OHDS
MCID: ORT010
MIFTS: 17

Orthostatic Hypotensive Disorder, Streeten Type (OHDS)

Aliases & Classifications for Orthostatic Hypotensive Disorder, Streeten Type

MalaCards integrated aliases for Orthostatic Hypotensive Disorder, Streeten Type:

Name: Orthostatic Hypotensive Disorder, Streeten Type 57 70
Orthostatic Hypotensive Disorder of Streeten 57 13
Orthostatic Hypotensive Disorder 57
Hyperbradykininism 57
Ohds 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
orthostatic hypotensive disorder, streeten type:
Inheritance autosomal dominant inheritance


Summaries for Orthostatic Hypotensive Disorder, Streeten Type

MalaCards based summary : Orthostatic Hypotensive Disorder, Streeten Type, also known as orthostatic hypotensive disorder of streeten, is related to syncope, familial vasovagal and syncope. An important gene associated with Orthostatic Hypotensive Disorder, Streeten Type is OHDS (Orthostatic Hypotensive Disorder Of Streeten). The drugs Ergocalciferol and Vitamin D2 have been mentioned in the context of this disorder. Related phenotypes are bruising susceptibility and syncope

More information from OMIM: 143850

Related Diseases for Orthostatic Hypotensive Disorder, Streeten Type

Diseases related to Orthostatic Hypotensive Disorder, Streeten Type via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 3, show less)
# Related Disease Score Top Affiliating Genes
1 syncope, familial vasovagal 11.2
2 syncope 10.0
3 pure autonomic failure 10.0

Symptoms & Phenotypes for Orthostatic Hypotensive Disorder, Streeten Type

Human phenotypes related to Orthostatic Hypotensive Disorder, Streeten Type:

31 (showing 4, show less)
# Description HPO Frequency HPO Source Accession
1 bruising susceptibility 31 HP:0000978
2 syncope 31 HP:0001279
3 orthostatic hypotension 31 HP:0001278
4 facial erythema 31 HP:0001041

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neuro:
syncope

Skin:
facial erythema
ecchymoses, and purple leg discoloration after standing

Cardiac:
orthostatic hypotension

Lab:
hyperbradykininism

Clinical features from OMIM®:

143850 (Updated 20-May-2021)

Drugs & Therapeutics for Orthostatic Hypotensive Disorder, Streeten Type

Drugs for Orthostatic Hypotensive Disorder, Streeten Type (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 4, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
2 Vitamin D2 Phase 4
3 Ergocalciferols Phase 4
4 Pharmaceutical Solutions Phase 3

Interventional clinical trials:

(showing 4, show less)
# Name Status NCT ID Phase Drugs
1 Response of Secondary Hyperparathyroidism to Paricalcitol Versus Ergocalciferol in Patients With Stage 3 and 4 Chronic Kidney Disease With Vitamin D Deficiency: a Randomized Controlled Trial Completed NCT00958451 Phase 4 Paricalcitol;Ergocalciferol
2 Randomized Phase III Trial Comparing Conventional Vitamin D Supplementation vs. Vitamin D Supplementation Tailored to Vitamin D Deficiency in Breast Cancer Patients Treated by Neoadjuvant or Adjuvant Chemotherapy. Completed NCT01480869 Phase 3 calcium and cholecalciferol;calcium and cholecalciferol
3 Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures. Withdrawn NCT02138591 Phase 3
4 Early Effect of Vitamin D in Primary Hyperparathyroidism Withdrawn NCT01329666 Phase 2, Phase 3

Search NIH Clinical Center for Orthostatic Hypotensive Disorder, Streeten Type

Genetic Tests for Orthostatic Hypotensive Disorder, Streeten Type

Anatomical Context for Orthostatic Hypotensive Disorder, Streeten Type

Publications for Orthostatic Hypotensive Disorder, Streeten Type

Articles related to Orthostatic Hypotensive Disorder, Streeten Type:

(showing 4, show less)
# Title Authors PMID Year
1
Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q. 57 61
9792870 1998
2
Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. 57
11590132 2001
3
Hyperbradykininism: a new orthostatic syndrome. 57
4117376 1972
4
NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene. 61
11840194 2001

Variations for Orthostatic Hypotensive Disorder, Streeten Type

Expression for Orthostatic Hypotensive Disorder, Streeten Type

Search GEO for disease gene expression data for Orthostatic Hypotensive Disorder, Streeten Type.

Pathways for Orthostatic Hypotensive Disorder, Streeten Type

GO Terms for Orthostatic Hypotensive Disorder, Streeten Type

Sources for Orthostatic Hypotensive Disorder, Streeten Type

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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