MCID: OST004
MIFTS: 38

Osteitis Fibrosa

Categories: Bone diseases, Endocrine diseases, Nephrological diseases

Aliases & Classifications for Osteitis Fibrosa

MalaCards integrated aliases for Osteitis Fibrosa:

Name: Osteitis Fibrosa 12 54 15 17
Osteitis Fibrosa Cystica 44 70
Osteitis Fibrosa Cystica Generalisata 12
Von Recklinghausen's Bone Disease 12
Hyperparathyroid Bone Disease 12
Osteitis Fibrosa Disseminata 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3341
MeSH 44 D010002
NCIt 50 C34875
SNOMED-CT 67 190451000
UMLS 70 C0016063 C0029405

Summaries for Osteitis Fibrosa

Disease Ontology : 12 A bone resorption disease that has material basis in hyperparathyroidism which results in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary : Osteitis Fibrosa, also known as osteitis fibrosa cystica, is related to pseudohypoparathyroidism, type ib and mccune-albright syndrome. An important gene associated with Osteitis Fibrosa is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are G alpha (s) signalling events and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, thyroid and bone marrow, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Wikipedia : 73 Osteitis fibrosa cystica (/ˌɒstiˈaɪtɪs faɪˈbroʊsə ˈsɪstɪkə/ OS-tee-AY-tis fy-BROH-sə SIS-tik-ə), is a... more...

Related Diseases for Osteitis Fibrosa

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 pseudohypoparathyroidism, type ib 31.9 PTH GNAS BGLAP
2 mccune-albright syndrome 31.9 GNAS FGF23 BGLAP
3 adenoma 30.6 PTH GNAS CDC73 CASR
4 bone giant cell tumor 30.4 PTH CALCA
5 pseudohypoparathyroidism 30.4 PTH GNAS CALCA BGLAP
6 hyperparathyroidism 2 with jaw tumors 30.4 CDC73 CASR
7 giant cell reparative granuloma 30.4 PTH CALCA
8 clear cell adenoma 30.2 PTH CDC73
9 mammary paget's disease 30.2 PTH CALCA BGLAP
10 benign giant cell tumor 30.2 FGF23 CALCA BGLAP
11 hyperparathyroidism 30.2 PTH FGF23 CDC73 CASR CALCA BGLAP
12 parathyroid adenoma 30.2 PTH GNAS CDC73 CASR CALCA BGLAP
13 renal osteodystrophy 29.9 PTH FGF23 CASR CALCA BGLAP
14 parathyroid carcinoma 29.9 PTH CDC73 CASR CALCA
15 osteomalacia 29.9 PTH FGF23 CASR CALCA BGLAP
16 rickets 29.9 PTH FGF23 CASR BGLAP
17 osteogenic sarcoma 29.9 PTH IL6 IL11 BGLAP
18 bone resorption disease 29.9 PTH IL6 FGF23 CALCA BGLAP
19 hyperthyroidism 29.8 PTH GNAS CALCA BGLAP
20 uremia 29.8 PTH IL6 CASR B2M
21 hypophosphatemia 29.8 PTH FGF23 BGLAP
22 primary hyperparathyroidism 29.7 PTH IL6 FGF23 CDC73 CASR CALCA
23 calciphylaxis 29.7 PTH FGF23 CASR
24 calcinosis 29.7 GNAS FGF23 CALCA
25 secondary hyperparathyroidism 29.5 PTH FGF23 CASR CALCA BGLAP B2M
26 fibrous dysplasia 29.4 GNAS FGF23 CDC73 CALCA BGLAP
27 hyperphosphatemia 29.3 PTH GNAS FGF23 CASR BGLAP
28 bone disease 29.1 PTH IL6 IL11 FGF23 CASR CALCA
29 end stage renal disease 28.9 PTH IL6 FGF23 CASR B2M
30 kidney disease 28.9 PTH IL6 FGF23 CASR BGLAP B2M
31 chronic kidney disease 28.3 PTH IL6 GNAS FGF23 CASR BGLAP
32 osteoporosis 28.0 PTH IL6 IL11 GNAS FGF23 CASR
33 bone inflammation disease 11.2
34 bullous impetigo 10.3 IL6 CALCA
35 impetigo 10.3 IL6 CALCA
36 acute cholangitis 10.3 IL6 CALCA
37 bursitis 10.3 IL6 CALCA
38 malignant ovarian brenner tumor 10.3 PTH CALCA
39 substernal goiter 10.3 PTH CALCA
40 dental pulp disease 10.3 IL6 BGLAP
41 vitamin d-dependent rickets 10.3 PTH BGLAP
42 solitary bone cyst 10.2
43 endemic goiter 10.2 PTH CALCA
44 erysipelas 10.2 IL6 CALCA
45 epilepsy, familial temporal lobe, 2 10.2 IL6 IL11
46 decubitus ulcer 10.2 IL6 CALCA
47 suppurative thyroiditis 10.2 PTH CALCA
48 giant papillary conjunctivitis 10.2 IL6 IL11
49 papillary conjunctivitis 10.2 IL6 IL11
50 chronic recurrent multifocal osteomyelitis 10.2 IL6 BGLAP

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to Osteitis Fibrosa

Symptoms & Phenotypes for Osteitis Fibrosa

MGI Mouse Phenotypes related to Osteitis Fibrosa:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.86 B2M BGLAP CASR CDC73 FGF23 GNAS
2 hematopoietic system MP:0005397 9.76 B2M BGLAP CASR CDC73 FGF23 GNAS
3 immune system MP:0005387 9.56 B2M BGLAP CASR CDC73 FGF23 GNAS
4 skeleton MP:0005390 9.17 BGLAP CASR CDC73 FGF23 GNAS IL6

Drugs & Therapeutics for Osteitis Fibrosa

Search Clinical Trials , NIH Clinical Center for Osteitis Fibrosa

Cochrane evidence based reviews: osteitis fibrosa cystica

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

The Foundational Model of Anatomy Ontology organs/tissues related to Osteitis Fibrosa:

19
Bone

MalaCards organs/tissues related to Osteitis Fibrosa:

40
Bone, Thyroid, Bone Marrow, Eye, Skin

Publications for Osteitis Fibrosa

Articles related to Osteitis Fibrosa:

(show top 50) (show all 708)
# Title Authors PMID Year
1
Management of calcium and bone abnormalities in hemodialysis patients. 61 54
15490408 2004
2
[Selected parameters of bone metabolism in hemodialyzed and peritoneally dialyzed patients]. 54 61
11398592 2000
3
Renal ostodystrophy during the developing stage of maintenance dialysis in Transylvania. Early development of periarticular calcifications and beta 2 microglobulin amyloidosis in spite of a relatively good prevention of secondary hyperparathyroidism. 54 61
11490527 1998
4
Symptomatic hypercalcemia in a diabetic patient undergoing continuous ambulatory peritoneal dialysis: value of bone biopsy in the diagnosis and management. 61 54
7485141 1995
5
[Clinical study of total parathyroidectomy and autotransplantation for secondary hyperparathyroidism]. 61 54
1474716 1992
6
Correction to: Osteitis fibrosa cystica von Recklinghausen. 61
33772726 2021
7
Osteitis fibrosa cystica von Recklinghausen. 61
33555577 2021
8
Old and New Drugs for the Management of Bone Disorders in CKD. 61
33386480 2021
9
Treatment of pathological fractures due to brown tumours in a patient with hyperparathyroidism and lack of parafibromin expression - A case report. 61
33204800 2020
10
Differences in Primary Hyperparathyroidism Between Pre- and Postmenopausal Women in India. 61
33685668 2020
11
Skeletal abnormalities in Hypoparathyroidism and in Primary Hyperparathyroidism. 61
33200346 2020
12
Osteoblastic differentiation of bone marrow mesenchymal stem cells in uremic rats. 61
32826057 2020
13
Radiologic Manifestation of Bone Involvement in Primary Hyperparathyroidism: Prevalence and Clinical Significance in a Southern European Series. 61
33471703 2020
14
Quantitative histomorphometric analysis of halved iliac crest bone biopsies yield comparable ROD diagnosis as full 7.5mm wide samples. 61
32485361 2020
15
Osteitis Fibrosa Cystica. 61
32995697 2020
16
Osteitis Fibrosa Cystica Caused by Hyperparathyroidism Shown on 18F-NaF PET/CT. 61
32453081 2020
17
Warfarin-induced impairment of bone material quality in a patient undergoing maintenance hemodialysis: A case report. 61
32569210 2020
18
RADIOLOGICAL MANIFESTATION OF BONE INVOLVEMENT IN PRIMARY HYPERPARATHYROIDISM: PREVALENCE AND CLINICAL SIGNIFICANCE IN A SOUTHERN EUROPEAN SERIES. 61
32407658 2020
19
Osteitis Fibrosa Cystica. 61
32160666 2020
20
Multifocal osteolytic lesions of jaw as a road map to diagnosis of brown tumor of hyperparathyroidism: A rare case report with review of literature. 61
32189907 2020
21
Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic haemodialysis patients. 61
30980579 2020
22
A Novel Variant in the Calcium-Sensing Receptor Associated with Familial Hypocalciuric Hypercalcemia and Low-to-Normal PTH. 61
33062349 2020
23
Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO. 61
32756862 2020
24
Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO. 61
31967202 2020
25
Radiological diagnostic features of uremic leontiasis ossea: a case report. 61
31559846 2020
26
Brown tumor due to primary hyperparathyroidism resulting in acute paraparesis: Case report and literature review. 61
33194288 2020
27
A complex case of brown tumors as initial manifestation of primary hyperparathyroidism in a young female. 61
31942141 2019
28
Classical complications of primary hyperparathyroidism. 61
30665547 2018
29
Expansive renal osteitis fibrosa: a case report. 61
29725779 2018
30
Brown tumor of multiple facial bones associated with primary hyperparathyroidism: A clinical case report. 61
30113484 2018
31
Osteitis fibrosa cystica. 61
29415233 2018
32
Bone histomorphometry in the evaluation of osteomalacia. 61
29955631 2018
33
Osteitis fibrosa cystica masquerading as bone neoplasm. 61
29735505 2018
34
Suspected Malignant Lesion of the Hip Resolves after Parathyroidectomy: Osteitis Fibrosa Cystica (or Brown Tumor): A Case Report. 61
29996036 2018
35
Refractory hyperparathyroidism with a T3 bony lesion-differential diagnoses. 61
29593877 2018
36
[Osteitis fibrosa cystica in the hand: a rare, but important differential diagnosis]. 61
29590703 2018
37
Oral and maxillofacial manifestations of chronic kidney disease-mineral and bone disorder: a multicenter retrospective study. 61
29104033 2018
38
Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency. 61
29850279 2018
39
[Fragility Fractures in Hemodialysis Patients. Uremic bone disease:the effect of medical treatment until now.] 61
30049912 2018
40
Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism. 61
28900835 2017
41
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. 61
29386822 2017
42
Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism. 61
28554885 2017
43
A patient with a history of breast cancer and multiple bone lesions: a case report. 61
28476174 2017
44
The use of bone turnover markers in chronic kidney disease-mineral and bone disorders. 61
28429547 2017
45
Osteitis fibrosa cystica. 61
27238197 2017
46
Management of adynamic bone disease in chronic kidney disease: A brief review. 61
29067232 2016
47
We Use Too Much Vitamin D in Hemodialysis Patients. 61
27075415 2016
48
A COMPARATIVE ANALYSIS OF THE INITIAL EAST EUROPEAN CENTER EXPERIENCE WITH A WESTERN HIGH-VOLUME CENTER FOR OPEN MINIMALLY INVASIVE PARATHYROIDECTOMY (OMIP) AS TREATMENT OF PRIMARY HYPERPARATHYROIDISM. 61
31149104 2016
49
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. 61
27030464 2016
50
Multilevel brown tumors of the spine in a patient with severe secondary hyperparathyroidism A case report and review of the literature. 61
27064191 2016

Variations for Osteitis Fibrosa

Expression for Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

Pathways for Osteitis Fibrosa

GO Terms for Osteitis Fibrosa

Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 PTH IL6 IL11 FGF23 CALCA BGLAP
2 endoplasmic reticulum lumen GO:0005788 9.46 IL6 FGF23 BGLAP B2M
3 extracellular region GO:0005576 9.23 PTH IL6 IL11 GNAS FGF23 CALCA

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.86 IL6 IL11 FGF23 CASR
2 skeletal system development GO:0001501 9.69 PTH GNAS BGLAP
3 response to drug GO:0042493 9.67 PTH GNAS BGLAP B2M
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.63 PTH GNAS CALCA
5 cellular calcium ion homeostasis GO:0006874 9.61 PTH CASR CALCA
6 response to cadmium ion GO:0046686 9.57 PTH B2M
7 negative regulation of neurogenesis GO:0050768 9.55 IL6 B2M
8 vasodilation GO:0042311 9.54 CASR CALCA
9 regulation of bone mineralization GO:0030500 9.52 FGF23 BGLAP
10 response to vitamin D GO:0033280 9.49 PTH BGLAP
11 negative regulation of bone resorption GO:0045779 9.48 IL6 CALCA
12 negative regulation of hormone secretion GO:0046888 9.4 IL11 FGF23
13 response to fibroblast growth factor GO:0071774 9.32 PTH CASR
14 phosphate ion homeostasis GO:0055062 9.26 PTH FGF23
15 cellular protein metabolic process GO:0044267 9.26 IL6 FGF23 CALCA B2M
16 response to parathyroid hormone GO:0071107 9.16 PTH GNAS
17 cellular response to vitamin D GO:0071305 8.8 FGF23 CASR BGLAP

Molecular functions related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 IL6 IL11 FGF23

Sources for Osteitis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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