MCID: ORF049
MIFTS: 17

Orofacial Cleft 3

Categories: Genetic diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft 3

MalaCards integrated aliases for Orofacial Cleft 3:

Name: Orofacial Cleft 3 57 73
Orofacial Cleft-3 57 13
Cleft Lip with or Without Cleft Palate, Nonsyndromic, 3 57
Ofc3 57

Characteristics:

OMIM:

57
Inheritance:
? autosomal dominant (19q13)


Classifications:



External Ids:

OMIM 57 600757
MedGen 42 C1833369
UMLS 73 C1833369

Summaries for Orofacial Cleft 3

MalaCards based summary : Orofacial Cleft 3, also known as orofacial cleft-3, is related to orofacial cleft. An important gene associated with Orofacial Cleft 3 is OFC3 (Orofacial Cleft 3). The drugs Omalizumab and Histamine have been mentioned in the context of this disorder. Related phenotype is abnormality of the face.

Description from OMIM: 600757

Related Diseases for Orofacial Cleft 3

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15

Diseases related to Orofacial Cleft 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orofacial cleft 11.1

Symptoms & Phenotypes for Orofacial Cleft 3

Symptoms via clinical synopsis from OMIM:

57
Facies:
orofacial cleft


Clinical features from OMIM:

600757

Human phenotypes related to Orofacial Cleft 3:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the face 32 HP:0000271

Drugs & Therapeutics for Orofacial Cleft 3

Drugs for Orofacial Cleft 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
3
Histamine Phosphate Phase 2 51-74-1 65513
4 Respiratory System Agents Phase 2
5 Anti-Allergic Agents Phase 2
6 Anti-Asthmatic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Omalizumab in the Treatment of Peanut Allergy Completed NCT00949078 Phase 2 omalizumab

Search NIH Clinical Center for Orofacial Cleft 3

Genetic Tests for Orofacial Cleft 3

Anatomical Context for Orofacial Cleft 3

Publications for Orofacial Cleft 3

Variations for Orofacial Cleft 3

Expression for Orofacial Cleft 3

Search GEO for disease gene expression data for Orofacial Cleft 3.

Pathways for Orofacial Cleft 3

GO Terms for Orofacial Cleft 3

Sources for Orofacial Cleft 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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