OFC8
MCID: ORF016
MIFTS: 39

Orofacial Cleft 8 (OFC8)

Categories: Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Orofacial Cleft 8

MalaCards integrated aliases for Orofacial Cleft 8:

Name: Orofacial Cleft 8 56 12 73 29 6 15
Cleft Lip with or Without Cleft Palate, Nonsyndromic, 8 56 73
Ofc8 56 73
Non-Syndromic Cleft Lip with or Without Cleft Palate 8 73
Non-Syndromic Cleft Lip/palate 8 73
Orofacial Cleft, Type 8 39

Classifications:



External Ids:

Disease Ontology 12 DOID:0080401
OMIM 56 618149
OMIM Phenotypic Series 56 PS119530
MeSH 43 D002971

Summaries for Orofacial Cleft 8

UniProtKB/Swiss-Prot : 73 Orofacial cleft 8: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.

MalaCards based summary : Orofacial Cleft 8, also known as cleft lip with or without cleft palate, nonsyndromic, 8, is related to rapp-hodgkin syndrome and split-hand/foot malformation 1. An important gene associated with Orofacial Cleft 8 is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Direct p53 effectors and Neural Crest Differentiation. Related phenotypes are craniofacial and digestive/alimentary

Disease Ontology : 12 An orofacial cleft that has material basis in heterozygous mutation in the TP63 gene on chromosome 3q28.

OMIM : 56 Orofacial cleft-8 (OFC8) is characterized by unilateral or bilateral cleft lip (Leoyklang et al., 2006; Basha et al., 2018). (618149)

Related Diseases for Orofacial Cleft 8

Diseases in the Orofacial Cleft family:

Orofacial Cleft 1 Orofacial Cleft 11
Orofacial Cleft 3 Orofacial Cleft 2
Orofacial Cleft 4 Orofacial Cleft 6
Orofacial Cleft 5 Orofacial Cleft 9
Orofacial Cleft 12 Orofacial Cleft 10
Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 15 Orofacial Cleft 8

Diseases related to Orofacial Cleft 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 rapp-hodgkin syndrome 32.6 TP63 DLX6 DLX5
2 split-hand/foot malformation 1 10.4 TP63 DLX5
3 cleft lip and alveolus 10.4 TP63 IRF6
4 bartsocas-papas syndrome 10.4 TP63 IRF6
5 isolated cleft lip 10.3 TP63 IRF6
6 ulcerative stomatitis 10.3 TP73 TP63
7 syngnathia 10.3 IRF6 DLX6
8 isolated split hand-split foot malformation 10.3 TP63 DLX6 DLX5
9 split-hand/foot malformation 5 10.3 TP63 DLX6 DLX5
10 split-hand/foot malformation 2 10.3 TP63 DLX6 DLX5
11 split-hand/foot malformation 3 10.3 TP63 DLX6 DLX5
12 erythrokeratoderma 10.3 LORICRIN FLG
13 cleft lip/palate 10.3 TP63 LOC111162620 IRF6
14 split-hand/foot malformation 6 10.3 TP63 DLX6 DLX5
15 split-hand/foot malformation 4 10.3 TP63 DLX6 DLX5
16 split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive 10.3 TP63 DLX6 DLX5
17 split hand-foot malformation 10.3 TP63 DLX6 DLX5
18 stomach carcinoma in situ 10.2 LORICRIN FLG
19 dermatitis, atopic, 2 10.2 LORICRIN FLG
20 hyaline fibromatosis syndrome 10.2 LORICRIN EDAR CDH3
21 irritant dermatitis 10.1 LORICRIN FLG
22 epstein-barr virus-associated gastric carcinoma 10.1 TP73 FLG
23 hair disease 10.1 LORICRIN EDAR CDH3
24 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.1 TP63 LOC111162620 DLX6 DLX5
25 mucinous stomach adenocarcinoma 10.1 MLANA CDH3
26 orofacial cleft 4 10.1 TP63 NOTCH1 DLX6
27 ankyloblepharon-ectodermal defects-cleft lip/palate 10.0 TP63 IRF6 EDAR DLX5
28 heart, malformation of 10.0 NOTCH1 JAG1
29 nodular regenerative hyperplasia 10.0 NOTCH1 JAG1
30 ciliary body cancer 10.0 TYR MLANA
31 halo nevi 10.0 TYR MLANA
32 melanoacanthoma 10.0 TYR MLANA
33 sarcomatoid transitional cell carcinoma 9.9 TYR MLANA
34 diffuse meningeal melanocytosis 9.9 TYR MLANA
35 epithelioid cell melanoma 9.9 TYR MLANA
36 spinal cord melanoma 9.9 TYR MLANA
37 mucoepidermoid carcinoma 9.9 TP63 NOTCH1 CDH3
38 actinic keratosis 9.9 TYR TP63 FLG
39 malignant spindle cell melanoma 9.8 TYR MLANA
40 tooth agenesis 9.8 TP63 IRF6 EDAR DLX5 CDH3
41 chromosome 2q35 duplication syndrome 9.8 TP63 IRF6 DLX6 DLX5 BMP7
42 cleft palate, isolated 9.7 TP63 IRF6 DLX6 DLX5 BMP7
43 root caries 9.7 SNCA SMARCA4
44 nodular malignant melanoma 9.7 TYR MLANA
45 integumentary system disease 9.7 TYR LORICRIN FLG
46 hajdu-cheney syndrome 9.7 NOTCH1 JAG1
47 orofacial cleft 9.6 TP63 LOC111162620 IRF6 DLX6 DLX5 BMP7
48 spondylocostal dysostosis 3, autosomal recessive 9.5 NOTCH1 JAG1
49 ventricular septal defect 9.3 SMARCA4 NOTCH1 JAG1
50 basal cell carcinoma 9.3 TYR TP63 NOTCH1 CDH3

Graphical network of the top 20 diseases related to Orofacial Cleft 8:



Diseases related to Orofacial Cleft 8

Symptoms & Phenotypes for Orofacial Cleft 8

Clinical features from OMIM:

618149

MGI Mouse Phenotypes related to Orofacial Cleft 8:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.29 BMP7 DLX5 DLX6 EDAR IRF6 JAG1
2 digestive/alimentary MP:0005381 10.28 BMP7 DLX5 DLX6 EDAR IRF6 JAG1
3 cardiovascular system MP:0005385 10.27 BMP7 DLX5 EDAR JAG1 NOTCH1 SMARCA4
4 growth/size/body region MP:0005378 10.27 BMP7 DLX5 DLX6 EDAR IRF6 JAG1
5 integument MP:0010771 10.27 BMP7 CDH3 DLX5 DLX6 EDAR IRF6
6 cellular MP:0005384 10.26 DLX5 EDAR IRF6 JAG1 NOTCH1 SMARCA4
7 embryo MP:0005380 10.22 BMP7 DLX5 DLX6 IRF6 JAG1 NOTCH1
8 endocrine/exocrine gland MP:0005379 10.21 BMP7 CDH3 EDAR JAG1 NOTCH1 SMARCA4
9 mortality/aging MP:0010768 10.18 BMP7 DLX5 DLX6 EDAR IRF6 JAG1
10 hearing/vestibular/ear MP:0005377 10.08 BMP7 DLX5 DLX6 IRF6 JAG1 NOTCH1
11 limbs/digits/tail MP:0005371 10.03 BMP7 DLX5 DLX6 EDAR IRF6 SMARCA4
12 normal MP:0002873 9.97 BMP7 DLX5 JAG1 NOTCH1 SMARCA4 SNCA
13 pigmentation MP:0001186 9.8 BMP7 EDAR MLANA NOTCH1 SMARCA4 TYR
14 renal/urinary system MP:0005367 9.8 BMP7 JAG1 NOTCH1 SMARCA4 SNCA TP63
15 skeleton MP:0005390 9.73 BMP7 DLX5 DLX6 EDAR IRF6 JAG1
16 respiratory system MP:0005388 9.7 BMP7 DLX5 DLX6 NOTCH1 SMARCA4 TP63
17 vision/eye MP:0005391 9.23 BMP7 EDAR JAG1 NOTCH1 SMARCA4 TP63

Drugs & Therapeutics for Orofacial Cleft 8

Search Clinical Trials , NIH Clinical Center for Orofacial Cleft 8

Genetic Tests for Orofacial Cleft 8

Genetic tests related to Orofacial Cleft 8:

# Genetic test Affiliating Genes
1 Orofacial Cleft 8 29 TP63

Anatomical Context for Orofacial Cleft 8

Publications for Orofacial Cleft 8

Articles related to Orofacial Cleft 8:

# Title Authors PMID Year
1
Whole exome sequencing identifies mutations in 10% of patients with familial non-syndromic cleft lip and/or palate in genes mutated in well-known syndromes. 56 6
29500247 2018
2
A mutation of the p63 gene in non-syndromic cleft lip. 6 56
16740912 2006
3
TP63-Related Disorders 61
20556892 2010

Variations for Orofacial Cleft 8

ClinVar genetic disease variations for Orofacial Cleft 8:

6 (show top 50) (show all 94) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TP63 NM_003722.5(TP63):c.819_820dup (p.Gln274fs)duplication Pathogenic 585267 rs1560277554 3:189584521-189584522 3:189866732-189866733
2 TP63 NM_003722.5(TP63):c.1054A>G (p.Arg352Gly)SNV Pathogenic 6547 rs121908847 3:189586430-189586430 3:189868641-189868641
3 TP63 NM_003722.5(TP63):c.1877T>G (p.Val626Gly)SNV Conflicting interpretations of pathogenicity 901669 3:189612125-189612125 3:189894336-189894336
4 TP63 NM_003722.5(TP63):c.504C>T (p.Asn168=)SNV Conflicting interpretations of pathogenicity 594695 rs141278696 3:189526240-189526240 3:189808451-189808451
5 TP63 NM_003722.5(TP63):c.63-1G>CSNV Conflicting interpretations of pathogenicity 632415 rs200607940 3:189455528-189455528 3:189737739-189737739
6 TP63 NM_003722.5(TP63):c.900G>A (p.Thr300=)SNV Conflicting interpretations of pathogenicity 771580 3:189585639-189585639 3:189867850-189867850
7 TP63 NM_003722.5(TP63):c.84T>G (p.His28Gln)SNV Conflicting interpretations of pathogenicity 725955 3:189455550-189455550 3:189737761-189737761
8 TP63 NM_003722.5(TP63):c.992+9C>TSNV Conflicting interpretations of pathogenicity 729808 3:189585740-189585740 3:189867951-189867951
9 TP63 NM_003722.5(TP63):c.210G>C (p.Gln70His)SNV Conflicting interpretations of pathogenicity 899830 3:189456449-189456449 3:189738660-189738660
10 TP63 NM_003722.5(TP63):c.387G>A (p.Ser129=)SNV Conflicting interpretations of pathogenicity 901000 3:189526123-189526123 3:189808334-189808334
11 TP63 NM_003722.5(TP63):c.688G>C (p.Val230Leu)SNV Conflicting interpretations of pathogenicity 903493 3:189582129-189582129 3:189864340-189864340
12 TP63 NM_003722.5(TP63):c.1404A>G (p.Lys468=)SNV Conflicting interpretations of pathogenicity 901611 3:189604237-189604237 3:189886448-189886448
13 TP63 NM_003722.5(TP63):c.1465G>A (p.Ala489Thr)SNV Conflicting interpretations of pathogenicity 903553 3:189604298-189604298 3:189886509-189886509
14 TP63 NM_003722.5(TP63):c.303G>A (p.Ser101=)SNV Conflicting interpretations of pathogenicity 344380 rs186864205 3:189456542-189456542 3:189738753-189738753
15 TP63 NM_003722.5(TP63):c.699A>G (p.Lys233=)SNV Conflicting interpretations of pathogenicity 344382 rs199727371 3:189582140-189582140 3:189864351-189864351
16 TP63 NM_003722.5(TP63):c.678C>T (p.Arg226=)SNV Conflicting interpretations of pathogenicity 497709 rs61732782 3:189582119-189582119 3:189864330-189864330
17 TP63 NM_003722.5(TP63):c.766+5G>ASNV Conflicting interpretations of pathogenicity 344384 rs374425727 3:189582212-189582212 3:189864423-189864423
18 TP63 NM_003722.5(TP63):c.1374A>G (p.Ser458=)SNV Conflicting interpretations of pathogenicity 344387 rs141794685 3:189604207-189604207 3:189886418-189886418
19 TP63 NM_003722.5(TP63):c.*2426C>TSNV Conflicting interpretations of pathogenicity 344432 rs568346565 3:189614717-189614717 3:189896928-189896928
20 TP63 NM_003722.5(TP63):c.*1939T>GSNV Conflicting interpretations of pathogenicity 344419 rs567626735 3:189614230-189614230 3:189896441-189896441
21 TP63 NM_003722.5(TP63):c.*2205A>GSNV Uncertain significance 344427 rs886058238 3:189614496-189614496 3:189896707-189896707
22 TP63 NM_003722.5(TP63):c.*2273A>GSNV Uncertain significance 344429 rs886058239 3:189614564-189614564 3:189896775-189896775
23 TP63 NM_003722.5(TP63):c.*1846C>TSNV Uncertain significance 344417 rs886058234 3:189614137-189614137 3:189896348-189896348
24 TP63 NM_003722.5(TP63):c.*803G>ASNV Uncertain significance 344404 rs544230654 3:189613094-189613094 3:189895305-189895305
25 TP63 NM_003722.5(TP63):c.*966C>TSNV Uncertain significance 344406 rs539983621 3:189613257-189613257 3:189895468-189895468
26 TP63 NM_003722.5(TP63):c.-65C>TSNV Uncertain significance 344378 rs886058220 3:189349240-189349240 3:189631451-189631451
27 TP63 NM_003722.5(TP63):c.899C>A (p.Thr300Lys)SNV Uncertain significance 344385 rs886058222 3:189585638-189585638 3:189867849-189867849
28 TP63 NM_003722.5(TP63):c.1994T>G (p.Met665Arg)SNV Uncertain significance 344391 rs886058223 3:189612242-189612242 3:189894453-189894453
29 TP63 NM_003722.5(TP63):c.*101C>TSNV Uncertain significance 344392 rs574438859 3:189612392-189612392 3:189894603-189894603
30 TP63 NM_003722.5(TP63):c.*221G>ASNV Uncertain significance 344393 rs886058224 3:189612512-189612512 3:189894723-189894723
31 TP63 NM_003722.5(TP63):c.*382A>GSNV Uncertain significance 344398 rs886058227 3:189612673-189612673 3:189894884-189894884
32 TP63 NM_003722.5(TP63):c.1644C>T (p.Ser548=)SNV Uncertain significance 344388 rs763019843 3:189607265-189607265 3:189889476-189889476
33 TP63 NM_003722.5(TP63):c.*295T>ASNV Uncertain significance 344396 rs886058226 3:189612586-189612586 3:189894797-189894797
34 TP63 NM_003722.5(TP63):c.*2009T>CSNV Uncertain significance 344422 rs886058236 3:189614300-189614300 3:189896511-189896511
35 TP63 NM_003722.5(TP63):c.*1181T>CSNV Uncertain significance 344409 rs565556454 3:189613472-189613472 3:189895683-189895683
36 TP63 NM_003722.5(TP63):c.*1217T>CSNV Uncertain significance 344410 rs886058231 3:189613508-189613508 3:189895719-189895719
37 TP63 NM_003722.5(TP63):c.*1702G>ASNV Uncertain significance 344415 rs886058232 3:189613993-189613993 3:189896204-189896204
38 TP63 NM_003722.5(TP63):c.*2155G>ASNV Uncertain significance 344425 rs573673077 3:189614446-189614446 3:189896657-189896657
39 TP63 NM_003722.5(TP63):c.*1164A>GSNV Uncertain significance 344408 rs886058230 3:189613455-189613455 3:189895666-189895666
40 TP63 NM_003722.5(TP63):c.*1472A>GSNV Uncertain significance 344413 rs375551286 3:189613763-189613763 3:189895974-189895974
41 TP63 NM_003722.5(TP63):c.*1959A>TSNV Uncertain significance 344420 rs527726173 3:189614250-189614250 3:189896461-189896461
42 TP63 NM_003722.5(TP63):c.*232T>CSNV Uncertain significance 344395 rs569527175 3:189612523-189612523 3:189894734-189894734
43 TP63 NM_003722.5(TP63):c.409G>C (p.Asp137His)SNV Uncertain significance 344381 rs762935508 3:189526145-189526145 3:189808356-189808356
44 TP63 NM_003722.5(TP63):c.*2197C>ASNV Uncertain significance 344426 rs886058237 3:189614488-189614488 3:189896699-189896699
45 TP63 NM_003722.5(TP63):c.766+3A>GSNV Uncertain significance 344383 rs886058221 3:189582210-189582210 3:189864421-189864421
46 TP63 NM_003722.5(TP63):c.1523C>T (p.Thr508Ile)SNV Uncertain significance 903554 3:189607144-189607144 3:189889355-189889355
47 TP63 NM_003722.5(TP63):c.1761G>A (p.Leu587=)SNV Uncertain significance 901130 3:189612009-189612009 3:189894220-189894220
48 TP63 NM_003722.5(TP63):c.1834T>G (p.Ser612Ala)SNV Uncertain significance 901668 3:189612082-189612082 3:189894293-189894293
49 TP63 NM_003722.5(TP63):c.-87C>TSNV Uncertain significance 900929 3:189349218-189349218 3:189631429-189631429
50 TP63 NM_003722.5(TP63):c.-38T>CSNV Uncertain significance 902594 3:189349267-189349267 3:189631478-189631478

UniProtKB/Swiss-Prot genetic disease variations for Orofacial Cleft 8:

73
# Symbol AA change Variation ID SNP ID
1 TP63 p.Arg352Gly VAR_035127 rs121908847

Expression for Orofacial Cleft 8

Search GEO for disease gene expression data for Orofacial Cleft 8.

Pathways for Orofacial Cleft 8

GO Terms for Orofacial Cleft 8

Cellular components related to Orofacial Cleft 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.1 TP73 TP63 SMARCA4 IRF6 DLX6 DLX5

Biological processes related to Orofacial Cleft 8 according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.17 TP73 TP63 SMARCA4 NOTCH1 IRF6 DLX6
2 cell differentiation GO:0030154 10.07 TP63 NOTCH1 IRF6 EDAR DLX6 DLX5
3 positive regulation of gene expression GO:0010628 9.98 NOTCH1 EDAR DLX5 CDH3 BMP7
4 positive regulation of apoptotic process GO:0043065 9.97 TP73 SNCA NOTCH1 BMP7
5 multicellular organism development GO:0007275 9.97 TP63 NOTCH1 JAG1 FLG EDAR DLX6
6 positive regulation of transcription, DNA-templated GO:0045893 9.95 TP73 TP63 SMARCA4 NOTCH1 IRF6 DLX5
7 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 TP73 TP63 SMARCA4 NOTCH1 JAG1 IRF6
8 cell cycle arrest GO:0007050 9.84 TP73 NOTCH1 IRF6
9 skeletal system development GO:0001501 9.84 TP63 DLX6 DLX5 BMP7
10 Notch signaling pathway GO:0007219 9.83 TP63 NOTCH1 JAG1
11 epidermis development GO:0008544 9.82 TP63 NOTCH1 EDAR
12 roof of mouth development GO:0060021 9.77 IRF6 DLX6 DLX5
13 epithelial cell differentiation GO:0030855 9.76 TP63 DLX6 DLX5 BMP7
14 positive regulation of epithelial cell proliferation GO:0050679 9.75 NOTCH1 DLX6 DLX5
15 positive regulation of osteoblast differentiation GO:0045669 9.74 TP63 JAG1 BMP7
16 odontogenesis of dentin-containing tooth GO:0042475 9.73 TP63 EDAR BMP7
17 positive regulation of Notch signaling pathway GO:0045747 9.72 TP63 NOTCH1 JAG1
18 neuronal stem cell population maintenance GO:0097150 9.67 NOTCH1 JAG1
19 negative regulation of neuron differentiation GO:0045665 9.67 TP73 NOTCH1 JAG1 BMP7
20 head development GO:0060322 9.66 DLX6 DLX5
21 response to vitamin D GO:0033280 9.65 TYR BMP7
22 embryo development GO:0009790 9.65 DLX6 DLX5
23 protein tetramerization GO:0051262 9.65 TP73 TP63 SNCA
24 negative regulation of stem cell differentiation GO:2000737 9.64 NOTCH1 JAG1
25 pulmonary valve morphogenesis GO:0003184 9.63 NOTCH1 JAG1
26 positive regulation of keratinocyte proliferation GO:0010838 9.63 TP63 CDH3
27 response to muramyl dipeptide GO:0032495 9.62 NOTCH1 JAG1
28 Notch signaling involved in heart development GO:0061314 9.61 NOTCH1 JAG1
29 heart trabecula morphogenesis GO:0061384 9.61 NOTCH1 BMP7
30 cardiac septum morphogenesis GO:0060411 9.61 NOTCH1 JAG1 BMP7
31 pericardium morphogenesis GO:0003344 9.6 NOTCH1 BMP7
32 distal tubule development GO:0072017 9.51 NOTCH1 JAG1
33 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.49 NOTCH1 JAG1
34 anatomical structure formation involved in morphogenesis GO:0048646 9.46 TP63 DLX6 DLX5 BMP7
35 embryonic limb morphogenesis GO:0030326 9.35 TP63 NOTCH1 DLX6 DLX5 BMP7
36 keratinocyte differentiation GO:0030216 9.1 TP63 NOTCH1 LORICRIN JAG1 IRF6 FLG

Molecular functions related to Orofacial Cleft 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.85 SNCA NOTCH1 JAG1 FLG CDH3
2 DNA-binding transcription factor activity GO:0003700 9.85 TP73 TP63 NOTCH1 IRF6 DLX6 DLX5
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.83 TP73 SMARCA4 NOTCH1 DLX6 DLX5
4 sequence-specific DNA binding GO:0043565 9.63 TP73 TP63 NOTCH1 IRF6 DLX6 DLX5
5 p53 binding GO:0002039 9.43 TP73 TP63 SMARCA4
6 structural constituent of epidermis GO:0030280 9.4 LORICRIN FLG
7 transcription regulatory region sequence-specific DNA binding GO:0000976 9.35 TP73 TP63 SNCA IRF6 DLX5
8 MDM2/MDM4 family protein binding GO:0097371 9.32 TP73 TP63
9 transcription regulatory region DNA binding GO:0044212 9.02 TP73 TP63 SNCA IRF6 DLX5

Sources for Orofacial Cleft 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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