MCID: ORF002
MIFTS: 41

Orofacial Cleft

Categories: Genetic diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft

MalaCards integrated aliases for Orofacial Cleft:

Name: Orofacial Cleft 12 29 6 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050567

Summaries for Orofacial Cleft

MalaCards based summary : Orofacial Cleft is related to orofacial cleft 1 and cleft lip/palate-ectodermal dysplasia syndrome. An important gene associated with Orofacial Cleft is OFC1 (Orofacial Cleft 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and TP53 Network. The drugs Hydroxocobalamin and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, endothelial and heart, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Orofacial Cleft

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15

Diseases related to Orofacial Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 orofacial cleft 1 34.8 OFC1 OFCC1
2 cleft lip/palate-ectodermal dysplasia syndrome 34.0 NECTIN1 TP63
3 cleft palate, isolated 33.6 BMP4 FOXE1 IRF6 MSX1 NECTIN1 TP63
4 cleft lip 33.3 BMP4 DLX4 IRF6 MSX1 NECTIN1 SUMO1
5 tooth agenesis 31.6 BMP4 IRF6 MSX1 SUMO1
6 cleft lip/palate 31.5 BMP4 DLX4 FOXE1 IRF6 MSX1 NECTIN1
7 isolated cleft lip 31.2 FOXE1 IRF6 MSX1 NECTIN1 TP63
8 orofacial cleft 11 12.4
9 orofacial cleft 6 12.4
10 orofacial cleft 5 12.4
11 orofacial cleft 10 12.4
12 orofacial cleft 15 12.3
13 orofacial cleft 4 12.1
14 orofacial cleft 9 12.1
15 orofacial cleft 12 12.1
16 orofacial cleft 13 12.1
17 orofacial cleft 3 12.0
18 orofacial cleft 2 12.0
19 orofacial cleft 14 12.0
20 rapp-hodgkin syndrome 11.8
21 tooth agenesis, selective, 1 11.8
22 van der woude syndrome 1 11.3
23 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 11.3
24 chromosome 1q21.1 deletion syndrome, 1.35-mb 11.2 IRF6 TP63
25 microphthalmia, syndromic 6 11.1
26 split-hand/foot malformation 6 11.1
27 split-hand/foot malformation 3 11.1
28 split-hand/foot malformation 4 11.1
29 cleft lip and alveolus 11.1 IRF6 MSX1 NECTIN1 TP63
30 physical disorder 11.0 BMP4 IRF6 MSX1
31 tooth size 11.0 BMP4 MSX1
32 otofaciocervical syndrome 1 11.0
33 microphthalmia, syndromic 11 11.0
34 otofaciocervical syndrome 2 11.0
35 hypohidrosis 10.9 MSX1 TP63
36 hemifacial microsomia with radial defects 10.9
37 split-hand/foot malformation 1 10.9
38 split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive 10.9
39 facial clefting, oblique, 1 10.9
40 split-hand/foot malformation 5 10.9
41 split hand-foot malformation 10.9
42 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.7 FOXE1 MSX1
43 synovial chondromatosis 10.5 BMP4 FGF9
44 neural tube defects 10.3
45 neural tube defects, folate-sensitive 10.2
46 gastroschisis 9.9
47 attention deficit-hyperactivity disorder 9.8
48 hypertelorism 9.8
49 lipoid congenital adrenal hyperplasia 9.8
50 corpus callosum, agenesis of 9.8

Graphical network of the top 20 diseases related to Orofacial Cleft:



Diseases related to Orofacial Cleft

Symptoms & Phenotypes for Orofacial Cleft

MGI Mouse Phenotypes related to Orofacial Cleft:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.81 BMP4 FGF9 FOXE1 IRF6 MSX1 NECTIN1
2 digestive/alimentary MP:0005381 9.5 BMP4 FGF9 FOXE1 IRF6 MSX1 SUMO1
3 vision/eye MP:0005391 9.23 OFCC1 TP63 ABCA4 BMP4 FGF9 MSX1

Drugs & Therapeutics for Orofacial Cleft

Drugs for Orofacial Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved 13422-51-0 11953898 44475014
2
Ethanol Approved Not Applicable 64-17-5 702
3
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
4
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
5
leucovorin Approved, Nutraceutical 58-05-9 143 6006
6
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical 13422-55-4
7 Vitamin B 12
8 Vitamin B Complex
9 Vitamins
10
Cobalamin Nutraceutical 13408-78-1 6438156
11 Folate Nutraceutical
12 Vitamin B12 Nutraceutical
13 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Genetics on Vitamin Metabolism in Pregnant Women Completed NCT00340366
2 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686 Not Applicable
3 Pregnancy Environment and Newborn Malformations Recruiting NCT01613638 Not Applicable
4 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Active, not recruiting NCT00341068

Search NIH Clinical Center for Orofacial Cleft

Genetic Tests for Orofacial Cleft

Genetic tests related to Orofacial Cleft:

# Genetic test Affiliating Genes
1 Orofacial Cleft 29

Anatomical Context for Orofacial Cleft

MalaCards organs/tissues related to Orofacial Cleft:

41
Whole Blood, Endothelial, Heart, Kidney

Publications for Orofacial Cleft

Articles related to Orofacial Cleft:

(show top 50) (show all 193)
# Title Authors Year
1
Soft tissue nasal asymmetry as an indicator of orofacial cleft predisposition. ( 29663709 )
2018
2
Malthus Mysterious Orofacial Cleft Correction. ( 29537879 )
2018
3
MRPL53, a New Candidate Gene for Orofacial Clefting, Identified Using an eQTL Approach. ( 29053389 )
2018
4
Orofacial cleft management by short-term surgical missions in South America: literature review. ( 29945819 )
2018
5
Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with <i>DMD, FGF13, EGFL6</i>, and Additional Loci at Xp22.2. ( 29520293 )
2018
6
Association between a single-nucleotide polymorphism in the GREM1 gene and non-syndromic orofacial cleft in the Chinese population. ( 29149498 )
2018
7
A functional polymorphism in the pre-miR-146a gene is associated with the risk of nonsyndromic orofacial cleft. ( 29484780 )
2018
8
Novel IRF6 Mutations Detected in Orofacial Cleft Patients by Targeted Massively Parallel Sequencing. ( 27834299 )
2017
9
Determinants of orofacial clefting I: Effects of 5-Aza-2'-deoxycytidine on cellular processes and gene expression during development of the first branchial arch. ( 27915011 )
2017
10
Distinct DNA methylation profiles in subtypes of orofacial cleft. ( 28603561 )
2017
11
Determinants of orofacial clefting II: Effects of 5-Aza-2'-deoxycytidine on gene methylation during development of the first branchial arch. ( 27923600 )
2017
12
Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. ( 28081210 )
2017
13
Identification of 16q21 as a modifier of nonsyndromic orofacial cleft phenotypes. ( 29124805 )
2017
14
Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate. ( 28029220 )
2017
15
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. ( 28054174 )
2017
16
Are people with an orofacial cleft at a higher risk of dental caries? A systematic review and meta-analysis. ( 28684841 )
2017
17
Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip A+ Cleft Palate and Cleft Palate Only. ( 28087736 )
2017
18
Association between PAX7 and NTN1 gene polymorphisms and nonsyndromic orofacial clefts in a northern Chinese population. ( 28489749 )
2017
19
New insights in orofacial cleft: epidemiological and genetic studies on italian samples. ( 28757931 )
2017
20
Validity and reliability of the COHIP-SF in Australian children with orofacial cleft. ( 28833655 )
2017
21
Prenatal Treatment with Dexamethasone in Suspected Congenital Adrenal Hyperplasia and Orofacial Cleft: a Case Report and Review of the Literature. ( 28845624 )
2017
22
Prevalence and Characteristics of Developmental Dental Anomalies in Iranian Orofacial Cleft Patients. ( 29034274 )
2017
23
Risk factors for orofacial clefts in India: A case-control study. ( 28766884 )
2017
24
Rs12941170 at SOX9 gene associated with orofacial clefts in Chinese. ( 28068523 )
2017
25
Hypertelorism and Orofacial Clefting Revisited: An Anthropometric Investigation. ( 27505181 )
2017
26
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis. ( 27364370 )
2016
27
Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies. ( 27215617 )
2016
28
Lamotrigine use in pregnancy and risk of orofacial cleft and other congenital anomalies. ( 27053714 )
2016
29
Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft. ( 27511275 )
2016
30
IRF6 mutation screening in non-syndromic orofacial clefting: analysis of 1521 families. ( 26346622 )
2016
31
Genetic variation of FOXE1 and risk for orofacial clefts in a California population. ( 27604706 )
2016
32
Can we predict orofacial cleft in future pregnancy? ( 27546542 )
2016
33
Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants. ( 27279979 )
2016
34
Correction: Prevalence of Gastroschisis, Omphalocele, Spina Bifida and Orofacial Clefts of Neonates from January 2000 to December 2010 in Leipzig, Saxony, Saxony-Anhalt and Germany. ( 27533496 )
2016
35
The incidence of Orofacial Cleft in live births in New Zealand. ( 27538040 )
2016
36
TPM1 polymorphisms and nonsyndromic orofacial clefts susceptibility in a Chinese Han population. ( 26792422 )
2016
37
FOXE1 polymorphisms and non-syndromic orofacial cleft susceptibility in a Chinese Han population. ( 26728781 )
2016
38
Nucleotide Variants of the BH4 Biosynthesis Pathway Gene GCH1 and the Risk of Orofacial Clefts. ( 26215833 )
2016
39
Lack of Association between Missense Variants in GRHL3 (rs2486668 and rs545809) and Susceptibility to Non-Syndromic Orofacial Clefts in a Han Chinese Population. ( 27459192 )
2016
40
Nonsynonymous variants in MYH9 and ABCA4 are the most frequent risk loci associated with nonsyndromic orofacial cleft in Taiwanese population. ( 27527345 )
2016
41
Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010. ( 27191125 )
2016
42
Three-dimensional evaluation of surgical techniques in neonates with orofacial cleft. ( 28299266 )
2016
43
Tooth agenesis and orofacial clefting: genetic brothers in arms? ( 27699475 )
2016
44
MTHFD1 gene polymorphisms as risk factors involved in orofacial cleft: an independent case-control study and a meta-analysis. ( 26221324 )
2015
45
Weight Gain Pattern of Infants with Orofacial Cleft on Three Types of Feeding Techniques. ( 25650232 )
2015
46
Evidence of olfactory deficits as part of the phenotypic spectrum of nonsyndromic orofacial clefting. ( 25534055 )
2015
47
Psychotropic drug use in adolescents born with an orofacial cleft: a population-based study. ( 25838502 )
2015
48
Evaluation of the association of polymorphisms in EYA1, environmental factors, and non-syndromic orofacial clefts in Western Han Chinese. ( 25640282 )
2015
49
The accuracy of prenatal ultrasound in determining the type of orofacial cleft. ( 25721357 )
2015
50
Association between FOXE1 and non-syndromic orofacial clefts in a northeastern Chinese population. ( 26100861 )
2015

Variations for Orofacial Cleft

ClinVar genetic disease variations for Orofacial Cleft:

6
(show all 46)
# Gene Variation Type Significance SNP ID Assembly Location
1 BMP4 NM_001202.5(BMP4): c.455T> C (p.Val152Ala) single nucleotide variant Benign/Likely benign rs17563 GRCh37 Chromosome 14, 54417522: 54417522
2 BMP4 NM_001202.5(BMP4): c.455T> C (p.Val152Ala) single nucleotide variant Benign/Likely benign rs17563 GRCh38 Chromosome 14, 53950804: 53950804
3 BMP4 NM_001202.5(BMP4): c.*148_*149insT insertion Uncertain significance rs796563569 GRCh38 Chromosome 14, 53949883: 53949884
4 BMP4 NM_001202.5(BMP4): c.*148_*149insT insertion Uncertain significance rs796563569 GRCh37 Chromosome 14, 54416601: 54416602
5 BMP4 NM_001202.5(BMP4): c.*148A> T single nucleotide variant Likely benign rs76335800 GRCh38 Chromosome 14, 53949884: 53949884
6 BMP4 NM_001202.5(BMP4): c.*148A> T single nucleotide variant Likely benign rs76335800 GRCh37 Chromosome 14, 54416602: 54416602
7 BMP4 NM_001202.5(BMP4): c.*143A> T single nucleotide variant Uncertain significance rs750395429 GRCh38 Chromosome 14, 53949889: 53949889
8 BMP4 NM_001202.5(BMP4): c.*143A> T single nucleotide variant Uncertain significance rs750395429 GRCh37 Chromosome 14, 54416607: 54416607
9 BMP4 NM_001202.5(BMP4): c.*251C> T single nucleotide variant Uncertain significance rs573118445 GRCh38 Chromosome 14, 53949781: 53949781
10 BMP4 NM_001202.5(BMP4): c.*251C> T single nucleotide variant Uncertain significance rs573118445 GRCh37 Chromosome 14, 54416499: 54416499
11 BMP4 NM_001202.5(BMP4): c.*150delG deletion Uncertain significance rs878985651 GRCh38 Chromosome 14, 53949882: 53949882
12 BMP4 NM_001202.5(BMP4): c.*150delG deletion Uncertain significance rs878985651 GRCh37 Chromosome 14, 54416600: 54416600
13 BMP4 NM_001202.5(BMP4): c.*148_*149insAAT insertion Uncertain significance rs796563569 GRCh38 Chromosome 14, 53949883: 53949884
14 BMP4 NM_001202.5(BMP4): c.*148_*149insAAT insertion Uncertain significance rs796563569 GRCh37 Chromosome 14, 54416601: 54416602
15 BMP4 NM_001202.5(BMP4): c.*88C> T single nucleotide variant Likely benign rs74054236 GRCh38 Chromosome 14, 53949944: 53949944
16 BMP4 NM_001202.5(BMP4): c.*88C> T single nucleotide variant Likely benign rs74054236 GRCh37 Chromosome 14, 54416662: 54416662
17 BMP4 NM_001202.5(BMP4): c.*35C> G single nucleotide variant Uncertain significance rs886050540 GRCh38 Chromosome 14, 53949997: 53949997
18 BMP4 NM_001202.5(BMP4): c.*35C> G single nucleotide variant Uncertain significance rs886050540 GRCh37 Chromosome 14, 54416715: 54416715
19 BMP4 NM_001202.5(BMP4): c.-146T> C single nucleotide variant Likely benign rs73267467 GRCh37 Chromosome 14, 54423281: 54423281
20 BMP4 NM_001202.5(BMP4): c.-146T> C single nucleotide variant Likely benign rs73267467 GRCh38 Chromosome 14, 53956563: 53956563
21 BMP4 NM_001202.5(BMP4): c.-342G> A single nucleotide variant Uncertain significance rs778139957 GRCh37 Chromosome 14, 54423477: 54423477
22 BMP4 NM_001202.5(BMP4): c.-342G> A single nucleotide variant Uncertain significance rs778139957 GRCh38 Chromosome 14, 53956759: 53956759
23 BMP4 NM_001202.5(BMP4): c.*272A> G single nucleotide variant Uncertain significance rs568281464 GRCh38 Chromosome 14, 53949760: 53949760
24 BMP4 NM_001202.5(BMP4): c.*272A> G single nucleotide variant Uncertain significance rs568281464 GRCh37 Chromosome 14, 54416478: 54416478
25 BMP4 NM_001202.5(BMP4): c.*149G> A single nucleotide variant Uncertain significance rs74495140 GRCh38 Chromosome 14, 53949883: 53949883
26 BMP4 NM_001202.5(BMP4): c.*149G> A single nucleotide variant Uncertain significance rs74495140 GRCh37 Chromosome 14, 54416601: 54416601
27 BMP4 NM_001202.5(BMP4): c.*148_*149delAG deletion Uncertain significance rs140085940 GRCh38 Chromosome 14, 53949883: 53949884
28 BMP4 NM_001202.5(BMP4): c.*148_*149delAG deletion Uncertain significance rs140085940 GRCh37 Chromosome 14, 54416601: 54416602
29 BMP4 NM_001202.5(BMP4): c.*146_*148dupAAA duplication Uncertain significance rs796563569 GRCh38 Chromosome 14, 53949884: 53949886
30 BMP4 NM_001202.5(BMP4): c.*146_*148dupAAA duplication Uncertain significance rs796563569 GRCh37 Chromosome 14, 54416602: 54416604
31 BMP4 NM_001202.5(BMP4): c.370+12C> T single nucleotide variant Uncertain significance rs368426865 GRCh37 Chromosome 14, 54418559: 54418559
32 BMP4 NM_001202.5(BMP4): c.370+12C> T single nucleotide variant Uncertain significance rs368426865 GRCh38 Chromosome 14, 53951841: 53951841
33 BMP4 NM_001202.5(BMP4): c.288A> G (p.Glu96=) single nucleotide variant Uncertain significance rs886050541 GRCh37 Chromosome 14, 54418653: 54418653
34 BMP4 NM_001202.5(BMP4): c.288A> G (p.Glu96=) single nucleotide variant Uncertain significance rs886050541 GRCh38 Chromosome 14, 53951935: 53951935
35 BMP4 NM_001202.5(BMP4): c.224A> G (p.Lys75Arg) single nucleotide variant Uncertain significance rs777501416 GRCh37 Chromosome 14, 54418717: 54418717
36 BMP4 NM_001202.5(BMP4): c.224A> G (p.Lys75Arg) single nucleotide variant Uncertain significance rs777501416 GRCh38 Chromosome 14, 53951999: 53951999
37 BMP4 NM_001202.5(BMP4): c.215A> G (p.Gln72Arg) single nucleotide variant Uncertain significance rs771047931 GRCh37 Chromosome 14, 54418726: 54418726
38 BMP4 NM_001202.5(BMP4): c.215A> G (p.Gln72Arg) single nucleotide variant Uncertain significance rs771047931 GRCh38 Chromosome 14, 53952008: 53952008
39 BMP4 NM_001202.5(BMP4): c.*148_*149insAT insertion Uncertain significance rs796563569 GRCh37 Chromosome 14, 54416601: 54416602
40 BMP4 NM_001202.5(BMP4): c.*148_*149insAT insertion Uncertain significance rs796563569 GRCh38 Chromosome 14, 53949883: 53949884
41 BMP4 NM_001202.5(BMP4): c.*148_*149insAG insertion Uncertain significance rs796563569 GRCh38 Chromosome 14, 53949883: 53949884
42 BMP4 NM_001202.5(BMP4): c.*148_*149insAG insertion Uncertain significance rs796563569 GRCh37 Chromosome 14, 54416601: 54416602
43 BMP4 NM_001202.5(BMP4): c.*145_*149delAAAAG deletion Uncertain significance rs886050539 GRCh38 Chromosome 14, 53949883: 53949887
44 BMP4 NM_001202.5(BMP4): c.*145_*149delAAAAG deletion Uncertain significance rs886050539 GRCh37 Chromosome 14, 54416601: 54416605
45 BMP4 NM_001202.5(BMP4): c.*131A> T single nucleotide variant Uncertain significance rs76149166 GRCh38 Chromosome 14, 53949901: 53949901
46 BMP4 NM_001202.5(BMP4): c.*131A> T single nucleotide variant Uncertain significance rs76149166 GRCh37 Chromosome 14, 54416619: 54416619

Expression for Orofacial Cleft

Search GEO for disease gene expression data for Orofacial Cleft.

Pathways for Orofacial Cleft

Pathways related to Orofacial Cleft according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 BMP4 IRF6 MSX1 TP63
2
Show member pathways
10.5 SUMO1 TP63
3 9.86 IRF6 TP63

GO Terms for Orofacial Cleft

Biological processes related to Orofacial Cleft according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.91 BMP4 FOXE1 MSX1 SUMO1 TP63
2 roof of mouth development GO:0060021 9.61 FOXE1 MSX1 SUMO1
3 pituitary gland development GO:0021983 9.58 BMP4 MSX1
4 positive regulation of mesenchymal cell proliferation GO:0002053 9.57 FGF9 TP63
5 hair follicle morphogenesis GO:0031069 9.56 FOXE1 TP63
6 anatomical structure formation involved in morphogenesis GO:0048646 9.55 BMP4 TP63
7 camera-type eye morphogenesis GO:0048593 9.54 BMP4 NECTIN1
8 odontogenesis of dentin-containing tooth GO:0042475 9.54 BMP4 MSX1 TP63
9 monocyte differentiation GO:0030224 9.52 BMP4 MYH9
10 negative regulation of transcription by RNA polymerase II GO:0000122 9.5 BMP4 DLX4 FGF9 FOXE1 MSX1 SUMO1
11 keratinocyte proliferation GO:0043616 9.49 IRF6 TP63
12 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.48 BMP4 MSX1
13 smooth muscle tissue development GO:0048745 9.46 BMP4 TP63
14 cranial skeletal system development GO:1904888 9.4 FOXE1 TP63
15 embryonic hindlimb morphogenesis GO:0035116 9.33 BMP4 MSX1 TP63
16 BMP signaling pathway involved in heart development GO:0061312 9.32 BMP4 MSX1
17 cloacal septation GO:0060197 9.26 BMP4 TP63
18 embryonic limb morphogenesis GO:0030326 8.92 BMP4 FGF9 MSX1 TP63

Molecular functions related to Orofacial Cleft according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.02 DLX4 FOXE1 IRF6 MSX1 TP63

Sources for Orofacial Cleft

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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