MCID: ORT001
MIFTS: 28

Orthostatic Proteinuria

Categories: Nephrological diseases

Aliases & Classifications for Orthostatic Proteinuria

MalaCards integrated aliases for Orthostatic Proteinuria:

Name: Orthostatic Proteinuria 12 15 73
Postural Albuminuria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9617
ICD10 33 R80.2
ICD9CM 35 593.6
UMLS 73 C0232867

Summaries for Orthostatic Proteinuria

MalaCards based summary : Orthostatic Proteinuria, also known as postural albuminuria, is related to renal nutcracker syndrome and pyuria. An important gene associated with Orthostatic Proteinuria is MN1 (MN1 Proto-Oncogene, Transcriptional Regulator). Affiliated tissues include kidney, and related phenotypes are liver/biliary system and neoplasm

Related Diseases for Orthostatic Proteinuria

Diseases related to Orthostatic Proteinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 renal nutcracker syndrome 11.0
2 pyuria 10.7 ALB MN1
3 cork-handlers' disease 10.7 ALB CD79A
4 ostertagiasis 10.7 ALB CD79A
5 dermatitis, atopic, 3 10.7 ALB CD79A
6 urethral syndrome 10.7 CD79A MN1
7 mesangial proliferative glomerulonephritis 10.7 CD79A SPG7
8 root caries 10.7 ALB CD79A
9 parotitis 10.6 ALB CD79A
10 yellow nail syndrome 10.6 ALB CD79A
11 marasmus 10.6 ALB CD79A
12 chronic graft versus host disease 10.6 ALB CD79A
13 focal dermal hypoplasia 10.6 ALB CD79A
14 acute maxillary sinusitis 10.6 C3 CD79A
15 protein-losing enteropathy 10.6 ALB CD79A
16 ulcerative stomatitis 10.6 ALB CD79A
17 pneumocystosis 10.6 ALB CD79A
18 anemia, autoimmune hemolytic 10.6 C3 CD79A
19 autoimmune disease of urogenital tract 10.6 ALB CD79A
20 monoclonal paraproteinemia 10.6 CD79A HSP90AA1
21 autoimmune disease of blood 10.5 C3 CD79A
22 occupational dermatitis 10.5 ALB C3
23 lipoid nephrosis 10.5 ALB CD79A
24 ascending cholangitis 10.5 ALB C3
25 dysentery 10.5 ALB CD79A
26 chronic maxillary sinusitis 10.5 C3 CD79A
27 proliferative glomerulonephritis 10.5 C3 CD79A
28 epidermolysis bullosa acquisita 10.5 CD79A HSP90AA1
29 protein-energy malnutrition 10.5 ALB CD79A
30 benign essential hypertension 10.5 ALB REN
31 kidney papillary necrosis 10.5 ALB REN
32 keratoconjunctivitis sicca 10.4 ALB CD79A
33 testicular torsion 10.3 ACE CD79A
34 hepatic vascular disease 10.3 ALB REN
35 hypertensive nephropathy 10.3 ACE ALB
36 syndrome of inappropriate antidiuretic hormone 10.3 ACE ALB
37 membranoproliferative glomerulonephritis 10.2 ALB C3 CD79A
38 granulomatous hepatitis 10.2 ACE CD79A
39 hyporeninemic hypoaldosteronism 10.2 ACE REN
40 loeffler syndrome 10.2 ACE ENSG00000264813
41 glomerulonephritis 10.2 ALB C3 CD79A
42 renal artery obstruction 10.2 ACE REN
43 hypoaldosteronism 10.2 ACE REN
44 guillain-barre syndrome 10.2 ALB CD79A
45 hypertensive encephalopathy 10.2 ACE REN
46 fiedler's myocarditis 10.2 ACE ENSG00000264813
47 hypertensive retinopathy 10.2 ACE REN
48 renal artery disease 10.2 ACE REN
49 hypertension, diastolic 10.1 ACE REN
50 sclerosing keratitis 10.1 B2M CD79A

Graphical network of the top 20 diseases related to Orthostatic Proteinuria:



Diseases related to Orthostatic Proteinuria

Symptoms & Phenotypes for Orthostatic Proteinuria

MGI Mouse Phenotypes related to Orthostatic Proteinuria:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.55 ACE ALB B2M C3 CD79A
2 neoplasm MP:0002006 9.35 ACE ALB B2M CD79A MN1
3 renal/urinary system MP:0005367 9.02 ACE ALB C3 CD79A REN

Drugs & Therapeutics for Orthostatic Proteinuria

Search Clinical Trials , NIH Clinical Center for Orthostatic Proteinuria

Genetic Tests for Orthostatic Proteinuria

Anatomical Context for Orthostatic Proteinuria

MalaCards organs/tissues related to Orthostatic Proteinuria:

41
Kidney

Publications for Orthostatic Proteinuria

Articles related to Orthostatic Proteinuria:

(show all 37)
# Title Authors Year
1
Urinary fibrin/fibrinogen degradation products measured using an anti-fibrinogen antibody predict orthostatic proteinuria. ( 29654610 )
2018
2
Adult orthostatic proteinuria. ( 25852903 )
2014
3
Renal vein obstruction and orthostatic proteinuria: a review. ( 20656752 )
2011
4
Orthostatic proteinuria: a harmless variant of protein loss? ( 21411841 )
2011
5
Left renal venographic findings in children with orthostatic proteinuria. ( 21636825 )
2011
6
Orthostatic proteinuria and the spectrum of diurnal variability of urinary protein excretion in healthy children. ( 20165888 )
2010
7
Multidetector computed tomography in orthostatic proteinuria? ( 20386925 )
2010
8
ACE inhibition in nutcracker syndrome with orthostatic proteinuria: how about a hemodynamic effect? ( 17333002 )
2007
9
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. ( 16902785 )
2006
10
The "nutcracker phenomenon" with orthostatic proteinuria: case reports. ( 16629228 )
2006
11
Nutcracker syndrome in children with orthostatic proteinuria: diagnosis on the basis of Doppler sonography. ( 11794401 )
2002
12
Diagnosis of nut-cracker phenomenon using renal Doppler ultrasound in orthostatic proteinuria. ( 11477164 )
2001
13
Orthostatic proteinuria as a result of venous compression (nutcracker phenomenon)--a hypothesis testable with modern imaging techniques. ( 10328451 )
1999
14
Left renal vein entrapment syndrome in two girls with orthostatic proteinuria. ( 9090670 )
1997
15
Mechanisms of orthostatic proteinuria: lessons from a transplant donor. ( 8400067 )
1993
16
Entrapment of left renal vein in children with orthostatic proteinuria. ( 1698439 )
1990
17
Mechanism of orthostatic proteinuria. ( 2206899 )
1990
18
Contribution to the aetiopathogenesis of orthostatic proteinuria in children: relation to the upper calyx syndrome. ( 2744992 )
1989
19
Incidence and clinical signs of the upper calyx syndrome and its relation to orthostatic proteinuria--a retrospective study. ( 2758702 )
1989
20
Progression of orthostatic proteinuria to focal and segmental glomerulosclerosis. ( 3948459 )
1986
21
Orthostatic proteinuria and milk ingestion. ( 4044380 )
1985
22
X-ray changes in the kidneys of children with orthostatic proteinuria. ( 6629677 )
1983
23
Fixed and reproducible orthostatic proteinuria: results of a 20-year follow-up study. ( 7125410 )
1982
24
Orthostatic proteinuria. ( 7138061 )
1982
25
Renal biopsy findings in orthostatic proteinuria. ( 7080809 )
1982
26
Prognosis in postural (orthostatic) proteinuria: forty to fifty-year follow-up of six patients after diagnosis by Thomas Addis. ( 7266586 )
1981
27
Postural (orthostatic) proteinuria: no causes for concern. ( 7266588 )
1981
28
Long-term outcome and clinical significance of orthostatic proteinuria. ( 7008153 )
1980
29
Contribution to the etiopathogenesis of orthostatic proteinuria in children. ( 591242 )
1977
30
Fixed and reproducible orthostatic proteinuria. VI. Results of a 10-year follow-up evaluation. ( 5454259 )
1970
31
Fixed and reproducible orthostatic proteinuria. V. Results of a 5-year follow-up evaluation. ( 5906444 )
1966
32
FIXED AND REPRODUCIBLE ORTHOSTATIC PROTEINURIA. IV. URINARY ALBUMIN EXCRETION BY HEALTHY HUMAN SUBJECTS IN THE RECUMBENT AND UPRIGHT POSTURES. ( 14226390 )
1964
33
Fixed and reproducible orthostatic proteinuria. III. Effect of induced renal hemodynamic alterations upon urinary protein excretion. ( 13974475 )
1963
34
Fixed and reproducible orthostatic proteinuria. I. Light microscopic studies of the kidney. ( 13742344 )
1961
35
Fixed and reproducible orthostatic proteinuria. II. Electron microscopy of renal biopsy specimens from five cases. ( 13742343 )
1961
36
ORTHOSTATIC proteinuria. ( 14368924 )
1955
37
Renal hemodynamics during erect lordosis in normal man and subjects with orthostatic proteinuria. ( 13204308 )
1954

Variations for Orthostatic Proteinuria

Expression for Orthostatic Proteinuria

Search GEO for disease gene expression data for Orthostatic Proteinuria.

Pathways for Orthostatic Proteinuria

GO Terms for Orthostatic Proteinuria

Cellular components related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.33 ALB B2M C3
2 external side of plasma membrane GO:0009897 9.13 ACE B2M CD79A
3 extracellular region GO:0005576 9.1 ACE ALB B2M C3 HSP90AA1 REN

Biological processes related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 ALB B2M C3
2 retina homeostasis GO:0001895 9.4 ALB B2M
3 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.32 ACE B2M
4 protein refolding GO:0042026 9.26 B2M HSP90AA1
5 amyloid-beta metabolic process GO:0050435 9.16 ACE REN
6 proteolysis GO:0006508 9.02 ACE C3 ENSG00000264813 REN SPG7
7 angiotensin maturation GO:0002003 8.96 ACE REN

Molecular functions related to Orthostatic Proteinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.46 ACE ENSG00000264813 REN SPG7
2 metallopeptidase activity GO:0008237 9.13 ACE ENSG00000264813 SPG7
3 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813

Sources for Orthostatic Proteinuria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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