MCID: OST004
MIFTS: 42

Osteitis Fibrosa

Categories: Bone diseases, Endocrine diseases

Aliases & Classifications for Osteitis Fibrosa

MalaCards integrated aliases for Osteitis Fibrosa:

Name: Osteitis Fibrosa 12 55 15
Osteitis Fibrosa Cystica 44 73
Osteitis Fibrosa Cystica Generalisata 12
Von Recklinghausen's Bone Disease 12
Hyperparathyroid Bone Disease 12
Osteitis Fibrosa Disseminata 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3341
MeSH 44 D010002
NCIt 50 C34875
SNOMED-CT 68 84727000

Summaries for Osteitis Fibrosa

Disease Ontology : 12 A bone resorption disease that has material basis in hyperparathyroidism which results in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary : Osteitis Fibrosa, also known as osteitis fibrosa cystica, is related to mccune-albright syndrome and pseudohypoparathyroidism, type ib. An important gene associated with Osteitis Fibrosa is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. The drugs Etidronic acid and Risedronate Sodium have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and thyroid.

Wikipedia : 76 Osteitis fibrosa cystica (/�?�?sti�?aɪtɪs faɪ�?bro�?s�? �?sɪstɪk�?/ OS-tee-AY-tis fy-BROH-s�?... more...

Related Diseases for Osteitis Fibrosa

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome 32.4 BGLAP GNAS
2 pseudohypoparathyroidism, type ib 31.9 BGLAP GNAS PTH
3 hyperparathyroidism 31.0 BGLAP CALCA CASR PTH
4 primary hyperparathyroidism 30.8 BGLAP CALCA CASR PTH
5 parathyroid adenoma 30.6 BGLAP CALCA CASR PTH
6 giant cell tumor 30.6 BGLAP CALCA
7 pseudohypoparathyroidism 30.5 BGLAP GNAS PTH
8 osteomalacia 30.4 BGLAP CALCA CASR PTH
9 secondary hyperparathyroidism of renal origin 30.4 BGLAP CALCA CASR PTH
10 rickets 30.3 BGLAP PTH
11 calciphylaxis 30.2 CASR PTH
12 renal osteodystrophy 30.1 BGLAP CALCA CASR PTH
13 bone disease 29.9 B2M BGLAP CALCA CASR PTH
14 osteoporosis 29.8 BGLAP CALCA CASR PTH
15 uremia 29.5 B2M CASR PTH
16 monostotic fibrous dysplasia 11.4
17 adenoma 10.7
18 bone inflammation disease 10.5
19 solitary bone cyst 10.3
20 hyperparathyroidism 2 with jaw tumors 10.2
21 thyroid gland disease 10.2 CALCA PTH
22 axial osteomalacia 10.1 BGLAP PTH
23 extraskeletal chondroma 10.1 BGLAP PTH
24 nontoxic goiter 10.1 BGLAP CALCA
25 fibrogenesis imperfecta ossium 10.1 CALCA PTH
26 impaired renal function disease 10.1 BGLAP PTH
27 ischemic bone disease 10.1 BGLAP PTH
28 hemiplegia 10.1 BGLAP CALCA
29 metaphyseal chondrodysplasia, jansen type 10.1 CALCA PTH
30 amyloid tumor 10.1 B2M CALCA
31 chronic pyelonephritis 10.1 B2M CALCA
32 multiple endocrine neoplasia, type iia 10.1 CALCA PTH
33 hypocalciuric hypercalcemia, familial, type i 10.1 CASR PTH
34 uremic neuropathy 10.1 B2M PTH
35 hypocalciuric hypercalcemia, familial, type ii 10.1 CASR PTH
36 hypocalciuric hypercalcemia, familial, type iii 10.1 CASR PTH
37 paget disease of bone 3 10.1
38 thyroid cancer, nonmedullary, 1 10.1
39 myeloma, multiple 10.1
40 ameloblastoma 10.1
41 calcinosis 10.1
42 liposarcoma 10.1
43 turner syndrome 10.1
44 paraplegia 10.1
45 dwarfism 10.1
46 precocious puberty 10.1
47 hypoparathyroidism, familial isolated 10.1 CASR PTH
48 endocrine organ benign neoplasm 10.1 CALCA PTH
49 idiopathic hypercalciuria 10.1 BGLAP CASR
50 osteonecrosis 10.1 BGLAP PTH

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to Osteitis Fibrosa

Symptoms & Phenotypes for Osteitis Fibrosa

Drugs & Therapeutics for Osteitis Fibrosa

Drugs for Osteitis Fibrosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 2, Phase 3 7414-83-7, 2809-21-4 3305
2 Risedronate Sodium Phase 2, Phase 3 115436-72-1
3 Calcium, Dietary Phase 2, Phase 3
4 calcium channel blockers Phase 2, Phase 3
5 Diphosphonates Phase 2, Phase 3
6 Bone Density Conservation Agents Phase 2, Phase 3
7 Hormones Phase 3,Phase 2,Phase 1
8 Hormone Antagonists Phase 3,Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
10
Testolactone Approved, Investigational Phase 2 968-93-4 13769
11
Alendronate Approved Phase 2 66376-36-1, 121268-17-5 2088
12
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
13
Fulvestrant Approved, Investigational Phase 2 129453-61-8 17756771 104741
14
Denosumab Approved Phase 2 615258-40-7
15 Estrogens Phase 2,Phase 1
16 Aromatase Inhibitors Phase 2,Phase 1
17 Antineoplastic Agents, Hormonal Phase 2
18 Estrogen Antagonists Phase 2,Phase 1
19 Steroid Synthesis Inhibitors Phase 2,Phase 1
20 Estrogen Receptor Antagonists Phase 2,Phase 1
21 Phosphodiesterase 4 Inhibitors Phase 1, Phase 2
22
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
23
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
24
Histamine Phosphate 51-74-1 65513
25 Neurotransmitter Agents
26 insulin
27 Insulin, Globin Zinc

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3 risedronate;placebo;risedronate;placebo
2 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3 Pegvisomant
3 TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE Unknown status NCT01791842 Phase 2 Tocilizumab;Placebo
4 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
5 Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001728 Phase 2 Fosamax (Alendronate)
6 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
7 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome Recruiting NCT02743377 Phase 1, Phase 2
8 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
9 Denosumab Treatment for Fibrous Dysplasia Enrolling by invitation NCT03571191 Phase 2 Denosumab;Denosumab;Denosumab
10 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
11 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Completed NCT02868645 Not Applicable
12 Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome Completed NCT00001973
13 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
14 Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
15 Natural History of Cherubism Observational Study Completed NCT01916772
16 Histamine Responsiveness in McCune-Albright Syndrome Completed NCT00318097
17 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
18 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Recruiting NCT03520153
19 Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry Recruiting NCT03231644
20 Genetic and Functional Analysis of Cherubism Recruiting NCT01630447

Search NIH Clinical Center for Osteitis Fibrosa

Cochrane evidence based reviews: osteitis fibrosa cystica

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

MalaCards organs/tissues related to Osteitis Fibrosa:

41
Bone, Kidney, Thyroid, T Cells, Skin, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Osteitis Fibrosa:

19
Bone

Publications for Osteitis Fibrosa

Articles related to Osteitis Fibrosa:

(show top 50) (show all 168)
# Title Authors Year
1
Osteitis Fibrosa Cystica. ( 29415233 )
2018
2
Osteitis fibrosa cystica masquerading as bone neoplasm. ( 29735505 )
2018
3
Expansive renal osteitis fibrosa: a case report. ( 29725779 )
2018
4
Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency. ( 29850279 )
2018
5
Suspected Malignant Lesion of the Hip Resolves after Parathyroidectomy: Osteitis Fibrosa Cystica (or Brown Tumor): A Case Report. ( 29996036 )
2018
6
Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism. ( 28900835 )
2017
7
Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism. ( 28554885 )
2017
8
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. ( 29386822 )
2017
9
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. ( 27030464 )
2016
10
Osteitis fibrosa cystica. ( 27238197 )
2016
11
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. ( 26881146 )
2016
12
Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review. ( 25511968 )
2015
13
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. ( 25828738 )
2015
14
Brown tumors: severe osteitis fibrosa cystica. ( 25939949 )
2015
15
Osteitis fibrosa cystica in a domestic young cat. ( 28491388 )
2015
16
Osteitis fibrosa cystica in primary hyperparathyroidism. ( 26261355 )
2015
17
Osteitis fibrosa cystica mistaken for malignant disease. ( 23799171 )
2013
18
Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy. ( 23365170 )
2013
19
Hyperparathyroidism-jaw tumour syndrome detected by aggressive generalized osteitis fibrosa cystica. ( 23858315 )
2013
20
Successful treatment of osteitis fibrosa cystica from primary hyperparathyroidism. ( 23259108 )
2012
21
Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica. ( 21584419 )
2011
22
A rare case of primary hyperparathyroidism and osteitis fibrosa cystica. ( 20919975 )
2010
23
Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. ( 18635661 )
2008
24
Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report. ( 18702368 )
2008
25
Visual vignette. Osteitis fibrosa cystica. ( 18753115 )
2008
26
Osteitis fibrosa cystica and secondary hyperparathyroidism in multiple myeloma. ( 17062009 )
2007
27
Oxyphilic cell adenoma of parathyroid resulting in primary hyperparathyroidism and osteitis fibrosa cystica--a case report. ( 17001919 )
2006
28
Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. ( 15168133 )
2004
29
Osteitis fibrosa cystica, coeliac disease and Turner syndrome. A case report. ( 15285529 )
2004
30
Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. ( 12490858 )
2002
31
Radiology quiz case 2: metastatic calcifications of the middle and external ear and osteitis fibrosa of the temporal bones as a result of secondary hyperparathyroidism. ( 11926927 )
2002
32
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. ( 11743611 )
2002
33
Effect of parathyroid adenoma resection on bone density in primary hyperparathyroidism and osteitis fibrosa cystica. ( 11688767 )
2001
34
Tc99m-sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease. ( 11701666 )
2001
35
False positive 99mTc sestamibi scans in patients with osteitis fibrosa cystica and brown tumours. ( 11716445 )
2001
36
Images in haematology. Osteitis fibrosa cystica generalisata with adult T-cell leukaemia: a case report. ( 11054056 )
2000
37
Osteitis fibrosa cystica generalizata with adult T-cell leukaemia: a case report. ( 10606900 )
1999
38
22-Oxacalcitriol ameliorates high-turnover bone and marked osteitis fibrosa in rats with slowly progressive nephritis. ( 10594779 )
1999
39
Osteitis fibrosa cystica with renal parathyroid hormone resistance: a review of pseudohypoparathyroidism with insight into calcium homeostasis. ( 9637471 )
1998
40
Marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9506717 )
1998
41
NPS R-568 halts or reverses osteitis fibrosa in uremic rats. ( 9461105 )
1998
42
Comment on marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9768702 )
1998
43
Osteitis fibrosa: treatment trends. ( 9543904 )
1998
44
Osteitis fibrosa cystica and chronic renal failure. ( 9158318 )
1997
45
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism. ( 9015472 )
1996
46
Intravenous calcitriol can increase bone mass in hemodialysis patients with osteitis fibrosa. ( 7565429 )
1995
47
Inhibition of 1,25(OH)2D production by hypercalcemia in osteitis fibrosa cystica: influence on parathyroid hormone secretion and hungry bone disease. ( 8274876 )
1993
48
Pseudohypoparathyroidism with osteitis fibrosa cystica: direct demonstration of skeletal responsiveness to parathyroid hormone in cells cultured from bone. ( 8427051 )
1993
49
Paraplegia due to osteitis fibrosa secondary to primary hyperparathyroidism: report of a case. ( 8292854 )
1993
50
Case management of the anemic patient: epoetin alfa--focus on osteitis fibrosa. ( 8285805 )
1993

Variations for Osteitis Fibrosa

Expression for Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

GO Terms for Osteitis Fibrosa

Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 B2M BGLAP CALCA GNAS PTH

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.85 CALCA CASR GNAS PTH
2 skeletal system development GO:0001501 9.58 BGLAP GNAS PTH
3 ossification GO:0001503 9.56 BGLAP CASR
4 response to nutrient levels GO:0031667 9.54 BGLAP PTH
5 bone development GO:0060348 9.52 BGLAP GNAS
6 bone mineralization GO:0030282 9.51 BGLAP PTH
7 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.5 CALCA GNAS PTH
8 activation of adenylate cyclase activity GO:0007190 9.49 CALCA GNAS
9 response to cadmium ion GO:0046686 9.48 B2M PTH
10 response to vitamin D GO:0033280 9.46 BGLAP PTH
11 vasodilation GO:0042311 9.43 CALCA CASR
12 cellular calcium ion homeostasis GO:0006874 9.43 CALCA CASR PTH
13 cellular response to vitamin D GO:0071305 9.37 BGLAP CASR
14 response to fibroblast growth factor GO:0071774 9.16 CASR PTH
15 response to parathyroid hormone GO:0071107 8.96 GNAS PTH
16 response to drug GO:0042493 8.92 B2M BGLAP GNAS PTH

Sources for Osteitis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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