MCID: OSM001
MIFTS: 32

Osmotic Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Osmotic Diarrhea

MalaCards integrated aliases for Osmotic Diarrhea:

Name: Osmotic Diarrhea 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050130
UMLS 71 C0267556

Summaries for Osmotic Diarrhea

Disease Ontology : 12 Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

MalaCards based summary : Osmotic Diarrhea is related to diarrhea and secretory diarrhea, and has symptoms including diarrhea An important gene associated with Osmotic Diarrhea is WNT2B (Wnt Family Member 2B), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glycosaminoglycan metabolism. The drugs Clavulanate and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotype is digestive/alimentary.

Related Diseases for Osmotic Diarrhea

Graphical network of the top 20 diseases related to Osmotic Diarrhea:



Diseases related to Osmotic Diarrhea

Symptoms & Phenotypes for Osmotic Diarrhea

UMLS symptoms related to Osmotic Diarrhea:


diarrhea

MGI Mouse Phenotypes related to Osmotic Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 CDHR2 GUCA2A SLC26A3 SLC5A1 SLC9A2 SLC9A3

Drugs & Therapeutics for Osmotic Diarrhea

Drugs for Osmotic Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3 Anti-Infective Agents Phase 4
4 Anti-Bacterial Agents Phase 4
5 Acidophilus Phase 4
6 Amoxicillin-Potassium Clavulanate Combination Phase 4
7 Antibiotics, Antitubercular Phase 4
8 beta-Lactamase Inhibitors Phase 4
9 Hypolipidemic Agents Phase 2
10 Cholestyramine Resin Phase 2
11 Anticholesteremic Agents Phase 2
12 Lipid Regulating Agents Phase 2
13 Antimetabolites Phase 2
14
Erythromycin Approved, Investigational, Vet_approved 114-07-8 12560 441411
15 Erythromycin Estolate
16 Erythromycin stearate
17 Erythromycin Ethylsuccinate
18 Gastrointestinal Agents
19 Cathartics
20 Laxatives
21 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children: Prospective, Multi-center, Randomize, Parallel Group Placebo Controlled Clinical Trial Recruiting NCT02765217 Phase 4 Lactobacillus reuteri DSM 17938;Placebo;Amoxicillin-Clavulanic Acid
2 A Phase IIa, Proof of Concept, Randomized, Double-Blind, Dose-Finding, Cross-Over Study of the Efficacy, Safety and Tolerability of a New Enteric-Coated Cholestyramine Capsule in Adult Short Bowel Syndrome Patients Recruiting NCT04046328 Phase 2 Enteric-Coated Cholestyramine (ECC) Capsule;Placebo
3 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297
4 Comparative Study Between Different Methods of Enteral Feeding in Acute Severe Pancreatitis Completed NCT04406506 (erythromycin 250 mg IV bolus)
5 Prevalence of Idiopathic Reactive Hypoglycaemia and Impact of Fructo-Oligosaccharide Supplementation on Blood Glucose Variability Completed NCT00802971
6 Stability of the Intestinal Microbiome in Patients Suffering From Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS) Under the Influence of an Osmotic Laxans Recruiting NCT03395548 Macrogol

Search NIH Clinical Center for Osmotic Diarrhea

Genetic Tests for Osmotic Diarrhea

Anatomical Context for Osmotic Diarrhea

MalaCards organs/tissues related to Osmotic Diarrhea:

40
Colon, Small Intestine, Liver, Testes

Publications for Osmotic Diarrhea

Articles related to Osmotic Diarrhea:

(show top 50) (show all 111)
# Title Authors PMID Year
1
Chronic Diarrhea in Adults: Evaluation and Differential Diagnosis. 61
32293842 2020
2
Stool Reducing Sugars and Stool pH Are Poor Screening Tests for Intestinal Disaccharidase Deficiencies in Children. 61
32445391 2020
3
Sorbitol: Often forgotten cause of osmotic diarrhea. 61
31413027 2019
4
Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. 61
30359099 2019
5
Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. 61
29909964 2018
6
Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota. 61
29906449 2018
7
Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System. 61
30344249 2018
8
SLC5A1 Mutations in Saudi Arabian Patients With Congenital Glucose-Galactose Malabsorption. 61
28753187 2018
9
HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli. 61
30131942 2018
10
Comparison of a commercially available oral nutritional supplement and intravenous fluid therapy for dehydration in dairy calves. 61
28390725 2017
11
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. 61
28618266 2017
12
Effectiveness of three commonly used transition phase diets in the inpatient management of children with severe acute malnutrition: a pilot randomized controlled trial in Malawi. 61
28446221 2017
13
Two Cases of Mistaken Polyuria and Nephrocalcinosis in Infants with Glucose-Galactose Malabsorption: A Possible Role of 1,25(OH)2D3
. 61
28152538 2017
14
The multiple roles of sucrase-isomaltase in the intestinal physiology. 61
26812950 2016
15
Celiac Disease Presenting as Profound Diarrhea and Weight Loss - A Celiac Crisis. 61
27492679 2016
16
Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals. 61
27840639 2016
17
Is fructose malabsorption a cause of irritable bowel syndrome? 61
26059250 2015
18
Zinc treatment ameliorates diarrhea and intestinal inflammation in undernourished rats. 61
25095704 2014
19
The effects of sodium sulfate in the water of nursery pigs and the efficacy of nonnutritive feed additives to mitigate those effects. 61
24981569 2014
20
Bitterness of glucose/galactose: novel mutations in the SLC5A1 gene. 61
24048166 2014
21
Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations. 61
23382066 2013
22
Alterations in the colonic microbiota in response to osmotic diarrhea. 61
23409050 2013
23
Cola-induced hypokalemia-a case report and review of the literature. 61
23186978 2013
24
Clinical approach to diarrhea. 61
23073866 2012
25
Diarrhea caused by circulating agents. 61
22917166 2012
26
Intravenous hypertonic saline solution (7.5%) and oral electrolytes to treat of calves with noninfectious diarrhea and metabolic acidosis. 61
22708669 2012
27
Developmental toxicity evaluations of whole mixtures of disinfection by-products using concentrated drinking water in rats: gestational and lactational effects of sulfate and sodium. 61
22495758 2012
28
Effects of papaya seeds extract on the sperm characteristics of dogs. 61
22030338 2011
29
Approach to fecal incontinence and constipation in older hospitalized patients. 61
21441765 2011
30
Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression. 61
20219227 2010
31
Colon in acute intestinal infection. 61
19300128 2009
32
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects. 61
18797153 2008
33
Glucose Galactose Malabsorption complicated with Rickets and Nephrogenic Diabetes Insipidus. 61
22359715 2008
34
Chronic hypokalemia due to excessive cola consumption: a case report. 61
18625064 2008
35
[Chronic diarrhea: etiologies and diagnostic evaluation]. 61
18557018 2008
36
Liver transplantation for progressive familial intrahepatic cholestasis: clinical and histopathological findings, outcome and impact on growth. 61
17663686 2007
37
Lactulose feeding lowers cecal densities of clostridia in piglets. 61
17463144 2007
38
Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway. 61
17301139 2007
39
Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. 61
17171792 2006
40
Mechanism of diarrhea in microscopic colitis. 61
16222750 2005
41
A review of the clinical toleration studies of polydextrose in food. 61
15234083 2004
42
Randomized, double-blind clinical trial of a lactose-free and a lactose-containing formula in dietary management of acute childhood diarrhea. 61
15279342 2004
43
Effects of prefeeding a prebiotic on diarrhea and colonic cell proliferation in piglets fed lactulose. 61
14763789 2004
44
Toxicity of excipients--a Food and Drug Administration perspective. 61
14555410 2003
45
[Diarrhea]. 61
12426943 2002
46
Enteric pathogens, intestinal permeability and nitric oxide production in acute gastroenteritis. 61
12192160 2002
47
Small bowel intestinal permeability in Australian aboriginal children. 61
12187299 2002
48
Effect of wheat enzyme preparation on the performance characteristics of Tom turkeys fed wheat-based rations. 61
12162360 2002
49
[Effects of secretory and osmotic diarrhea on rats intestinal function and morphology]. 61
12214542 2002
50
Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. 61
11677212 2001

Variations for Osmotic Diarrhea

Expression for Osmotic Diarrhea

Search GEO for disease gene expression data for Osmotic Diarrhea.

Pathways for Osmotic Diarrhea

Pathways related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 SLC9A3 SLC9A2 SLC5A1 SLC2A5 SLC2A2 SLC26A3
2
Show member pathways
12.41 SLC5A1 SLC2A5 SLC2A2 MGAM LCT
3 11.71 SLC5A1 SLC2A5 SLC2A2
4
Show member pathways
11.5 SLC5A1 SLC2A5 SLC2A2
5 10.9 SLC9A3 SLC5A1 SLC26A3
6 10.69 SLC5A1 SLC2A5 SLC2A2 MGAM LCT
7 10.11 MGAM LCT

GO Terms for Osmotic Diarrhea

Cellular components related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.31 UGCG STXBP2 STX3 SLC9A3 SLC9A2 SLC5A1
2 plasma membrane GO:0005886 10.03 STXBP2 STX3 SLC9A3 SLC9A2 SLC5A1 SLC2A5
3 integral component of plasma membrane GO:0005887 10 SLC5A1 SLC2A5 SLC2A2 SLC26A3 LCT CDHR5
4 extracellular exosome GO:0070062 9.97 STXBP2 STX3 SLC9A3 SLC5A1 SLC2A5 MGAM
5 integral component of membrane GO:0016021 9.97 UGCG STXBP2 STX3 SLC9A3 SLC9A2 SLC5A1
6 cell-cell junction GO:0005911 9.71 STX3 SLC5A1 SLC2A2
7 microvillus membrane GO:0031528 9.51 CDHR5 CDHR2
8 brush border GO:0005903 9.5 SLC9A3 SLC2A2 CDHR2
9 specific granule GO:0042581 9.48 STXBP2 STX3
10 spanning component of plasma membrane GO:0044214 9.46 CDHR5 CDHR2
11 zymogen granule membrane GO:0042589 9.43 STXBP2 STX3
12 azurophil granule GO:0042582 9.4 STXBP2 STX3
13 apical plasma membrane GO:0016324 9.36 STXBP2 STX3 SLC9A3 SLC5A1 SLC2A5 SLC2A2
14 brush border membrane GO:0031526 9.35 SLC9A3 SLC5A1 SLC26A3 CDHR5 CDHR2

Biological processes related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.8 SLC2A5 SLC2A2 MGAM LCT
2 transmembrane transport GO:0055085 9.8 SLC9A3 SLC9A2 SLC5A1 SLC2A5 SLC2A2 SLC26A3
3 sodium ion transport GO:0006814 9.69 SLC9A3 SLC9A2 SLC5A1
4 anion transmembrane transport GO:0098656 9.58 SLC9A3 SLC9A2 SLC26A3
5 regulation of intracellular pH GO:0051453 9.54 SLC9A3 SLC9A2
6 carbohydrate transport GO:0008643 9.54 SLC5A1 SLC2A5 SLC2A2
7 regulation of pH GO:0006885 9.52 SLC9A3 SLC9A2
8 regulation of microvillus length GO:0032532 9.48 CDHR5 CDHR2
9 polysaccharide digestion GO:0044245 9.46 MGAM LCT
10 fructose transmembrane transport GO:0015755 9.43 SLC2A5 SLC2A2
11 glucose transmembrane transport GO:1904659 9.33 SLC5A1 SLC2A5 SLC2A2
12 intermicrovillar adhesion GO:0090675 9.26 CDHR5 CDHR2
13 sodium ion import across plasma membrane GO:0098719 9.13 SLC9A3 SLC9A2 SLC5A1
14 intestinal hexose absorption GO:0106001 8.8 SLC5A1 SLC2A5 SLC2A2

Molecular functions related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.63 SLC5A1 SLC2A5 SLC2A2
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.43 MGAM LCT
3 antiporter activity GO:0015297 9.43 SLC9A3 SLC9A2 SLC26A3
4 solute:proton antiporter activity GO:0015299 9.4 SLC9A3 SLC9A2
5 sodium:proton antiporter activity GO:0015385 9.37 SLC9A3 SLC9A2
6 potassium:proton antiporter activity GO:0015386 9.32 SLC9A3 SLC9A2
7 D-glucose transmembrane transporter activity GO:0055056 9.16 SLC5A1 SLC2A2
8 fructose transmembrane transporter activity GO:0005353 8.96 SLC2A5 SLC2A2
9 glucose transmembrane transporter activity GO:0005355 8.8 SLC5A1 SLC2A5 SLC2A2

Sources for Osmotic Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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