26 tuberculous epididymitis 10.0
27 scrub typhus 10.0
28 relapsing polychondritis 10.0
29 pancreatitis 10.0
30 thyroiditis 10.0
31 myocarditis 10.0
32 polyarteritis nodosa 10.0
33 clouston syndrome 10.0 EDA GJB6
34 anus, imperforate 9.9
35 human immunodeficiency virus type 1 9.9
36 leukemia 9.9
37 neutropenia 9.9
38 filariasis 9.9
39 henoch-schoenlein purpura 9.9
40 pertussis 9.9
41 chlamydia 9.9
42 lymphocytic choriomeningitis 9.9
43 aseptic meningitis 9.9
44 varicocele 9.9
45 acute cystitis 9.9
46 adenocarcinoma 9.9
47 herpes simplex 9.9
48 chickenpox 9.9
49 fournier gangrene 9.9
50 malakoplakia 9.9

Graphical network of the top 20 diseases related to Orchitis:



Diseases related to Orchitis
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Symptoms & Phenotypes for Orchitis

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GenomeRNAi Phenotypes related to Orchitis according to GeneCards Suite gene sharing:

27 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.15 EPPIN
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.15 EDA IFNA2 IL12A GJA3 EPPIN HIST2H2AA3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.15 GJA3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.15 EPPIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.15 IFNA2 IL12A GJA3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.15 EPPIN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.15 EPPIN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.15 IFNA2 HIST2H2AA3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.15 EDA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.15 IFNA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.15 IL12A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.15 IFNA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.15 EDA IFNA2 IL12A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.15 EPPIN
15 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.15 EPPIN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.15 HIST2H2AA3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.15 GJA3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.15 IL12A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.15 EPPIN
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.15 EDA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.15 EDA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.15 GJA3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.15 HIST2H2AA3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.15 EPPIN HIST2H2AA3
Sources

Drugs & Therapeutics for Orchitis

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Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
4
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
5
Racepinephrine Approved Phase 3 329-65-7 838
6 Anti-Infective Agents Phase 3
7 Antiviral Agents Phase 3
8 Antitubercular Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Anti-Retroviral Agents Phase 3
11 Antimetabolites Phase 3
12 Lipid Regulating Agents Phase 3
13 Hypolipidemic Agents Phase 3
14 Neurotransmitter Agents Phase 3
15 Adrenergic Agonists Phase 3
16 Gastrointestinal Agents Phase 3
17 Adrenergic alpha-Agonists Phase 3
18 Anti-Asthmatic Agents Phase 3
19 Epinephryl borate Phase 3
20 HIV Protease Inhibitors Phase 3
21 Adrenergic beta-Agonists Phase 3
22 Antineoplastic Agents, Hormonal Phase 3
23 Hormones Phase 3
24 Peripheral Nervous System Agents Phase 3
25
protease inhibitors Phase 3
26 Respiratory System Agents Phase 3
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
28 Antiemetics Phase 3
29 glucocorticoids Phase 3
30 Vasoconstrictor Agents Phase 3
31 Mydriatics Phase 3
32 Autonomic Agents Phase 3
33 Anti-Inflammatory Agents Phase 3
34 Sympathomimetics Phase 3
35 BB 1101 Phase 3
36 Adrenergic Agents Phase 3
37 Bronchodilator Agents Phase 3
38 Pharmaceutical Solutions Phase 3
39 Hormone Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
2 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
3 Anterior Transversalis Fascia Approach Versus Preperitoneal Space Approach for Inguinal Hernia Repair in Residents Recruiting NCT02984917 Not Applicable
4 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis Active, not recruiting NCT02665182 Not Applicable

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

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Genetic Tests for Orchitis

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Anatomical Context for Orchitis

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MalaCards organs/tissues related to Orchitis:

42
Testis, Testes, Prostate, T Cells, Spinal Cord, Lymph Node, Monocytes
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Publications for Orchitis

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Articles related to Orchitis:

(show top 50) (show all 825)
# Title Authors Year
1
Severe Epididymo-Orchitis and Encephalitis Complicating Anti-PD-1 Therapy. ( 30936376 )
2019
2
Scrotal abscess consequent on syphilitic epididymo-orchitis. ( 30394857 )
2019
3
Salmonella epididymo-orchitis presenting as acute scrotum in a 2-week-old infant. ( 30407675 )
2019
4
Brucellar epididymo-orchitis: a retrospective study of 25 cases. ( 30767606 )
2019
5
Acute epididymo-orchitis due to Salmonella Typhi in a young man from Bangladesh. ( 30771193 )
2019
6
Neonatal epididymo-orchitis: An unusual manifestation of salmonellosis. ( 30817268 )
2019
7
Unusual cause for recurrent epididymo-orchitis: fistula from rectal stump to seminal vesicle. ( 30839146 )
2019
8
Correction to: Acute epididymo-orchitis due to Salmonella Typhi in a young man from Bangladesh. ( 30911901 )
2019
9
FDG PET/CT in a Case of Bilateral Tuberculous Epididymo-orchitis. ( 31107741 )
2019
10
In situ hybridization assay for the diagnosis of chagas myocarditis and orchitis in a rhesus macaque (Macaca mulatta): A case report. ( 30912150 )
2019
11
Impaired spermatogenesis, tubular wall disruption, altered blood-testis barrier composition and intratubular lymphocytes in an infertile Beagle dog - a putative case of autoimmune orchitis. ( 30403279 )
2019
12
Rare report of orchitis in a bull due to Trypanosoma evansi infection. ( 30956442 )
2019
13
Xanthogranulomatous orchitis: case report of a rare condition. ( 30976754 )
2019
14
Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. ( 29554185 )
2018
15
Granulomatous epididymo-orchitis: diagnosis by fine needle aspiration. ( 28534708 )
2018
16
Neonatal epididymo-orchitis with pyocele caused by Escherichia coli: Successful treatment with antimicrobial therapy alone. ( 29224998 )
2018
17
Non-traumatic testicular rupture following episode of epididymo-orchitis. ( 29367897 )
2018
18
Nonhealing scrotal ulceration-an unusual manifestation of TB epididymo-orchitis: case report and review of literature. ( 29375854 )
2018
19
Epididymo-orchitis caused by enteric organisms in men > 35 years old: beyond fluoroquinolones. ( 29450767 )
2018
20
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
21
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
22
Comparison of inflammatory markers between brucella and non-brucella epididymo-orchitis. ( 29697933 )
2018
23
Staphylococcus haemolyticus epididymo-orchitis and bacteraemia: a case report. ( 30275960 )
2018
24
Idiopathic granulomatous orchitis: Ultrasound and MR imaging features. ( 29415866 )
2018
25
Intratesticular pseudoaneurysm secondary to orchitis: A case report. ( 29541589 )
2018
26
Testicular plasmacytoma misdiagnosed as orchitis. ( 29866662 )
2018
27
Tuberculous Orchitis Following Intravesical Bacille Calmette-Guérin (BCG) Therapy. ( 30062077 )
2018
28
Orchitis: An unusual presentation of polyarteritis nodosa. ( 30303162 )
2018
29
Case report: Mycobacterium bovis orchitis post intravesical Bacillus Calmette Guerin. ( 30479960 )
2018
30
Brucella canis infection in a young dog with epididymitis and orchitis. ( 30516477 )
2018
31
The role of regulatory T Cells in autoimmune orchitis. ( 30569653 )
2018
32
Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. ( 28761901 )
2017
33
Coexistent duplication of urethra and a refluxing ectopic ureter presenting as recurrent epididymo-orchitis in a child. ( 28928250 )
2017
34
Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient. ( 27222288 )
2017
35
Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. ( 27246506 )
2017
36
Retrospective review of the management of epididymo-orchitis in a London-based level 3 sexual health clinic: an audit of clinical practice. ( 28201951 )
2017
37
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. ( 28205525 )
2017
38
Severe Acute Epididymo-Orchitis Complicated with Abscess and Testicular Necrosis - Case Report. ( 28246649 )
2017
39
Patients with Epididymo-Orchitis and Meteorological Impact in Taiwan: A Nationwide Population-Based Study. ( 28316630 )
2017
40
The 2016 European guideline on the management of epididymo-orchitis. ( 28632112 )
2017
41
Inferno sign in epididymo-orchitis. ( 28647767 )
2017
42
Testicular Metastasis From Prostatic Adenocarcinoma Presenting as Recurrent Epididymo-orchitis. ( 28760557 )
2017
43
Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease. ( 29034643 )
2017
44
Epididymo-orchitis caused by Histoplasma capsulatumin a Colombian patient. ( 29340471 )
2017
45
Epididymo-orchitis causing testicular infarction: a serious complication of a common disorder. ( 29423147 )
2017
46
Filariasis Orchitis-Differential for Acute Scrotum Pathology. ( 28507911 )
2017
47
Immune checkpoint inhibitors-related orchitis. ( 28039179 )
2017
48
Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not? ( 28407803 )
2017
49
Xanthogranulomatous Orchitis: Rare Case with Brief Literature Review. ( 28462167 )
2017
50
Induction of experimental autoimmune orchitis by immunization with xenogenic testicular germ cells in mice. ( 28505516 )
2017
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Variations for Orchitis

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Expression for Orchitis

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Search GEO for disease gene expression data for Orchitis.
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Pathways for Orchitis

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Pathways related to Orchitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Dendritic Cells Developmental Lineage Pathway 66
10.49 IFNA2 IL12A
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GO Terms for Orchitis

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Cellular components related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 EDA EPPIN IFNA2 IL12A RNASE10 VWA7
2 gap junction GO:0005921 8.96 GJA3 GJB6
3 connexin complex GO:0005922 8.62 GJA3 GJB6

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.96 IFNA2 IL12A
2 cell communication GO:0007154 8.62 GJA3 GJB6
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Sources for Orchitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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