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MCID: OSG001
MIFTS: 38

Osgood-Schlatter's Disease

Categories: Bone diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Osgood-Schlatter's Disease

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MalaCards integrated aliases for Osgood-Schlatter's Disease:

Name: Osgood-Schlatter's Disease 12 15
Osgood-Schlatter Disease 12 73 58
Juvenile Osteochondrosis of Tibial Tubercle 12 70
Osteochondrosis 44 70
Aseptic Necrosis of the Tibial Tubercle 58
Osteochondrosis of the Tibial Tubercle 58
Osteochondritis of Tibial Tubercle 12
Osteochondrosis of Proximal Tibia 12
Osteochondritis Juvenilis 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:7489
MeSH 44 D055034
NCIt 50 C34874
SNOMED-CT 67 72047008
ICD10 32 M92.52
ICD10 via Orphanet 33 M93.2
UMLS via Orphanet 71 C0029376
Orphanet 58 ORPHA97335
UMLS 70 C0029376 C0029429 C0729346
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Summaries for Osgood-Schlatter's Disease

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Disease Ontology : 12 A bone inflammation disease that involves rupture of the growth plate in children located in tibia.

MalaCards based summary : Osgood-Schlatter's Disease, also known as osgood-schlatter disease, is related to scheuermann disease and legg-calve-perthes disease. An important gene associated with Osgood-Schlatter's Disease is VSX1 (Visual System Homeobox 1). The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include tibia, bone and testis, and related phenotypes are knee pain and irregular proximal tibial epiphyses

Wikipedia : 73 Osgood-Schlatter disease (OSD) is inflammation of the patellar ligament at the tibial tuberosity... more...

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Related Diseases for Osgood-Schlatter's Disease

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Diseases related to Osgood-Schlatter's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 scheuermann disease 11.6
2 legg-calve-perthes disease 11.5
3 kohler's disease 11.4
4 panner disease 11.2
5 freiberg's disease 11.1
6 kienbock's disease 10.9
7 blount disease, infantile 10.9
8 thiemann disease 10.9
9 blount disease, adolescent 10.9
10 osteochondrosis of genetic origin 10.9
11 osteochondrosis of the metatarsal bone 10.9
12 osteochondrosis 10.6
13 osteochondritis dissecans 10.5
14 frozen shoulder 10.4
15 bursitis 10.4
16 osteoarthritis 10.4
17 tendinopathy 10.3
18 tendinitis 10.3
19 arthropathy 10.3
20 inflammatory spondylopathy 10.3
21 spondylosis 10.3
22 spondylitis 10.3
23 periarthritis 10.2
24 bone disease 10.2
25 osteonecrosis 10.2
26 blount's disease 10.2
27 juxtacortical chondroma 10.2
28 chondroma 10.2
29 idiopathic avascular necrosis 10.2
30 cleft palate, isolated 10.2
31 dysplasia epiphysealis hemimelica 10.2
32 attention deficit-hyperactivity disorder 10.2
33 polykaryocytosis inducer 10.2
34 uvula, bifid 10.2
35 astigmatism 10.2
36 body mass index quantitative trait locus 1 10.2
37 tendinosis 10.2
38 stickler syndrome 10.2
39 hypogonadotropic hypogonadism 10.2
40 osteomyelitis 10.2
41 arteriovenous malformation 10.2
42 exostosis 10.2
43 enthesopathy 10.2
44 compartment syndrome 10.2
45 muscular atrophy 10.2
46 hemophilic arthropathy 10.2
47 osteochondroma 10.2
48 slipped capital femoral epiphysis 10.2
49 trochlear dysplasia 10.2
50 sinding-larsen-johansson disease 10.2

Graphical network of the top 20 diseases related to Osgood-Schlatter's Disease:



Diseases related to Osgood-Schlatter's Disease
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Symptoms & Phenotypes for Osgood-Schlatter's Disease

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Human phenotypes related to Osgood-Schlatter's Disease:

58 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 knee pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0030839
2 irregular proximal tibial epiphyses 58 31 frequent (33%) Frequent (79-30%) HP:0006456
3 difficulty walking 58 31 frequent (33%) Frequent (79-30%) HP:0002355
4 abnormal patella morphology 58 31 frequent (33%) Frequent (79-30%) HP:0003045
5 limited knee extension 58 31 frequent (33%) Frequent (79-30%) HP:0003066
6 difficulty running 58 31 frequent (33%) Frequent (79-30%) HP:0009046
7 shuffling gait 58 31 occasional (7.5%) Occasional (29-5%) HP:0002362
8 large knee 58 31 occasional (7.5%) Occasional (29-5%) HP:0030866
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Drugs & Therapeutics for Osgood-Schlatter's Disease

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Drugs for Osgood-Schlatter's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
2 Anti-Arrhythmia Agents Phase 1, Phase 2
3 Sodium Channel Blockers Phase 1, Phase 2
4 Anesthetics Phase 1, Phase 2
5 Diuretics, Potassium Sparing Phase 1, Phase 2
6 Anesthetics, Local Phase 1, Phase 2
7
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
8 Vitamins
9 Calciferol
10 Calcium, Dietary
11 Astragalus
12
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
2 Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents. Completed NCT01300754 Phase 1, Phase 2
3 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
4 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Unknown status NCT03625180
5 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
6 Treatment of the Osgood Schlatter Disease by Immobilization ( Ankle Cruro Resin ) Versus Sporting Rest ( Reference Treatment ) : Randomized Controlled Study Completed NCT02824172
7 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394
8 A Prospective Investigation of Osgood Schlatter With 24 Month Follow-up Completed NCT03589001
9 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis in Adolescent Girls Completed NCT03851367
10 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Completed NCT01754298
11 Agili-Câ„¢ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Completed NCT02423629
12 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Completed NCT02397278 Platelet rich plasma (PRP)
13 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
14 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
15 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
16 Treatment for Osgood Schlatter Patients With a Physiotherapy Program "TrOPhy-Study" Recruiting NCT04716608
17 Evaluation of Polymorphisms in the Vitamin D Receptor and Involved in Inflammation Associated With Vertebral Osteochondrosis Recruiting NCT04195529
18 Multicentric Observational Study on the Use of a Human Bone Graft in Osteochondral Defects Recruiting NCT03777735
19 A Pilot Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects of the Talus Recruiting NCT03696394
20 Study Protocol for a Prospective Observational Study to Evaluate the Clinical and Imaging Results of the Fresh Osteochondral Allograft Transplantation for Osteochondral Knee Lesions Recruiting NCT04236492
21 Personalized Spine Study Group (PSSG) Registry of Patients With Personalized Spine Rod Implantation Recruiting NCT04601363
22 Evaluation of the ReNuâ„¢ Amniotic Suspension Allograft After Marrow Stimulation in the Treatment of Osteochondral Defects Terminated NCT03036878
23 A Prospective, Open Label, Multi-centre, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects Terminated NCT01209390
24 A Prospective Trial on the Clinical Efficacy of the Ankle Spacer for the Surgical Treatment of Large, Multiple, Cystic and Secondary or Tertiary Osteochondral Defects of the Talus Terminated NCT03303690
25 Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee. Withdrawn NCT02308358
26 Personalized Spine Study Group Registry Withdrawn NCT03843476

Search NIH Clinical Center for Osgood-Schlatter's Disease

Cochrane evidence based reviews: osteochondrosis

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Genetic Tests for Osgood-Schlatter's Disease

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Anatomical Context for Osgood-Schlatter's Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Osgood-Schlatter's Disease:

19
Tibia

MalaCards organs/tissues related to Osgood-Schlatter's Disease:

40
Bone, Testis
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Publications for Osgood-Schlatter's Disease

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Articles related to Osgood-Schlatter's Disease:

(show top 50) (show all 317)
# Title Authors PMID Year
1
Posterior Tibial Slope is Increased in Patients With Tibial Tubercle Fractures and Osgood-Schlatter Disease. 61
33782370 2021
2
A systematic review on conservative treatment options for OSGOOD-Schlatter disease. 61
33744766 2021
3
Osgood-Schlatter Disease as a Possible Cause of Tibial Tuberosity Avulsion. 61
33728197 2021
4
Tibial tubercle fractures in children and adolescents: a large retrospective case series. 61
32694426 2021
5
Prevalence of lateral patellofemoral maltracking and associated complications in patients with Osgood Schlatter disease. 61
33404668 2021
6
Overuse Knee Pain in the Pediatric and Adolescent Athlete. 61
33156034 2020
7
Current management strategies in Osgood Schlatter: A cross-sectional mixed-method study. 61
32562293 2020
8
Conservative treatment of Osgood-Schlatter disease among young professional soccer players. 61
32346752 2020
9
Simultaneous Bilateral Patellar Tendon Rupture in a Young Adult Male: A Case Report and Review of the Literature. 61
33133819 2020
10
Separating the myths from facts: time to take another look at Osgood-Schlatter 'disease'. 61
31892535 2020
11
Chondroblastoma of the Distal Femur in an Adolescent. 61
32354316 2020
12
The Passive Mechanical Properties of Muscles and Tendons in Children Affected by Osgood-Schlatter Disease. 61
31343463 2020
13
Infrapatellar bursal injection with dextrose and saline are both effective treatments for Osgood-Schlatter disease. Letter to editor for: No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double‑blind study https://doi.org/10.1007/s00402-019-03297-2. 61
31982926 2020
14
Activity Modification and Knee Strengthening for Osgood-Schlatter Disease: A Prospective Cohort Study. 61
32284945 2020
15
Increased Posterior Tibial Slope in Patients With Osgood-Schlatter Disease: A New Association. 61
32004085 2020
16
Pain, Sports Participation, and Physical Function in Adolescents With Patellofemoral Pain and Osgood-Schlatter Disease: A Matched Cross-sectional Study. 61
31905093 2020
17
Osgood-Schlatter Lesion Removed Arthroscopically in an Adult Patient. 61
32328374 2020
18
An Assessment of International Classification of Diseases, 10th Revision, Clinical Modification, Codes Used to Describe Common Pediatric Orthopedic Conditions. 61
31930410 2020
19
No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double-blind study. 61
31713082 2020
20
Osgood-Schlatter disease: a 2020 update of a common knee condition in children. 61
31714260 2020
21
Is There a Relationship between Patellofemoral Alignment and Osgood-Schlatter Disease? A Case-Control Study. 61
30577051 2020
22
Clinics in diagnostic imaging (202). Osgood-Schlatter disease (OSD). 61
31889206 2019
23
Mid inter-epicondyle trochlea intersection (MIELTI): Proposal of a new index for identifying the deepest part of the trochlea. 61
31703848 2019
24
Benign bone tumours of tibial tuberosity clinically mimicking Osgood-Schlatter disease: a case series. 61
31511951 2019
25
Long-term Prognosis and Impact of Osgood-Schlatter Disease 4 Years After Diagnosis: A Retrospective Study. 61
31700938 2019
26
Screening of the Maturity Status of the Tibial Tuberosity by Ultrasonography in Higher Elementary School Grade Schoolchildren. 61
31212938 2019
27
Relationship Between Lower Limb Tightness and Practice Time Among Adolescent Baseball Players With Symptomatic Osgood-Schlatter Disease. 61
31192270 2019
28
Not just for boys: a rare case of symptomatic Osgood-Schlatter disease in a skeletally mature woman. 61
30914412 2019
29
[Knee pain in children and adolescents]. 61
30935452 2019
30
Bilateral Simultaneous Tibial Tubercle Avulsion in an Adolescent Football Player with Previous Bilateral Osgood-Schlatter Disease. 61
31019825 2019
31
Repair of Patellar Tendon Avulsion from the Tibial Tubercle: Case Report. 61
32547998 2019
32
Increased Patellar Volume/Width and Decreased Femoral Trochlear Width Are Associated With Adolescent Patellofemoral Pain. 61
30422967 2018
33
Osgood-Schlatter Disease Unveiled Under High-frequency Ultrasonogram. 61
30538899 2018
34
Pathogenic Factors Associated With Osgood-Schlatter Disease in Adolescent Male Soccer Players: A Prospective Cohort Study. 61
30182029 2018
35
Epidemiology of Existing Extensor Mechanism Pathology in Primary Anterior Cruciate Ligament Ruptures in an Active-Duty Population. 61
30180220 2018
36
Intra-articular Large Ossicle Associated to Osgood-Schlatter Disease. 61
30250770 2018
37
Anterior Knee Pain in Children and Adolescents: Overview and Management. 61
29490405 2018
38
Osgood-Schlatter Disease. 61
29539285 2018
39
Risk assessment of the onset of Osgood-Schlatter disease using kinetic analysis of various motions in sports. 61
29309422 2018
40
Bony Maturity of the Tibial Tuberosity With Regard to Age and Sex and Its Relationship to Pathogenesis of Osgood-Schlatter Disease: An Ultrasonographic Study. 61
29344541 2018
41
Therapeutic interventions in children and adolescents with patellar tendon related pain: a systematic review. 61
30167318 2018
42
Treatment of Osgood-Schlatter disease: review of the literature. 61
28593576 2017
43
[Osgood-Schlatter disease in adolescent athlete. Case report]. 61
29087132 2017
44
Acute traumatic rupture of the patellar tendon in pediatric population: Case series and review of the literature. 61
28888715 2017
45
Successful Treatment of Osgood-Schlatter Disease with Autologous-Conditioned Plasma in Two Patients. 61
29270553 2017
46
Reduction Osteotomy of the Prominent Tibial Tubercle After Osgood-Schlatter Disease. 61
28454996 2017
47
Editorial Commentary: Tibial Tubercle Prominence After Osgood-Schlatter Disease: What Causes Pain? 61
28779800 2017
48
Evaluation and management of knee pain in young athletes: overuse injuries of the knee. 61
28795010 2017
49
Unilateral striae distensae of the knee after a steroid injection for the treatment of Osgood-Schlatter disease. 61
28329528 2017
50
Results of arthroscopic treatment in unresolved Osgood-Schlatter disease in athletes. 61
27999926 2017
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Variations for Osgood-Schlatter's Disease

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Expression for Osgood-Schlatter's Disease

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Search GEO for disease gene expression data for Osgood-Schlatter's Disease.
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Pathways for Osgood-Schlatter's Disease

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GO Terms for Osgood-Schlatter's Disease

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Cellular components related to Osgood-Schlatter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 8.62 COL8A2 COL11A2

Molecular functions related to Osgood-Schlatter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.16 COL8A2 COL11A2
2 protein binding, bridging GO:0030674 8.96 COL8A2 COL11A2
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL8A2 COL11A2
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Sources for Osgood-Schlatter's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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