MCID: ORT001
MIFTS: 30

Orthostatic Proteinuria

Categories: Nephrological diseases

Aliases & Classifications for Orthostatic Proteinuria

MalaCards integrated aliases for Orthostatic Proteinuria:

Name: Orthostatic Proteinuria 12 15 72
Postural Albuminuria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9617
ICD9CM 35 593.6
ICD10 33 N39.2 R80.2
UMLS 72 C0232867

Summaries for Orthostatic Proteinuria

MalaCards based summary : Orthostatic Proteinuria, also known as postural albuminuria, is related to iga glomerulonephritis and renal nutcracker syndrome. An important gene associated with Orthostatic Proteinuria is MN1 (MN1 Proto-Oncogene, Transcriptional Regulator), and among its related pathways/superpathways are FOXA2 and FOXA3 transcription factor networks and Development_Glucocorticoid receptor signaling. Affiliated tissues include kidney, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Related Diseases for Orthostatic Proteinuria

Diseases related to Orthostatic Proteinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 iga glomerulonephritis 29.8 REN ALB ACE
2 renal nutcracker syndrome 11.6
3 pyuria 10.6 MN1 ALB
4 ascending cholangitis 10.4 C3 ALB
5 loeffler syndrome 10.4 ALB ACE
6 corticosteroid-binding globulin deficiency 10.4 NR3C1 ALB
7 syndrome of inappropriate antidiuretic hormone 10.4 ALB ACE
8 hypertensive nephropathy 10.4 ALB ACE
9 benign essential hypertension 10.4 REN ALB
10 microvascular complications of diabetes 3 10.4 ALB ACE
11 kidney papillary necrosis 10.3 REN ALB
12 apparent mineralocorticoid excess 10.3 REN NR3C1
13 arteriolosclerosis 10.3 REN C3
14 henoch-schoenlein purpura 10.3 HSP90AA1 C3
15 immunodeficiency 43 10.3 B2M ALB
16 nephrotic syndrome 10.2
17 hypoaldosteronism 10.2 REN ACE
18 hyperaldosteronism, familial, type i 10.2 REN NR3C1
19 hepatic vascular disease 10.2 REN ALB
20 diffuse glomerulonephritis 10.2 B2M ALB
21 renal artery obstruction 10.2 REN ACE
22 non-secretory myeloma 10.2 B2M ALB
23 danubian endemic familial nephropathy 10.2 B2M ALB
24 hypertensive encephalopathy 10.2 REN ACE
25 hypertension, diastolic 10.2 REN ACE
26 renal artery disease 10.2 REN ACE
27 hypertensive retinopathy 10.2 REN ACE
28 malignant essential hypertension 10.2 REN ACE
29 membranoproliferative glomerulonephritis 10.2 C3 ALB
30 adrenal cortex disease 10.2 REN NR3C1
31 acute kidney tubular necrosis 10.2 B2M ALB
32 malignant hypertension 10.2 REN ACE
33 hypersensitivity reaction type iii disease 10.1 HSP90AA1 C3 ALB
34 fibromuscular dysplasia 10.1 REN ACE
35 adrenal gland disease 10.1 REN NR3C1
36 ptosis 10.1
37 glomerulonephritis 10.1
38 pure autonomic failure 10.1 REN ACE
39 renal tubular dysgenesis 10.1 REN ACE
40 intermittent claudication 10.1 ALB ACE
41 renovascular hypertension 10.0 REN ACE
42 hypersensitivity vasculitis 10.0 HSP90AA1 C3 ACE
43 hemorrhagic fever with renal syndrome 10.0 B2M ALB
44 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 REN ACE
45 pyelitis 10.0 REN B2M
46 renal tuberculosis 10.0 REN B2M
47 meningoencephalitis 10.0 B2M ALB
48 anuria 10.0 REN ALB ACE
49 hepatorenal syndrome 10.0 REN ALB ACE
50 renal hypertension 10.0 REN ALB ACE

Graphical network of the top 20 diseases related to Orthostatic Proteinuria:



Diseases related to Orthostatic Proteinuria

Symptoms & Phenotypes for Orthostatic Proteinuria

GenomeRNAi Phenotypes related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 ALB C3 HSP90AA1 NR3C1 RARA

MGI Mouse Phenotypes related to Orthostatic Proteinuria:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.09 ACE B2M C3 HSP90AA1 MN1 NR3C1
2 behavior/neurological MP:0005386 10.04 ACE C3 HSP90AA1 MN1 NR3C1 REN
3 endocrine/exocrine gland MP:0005379 10 ACE ALB B2M C3 HSP90AA1 NR3C1
4 mortality/aging MP:0010768 9.97 ACE ALB B2M C3 HSP90AA1 MN1
5 digestive/alimentary MP:0005381 9.95 ALB B2M C3 MN1 NR3C1 RARA
6 immune system MP:0005387 9.95 ACE B2M C3 HSP90AA1 NR3C1 RARA
7 liver/biliary system MP:0005370 9.85 ACE ALB B2M C3 NR3C1 RARA
8 neoplasm MP:0002006 9.65 ACE ALB B2M MN1 RARA
9 renal/urinary system MP:0005367 9.63 ACE ALB C3 NR3C1 RARA REN
10 reproductive system MP:0005389 9.5 ACE B2M C3 HSP90AA1 NR3C1 RARA
11 skeleton MP:0005390 9.02 C3 MN1 NR3C1 RARA SPG7

Drugs & Therapeutics for Orthostatic Proteinuria

Search Clinical Trials , NIH Clinical Center for Orthostatic Proteinuria

Genetic Tests for Orthostatic Proteinuria

Anatomical Context for Orthostatic Proteinuria

MalaCards organs/tissues related to Orthostatic Proteinuria:

41
Kidney

Publications for Orthostatic Proteinuria

Articles related to Orthostatic Proteinuria:

(show top 50) (show all 114)
# Title Authors PMID Year
1
High prevalence of underlying orthostatic proteinuria in young Japanese women. 38
30834612 2019
2
Simplified Algorithm for Evaluation of Proteinuria in Clinical Practice: How should A Clinician Approach? 38
30967921 2019
3
Orthostatic proteinuria due to smartphone use in bed. 38
30920105 2018
4
Nutcracker Syndrome in Children: Role of Doppler Ultrasonographic Indices in Detecting the Pattern of Symptoms. 38
30104539 2018
5
Urinary fibrin/fibrinogen degradation products measured using an anti-fibrinogen antibody predict orthostatic proteinuria. 38
29654610 2018
6
Nutcracker syndrome in adolescent with perineal pain: An interesting case of an adolescent with perineal pain due to pelvic congestion from nutcracker syndrome with relief after balloon venoplasty and sclerotherapy. 38
29487651 2018
7
Nutcracker syndrome: A rare cause of left flank pain that can also manifest as unexplained pelvic pain. 38
27932281 2017
8
Proteinuria in Children: Evaluation and Differential Diagnosis. 38
28290633 2017
9
Nutcracker syndrome. 38
25374822 2014
10
[Nutcracker syndrome: Cause of non-glomerular hematuria and massive proteinuria]. 38
29421619 2014
11
Urinalysis in children and adolescents. 38
25283761 2014
12
Adult orthostatic proteinuria. 38
25852903 2014
13
Clinical course of children with nutcracker syndrome. 38
23735609 2013
14
Endovascular stent placement for the treatment of nutcracker syndrome. 38
22086468 2012
15
Pediatric left renal vein entrapment syndrome diagnosed by 99mTc-albumin-conjugate scintigraphy. 38
23689519 2012
16
Erich Frank (1884-1957): unsung pioneer in nephrology. 38
21864962 2011
17
[Asymptomatic proteinuria in children]. 38
22028262 2011
18
Left renal venographic findings in children with orthostatic proteinuria. 38
21636825 2011
19
Renal vein obstruction and orthostatic proteinuria: a review. 38
20656752 2011
20
Orthostatic proteinuria: a harmless variant of protein loss? 38
21411841 2011
21
Multidetector computed tomography in orthostatic proteinuria? 38
20386925 2010
22
Proteinuria in children. 38
20842993 2010
23
A rare cause of recurrent hematuria in children: Nutcracker syndrome. 38
20007737 2010
24
[What is your diagnosis? Orthostatic proteinuria]. 38
20737392 2010
25
Orthostatic proteinuria and the spectrum of diurnal variability of urinary protein excretion in healthy children. 38
20165888 2010
26
Nutcracker syndrome in a child with familial Mediterranean fever (FMF) disease: renal ultrastructural features. 38
19031109 2009
27
Diagnosis and surgical treatment of nutcracker syndrome: a single-center experience. 38
19193424 2009
28
Blood pressure load, proteinuria and renal function in pre-hypertensive children. 38
19096881 2009
29
[Efficacy of Enalapril in patients with single kidney and with or without normoprotein diet]. 38
19030641 2008
30
ACE inhibition in nutcracker syndrome with orthostatic proteinuria: how about a hemodynamic effect? 38
17333002 2007
31
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. 38
16902785 2006
32
Urine proteomic profiling of pediatric nephrotic syndrome. 38
16810512 2006
33
The "nutcracker phenomenon" with orthostatic proteinuria: case reports. 38
16629228 2006
34
Left testicular artery arching over the ipsilateral renal vein. 38
16372128 2006
35
An ultrasonographic classification for diverse clinical symptoms of pediatric nutcracker phenomenon. 38
16047645 2005
36
[Hematuria and proteinuria in childhood]. 38
15790015 2005
37
Role of routine urinalysis in asymptomatic pediatric patients. 38
15678230 2005
38
[Differential diagnosis of proteinuria]. 38
15559519 2004
39
The role of body position and gravity in the symptoms and treatment of various medical diseases. 38
15551157 2004
40
[Orthostatic proteinuria or latent nephritis?]. 38
16136988 2004
41
[Orthostatic proteinuria and compression of the left renal vein (nutcracker syndrome)]. 38
12870396 2003
42
Isolated asymptomatic proteinuria. 38
12557959 2002
43
Nutcracker syndrome in children with orthostatic proteinuria: diagnosis on the basis of Doppler sonography. 38
11794401 2002
44
Diagnosis of nut-cracker phenomenon using renal Doppler ultrasound in orthostatic proteinuria. 38
11477164 2001
45
Proteinuria: potential causes and approach to evaluation. 38
11014373 2000
46
[Proteinuria in children: practical approach]. 38
10815456 2000
47
Does severe nutcracker phenomenon cause pediatric chronic fatigue? 38
10749295 2000
48
Orthostatic proteinuria as a result of venous compression (nutcracker phenomenon)--a hypothesis testable with modern imaging techniques. 38
10328451 1999
49
Evaluating proteinuria in children. 38
9787280 1998
50
Mesangial proliferative nephritis in man is associated with increased expression of the cell survival factor, Bcl-2. 38
9653832 1998

Variations for Orthostatic Proteinuria

Expression for Orthostatic Proteinuria

Search GEO for disease gene expression data for Orthostatic Proteinuria.

Pathways for Orthostatic Proteinuria

Pathways related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 NR3C1 ALB
2 10.77 NR3C1 HSP90AA1
3 10.49 NR3C1 HSP90AA1
4 9.62 NR3C1 HSP90AA1

GO Terms for Orthostatic Proteinuria

Cellular components related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.92 NR3C1 HSP90AA1 C3 ALB

Biological processes related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.58 SPG7 REN ACE
2 cellular protein metabolic process GO:0044267 9.5 C3 B2M ALB
3 retina homeostasis GO:0001895 9.37 B2M ALB
4 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.26 B2M ACE
5 protein refolding GO:0042026 9.16 HSP90AA1 B2M
6 amyloid-beta metabolic process GO:0050435 8.96 REN ACE
7 angiotensin maturation GO:0002003 8.62 REN ACE

Molecular functions related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.96 RARA NR3C1
2 drug binding GO:0008144 8.8 RARA ALB ACE

Sources for Orthostatic Proteinuria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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