MCID: OSG001
MIFTS: 36

Osgood-Schlatter's Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Osgood-Schlatter's Disease

MalaCards integrated aliases for Osgood-Schlatter's Disease:

Name: Osgood-Schlatter's Disease 12 15
Juvenile Osteochondrosis of Tibial Tubercle 12 73
Osgood-Schlatter Disease 12 59
Osteochondrosis 44 73
Aseptic Necrosis of the Tibial Tubercle 59
Osteochondritis of the Tibial Tubercle 59
Osteochondrosis of the Tibial Tubercle 59
Osteochondritis of Tibial Tubercle 12
Osteochondrosis of Proximal Tibia 12
Osteochondritis Juvenilis 73
Osgoodschlatter Disease 76

Classifications:



External Ids:

Disease Ontology 12 DOID:7489
MeSH 44 D055034
NCIt 50 C34874
SNOMED-CT 68 72047008 79353000
Orphanet 59 ORPHA97335
ICD10 via Orphanet 34 M93.2
UMLS via Orphanet 74 C0029376

Summaries for Osgood-Schlatter's Disease

Disease Ontology : 12 A bone inflammation disease that involves rupture of the growth plate in children located in tibia.

MalaCards based summary : Osgood-Schlatter's Disease, also known as juvenile osteochondrosis of tibial tubercle, is related to osteochondrosis and legg-calve-perthes disease. An important gene associated with Osgood-Schlatter's Disease is NDUFB9 (NADH:Ubiquinone Oxidoreductase Subunit B9). The drugs Anesthetics and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone and tibia.

Wikipedia : 76 Osgood�??Schlatter disease (OSD), also known as apophysitis of the tibial tubercle, is inflammation of... more...

Related Diseases for Osgood-Schlatter's Disease

Diseases related to Osgood-Schlatter's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 osteochondrosis 12.7
2 legg-calve-perthes disease 12.1
3 scheuermann disease 12.1
4 kohler's disease 12.0
5 blount's disease 11.9
6 panner disease 11.8
7 kienbock's disease 11.3
8 sinding-larsen-johansson disease 11.3
9 thiemann disease 11.3
10 freiberg's disease 11.1
11 blount disease, infantile 11.0
12 blount disease, adolescent 11.0
13 osteochondritis dissecans 10.4
14 osteoarthritis 10.4
15 attention deficit-hyperactivity disorder 10.3
16 stickler syndrome 10.3
17 hypogonadotropic hypogonadism 10.3
18 upington disease 10.2
19 sacral agenesis with vertebral anomalies 10.2
20 insulin-like growth factor i 10.1
21 osteomyelitis 10.1
22 spondylosis 10.1
23 hemoglobin lepore-beta-thalassemia syndrome 10.0 HBB HBD
24 thalassemia 10.0 HBB HBD
25 hemoglobin d disease 10.0 HBB HBD
26 malignant secondary hypertension 10.0 HBB HBD
27 hemoglobin e disease 10.0 HBB HBD
28 fetal hemoglobin quantitative trait locus 1 10.0 HBB HBD
29 kluver-bucy syndrome 10.0 HBB HBD
30 malignant essential hypertension 10.0 HBB HBD
31 blind loop syndrome 10.0 HBB HBD
32 pleuropneumonia 10.0 HBB HBD
33 blood group, globoside system 10.0 MRAP PRF1
34 blood protein disease 10.0 HBB HBD
35 endophthalmitis 10.0 MRAP PRF1
36 alpha thalassemia-intellectual disability syndrome type 1 9.9 HBB HBD
37 hemoglobin h disease 9.9 HBB HBD
38 purulent endophthalmitis 9.9 MRAP PRF1
39 osteoporosis 9.9
40 pyle disease 9.9
41 arthritis 9.9
42 spinal stenosis 9.9
43 scoliosis 9.9
44 nephrocalcinosis 9.9
45 ischemia 9.9
46 septic arthritis 9.9
47 fibromyalgia 9.9
48 pain - chronic 9.9
49 idiopathic avascular necrosis 9.9
50 sickle cell disease 9.9 HBB HBD

Graphical network of the top 20 diseases related to Osgood-Schlatter's Disease:



Diseases related to Osgood-Schlatter's Disease

Symptoms & Phenotypes for Osgood-Schlatter's Disease

Drugs & Therapeutics for Osgood-Schlatter's Disease

Drugs for Osgood-Schlatter's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2, Phase 3,Phase 1
2 Fibrin Tissue Adhesive Phase 2, Phase 3
3
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
4 Peripheral Nervous System Agents Phase 1, Phase 2
5 Diuretics, Potassium Sparing Phase 1, Phase 2
6 Anesthetics, Local Phase 1, Phase 2
7 Sodium Channel Blockers Phase 1, Phase 2
8 Anti-Arrhythmia Agents Phase 1, Phase 2
9 Central Nervous System Depressants Phase 1, Phase 2
10 Astragalus Not Applicable
11 Calcium, Dietary

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Treatment of the Osgood Schlatter Unknown status NCT02824172 Phase 3
2 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
3 Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial Completed NCT00560664 Phase 3
4 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
5 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379 Not Applicable
6 Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression Unknown status NCT02289976 Not Applicable
7 Osteochondritis Dissecans of the Knee Unknown status NCT01455987
8 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394 Not Applicable
9 Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee Completed NCT03385642
10 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
11 24 Month Follow-up of Patients With Osgood Schlatter (OSD) Recruiting NCT03589001
12 Human Bone Graft for Fixation of Osteochondral Defects in the Knee Joint Recruiting NCT03777735
13 An Observational, Prospective Study of Patients With Chondral and/or Osteochondral Defects of the Knee Treated With NAMIC Recruiting NCT03625180
14 AS: Ankle Spacer for Talar Osteochondral Defects Recruiting NCT03303690 Not Applicable
15 ReNu™ Marrow Stimulation Augmentation Recruiting NCT03036878 Not Applicable
16 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Recruiting NCT02397278 Not Applicable Platelet rich plasma (PRP)
17 Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee Recruiting NCT01754298 Not Applicable
18 Cytokine Profiles in Spondylodiscitis Recruiting NCT02554227
19 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects Active, not recruiting NCT02423629 Not Applicable
20 A Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects Not yet recruiting NCT03696394 Not Applicable
21 A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects Terminated NCT01209390
22 Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee Withdrawn NCT02308358
23 Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy Withdrawn NCT01631409 Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;Aspirin, Isosorbide mononitrate, Atenolol, Enalapril

Search NIH Clinical Center for Osgood-Schlatter's Disease

Cochrane evidence based reviews: osteochondrosis

Genetic Tests for Osgood-Schlatter's Disease

Anatomical Context for Osgood-Schlatter's Disease

MalaCards organs/tissues related to Osgood-Schlatter's Disease:

41
Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Osgood-Schlatter's Disease:

19
Tibia

Publications for Osgood-Schlatter's Disease

Articles related to Osgood-Schlatter's Disease:

(show all 40)
# Title Authors Year
1
Periosteal chondroma of the proximaltibia mimicking Osgood-Schlatter's disease. ( 23610879 )
2013
2
Doppler ultrasound and tibial tuberosity maturation status predicts pain in adolescent male athletes with Osgood-Schlatter's disease: a case series with comparison group and clinical interpretation. ( 22952406 )
2013
3
Bilateral tibial tubercle avulsion fractures associated with Osgood-Schlatter's disease. ( 18401485 )
2008
4
Pseudoarthrosis between a patellar tendon ossicle and the tibial tuberosity in Osgood-Schlatter's disease. ( 8680945 )
1996
5
Anterior cruciate ligament reconstruction in athletes with an ossicle associated with Osgood-Schlatter's disease. ( 8902129 )
1996
6
Osgood-Schlatter's disease complicating anterior cruciate ligament reconstruction. ( 8305110 )
1993
7
Mobility of tibial tuberosity in Osgood-Schlatter's disease. ( 1676815 )
1991
8
Tibia recurvatum as a complication of Osgood-Schlatter's disease: a report of two cases. ( 1860961 )
1991
9
A young wrestler with antecedent both-knee Osgood Schlatter's disease and JOCD. ( 1766335 )
1991
10
The coexistence of Osgood-Schlatter's disease with Sinding-Larsen-Johansson's disease. Case report in an adolescent soccer player. ( 2266766 )
1990
11
Osteochondrosis of the tibial tuberosity (Osgood-Schlatter's disease) ( 2926286 )
1989
12
Osteochondrosis of the tibial tuberosity (Osgood-Schlatter's disease) ( 2769094 )
1989
13
The sequelae of Osgood-Schlatter's disease in adults. ( 3182124 )
1988
14
Osgood-Schlatter's disease in adolescent athletes. Retrospective study of incidence and duration. ( 4025675 )
1985
15
Surgical treatment of Osgood-Schlatter's disease. ( 6863528 )
1983
16
Misleading radiological appearance of intra-articular loose body following Osgood-Schlatter's disease. ( 7165774 )
1982
17
Operative treatment for longstanding Osgood-Schlatter's disease. ( 7131358 )
1982
18
Patellar tendon avulsion as a complication of Osgood-Schlatter's disease. ( 7316015 )
1981
19
Unusual presentation of Osgood-Schlatter's disease. ( 7370198 )
1980
20
Osgood-Schlatter's disease, an emphasis on soft tissue changes in roentgen diagnosis. ( 515746 )
1979
21
Osgood-Schlatter's disease and tibial tuberosity development. ( 1277640 )
1976
22
Patellar tendon bursae in Osgood-Schlatter's disease. ( 4414993 )
1974
23
Osgood-Schlatter's disease--a review of 108 cases. ( 5129732 )
1971
24
Osgood-Schlatter's disease: cause of a misleading radiographic sign. ( 5135817 )
1971
25
Osgood-Schlatter's disease: etiology and treatment. ( 5774831 )
1969
26
Injection of the deep infrapatellar bursa for Osgood-Schlatter's disease. ( 5271370 )
1969
27
Osgood-Schlatter's disease in the ninth century. ( 5658911 )
1968
28
GENU RECURVATUM AFTER OSGOOD-SCHLATTER'S DISEASE; REPORT OF A CASE. ( 14302734 )
1965
29
THE PERIOSTEUM INCISION FOR THE TREATMENT OF OSGOOD-SCHLATTER'S DISEASE. ( 14234557 )
1963
30
Epiphysitis of accessory scaphoid-a painful condition of the foot similar to Osgood-Schlatter's disease at the knee. ( 14462307 )
1961
31
Manifestations of Osgood-Schlatter's disease in late teen age and early adulthood. ( 13855428 )
1960
32
Pathogenesis of Osgood-Schlatter's disease. ( 13559407 )
1958
33
Treatment of Osgood-Schlatter's disease (tibial tubercle epiphysitis); case reports. ( 13514329 )
1958
34
Clinical pathological correlation in Osgood-Schlatter's disease. ( 13556212 )
1958
35
Roentgenologic features of fracture of the tibial tuberosity (Osgood-Schlatter's disease). ( 13478504 )
1957
36
Osgood-Schlatter's disease in the army. ( 14354247 )
1955
37
Osgood-Schlatter's disease; its development and treatment. ( 14381849 )
1955
38
Osteochondritis of the tibial tubercles; Osgood Schlatter's disease. ( 14850953 )
1951
39
Osgood-Schlatter's disease. ( 18912091 )
1948
40
Osgood-Schlatter's disease. ( 18901329 )
1948

Variations for Osgood-Schlatter's Disease

Expression for Osgood-Schlatter's Disease

Search GEO for disease gene expression data for Osgood-Schlatter's Disease.

Pathways for Osgood-Schlatter's Disease

GO Terms for Osgood-Schlatter's Disease

Cellular components related to Osgood-Schlatter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 8.96 HBB HBD
2 haptoglobin-hemoglobin complex GO:0031838 8.62 HBB HBD

Biological processes related to Osgood-Schlatter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterooligomerization GO:0051291 9.32 HBB HBD
2 inner ear morphogenesis GO:0042472 9.26 CHD7 FRZB
3 oxygen transport GO:0015671 9.16 HBB HBD
4 cellular oxidant detoxification GO:0098869 9.13 EPX HBB HBD
5 hydrogen peroxide catabolic process GO:0042744 8.8 EPX HBB HBD

Molecular functions related to Osgood-Schlatter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.54 EPX HBB HBD
2 oxygen binding GO:0019825 9.4 HBB HBD
3 oxygen carrier activity GO:0005344 9.32 HBB HBD
4 organic acid binding GO:0043177 9.26 HBB HBD
5 haptoglobin binding GO:0031720 9.16 HBB HBD
6 hemoglobin alpha binding GO:0031721 8.96 HBB HBD
7 peroxidase activity GO:0004601 8.8 EPX HBB HBD

Sources for Osgood-Schlatter's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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