MCID: OSM001
MIFTS: 24

Osmotic Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Osmotic Diarrhea

MalaCards integrated aliases for Osmotic Diarrhea:

Name: Osmotic Diarrhea 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050130
UMLS 74 C0267556

Summaries for Osmotic Diarrhea

Disease Ontology : 12 Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

MalaCards based summary : Osmotic Diarrhea is related to diarrhea and diarrhea 9, and has symptoms including diarrhea An important gene associated with Osmotic Diarrhea is SLC5A1 (Solute Carrier Family 5 Member 1), and among its related pathways/superpathways are Mineral absorption and Carbohydrate digestion and absorption. The drugs Teduglutide and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon and small intestine.

Related Diseases for Osmotic Diarrhea

Diseases related to Osmotic Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diarrhea 29.8 LCT SLC26A3 SLC5A1
2 diarrhea 9 11.3
3 trehalase deficiency 11.2
4 shigellosis 9.9
5 diarrhea 2, with microvillus atrophy 9.7 SLC26A3 STXBP2
6 lactose intolerance 9.7 LCT SLC5A1

Graphical network of the top 20 diseases related to Osmotic Diarrhea:



Diseases related to Osmotic Diarrhea

Symptoms & Phenotypes for Osmotic Diarrhea

UMLS symptoms related to Osmotic Diarrhea:


diarrhea

Drugs & Therapeutics for Osmotic Diarrhea

Drugs for Osmotic Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teduglutide Approved Phase 2 197922-42-2
2
Budesonide Approved Phase 2 51333-22-3 5281004 63006
3
Glucosamine Approved, Investigational Phase 2 3416-24-8 439213
4 Protective Agents Phase 2
5 Hormone Antagonists Phase 2
6 Peripheral Nervous System Agents Phase 2
7 Autonomic Agents Phase 2
8 Anti-Asthmatic Agents Phase 2
9 Anti-Inflammatory Agents Phase 2
10 Radiation-Protective Agents Phase 2
11 glucocorticoids Phase 2
12 Respiratory System Agents Phase 2
13 Gastrointestinal Agents Phase 2
14 Bronchodilator Agents Phase 2
15 Hormones Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Cola Not Applicable
18 Cathartics Not Applicable
19 Laxatives Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reformulated F75 Milk to Treat Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
2 Therapeutic Approaches to Malnutrition Enteropathy Not yet recruiting NCT03716115 Phase 2 N-Acetyl Glucosamine (GInNAC);Teduglutide;Budesonide
3 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971 Not Applicable
4 Stability of the Microbiome in IBD and IBS Recruiting NCT03395548 Not Applicable Macrogol
5 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297

Search NIH Clinical Center for Osmotic Diarrhea

Genetic Tests for Osmotic Diarrhea

Anatomical Context for Osmotic Diarrhea

MalaCards organs/tissues related to Osmotic Diarrhea:

42
Colon, Small Intestine

Publications for Osmotic Diarrhea

Articles related to Osmotic Diarrhea:

(show all 12)
# Title Authors Year
1
Alterations in the colonic microbiota in response to osmotic diarrhea. ( 23409050 )
2013
2
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects. ( 18797153 )
2008
3
Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. ( 17171792 )
2006
4
Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. ( 11677212 )
2001
5
Oral rehydration solutions: increased water and sodium absorption by addition of a viscosity-enhancing agent in a rat model of chronic osmotic diarrhea. ( 7876995 )
1994
6
Zinc absorption in experimental osmotic diarrhea: effect of long-chain fatty acids. ( 8400847 )
1993
7
Osmotic diarrhea induced by sugar-free theophylline solution in critically ill patients. ( 1907685 )
1991
8
Improved water and sodium absorption from oral rehydration solutions based on rice syrup in a rat model of osmotic diarrhea. ( 2007957 )
1991
9
Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. ( 2794043 )
1989
10
Oral hydration solutions in experimental osmotic diarrhea: enhancement by alanine and other amino acids and oligopeptides. ( 3389333 )
1988
11
The differentiation of osmotic diarrhea from shigellosis. ( 1263492 )
1976
12
Osmotic diarrhea due to high sodium chloride intake following subtotal resection to the small intestine. ( 5435237 )
1970

Variations for Osmotic Diarrhea

Expression for Osmotic Diarrhea

Search GEO for disease gene expression data for Osmotic Diarrhea.

Pathways for Osmotic Diarrhea

Pathways related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 SLC26A3 SLC5A1
2 10.27 LCT SLC5A1

GO Terms for Osmotic Diarrhea

Cellular components related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.13 LCT SLC26A3 SLC5A1
2 apical plasma membrane GO:0016324 8.8 LCT SLC26A3 STXBP2

Sources for Osmotic Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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