MCID: ORT001
MIFTS: 30

Orthostatic Proteinuria

Categories: Nephrological diseases

Aliases & Classifications for Orthostatic Proteinuria

MalaCards integrated aliases for Orthostatic Proteinuria:

Name: Orthostatic Proteinuria 12 15 74
Postural Albuminuria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9617
ICD9CM 36 593.6
ICD10 34 R80.2
UMLS 74 C0232867

Summaries for Orthostatic Proteinuria

MalaCards based summary : Orthostatic Proteinuria, also known as postural albuminuria, is related to renal nutcracker syndrome and pyuria. An important gene associated with Orthostatic Proteinuria is MN1 (MN1 Proto-Oncogene, Transcriptional Regulator), and among its related pathways/superpathways is Renin secretion. Affiliated tissues include kidney, heart and eye, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Orthostatic Proteinuria

Diseases related to Orthostatic Proteinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 renal nutcracker syndrome 11.5
2 pyuria 10.3 ALB MN1
3 ascending cholangitis 10.2 ALB C3
4 immunodeficiency 43 10.2 ALB B2M
5 diffuse glomerulonephritis 10.2 ALB B2M
6 non-secretory myeloma 10.2 ALB B2M
7 danubian endemic familial nephropathy 10.2 ALB B2M
8 membranoproliferative glomerulonephritis 10.2 ALB C3
9 acute kidney tubular necrosis 10.1 ALB B2M
10 loeffler syndrome 10.1 ACE ALB
11 meningoencephalitis 10.1 ALB B2M
12 hemorrhagic fever with renal syndrome 10.1 ALB B2M
13 henoch-schoenlein purpura 10.1 C3 HSP90AA1
14 hydronephrosis 10.1 ALB B2M
15 hypertensive nephropathy 10.1 ACE ALB
16 syndrome of inappropriate antidiuretic hormone 10.1 ACE ALB
17 microvascular complications of diabetes 3 10.1 ACE ALB
18 intermittent claudication 10.1 ACE ALB
19 pyelonephritis 10.1 ACE ALB
20 coronary stenosis 10.0 ACE ALB
21 retinal vascular disease 10.0 ACE ALB
22 benign essential hypertension 10.0 ALB REN
23 kidney papillary necrosis 10.0 ALB REN
24 uremia 10.0 ALB B2M
25 arteriolosclerosis 10.0 C3 REN
26 peripheral vascular disease 10.0 ACE ALB
27 hepatic vascular disease 10.0 ALB REN
28 peritonitis 9.9 ALB B2M
29 bornholm eye disease 9.9
30 focal segmental glomerulosclerosis 1 9.9
31 end stage renal failure 9.9 ACE ALB
32 hypersensitivity reaction type iii disease 9.9 ALB C3 HSP90AA1
33 ovarian hyperstimulation syndrome 9.9 ALB REN
34 obstructive jaundice 9.9 ALB REN
35 pyelitis 9.9 B2M REN
36 renal tuberculosis 9.9 B2M REN
37 hypoaldosteronism 9.9 ACE REN
38 renal artery obstruction 9.9 ACE REN
39 hypertension, diastolic 9.9 ACE REN
40 hypertensive encephalopathy 9.9 ACE REN
41 hypertensive retinopathy 9.9 ACE REN
42 renal artery disease 9.9 ACE REN
43 malignant essential hypertension 9.9 ACE REN
44 myeloma, multiple 9.9 ALB B2M HSP90AA1
45 malignant hypertension 9.9 ACE REN
46 fibromuscular dysplasia 9.9 ACE REN
47 microvascular complications of diabetes 5 9.9 ACE ALB
48 renal tubular dysgenesis 9.8 ACE REN
49 pure autonomic failure 9.8 ACE REN
50 renovascular hypertension 9.8 ACE REN

Graphical network of the top 20 diseases related to Orthostatic Proteinuria:



Diseases related to Orthostatic Proteinuria

Symptoms & Phenotypes for Orthostatic Proteinuria

MGI Mouse Phenotypes related to Orthostatic Proteinuria:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ACE C3 HSP90AA1 MN1 REN SPG7
2 growth/size/body region MP:0005378 9.8 ACE B2M C3 HSP90AA1 MN1 REN
3 endocrine/exocrine gland MP:0005379 9.72 ACE ALB B2M C3 HSP90AA1
4 mortality/aging MP:0010768 9.7 ACE ALB B2M C3 HSP90AA1 MN1
5 neoplasm MP:0002006 9.26 ACE ALB B2M MN1
6 reproductive system MP:0005389 9.02 ACE B2M C3 HSP90AA1 REN

Drugs & Therapeutics for Orthostatic Proteinuria

Search Clinical Trials , NIH Clinical Center for Orthostatic Proteinuria

Genetic Tests for Orthostatic Proteinuria

Anatomical Context for Orthostatic Proteinuria

MalaCards organs/tissues related to Orthostatic Proteinuria:

42
Kidney, Heart, Eye

Publications for Orthostatic Proteinuria

Articles related to Orthostatic Proteinuria:

(show all 43)
# Title Authors Year
1
High prevalence of underlying orthostatic proteinuria in young Japanese women. ( 30834612 )
2019
2
Urinary fibrin/fibrinogen degradation products measured using an anti-fibrinogen antibody predict orthostatic proteinuria. ( 29654610 )
2018
3
Orthostatic proteinuria due to smartphone use in bed. ( 30920105 )
2018
4
Adult orthostatic proteinuria. ( 25852903 )
2014
5
Renal vein obstruction and orthostatic proteinuria: a review. ( 20656752 )
2011
6
Orthostatic proteinuria: a harmless variant of protein loss? ( 21411841 )
2011
7
Left renal venographic findings in children with orthostatic proteinuria. ( 21636825 )
2011
8
Orthostatic proteinuria and the spectrum of diurnal variability of urinary protein excretion in healthy children. ( 20165888 )
2010
9
Multidetector computed tomography in orthostatic proteinuria? ( 20386925 )
2010
10
ACE inhibition in nutcracker syndrome with orthostatic proteinuria: how about a hemodynamic effect? ( 17333002 )
2007
11
The "nutcracker phenomenon" with orthostatic proteinuria: case reports. ( 16629228 )
2006
12
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. ( 16902785 )
2006
13
Nutcracker syndrome in children with orthostatic proteinuria: diagnosis on the basis of Doppler sonography. ( 11794401 )
2002
14
Diagnosis of nut-cracker phenomenon using renal Doppler ultrasound in orthostatic proteinuria. ( 11477164 )
2001
15
Orthostatic proteinuria as a result of venous compression (nutcracker phenomenon)--a hypothesis testable with modern imaging techniques. ( 10328451 )
1999
16
Left renal vein entrapment syndrome in two girls with orthostatic proteinuria. ( 9090670 )
1997
17
Mechanisms of orthostatic proteinuria: lessons from a transplant donor. ( 8400067 )
1993
18
Entrapment of left renal vein in children with orthostatic proteinuria. ( 1698439 )
1990
19
Mechanism of orthostatic proteinuria. ( 2206899 )
1990
20
Contribution to the aetiopathogenesis of orthostatic proteinuria in children: relation to the upper calyx syndrome. ( 2744992 )
1989
21
Incidence and clinical signs of the upper calyx syndrome and its relation to orthostatic proteinuria--a retrospective study. ( 2758702 )
1989
22
Progression of orthostatic proteinuria to focal and segmental glomerulosclerosis. ( 3948459 )
1986
23
Orthostatic proteinuria and milk ingestion. ( 4044380 )
1985
24
X-ray changes in the kidneys of children with orthostatic proteinuria. ( 6629677 )
1983
25
Renal biopsy findings in orthostatic proteinuria. ( 7080809 )
1982
26
Fixed and reproducible orthostatic proteinuria: results of a 20-year follow-up study. ( 7125410 )
1982
27
Orthostatic proteinuria. ( 7138061 )
1982
28
Prognosis in postural (orthostatic) proteinuria: forty to fifty-year follow-up of six patients after diagnosis by Thomas Addis. ( 7266586 )
1981
29
Postural (orthostatic) proteinuria: no causes for concern. ( 7266588 )
1981
30
Long-term outcome and clinical significance of orthostatic proteinuria. ( 7008153 )
1980
31
Contribution to the etiopathogenesis of orthostatic proteinuria in children. ( 591242 )
1977
32
Fixed and reproducible orthostatic proteinuria. VI. Results of a 10-year follow-up evaluation. ( 5454259 )
1970
33
Fixed and reproducible orthostatic proteinuria. V. Results of a 5-year follow-up evaluation. ( 5906444 )
1966
34
FIXED AND REPRODUCIBLE ORTHOSTATIC PROTEINURIA. IV. URINARY ALBUMIN EXCRETION BY HEALTHY HUMAN SUBJECTS IN THE RECUMBENT AND UPRIGHT POSTURES. ( 14226390 )
1964
35
Fixed and reproducible orthostatic proteinuria. III. Effect of induced renal hemodynamic alterations upon urinary protein excretion. ( 13974475 )
1963
36
Fixed and reproducible orthostatic proteinuria. II. Electron microscopy of renal biopsy specimens from five cases. ( 13742343 )
1961
37
Fixed and reproducible orthostatic proteinuria. I. Light microscopic studies of the kidney. ( 13742344 )
1961
38
Observations on aberrant renal arteries curving around and compressing the renal vein; possible relationship to orthostatic proteinuria and to orthostatic hypertension. ( 13608842 )
1958
39
ORTHOSTATIC proteinuria. ( 14368924 )
1955
40
Renal hemodynamics during erect lordosis in normal man and subjects with orthostatic proteinuria. ( 13204308 )
1954
41
Postural Albuminuria. ( 20311347 )
1919
42
A Note on Postural Albuminuria. ( 20761296 )
1904
43
The Prognosis of Postural Albuminuria. ( 29817382 )
1904

Variations for Orthostatic Proteinuria

Expression for Orthostatic Proteinuria

Search GEO for disease gene expression data for Orthostatic Proteinuria.

Pathways for Orthostatic Proteinuria

Pathways related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.46 ACE REN

GO Terms for Orthostatic Proteinuria

Cellular components related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 ACE ALB B2M C3 HSP90AA1
2 extracellular space GO:0005615 9.55 ACE ALB B2M C3 REN
3 endoplasmic reticulum lumen GO:0005788 9.13 ALB B2M C3
4 extracellular region GO:0005576 9.1 ACE ALB B2M C3 HSP90AA1 REN

Biological processes related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.54 ACE REN SPG7
2 positive regulation of protein binding GO:0032092 9.46 ACE B2M
3 regulation of blood pressure GO:0008217 9.43 ACE REN
4 cellular protein metabolic process GO:0044267 9.43 ALB B2M C3
5 retina homeostasis GO:0001895 9.4 ALB B2M
6 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.32 ACE B2M
7 protein refolding GO:0042026 9.16 B2M HSP90AA1
8 amyloid-beta metabolic process GO:0050435 8.96 ACE REN
9 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 8.62 ACE ALB

Sources for Orthostatic Proteinuria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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