OPLL
MCID: OSS014
MIFTS: 48

Ossification of the Posterior Longitudinal Ligament of Spine (OPLL)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ossification of the Posterior Longitudinal Ligament of Spine

MalaCards integrated aliases for Ossification of the Posterior Longitudinal Ligament of Spine:

Name: Ossification of the Posterior Longitudinal Ligament of Spine 57 12 36 15 71
Ossification of the Posterior Longitudinal Ligament of the Spine 20 73 29 17
Opll 57 12 20 73
Ossification of Posterior Longitudinal Ligament of Spine 13
Ossification, Posterior Longitudinal Ligament Spine 39
Ossification of Posterior Longitudinal Ligament 44

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal recessive

Miscellaneous:
common in japan and other asian populations
four types of opll - segmental (39%), continuous (27%), mixed (29%), other (5%)
high incidence of diabetes mellitus noted in opll patients


HPO:

31
ossification of the posterior longitudinal ligament of spine:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0060887
OMIM® 57 602475
KEGG 36 H00431
MeSH 44 D017887
MedGen 41 C1865343
UMLS 71 C1865343

Summaries for Ossification of the Posterior Longitudinal Ligament of Spine

GARD : 20 Ossification of the posterior longitudinal ligament of the spine (OPLL) is a condition that is characterized by the calcification of the soft tissues that connect the bones of the spine, which may lead to compression of the spinal cord. Many affected people do not have any signs or symptoms, while others may experience mild pain or numbness in the arms and/or legs. In some cases, OPLL may be associated with other conditions such as genetic diseases (i.e. hypophosphatemic rickets), endocrine disorders (i.e. acromegaly, hypoparathyroidism), spondyloarthropathies (i.e. ankylosing spondylitis), and diffuse idiopathic skeletal hyperostosis. OPLL is most commonly diagnosed in men, people of Asian descent and people over age 50. The exact underlying cause is currently unknown; however, scientists suspect that it is a multifactorial condition that is influenced by several different genetic and environmental factors. The treatment of OPLL depends the severity of the condition and the signs and symptoms present in each person. If more conservative treatments such as NSAIDs are not effective, surgery may be necessary.

MalaCards based summary : Ossification of the Posterior Longitudinal Ligament of Spine, also known as ossification of the posterior longitudinal ligament of the spine, is related to bone resorption disease and osseous heteroplasia, progressive. An important gene associated with Ossification of the Posterior Longitudinal Ligament of Spine is ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1), and among its related pathways/superpathways are TGF-beta signaling pathway and Phospholipase-C Pathway. Affiliated tissues include spinal cord, bone and skin, and related phenotypes are hyperreflexia and diabetes mellitus

Disease Ontology : 12 A connective tissue disease characterized by ectopic ossification of the posterior longitudinal spinal ligament resulting in spinal cord compression, myelopathy and hyperreflexia.

OMIM® : 57 Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common degenerative spinal disorder that causes severe neurologic dysfunction in middle-aged and elderly populations. This ectopic ossification results in compression of the spinal cord and nerve root by the ossified ligament. Histologic studies of OPLL suggest that OPLL develops through a process of endochondral ossification (summary by Nakajima et al., 2016). (602475) (Updated 05-Mar-2021)

KEGG : 36 Ossification of the posterior longitudinal ligament of spine (OPLL) is an osteogenetic disorder of the spine found among Japanese and other East Asian populations. Ectopic bone formation in the posterior longitudinal ligaments causes myelopathy in patients with OPLL. Genetic linkage studies revealed genes encoding collagens, nucleotide pyrophosphatase, and TGF-beta3 in association with susceptibility to the disease.

UniProtKB/Swiss-Prot : 73 Ossification of the posterior longitudinal ligament of the spine: A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. Patients with OPLL frequently present with a severe myelopathy that can lead to tetraparesis.

Related Diseases for Ossification of the Posterior Longitudinal Ligament of Spine

Diseases related to Ossification of the Posterior Longitudinal Ligament of Spine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 bone resorption disease 30.0 RUNX2 BMP2 BGLAP
2 osseous heteroplasia, progressive 29.0 RUNX2 ENPP1 BMP4 BMP2 BGLAP
3 diffuse idiopathic skeletal hyperostosis 28.8 STK38L RSPO2 ENPP1 COL6A1 COL11A2 CCDC91
4 body mass index quantitative trait locus 1 10.5
5 atherosclerosis susceptibility 10.3
6 arterial calcification, generalized, of infancy, 1 10.3
7 insulin-like growth factor i 10.3
8 leptin deficiency or dysfunction 10.3
9 osteomalacia 10.3
10 rickets 10.3
11 hypoparathyroidism 10.3
12 keratomalacia 10.3
13 myopathy 10.3
14 hypophosphatemic rickets, x-linked recessive 10.3
15 motor neuron disease 10.3
16 paraplegia 10.3
17 osteoporosis 10.3
18 bone mineral density quantitative trait locus 8 10.3
19 bone mineral density quantitative trait locus 15 10.3
20 spondylosis 10.1
21 spinal cord injury 10.1
22 carpal tunnel syndrome 10.1
23 hypophosphatemic rickets, autosomal dominant 10.1
24 arachnoid cysts, intracranial 10.1
25 hypophosphatemic rickets, autosomal recessive, 1 10.1
26 yemenite deaf-blind hypopigmentation syndrome 10.1
27 hypophosphatemic rickets, autosomal recessive, 2 10.1
28 arterial calcification of infancy 10.1
29 autosomal recessive hypophosphatemic rickets 10.1
30 scoliosis 10.1
31 spastic quadriplegia 10.1
32 dilated cardiomyopathy 10.1
33 uveitis 10.1
34 polyneuropathy 10.1
35 iritis 10.1
36 rectum cancer 10.1
37 enthesopathy 10.1
38 chronic inflammatory demyelinating polyradiculoneuropathy 10.1
39 demyelinating polyneuropathy 10.1
40 nerve compression syndrome 10.1
41 brown-sequard syndrome 10.1
42 cerebrovascular disease 10.1
43 degenerative disc disease 10.1
44 iridocyclitis 10.1
45 48,xyyy 10.1
46 atlanto-axial fusion 10.1
47 cerebrospinal fluid leak 10.1
48 back pain 10.1
49 dental pulp necrosis 10.1 BMP2 BGLAP
50 spondylosis, cervical 10.1

Graphical network of the top 20 diseases related to Ossification of the Posterior Longitudinal Ligament of Spine:



Diseases related to Ossification of the Posterior Longitudinal Ligament of Spine

Symptoms & Phenotypes for Ossification of the Posterior Longitudinal Ligament of Spine

Human phenotypes related to Ossification of the Posterior Longitudinal Ligament of Spine:

31 (show all 7)
# Description HPO Frequency HPO Source Accession
1 hyperreflexia 31 HP:0001347
2 diabetes mellitus 31 HP:0000819
3 increased bone mineral density 31 HP:0011001
4 abnormality of the vertebral column 31 HP:0000925
5 spinal cord compression 31 HP:0002176
6 myelopathy 31 HP:0002196
7 ectopic ossification 31 HP:0011986

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Neurologic Central Nervous System:
hyperreflexia
spinal cord compression
myelopathy

Skeletal Spine:
ectopic ossification of posterior longitudinal spinal ligament (cervical and thoracic spine)

Skeletal:
increased bone mineral density

Clinical features from OMIM®:

602475 (Updated 05-Mar-2021)

MGI Mouse Phenotypes related to Ossification of the Posterior Longitudinal Ligament of Spine:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.5 BMP2 BMP4 COL11A2 ENPP1 RSPH9 RSPO2
2 skeleton MP:0005390 9.32 BGLAP BMP2 BMP4 COL11A2 COL6A1 ENPP1

Drugs & Therapeutics for Ossification of the Posterior Longitudinal Ligament of Spine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
2 Evaluation of Safety and Efficency of Custom-made Corpectomy Implants: UNiD 3D VBR Unknown status NCT02926391
3 Long Term Follow-Up of Post Neck Pain Patients Accompanying Ossification of Posterior Longitudinal Ligament Treated With Integrated Complementary and Alternative Medicine: Observational Study Recruiting NCT04446221
4 Comparison of Anterior Cervical Anteriodisplacement Fusion and Corpectomy Decompression Fusion in Treatment of Ossification of the Posterior Longitudinal Ligament: A Conservative Treatment- Controlled, Randomized, Open Label Clinical Study Active, not recruiting NCT03312985
5 Comparison of Anterior Cervical Anteriodisplacement Fusion and Corpectomy Decompression Fusion in Treatment of Ossification of the Posterior Longitudinal Ligament: A Multi-center,Controlled, Randomized, Open Label Clinical Study Active, not recruiting NCT03591692

Search NIH Clinical Center for Ossification of the Posterior Longitudinal Ligament of Spine

Cochrane evidence based reviews: ossification of posterior longitudinal ligament

Genetic Tests for Ossification of the Posterior Longitudinal Ligament of Spine

Genetic tests related to Ossification of the Posterior Longitudinal Ligament of Spine:

# Genetic test Affiliating Genes
1 Ossification of the Posterior Longitudinal Ligament of the Spine 29

Anatomical Context for Ossification of the Posterior Longitudinal Ligament of Spine

MalaCards organs/tissues related to Ossification of the Posterior Longitudinal Ligament of Spine:

40
Spinal Cord, Bone, Skin, Bone Marrow, Medulla Oblongata, Small Intestine

Publications for Ossification of the Posterior Longitudinal Ligament of Spine

Articles related to Ossification of the Posterior Longitudinal Ligament of Spine:

(show top 50) (show all 1112)
# Title Authors PMID Year
1
Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine. 61 57
27374772 2016
2
Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes. 57 61
27246988 2016
3
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. 57 61
25064007 2014
4
A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. 61 57
16609882 2006
5
Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. 57 61
12958705 2003
6
Gender-specific haplotype association of collagen alpha2 (XI) gene in ossification of the posterior longitudinal ligament of the spine. 61 57
11289713 2001
7
Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). 61 57
10453738 1999
8
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. 61 57
9662402 1998
9
Genetic mapping of ossification of the posterior longitudinal ligament of the spine. 57 61
9585596 1998
10
Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL). 61 57
9457678 1998
11
Genetic studies on ossification of the posterior longitudinal ligament of the spine. 57 61
2513651 1989
12
A radiological population study on the ossification of the posterior longitudinal ligament in the spine. 61 57
3494437 1987
13
Ossification of the posterior longitudinal ligament of the spine. 57 61
6423334 1984
14
Calcification and ossification of posterior longitudinal ligament of spine: its role in secondary narrowing of spinal canal and cord compression. 57
6813778 1982
15
Prediction of angular kyphosis after cervical laminoplasty using radiologic measurements. 61
33581783 2021
16
Efficacy and Safety of Ultrasonic Bone Curette-assisted Dome-like Laminoplasty in the Treatment of Cervical Ossification of Longitudinal Ligament. 61
33403818 2021
17
Microsurgical Anterior Controllable Antedisplacement Fusion to Treat Cervical Ossified Posterior Longitudinal Ligament: 2-Dimensional Operative Video. 61
33372965 2021
18
Fate of Ossification of Posterior Longitudinal Ligament Following Anterior Cervical Fusion: Progression of Cervical Ossification of Posterior Longitudinal Ligament After Vertebral Body Sliding Osteotomy or Laminoplasty. 61
33276178 2021
19
K-line in patients with cervical ossification of the posterior longitudinal ligament: relationship with change in sagittal cervical curvature and laminoplasty outcomes. 61
33555403 2021
20
Motor-evoked potentials in the intraoperative decision-making of circumferential decompression via posterior approach for treating thoracic posterior longitudinal ligament ossification. 61
33545375 2021
21
Exclusion of Ossified Ligaments Behind C2 Vertebra Combined with Anterior Controllable Antedisplacement and Fusion for Cervical Ossification of the Posterior Longitudinal Ligament Extending to C2 Segment. 61
33307264 2021
22
Epidemiology of Spinal Cord Injury: Changes to Its Cause Amid Aging Population, a Single Center Study. 61
33557481 2021
23
What Is the Impact of Surgical Approach in the Treatment of Degenerative Cervical Myelopathy in Patients With OPLL? A Propensity-Score Matched, Multi-Center Analysis on Inpatient and Post-Discharge 90-Day Outcomes. 61
33601898 2021
24
Ossification of Posterior Longitudinal Ligament in Cervical Spine and Its Association With Ossified Lesions in the Whole Spine: A Cross-Sectional Study of 2500 CT Scans. 61
33567929 2021
25
How much space of the spinal canal should be restored by hoisting the vertebrae-OPLL complex for sufficient decompression in anterior controllable antedisplacement and fusion? A multicenter clinical radiological study. 61
32966909 2021
26
Efficacy of Intraoperative Intervention Following Transcranial Motor-evoked Potentials Alert During Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study of the Monitoring Committee of the Japanese Society for Spine Surgery and Related Research. 61
33156280 2021
27
Novel Simultaneous Decompression Through Single-stage Mini-thoracotomy for Concurrent Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum at the Same Thoracic Level: A Technical Report and Literature Review. 61
33079907 2021
28
Retrospective comparison of the surgical results for patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament: Posterior decompression with instrumented spinal fusion versus modified anterior decompression through a posterior approach. 61
33568316 2021
29
Intraoperative evoked potentials in patients with ossification of posterior longitudinal ligament. 61
33548015 2021
30
Review of laminoplasty versus laminectomy in the surgical management of cervical spondylotic myelopathy. 61
33598360 2021
31
Unplanned hospital readmission after surgical treatment for thoracic spinal stenosis: incidence and causative factors. 61
33472615 2021
32
Comparative Effectiveness and Safety of Anterior Cervical Corpectomy with Fusion, Laminoplasty, and Laminectomy and Instrumented Fusion for Ossification of the Posterior Longitudinal Ligament: A Systematic Review and Network Meta-Analysis. 61
33472478 2021
33
Cervical Spondylotic Myelopathy with Ossification of Posterior Longitudinal Ligament: Which Is the Most Suitable Surgical Procedure? A Technical Note. 61
33575494 2021
34
Does surgical treatment increase the progression of spinal cord injury in patients with ossification of posterior longitudinal ligament of cervical spine? A systematic review and meta-analysis. 61
33410375 2021
35
Risk factors for rapid progressive neurological deterioration in patients with cervical spondylotic myelopathy. 61
33478509 2021
36
Surgical Options in Treating Ossification of the Posterior Longitudinal Ligament: Single-Center Experience. 61
33482410 2021
37
A New Classification for Cervical Ossification of the Posterior Longitudinal Ligament Based on the Coexistence of Segmental Disc Degeneration. 61
33105534 2021
38
Evaluation of cervical ossification of the posterior longitudinal ligament with 3D broadband IR-prepared ultrashort echo-time imaging: a pilot study. 61
33462729 2021
39
Risk factor analysis of surgery-related complications in primary cervical spine surgery for degenerative diseases using a surgeon-maintained database. 61
33380205 2021
40
Association Between Deep Posterior Cervical Paraspinal Muscle Morphology and Clinical Features in Patients With Cervical Ossification of the Posterior Longitudinal Ligament. 61
33504203 2021
41
Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine. 61
33487053 2021
42
Anterior Controllable Antedisplacement and Fusion (ACAF) vs Posterior Laminoplasty for Multilevel Severe Cervical Ossification of the Posterior Longitudinal Ligament: Retrospective Study Based on a Two-Year Follow-up. 61
33522136 2021
43
Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization. 61
32980560 2021
44
Exceptional Conditions for Favorable Neurological Recovery After Laminoplasty in Cases With Cervical Myelopathy Caused by K-line (-) Ossification of Posterior Longitudinal Ligament. 61
33428361 2021
45
Effect of teriparatide on ligamentum flavum mesenchymal stem cells isolated from patients with ossification of the posterior longitudinal ligament. 61
33357776 2021
46
Microsurgical Resection of Ossification of the Posterior Longitudinal Ligament in the Thoracic Spine via the Transthoracic Approach Without Spinal Fusion: 2-Dimensional Operative Video. 61
33075573 2021
47
Thin Cervical Spinal Cord Between Ossifications of the Ligamentum Flavum and the Posterior Longitudinal Ligament: Case Report and Literature Review. 61
32920158 2021
48
Influence of K-line on intraoperative and hidden blood loss in patients with ossification of the posterior longitudinal ligament when undergoing unilateral open-door laminoplasty. 61
33422106 2021
49
Arteriovenous Fistula at the Craniocervical Junction Found After Cervical Laminoplasty for Ossification of the Posterior Longitudinal Ligament. 61
33401875 2020
50
Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study. 61
33334036 2020

Variations for Ossification of the Posterior Longitudinal Ligament of Spine

UniProtKB/Swiss-Prot genetic disease variations for Ossification of the Posterior Longitudinal Ligament of Spine:

73
# Symbol AA change Variation ID SNP ID
1 ENPP1 p.Leu91Pro VAR_014141
2 ENPP1 p.Ser287Phe VAR_014143 rs190947144

Expression for Ossification of the Posterior Longitudinal Ligament of Spine

Search GEO for disease gene expression data for Ossification of the Posterior Longitudinal Ligament of Spine.

Pathways for Ossification of the Posterior Longitudinal Ligament of Spine

Pathways related to Ossification of the Posterior Longitudinal Ligament of Spine according to KEGG:

36
# Name Kegg Source Accession
1 TGF-beta signaling pathway hsa04350

Pathways related to Ossification of the Posterior Longitudinal Ligament of Spine according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 GDF2 COL6A1 COL11A2 BMP4 BMP2
2
Show member pathways
12.32 COL6A1 COL11A2 BMP4 BMP2
3 10.9 RUNX2 BMP4 BMP2 BGLAP
4 10.72 BMP4 BMP2
5 10.6 BMP4 BMP2
6 10.26 GDF2 COL6A1 COL11A2 BMP4 BMP2

GO Terms for Ossification of the Posterior Longitudinal Ligament of Spine

Cellular components related to Ossification of the Posterior Longitudinal Ligament of Spine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 RSPO2 IL15RA GDF2 ENPP1 COL6A1 COL11A2
2 endoplasmic reticulum lumen GO:0005788 9.46 COL6A1 COL11A2 BMP4 BGLAP
3 extracellular space GO:0005615 9.28 MIR10A IL15RA GDF2 ENPP1 COL6A1 COL11A2

Biological processes related to Ossification of the Posterior Longitudinal Ligament of Spine according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 RUNX2 GDF2 BMP4 BMP2
2 positive regulation of endothelial cell proliferation GO:0001938 9.77 GDF2 BMP4 BMP2
3 positive regulation of osteoblast differentiation GO:0045669 9.77 RUNX2 BMP4 BMP2
4 skeletal system development GO:0001501 9.77 RUNX2 COL11A2 BMP4 BMP2 BGLAP
5 BMP signaling pathway GO:0030509 9.76 RUNX2 GDF2 BMP4 BMP2
6 cellular response to growth factor stimulus GO:0071363 9.75 BMP4 BMP2 BGLAP
7 SMAD protein signal transduction GO:0060395 9.74 GDF2 BMP4 BMP2
8 odontogenesis of dentin-containing tooth GO:0042475 9.72 RUNX2 BMP4 BMP2
9 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.71 GDF2 BMP4 BMP2
10 cartilage development GO:0051216 9.71 GDF2 COL11A2 BMP4 BMP2
11 bone mineralization GO:0030282 9.7 RSPO2 BMP2 BGLAP
12 embryonic cranial skeleton morphogenesis GO:0048701 9.67 RUNX2 BMP4
13 embryonic forelimb morphogenesis GO:0035115 9.66 RUNX2 RSPO2
14 endochondral ossification GO:0001958 9.65 RUNX2 BMP4
15 embryonic hindlimb morphogenesis GO:0035116 9.65 RSPO2 BMP4
16 telencephalon development GO:0021537 9.65 BMP4 BMP2
17 regulation of bone mineralization GO:0030500 9.64 ENPP1 BGLAP
18 cardiac muscle cell differentiation GO:0055007 9.64 BMP4 BMP2
19 positive regulation of endothelial cell differentiation GO:0045603 9.63 GDF2 BMP4
20 epithelial tube branching involved in lung morphogenesis GO:0060441 9.63 RSPO2 BMP4
21 osteoblast development GO:0002076 9.62 RUNX2 BGLAP
22 positive regulation of ossification GO:0045778 9.62 BMP4 BMP2
23 chondrocyte differentiation GO:0002062 9.62 RUNX2 COL11A2 BMP4 BMP2
24 pathway-restricted SMAD protein phosphorylation GO:0060389 9.61 GDF2 BMP2
25 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.61 RUNX2 BMP2
26 positive regulation of cartilage development GO:0061036 9.61 GDF2 BMP4 BMP2
27 telencephalon regionalization GO:0021978 9.58 BMP4 BMP2
28 BMP signaling pathway involved in heart development GO:0061312 9.56 BMP4 BMP2
29 cellular response to BMP stimulus GO:0071773 9.56 RUNX2 GDF2 BMP4 BMP2
30 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.51 BMP4 BMP2
31 BMP signaling pathway involved in heart induction GO:0003130 9.49 BMP4 BMP2
32 cardiac jelly development GO:1905072 9.48 BMP4 BMP2
33 ossification GO:0001503 9.35 RUNX2 GDF2 BMP4 BMP2 BGLAP
34 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.33 RUNX2 BMP4 BMP2
35 osteoblast differentiation GO:0001649 9.23 RUNX2 RSPO2 GDF2 COL6A1 COL11A2 BMP4

Molecular functions related to Ossification of the Posterior Longitudinal Ligament of Spine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 GDF2 BMP4 BMP2
2 BMP receptor binding GO:0070700 8.96 BMP4 BMP2
3 co-receptor binding GO:0039706 8.62 BMP4 BMP2

Sources for Ossification of the Posterior Longitudinal Ligament of Spine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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