MCID: ORG010
MIFTS: 28

Organ System Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Organ System Benign Neoplasm

MalaCards integrated aliases for Organ System Benign Neoplasm:

Name: Organ System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060085

Summaries for Organ System Benign Neoplasm

Disease Ontology : 12 A benign neoplasm that is classified by the organ system from which it is arising from.

MalaCards based summary : Organ System Benign Neoplasm is related to gastrointestinal system benign neoplasm and endocrine organ benign neoplasm. An important gene associated with Organ System Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Proteoglycans in cancer. Related phenotypes are Reduced mammosphere formation and Increased proliferation

Related Diseases for Organ System Benign Neoplasm

Diseases related to Organ System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal system benign neoplasm 32.3 CTNNB1 KRT7 PLAG1 TP53
2 endocrine organ benign neoplasm 30.2 AIP CYP11B1 CYP11B2 IGF1 KCNJ5 MEN1
3 silent pituitary adenoma 11.2 AIP MEN1
4 null pituitary adenoma 11.2 AIP MEN1
5 chronic angina 11.2 NF2 REN
6 parathyroid transitional clear cell adenoma 11.1 MEN1 PTH
7 bronchus adenoma 11.1 POMC SST
8 hypoaldosteronism 11.1 CYP11B2 POMC REN
9 acute adrenal insufficiency 11.0 POMC REN
10 pituitary apoplexy 11.0 AIP POMC PRL
11 glomangiosarcoma 11.0 REN TP53
12 premenstrual tension 11.0 POMC PRL REN
13 scleredema adultorum 11.0 POMC PTH
14 aldosterone-producing adenoma 11.0 CYP11B2 KCNJ5 REN
15 sheehan syndrome 11.0 IGF1 POMC PRL
16 hypothyroidism, congenital, nongoitrous, 4 11.0 IGF1 POMC PRL
17 mineral metabolism disease 11.0 POMC PTH REN
18 chiasmal syndrome 11.0 POMC PRL SST
19 pituitary carcinoma 11.0 POMC PRL SST
20 galactorrhea 11.0 IGF1 PRL
21 multiple endocrine neoplasia, type iv 11.0 AIP MEN1 PRL
22 nelson syndrome 11.0 POMC PRL SST
23 cerebral convexity meningioma 11.0 NF2 TP53
24 respiratory system benign neoplasm 11.0
25 reproductive organ benign neoplasm 11.0
26 cardiovascular organ benign neoplasm 11.0
27 immune system organ benign neoplasm 11.0
28 peritoneal benign neoplasm 11.0
29 axillary lipoma 11.0
30 kidney hemangiopericytoma 11.0 CD34 REN
31 diabetes insipidus 11.0 POMC PRL REN
32 acidophil adenoma 11.0 IGF1 POMC SST
33 pineal region choriocarcinoma 11.0 CD34 IGF1
34 carney complex variant 11.0 AIP MEN1 POMC
35 pancreatic gastrinoma 11.0 MEN1 SST
36 adenohypophysitis 11.0 POMC PRL TRH
37 pituitary hormone deficiency, combined, 2 10.9 IGF1 POMC PRL
38 cloacogenic carcinoma 10.9 ENO2 POMC PTH
39 ectopic cushing syndrome 10.9 MEN1 POMC SST
40 tsh producing pituitary tumor 10.9 PRL SST
41 growth hormone secreting pituitary adenoma 10.9 AIP PRL SST
42 tibial adamantinoma 10.9 CD34 PTH
43 steroid inherited metabolic disorder 10.9 CYP11B1 CYP11B2 POMC
44 malignant pineal area germ cell neoplasm 10.9 CD34 IGF1
45 prolactin producing pituitary tumor 10.9 PRL SST TP53
46 adrenal gland hyperfunction 10.9 POMC PRL SST
47 hyperandrogenism 10.9 IGF1 POMC PRL
48 clear cell adenoma 10.9 CTNNB1 MEN1 PTH
49 adrenal rest tumor 10.9 CYP11B1 CYP11B2 POMC
50 horseshoe kidney 10.9 ENO2 KRT7 REN

Graphical network of the top 20 diseases related to Organ System Benign Neoplasm:



Diseases related to Organ System Benign Neoplasm

Symptoms & Phenotypes for Organ System Benign Neoplasm

GenomeRNAi Phenotypes related to Organ System Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD34 CYP11B1 IGF1 KCNJ5 KRT7 MEN1
2 Increased proliferation GR00094-A 9.13 MEN1 NF2 TP53

MGI Mouse Phenotypes related to Organ System Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.36 CYP11B1 AIP CYP11B2 ENO2 CTNNB1 HPSE2
2 homeostasis/metabolism MP:0005376 10.36 CYP11B1 AIP CYP11B2 CD34 CTNNB1 HPSE2
3 endocrine/exocrine gland MP:0005379 10.29 CYP11B1 AIP CYP11B2 CTNNB1 IGF1 PLAG1
4 cardiovascular system MP:0005385 10.25 IGF1 CYP11B1 AIP CYP11B2 CTNNB1 KCNJ5
5 cellular MP:0005384 10.24 CTNNB1 IGF1 CYP11B1 AIP CD34 ENO2
6 immune system MP:0005387 10.18 IGF1 CYP11B2 CD34 CTNNB1 PTH POMC
7 integument MP:0010771 9.97 CTNNB1 AIP CD34 NF2 IGF1 POMC
8 nervous system MP:0003631 9.93 IGF1 CYP11B2 ENO2 CTNNB1 POMC MEN1
9 liver/biliary system MP:0005370 9.92 AIP CYP11B2 CTNNB1 NF2 POMC MEN1
10 neoplasm MP:0002006 9.91 IGF1 AIP CD34 CTNNB1 POMC MEN1
11 renal/urinary system MP:0005367 9.65 CYP11B1 CYP11B2 CTNNB1 HPSE2 IGF1 REN
12 reproductive system MP:0005389 9.28 CTNNB1 IGF1 CYP11B2 NF2 PLAG1 MEN1

Drugs & Therapeutics for Organ System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Organ System Benign Neoplasm

Genetic Tests for Organ System Benign Neoplasm

Anatomical Context for Organ System Benign Neoplasm

Publications for Organ System Benign Neoplasm

Variations for Organ System Benign Neoplasm

Expression for Organ System Benign Neoplasm

Search GEO for disease gene expression data for Organ System Benign Neoplasm.

Pathways for Organ System Benign Neoplasm

GO Terms for Organ System Benign Neoplasm

Cellular components related to Organ System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical part of cell GO:0045177 8.8 CTNNB1 NF2 REN

Biological processes related to Organ System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.95 CTNNB1 MEN1 NF2 SST TP53
2 positive regulation of gene expression GO:0010628 9.91 CD34 CTNNB1 IGF1 PLAG1 TP53
3 cell proliferation GO:0008283 9.89 CD34 CTNNB1 IGF1 PRL TP53
4 response to nutrient levels GO:0031667 9.71 IGF1 PRL PTH
5 regulation of signaling receptor activity GO:0010469 9.63 IGF1 POMC PRL PTH SST TRH
6 ectoderm development GO:0007398 9.6 CTNNB1 NF2
7 C21-steroid hormone biosynthetic process GO:0006700 9.59 CYP11B1 CYP11B2
8 small molecule metabolic process GO:0044281 9.58 CYP11B1 CYP11B2
9 negative regulation of telomerase activity GO:0051974 9.58 MEN1 TP53
10 cellular response to potassium ion GO:0035865 9.57 CYP11B1 CYP11B2
11 glucocorticoid biosynthetic process GO:0006704 9.56 CYP11B1 CYP11B2
12 hormone-mediated apoptotic signaling pathway GO:0008628 9.48 PTH SST
13 secondary metabolite biosynthetic process GO:0044550 9.46 CYP11B1 CYP11B2
14 dehydroaustinol biosynthetic process GO:1900563 9.43 CYP11B1 CYP11B2
15 cortisol metabolic process GO:0034650 9.4 CYP11B1 CYP11B2
16 aldosterone biosynthetic process GO:0032342 9.37 CYP11B1 CYP11B2
17 austinol biosynthetic process GO:1900560 9.32 CYP11B1 CYP11B2
18 cortisol biosynthetic process GO:0034651 9.26 CYP11B1 CYP11B2
19 cellular response to peptide hormone stimulus GO:0071375 9.13 CYP11B1 CYP11B2 MEN1
20 regulation of blood pressure GO:0008217 8.92 CD34 CYP11B1 POMC REN
21 positive regulation of transcription by RNA polymerase II GO:0045944 10.07 CTNNB1 IGF1 MEN1 PLAG1 POMC PTH

Molecular functions related to Organ System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 corticosterone 18-monooxygenase activity GO:0047783 9.16 CYP11B1 CYP11B2
2 hormone activity GO:0005179 9.1 IGF1 POMC PRL PTH SST TRH
3 steroid 11-beta-monooxygenase activity GO:0004507 8.96 CYP11B1 CYP11B2

Sources for Organ System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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