MCID: OSS001
MIFTS: 42

Ossifying Fibroma

Categories: Bone diseases, Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

MalaCards integrated aliases for Ossifying Fibroma:

Name: Ossifying Fibroma 12 15 17 70
Peripheral Ossifying Fibroma 12 70
Fibroma, Ossifying 44
Fibroma Ossifying 54
Fibro-Osteoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:180
MeSH 44 D018214
NCIt 50 C8422
SNOMED-CT 67 189896007
UMLS 70 C0206640 C1290783

Summaries for Ossifying Fibroma

Disease Ontology : 12 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary : Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and fibroma. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. Affiliated tissues include mouth, bone and bone marrow, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 juvenile ossifying fibroma 33.0 RASAL1 MDM2
2 fibroma 31.8 USP6 SERPINA3 NF1 CDC73
3 fibrous dysplasia 31.6 GNAS FGFR1 CDC73
4 parathyroid adenoma 30.3 PTH GNAS CDC73
5 encephalocraniocutaneous lipomatosis 30.2 KRAS FGFR1
6 osteitis fibrosa 29.8 PTH GNAS CDC73
7 dedifferentiated liposarcoma 29.8 SERPINA3 NF1 MDM2
8 multiple endocrine neoplasia 29.8 PTH NF1 GNAS CDC73
9 adenoma 29.8 PTH KRAS GNAS CDC73
10 giant cell reparative granuloma 29.6 USP6 SERPINA3 PTH NF1
11 multiple endocrine neoplasia, type i 29.6 PTH NF1 GNAS CDC73
12 hyperparathyroidism 2 with jaw tumors 11.5
13 osteofibrous dysplasia 11.4
14 gigantiform cementoma, familial 11.4
15 exophthalmos 10.7
16 aneurysmal bone cysts 10.6
17 overgrowth syndrome 10.6
18 osteogenic sarcoma 10.5
19 gingival overgrowth 10.5
20 pyogenic granuloma 10.5
21 hyperparathyroidism 10.5
22 osteoblastoma 10.4
23 epulis 10.4
24 neurofibromatosis 10.4
25 meningioma, familial 10.4
26 intracranial meningioma 10.4
27 secretory meningioma 10.4
28 lymphoplasmacyte-rich meningioma 10.4
29 monostotic fibrous dysplasia 10.4
30 rare tumor 10.3
31 nodular regenerative hyperplasia 10.3 NOTCH1 JAG1
32 atypical coarctation of aorta 10.3 NF1 JAG1
33 osteomyelitis 10.3
34 root resorption 10.3
35 odontoma 10.3
36 breast juvenile papillomatosis 10.3 NF1 GNAS
37 pulmonic stenosis 10.3 NF1 JAG1
38 adult liposarcoma 10.3 NOTCH1 MDM2
39 periosteal osteogenic sarcoma 10.3 MDM2 GNAS
40 cdc73-related disorders 10.3
41 wilms tumor predisposition 10.3 NF1 CDC73
42 spinal cord oligodendroglioma 10.2 NF1 FGFR1
43 juxtacortical osteosarcoma 10.2 MDM2 GNAS
44 peripheral osteosarcoma 10.2 MDM2 GNAS
45 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.2 NOTCH1 FGFR1
46 appendiceal neoplasm 10.2 KRAS GNAS
47 appendix adenocarcinoma 10.2 KRAS GNAS
48 chondrosarcoma 10.2
49 osteoid osteoma 10.2
50 yemenite deaf-blind hypopigmentation syndrome 10.2

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.38 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
2 behavior/neurological MP:0005386 10.36 CDC73 FGFR1 GNAS JAG1 KRAS MDM2
3 cardiovascular system MP:0005385 10.35 CDC73 FGFR1 GNAS JAG1 KRAS MDM2
4 homeostasis/metabolism MP:0005376 10.35 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
5 craniofacial MP:0005382 10.34 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
6 endocrine/exocrine gland MP:0005379 10.32 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
7 cellular MP:0005384 10.3 CDC73 FGFR1 GNAS JAG1 KRAS MDM2
8 hematopoietic system MP:0005397 10.29 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
9 integument MP:0010771 10.29 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
10 immune system MP:0005387 10.26 CDC73 FGFR1 GNAS JAG2 KRAS MDM2
11 digestive/alimentary MP:0005381 10.24 CDC73 FGFR1 JAG1 JAG2 KRAS MDM2
12 embryo MP:0005380 10.24 CDC73 FGFR1 JAG1 JAG2 KRAS MDM2
13 mortality/aging MP:0010768 10.23 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
14 hearing/vestibular/ear MP:0005377 10.16 FGFR1 GNAS JAG1 JAG2 KRAS NF1
15 muscle MP:0005369 10.09 CDC73 FGFR1 GNAS JAG1 KRAS MDM2
16 liver/biliary system MP:0005370 10.08 CDC73 GNAS JAG1 KRAS MDM2 NF1
17 nervous system MP:0003631 10.07 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS
18 limbs/digits/tail MP:0005371 10.04 FGFR1 GNAS JAG2 KRAS MDM2 NF1
19 neoplasm MP:0002006 9.95 CDC73 GNAS KRAS MDM2 NF1 NOTCH1
20 normal MP:0002873 9.86 FGFR1 GNAS JAG1 KRAS MDM2 NF1
21 renal/urinary system MP:0005367 9.85 CDC73 FGFR1 GNAS JAG1 KRAS MDM2
22 no phenotypic analysis MP:0003012 9.8 FGFR1 GNAS JAG1 JAG2 KRAS MDM2
23 respiratory system MP:0005388 9.56 CDC73 GNAS JAG2 KRAS NF1 NOTCH1
24 skeleton MP:0005390 9.4 CDC73 FGFR1 GNAS JAG1 JAG2 KRAS

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

The Foundational Model of Anatomy Ontology organs/tissues related to Ossifying Fibroma:

19
Mouth

MalaCards organs/tissues related to Ossifying Fibroma:

40
Bone, Bone Marrow, Eye, Smooth Muscle, Colon, Thyroid, T Cells

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 1317)
# Title Authors PMID Year
1
HRPT2 gene alterations in ossifying fibroma of the jaws. 61 54
16458039 2006
2
Review of Pediatric Head and Neck Neoplasms that Raise the Possibility of a Cancer Predisposition Syndrome. 61
33723760 2021
3
Juvenile Psammomatoid Cemeto-ossifying Fibroma of Mandible: a Diagnostic dilemma. 61
33741572 2021
4
Entirely endoscopic resection of a complicated juvenile psammomatoid ossifying fibroma of the paranasal sinusitis: Case report and review of the literature. 61
33743250 2021
5
Gingival Fibroma: An Emerging Distinct Gingival Lesion with Well-Defined Histopathology. 61
33686583 2021
6
A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws. 61
32730731 2021
7
Fibro-Osseous Lesions Of The Craniofacial Complex In Horses: 30 Cases (2001-2019). 61
33399249 2021
8
Cemento-ossifying fibroma and juvenile ossifying fibroma: Clarity in terminology. 61
33129707 2021
9
Endonasal Endoscopic Approach for a Psammomatous Juvenile Active Ossifying Fibroma: 2-Dimensional Operative Video. 61
33588435 2021
10
Ossifying Fibroma in the Nasal Cavity of a 2-Year-Old Horse. 61
33513907 2021
11
Endoscopic Resection of a Massive Ossifying Fibroma in the Sinonasal Cavity. 61
33534305 2021
12
Rare case of juvenile ossifying fibroma of the lumbar spine causing vertebra plana. 61
33462042 2021
13
Spheno-orbital juvenile psammomatoid ossifying fibroma: a case report and literature review. 61
33404728 2021
14
Surgical resection of a giant peripheral ossifying fibroma in mouth floor managed with fiberscopic intubation. 61
33489156 2021
15
Fibro-osseous Lesions of Paranasal Sinus and Craniofacial Region: A Retrospective Study of 282 Cases. 61
32057109 2021
16
The Clinical and Radiological Outcome of Stages 1 and 2 Enneking Benign Bone Lesions with Pathological Fracture. 61
33541686 2021
17
Osseous mass in a maxillary sinus of an adult male from the 16th-17th-century Spain: Differential diagnosis. 61
32937254 2020
18
Possible Novel Treatment Modality for Non Ossifying Fibroma Neck of Femur. 61
33402782 2020
19
Central ossifying fibroma of mandible. 61
33372024 2020
20
Ossifying fibroma of the jaw bones in hyperparathyroidism-jaw tumor syndrome: Analysis of 24 cases retrieved from literatures. 61
33505612 2020
21
[Tumors affecting the temporomandibular joint - a literature review]. 61
33059872 2020
22
Primary Bone Tumors in North of Jordan. 61
33605114 2020
23
SATB2 is not a reliable diagnostic marker for distinguishing between oral osteosarcoma and fibro-osseous lesions of the jaws. 61
33309262 2020
24
Chondroblastic osteosarcoma-A case report and review of literature. 61
33235735 2020
25
[Clinical application and accuracy analysis of occlusion-guided functional mandibular reconstruction]. 61
33191699 2020
26
Histochemical characterization of bone and cementum using modified gallego's iron fuschin stain and van gieson stain and its application in fibro-osseous lesions. 61
33753659 2020
27
Long-term Clinical Course of Benign Fibro-osseous Lesions in the Paranasal Sinuses. 61
33152810 2020
28
Immediate Reconstruction of Segmental Mandibular Defects With Nonvascular Bone Grafts: A 30-Year Perspective. 61
33131550 2020
29
Genetic testing for hereditary hyperparathyroidism and familial hypocalciuric hypercalcaemia in a large UK cohort. 61
32430905 2020
30
Displaced distal femur metaphyseal fractures: clinical and radiographic outcome in children aged 6-16 years treated by elastic stable intramedullary nailing. 61
33038148 2020
31
Unusual exophytic gingival lesion in a newborn treated with diode laser. 61
32107185 2020
32
Jaffe-Lichtenstein Syndrome Associated with a Simple Bone Cyst: Unprecedented Rare Case Report. 61
33146341 2020
33
[Tumor-like bony lesions of the skeleton]. 61
32840666 2020
34
Juvenile psammomatoid ossifying fibroma of the calcaneus. 61
32816930 2020
35
Comparison of characteristic features and local recurrence in syndromic versus non-syndromic multifocal non-ossifying fibroma. 61
32819790 2020
36
68Ga DOTA-TOC Uptake in Non-ossifying Fibroma: a Case Report. 61
32831966 2020
37
Ossifying Fibroma of the Cervical Spine: First Case Report and Literature Review. 61
32437986 2020
38
[Tumor-like bony lesions of the skeleton]. 61
32556370 2020
39
Intracranial bony ball - An ossified variant of meningioma. 61
32769336 2020
40
Diode laser-assisted management of intraoral soft tissue overgrowth: a case series. 61
32597774 2020
41
Endoscopic Optic Nerve Decompression for Optic Neuropathy in Sinonasal Fibro-Osseous Tumors. 61
32105872 2020
42
Delayed Infection of Porous Polyethylene Implants After Oncologic Maxillectomy and Reconstruction: 2 Case Reports and Review of Literature. 61
32538671 2020
43
Ossifying fibroma in the maxilla and orbital floor: report of an uncommon case. 61
32606282 2020
44
Juvenile psammomatoid ossifying fibroma of the maxilla. 61
32630994 2020
45
Ossifying fibroma arising from the zygomatic arch: A case report. 61
31476540 2020
46
Jaffe-Campanacci syndrome or neurofibromatosis type 1: a case report of phenotypic overlap with detection of NF1 gene mutation in non-ossifying fibroma. 61
32393377 2020
47
Intraoral Approach for Surgical Treatment of Psammomatoid Juvenile Ossifying Fibroma. 61
31934971 2020
48
Spectrum of histological features of Denosumab treated Giant Cell Tumor of Bone; potential pitfalls and diagnostic challenges for pathologists. 61
32088577 2020
49
[Clinical characteristics and surgical treatment analysis of paranasal ossifying fibroma]. 61
32842232 2020
50
A Non-ossifying Fibroma and a Stress Fracture of the Femur Mimicking Bone Malignancy in a Child. 61
32411553 2020

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 RASAL1 PTH NOTCH3 NOTCH1 NF1 MDM2
2
Show member pathways
13.52 RASAL1 NOTCH3 NOTCH1 NF1 MDM2 KRAS
3
Show member pathways
12.64 NOTCH3 NOTCH1 MDM2 KRAS JAG1 GNAS
4
Show member pathways
12.57 RASAL1 NF1 KRAS GNAS FGFR1
5
Show member pathways
12.51 NOTCH3 NOTCH1 KRAS JAG2 JAG1 FGFR1
6
Show member pathways
12.42 NOTCH3 NOTCH1 JAG2 JAG1
7
Show member pathways
12.38 NOTCH3 NOTCH1 JAG2 JAG1
8 12.33 NOTCH3 NOTCH1 MDM2 KRAS
9 12.28 NOTCH3 NOTCH1 MDM2 KRAS JAG2 JAG1
10 11.98 NOTCH3 NOTCH1 JAG2 JAG1 CDC73
11
Show member pathways
11.95 NOTCH1 JAG2 JAG1
12 11.92 NOTCH3 KRAS JAG1
13
Show member pathways
11.91 RASAL1 NF1 KRAS
14
Show member pathways
11.89 RASAL1 NF1 KRAS
15
Show member pathways
11.88 NOTCH3 NOTCH1 NF1 MDM2 KRAS JAG2
16 11.86 NOTCH3 NOTCH1 MDM2 KRAS
17 11.8 NF1 MDM2 KRAS
18 11.76 PTH GNAS FGFR1
19 11.73 NOTCH3 NOTCH1 FGFR1
20 11.68 NOTCH3 NOTCH1 JAG1 FGFR1
21 11.35 NOTCH1 JAG2 JAG1
22 10.89 NOTCH3 NOTCH1 JAG2 JAG1
23 10.84 NOTCH1 JAG2 JAG1
24 10.82 NOTCH1 JAG1

GO Terms for Ossifying Fibroma

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.84 RASAL1 NF1 KRAS FGFR1
2 liver development GO:0001889 9.72 NOTCH1 NF1 KRAS
3 negative regulation of cell differentiation GO:0045596 9.7 NOTCH1 KRAS JAG1
4 positive regulation of Notch signaling pathway GO:0045747 9.69 NOTCH1 JAG2 JAG1
5 cell communication GO:0007154 9.65 NF1 JAG2 JAG1
6 neuronal stem cell population maintenance GO:0097150 9.62 NOTCH1 JAG1
7 positive regulation of transcription of Notch receptor target GO:0007221 9.61 NOTCH3 NOTCH1
8 endocardial cushion morphogenesis GO:0003203 9.61 NOTCH1 MDM2
9 negative regulation of stem cell differentiation GO:2000737 9.6 NOTCH1 JAG1
10 pulmonary valve morphogenesis GO:0003184 9.59 NOTCH1 JAG1
11 atrioventricular valve morphogenesis GO:0003181 9.58 NOTCH1 MDM2
12 response to muramyl dipeptide GO:0032495 9.58 NOTCH1 JAG1
13 Notch signaling involved in heart development GO:0061314 9.57 NOTCH1 JAG1
14 negative regulation of oligodendrocyte differentiation GO:0048715 9.56 NOTCH1 NF1
15 response to parathyroid hormone GO:0071107 9.49 PTH GNAS
16 regulation of developmental process GO:0050793 9.46 NOTCH3 NOTCH1
17 Notch signaling pathway GO:0007219 9.46 NOTCH3 NOTCH1 JAG2 JAG1
18 distal tubule development GO:0072017 9.43 NOTCH1 JAG1
19 homeostasis of number of cells within a tissue GO:0048873 9.43 PTH NOTCH1 KRAS
20 auditory receptor cell fate commitment GO:0009912 9.4 NOTCH1 JAG2
21 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.37 NOTCH1 JAG1
22 forebrain astrocyte development GO:0021897 9.32 NF1 KRAS
23 cardiac septum morphogenesis GO:0060411 9.13 NOTCH1 MDM2 JAG1
24 skeletal system development GO:0001501 9.02 TRPS1 PTH JAG2 GNAS FGFR1

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 8.8 NOTCH1 JAG2 JAG1

Sources for Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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