Aliases & Classifications for Osteitis Fibrosa

MalaCards integrated aliases for Osteitis Fibrosa:

Name: Osteitis Fibrosa 12 55 15
Osteitis Fibrosa Cystica 44 73
Osteitis Fibrosa Cystica Generalisata 12
Von Recklinghausen's Bone Disease 12
Hyperparathyroid Bone Disease 12
Osteitis Fibrosa Disseminata 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3341
MeSH 44 D010002
NCIt 50 C34875
UMLS 73 C0029405

Summaries for Osteitis Fibrosa

Disease Ontology : 12 A bone resorption disease that has material basis in hyperparathyroidism which results in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary : Osteitis Fibrosa, also known as osteitis fibrosa cystica, is related to mccune-albright syndrome and pseudohypoparathyroidism, type ib. An important gene associated with Osteitis Fibrosa is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. The drugs Etidronic acid and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and kidney.

Wikipedia : 76 Osteitis fibrosa cystica (/ˌɒstiˈaɪtɪs faɪˈbroʊsə ˈsɪstɪkə/ OS-tee-AY-tis fy-BROH-sə SIS-tik-ə), is a... more...

Related Diseases for Osteitis Fibrosa

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome 32.3 BGLAP GNAS
2 pseudohypoparathyroidism, type ib 31.4 BGLAP GNAS PTH
3 renal osteodystrophy 31.4 BGLAP CALCA CASR PTH
4 giant cell tumor 30.5 BGLAP CALCA
5 osteomalacia 30.4 BGLAP CALCA CASR
6 calciphylaxis 30.3 CASR PTH
7 hyperparathyroidism 30.2 BGLAP CALCA CASR PTH
8 primary hyperparathyroidism 30.0 BGLAP CALCA CASR PTH
9 pseudohypoparathyroidism 30.0 BGLAP GNAS PTH
10 parathyroid adenoma 29.8 BGLAP CALCA CASR PTH
11 secondary hyperparathyroidism of renal origin 29.6 BGLAP CALCA CASR PTH
12 rickets 29.6 BGLAP PTH
13 osteoporosis 28.9 BGLAP CALCA CASR PTH
14 bone disease 28.5 B2M BGLAP CALCA CASR PTH
15 monostotic fibrous dysplasia 11.2
16 adenoma 10.5
17 osteoporosis, juvenile 10.5 BGLAP CALCA
18 axial osteomalacia 10.5 BGLAP PTH
19 extraskeletal chondroma 10.5 BGLAP PTH
20 nontoxic goiter 10.4 BGLAP CALCA
21 fibrogenesis imperfecta ossium 10.4 CALCA PTH
22 impaired renal function disease 10.4 BGLAP PTH
23 ischemic bone disease 10.3 BGLAP PTH
24 metaphyseal chondrodysplasia, jansen type 10.3 CALCA PTH
25 hemiplegia 10.3 BGLAP CALCA
26 chronic pyelonephritis 10.3 B2M CALCA
27 uremic neuropathy 10.3 B2M PTH
28 multiple endocrine neoplasia, type iia 10.3 CALCA PTH
29 hypocalciuric hypercalcemia, familial, type iii 10.3 CASR PTH
30 amyloid tumor 10.3 B2M CALCA
31 hypoparathyroidism, familial isolated 10.3 CASR PTH
32 ovarian cystic teratoma 10.2 B2M CALCA
33 idiopathic hypercalciuria 10.2 BGLAP CASR
34 hypocalciuric hypercalcemia, familial, type ii 10.2 CASR PTH
35 thyroid gland disease 10.2 CALCA PTH
36 familial hypocalciuric hypercalcemia 10.2 CASR PTH
37 thyroiditis 10.2
38 osteonecrosis 10.2 BGLAP PTH
39 fanconi-like syndrome 10.2 B2M CASR
40 osseous heteroplasia, progressive 10.2 BGLAP GNAS
41 hypophosphatemia 10.2 BGLAP PTH
42 osteofibrous dysplasia 10.1 BGLAP GNAS
43 pseudopseudohypoparathyroidism 10.1 GNAS PTH
44 hyperparathyroidism 2 with jaw tumors 10.1
45 solitary bone cyst 10.1
46 metal metabolism disorder 10.0 GNAS PTH
47 hypophosphatasia, adult 10.0 BGLAP CALCA PTH
48 glucocorticoid-induced osteoporosis 10.0 BGLAP CALCA PTH
49 bone resorption disease 10.0 BGLAP CALCA PTH
50 bone remodeling disease 10.0 BGLAP CALCA PTH

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to Osteitis Fibrosa

Symptoms & Phenotypes for Osteitis Fibrosa

Drugs & Therapeutics for Osteitis Fibrosa

Drugs for Osteitis Fibrosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 2, Phase 3 7414-83-7, 2809-21-4 3305
2 Bone Density Conservation Agents Phase 2, Phase 3
3 calcium channel blockers Phase 2, Phase 3
4 Calcium, Dietary Phase 2, Phase 3
5 Diphosphonates Phase 2, Phase 3
6 Risedronate Sodium Phase 2, Phase 3 115436-72-1
7 Hormone Antagonists Phase 3,Phase 2,Phase 1
8 Hormones Phase 3,Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
10
Testolactone Approved, Investigational Phase 2 968-93-4 13769
11
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
12
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
13
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
14 Antineoplastic Agents, Hormonal Phase 2
15 Aromatase Inhibitors Phase 2,Phase 1
16 Estrogens Phase 2,Phase 1
17 Estrogen Antagonists Phase 2,Phase 1
18 Steroid Synthesis Inhibitors Phase 2,Phase 1
19 Phosphodiesterase 4 Inhibitors Phase 1, Phase 2
20 Estrogen Receptor Antagonists Phase 2
21
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
22
Histamine Approved, Investigational 75614-87-8, 51-45-6 774
23
Histamine Phosphate 51-74-1 65513
24 Neurotransmitter Agents

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3 risedronate;placebo;risedronate;placebo
2 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3 Pegvisomant
3 TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE Unknown status NCT01791842 Phase 2 Tocilizumab;Placebo
4 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
5 Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001728 Phase 2 Fosamax (Alendronate)
6 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
7 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome Recruiting NCT02743377 Phase 1, Phase 2
8 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
9 Denosumab Treatment for Fibrous Dysplasia Enrolling by invitation NCT03571191 Phase 2 Denosumab;Denosumab;Denosumab
10 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
11 Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome Completed NCT00001973
12 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
13 Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
14 Natural History of Cherubism Observational Study Completed NCT01916772
15 Histamine Responsiveness in McCune-Albright Syndrome Completed NCT00318097
16 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Recruiting NCT02868645 Not Applicable
17 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
18 Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry Recruiting NCT03231644
19 Genetic and Functional Analysis of Cherubism Recruiting NCT01630447
20 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Not yet recruiting NCT03520153

Search NIH Clinical Center for Osteitis Fibrosa

Cochrane evidence based reviews: osteitis fibrosa cystica

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

The Foundational Model of Anatomy Ontology organs/tissues related to Osteitis Fibrosa:

19
Bone

MalaCards organs/tissues related to Osteitis Fibrosa:

41
Bone, Kidney, Bone Marrow, Brain, Thyroid, T Cells, Skin

Publications for Osteitis Fibrosa

Articles related to Osteitis Fibrosa:

(show top 50) (show all 157)
# Title Authors Year
1
Osteitis Fibrosa Cystica. ( 29415233 )
2018
2
Osteitis fibrosa cystica masquerading as bone neoplasm. ( 29735505 )
2018
3
Expansive renal osteitis fibrosa: a case report. ( 29725779 )
2018
4
Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency. ( 29850279 )
2018
5
Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism. ( 28900835 )
2017
6
Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism. ( 28554885 )
2017
7
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. ( 29386822 )
2017
8
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. ( 27030464 )
2016
9
Osteitis fibrosa cystica. ( 27238197 )
2016
10
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. ( 26881146 )
2016
11
Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review. ( 25511968 )
2015
12
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. ( 25828738 )
2015
13
Brown tumors: severe osteitis fibrosa cystica. ( 25939949 )
2015
14
Osteitis fibrosa cystica in a domestic young cat. ( 28491388 )
2015
15
Osteitis fibrosa cystica in primary hyperparathyroidism. ( 26261355 )
2015
16
Osteitis fibrosa cystica mistaken for malignant disease. ( 23799171 )
2013
17
Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy. ( 23365170 )
2013
18
Hyperparathyroidism-jaw tumour syndrome detected by aggressive generalized osteitis fibrosa cystica. ( 23858315 )
2013
19
Successful treatment of osteitis fibrosa cystica from primary hyperparathyroidism. ( 23259108 )
2012
20
Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica. ( 21584419 )
2011
21
A rare case of primary hyperparathyroidism and osteitis fibrosa cystica. ( 20919975 )
2010
22
Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. ( 18635661 )
2008
23
Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report. ( 18702368 )
2008
24
Visual vignette. Osteitis fibrosa cystica. ( 18753115 )
2008
25
Osteitis fibrosa cystica and secondary hyperparathyroidism in multiple myeloma. ( 17062009 )
2007
26
Oxyphilic cell adenoma of parathyroid resulting in primary hyperparathyroidism and osteitis fibrosa cystica--a case report. ( 17001919 )
2006
27
Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. ( 15168133 )
2004
28
Osteitis fibrosa cystica, coeliac disease and Turner syndrome. A case report. ( 15285529 )
2004
29
Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. ( 12490858 )
2002
30
Radiology quiz case 2: metastatic calcifications of the middle and external ear and osteitis fibrosa of the temporal bones as a result of secondary hyperparathyroidism. ( 11926927 )
2002
31
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. ( 11743611 )
2002
32
Effect of parathyroid adenoma resection on bone density in primary hyperparathyroidism and osteitis fibrosa cystica. ( 11688767 )
2001
33
Tc99m-sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease. ( 11701666 )
2001
34
False positive 99mTc sestamibi scans in patients with osteitis fibrosa cystica and brown tumours. ( 11716445 )
2001
35
Images in haematology. Osteitis fibrosa cystica generalisata with adult T-cell leukaemia: a case report. ( 11054056 )
2000
36
Osteitis fibrosa cystica generalizata with adult T-cell leukaemia: a case report. ( 10606900 )
1999
37
22-Oxacalcitriol ameliorates high-turnover bone and marked osteitis fibrosa in rats with slowly progressive nephritis. ( 10594779 )
1999
38
Osteitis fibrosa cystica with renal parathyroid hormone resistance: a review of pseudohypoparathyroidism with insight into calcium homeostasis. ( 9637471 )
1998
39
Marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9506717 )
1998
40
NPS R-568 halts or reverses osteitis fibrosa in uremic rats. ( 9461105 )
1998
41
Comment on marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9768702 )
1998
42
Osteitis fibrosa: treatment trends. ( 9543904 )
1998
43
Osteitis fibrosa cystica and chronic renal failure. ( 9158318 )
1997
44
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism. ( 9015472 )
1996
45
Intravenous calcitriol can increase bone mass in hemodialysis patients with osteitis fibrosa. ( 7565429 )
1995
46
Inhibition of 1,25(OH)2D production by hypercalcemia in osteitis fibrosa cystica: influence on parathyroid hormone secretion and hungry bone disease. ( 8274876 )
1993
47
Pseudohypoparathyroidism with osteitis fibrosa cystica: direct demonstration of skeletal responsiveness to parathyroid hormone in cells cultured from bone. ( 8427051 )
1993
48
Paraplegia due to osteitis fibrosa secondary to primary hyperparathyroidism: report of a case. ( 8292854 )
1993
49
Case management of the anemic patient: epoetin alfa--focus on osteitis fibrosa. ( 8285805 )
1993
50
Osteitis fibrosa cystica simulating metastatic tumor. An almost-forgotten relationship. ( 8249919 )
1993

Variations for Osteitis Fibrosa

Expression for Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

GO Terms for Osteitis Fibrosa

Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 B2M BGLAP CALCA GNAS PTH

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.86 CALCA CASR GNAS PTH
2 skeletal system development GO:0001501 9.58 BGLAP GNAS PTH
3 ossification GO:0001503 9.57 BGLAP CASR
4 response to nutrient levels GO:0031667 9.55 BGLAP PTH
5 bone development GO:0060348 9.54 BGLAP GNAS
6 activation of adenylate cyclase activity GO:0007190 9.52 CALCA GNAS
7 response to cadmium ion GO:0046686 9.51 B2M PTH
8 cellular calcium ion homeostasis GO:0006874 9.5 CALCA CASR PTH
9 vasodilation GO:0042311 9.49 CALCA CASR
10 response to vitamin D GO:0033280 9.48 BGLAP PTH
11 positive regulation of ossification GO:0045778 9.46 CALCA PTH
12 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.43 GNAS PTH
13 cellular response to vitamin D GO:0071305 9.37 BGLAP CASR
14 response to fibroblast growth factor GO:0071774 9.26 CASR PTH
15 response to parathyroid hormone GO:0071107 9.16 GNAS PTH
16 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.13 CALCA GNAS PTH
17 response to drug GO:0042493 8.92 B2M BGLAP GNAS PTH

Sources for Osteitis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....