MCID: OSS001
MIFTS: 46

Ossifying Fibroma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

MalaCards integrated aliases for Ossifying Fibroma:

Name: Ossifying Fibroma 12 15 73
Peripheral Ossifying Fibroma 12 73
Fibroma, Ossifying 44
Fibroma Ossifying 55
Fibro-Osteoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:180
MeSH 44 D018214
NCIt 50 C8422
SNOMED-CT 68 25603007 80699009

Summaries for Ossifying Fibroma

Disease Ontology : 12 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary : Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. Affiliated tissues include bone, testes and eye, and related phenotypes are growth/size/body region and cellular

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 juvenile ossifying fibroma 34.2 MDM2 RASAL1
2 osteofibrous dysplasia 12.2
3 hyperparathyroidism 2 with jaw tumors 11.5
4 gigantiform cementoma, familial 11.5
5 encephalocraniocutaneous lipomatosis 11.3
6 fibrous dysplasia 10.7
7 pyogenic granuloma 10.3
8 hyperparathyroidism 10.2
9 exophthalmos 10.2
10 neurofibromatosis, type i 10.1
11 chondrosarcoma 10.1
12 aneurysmal bone cysts 10.1
13 osteoblastoma 10.1
14 florid cemento-osseous dysplasia 10.1
15 monostotic fibrous dysplasia 10.1
16 juxtacortical osteosarcoma 10.1 GNAS MDM2
17 peripheral osteosarcoma 10.0 GNAS MDM2
18 buschke-ollendorff syndrome 10.0
19 retinoblastoma 10.0
20 tuberous sclerosis 1 10.0
21 oculoectodermal syndrome 10.0
22 sinusitis 10.0
23 ameloblastoma 10.0
24 osteomalacia 10.0
25 fanconi syndrome 10.0
26 sarcoma 10.0
27 primary hyperparathyroidism 10.0
28 orbital cellulitis 10.0
29 chronic apical periodontitis 10.0
30 tuberous sclerosis 10.0
31 giant cell tumor 10.0
32 cellulitis 10.0
33 spindle cell sarcoma 10.0
34 bilateral retinoblastoma 10.0
35 epulis 10.0
36 juxtacortical chondrosarcoma 10.0
37 adenoma 10.0
38 parathyroid adenoma 10.0
39 hyperthyroidism 10.0
40 periapical periodontitis 10.0
41 periodontitis 10.0
42 trichorhinophalangeal syndrome 10.0
43 degos 'en cocarde' erythrokeratoderma 10.0
44 fibromatosis 10.0
45 fibromatosis multiple non ossifying 10.0
46 lipoblastoma 10.0
47 odontoma 10.0
48 keratocystic odontogenic tumor 10.0
49 cell type benign neoplasm 9.9 CDC73 GNAS
50 chorioretinal scar 9.9 NOTCH1 NOTCH3

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
2 cellular MP:0005384 10.13 CDC73 ERCC6 GNAS JAG1 MDM2 NOTCH1
3 hematopoietic system MP:0005397 10.11 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
4 homeostasis/metabolism MP:0005376 10.1 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
5 endocrine/exocrine gland MP:0005379 10.09 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
6 cardiovascular system MP:0005385 10.07 CDC73 GNAS JAG1 MDM2 NOTCH1 NOTCH3
7 integument MP:0010771 10.06 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
8 craniofacial MP:0005382 10.05 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
9 embryo MP:0005380 10.03 CDC73 JAG1 JAG2 MDM2 NOTCH1 NOTCH3
10 immune system MP:0005387 10.02 CDC73 ERCC6 GNAS JAG2 MDM2 NOTCH1
11 mortality/aging MP:0010768 10.01 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
12 hearing/vestibular/ear MP:0005377 10 ERCC6 GNAS JAG1 JAG2 NOTCH1 NOTCH3
13 digestive/alimentary MP:0005381 9.97 CDC73 JAG1 JAG2 MDM2 NOTCH1
14 liver/biliary system MP:0005370 9.91 CDC73 ERCC6 GNAS JAG1 MDM2 NOTCH1
15 muscle MP:0005369 9.91 CDC73 ERCC6 GNAS JAG1 MDM2 NOTCH1
16 nervous system MP:0003631 9.86 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
17 neoplasm MP:0002006 9.8 CDC73 ERCC6 GNAS MDM2 NOTCH1 NOTCH3
18 renal/urinary system MP:0005367 9.63 CDC73 GNAS JAG1 MDM2 NOTCH1 NOTCH3
19 respiratory system MP:0005388 9.35 CDC73 GNAS JAG2 NOTCH1 NOTCH3
20 skeleton MP:0005390 9.23 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

MalaCards organs/tissues related to Ossifying Fibroma:

41
Bone, Testes, Eye, Bone Marrow, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Ossifying Fibroma:

19
The Mouth

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 686)
# Title Authors Year
1
Juvenile Trabecular Ossifying Fibroma-a Case Report. ( 29887713 )
2018
2
Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma. ( 28991228 )
2018
3
Rare case of a recurrent juvenile ossifying fibroma of the lumbosacral spine. ( 29521580 )
2018
4
Juvenile Ossifying Fibroma in the Mandible. ( 29963444 )
2018
5
CT and MR imaging characteristics of histological subtypes of head and neck ossifying fibroma. ( 29595323 )
2018
6
A Case of Juvenile Psammomatoid Ossifying Fibroma on Skull Base. ( 29762329 )
2018
7
MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma. ( 29032608 )
2018
8
Corrigendum to "Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma". ( 29992060 )
2018
9
Psammomatoid variant of juvenile ossifying fibroma. ( 30004078 )
2018
10
Microvessel density and cell proliferation in juvenile ossifying fibroma: A comparative study with central ossifying fibroma. ( 30098514 )
2018
11
Management of an extensive equine juvenile ossifying fibroma by rostral mandibulectomy and reconstruction of the mandibular symphysis using String of Pearls plates with cortical and cancellous bone autografts. ( 30370537 )
2018
12
Non-ossifying fibroma of the right clavicle. ( 30027926 )
2018
13
Recurrent benign ossifying fibroma of the orbit - clinical, radiological profile and management options in a child. ( 30089218 )
2018
14
Recurrent juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of the maxilla: a case report and review of literature. ( 30090219 )
2018
15
An Immature Ten-year Long-standing Case of Ossifying Fibroma. ( 30112258 )
2018
16
Recurrent peripheral ossifying fibroma: Case report. ( 30152640 )
2018
17
Surgical correction of residual facial deformity following conservative excision of a giant maxillary ossifying fibroma: A case report. ( 30461617 )
2018
18
CLINICAL REASONING IN THE FACE OF UNCERTAINTY: CONSERVATIVE PHYSICAL THERAPY MANAGEMENT OF A TEENAGE ATHLETE DIAGNOSED WITH A PROXIMAL HUMERAL NON-OSSIFYING FIBROMA. ( 30534470 )
2018
19
Non-ossifying fibroma with a pathologic fracture in a 12-year-old girl with tricho-rhino-phalangeal syndrome: a case report. ( 30541476 )
2018
20
Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone. ( 30549028 )
2018
21
The aetiology of the non-ossifying fibroma of the distal femur and its relationship to the surrounding soft tissues. ( 29081852 )
2017
22
Giant Peripheral Ossifying Fibroma of the Posterior Mandible-A Rare Case Report. ( 29563937 )
2017
23
Juvenile psammomatoid ossifying fibroma in paranasal sinus and skull base. ( 28125310 )
2017
24
Psammomatoid Juvenile Ossifying Fibroma of Mandible in a 41-Year Male Patient. ( 28292370 )
2017
25
Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. ( 28642188 )
2017
26
Trabecular Variant: A Rare Entity of Juvenile Ossifying Fibroma of the Mandible. ( 28566876 )
2017
27
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2017
28
Conservative Management of Central Cemento-Ossifying Fibroma. ( 27831973 )
2017
29
Ossifying fibroma of the maxilla and sinonasal tract: Case series. ( 28381325 )
2017
30
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. ( 28479709 )
2017
31
Idiopathic peripheral ossifying fibroma in a young adolescent girl: A very rare clinical presentation. ( 29456309 )
2017
32
Trabecular Variant Juvenile Ossifying Fibroma of the Maxilla. ( 29152441 )
2017
33
Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma: A preliminary study. ( 28195085 )
2017
34
Clinicopathological Characteristics and Prognosis of Ossifying Fibroma in the Jaws of Children: A Retrospective Study. ( 29151945 )
2017
35
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. ( 27922957 )
2017
36
Cemento-ossifying fibroma of the mandible. A clinicopathological report. ( 28439606 )
2017
37
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. ( 29184270 )
2017
38
Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report. ( 28402358 )
2017
39
Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review. ( 28467645 )
2017
40
A large psammomatoid ossifying fibroma with proptosis: A case report. ( 28357086 )
2017
41
Psammomatoid Juvenile Ossifying Fibroma: Report of Three Cases with a Review of Literature. ( 29675079 )
2017
42
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity. ( 28932332 )
2017
43
Juvenile Trabecular Ossifying Fibroma. ( 29027609 )
2017
44
Pediatric cemento-ossifying fibroma of the orbital roof: Rare pathology at a rare location. ( 28681781 )
2017
45
Ossifying fibroma: an uncommon differential diagnosis for T2-hypointense sinonasal masses. ( 28491178 )
2017
46
The role of Osterix protein in the pathogenesis of peripheral ossifying fibroma. ( 28678972 )
2017
47
Osteofibrous Dysplasia Versus Ossifying Fibroma: Semantic Confusion. ( 28238823 )
2017
48
Peripheral osteoma, compound odontoma, focal cemento-osseous dysplasia, and cemento-ossifying fibroma in the same hemimandible: CBCT findings of an unusual case. ( 29484064 )
2017
49
Aggressive ossifying fibroma of right ethmoidal sinus: A case report. ( 29373206 )
2017
50
Conglomeration of Trabecular and Psammomatoid variants of juvenile ossifying fibroma - a rare case report. ( 28588818 )
2017

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
2
Show member pathways
13.42 JAG1 JAG2 MDM2 NOTCH1 NOTCH3 RASAL1
3
Show member pathways
12.64 GNAS JAG1 MDM2 NOTCH1 NOTCH3
4
Show member pathways
12.6 JAG1 JAG2 NOTCH1 NOTCH3
5
Show member pathways
12.48 JAG1 JAG2 NOTCH1 NOTCH3
6 12.45 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
7
Show member pathways
12.32 JAG1 JAG2 NOTCH1 NOTCH3
8
Show member pathways
12.3 JAG1 JAG2 NOTCH1 NOTCH3
9
Show member pathways
12.3 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
10 12.24 MDM2 NOTCH1 NOTCH3
11
Show member pathways
11.97 JAG1 JAG2 NOTCH1
12
Show member pathways
11.85 JAG1 JAG2 NOTCH1
13 11.74 MDM2 NOTCH1 NOTCH3
14 11.61 CDC73 JAG1 JAG2 NOTCH1 NOTCH3
15 11.56 JAG1 NOTCH1 NOTCH3
16 11.21 JAG1 JAG2 NOTCH1
17 10.78 JAG1 NOTCH1
18 10.75 JAG1 JAG2 NOTCH1
19 10.36 JAG1 JAG2 NOTCH1 NOTCH3

GO Terms for Ossifying Fibroma

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 GNAS JAG1 NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.93 JAG2 NOTCH1 NOTCH3 RASAL1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.92 CDC73 MDM2 NOTCH1 NOTCH3
3 regulation of cell proliferation GO:0042127 9.75 JAG1 JAG2 NOTCH1
4 positive regulation of osteoblast differentiation GO:0045669 9.63 GNAS JAG1
5 negative regulation of cell differentiation GO:0045596 9.63 JAG1 NOTCH1 NOTCH3
6 cell communication GO:0007154 9.62 JAG1 JAG2
7 protein destabilization GO:0031648 9.61 CDC73 MDM2
8 blood vessel remodeling GO:0001974 9.61 JAG1 MDM2
9 negative regulation of neuron differentiation GO:0045665 9.61 JAG1 NOTCH1 NOTCH3
10 neuron fate commitment GO:0048663 9.6 NOTCH1 NOTCH3
11 embryonic hindlimb morphogenesis GO:0035116 9.59 GNAS NOTCH1
12 neuronal stem cell population maintenance GO:0097150 9.58 JAG1 NOTCH1
13 aortic valve morphogenesis GO:0003180 9.57 JAG1 NOTCH1
14 positive regulation of transcription of Notch receptor target GO:0007221 9.56 NOTCH1 NOTCH3
15 endocardial cushion morphogenesis GO:0003203 9.55 MDM2 NOTCH1
16 negative regulation of stem cell differentiation GO:2000737 9.54 JAG1 NOTCH1
17 positive regulation of Notch signaling pathway GO:0045747 9.54 JAG1 JAG2 NOTCH1
18 pulmonary valve morphogenesis GO:0003184 9.52 JAG1 NOTCH1
19 atrioventricular valve morphogenesis GO:0003181 9.51 MDM2 NOTCH1
20 response to muramyl dipeptide GO:0032495 9.49 JAG1 NOTCH1
21 Notch signaling involved in heart development GO:0061314 9.48 JAG1 NOTCH1
22 regulation of developmental process GO:0050793 9.4 NOTCH1 NOTCH3
23 auditory receptor cell fate commitment GO:0009912 9.32 JAG2 NOTCH1
24 distal tubule development GO:0072017 9.26 JAG1 NOTCH1
25 Notch signaling pathway GO:0007219 9.26 JAG1 JAG2 NOTCH1 NOTCH3
26 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.16 JAG1 NOTCH1
27 cardiac septum morphogenesis GO:0060411 8.8 JAG1 MDM2 NOTCH1

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 JAG1 JAG2 NOTCH1 NOTCH3
2 Notch binding GO:0005112 8.8 JAG1 JAG2 NOTCH1

Sources for Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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