OFC12
MCID: ORF020
MIFTS: 16

Orofacial Cleft 12 (OFC12)

Categories: Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft 12

MalaCards integrated aliases for Orofacial Cleft 12:

Name: Orofacial Cleft 12 58 12 13 74
Cleft Lip with or Without Cleft Palate, Nonsyndromic, 12 58
Nonsyndromic Cleft Lip with or Without Cleft Palate 12 12
Ofc12 58

Classifications:



External Ids:

Disease Ontology 12 DOID:0080405
OMIM 58 612858
MedGen 43 C2748505
UMLS 74 C2748505

Summaries for Orofacial Cleft 12

Disease Ontology : 12 An orofacial cleft that has material basis in variation in the chromosome region 8q24.3.

MalaCards based summary : Orofacial Cleft 12, also known as cleft lip with or without cleft palate, nonsyndromic, 12, is related to orofacial cleft. An important gene associated with Orofacial Cleft 12 is OFC12 (Orofacial Cleft 12). The drugs Omalizumab and Anti-Allergic Agents have been mentioned in the context of this disorder.

Description from OMIM: 612858

Related Diseases for Orofacial Cleft 12

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15 Orofacial Cleft 8

Diseases related to Orofacial Cleft 12 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orofacial cleft 11.3

Symptoms & Phenotypes for Orofacial Cleft 12

Clinical features from OMIM:

612858

Drugs & Therapeutics for Orofacial Cleft 12

Drugs for Orofacial Cleft 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 1, Phase 2 242138-07-4
2 Anti-Allergic Agents Phase 1, Phase 2
3 Anti-Asthmatic Agents Phase 1, Phase 2
4 Respiratory System Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Peanut Reactivity Reduced by Oral Tolerance in an Anti-IgE Clinical Trial Active, not recruiting NCT01781637 Phase 1, Phase 2 Omalizumab;placebo

Search NIH Clinical Center for Orofacial Cleft 12

Genetic Tests for Orofacial Cleft 12

Anatomical Context for Orofacial Cleft 12

Publications for Orofacial Cleft 12

Variations for Orofacial Cleft 12

Expression for Orofacial Cleft 12

Search GEO for disease gene expression data for Orofacial Cleft 12.

Pathways for Orofacial Cleft 12

GO Terms for Orofacial Cleft 12

Sources for Orofacial Cleft 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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