MCID: ORP002
MIFTS: 24

Oropouche Fever

Categories: Infectious diseases

Aliases & Classifications for Oropouche Fever

MalaCards integrated aliases for Oropouche Fever:

Name: Oropouche Fever 12 15
Oropouche Virus Disease 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:0050521
ICD10 32 A93.0
UMLS 70 C0276386

Summaries for Oropouche Fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Oropouche virus, which is transmitted by biting midge, Culicoides paraensis. The infection has symptom fever, has symptom chills, has symptom headache, has symptom anorexia, has symptom muscle pain, has symptom joint pain, and has symptom vomiting.

MalaCards based summary : Oropouche Fever, also known as oropouche virus disease, is related to aseptic meningitis and ifap syndrome 2. An important gene associated with Oropouche Fever is MIR26A1 (MicroRNA 26a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

Wikipedia : 73 Oropouche fever is a tropical viral infection transmitted by biting midges and mosquitoes from the blood... more...

Related Diseases for Oropouche Fever

Diseases related to Oropouche Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 10.2
2 ifap syndrome 2 10.0
3 chikungunya 10.0
4 disease by infectious agent 10.0
5 venezuelan hemorrhagic fever 10.0
6 exanthem 10.0
7 dengue disease 10.0
8 yellow fever 10.0
9 microsporidiosis 9.9 HSFX2 HSFX1
10 sting-associated vasculopathy with onset in infancy 9.8 MAVS IRF3
11 noonan syndrome 4 9.8 MAVS IRF3
12 chilblain lupus 1 9.8 MAVS IRF3
13 lymphocytic choriomeningitis 9.8 MAVS IRF3
14 microphthalmia with limb anomalies 9.7 MAVS IRF3
15 newcastle disease 9.7 MAVS IRF3
16 japanese encephalitis 9.6 MAVS IRF3

Graphical network of the top 20 diseases related to Oropouche Fever:



Diseases related to Oropouche Fever

Symptoms & Phenotypes for Oropouche Fever

Drugs & Therapeutics for Oropouche Fever

Search Clinical Trials , NIH Clinical Center for Oropouche Fever

Genetic Tests for Oropouche Fever

Anatomical Context for Oropouche Fever

Publications for Oropouche Fever

Articles related to Oropouche Fever:

(show all 26)
# Title Authors PMID Year
1
Nocturnal Mosquitoes of Pará State in the Brazilian Amazon: Species Composition, Habitat Segregation, and Seasonal Variation. 61
32484514 2020
2
Oropouche Virus Detection in Febrile Patients' Saliva and Urine Samples in Salvador, Bahia, Brazil. 61
31787741 2020
3
Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing. 61
31961856 2020
4
Oropouche virus detection in saliva and urine. 61
32130368 2020
5
First outbreak of Oropouche Fever reported in a non-endemic western region of the Peruvian Amazon: Molecular diagnosis and clinical characteristics. 61
30991139 2019
6
Culicoides Biting Midges-Underestimated Vectors for Arboviruses of Public Health and Veterinary Importance. 61
31022868 2019
7
Oropouche Virus-Associated Aseptic Meningoencephalitis, Southeastern Brazil. 61
30666950 2019
8
Oropouche Fever: A Review. 61
29617280 2018
9
Oropouche fever, an emergent disease from the Americas. 61
29247710 2018
10
Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus. 61
30402510 2018
11
Vegetation loss and the 2016 Oropouche fever outbreak in Peru. 61
28327792 2017
12
[ZOOPATHOGENIC ORTHOBUNIAVIRUSES (ORTHOBUNYAVIRUS, BUNYAVIRIDAE)]. 61
27451495 2016
13
Genetic analysis of members of the species Oropouche virus and identification of a novel M segment sequence. 61
25735305 2015
14
Spread of Oropouche virus into the central nervous system in mouse. 61
25310583 2014
15
Experimental infection of suckling mice by subcutaneous inoculation with Oropouche virus. 61
22877689 2012
16
Identification of Oropouche Orthobunyavirus in the cerebrospinal fluid of three patients in the Amazonas, Brazil. 61
22492162 2012
17
Atypical lymphocytosis in leptospirosis: a cohort of hospitalized cases between 1996 and 2009 in State of Rio de Janeiro, Brazil. 61
21860995 2011
18
Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. 61
21949892 2011
19
Molecular epidemiology of Oropouche virus, Brazil. 61
21529387 2011
20
Oropouche fever outbreak, Manaus, Brazil, 2007-2008. 61
19961705 2009
21
Oropouche fever epidemic in Northern Brazil: epidemiology and molecular characterization of isolates. 61
19117799 2009
22
Reemergence of Oropouche fever, northern Brazil. 61
17553235 2007
23
Diagnosis of Oropouche virus infection by RT-nested-PCR. 61
11748670 2002
24
The emerging epidemiology of Venezuelan hemorrhagic fever and Oropouche fever in tropical South America. 61
7840443 1994
25
Epidemic Oropouche virus disease in northern Brazil. 61
7326505 1981
26
Oropouche virus. II. Epidemiological observations during an epidemic in Santarém, Pará, Brazil in 1975. 61
7212162 1981

Variations for Oropouche Fever

Expression for Oropouche Fever

Search GEO for disease gene expression data for Oropouche Fever.

Pathways for Oropouche Fever

Pathways related to Oropouche Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 MIR26A2 MIR26A1 MIR19B1
2 10.72 MIR26A2 MIR26A1 MIR19B1
3
Show member pathways
10.32 MAVS IRF3

GO Terms for Oropouche Fever

Cellular components related to Oropouche Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.8 MIR26A2 MIR26A1 MIR19B1

Biological processes related to Oropouche Fever according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of DNA-binding transcription factor activity GO:0043433 9.63 MIR26A2 MIR26A1
2 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.63 MIR26A2 MIR26A1
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.62 MIR26A2 MIR26A1
4 negative regulation of BMP signaling pathway GO:0030514 9.62 MIR26A2 MIR26A1
5 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.61 MIR26A2 MIR26A1
6 positive regulation of interferon-beta production GO:0032728 9.61 MAVS IRF3
7 negative regulation of type I interferon production GO:0032480 9.6 MAVS IRF3
8 negative regulation of MAPK cascade GO:0043409 9.59 MIR26A2 MIR26A1
9 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.58 MIR26A2 MIR26A1
10 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.58 MIR26A2 MIR26A1
11 negative regulation of interleukin-17 production GO:0032700 9.57 MIR26A2 MIR26A1
12 positive regulation of interferon-alpha production GO:0032727 9.56 MAVS IRF3
13 cellular response to exogenous dsRNA GO:0071360 9.55 MAVS IRF3
14 vascular endothelial growth factor signaling pathway GO:0038084 9.54 MIR26A2 MIR26A1
15 negative regulation of nitric-oxide synthase activity GO:0051001 9.52 MIR26A2 MIR26A1
16 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.51 MIR26A2 MIR26A1
17 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.49 MAVS IRF3
18 negative regulation of neuroinflammatory response GO:0150079 9.48 MIR26A2 MIR26A1
19 negative regulation of heart rate GO:0010459 9.46 MIR26A2 MIR26A1
20 negative regulation of cell cycle G1/S phase transition GO:1902807 9.43 MIR26A2 MIR26A1
21 negative regulation of interleukin-6 production GO:0032715 9.43 MIR26A2 MIR26A1 MIR19B1
22 negative regulation of vascular smooth muscle cell differentiation GO:1905064 9.4 MIR26A2 MIR26A1
23 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.37 MIR26A2 MIR26A1
24 central nervous system myelin maintenance GO:0032286 9.32 MIR26A2 MIR26A1
25 negative regulation of inward rectifier potassium channel activity GO:1903609 9.16 MIR26A2 MIR26A1
26 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.13 MIR26A2 MIR26A1 MIR19B1
27 negative regulation of cholesterol efflux GO:0090370 8.8 MIR26A2 MIR26A1 MIR19B1

Molecular functions related to Oropouche Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 IRF3 HSFX2 HSFX1
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.8 MIR26A2 MIR26A1 MIR19B1

Sources for Oropouche Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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