MCID: OST004
MIFTS: 40

Osteitis Fibrosa

Categories: Bone diseases, Endocrine diseases

Aliases & Classifications for Osteitis Fibrosa

MalaCards integrated aliases for Osteitis Fibrosa:

Name: Osteitis Fibrosa 12 55 15 17
Osteitis Fibrosa Cystica 44 72
Osteitis Fibrosa Cystica Generalisata 12
Von Recklinghausen's Bone Disease 12
Hyperparathyroid Bone Disease 12
Osteitis Fibrosa Disseminata 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3341
MeSH 44 D010002
NCIt 50 C34875
SNOMED-CT 68 84727000
UMLS 72 C0016063 C0029405

Summaries for Osteitis Fibrosa

Disease Ontology : 12 A bone resorption disease that has material basis in hyperparathyroidism which results in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary : Osteitis Fibrosa, also known as osteitis fibrosa cystica, is related to mccune-albright syndrome and pseudohypoparathyroidism, type ib. An important gene associated with Osteitis Fibrosa is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. The drugs Parathyroid hormone and Calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and thyroid.

Wikipedia : 75 Osteitis fibrosa cystica (/EOE'stiE^aEatEas faEaE^broESsET E^sEastEakET/ OS-tee-AY-tis fy-BROH-sET... more...

Related Diseases for Osteitis Fibrosa

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome 32.9 GNAS BGLAP
2 pseudohypoparathyroidism, type ib 32.1 PTH GNAS BGLAP
3 giant cell tumor 31.0 CALCA BGLAP
4 bone resorption disease 30.6 PTH CALCA BGLAP
5 hyperparathyroidism 30.6 PTH CASR CALCA BGLAP
6 primary hyperparathyroidism 30.4 PTH CASR CALCA BGLAP
7 osteonecrosis 30.3 PTH BGLAP
8 hypophosphatemia 30.3 PTH BGLAP
9 parathyroid adenoma 30.3 PTH CASR CALCA BGLAP
10 calciphylaxis 30.2 PTH CASR
11 bone disease 30.1 PTH CASR CALCA BGLAP
12 rickets 30.1 PTH BGLAP
13 pseudohypoparathyroidism 30.0 PTH GNAS BGLAP
14 uremia 30.0 PTH CASR
15 fibrous dysplasia 30.0 GNAS CALCA BGLAP
16 renal osteodystrophy 29.9 PTH CASR CALCA BGLAP
17 parathyroid carcinoma 29.9 PTH CASR CALCA
18 osteomalacia 29.9 PTH CASR CALCA BGLAP
19 hyperthyroidism 29.6 GNAS BGLAP
20 hyperphosphatemia 29.3 PTH GNAS CASR
21 osteoporosis 28.8 PTH IL11 CASR CALCA BGLAP
22 bone inflammation disease 11.3
23 adenoma 10.8
24 secondary hyperparathyroidism 10.6
25 nontoxic goiter 10.3 CALCA BGLAP
26 myeloma, multiple 10.3
27 kidney disease 10.3
28 end stage renal failure 10.3
29 solitary bone cyst 10.3
30 thyroid gland disease 10.3 PTH CALCA
31 axial osteomalacia 10.3 PTH BGLAP
32 extraskeletal chondroma 10.3 PTH BGLAP
33 hyperparathyroidism 2 with jaw tumors 10.3
34 neurofibromatosis, type iv, of riccardi 10.3
35 bone mineral density quantitative trait locus 8 10.3
36 bone mineral density quantitative trait locus 15 10.3
37 bone giant cell tumor 10.3
38 chronic kidney disease 10.3
39 fibrogenesis imperfecta ossium 10.2 PTH CALCA
40 impaired renal function disease 10.2 PTH BGLAP
41 hemiplegia 10.2 CALCA BGLAP
42 ischemic bone disease 10.2 PTH BGLAP
43 paget's disease of bone 10.2 CALCA BGLAP
44 cloacogenic carcinoma 10.2 PTH CALCA
45 metaphyseal chondrodysplasia, jansen type 10.2 PTH CALCA
46 multiple endocrine neoplasia, type iia 10.1 PTH CALCA
47 endocrine organ benign neoplasm 10.1 PTH CALCA
48 endosteal hyperostosis, autosomal dominant 10.1
49 thyroid cancer, nonmedullary, 1 10.1
50 chondrosarcoma 10.1

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to Osteitis Fibrosa

Symptoms & Phenotypes for Osteitis Fibrosa

Drugs & Therapeutics for Osteitis Fibrosa

Drugs for Osteitis Fibrosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Hormones Phase 4
4 Calcium, Dietary Phase 4
5 Bone Density Conservation Agents Phase 4
6
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
7
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
8 Maxacalcitol Investigational 103909-75-7
9 Trace Elements
10 Micronutrients
11 Vitamins
12 Hydroxycholecalciferols
13 Protective Agents
14 Dermatologic Agents
15 Calciferol
16 Nutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Study of Efficacy and Safety of Calcium Sensing Receptor in Chronic Dialysis Patients Completed NCT02056730 Phase 4 calcium sensing receptor agonist
2 The Association of Serum Sclerostin Levels,Echocardiographic Parameters, Arteriovenous Fistula Thrombosis and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Unknown status NCT01382966
3 Evaluation of Quality of Life in Patients Undergoing Parathyroidectomy Completed NCT00905866
4 A Study of Maintenance Therapy After Intravenous Maxacalcitol for Secondary Hyperparathyroidism Completed NCT00828347 1.0 μg/day Alfacalcidol;0.25 μg/day Alfacalcidol
5 Circulating microRNA Signatures in Primary Hyperparathyroidism Recruiting NCT03931109
6 Bone Metabolism and Cardiovascular Risk After Kidney Transplant in Adult Patients Active, not recruiting NCT02751099
7 Characterization of Patients With Idiopathic Hypoparathyroidism, Autosomal Dominant Hypocalcaemia and Pseudohypoparathyroidism Active, not recruiting NCT02551120

Search NIH Clinical Center for Osteitis Fibrosa

Cochrane evidence based reviews: osteitis fibrosa cystica

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

MalaCards organs/tissues related to Osteitis Fibrosa:

41
Bone, Kidney, Thyroid, Testes, Bone Marrow, T Cells, Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Osteitis Fibrosa:

19
Bone

Publications for Osteitis Fibrosa

Articles related to Osteitis Fibrosa:

(show top 50) (show all 686)
# Title Authors PMID Year
1
Management of calcium and bone abnormalities in hemodialysis patients. 9 38
15490408 2004
2
[Selected parameters of bone metabolism in hemodialyzed and peritoneally dialyzed patients]. 9 38
11398592 2000
3
Renal ostodystrophy during the developing stage of maintenance dialysis in Transylvania. Early development of periarticular calcifications and beta 2 microglobulin amyloidosis in spite of a relatively good prevention of secondary hyperparathyroidism. 9 38
11490527 1998
4
Symptomatic hypercalcemia in a diabetic patient undergoing continuous ambulatory peritoneal dialysis: value of bone biopsy in the diagnosis and management. 9 38
7485141 1995
5
[Clinical study of total parathyroidectomy and autotransplantation for secondary hyperparathyroidism]. 9 38
1474716 1992
6
Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic haemodialysis patients. 38
30980579 2019
7
Classical complications of primary hyperparathyroidism. 38
30665547 2018
8
Expansive renal osteitis fibrosa: a case report. 38
29725779 2018
9
Brown tumor of multiple facial bones associated with primary hyperparathyroidism: A clinical case report. 38
30113484 2018
10
Osteitis fibrosa cystica. 38
29415233 2018
11
Bone histomorphometry in the evaluation of osteomalacia. 38
29955631 2018
12
Osteitis fibrosa cystica masquerading as bone neoplasm. 38
29735505 2018
13
Suspected Malignant Lesion of the Hip Resolves after Parathyroidectomy: Osteitis Fibrosa Cystica (or Brown Tumor): A Case Report. 38
29996036 2018
14
Refractory hyperparathyroidism with a T3 bony lesion-differential diagnoses. 38
29593877 2018
15
[Osteitis fibrosa cystica in the hand: a rare, but important differential diagnosis]. 38
29590703 2018
16
[Fragility Fractures in Hemodialysis Patients. Uremic bone disease:the effect of medical treatment until now.] 38
30049912 2018
17
Oral and maxillofacial manifestations of chronic kidney disease-mineral and bone disorder: a multicenter retrospective study. 38
29104033 2018
18
Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency. 38
29850279 2018
19
Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism. 38
28900835 2017
20
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. 38
29386822 2017
21
Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism. 38
28554885 2017
22
A patient with a history of breast cancer and multiple bone lesions: a case report. 38
28476174 2017
23
The use of bone turnover markers in chronic kidney disease-mineral and bone disorders. 38
28429547 2017
24
Osteitis fibrosa cystica. 38
27238197 2017
25
Management of adynamic bone disease in chronic kidney disease: A brief review. 38
29067232 2016
26
We Use Too Much Vitamin D in Hemodialysis Patients. 38
27075415 2016
27
A COMPARATIVE ANALYSIS OF THE INITIAL EAST EUROPEAN CENTER EXPERIENCE WITH A WESTERN HIGH-VOLUME CENTER FOR OPEN MINIMALLY INVASIVE PARATHYROIDECTOMY (OMIP) AS TREATMENT OF PRIMARY HYPERPARATHYROIDISM. 38
31149104 2016
28
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. 38
27030464 2016
29
Multilevel brown tumors of the spine in a patient with severe secondary hyperparathyroidism A case report and review of the literature. 38
27064191 2016
30
Bone histomorphometry and indicators of bone and mineral metabolism in wait-listed dialysis patients. 38
26833298 2016
31
Changing bone patterns with progression of chronic kidney disease. 38
26806832 2016
32
Jaw tumor in primary hyperparathyroidism is not always a brown tumor. 38
27252751 2016
33
Resection of a large ectopic parathyroid adenoma: A case report. 38
27078868 2016
34
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. 38
26881146 2016
35
Multiple 'Brown Tumors' Masquerading as Metastatic Bone Disease. 38
26848420 2015
36
Osteitis fibrosa cystica in primary hyperparathyroidism. 38
26261355 2015
37
Vitamin D and Clinical Outcomes in Dialysis. 38
26424141 2015
38
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. 38
25828738 2015
39
A rare case describing catastrophic destruction of the whole skeleton caused by severe hyperparathyroidism. 38
26491001 2015
40
Osteitis fibrosa cystica in a domestic young cat. 38
28491388 2015
41
Unusual presentation of primary hyperparathyroidism: report of three cases. 38
26179753 2015
42
Hyperparathyroidism and Bone Health. 38
26105042 2015
43
Brown tumors: severe osteitis fibrosa cystica. 38
25939949 2015
44
Skeletal lesions in primary hyperparathyroidism. 38
25798829 2015
45
Aneurysmal bone cyst does not hinder the success of kidney transplantation. A case report. 38
25514989 2015
46
Expansive jaw lesions in chronic kidney disease: review of the literature and a report of two cases. 38
25547821 2015
47
Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review. 38
25511968 2015
48
Maxillofacial brown tumors in secondary hyperparathyroidism: A case report and literature review. 38
25657758 2014
49
Surgical management of primary hyperparathyroidism in older adults. 38
25113865 2014
50
Brown tumor of the spine in patients with primary hyperparathyroidism. 38
24921845 2014

Variations for Osteitis Fibrosa

Expression for Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

GO Terms for Osteitis Fibrosa

Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 PTH IL11 GNAS CALCA BGLAP

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.84 PTH GNAS CASR CALCA
2 response to drug GO:0042493 9.67 PTH GNAS BGLAP
3 ossification GO:0001503 9.55 CASR BGLAP
4 skeletal system development GO:0001501 9.54 PTH GNAS BGLAP
5 response to nutrient levels GO:0031667 9.52 PTH BGLAP
6 bone development GO:0060348 9.51 GNAS BGLAP
7 activation of adenylate cyclase activity GO:0007190 9.46 GNAS CALCA
8 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.43 PTH GNAS CALCA
9 response to vitamin D GO:0033280 9.4 PTH BGLAP
10 cellular response to vitamin D GO:0071305 9.32 CASR BGLAP
11 bone mineralization GO:0030282 9.18 BGLAP
12 cellular calcium ion homeostasis GO:0006874 9.16 PTH CASR
13 vasodilation GO:0042311 9.13 CASR
14 response to fibroblast growth factor GO:0071774 8.96 PTH CASR
15 response to parathyroid hormone GO:0071107 8.62 PTH GNAS

Sources for Osteitis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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