Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ORF044
MIFTS: 44

Orofacial Granulomatosis

Categories: Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
Sources

Aliases & Classifications for Orofacial Granulomatosis

About this section

MalaCards integrated aliases for Orofacial Granulomatosis:

Name: Orofacial Granulomatosis 54
Granulomatosis, Orofacial 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 74 C0399496
Sources

Summaries for Orofacial Granulomatosis

About this section
NIH Rare Diseases : 54 Orofacial granulomatosis (OFG) is a condition characterized by granulomatous inflammation of regions of the mouth, jaw and face (maxillofacial), in the absence of a recognised systemic condition known to cause granulomas. Features include lip enlargement, swelling inside and around the mouth, oral ulcerations (sores), and inflammation of the gums (gingivitis). There may be only swelling inside the mouth or permanent disfiguring swelling of the lips and face.  OFG includes granulomatous cheilitis (when it presents as a persistent or recurrent lip swelling), and Melkersson-Rosenthal syndrome  (which includes CG, facial nerve palsy and fissured tongue) that can manifest with only CG. In some cases, orofacial granulomatosis is part of another disease such as Crohn's disease, sarcoidosis, and infectious diseases such as tuberculosis.  The diagnosis of OFG is confirmed only by biopsy and microscopic tissue analysis identifying the noncaseating granulomas.  When OFG occurs alone, without other associated diseases it is considered idiopathic. Up to 40% of the people with orofacial granulomatosis (OFG) may have positive reactions to patch allergy tests. The exact prevalence of  idiopathic OFG is not known, but it is considered a rare condition in most literature reports.   Treatment is difficult and has to be individualized, but may include corticosteroids (systemic or injected inside the lesions), and other medication.  Granulomatous cheilitis or OFG may improve with a cinnamon- and benzoate-free diet.  Response to treatment is slow, and can take years, but most people improve. Surgery may be required for severe permanent swelling interfering with speaking or eating.

MalaCards based summary : Orofacial Granulomatosis, also known as granulomatosis, orofacial, is related to crohn's disease and folliculitis, and has symptoms including muscle weakness, polydipsia and oral manifestations. An important gene associated with Orofacial Granulomatosis is CCR3 (C-C Motif Chemokine Receptor 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include testes, tongue and b cells, and related phenotypes are cellular and hematopoietic system

Wikipedia : 77 Orofacial granulomatosis (OFG) is a condition characterized by persistent enlargement of the soft... more...

Sources

Related Diseases for Orofacial Granulomatosis

About this section

Diseases related to Orofacial Granulomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 30.8 IL10 NOD2 TNF
2 folliculitis 30.0 CCL5 IFNG IL4
3 food allergy 29.7 FLG IFNG IL10 IL4
4 erythema multiforme 29.6 CXCR3 IFNG TNF
5 allergic hypersensitivity disease 29.5 CCL5 CCR3 IFNG IL10 IL4
6 tonsillitis 29.3 CD79A IFNG IL4 TNF
7 leishmaniasis 29.2 IFNG IL10 IL4 TNF
8 periodontitis 29.2 IFNG IL10 IL4 TNF
9 inflammatory bowel disease 29.1 IFNG IL10 IL4 NOD2 TNF
10 testicular leukemia 10.5 CCR3 CD79A
11 vulvovaginitis 10.4 CCL5 IL10
12 african tick-bite fever 10.4 CCL5 IFNG
13 strongyloidiasis 10.4 CD79A IFNG
14 cephalosporin allergy 10.4 IFNG IL10
15 congenital hypogammaglobulinemia 10.3 CD79A IL4
16 pouchitis 10.3 IL10 NOD2
17 chromoblastomycosis 10.3 CXCR3 IL4
18 folliculotropic mycosis fungoides 10.3 CCR3 CXCR3
19 retinitis pigmentosa 22 10.3 IL10 IL4
20 apple allergy 10.3 IL10 IL4
21 beta-lactam allergy 10.3 IL10 IL4
22 respiratory syncytial virus infectious disease 10.3 CCL3 CCL5
23 b-cell growth factor 10.3 IFNG IL4
24 penicillin allergy 10.3 IFNG IL4
25 crustacean allergy 10.3 IFNG IL4
26 atopic keratoconjunctivitis 10.3 IFNG IL4
27 inflammatory bowel disease 4 10.3 IL4 NOD2
28 palladium allergic contact dermatitis 10.3 CCL3 IL10
29 necatoriasis 10.3 CCL3 IL10
30 variola major 10.3 CCL3 IFNG
31 exercise-induced anaphylaxis 10.2 CD79A FLG
32 melkersson-rosenthal syndrome 10.2
33 oral lichen planus 10.2 CCL5 CCR5 CXCR3
34 ocular toxoplasmosis 10.2 CCR5 CD79A NOD2
35 aids dementia complex 10.2 CCR3 TNF
36 kimura disease 10.2 CCL5 CCR3 IL4
37 sporotrichosis 10.2 CD79A IFNG IL10
38 peanut allergy 10.2 FLG IFNG IL10
39 whiplash 10.1 CCL3 CCL5 CCR5
40 hashimoto thyroiditis 10.1 CXCR3 IFNG IL4
41 chronic nk-cell lymphocytosis 10.1 CCL3 CCL5 CCR5
42 choroiditis 10.1 IL10 TNF
43 trichuriasis 10.1 IL10 TNF
44 allergic rhinitis 10.1 IFNG IL10 IL4
45 transient hypogammaglobulinemia 10.1 IL10 TNF
46 vernal keratoconjunctivitis 10.1 CCL5 CXCR3 IL4
47 idiopathic achalasia 10.1 IL10 TNF
48 multifocal choroiditis 10.1 IL10 TNF
49 yellow fever 10.1 CCL5 CCR5 IL4
50 milk allergy 10.1 CD79A IL10 IL4

Graphical network of the top 20 diseases related to Orofacial Granulomatosis:



Diseases related to Orofacial Granulomatosis
Sources

Symptoms & Phenotypes for Orofacial Granulomatosis

About this section

UMLS symptoms related to Orofacial Granulomatosis:


muscle weakness, polydipsia, oral manifestations

MGI Mouse Phenotypes related to Orofacial Granulomatosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 CCR3 CCR5 CD79A CXCR3 F2R F2RL1
2 hematopoietic system MP:0005397 10.18 CCL5 CCR3 CCR5 CD79A CXCR3 F2R
3 homeostasis/metabolism MP:0005376 10.11 CCR3 CCR5 CD79A CXCR3 F2R F2RL1
4 immune system MP:0005387 10.1 CCL5 CCR3 CCR5 CD79A CXCR3 F2R
5 digestive/alimentary MP:0005381 9.98 CCR5 F2R IFNG IL10 IL4 NOD2
6 liver/biliary system MP:0005370 9.86 CCR5 CD79A F2R F2RL1 IFNG IL10
7 neoplasm MP:0002006 9.76 CCR5 CD79A CXCR3 F2R F2RL1 IFNG
8 no phenotypic analysis MP:0003012 9.5 CD79A F2R F2RL1 IFNG IL10 IL4
9 renal/urinary system MP:0005367 9.1 CD79A CXCR3 F2R F2RL1 IFNG IL4
Sources

Drugs & Therapeutics for Orofacial Granulomatosis

About this section

Search Clinical Trials , NIH Clinical Center for Orofacial Granulomatosis

Sources

Genetic Tests for Orofacial Granulomatosis

About this section
Sources

Anatomical Context for Orofacial Granulomatosis

About this section

MalaCards organs/tissues related to Orofacial Granulomatosis:

42
Testes, Tongue, B Cells, Tonsil, T Cells, Lymph Node, Eye
Sources

Publications for Orofacial Granulomatosis

About this section

Articles related to Orofacial Granulomatosis:

(show top 50) (show all 152)
# Title Authors Year
1
Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn's Disease? ( 30796823 )
2019
2
The mouth in inflammatory bowel disease and aspects of orofacial granulomatosis. ( 31090144 )
2019
3
Contact granulomatous hypersensitivity to indium in a patient with orofacial granulomatosis. ( 30957231 )
2019
4
Low-level laser as a complementary therapy in orofacial granulomatosis management: a case report. ( 30987889 )
2019
5
A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome. ( 29766816 )
2018
6
Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease. ( 30024055 )
2018
7
Folliculitis decalvans and orofacial granulomatosis. ( 30008653 )
2018
8
Orofacial granulomatosis: an unsuccessful response to weekly azithromycin pulse therapy. ( 29477603 )
2018
9
Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases. ( 29641703 )
2018
10
STAT3-Deficient hyperimmunoglobulin E syndrome: report of a case with orofacial granulomatosis-like disease. ( 30126807 )
2018
11
Diagnosis and Treatment of Orofacial Granulomatosis. ( 30345959 )
2018
12
Clinicopathological diagnosis of orofacial granulomatosis. ( 28217469 )
2017
13
Detailed Follow-up Study of Pediatric Orofacial Granulomatosis Patients. ( 28425922 )
2017
14
Effectiveness of surgical treatment of severe macrocheilia in a patient with orofacial granulomatosis. ( 28748609 )
2017
15
Orofacial granulomatosis in a 12-year-old girl successfully treated with intravenous pulse corticosteroid therapy and chloroquine. ( 28940800 )
2017
16
Orofacial granulomatosis: A case report of three cases may be caused by apical periodontitis. ( 28953630 )
2017
17
Treatment of orofacial granulomatosis: a case report. ( 29065902 )
2017
18
Orofacial granulomatosis: A disease or a concealed warning.?? ( 29323072 )
2017
19
Orofacial granulomatosis as early manifestation of Crohn's disease: report of a case in a paediatric patient. ( 28045322 )
2016
20
Crohn's Disease with Orofacial Granulomatosis Is a Distinct Disease Subtype, or Is It? ( 27271492 )
2016
21
Does Crohn's Disease with Concomitant Orofacial Granulomatosis Represent a Distinctive Disease Subtype? ( 26829409 )
2016
22
Azathioprine is effective for oral involvement in Crohn's disease but not for orofacial granulomatosis alone. ( 26593695 )
2016
23
Uncommon inflammatory swelling of the lips: orofacial granulomatosis. ( 26759437 )
2016
24
Histopathological Features of Orofacial Granulomatosis. ( 26894770 )
2016
25
HLA-B*44 May Be a Marker for Orofacial Granulomatosis. ( 27280749 )
2016
26
Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis. ( 27306066 )
2016
27
Orofacial granulomatosis. ( 27343966 )
2016
28
The role of exclusive enteral nutrition in the management of orofacial granulomatosis in children. ( 27457793 )
2016
29
Update on Orofacial Granulomatosis. ( 29029658 )
2016
30
Orofacial granulomatosis: do not forget leishmaniasis. ( 26336193 )
2015
31
Orofacial granulomatosis responding to weekly azithromycin pulse therapy. ( 25494221 )
2015
32
Orofacial granulomatosis as a presenting feature of Crohn's disease. ( 25576503 )
2015
33
Orofacial granulomatosis: clinical signs of different pathologies. ( 25592641 )
2015
34
Orofacial granulomatosis in children: think about Crohn's disease. ( 25618553 )
2015
35
Orofacial granulomatosis affecting lip and gingiva in a 15-year-old patient: A rare case report. ( 25821385 )
2015
36
Orofacial Granulomatosis. ( 26143423 )
2015
37
Orofacial Granulomatosis. ( 26470520 )
2015
38
OROFACIAL GRANULOMATOSIS: CASE REPORT. ( 26666112 )
2015
39
A rare case of primary orofacial granulomatosis of gingiva during pregnancy. ( 26980981 )
2015
40
Characterisation of a Swedish cohort with orofacial granulomatosis with or without Crohn's disease. ( 24645728 )
2015
41
Adverse reaction to silicone simulating orofacial granulomatosis. ( 24750369 )
2015
42
Idiopathic orofacial granulomatosis - a diagnostic and treatment challenge. ( 25584331 )
2014
43
Long-term effectiveness of intralesional triamcinolone acetonide therapy in orofacial granulomatosis: an observational cohort study. ( 24088036 )
2014
44
Thalidomide in the treatment of refractory orofacial granulomatosis. ( 24601875 )
2014
45
Unifocal orofacial granulomatosis in retromolar mucosa: surgical treatment with Er,Cr:YSGG laser. ( 24790722 )
2014
46
Orofacial granulomatosis successfully treated with mycophenolate mofetil. ( 24831337 )
2014
47
A case series of patients diagnosed with orofacial granulomatosis presenting primarily with dense infiltrates and severe periorbital edema. ( 24836447 )
2014
48
Association between orofacial granulomatosis and Crohn's disease in children: systematic review. ( 24966621 )
2014
49
Oral medicine case book 57: orofacial granulomatosis. ( 24974521 )
2014
50
Vestibular hyperplastic folds. Orofacial granulomatosis. ( 24983176 )
2014
Sources

Variations for Orofacial Granulomatosis

About this section
Sources

Expression for Orofacial Granulomatosis

About this section
Search GEO for disease gene expression data for Orofacial Granulomatosis.
Sources

Pathways for Orofacial Granulomatosis

About this section

Pathways related to Orofacial Granulomatosis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.94 BTNL2 CCL3 CCL5 CCR5 CD79A IFNG
2
PEDF Induced Signaling 65
Show member pathways
 13.59 CCL3 CCL5 CCR3 CCR5 CXCR3 IFNG
3
TGF-Beta Pathway 65
Show member pathways
 13.46 CCL3 CCL5 F2R IFNG IL10 IL4
4
Akt Signaling 65
Show member pathways
 13.31 CCL3 CCL5 CCR3 CCR5 CXCR3 IL10
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.24 CCL3 CCL5 CCR5 IFNG IL10 IL4
6
PAK Pathway 65
Show member pathways
 13.18 CCL3 CCL5 CCR3 CCR5 CXCR3 IL10
7
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.04 CCL3 CCL5 IFNG IL10 NOD2 TNF
8
Human cytomegalovirus infection 38
Show member pathways
 12.89 CCL3 CCL5 CCR3 CCR5 TNF
9
CCR5 Pathway in Macrophages 65
Show member pathways
 12.82 CCL3 CCL5 CCR3 CCR5 CXCR3
10
Immune response NFAT in immune response 23
Show member pathways
 12.58 CD79A IFNG IL10 IL4 TNF
11
Th17 cell differentiation 38
Show member pathways
 12.55 IFNG IL10 IL4 NOD2 TNF
12
T cell receptor signaling pathway 38
Show member pathways
 12.48 CCR5 IFNG IL10 IL4 TNF
13
NF-kappaB Signaling 4
12.45 CCL5 CD79A IFNG IL10 IL4 TNF
14
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.34 CCR5 IFNG IL10 IL4
15
Selenium Micronutrient Network 1
Show member pathways
 12.28 CCL5 IFNG IL4 TNF
16
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.2 IFNG IL10 IL4 TNF
17
Tuberculosis 38
12.19 IFNG IL10 NOD2 TNF
18
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.16 CCL3 CCL5 CCR3 CCR5 CXCR3 F2R
19
Toxoplasmosis 38
Show member pathways
 12.16 CCR5 IFNG IL10 IL4 TNF
20
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.03 CCL3 CCL5 IFNG IL10 IL4
21
Th1 Differentiation Pathway 66
Show member pathways
 11.99 IFNG IL10 TNF
22
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.97 IFNG IL4 TNF
23
Spinal Cord Injury 1
11.95 IFNG IL4 TNF
24
IL12-mediated signaling events 1
Show member pathways
 11.95 CCL3 CCR5 IFNG IL4
25
Interleukin-4 and 13 signaling 67
11.92 IL10 IL4 TNF
26
TNF signaling pathway 38
11.9 CCL5 NOD2 TNF
27
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 11.9 CCL3 CCL5 CCR3 CCR5 CXCR3
28
GPCRs, Other 1
11.86 CCR5 CXCR3 F2R
29
Amoebiasis 38
11.83 IFNG IL10 TNF
30
Jak-Stat Signaling Pathway (sino) 68
11.82 CCR5 IFNG IL10
31
Rheumatoid arthritis 38
11.8 CCL3 CCL5 IFNG TNF
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.8 CCR3 CD79A IFNG IL10 IL4 TNF
33
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 IFNG IL4 TNF
34
Dendritic Cells Developmental Lineage Pathway 66
11.7 IFNG IL10 TNF
35
Innate Lymphoid Cell Differentiation Pathways 66
11.54 CCL3 CXCR3 IFNG IL10 IL4 TNF
36
Lung fibrosis 1
11.52 CCL3 CCL5 CCR3 IL4 TNF
37
Malaria 38
11.51 IFNG IL10 TNF
38
Th2 Differentiation Pathway 66
11.47 IFNG IL10 IL4
39
Development and heterogeneity of the ILC family 1
11.29 IFNG IL4 TNF
40
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.28 CCL3 CCL5 IFNG IL10 IL4 TNF
41
African trypanosomiasis 38
11.27 F2RL1 IFNG IL10 TNF
42
OX40 Pathway 65
11.17 IFNG IL10 IL4
43
IL1 and megakaryocytes in obesity 1
11.14 CCR3 F2R IFNG
44
Cytokines and Inflammatory Response 1
11.13 IFNG IL10 IL4 TNF
45
G-protein signaling_RhoB regulation pathway 23
11.11 CCL3 CCL5 IL10 IL4 TNF
46
G-protein signaling_Rap2B regulation pathway 23
10.96 CCL3 CCL5 IL10 IL4 TNF
47
LDL Oxidation in Atherogenesis 65
10.89 CCL3 TNF
48
Interleukin-10 signaling 67
10.79 CCL3 CCL5 CCR5 IL10 IL4 TNF
Sources

GO Terms for Orofacial Granulomatosis

About this section

Cellular components related to Orofacial Granulomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CCR5 CXCR3 F2R NOD2 TNF
2 external side of plasma membrane GO:0009897 9.1 BTNL2 CCR3 CCR5 CD79A CXCR3 TNF

Biological processes related to Orofacial Granulomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CCL3 CCL5 IFNG IL10 IL4 TNF
2 cell surface receptor signaling pathway GO:0007166 9.98 CCR5 CD79A CXCR3 IFNG
3 positive regulation of cell migration GO:0030335 9.96 CCL3 CCL5 F2R F2RL1
4 MAPK cascade GO:0000165 9.94 CCL3 CCL5 CCR5 TNF
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 F2R F2RL1 NOD2 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.91 CCR5 IL10 NOD2 TNF
7 response to virus GO:0009615 9.88 CCL5 IFNG TNF
8 cytokine-mediated signaling pathway GO:0019221 9.88 CCL3 CCL5 CCR5 IL10 IL4 TNF
9 positive regulation of JNK cascade GO:0046330 9.86 F2RL1 NOD2 TNF
10 B cell differentiation GO:0030183 9.85 CD79A IL10 IL4
11 chemotaxis GO:0006935 9.85 CCL3 CCL5 CCR3 CCR5 CXCR3
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 CCL5 IFNG IL4
13 regulation of insulin secretion GO:0050796 9.83 CCL5 IFNG TNF
14 calcium-mediated signaling GO:0019722 9.83 CCL3 CCR3 CCR5 CXCR3
15 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 CCR3 CCR5 CXCR3 F2R F2RL1
16 positive regulation of T cell proliferation GO:0042102 9.81 BTNL2 CCL5 IL4
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 CCL5 F2R F2RL1 TNF
18 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 CCL3 CCL5 F2R F2RL1 NOD2 TNF
19 cellular response to organic cyclic compound GO:0071407 9.78 CCL3 CCL5 NOD2 TNF
20 protein kinase B signaling GO:0043491 9.77 CCL3 CCL5 TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 CCL3 CCL5 TNF
22 regulation of sensory perception of pain GO:0051930 9.73 CCL3 F2R IL10
23 positive regulation of osteoclast differentiation GO:0045672 9.72 IFNG TNF
24 dendritic cell chemotaxis GO:0002407 9.72 CCL5 CCR5
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 F2RL1 TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.71 IL10 TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 TNF
29 positive regulation of interleukin-8 secretion GO:2000484 9.71 F2R F2RL1
30 positive regulation of calcium ion transport GO:0051928 9.71 CCL3 CCL5 F2R
31 macrophage chemotaxis GO:0048246 9.7 CCL3 CCL5
32 regulation of blood coagulation GO:0030193 9.7 F2R F2RL1
33 negative regulation by host of viral transcription GO:0043922 9.7 CCL3 CCL5
34 T cell chemotaxis GO:0010818 9.69 CCL3 CXCR3
35 neutrophil activation GO:0042119 9.69 CCL5 F2RL1
36 response to cholesterol GO:0070723 9.69 CCL3 CCR5
37 signaling GO:0023052 9.68 CCL3 CCR5
38 thrombin-activated receptor signaling pathway GO:0070493 9.68 F2R F2RL1
39 cell-cell junction maintenance GO:0045217 9.67 F2R F2RL1
40 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IL4
42 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.65 CCL3 CCR5
43 cell chemotaxis GO:0060326 9.65 CCL3 CCL5 CCR3 CCR5 CXCR3
44 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
45 positive regulation of natural killer cell chemotaxis GO:2000503 9.63 CCL3 CCL5
46 regulation of isotype switching GO:0045191 9.62 IL10 IL4
47 type 2 immune response GO:0042092 9.61 IL10 IL4
48 immune response GO:0006955 9.61 CCL3 CCL5 CCR3 CCR5 CXCR3 IFNG
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG TNF
50 receptor biosynthetic process GO:0032800 9.58 IL10 TNF

Molecular functions related to Orofacial Granulomatosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.89 CCR3 CCR5 CXCR3 F2R F2RL1
2 G-protein alpha-subunit binding GO:0001965 9.51 F2R F2RL1
3 chemokine binding GO:0019956 9.5 CCR3 CCR5 CXCR3
4 G-protein beta-subunit binding GO:0031681 9.48 F2R F2RL1
5 CCR5 chemokine receptor binding GO:0031730 9.46 CCL3 CCL5
6 phospholipase activator activity GO:0016004 9.43 CCL3 CCL5
7 C-C chemokine binding GO:0019957 9.43 CCR3 CCR5 CXCR3
8 CCR1 chemokine receptor binding GO:0031726 9.4 CCL3 CCL5
9 thrombin-activated receptor activity GO:0015057 9.37 F2R F2RL1
10 C-C chemokine receptor activity GO:0016493 9.33 CCR3 CCR5 CXCR3
11 chemokine receptor activity GO:0004950 9.13 CCR3 CCR5 CXCR3
12 cytokine activity GO:0005125 9.1 CCL3 CCL5 IFNG IL10 IL4 TNF
Sources

Sources for Orofacial Granulomatosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....