OFC12
MCID: ORF020
MIFTS: 14

Orofacial Cleft 12 (OFC12)

Categories: Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft 12

MalaCards integrated aliases for Orofacial Cleft 12:

Name: Orofacial Cleft 12 57 12 13 70
Cleft Lip with or Without Cleft Palate, Nonsyndromic, 12 57
Nonsyndromic Cleft Lip with or Without Cleft Palate 12 12
Ofc12 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0080405
OMIM® 57 612858
OMIM Phenotypic Series 57 PS119530
MedGen 41 C2748505
UMLS 70 C2748505

Summaries for Orofacial Cleft 12

Disease Ontology : 12 An orofacial cleft that has material basis in variation in the chromosome region 8q24.3.

MalaCards based summary : Orofacial Cleft 12, also known as cleft lip with or without cleft palate, nonsyndromic, 12, is related to orofacial cleft. An important gene associated with Orofacial Cleft 12 is OFC12 (Orofacial Cleft 12).

More information from OMIM: 612858 PS119530

Related Diseases for Orofacial Cleft 12

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15 Orofacial Cleft 8

Diseases related to Orofacial Cleft 12 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orofacial cleft 10.9

Symptoms & Phenotypes for Orofacial Cleft 12

Clinical features from OMIM®:

612858 (Updated 05-Apr-2021)

Drugs & Therapeutics for Orofacial Cleft 12

Search Clinical Trials , NIH Clinical Center for Orofacial Cleft 12

Genetic Tests for Orofacial Cleft 12

Anatomical Context for Orofacial Cleft 12

Publications for Orofacial Cleft 12

Articles related to Orofacial Cleft 12:

# Title Authors PMID Year
1
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 57
22863734 2012
2
Replication of novel susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 in Estonian and Lithuanian patients. 57
19839039 2009
3
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. 57
19270707 2009
4
SUMO1 haploinsufficiency leads to cleft lip and palate. 57
16990542 2006
5
Damage to Orbitofrontal Areas 12 and 13, but Not Area 14, Results in Blunted Attention and Arousal to Socioemotional Stimuli in Rhesus Macaques. 61
33093825 2020

Variations for Orofacial Cleft 12

Expression for Orofacial Cleft 12

Search GEO for disease gene expression data for Orofacial Cleft 12.

Pathways for Orofacial Cleft 12

GO Terms for Orofacial Cleft 12

Sources for Orofacial Cleft 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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