Ossifying Fibromyxoid Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OSS002 MIFTS: 28	Ossifying Fibromyxoid Tumor Categories: Cancer diseases
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Aliases & Classifications for Ossifying Fibromyxoid Tumor

MalaCards integrated aliases for Ossifying Fibromyxoid Tumor:

Name: Ossifying Fibromyxoid Tumor ¹² ¹⁵ ¹⁷ ⁷⁰

Ossifying Fibromyxoid Tumour ¹²

Ossifying Fibromyxoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2685

NCIt ⁵⁰ C6582

SNOMED-CT ⁶⁷ 404076001

EFO ¹⁷ EFO_1000408

UMLS ⁷⁰ C1266128

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Summaries for Ossifying Fibromyxoid Tumor

MalaCards based summary : Ossifying Fibromyxoid Tumor, also known as ossifying fibromyxoid tumour, is related to rare tumor and epidermoid cysts. An important gene associated with Ossifying Fibromyxoid Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. Affiliated tissues include kidney, thyroid and brain.

Wikipedia : ⁷³ An ossifying fibromyxoid tumor is a type of myxoma. It presents in the extremities more frequently than... more...

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Related Diseases for Ossifying Fibromyxoid Tumor

Diseases related to Ossifying Fibromyxoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)

#	Related Disease	Score	Top Affiliating Genes
1	rare tumor	31.3	DES ACTC1
2	epidermoid cysts	30.5	S100B S100A1
3	secretory meningioma	30.5	VIM MUC1
4	pseudosarcomatous fibromatosis	30.5	VIM DES ACTC1
5	chondroma	30.4	S100A1 ACTC1
6	neuroma	30.4	S100B MUC1 ENO2
7	sarcoma	30.2	VIM S100B MUC1 ACTC1
8	fibroma	30.2	VIM S100A1 DES ACTC1
9	smooth muscle tumor	30.2	VIM S100A1 DES ACTC1
10	neurofibroma	30.2	VIM S100B S100A1 MUC1 ACTC1
11	meningioma, familial	30.1	VIM S100B S100A1 MUC1
12	malignant peripheral nerve sheath tumor	30.0	VIM S100B S100A1 MUC1 ACTC1
13	pleomorphic adenoma	29.8	VIM S100B S100A1 MUC1 DES ACTC1
14	neurilemmoma	29.5	VIM S100B S100A1 MUC1 ENO2 DES
15	spindle cell sarcoma	28.9	VIM S100B MUC1 MAML3 DES CCNB3
16	rare soft tissue tumor	10.5
17	fibroblastic rheumatism	10.4	DES ACTC1
18	ovarian fibrothecoma	10.4	DES ACTC1
19	adult cystic nephroma	10.4	DES ACTC1
20	myopericytoma	10.4	S100B ACTC1
21	pulmonary vein stenosis	10.3	DES ACTC1
22	malignant giant cell tumor	10.3	S100B ACTC1
23	lymphangiectasis	10.3	VIM ACTC1
24	botryoid rhabdomyosarcoma	10.3	DES ACTC1
25	osteogenic sarcoma	10.3
26	sclerosing perineurioma	10.3	S100B MUC1
27	localized hypertrophic neuropathy	10.3	S100B MUC1
28	intravascular papillary endothelial hyperplasia	10.3	VIM ACTC1
29	reticular perineurioma	10.3	S100B MUC1
30	malignant triton tumor	10.3	S100B DES
31	glomangiomyoma	10.3	VIM ACTC1
32	infantile digital fibromatosis	10.3	VIM DES
33	pilomatrix carcinoma	10.3	MUC1 ENO2
34	aggressive digital papillary adenocarcinoma	10.3	S100B MUC1
35	head injury	10.3	S100B ENO2
36	lymphangiomatosis	10.3	VIM DES
37	hydromyelia	10.3	VIM S100B
38	myofibroma	10.3	S100A1 DES
39	cerebral primitive neuroectodermal tumor	10.3	S100B MUC1
40	pineocytoma	10.3	S100B ENO2
41	primary hepatic neuroendocrine carcinoma	10.3	VIM S100B
42	malignant giant cell tumor of soft parts	10.3	S100B ACTC1
43	sinonasal undifferentiated carcinoma	10.3	MUC1 ENO2
44	non-langerhans-cell histiocytosis	10.3	DES ACTC1
45	bile duct mucinous adenocarcinoma	10.3	MUC1 ENO2
46	non-functioning pituitary adenoma	10.3	S100B MUC1
47	middle ear adenoma	10.3	MUC1 ENO2
48	akinetic mutism	10.3	S100B ENO2
49	epithelioid trophoblastic tumor	10.3	MUC1 ACTC1
50	post-cardiac arrest syndrome	10.3	S100B ENO2

Graphical network of the top 20 diseases related to Ossifying Fibromyxoid Tumor:

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Symptoms & Phenotypes for Ossifying Fibromyxoid Tumor

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Drugs & Therapeutics for Ossifying Fibromyxoid Tumor

Search Clinical Trials , NIH Clinical Center for Ossifying Fibromyxoid Tumor

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Genetic Tests for Ossifying Fibromyxoid Tumor

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Anatomical Context for Ossifying Fibromyxoid Tumor

MalaCards organs/tissues related to Ossifying Fibromyxoid Tumor:

⁴⁰

Kidney, Thyroid, Brain, Tongue, Spinal Cord, Breast, Skin

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Publications for Ossifying Fibromyxoid Tumor

Articles related to Ossifying Fibromyxoid Tumor:

(show top 50) (show all 129)

#	Title	Authors	PMID	Year
1	Differential diagnosis of T2 hypointense masses in musculoskeletal MRI. ⁶¹	Finkelstein D...Subhawong TK	33651128	2021
2	Reduced S100 Protein Expression in Malignant Ossifying Fibromyxoid Tumors: A Case Report. ⁶¹	Foster-Davies H...Brotto M	33786264	2021
3	Ossifying fibromyxoid tumor in the lower extremity mimicking a sebaceous cyst. Case report and literature review. ⁶¹	Mohamed S...Abusabeib A	33450587	2021
4	Pan-Trk immunoexpression in a superficial malignant ossifying fibromyxoid tumor with ZC3H7B-BCOR fusion: A potential obfuscating factor in the era of targeted therapy. ⁶¹	Linos K...Bridge JA	33169434	2021
5	Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations. ⁶¹	Ando M...Yamasoba T	31879078	2020
6	Superficial malignant ossifying fibromyxoid tumors harboring the rare and recently described ZC3H7B-BCOR and PHF1-TFE3 fusions. ⁶¹	Linos K...Bridge JA	32352579	2020
7	Synchronous Occurrence of Colloid Cyst With Intracranial Ossifying Fibromyxoid Tumor Masquerading as Meningioma. ⁶¹	Dhawan S...Singh A	33014664	2020
8	PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells. ⁶¹	Hofvander J...Mertens F	31932680	2020
9	Ossifying fibromyxoid tumor: Fine-needle aspiration cytology findings of a rare soft tissue neoplasm. ⁶¹	Kumari N...Singh A	31925994	2020
10	Supraclavicular malignant ossifying fibromyxoid tumor. ⁶¹	Jimenez Gomez M...Hernandez Hernandez JR	31155141	2020
11	[Ossifying fibromyxoid tumor: clinicolpathological futures of 3 cases]. ⁶¹	Liu D...Hu HM	32074732	2020
12	What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. ⁶¹	Kao YC...Huang HY	31701222	2020
13	Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis. ⁶¹	Carter CS...Patel RM	31765250	2019
14	Novel recurrent PHF1-TFE3 fusions in ossifying fibromyxoid tumors. ⁶¹	Suurmeijer AJH...Antonescu CR	30920708	2019
15	Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma. ⁶¹	Panagopoulos I...Heim S	31467228	2019
16	Ossifying fibromyxoid tumor: a rare case. ⁶¹	Umer M...Hilal K	31466971	2019
17	Fine-needle aspiration features of ossifying fibromyxoid tumor in the breast: A case report and literature review. ⁶¹	Gajdzis P...Klijanienko J	30912617	2019
18	Oncogenic Osteomalacia with Elevated Fibroblast Growth Factor 23: A Rare Case of Paranasal Sinus Tumor Onset. ⁶¹	Rigante M...Paludetti G	31423395	2019
19	Subcutaneous ossifying fibromyxoid tumor of the scalp: a potential importance of CT, MRI, and PET/CT on the diagnosis. ⁶¹	Namiki T...Yokozeki H	30883693	2019
20	Ossifying Fibromyxoid Tumor with Spinal Cord Compression and Epiduritis. ⁶¹	De Wandeler T...Jissendi Tchofo P	30854506	2019
21	INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ⁶¹	Yoshida A...Hiraoka N	29327709	2018
22	Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review. ⁶¹	Velasco IA...Wang D	29587781	2018
23	A rare case report of a typical variant ossifying fibromyxoid tumor (OFMT), located in the retroauricular perimastoid region. ⁶¹	Varakliotis T...Casorati F	29462752	2018
24	Soft Tissue Tumors of Uncertain Histogenesis: A Review for Dermatopathologists. ⁶¹	Buehler D...Weisman P	28802505	2017
25	Ossifying Fibromyxoid Tumor of the Retromolar Trigone: A Case Report and Systematic Review of the Literature. ⁶¹	Titsinides S...Sklavounou A	28436288	2017
26	Ossifying fibromyxoid tumor: a study of 6 cases of atypical and malignant variants. ⁶¹	Dantey K...Rao UNM	27816723	2017
27	A rare soft tissue tumor located in the trunk: Ossifying fibromyxoid tumor. ⁶¹	Dere Y...Dere O	29260139	2017
28	Expanding the molecular signature of ossifying fibromyxoid tumors with two novel gene fusions: CREBBP-BCORL1 and KDM2A-WWTR1. ⁶¹	Kao YC...Antonescu CR	27537276	2017
29	Ossifying fibromyxoid tumor of the trunk mimicking hydatid cyst: A case report. ⁶¹	Abdessayed N...Mokni M	28822312	2017
30	Response to isolated limb perfusion and chemotherapy with epirubicin plus ifosfamide in a metastatic malignant ossifying fibromyxoid tumor. ⁶¹	Provenzano S...Casali PG	29299229	2017
31	Atypical ossifying fibromyxoid tumor in left maxillo-ethmoid sinus with intracranial extension in a child. ⁶¹	Ghosal N...Gopal S	27345437	2016
32	Non-epithelial tumors of the larynx: a single institution review. ⁶¹	Karatayli-Ozgursoy S...Best SR	27178524	2016
33	Ossifying Fibromyxoid Tumor: An Update. ⁶¹	Bakiratharajan D...Rekhi B	27028395	2016
34	Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis. ⁶¹	Schneider N...Thway K	26732302	2016
35	Histologic diagnosis of ossifying fibromyxoid tumor: 2 cases in the past 20 Years. ⁶¹	Hernandez-Godoy J...Rosell AA	26076876	2015
36	Ossifying fibromyxoid tumor: a clinicopathologic analysis of 26 subcutaneous tumors with emphasis on differential diagnosis and prognostic factors. ⁶¹	Atanaskova Mesinkovska N...Billings SD	25950586	2015
37	Diagnostically Challenging Epithelioid Soft Tissue Tumors. ⁶¹	James AW...Dry SM	26297059	2015
38	Ossifying fibromyxoid tumor: report of a case with cytomorphologic description. ⁶¹	Ahmed OI...Salih ZT	25914177	2015
39	Pediatric low-grade fibromyxoid sarcoma mimicking ossifying fibromyxoid tumor: adding to the diagnostic spectrum of soft tissue tumors with a bony shell. ⁶¹	Thway K...Fisher C	25532939	2015
40	Atypical ossifying fibromyxoid tumor unusually located in the mediastinum: report of a case showing mosaic loss of INI-1 expression. ⁶¹	Tajima S...Koda K	25973116	2015
41	Ossifying fibromyxoid tumor (OFMT) - A rare cause of a painful thumb. ⁶¹	Sharma K...Harper RD	25603305	2015
42	Atypical ossifying fibromyxoid tumor. ⁶¹	Lagergren E...Powell MS	25105387	2014
43	Ossifying fibromyxoid tumor of the breast mimicking fibroadenoma: a case report and differential diagnoses. ⁶¹	Asirvatham JR...Morgenstern NJ	25076299	2014
44	Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. ⁶¹	Petscavage-Thomas JM...Murphey MD	25019435	2014
45	Ossifying fibromyxoid tumor metastatic to the thyroid: a case report and review of the literature. ⁶¹	Lastra RR...Huang JH	24932821	2014
46	[Ossifying fibromyxoid tumor in the mandible: a case report]. ⁶¹	Ren D...Chen Y	24881220	2014
47	Ossifying fibromyxoid tumor presenting EP400-PHF1 fusion gene. ⁶¹	Endo M...Oda Y	23806526	2013
48	PHF1 rearrangements in ossifying fibromyxoid tumors of soft parts: A fluorescence in situ hybridization study of 41 cases with emphasis on the malignant variant. ⁶¹	Graham RP...Folpe AL	23887158	2013
49	Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature. ⁶¹	Ohta K...Kamata N	23800162	2013
50	Imaging findings of ossifying fibromyxoid tumor with histopathological correlation: A case report. ⁶¹	Ideta S...Naito M	23599783	2013

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Genes for Ossifying Fibromyxoid Tumor

Genes related to Ossifying Fibromyxoid Tumor (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	13.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	11.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	ZC3H7B	Zinc Finger CCCH-Type Containing 7B	Protein Coding	8.52	DISEASES inferred ¹⁵
4	MEAF6	MYST/Esa1 Associated Factor 6	Protein Coding	7.99	DISEASES inferred ¹⁵
5	PHF1	PHD Finger Protein 1	Protein Coding	7.91	DISEASES inferred ¹⁵
6	DES	Desmin	Protein Coding	7.84	GeneCards inferred via : Publications (show sections)
7	S100B	S100 Calcium Binding Protein B	Protein Coding	7.69	GeneCards inferred via : Publications (show sections)
8	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	7.49	GeneCards inferred via : Publications (show sections)
9	VIM	Vimentin	Protein Coding	7.49	GeneCards inferred via : Publications (show sections)
10	EP400	E1A Binding Protein P400	Protein Coding	7.49	DISEASES inferred ¹⁵
11	CCNB3	Cyclin B3	Protein Coding	7.42	DISEASES inferred ¹⁵
12	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	7.35	DISEASES inferred ¹⁵
13	S100A1	S100 Calcium Binding Protein A1	Protein Coding	7.14	GeneCards inferred via : Publications (show sections)
14	MBTD1	Mbt Domain Containing 1	Protein Coding	6.62	DISEASES inferred ¹⁵

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Variations for Ossifying Fibromyxoid Tumor

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Expression for Ossifying Fibromyxoid Tumor

Search GEO for disease gene expression data for Ossifying Fibromyxoid Tumor.

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Pathways for Ossifying Fibromyxoid Tumor

Pathways related to Ossifying Fibromyxoid Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	11.75	VIM MUC1 DES ACTC1
2	Striated Muscle Contraction ¹ ⁶⁵	10.66	VIM DES ACTC1

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GO Terms for Ossifying Fibromyxoid Tumor

Cellular components related to Ossifying Fibromyxoid Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.4	ZC3H7B VIM S100B S100A1 PHF1 MUC1
2	NuA4 histone acetyltransferase complex	GO:0035267	8.96	MEAF6 EP400

Biological processes related to Ossifying Fibromyxoid Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament organization	GO:0045109	9.26	VIM DES
2	chromatin organization	GO:0006325	9.26	PHF1 MEAF6 MBTD1 EP400
3	histone H2A acetylation	GO:0043968	9.16	MEAF6 EP400
4	muscle filament sliding	GO:0030049	8.8	VIM DES ACTC1

Molecular functions related to Ossifying Fibromyxoid Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	S100 protein binding	GO:0044548	8.62	S100B S100A1

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Sources for Ossifying Fibromyxoid Tumor

¹ BioSystems

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⁵² NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

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⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia