MCID: ORC001
MIFTS: 38

Orchitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Orchitis

MalaCards integrated aliases for Orchitis:

Name: Orchitis 12 44 15 73
Inflammation of Testis 12
Orchititis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2518
ICD10 33 N45.2
MeSH 44 D009920
NCIt 50 C97145
SNOMED-CT 68 29077001
UMLS 73 C0029191

Summaries for Orchitis

MalaCards based summary : Orchitis, also known as inflammation of testis, is related to epididymo-orchitis and granulomatous orchitis. An important gene associated with Orchitis is PROKR1 (Prokineticin Receptor 1), and among its related pathways/superpathways is Dendritic Cells Developmental Lineage Pathway. The drugs Isoniazid and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Orchitis /�?�?ːr�?kaɪtɪs/ or orchiditis /�?�?ːrkɪ�?daɪtɪs/ (from the Ancient Greek �?ρ�?ι�? meaning... more...

Related Diseases for Orchitis

Diseases related to Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 epididymo-orchitis 12.4
2 granulomatous orchitis 12.3
3 acute gonococcal epididymo-orchitis 12.3
4 mumps 10.7
5 epididymitis 10.4
6 brucellosis 10.2
7 parotitis 10.2
8 meningitis 10.1
9 testicular torsion 10.1
10 prostatitis 10.1
11 seminoma 10.1
12 viral infectious disease 10.1
13 encephalitis 10.1
14 hepatic infarction 10.0 EDA GJB6
15 inguinal hernia 10.0
16 purpura 10.0
17 syphilis 10.0
18 infertility 10.0
19 allergic encephalomyelitis 10.0
20 clouston syndrome 9.9 EDA GJB6
21 bladder cancer 9.9
22 polyarteritis nodosa, childhood-onset 9.9
23 male infertility 9.9
24 spinal cord injury 9.9
25 meningoencephalitis 9.9
26 tuberculous epididymitis 9.9
27 scrub typhus 9.9
28 relapsing polychondritis 9.9
29 pancreatitis 9.9
30 thyroiditis 9.9
31 polyarteritis nodosa 9.9
32 autoimmune disease 9.9
33 anus, imperforate 9.9
34 neutropenia 9.9
35 salmonellosis 9.9
36 filariasis 9.9
37 pertussis 9.9
38 chlamydia 9.9
39 lymphocytic choriomeningitis 9.9
40 aseptic meningitis 9.9
41 varicocele 9.9
42 acute cystitis 9.9
43 typhoid fever 9.9
44 adenocarcinoma 9.9
45 myocarditis 9.9
46 herpes simplex 9.9
47 chickenpox 9.9
48 breast cancer 9.7
49 myositis 9.7
50 prostate cancer 9.7

Graphical network of the top 20 diseases related to Orchitis:



Diseases related to Orchitis

Symptoms & Phenotypes for Orchitis

GenomeRNAi Phenotypes related to Orchitis according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.11 EPPIN
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.11 EDA IFNA2 IL12A GJA3 EPPIN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.11 GJA3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.11 EPPIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.11 IFNA2 IL12A GJA3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.11 EPPIN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.11 EPPIN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.11 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.11 EDA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.11 IFNA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.11 IL12A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.11 IFNA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.11 EDA IFNA2 IL12A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.11 EPPIN
15 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.11 EPPIN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.11 GJA3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.11 IL12A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.11 EPPIN
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.11 EDA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.11 EDA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.11 GJA3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.11 EPPIN

Drugs & Therapeutics for Orchitis

Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
4
Racepinephrine Approved Phase 3 329-65-7 838
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
6 Anti-Bacterial Agents Phase 3
7 Lipid Regulating Agents Phase 3
8 Anti-Infective Agents Phase 3
9 Antimetabolites Phase 3
10 Hypolipidemic Agents Phase 3
11 Antitubercular Agents Phase 3
12 Anti-Asthmatic Agents Phase 3
13 Mydriatics Phase 3
14 Antineoplastic Agents, Hormonal Phase 3
15 Adrenergic beta-Agonists Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Adrenergic Agents Phase 3
18 Neurotransmitter Agents Phase 3
19 Autonomic Agents Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Sympathomimetics Phase 3
22 Respiratory System Agents Phase 3
23 Adrenergic alpha-Agonists Phase 3
24 Bronchodilator Agents Phase 3
25 Vasoconstrictor Agents Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27 Antiemetics Phase 3
28 Adrenergic Agonists Phase 3
29 HIV Protease Inhibitors Phase 3
30 Hormones Phase 3
31 BB 1101 Phase 3
32 Pharmaceutical Solutions Phase 3
33
protease inhibitors Phase 3
34 Hormone Antagonists Phase 3
35 Gastrointestinal Agents Phase 3
36 glucocorticoids Phase 3
37 Epinephryl borate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
2 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
3 Anterior Transversalis Fascia Approach Versus Preperitoneal Space Approach for Inguinal Hernia Repair in Residents Recruiting NCT02984917 Not Applicable
4 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis Active, not recruiting NCT02665182 Not Applicable

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

Genetic Tests for Orchitis

Anatomical Context for Orchitis

MalaCards organs/tissues related to Orchitis:

41
Testis, Testes, T Cells, Prostate, Spinal Cord, Thyroid, Myeloid

Publications for Orchitis

Articles related to Orchitis:

(show top 50) (show all 815)
# Title Authors Year
1
Idiopathic granulomatous orchitis: Ultrasound and MR imaging features. ( 29415866 )
2018
2
Nonhealing scrotal ulceration-an unusual manifestation of TB epididymo-orchitis: case report and review of literature. ( 29375854 )
2018
3
Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. ( 29554185 )
2018
4
Intratesticular pseudoaneurysm secondary to orchitis: A case report. ( 29541589 )
2018
5
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
6
Non-traumatic testicular rupture following episode of epididymo-orchitis. ( 29367897 )
2018
7
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
8
Epididymo-orchitis caused by enteric organisms in men >a8835A years old: beyond fluoroquinolones. ( 29450767 )
2018
9
Testicular plasmacytoma misdiagnosed as orchitis. ( 29866662 )
2018
10
Comparison of inflammatory markers between brucella and non-brucella epididymo-orchitis. ( 29697933 )
2018
11
Staphylococcus haemolyticus epididymo-orchitis and bacteraemia: a case report. ( 30275960 )
2018
12
Scrotal abscess consequent on syphilitic epididymo-orchitis. ( 30394857 )
2018
13
Salmonella epididymo-orchitis presenting as acute scrotum in a 2-week-old infant. ( 30407675 )
2018
14
Brucella canis infection in a young dog with epididymitis and orchitis. ( 30516477 )
2018
15
Tuberculous Orchitis Following Intravesical Bacille Calmette-Guérin (BCG) Therapy. ( 30062077 )
2018
16
Orchitis: An unusual presentation of polyarteritis nodosa. ( 30303162 )
2018
17
Impaired spermatogenesis, tubular wall disruption, altered blood-testis barrier composition and intratubular lymphocytes in an infertile Beagle dog - a putative case of autoimmune orchitis. ( 30403279 )
2018
18
Case report: Mycobacterium bovis orchitis post intravesical Bacillus Calmette Guerin. ( 30479960 )
2018
19
Granulomatous epididymo-orchitis: diagnosis by fine needle aspiration. ( 28534708 )
2017
20
Epididymo-orchitis caused by Histoplasma capsulatumin a Colombian patient. ( 29340471 )
2017
21
Patients with Epididymo-Orchitis and Meteorological Impact in Taiwan: A Nationwide Population-Based Study. ( 28316630 )
2017
22
Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. ( 28765008 )
2017
23
Neonatal epididymo-orchitis with pyocele caused by Escherichia coli: Successful treatment with antimicrobial therapy alone. ( 29224998 )
2017
24
Induction of experimental autoimmune orchitis by immunization with xenogenic testicular germ cells in mice. ( 28505516 )
2017
25
Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin. ( 28667125 )
2017
26
Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not? ( 28407803 )
2017
27
Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. ( 28761901 )
2017
28
Epididymo-orchitis causing testicular infarction: a serious complication of a common disorder. ( 29423147 )
2017
29
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. ( 28205525 )
2017
30
Testicular Metastasis From Prostatic Adenocarcinoma Presenting as Recurrent Epididymo-orchitis. ( 28760557 )
2017
31
Multiparametric ultrasound findings of tuberculous orchitis following bacillus Calmette-GuAcrin therapy. ( 29484062 )
2017
32
Coexistent duplication of urethra and a refluxing ectopic ureter presenting as recurrent epididymo-orchitis in a child. ( 28928250 )
2017
33
The 2016 European guideline on the management of epididymo-orchitis. ( 28632112 )
2017
34
Xanthogranulomatous Orchitis: Rare Case with Brief Literature Review. ( 28462167 )
2017
35
Xanthogranulomatous orchitis after blunt testicular trauma mimicking a testicular tumor: A case report and comparison with published cases. ( 28537048 )
2017
36
Retrospective review of the management of epididymo-orchitis in a London-based level 3 sexual health clinic: an audit of clinical practice. ( 28201951 )
2017
37
Filariasis Orchitis-Differential for Acute Scrotum Pathology. ( 28507911 )
2017
38
Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease. ( 29034643 )
2017
39
Inferno sign in epididymo-orchitis. ( 28647767 )
2017
40
Severe Acute Epididymo-Orchitis Complicated with Abscess and Testicular Necrosis - Case Report. ( 28246649 )
2017
41
Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient. ( 27222288 )
2017
42
Immune checkpoint inhibitors-related orchitis. ( 28039179 )
2017
43
An Unusual Case of Giant Cell Arteritis With Monoarthritis and Orchitis at Presentation. ( 30375529 )
2017
44
Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report. ( 27472731 )
2016
45
Re: Epidydimo-Orchitis and Anorectal Malformations: When and in Whom? ( 27628841 )
2016
46
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
47
First description of herpes simplex virus type 1 epididymo-orchitis: A new clinical form of herpes simplex virus infection during septic shock? ( 27672563 )
2016
48
The clinical and laboratory characteristics, treatments, and outcomes of patients with Brucella epididymo-orchitis (BEO) compared to those without BEO. ( 27966338 )
2016
49
Ameliorating Effect of Ginseng on Epididymo-Orchitis Inducing Alterations in Sperm Quality and Spermatogenic Cells Apoptosis following Infection by Uropathogenic Escherichia coli in Rats. ( 27602327 )
2016
50
Syphilitic orchitis mimicking a testicular tumor in a clinically occult HIV-infected young man: a case report with emphasis on a challenging pathological diagnosis. ( 26762155 )
2016

Variations for Orchitis

Expression for Orchitis

Search GEO for disease gene expression data for Orchitis.

Pathways for Orchitis

Pathways related to Orchitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 IFNA2 IL12A

GO Terms for Orchitis

Cellular components related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 EDA EPPIN IFNA2 IL12A RNASE10 VWA7
2 gap junction GO:0005921 8.96 GJA3 GJB6
3 connexin complex GO:0005922 8.62 GJA3 GJB6

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.96 IFNA2 IL12A
2 cell communication GO:0007154 8.62 GJA3 GJB6

Sources for Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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