MCID: OSS001
MIFTS: 45

Ossifying Fibroma

Categories: Cancer diseases, Bone diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

MalaCards integrated aliases for Ossifying Fibroma:

Name: Ossifying Fibroma 12 15 73
Peripheral Ossifying Fibroma 12 73
Fibroma, Ossifying 44
Fibroma Ossifying 55
Fibro-Osteoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:180
MeSH 44 D018214
NCIt 50 C8422

Summaries for Ossifying Fibroma

Disease Ontology : 12 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary : Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. Affiliated tissues include the mouth, bone and testes, and related phenotypes are growth/size/body region and cellular

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 juvenile ossifying fibroma 34.2 MDM2 RASAL1
2 osteofibrous dysplasia 12.0
3 hyperparathyroidism 2 with jaw tumors 11.7
4 gigantiform cementoma, familial 11.3
5 encephalocraniocutaneous lipomatosis 11.1
6 sinusitis 10.5
7 fibrous dysplasia 10.5
8 aneurysmal bone cysts 10.4
9 aneurysm 10.4
10 juxtacortical osteosarcoma 10.2 GNAS MDM2
11 pyogenic granuloma 10.2
12 hyperparathyroidism 10.1
13 gingivitis 10.1
14 peripheral osteosarcoma 10.1 GNAS MDM2
15 periodontitis 10.1
16 chondrosarcoma 10.0
17 osteoblastoma 10.0
18 mastoiditis 10.0
19 monostotic fibrous dysplasia 10.0
20 richter's syndrome 9.9 ERCC6 NOTCH1
21 nodular regenerative hyperplasia 9.9 JAG1 NOTCH1
22 adamantinoma of long bones 9.8
23 cowden syndrome 1 9.8
24 neurofibromatosis, type i 9.8
25 neurofibromatosis, type iv, of riccardi 9.8
26 buschke-ollendorff syndrome 9.8
27 retinoblastoma 9.8
28 tuberous sclerosis 1 9.8
29 oculoectodermal syndrome 9.8
30 ameloblastoma 9.8
31 fanconi syndrome 9.8
32 sphenoid sinusitis 9.8
33 primary hyperparathyroidism 9.8
34 orbital cellulitis 9.8
35 chronic apical periodontitis 9.8
36 tuberous sclerosis 9.8
37 giant cell tumor 9.8
38 cellulitis 9.8
39 bilateral retinoblastoma 9.8
40 epulis 9.8
41 juxtacortical chondrosarcoma 9.8
42 adenoma 9.8
43 psammomatous meningioma 9.8
44 parathyroid adenoma 9.8
45 hyperthyroidism 9.8
46 exophthalmos 9.8
47 periostitis 9.8
48 fibromatosis 9.8
49 fibromatosis multiple non ossifying 9.8
50 florid cemento-osseous dysplasia 9.8

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 GNAS JAG2 NOTCH1 ERCC6 JAG1 MDM2
2 cellular MP:0005384 10.13 CDC73 GNAS ERCC6 JAG1 MDM2 NOTCH3
3 hematopoietic system MP:0005397 10.11 NOTCH1 ERCC6 JAG1 MDM2 CDC73 GNAS
4 homeostasis/metabolism MP:0005376 10.1 GNAS JAG2 ERCC6 JAG1 MDM2 CDC73
5 endocrine/exocrine gland MP:0005379 10.09 JAG2 NOTCH1 JAG1 MDM2 CDC73 GNAS
6 cardiovascular system MP:0005385 10.07 CDC73 GNAS JAG1 MDM2 NOTCH3 NOTCH1
7 integument MP:0010771 10.06 NOTCH1 ERCC6 JAG1 MDM2 CDC73 GNAS
8 craniofacial MP:0005382 10.05 JAG2 NOTCH1 JAG1 MDM2 CDC73 GNAS
9 embryo MP:0005380 10.03 JAG2 NOTCH1 JAG1 MDM2 CDC73 NOTCH3
10 immune system MP:0005387 10.02 GNAS JAG2 ERCC6 MDM2 CDC73 NOTCH3
11 mortality/aging MP:0010768 10.01 GNAS JAG2 ERCC6 JAG1 MDM2 CDC73
12 hearing/vestibular/ear MP:0005377 10 NOTCH1 ERCC6 JAG1 GNAS JAG2 NOTCH3
13 digestive/alimentary MP:0005381 9.97 CDC73 JAG2 JAG1 MDM2 NOTCH1
14 liver/biliary system MP:0005370 9.91 NOTCH1 ERCC6 JAG1 MDM2 CDC73 GNAS
15 muscle MP:0005369 9.91 NOTCH1 ERCC6 JAG1 MDM2 CDC73 GNAS
16 nervous system MP:0003631 9.86 JAG2 NOTCH1 ERCC6 JAG1 MDM2 CDC73
17 neoplasm MP:0002006 9.8 NOTCH1 ERCC6 MDM2 CDC73 GNAS NOTCH3
18 renal/urinary system MP:0005367 9.63 NOTCH1 JAG1 MDM2 CDC73 GNAS NOTCH3
19 respiratory system MP:0005388 9.35 CDC73 GNAS JAG2 NOTCH3 NOTCH1
20 skeleton MP:0005390 9.23 NOTCH1 ERCC6 JAG1 MDM2 CDC73 GNAS

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

The Foundational Model of Anatomy Ontology organs/tissues related to Ossifying Fibroma:

19
The Mouth

MalaCards organs/tissues related to Ossifying Fibroma:

41
Bone, Testes, Bone Marrow

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 630)
# Title Authors Year
1
Juvenile Trabecular Ossifying Fibroma-a Case Report. ( 29887713 )
2018
2
Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma. ( 28991228 )
2018
3
Rare case of a recurrent juvenile ossifying fibroma of the lumbosacral spine. ( 29521580 )
2018
4
Juvenile Ossifying Fibroma in the Mandible. ( 29963444 )
2018
5
CT and MR imaging characteristics of histological subtypes of head and neck ossifying fibroma. ( 29595323 )
2018
6
A Case of Juvenile Psammomatoid Ossifying Fibroma on Skull Base. ( 29762329 )
2018
7
MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma. ( 29032608 )
2018
8
The aetiology of the non-ossifying fibroma of the distal femur and its relationship to the surrounding soft tissues. ( 29081852 )
2017
9
Giant Peripheral Ossifying Fibroma of the Posterior Mandible-A Rare Case Report. ( 29563937 )
2017
10
Juvenile psammomatoid ossifying fibroma in paranasal sinus and skull base. ( 28125310 )
2017
11
Psammomatoid Juvenile Ossifying Fibroma of Mandible in a 41-Year Male Patient. ( 28292370 )
2017
12
Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. ( 28642188 )
2017
13
Trabecular Variant: A Rare Entity of Juvenile Ossifying Fibroma of the Mandible. ( 28566876 )
2017
14
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2017
15
Conservative Management of Central Cemento-Ossifying Fibroma. ( 27831973 )
2017
16
Ossifying fibroma of the maxilla and sinonasal tract: Case series. ( 28381325 )
2017
17
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. ( 28479709 )
2017
18
Idiopathic peripheral ossifying fibroma in a young adolescent girl: A very rare clinical presentation. ( 29456309 )
2017
19
Trabecular Variant Juvenile Ossifying Fibroma of the Maxilla. ( 29152441 )
2017
20
Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma: A preliminary study. ( 28195085 )
2017
21
Clinicopathological Characteristics and Prognosis of Ossifying Fibroma in the Jaws of Children: A Retrospective Study. ( 29151945 )
2017
22
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. ( 27922957 )
2017
23
Cemento-ossifying fibroma of the mandible. A clinicopathological report. ( 28439606 )
2017
24
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. ( 29184270 )
2017
25
Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report. ( 28402358 )
2017
26
Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review. ( 28467645 )
2017
27
A large psammomatoid ossifying fibroma with proptosis: A case report. ( 28357086 )
2017
28
Psammomatoid Juvenile Ossifying Fibroma: Report of Three Cases with a Review of Literature. ( 29675079 )
2017
29
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity. ( 28932332 )
2017
30
Juvenile Trabecular Ossifying Fibroma. ( 29027609 )
2017
31
Pediatric cemento-ossifying fibroma of the orbital roof: Rare pathology at a rare location. ( 28681781 )
2017
32
Ossifying fibroma: an uncommon differential diagnosis for T2-hypointense sinonasal masses. ( 28491178 )
2017
33
The role of Osterix protein in the pathogenesis of peripheral ossifying fibroma. ( 28678972 )
2017
34
Osteofibrous Dysplasia Versus Ossifying Fibroma: Semantic Confusion. ( 28238823 )
2017
35
Peripheral osteoma, compound odontoma, focal cemento-osseous dysplasia, and cemento-ossifying fibroma in the same hemimandible: CBCT findings of an unusual case. ( 29484064 )
2017
36
Aggressive ossifying fibroma of right ethmoidal sinus: A case report. ( 29373206 )
2017
37
940 nm Diode Laser assisted excision of Peripheral Ossifying Fibroma in a neonate. ( 28740329 )
2017
38
Conglomeration of Trabecular and Psammomatoid variants of juvenile ossifying fibroma - a rare case report. ( 28588818 )
2017
39
Peripheral ossifying fibroma: A rare case affecting maxillary region. ( 27795650 )
2016
40
Juvenile Trabecular Ossifying Fibroma of the Maxilla: a Case Report. ( 28210024 )
2016
41
Case of the Month: Peripheral Ossifying Fibroma. ( 27476233 )
2016
42
Ossifying fibroma: report on a clinical case, with the imaging and histopathological diagnosis made and treatment administered. ( 26962494 )
2016
43
Reply to the "Letter to the Editor" commenting on the article "An Update of Peripheral Ossifying Fibroma: Case Report and Literature Review". ( 27888362 )
2016
44
CDC73 gene mutations in sporadic ossifying fibroma of the jaws. ( 27658992 )
2016
45
Juvenile Psammomatoid Ossifying Fibroma: Findings on Bone Scan. ( 27405032 )
2016
46
Juvenile psammomatoid ossifying fibroma of the posterior fossa: a case report and review. ( 27468389 )
2016
47
Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma. ( 28101383 )
2016
48
OCULOECTODERMAL SYNDROME: A NEW CASE WITH GIANT CELL GRANULOMAS AND NON-OSSIFYING FIBROMAS. ( 27192894 )
2016
49
Oral Pathology. Common Oral Gingival Lesions. Diagnosis: Peripheral ossifying fibroma. ( 27263144 )
2016
50
Cranial juvenile psammomatoid ossifying fibroma: case report. ( 26588460 )
2016

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
2
Show member pathways
13.42 JAG1 JAG2 MDM2 NOTCH1 NOTCH3 RASAL1
3
Show member pathways
12.66 GNAS JAG1 MDM2 NOTCH1 NOTCH3
4
Show member pathways
12.61 JAG1 JAG2 NOTCH1 NOTCH3
5
Show member pathways
12.48 JAG1 JAG2 NOTCH1 NOTCH3
6 12.45 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
7
Show member pathways
12.32 JAG1 JAG2 NOTCH1 NOTCH3
8
Show member pathways
12.3 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
9 12.24 MDM2 NOTCH1 NOTCH3
10
Show member pathways
12.13 JAG1 JAG2 NOTCH1 NOTCH3
11
Show member pathways
11.96 JAG1 JAG2 NOTCH1
12
Show member pathways
11.85 JAG1 JAG2 NOTCH1
13 11.74 MDM2 NOTCH1 NOTCH3
14 11.61 CDC73 JAG1 JAG2 NOTCH1 NOTCH3
15 11.58 JAG1 NOTCH1 NOTCH3
16 11.21 JAG1 JAG2 NOTCH1
17 10.77 JAG1 NOTCH1
18 10.75 JAG1 JAG2 NOTCH1
19 10.36 JAG1 JAG2 NOTCH1 NOTCH3

GO Terms for Ossifying Fibroma

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 GNAS JAG1 NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 CDC73 MDM2 NOTCH1 NOTCH3
2 regulation of cell proliferation GO:0042127 9.78 JAG1 JAG2 NOTCH1
3 positive regulation of osteoblast differentiation GO:0045669 9.63 GNAS JAG1
4 negative regulation of cell differentiation GO:0045596 9.63 JAG1 NOTCH1 NOTCH3
5 cell communication GO:0007154 9.62 JAG1 JAG2
6 protein destabilization GO:0031648 9.62 CDC73 MDM2
7 negative regulation of neuron differentiation GO:0045665 9.61 JAG1 NOTCH1 NOTCH3
8 blood vessel remodeling GO:0001974 9.6 JAG1 MDM2
9 embryonic hindlimb morphogenesis GO:0035116 9.59 GNAS NOTCH1
10 neuron fate commitment GO:0048663 9.58 NOTCH1 NOTCH3
11 neuronal stem cell population maintenance GO:0097150 9.58 JAG1 NOTCH1
12 positive regulation of transcription of Notch receptor target GO:0007221 9.57 NOTCH1 NOTCH3
13 endocardial cushion morphogenesis GO:0003203 9.56 MDM2 NOTCH1
14 Notch receptor processing GO:0007220 9.55 JAG1 JAG2
15 negative regulation of stem cell differentiation GO:2000737 9.54 JAG1 NOTCH1
16 positive regulation of Notch signaling pathway GO:0045747 9.54 JAG1 JAG2 NOTCH1
17 response to muramyl dipeptide GO:0032495 9.52 JAG1 NOTCH1
18 atrioventricular valve morphogenesis GO:0003181 9.51 MDM2 NOTCH1
19 pulmonary valve morphogenesis GO:0003184 9.49 JAG1 NOTCH1
20 Notch signaling involved in heart development GO:0061314 9.48 JAG1 NOTCH1
21 Notch signaling pathway GO:0007219 9.46 JAG1 JAG2 NOTCH1 NOTCH3
22 regulation of developmental process GO:0050793 9.4 NOTCH1 NOTCH3
23 auditory receptor cell fate commitment GO:0009912 9.32 JAG2 NOTCH1
24 distal tubule development GO:0072017 9.26 JAG1 NOTCH1
25 Notch receptor processing, ligand-dependent GO:0035333 9.13 JAG1 JAG2 NOTCH3
26 cardiac septum morphogenesis GO:0060411 8.8 JAG1 MDM2 NOTCH1

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 JAG1 JAG2 NOTCH1 NOTCH3
2 Notch binding GO:0005112 8.8 JAG1 JAG2 NOTCH1

Sources for Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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