MCID: OSS001
MIFTS: 37

Ossifying Fibroma

Categories: Bone diseases, Cancer diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Ossifying Fibroma

MalaCards integrated aliases for Ossifying Fibroma:

Name: Ossifying Fibroma 11 14 16 71
Peripheral Ossifying Fibroma 11 71 75
Fibroma, Ossifying 43
Fibroma Ossifying 53
Fibro-Osteoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:180
MeSH 43 D018214
NCIt 49 C8422
SNOMED-CT 68 189896007
UMLS 71 C0206640 C1290783

Summaries for Ossifying Fibroma

Disease Ontology: 11 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to hyperparathyroidism 2 with jaw tumors and fibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signal Transduction and FGF23 signaling in hypophosphatemic rickets and related disorders. Affiliated tissues include mouth, bone and bone marrow, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 A peripheral ossifying fibroma, also known as ossifying fibrous epulis, is “a gingival nodule which is... more...

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 hyperparathyroidism 2 with jaw tumors 32.8 MEN1 CDC73
2 fibrous dysplasia 31.7 GNAS FGF23 CDC73
3 fibroma 31.1 USP6 SERPINA3 SATB2 NF1 GNAS CDC73
4 hyperparathyroidism 30.8 PTH MEN1 FGF23 CDC73
5 parathyroid adenoma 30.6 PTH MEN1 GNAS CDC73
6 epulis 30.3 SH3BP2 SERPINA3 CDC73 CD34
7 primary hyperparathyroidism 30.3 PTH MEN1 FGF23 CDC73
8 adenoma 30.3 PTH MEN1 GNAS CDC73
9 neurofibromatosis, type i 30.3 NF1 MEN1 CD34
10 osteomalacia 30.2 PTH MEPE FGF23
11 telangiectatic osteogenic sarcoma 30.2 USP6 H3-3B H3-3A
12 giant cell reparative granuloma 30.2 USP6 SH3BP2 SERPINA3 PTH NF1 H3-3A
13 osteoblastoma 30.2 USP6 SATB2 PTH MEPE FGF23
14 secondary hyperparathyroidism 30.1 PTH MEN1 FGF23
15 meningioma, familial 30.1 SERPINA3 NF1 MEN1 CD34
16 multiple endocrine neoplasia 30.1 PTH NF1 MEN1 GNAS CDC73
17 osteitis fibrosa 30.0 PTH GNAS FGF23 CDC73
18 rickets 30.0 PTH MEPE FGF23
19 mesenchymal cell neoplasm 29.9 SERPINA3 NF1 FGF23 CD34
20 multiple endocrine neoplasia, type i 29.8 PTH NF1 MEN1 GNAS CDC73
21 hypophosphatemia 29.8 PTH MEPE GNAS FGF23
22 mccune-albright syndrome 29.8 PTH NF1 MEPE MEN1 GNAS FGF23
23 well-differentiated liposarcoma 29.8 SERPINA3 NF1 CD34
24 spindle cell sarcoma 29.8 SERPINA3 NF1 CD34
25 dedifferentiated liposarcoma 29.8 SERPINA3 NF1 CD34
26 osteochondrodysplasia 29.2 PTH NF1 MEPE GNAS FGF23 ANO5
27 bone giant cell tumor 29.1 USP6 SH3BP2 SERPINA3 SATB2 PTH H3-3B
28 osteofibrous dysplasia 11.7
29 juvenile ossifying fibroma 11.7
30 gigantiform cementoma, familial 11.4
31 bone cancer 10.7
32 aneurysmal bone cysts 10.7
33 osteogenic sarcoma 10.6
34 pyogenic granuloma 10.6
35 overgrowth syndrome 10.6
36 gingival overgrowth 10.6
37 hemifacial hyperplasia 10.5
38 cerebrooculofacioskeletal syndrome 1 10.4
39 neurofibromatosis 10.4
40 monostotic fibrous dysplasia 10.4
41 neurofibromatosis-noonan syndrome 10.4
42 rare tumor 10.4
43 florid cemento-osseous dysplasia 10.4
44 malignant fibrous histiocytoma of bone 10.4 SERPINA3 CDC73
45 water-clear cell adenoma 10.3 PTH CDC73
46 thyroid gland hurthle cell carcinoma 10.3 SERPINA3 CDC73
47 fanconi anemia, complementation group e 10.3
48 osteomyelitis 10.3
49 root resorption 10.3
50 odontoma 10.3

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.29 ANO5 CD34 CDC73 FGF23 GNAS H3-3A
2 growth/size/body region MP:0005378 10.23 ANO5 CDC73 FGF23 GNAS H3-3A H3-3B
3 cellular MP:0005384 10.11 ANO5 CD34 CDC73 GNAS H3-3A H3-3B
4 immune system MP:0005387 10.1 ANO5 CD34 CDC73 FGF23 GNAS MEN1
5 limbs/digits/tail MP:0005371 10.04 ANO5 FGF23 GNAS NF1 PTH SATB2
6 craniofacial MP:0005382 10.01 ANO5 CDC73 GNAS MEN1 NF1 PTH
7 neoplasm MP:0002006 9.99 CD34 CDC73 GNAS MEN1 MIR31 NF1
8 digestive/alimentary MP:0005381 9.98 CDC73 FGF23 GNAS MEN1 NF1 SATB2
9 reproductive system MP:0005389 9.81 ANO5 CDC73 FGF23 H3-3A H3-3B MEN1
10 respiratory system MP:0005388 9.8 CDC73 FGF23 GNAS MEN1 NF1 SATB2
11 skeleton MP:0005390 9.65 ANO5 CDC73 FGF23 GNAS MEN1 MEPE
12 integument MP:0010771 9.23 CD34 CDC73 FGF23 GNAS MIR31 NF1

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials, NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

Organs/tissues related to Ossifying Fibroma:

FMA: Mouth
MalaCards : Bone, Bone Marrow, Smooth Muscle, T Cells, Colon, Thyroid, Eye

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 1450)
# Title Authors PMID Year
1
HRPT2 gene alterations in ossifying fibroma of the jaws. 53 62
16458039 2006
2
Transformation of Cemento-Ossifying Fibroma into Osteosarcoma after Radiotherapy and Nine Endoscopic Surgeries. 62
35575211 2023
3
Juvenile psammomatoid ossifying fibroma in paranasal sinuses: A case report and literature review. 62
36324855 2023
4
Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma: Close Relatives or Family? 62
35524033 2022
5
MDM2 Gene Amplification and Expression of MDM2 and CDK4 are Rare in Ossifying Fibroma of Craniofacial Bones. 62
35546651 2022
6
Management of juvenile trabecular ossifying fibroma of bone of the maxilla in a child: A case report at a tertiary hospital in Northern Tanzania. 62
36257140 2022
7
A novel technique to repair orbital roof defects: irradiated homologous cadaveric rib (Tutoplast ®) graft in a recurrent frontal sinus ossifying fibroma. 62
36425586 2022
8
Juvenile psammomatoid ossifying fibroma of the maxilla and mandible: A systematic review of published case reports. 62
36325758 2022
9
Endoscopic Transnasal Management of Giant Paediatric Sinonasal Ossifying Fibroma. 62
36452801 2022
10
Three Cases of Mandibular Ossifying Fibroma in Cattle. 62
36116887 2022
11
Peripheral Ossifying Fibroma Veiling a Nasopalatine Duct Cyst: An Unusual Concurrence. 62
36452642 2022
12
Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours. 62
35612673 2022
13
Role of MDM2, CDK4, BCL2, Parafibromin and Galectin 1 in Differentiating Osteosarcoma from its Benign Fibro-osseous Lesions. 62
35220546 2022
14
Aneurysmal bone cyst on top of fibro-osseous lesion of the ethmoid sinus with orbital and intracranial extension in a child. 62
36101731 2022
15
A two-generation hyperparathyroidism-jaw tumor (HPT-JT) syndrome family: clinical presentations, pathological characteristics and genetic analysis: a case report. 62
36153594 2022
16
Fibrous dysplasia in cardio-facio-cutaneous syndrome: A case report and review of literature. 62
35801299 2022
17
Peripheral ossifying fibroma: A 20-year retrospective study with focus on clinical and morphological features. 62
35717619 2022
18
Mandibular Osteoma in a Haflinger Mare: Clinical and Pathological Features. 62
35716838 2022
19
Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor. 62
36127985 2022
20
Juvenile aggressive ossifying fibroma. 62
36393953 2022
21
Aneurysmal Bone Cyst Plus Lesions: A Case Report and a Literature Review. 62
36120211 2022
22
Juvenile psammomatoid ossifying fibroma with aneurysmal bone cyst in the mandible: A report of a rare case. 62
36393963 2022
23
An interdisciplinary approach for the management and rehabilitation of a fibro-osseous neoplasm using platelet-rich gel and an implant-supported hybrid prosthesis. 62
36393939 2022
24
Delayed Eruption of Tooth Due to Peripheral Giant-Cell Granuloma: An Unusual Presentation and Treatment in 15-Year-Old Child Patient. 62
36110691 2022
25
Pathological Fractures in Benign Bone Lesions - Diagnosis and Therapy. 62
35882354 2022
26
Direct evidence supporting a periodontal ligament origin for central cemento-ossifying fibroma. 62
35610173 2022
27
Endoscopic Endonasal Trans-Agger Nasi Approach for Resection of Ossifying Fibroma Involving the Anterior Skull Base: Surgical Anatomy and Technical Note. 62
35861707 2022
28
Fibro-Osseous Lesion of the Nose and Paranasal Sinus: A Retrospective Study With Literature Review. 62
36035031 2022
29
Focal Cemento Osseous Dysplasia: A Case Report. 62
35783499 2022
30
Aggressive juvenile ossifying fibroma of the ethmoid sinus with orbital and intracranial extension: A case report. 62
35738137 2022
31
Juvenile Psammomatoid Ossifying Fibroma of the Orbital Roof: A Rare Presentation. 62
35657673 2022
32
SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma. 62
34224081 2022
33
Recurrent Gingival Lesions in a Pediatric Patient. 62
35720203 2022
34
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis. 62
34401975 2022
35
[A large maxillary fibroepithelial polyp: a lump in the throat]. 62
35670462 2022
36
Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review. 62
34716904 2022
37
The importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws: Study of 276 cases. 62
33878496 2022
38
Odontogenic tumors: A Retrospective Study in Egyptian population using WHO 2017 classification. 62
35420069 2022
39
Pediatric Aggressive Benign Mandibular Tumors: Clinical Features and Management. 62
34387270 2022
40
Unicortical Bone Necrosis of the Fibula Free Flap Associated to the Fixation with a Nonlocking 2.0-mm Reconstruction Plate and Screws. 62
35832144 2022
41
[Giant cell-containing tumors of bone and differential diagnoses]. 62
35467097 2022
42
Benign bony tumors of the paranasal sinuses, orbit, and skull base. 62
35246319 2022
43
Combined lesion of central giant cell granuloma and ossifying fibroma: A case report of a rare event in oral cavity. 62
35439729 2022
44
Ossifying Fibroma of the Orbit Presenting with Recurrent Globe Subluxation. 62
35142746 2022
45
Immunohistochemical evaluation of IL-1β, IL-6, TNF-α and IL-17 cytokine expression in peripheral giant cell granuloma and peripheral ossifying fibroma of the jaws. 62
35231725 2022
46
Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento-ossifying fibroma pathogenesis. 62
35103997 2022
47
[Giant-cell tumor of bone in 2022]. 62
35523609 2022
48
Non-ossifying fibromas and fibrous cortical defects around the knee - an epidemiologic survey in a Japanese pediatric population. 62
35459158 2022
49
Ossifying Fibromas of the Head and Neck Region: A Clinicopathological Study of 45 Cases. 62
34184157 2022
50
"Endotracheal Tube" as a Temporary Method of Mandibular Reconstruction in Infant with Juvenile Ossifying Fibroma. 62
35400926 2022

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.69 RASAL1 PTH NF1 MEN1 H3-3B H3-3A
3 10.1 SATB2 NF1

GO Terms for Ossifying Fibroma

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome, telomeric region GO:0000781 9.23 MEN1 H3-3B H3-3A CDC73

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to parathyroid hormone GO:0071107 8.8 PTH GNAS

Sources for Ossifying Fibroma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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