MCID: ORF050
MIFTS: 16

Orofacial Cleft 2

Categories: Genetic diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft 2

MalaCards integrated aliases for Orofacial Cleft 2:

Name: Orofacial Cleft 2 57 73
Orofacial Cleft-2 57 13
Cleft Lip with or Without Cleft Palate, Nonsyndromic, 2 57
Otofaciocervical Syndrome 2 73
Ofc2 57

Classifications:



External Ids:

OMIM 57 602966
MedGen 42 C1864323

Summaries for Orofacial Cleft 2

MalaCards based summary : Orofacial Cleft 2, also known as orofacial cleft-2, is related to orofacial cleft and otofaciocervical syndrome 2. An important gene associated with Orofacial Cleft 2 is OFC2 (Orofacial Cleft 2). The drugs Histamine and Omalizumab have been mentioned in the context of this disorder.

Description from OMIM: 602966

Related Diseases for Orofacial Cleft 2

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15

Diseases related to Orofacial Cleft 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orofacial cleft 11.5
2 otofaciocervical syndrome 2 11.1

Symptoms & Phenotypes for Orofacial Cleft 2

Clinical features from OMIM:

602966

Drugs & Therapeutics for Orofacial Cleft 2

Drugs for Orofacial Cleft 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
2
Omalizumab Approved, Investigational Phase 2 242138-07-4
3 Anti-Allergic Agents Phase 2
4 Anti-Asthmatic Agents Phase 2
5
Histamine Phosphate Phase 2 51-74-1 65513
6 Respiratory System Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Omalizumab in the Treatment of Peanut Allergy Completed NCT00949078 Phase 2 omalizumab

Search NIH Clinical Center for Orofacial Cleft 2

Genetic Tests for Orofacial Cleft 2

Anatomical Context for Orofacial Cleft 2

Publications for Orofacial Cleft 2

Variations for Orofacial Cleft 2

Expression for Orofacial Cleft 2

Search GEO for disease gene expression data for Orofacial Cleft 2.

Pathways for Orofacial Cleft 2

GO Terms for Orofacial Cleft 2

Sources for Orofacial Cleft 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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