MCID: ORT001
MIFTS: 28

Orthostatic Proteinuria

Categories: Nephrological diseases

Aliases & Classifications for Orthostatic Proteinuria

MalaCards integrated aliases for Orthostatic Proteinuria:

Name: Orthostatic Proteinuria 12 15 73
Postural Albuminuria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9617
ICD10 33 R80.2
ICD9CM 35 593.6
UMLS 73 C0232867

Summaries for Orthostatic Proteinuria

MalaCards based summary : Orthostatic Proteinuria, also known as postural albuminuria, is related to renal nutcracker syndrome and pyuria. An important gene associated with Orthostatic Proteinuria is MN1 (MN1 Proto-Oncogene, Transcriptional Regulator), and among its related pathways/superpathways is Renin secretion. Affiliated tissues include kidney and heart, and related phenotype is growth/size/body region.

Related Diseases for Orthostatic Proteinuria

Diseases related to Orthostatic Proteinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 renal nutcracker syndrome 11.2
2 pyuria 10.2 ALB MN1
3 ascending cholangitis 10.2 ALB C3
4 benign essential hypertension 10.1 ALB REN
5 kidney papillary necrosis 10.1 ALB REN
6 membranoproliferative glomerulonephritis 10.1 ALB C3
7 henoch-schoenlein purpura 10.1 C3 HSP90AA1
8 arteriolosclerosis 10.1 C3 REN
9 hepatic vascular disease 10.1 ALB REN
10 hypertensive nephropathy 10.1 ACE ALB
11 syndrome of inappropriate antidiuretic hormone 10.1 ACE ALB
12 microvascular complications of diabetes 3 10.1 ACE ALB
13 ovarian hyperstimulation syndrome 10.1 ALB REN
14 hyporeninemic hypoaldosteronism 10.0 ACE REN
15 hypoaldosteronism 10.0 ACE REN
16 uveoparotid fever 10.0 ACE ENSG00000264813
17 renal artery obstruction 10.0 ACE REN
18 autoimmune atherosclerosis 10.0 ACE ENSG00000264813
19 hypertension, diastolic 10.0 ACE REN
20 intermittent claudication 10.0 ACE ALB
21 obstructive jaundice 10.0 ALB REN
22 fiedler's myocarditis 10.0 ACE ENSG00000264813
23 hypertensive encephalopathy 10.0 ACE REN
24 hypertensive retinopathy 10.0 ACE REN
25 renal artery disease 10.0 ACE REN
26 pyelonephritis 10.0 ACE ALB
27 immunodeficiency 43 10.0 ALB B2M
28 malignant hypertension 10.0 ACE REN
29 subdural empyema 10.0 ACE ENSG00000264813
30 hypersensitivity reaction type iii disease 10.0 ALB C3 HSP90AA1
31 fibromuscular dysplasia 10.0 ACE REN
32 diffuse glomerulonephritis 10.0 ALB B2M
33 non-secretory myeloma 10.0 ALB B2M
34 danubian endemic familial nephropathy 10.0 ALB B2M
35 coronary stenosis 10.0 ACE ALB
36 renal tubular dysgenesis 10.0 ACE REN
37 pure autonomic failure 10.0 ACE REN
38 renovascular hypertension 10.0 ACE REN
39 hemorrhagic fever 10.0 ALB B2M
40 hypersensitivity reaction type iv disease 10.0 ACE ENSG00000264813
41 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 ACE REN
42 acute kidney tubular necrosis 10.0 ALB B2M
43 retinal vascular disease 10.0 ACE ALB
44 meningoencephalitis 10.0 ALB B2M
45 hemorrhagic fever with renal syndrome 10.0 ALB B2M
46 heart valve disease 10.0 ACE REN
47 hydronephrosis 9.9 ALB B2M
48 immune system disease 9.9 ACE ALB C3
49 pyelitis 9.9 B2M REN
50 focal segmental glomerulosclerosis 1 9.9

Graphical network of the top 20 diseases related to Orthostatic Proteinuria:



Diseases related to Orthostatic Proteinuria

Symptoms & Phenotypes for Orthostatic Proteinuria

MGI Mouse Phenotypes related to Orthostatic Proteinuria:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.17 ACE B2M C3 HSP90AA1 MN1 REN

Drugs & Therapeutics for Orthostatic Proteinuria

Search Clinical Trials , NIH Clinical Center for Orthostatic Proteinuria

Genetic Tests for Orthostatic Proteinuria

Anatomical Context for Orthostatic Proteinuria

MalaCards organs/tissues related to Orthostatic Proteinuria:

41
Kidney, Heart

Publications for Orthostatic Proteinuria

Articles related to Orthostatic Proteinuria:

(show all 41)
# Title Authors Year
1
Urinary fibrin/fibrinogen degradation products measured using an anti-fibrinogen antibody predict orthostatic proteinuria. ( 29654610 )
2018
2
Adult orthostatic proteinuria. ( 25852903 )
2014
3
Renal vein obstruction and orthostatic proteinuria: a review. ( 20656752 )
2011
4
Orthostatic proteinuria: a harmless variant of protein loss? ( 21411841 )
2011
5
Left renal venographic findings in children with orthostatic proteinuria. ( 21636825 )
2011
6
Orthostatic proteinuria and the spectrum of diurnal variability of urinary protein excretion in healthy children. ( 20165888 )
2010
7
Multidetector computed tomography in orthostatic proteinuria? ( 20386925 )
2010
8
ACE inhibition in nutcracker syndrome with orthostatic proteinuria: how about a hemodynamic effect? ( 17333002 )
2007
9
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. ( 16902785 )
2006
10
The "nutcracker phenomenon" with orthostatic proteinuria: case reports. ( 16629228 )
2006
11
Nutcracker syndrome in children with orthostatic proteinuria: diagnosis on the basis of Doppler sonography. ( 11794401 )
2002
12
Diagnosis of nut-cracker phenomenon using renal Doppler ultrasound in orthostatic proteinuria. ( 11477164 )
2001
13
Orthostatic proteinuria as a result of venous compression (nutcracker phenomenon)--a hypothesis testable with modern imaging techniques. ( 10328451 )
1999
14
Left renal vein entrapment syndrome in two girls with orthostatic proteinuria. ( 9090670 )
1997
15
Mechanisms of orthostatic proteinuria: lessons from a transplant donor. ( 8400067 )
1993
16
Entrapment of left renal vein in children with orthostatic proteinuria. ( 1698439 )
1990
17
Mechanism of orthostatic proteinuria. ( 2206899 )
1990
18
Contribution to the aetiopathogenesis of orthostatic proteinuria in children: relation to the upper calyx syndrome. ( 2744992 )
1989
19
Incidence and clinical signs of the upper calyx syndrome and its relation to orthostatic proteinuria--a retrospective study. ( 2758702 )
1989
20
Progression of orthostatic proteinuria to focal and segmental glomerulosclerosis. ( 3948459 )
1986
21
Orthostatic proteinuria and milk ingestion. ( 4044380 )
1985
22
X-ray changes in the kidneys of children with orthostatic proteinuria. ( 6629677 )
1983
23
Fixed and reproducible orthostatic proteinuria: results of a 20-year follow-up study. ( 7125410 )
1982
24
Orthostatic proteinuria. ( 7138061 )
1982
25
Renal biopsy findings in orthostatic proteinuria. ( 7080809 )
1982
26
Prognosis in postural (orthostatic) proteinuria: forty to fifty-year follow-up of six patients after diagnosis by Thomas Addis. ( 7266586 )
1981
27
Postural (orthostatic) proteinuria: no causes for concern. ( 7266588 )
1981
28
Long-term outcome and clinical significance of orthostatic proteinuria. ( 7008153 )
1980
29
Contribution to the etiopathogenesis of orthostatic proteinuria in children. ( 591242 )
1977
30
Fixed and reproducible orthostatic proteinuria. VI. Results of a 10-year follow-up evaluation. ( 5454259 )
1970
31
Fixed and reproducible orthostatic proteinuria. V. Results of a 5-year follow-up evaluation. ( 5906444 )
1966
32
FIXED AND REPRODUCIBLE ORTHOSTATIC PROTEINURIA. IV. URINARY ALBUMIN EXCRETION BY HEALTHY HUMAN SUBJECTS IN THE RECUMBENT AND UPRIGHT POSTURES. ( 14226390 )
1964
33
Fixed and reproducible orthostatic proteinuria. III. Effect of induced renal hemodynamic alterations upon urinary protein excretion. ( 13974475 )
1963
34
Fixed and reproducible orthostatic proteinuria. I. Light microscopic studies of the kidney. ( 13742344 )
1961
35
Fixed and reproducible orthostatic proteinuria. II. Electron microscopy of renal biopsy specimens from five cases. ( 13742343 )
1961
36
Observations on aberrant renal arteries curving around and compressing the renal vein; possible relationship to orthostatic proteinuria and to orthostatic hypertension. ( 13608842 )
1958
37
ORTHOSTATIC proteinuria. ( 14368924 )
1955
38
Renal hemodynamics during erect lordosis in normal man and subjects with orthostatic proteinuria. ( 13204308 )
1954
39
Postural Albuminuria. ( 20311347 )
1919
40
A Note on Postural Albuminuria. ( 20761296 )
1904
41
The Prognosis of Postural Albuminuria. ( 29817382 )
1904

Variations for Orthostatic Proteinuria

Expression for Orthostatic Proteinuria

Search GEO for disease gene expression data for Orthostatic Proteinuria.

Pathways for Orthostatic Proteinuria

Pathways related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 ACE REN

GO Terms for Orthostatic Proteinuria

Cellular components related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ACE ALB B2M C3 HSP90AA1 REN
2 endoplasmic reticulum lumen GO:0005788 9.33 ALB B2M C3
3 extracellular space GO:0005615 9.1 ACE ALB B2M C3 ENSG00000264813 REN

Biological processes related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 ALB B2M C3
2 regulation of blood pressure GO:0008217 9.48 ACE REN
3 retina homeostasis GO:0001895 9.46 ALB B2M
4 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.4 ACE B2M
5 protein refolding GO:0042026 9.37 B2M HSP90AA1
6 positive regulation of blood pressure GO:0045777 9.32 ACE ENSG00000264813
7 amyloid-beta metabolic process GO:0050435 9.26 ACE REN
8 angiotensin maturation GO:0002003 9.16 ACE REN
9 proteolysis GO:0006508 9.02 ACE C3 ENSG00000264813 REN SPG7
10 positive regulation of systemic arterial blood pressure GO:0003084 8.96 ACE ENSG00000264813

Molecular functions related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.62 ACE ENSG00000264813 REN SPG7
2 metallopeptidase activity GO:0008237 9.43 ACE ENSG00000264813 SPG7
3 carboxypeptidase activity GO:0004180 9.37 ACE ENSG00000264813
4 dipeptidyl-peptidase activity GO:0008239 9.16 ACE ENSG00000264813
5 exopeptidase activity GO:0008238 8.96 ACE ENSG00000264813
6 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813

Sources for Orthostatic Proteinuria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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