MCID: OSG001
MIFTS: 37

Osgood-Schlatter's Disease

Categories: Bone diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Osgood-Schlatter's Disease

MalaCards integrated aliases for Osgood-Schlatter's Disease:

Name: Osgood-Schlatter's Disease 11 14
Osgood-Schlatter Disease 11 58 75
Juvenile Osteochondrosis of Tibial Tubercle 11 71
Osteochondrosis 43 71
Aseptic Necrosis of the Tibial Tubercle 58
Osteochondrosis of the Tibial Tubercle 58
Osteochondritis of Tibial Tubercle 11
Osteochondrosis of Proximal Tibia 11
Osteochondritis Juvenilis 71

Characteristics:


Age Of Onset:

Osgood-Schlatter Disease: Adolescent,Childhood 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 11 DOID:7489
MeSH 43 D055034
NCIt 49 C34874
SNOMED-CT 68 72047008
ICD10 via Orphanet 32 M93.2
UMLS via Orphanet 72 C0029376
Orphanet 58 ORPHA97335
UMLS 71 C0029376 C0029429 C0729346

Summaries for Osgood-Schlatter's Disease

Orphanet: 58 Osgood-Schlatter disease is a traction apophysitis of the anterior tibial tubercle described in active adolescents and characterized by gradual onset of pain and swelling of the anterior knee causing limping that usually disappears at the end of growth.

MalaCards based summary: Osgood-Schlatter's Disease, also known as osgood-schlatter disease, is related to scheuermann disease and legg-calve-perthes disease. An important gene associated with Osgood-Schlatter's Disease is RPS13 (Ribosomal Protein S13). The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include tibia, bone and testis, and related phenotypes are knee pain and irregular proximal tibial epiphyses

Disease Ontology: 11 A bone inflammation disease that involves rupture of the growth plate in children located in tibia.

Wikipedia: 75 Osgood-Schlatter disease (OSD) is inflammation of the patellar ligament at the tibial tuberosity... more...

Related Diseases for Osgood-Schlatter's Disease

Diseases related to Osgood-Schlatter's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 scheuermann disease 11.6
2 legg-calve-perthes disease 11.5
3 kohler's disease 11.4
4 panner disease 11.3
5 freiberg's disease 11.1
6 osteochondrosis of the metatarsal bone 11.0
7 kienbock's disease 11.0
8 thiemann disease 10.9
9 blount disease, infantile 10.9
10 blount disease, adolescent 10.9
11 osteochondrosis of genetic origin 10.9
12 osteochondrosis 10.7
13 cartilage disease 10.6
14 paine syndrome 10.5
15 osseous heteroplasia, progressive 10.4
16 bursitis 10.4
17 radiculopathy 10.4
18 osteonecrosis 10.4
19 tendinopathy 10.4
20 arthropathy 10.4
21 osteoarthritis 10.4
22 spondylosis 10.3
23 spondylitis 10.3
24 enterocele 10.2
25 periarthritis 10.2
26 bone disease 10.2
27 blount's disease 10.2
28 juxtacortical chondroma 10.2
29 chondroma 10.2
30 osteochondritis dissecans 10.2
31 spinal cord disease 10.2
32 cleft palate, isolated 10.2
33 dysplasia epiphysealis hemimelica 10.2
34 exostoses, multiple, type i 10.2
35 attention deficit-hyperactivity disorder 10.2
36 enchondromatosis, multiple, ollier type 10.2
37 polykaryocytosis inducer 10.2
38 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.2
39 arts syndrome 10.2
40 astigmatism 10.2
41 tendinosis 10.2
42 stickler syndrome 10.2
43 hypogonadotropic hypogonadism 10.2
44 osteomyelitis 10.2
45 arteriovenous malformation 10.2
46 exostosis 10.2
47 enthesopathy 10.2
48 connective tissue disease 10.2
49 compartment syndrome 10.2
50 muscular atrophy 10.2

Graphical network of the top 20 diseases related to Osgood-Schlatter's Disease:



Diseases related to Osgood-Schlatter's Disease

Symptoms & Phenotypes for Osgood-Schlatter's Disease

Human phenotypes related to Osgood-Schlatter's Disease:

58 30 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 knee pain 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0030839
2 irregular proximal tibial epiphyses 58 30 Frequent (33%) Frequent (79-30%)
HP:0006456
3 difficulty walking 58 30 Frequent (33%) Frequent (79-30%)
HP:0002355
4 abnormal patella morphology 58 30 Frequent (33%) Frequent (79-30%)
HP:0003045
5 limited knee extension 58 30 Frequent (33%) Frequent (79-30%)
HP:0003066
6 difficulty running 58 30 Frequent (33%) Frequent (79-30%)
HP:0009046
7 shuffling gait 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002362
8 large knee 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0030866

Drugs & Therapeutics for Osgood-Schlatter's Disease

Drugs for Osgood-Schlatter's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
2 Anti-Arrhythmia Agents Phase 1, Phase 2
3 Sodium Channel Blockers Phase 1, Phase 2
4 Anesthetics, Local Phase 1, Phase 2
5 Anesthetics Phase 1, Phase 2
6 Diuretics, Potassium Sparing Phase 1, Phase 2
7
Cholecalciferol Approved, Nutraceutical, Vet_approved 67-97-0, 1406-16-2 5280795 10883523
8 Vitamins
9 Calciferol
10 Astragalus
11 Calcium, Dietary
12
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
2 Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents. Completed NCT01300754 Phase 1, Phase 2
3 Evaluation of Polymorphisms in the Vitamin D Receptor and Involved in Inflammation Associated With Vertebral Osteochondrosis Unknown status NCT04195529
4 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
5 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Unknown status NCT03625180
6 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
7 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394
8 Treatment of the Osgood Schlatter Disease by Immobilization ( Ankle Cruro Resin ) Versus Sporting Rest ( Reference Treatment ) : Randomized Controlled Study Completed NCT02824172
9 Treatment for Osgood Schlatter Patients With a Physiotherapy Program "TrOPhy-Study" Completed NCT04716608
10 A Prospective Investigation of Osgood Schlatter With 24 Month Follow-up Completed NCT03589001
11 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis in Adolescent Girls Completed NCT03851367
12 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
13 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Completed NCT02423629
14 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
15 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Completed NCT02397278 Platelet rich plasma (PRP)
16 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Completed NCT01754298
17 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
18 A Comparison of Two Different Treatment Approaches for Adolescents With Osgood Schlatter: A Randomized Controlled Superiority Trial (The SOGOOD Trial) Recruiting NCT05174182
19 Personalized Spine Study Group (PSSG) Registry of Patients With Personalized Spine Rod Implantation Recruiting NCT04601363
20 Study Protocol for a Prospective Observational Study to Evaluate the Clinical and Imaging Results of the Fresh Osteochondral Allograft Transplantation for Osteochondral Knee Lesions Recruiting NCT04236492
21 Multicentric Observational Study on the Use of a Human Bone Graft in Osteochondral Defects Recruiting NCT03777735
22 A Pilot Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects of the Talus Recruiting NCT03696394
23 The Effect of Rıgıd Brace on Spinopelvic Parameters and GAP Score in Adolescents With Structural Hyperkyphosis Recruiting NCT04924556
24 Amount of Correction of Torsional Deformity in Blount's Disease After Coronal Plane Deformity Correction by 8 Plate Hemiepiphysiodesis Not yet recruiting NCT05334862
25 Comparison of Facilitatory Kinesiology Taping With Combined Inhibitory and Facilitatory Kinesiology Taping Among University Students With Calf Tightness Not yet recruiting NCT05434780
26 A Prospective Trial on the Clinical Efficacy of the Ankle Spacer for the Surgical Treatment of Large, Multiple, Cystic and Secondary or Tertiary Osteochondral Defects of the Talus Terminated NCT03303690
27 Evaluation of the ReNu™ Amniotic Suspension Allograft After Marrow Stimulation in the Treatment of Osteochondral Defects Terminated NCT03036878
28 A Prospective, Open Label, Multi-centre, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects Terminated NCT01209390
29 Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee. Withdrawn NCT02308358
30 Personalized Spine Study Group Registry Withdrawn NCT03843476

Search NIH Clinical Center for Osgood-Schlatter's Disease

Cochrane evidence based reviews: osteochondrosis

Genetic Tests for Osgood-Schlatter's Disease

Anatomical Context for Osgood-Schlatter's Disease

Organs/tissues related to Osgood-Schlatter's Disease:

FMA: Tibia
MalaCards : Bone, Testis

Publications for Osgood-Schlatter's Disease

Articles related to Osgood-Schlatter's Disease:

(show top 50) (show all 346)
# Title Authors PMID Year
1
The posterior tibial slope and Insall-Salvati index in operative and nonoperative adolescent athletes with Osgood-Schlatter disease. 62
35075550 2022
2
Medial Proximal Tibia Physeal Overuse Injury of an Athlete. 62
35858155 2022
3
The mid-term effect of Osgood-Schlatter disease on knee function in young players from elite soccer academies. 62
36413052 2022
4
Basic Differences and Most Common Findings in Ultrasound Examinations of Musculoskeletal System in Children: A Narrative Literature Review. 62
36292459 2022
5
Hyperosmolar dextrose injection for Osgood-Schlatter disease: a double-blind, randomized controlled trial. 62
34673998 2022
6
Describing Frequencies of Lower-Limb Apophyseal Injuries in Children and Adolescents: A Systematic Review. 62
34009802 2022
7
Analgesic use in adolescents with patellofemoral pain or Osgood-Schlatter Disease: a secondary cross-sectional analysis of 323 subjects. 62
34860477 2022
8
The German version of the KOOS-Child questionnaire (Knee injury and Osteoarthritis Outcome Score for children) shows a good to excellent internal consistency and a high test-retest reliability in children with knee problems. 62
35907029 2022
9
Running-related injuries in middle school cross-country runners: Prevalence and characteristics of common injuries. 62
34053194 2022
10
Biological Bone Plate and Iliac Bone Autograft for Proximal Tibial Slope Changing Osteotomy in Genu Recurvatum. 62
35782834 2022
11
The Etiology and Risk Factors of Osgood-Schlatter Disease: A Systematic Review. 62
35740763 2022
12
Bursoscopic Ultrasound-Guided Ossicle Resection for Osgood-Schlatter Disease. 62
35646559 2022
13
Arthroscopic Resection of Symptomatic Tibial Tubercle Ossicles for Recalcitrant Osgood-Schlatter Disease Using a 2-Portal Technique. 62
35646564 2022
14
Osgood-Schlatter Disease: Appearance, Diagnosis and Treatment: A Narrative Review. 62
35742062 2022
15
Osgood-Schlatter Disease in youth elite football: Minimal time-loss and no association with clinical and ultrasonographic factors. 62
35305497 2022
16
Incidence and management of Osgood-Schlatter disease in general practice: retrospective cohort study. 62
34990396 2022
17
Deep Infrapatellar Bursitis in Preadolescent Baseball Players: A Cross-Sectional Study. 62
35321209 2022
18
Characteristics of the Kicking Motion in Adolescent Male Soccer Players Who Develop Osgood-Schlatter Disease: A Prospective Study. 62
35309237 2022
19
The Osgood-Schlatter disease: a large clinical series with evaluation of risk factors, natural course, and outcomes. 62
34427770 2022
20
The Biomechanics Effect of Hamstring Flexibility on the Risk of Osgood-Schlatter Disease. 62
35586681 2022
21
Osteochondroma of the Tibial Tubercle Masquerading as Osgood-Shlatter Disease: A Case Report. 62
35991755 2022
22
Therapeutic interventions in Osgood-Schlatter disease: A case report. 62
34918694 2021
23
[Medical assessment in the field of Social Act VII: pre-existing damage and causality of apophyseal injuries and detachments]. 62
34648057 2021
24
Muscle stiffness of the rectus femoris and vastus lateralis in children with Osgood-Schlatter disease. 62
34507092 2021
25
Is the Prognosis of Osgood-Schlatter Poorer Than Anticipated? A Prospective Cohort Study With 24-Month Follow-up. 62
34435066 2021
26
Prevalence of lateral patellofemoral maltracking and associated complications in patients with Osgood Schlatter disease. 62
33404668 2021
27
Posterior Tibial Slope is Increased in Patients With Tibial Tubercle Fractures and Osgood-Schlatter Disease. 62
33782370 2021
28
Nano-Arthroscopic Ultrasound-Guided Excision of Unresolved Osgood-Schlatter Disease. 62
34258207 2021
29
A systematic review on conservative treatment options for OSGOOD-Schlatter disease. 62
33744766 2021
30
Osgood-Schlatter Disease as a Possible Cause of Tibial Tuberosity Avulsion. 62
33728197 2021
31
Tibial tubercle fractures in children and adolescents: a large retrospective case series. 62
32694426 2021
32
A History of Eponyms in Traction Apophysitises. 62
34605759 2021
33
Surgical Treatment Outcomes of Unresolved Osgood-Schlatter Disease in Adolescent Athletes. 62
33815856 2021
34
Overuse Knee Pain in the Pediatric and Adolescent Athlete. 62
33156034 2020
35
Current management strategies in Osgood Schlatter: A cross-sectional mixed-method study. 62
32562293 2020
36
Simultaneous Bilateral Patellar Tendon Rupture in a Young Adult Male: A Case Report and Review of the Literature. 62
33133819 2020
37
Conservative treatment of Osgood-Schlatter disease among young professional soccer players. 62
32346752 2020
38
Separating the myths from facts: time to take another look at Osgood-Schlatter 'disease'. 62
31892535 2020
39
Chondroblastoma of the Distal Femur in an Adolescent. 62
32354316 2020
40
Infrapatellar bursal injection with dextrose and saline are both effective treatments for Osgood-Schlatter disease. Letter to editor for: No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double‑blind study https://doi.org/10.1007/s00402-019-03297-2. 62
31982926 2020
41
Activity Modification and Knee Strengthening for Osgood-Schlatter Disease: A Prospective Cohort Study. 62
32284945 2020
42
The Passive Mechanical Properties of Muscles and Tendons in Children Affected by Osgood-Schlatter Disease. 62
31343463 2020
43
Pain, Sports Participation, and Physical Function in Adolescents With Patellofemoral Pain and Osgood-Schlatter Disease: A Matched Cross-sectional Study. 62
31905093 2020
44
Increased Posterior Tibial Slope in Patients With Osgood-Schlatter Disease: A New Association. 62
32004085 2020
45
Osgood-Schlatter Lesion Removed Arthroscopically in an Adult Patient. 62
32328374 2020
46
An Assessment of International Classification of Diseases, 10th Revision, Clinical Modification, Codes Used to Describe Common Pediatric Orthopedic Conditions. 62
31930410 2020
47
No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double-blind study. 62
31713082 2020
48
Osgood-Schlatter disease: a 2020 update of a common knee condition in children. 62
31714260 2020
49
Is There a Relationship between Patellofemoral Alignment and Osgood-Schlatter Disease? A Case-Control Study. 62
30577051 2020
50
Mid inter-epicondyle trochlea intersection (MIELTI): Proposal of a new index for identifying the deepest part of the trochlea. 62
31703848 2019

Variations for Osgood-Schlatter's Disease

Expression for Osgood-Schlatter's Disease

Search GEO for disease gene expression data for Osgood-Schlatter's Disease.

Pathways for Osgood-Schlatter's Disease

GO Terms for Osgood-Schlatter's Disease

Sources for Osgood-Schlatter's Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....