MCID: ORF020
MIFTS: 14

Orofacial Cleft 12

Categories: Genetic diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft 12

MalaCards integrated aliases for Orofacial Cleft 12:

Name: Orofacial Cleft 12 57 13 73
Cleft Lip with or Without Cleft Palate, Nonsyndromic, 12 57
Ofc12 57

Classifications:



External Ids:

OMIM 57 612858
MedGen 42 C2748505
UMLS 73 C2748505

Summaries for Orofacial Cleft 12

MalaCards based summary : Orofacial Cleft 12, also known as cleft lip with or without cleft palate, nonsyndromic, 12, is related to orofacial cleft. An important gene associated with Orofacial Cleft 12 is OFC12 (Orofacial Cleft 12). The drugs Omalizumab and Anti-Allergic Agents have been mentioned in the context of this disorder.

Description from OMIM: 612858

Related Diseases for Orofacial Cleft 12

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15

Diseases related to Orofacial Cleft 12 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orofacial cleft 11.1

Symptoms & Phenotypes for Orofacial Cleft 12

Clinical features from OMIM:

612858

Drugs & Therapeutics for Orofacial Cleft 12

Drugs for Orofacial Cleft 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 1, Phase 2 242138-07-4
2 Anti-Allergic Agents Phase 1, Phase 2
3 Anti-Asthmatic Agents Phase 1, Phase 2
4 Respiratory System Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Peanut Reactivity Reduced by Oral Tolerance in an Anti-IgE Clinical Trial Active, not recruiting NCT01781637 Phase 1, Phase 2 Omalizumab;placebo

Search NIH Clinical Center for Orofacial Cleft 12

Genetic Tests for Orofacial Cleft 12

Anatomical Context for Orofacial Cleft 12

Publications for Orofacial Cleft 12

Variations for Orofacial Cleft 12

Expression for Orofacial Cleft 12

Search GEO for disease gene expression data for Orofacial Cleft 12.

Pathways for Orofacial Cleft 12

GO Terms for Orofacial Cleft 12

Sources for Orofacial Cleft 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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