MCID: ORC001
MIFTS: 44

Orchitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Orchitis

MalaCards integrated aliases for Orchitis:

Name: Orchitis 12 44 15 17 71
Inflammation of Testis 12
Orchititis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2518
MeSH 44 D009920
NCIt 50 C97145
SNOMED-CT 67 367112009
ICD10 32 N45.2
UMLS 71 C0029191

Summaries for Orchitis

MalaCards based summary : Orchitis, also known as inflammation of testis, is related to granulomatous orchitis and parotitis. An important gene associated with Orchitis is EPPIN (Epididymal Peptidase Inhibitor), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Antibiotics, Antitubercular and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are immune system and endocrine/exocrine gland

Wikipedia : 74 Orchitis is inflammation of the testes. It can also involve swelling, pains and frequent infection,... more...

Related Diseases for Orchitis

Diseases related to Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 868)
# Related Disease Score Top Affiliating Genes
1 granulomatous orchitis 32.4 ZAN CD68
2 parotitis 31.1 CRP CD8A CD4
3 mumps 30.8 TNF IL6 IL2 IL1B IL10
4 brucellosis 30.7 TNF IL6 IL2 IL10 CRP
5 syphilis 30.6 FOXP3 CRP CD8A CD4
6 tuberculous epididymitis 30.5 TNF CRP
7 pertussis 30.3 TNF IL6 IL1B IL10
8 mycobacterium tuberculosis 1 30.2 TNF IL10 H2AC18 CD8A CD4
9 bacteriuria 30.2 IL6 H2AC18 CRP
10 nocardiosis 30.2 TNF CRP CD4
11 chlamydia 30.2 TNF IL6 IL1B IL10 CRP
12 pfeiffer syndrome 30.2 IL2 H2AC18 CD8A CD4
13 encephalitis 30.1 TNF IL6 IL1B IL10
14 extrapulmonary tuberculosis 30.1 IL1B IL10 CRP
15 systemic autoimmune disease 30.0 IL6 CRP
16 secondary syphilis 30.0 CRP CD8A CD4
17 relapsing polychondritis 30.0 IL6 IL2 IL10 CRP
18 typhoid fever 30.0 TNF IL6 IL1B CRP
19 genital herpes 30.0 IL10 CD8A CD4
20 tertiary syphilis 29.9 TNF IL10 CRP CD8A CD4
21 posterior urethral valves 29.9 TNF IL6 ACE2
22 epidemic typhus 29.9 TNF IL10 CRP CD8A CD4
23 sleeping sickness 29.9 IL6 IL10 H2AC18
24 diverticulitis 29.9 TNF IL6 CRP
25 fasciitis 29.9 TNF IL6 IL2
26 melioidosis 29.9 TNF IL6 IL10
27 infective endocarditis 29.9 TNF IL6 CRP
28 meningoencephalitis 29.9 TNF IL6 IL10 CRP CD8A CD4
29 t cell deficiency 29.9 IL2 CD8A CD4
30 schistosomiasis 29.8 TNF IL2 IL10
31 male infertility 29.8 TNF IL6 IL1B EPPIN CRISP2
32 cryptococcosis 29.8 TNF IL10 CD8A CD4
33 aseptic meningitis 29.8 TNF IL1B IL10
34 filariasis 29.8 TNF IL6 IL2 IL10 CRP
35 purpura 29.8 TNF IL6 IL1B IL10 CRP
36 measles 29.8 TNF IL6 IL2 IL1B
37 acute cystitis 29.8 TNF IL6 IL1B IL10 H2AC18 CRP
38 scrub typhus 29.8 TNF IL1B IL10 CRP
39 lepromatous leprosy 29.8 TNF IL2 IL10
40 endocarditis 29.7 TNF IL6 IL10 CRP
41 allergic disease 29.7 TNF IL6 IL2 IL1B FOXP3
42 prostatitis 29.7 TNF IL6 IL2 IL1B IL10 FOXP3
43 gastroenteritis 29.7 TNF IL6 IL1B IL10 CRP
44 salmonellosis 29.7 TNF IL6 IL1B IL10 CD8A CD4
45 cystitis 29.7 TNF IL6 IL2 CRP
46 hantavirus hemorrhagic fever with renal syndrome 29.7 TNF IL6 CRP CD8A CD4
47 meningitis 29.6 TNF IL6 IL2 IL1B IL10 CRP
48 pulmonary tuberculosis 29.6 TNF IL6 IL2 IL10
49 acute myocarditis 29.6 TNF IL10 H2AC18 CRP CD4
50 rubella 29.6 TNF IL6 IL2 IL1B IL10

Graphical network of the top 20 diseases related to Orchitis:



Diseases related to Orchitis

Symptoms & Phenotypes for Orchitis

MGI Mouse Phenotypes related to Orchitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.07 ACE2 CD4 CD68 CD8A CRP FOXP3
2 endocrine/exocrine gland MP:0005379 10.06 CD4 CD8A CLDN11 CRISP1 FOXP3 GJB6
3 integument MP:0010771 9.81 ACE2 CD4 CD8A FOXP3 GJB6 IL10
4 no phenotypic analysis MP:0003012 9.56 CD4 CD68 CRISP1 FOXP3 GJB6 IL10
5 reproductive system MP:0005389 9.32 CLDN11 CRISP1 CRISP2 FOXP3 IL10 IL2

Drugs & Therapeutics for Orchitis

Drugs for Orchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular
2 Anti-Infective Agents
3 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis - a Randomized Controlled Trial Unknown status NCT02665182
2 Analgetics vs Analgetics and Antibiotics for Pediatric Clinical and Sonographic Orchitis or Epididymitis Recruiting NCT04489979
3 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Recruiting NCT03969979

Search NIH Clinical Center for Orchitis

Cochrane evidence based reviews: orchitis

Genetic Tests for Orchitis

Anatomical Context for Orchitis

MalaCards organs/tissues related to Orchitis:

40
Testis, Testes, Prostate, T Cells, Breast, Spinal Cord, Kidney

Publications for Orchitis

Articles related to Orchitis:

(show top 50) (show all 2239)
# Title Authors PMID Year
1
A severe complication of intravesical bacillus Calmette-Guerin: An effect of different strains. 61
33598408 2021
2
Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage. 61
33482358 2021
3
Review of COVID-19 and male genital tract. 61
33236375 2021
4
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 61
33530122 2021
5
Relevance of angiogenesis in autoimmune testis inflammation. 61
33313783 2021
6
Assessment of the Pathogenicity of Rickettsia amblyommatis, Rickettsia bellii, and Rickettsia montanensis in a Guinea Pig Model. 61
33600263 2021
7
The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma. 61
33557577 2021
8
Immune checkpoint inhibitor-related hypogonadism and infertility: a neglected issue in immuno-oncology. 61
33589529 2021
9
COVID-19 May Affect Male Fertility but is Not Sexually Transmitted: A Systematic Review. 61
33558864 2021
10
Radiological patterns of incidental epididymitis in mild-to-moderate COVID-19 patients revealed by colour Doppler ultrasound. 61
33565141 2021
11
SARS-CoV-2 infection affects the lower urinary tract and male genital system: a systematic review. 61
33595134 2021
12
Brucellosis Presenting with Febrile Pancytopenia: An Atypical Presentation of a Common Disease and Review of Brucellosis. 61
33489391 2021
13
Relationship between COVID-19 and the male reproductive system. 61
33577068 2021
14
Case Report: A Rare Case of Crimean-Congo Hemorrhagic Fever Associated with Epididymo-Orchitis. 61
33399048 2021
15
Sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection. 61
32341210 2021
16
Beyond germ cell tumors, unusual testicular and extra-testicular masses and mass-like lesions: MRI and US pictorial review. 61
33485115 2021
17
Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance. 61
32733025 2021
18
No detection of SARS-CoV-2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID-19 male patients: A perspective and urogenital evaluation. 61
33150723 2021
19
Characterization of epididymal and testicular histologic lesions and use of immunohistochemistry and PCR on formalin-fixed tissues to detect Brucella canis in male dogs. 61
33468036 2021
20
Bisphenol A exposure increases epididymal susceptibility to infection in mice. 61
33091778 2021
21
A case of acute vasitis mimicking an incarcerated inguinal hernia with subtle imaging findings. 61
33325356 2020
22
Testicular Torsion in a Rare Case of Prostatic Spindle Cell Rhabdomyosarcoma. 61
33505810 2020
23
Identification and description of mumps cases in a non-outbreak setting and evaluation of the effectiveness of mumps-containing vaccines over time. 61
32401599 2020
24
Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis. 61
33327643 2020
25
T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes. 61
33374605 2020
26
Monolateral chronicon orchitis in a stallion. 61
32602673 2020
27
Successful activation of rat T lymphocytes by sperm specific antigens in vitro. 61
33012735 2020
28
Candida urinary tract infections in adults. 61
31654220 2020
29
Testicular tuberculosis: An uncommon complication after treatment of urothelial carcinoma. 61
32983302 2020
30
Small testes: clinical characteristics and ultrasonographic findings. 61
33455146 2020
31
Acute vasitis presenting as a concerning paratesticular mass in an adolescent, a case report. 61
33102059 2020
32
Synthetic Food dyes cause testicular damage via up-regulation of pro-inflammatory cytokines and down-regulation of FSH-R and TESK-1 gene expression. 61
33565293 2020
33
Testicular pain as an unusual presentation of COVID-19: a brief review of SARS-CoV-2 and the testis. 61
32826162 2020
34
Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019: A Single-Center-Based Study in Wuhan, China. 61
33174632 2020
35
Impaired spermatogenesis in COVID-19 patients. 61
33134901 2020
36
Resolution of bilateral testicular masses after viral infection. 61
33102086 2020
37
Rectoseminal vesicle fistula after radical surgery for rectal cancer: Four case reports and a literature review. 61
33344556 2020
38
Right-sided scrotal varicocele and its association with malignancy: a multi-institutional study. 61
33151361 2020
39
Emphysematous epididymitis following hydrocelectomy. 61
33102060 2020
40
Communicating seminal vesicles leading to indirect vasal communication: A case report. 61
33101990 2020
41
A rare case of tubercular recto-prostatic urethral fistula with tuberculous orchitis. 61
33102054 2020
42
The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity. 61
32907974 2020
43
Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications in Men. 61
32713674 2020
44
The Spectrum of Testicular Pathologies Upon Scrotal Exploration for Acute Scrotum: A Retrospective Analysis. 61
33209540 2020
45
Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility. 61
33006953 2020
46
Spatial sero-prevalence of brucellosis in small ruminants of India: Nationwide cross-sectional study for the year 2017-2018. 61
33021085 2020
47
Is there any association of COVID-19 with testicular pain and epididymo-orchitis? 61
33063899 2020
48
Protective effect of Alpha-Linolenic acid on Lipopolysaccharide-Induced Orchitis in mice. 61
32453444 2020
49
A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system. 61
33009240 2020
50
Cold weather increases the risk of scrotal torsion events: results of an ecological study of acute scrotal pain in Scotland over 25 years. 61
33087783 2020

Variations for Orchitis

Expression for Orchitis

Search GEO for disease gene expression data for Orchitis.

Pathways for Orchitis

Pathways related to Orchitis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 TNF IL6 IL2 IL1B IL10 CLDN11
2
Show member pathways
12.75 TNF IL6 IL2 IL1B IL10 FOXP3
3
Show member pathways
12.59 TNF IL6 IL2 IL1B IL10 CD4
4 12.56 TNF IL2 IL1B IL10 FOXP3 CD8A
5
Show member pathways
12.54 TNF IL6 IL2 IL1B IL10 CD8A
6
Show member pathways
12.51 TNF IL6 IL2 IL1B IL10 FOXP3
7
Show member pathways
12.35 TNF IL6 IL2 IL1B CRP
8 12.33 TNF IL6 IL2 CD4
9
Show member pathways
12.32 TNF IL6 IL2 IL10
10
Show member pathways
12.26 TNF IL6 IL2 IL1B IL10
11 12.23 TNF IL6 IL1B IL10
12
Show member pathways
12.23 TNF IL6 IL2 IL1B IL10
13 12.17 TNF IL6 IL1B IL10
14 12.03 TNF IL6 IL2 IL1B
15 12 TNF IL6 IL1B IL10
16
Show member pathways
11.99 IL2 IL1B CD8A CD4
17 11.94 TNF IL6 IL1B IL10
18 11.94 TNF IL6 IL2 IL1B IL10 CD8A
19 11.87 TNF IL6 IL1B CD8A CD4
20 11.79 TNF IL6 IL1B IL10
21 11.76 TNF IL6 IL2 IL10 CD8A CD68
22
Show member pathways
11.75 TNF IL2 FOXP3
23 11.75 TNF IL2 IL1B IL10 CD8A CD4
24 11.72 TNF IL6 IL10 FOXP3
25
Show member pathways
11.68 TNF IL6 IL2 IL1B
26
Show member pathways
11.68 TNF IL6 IL2 IL1B IL10 CD4
27 11.66 TNF IL6 IL1B
28
Show member pathways
11.64 TNF IL2 CD8A
29 11.61 TNF IL6 IL1B
30 11.56 TNF IL6 IL1B IL10
31 11.55 TNF IL6 IL2
32 11.54 TNF IL6 IL1B IL10
33 11.52 TNF IL2 IL1B
34 11.5 IL2 IL10 FOXP3 CD4
35 11.49 TNF IL6 IL1B
36 11.39 TNF IL6 IL1B IL10
37
Show member pathways
11.37 TNF IL2 IL10 FOXP3
38 11.37 TNF IL6 IL2 IL1B IL10 CD8A
39 11.34 TNF IL6 IL1B IL10
40 11.33 TNF IL6 IL1B
41 11.31 TNF IL6 IL1B
42 11.07 TNF IL6 CRP
43 10.99 TNF IL1B CD68
44 10.56 TNF IL6 IL2 IL1B IL10 CD4

GO Terms for Orchitis

Cellular components related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ZAN TNF IL6 IL2 IL1B IL10
2 extracellular region GO:0005576 9.44 VWA7 TNF RNASE10 IL6 IL2 IL1B

Biological processes related to Orchitis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.09 TNF IL6 IL1B IL10 FOXP3 CD4
2 positive regulation of gene expression GO:0010628 10.07 TNF IL6 IL1B FOXP3 CRP
3 negative regulation of cell proliferation GO:0008285 10.04 IL6 IL1B IL10 GJB6 FOXP3
4 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL2 IL1B CD4
5 response to lipopolysaccharide GO:0032496 9.89 IL1B IL10 GJB6 FOXP3
6 regulation of insulin secretion GO:0050796 9.84 TNF IL6 IL1B
7 negative regulation of interleukin-6 production GO:0032715 9.83 TNF IL10 FOXP3
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNF IL6 IL2
9 response to glucocorticoid GO:0051384 9.81 TNF IL6 IL10
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 TNF IL6 IL1B IL10
11 positive regulation of interferon-gamma production GO:0032729 9.8 TNF IL2 IL1B
12 positive regulation of interleukin-8 production GO:0032757 9.79 TNF IL6 IL1B
13 cellular response to lipopolysaccharide GO:0071222 9.77 TNF IL6 IL1B IL10 CD68
14 T cell activation GO:0042110 9.75 FOXP3 CD8A CD4
15 cytokine-mediated signaling pathway GO:0019221 9.73 TNF IL6 IL2 IL1B IL10 CD4
16 positive regulation of T cell proliferation GO:0042102 9.71 IL6 IL2 IL1B CD4
17 positive regulation of JAK-STAT cascade GO:0046427 9.7 TNF IL6 IL10
18 immune response GO:0006955 9.7 TNF IL6 IL2 IL1B IL10 CD8A
19 T cell mediated immunity GO:0002456 9.67 FOXP3 CD8A
20 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
21 negative regulation of neurogenesis GO:0050768 9.67 TNF IL6 IL1B
22 negative regulation of T-helper 17 cell differentiation GO:2000320 9.65 IL2 FOXP3
23 regulation of immunoglobulin production GO:0002637 9.65 TNF FOXP3
24 positive regulation of immunoglobulin production GO:0002639 9.65 IL6 IL2 IL10
25 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
26 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
27 negative regulation of lymphocyte proliferation GO:0050672 9.61 IL2 FOXP3
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B IL10
29 negative regulation of cytokine production involved in immune response GO:0002719 9.6 TNF IL10
30 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
31 positive regulation of immature T cell proliferation in thymus GO:0033092 9.57 IL1B FOXP3
32 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
33 positive regulation of plasma cell differentiation GO:1900100 9.55 IL2 IL10
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
36 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
37 vascular endothelial growth factor production GO:0010573 8.8 TNF IL6 IL1B

Molecular functions related to Orchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL2 IL1B IL10

Sources for Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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