Aliases & Classifications for Osteoarthritis

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 38 12 76 25 29 55 6 43 3 44 15 63 40
Degenerative Joint Disease 12 25 29
Osteoarthrosis 12 25 15
Degenerative Polyarthritis 25 73
Hypertrophic Arthritis 12 25
Arthropathy 25 73
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 25
Osteoarthrosis Deformans 73
Arthritis, Degenerative 25
Degenerative Arthritis 12
Kashin-Beck Disease 73
Oa 25

Characteristics:


Classifications:



External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 35 715.3
MeSH 44 D010003
SNOMED-CT via HPO 69 263681008 258211005 239872002

Summaries for Osteoarthritis

MedlinePlus : 43 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint No single test can diagnose osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteoarthritis, also known as degenerative joint disease, is related to cartilage disease and epiphyseal dysplasia, multiple, 1, and has symptoms including tremor, joint stiffness and arthralgia. An important gene associated with Osteoarthritis is FRZB (Frizzled Related Protein), and among its related pathways/superpathways are Degradation of the extracellular matrix and Endochondral Ossification. The drugs Hyaluronic acid and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are abnormality of pelvic girdle bone morphology and hip osteoarthritis

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

Genetics Home Reference : 25 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. It is sometimes called degenerative joint disease or “wear and tear” arthritis. It most frequently occurs in the hands, hips, and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling, and can result in disability.

PubMed Health : 63 About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age.If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 76 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Related Diseases for Osteoarthritis

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)
# Related Disease Score Top Affiliating Genes
1 cartilage disease 32.3 ACAN COL2A1 COMP
2 epiphyseal dysplasia, multiple, 1 32.1 ACAN COMP MATN3
3 pseudoachondroplasia 32.0 ACAN COMP MATN3
4 epiphyseal dysplasia, multiple, 5 31.8 COMP MATN3
5 coxa vara 30.9 COL2A1 MMP13
6 transient arthritis 30.5 ACAN COMP
7 degenerative disc disease 30.5 ACAN ASPN GDF5
8 osteochondritis dissecans 30.4 ACAN COMP MATN3 MMP13
9 multiple epiphyseal dysplasia 30.3 ACAN COL2A1 COMP MATN3
10 spondyloepiphyseal dysplasia congenita 30.1 ASPN COL2A1 COMP MMP13
11 bone inflammation disease 29.8 ACAN COL2A1 COMP MMP13
12 bone disease 29.8 ACAN COL2A1 GDF5 MMP13
13 brachydactyly 29.8 COL2A1 COMP GDF5
14 glioblastoma 29.5 GAS5 H19 HOTAIR MEG3
15 osteogenic sarcoma 29.3 GAS5 H19 HOTAIR MEG3 PACERR
16 myeloma, multiple 29.2 GAS5 H19 HOTAIR MEG3
17 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 12.7
18 multicentric osteolysis, nodulosis, and arthropathy 12.5
19 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.5
20 osteoarthritis with mild chondrodysplasia 12.4
21 arthropathy, progressive pseudorheumatoid, of childhood 12.4
22 neurogenic arthropathy 12.4
23 behcet's syndrome arthropathy 12.2
24 transient arthropathy 12.1
25 multicentric osteolysis-nodulosis-arthropathy spectrum 12.1
26 short stature-advanced bone age-early-onset osteoarthritis syndrome 12.0
27 arthropathy, erosive 12.0
28 progeria-associated arthropathy 11.9
29 loeys-dietz syndrome 3 11.9
30 chondrocalcinosis 2 11.9
31 familial osteochondritis dissecans 11.9
32 czech dysplasia 11.7
33 arthritis 11.5
34 rheumatoid arthritis 11.5
35 microphthalmia with limb anomalies 11.4
36 otospondylomegaepiphyseal dysplasia, autosomal recessive 11.4
37 developmental dysplasia of the hip 1 11.4
38 hemochromatosis, type 2a 11.4
39 anophthalmos with limb anomalies 11.4
40 spondylosis 11.4
41 esophageal atresia 11.3
42 myhre syndrome 11.3
43 cinca syndrome 11.3
44 hemochromatosis type 2 11.3
45 chondrocalcinosis 1 11.3
46 wild type abeta2m amyloidosis 11.3
47 beukes hip dysplasia 11.2
48 alkaptonuria 11.2
49 spondyloepiphyseal dysplasia tarda, x-linked 11.2
50 ehlers-danlos syndrome 11.2

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Dysthymic Disorder Esophagitis
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

Human phenotypes related to Osteoarthritis:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of pelvic girdle bone morphology 32 HP:0002644
2 hip osteoarthritis 32 HP:0008843

UMLS symptoms related to Osteoarthritis:


tremor, joint stiffness, arthralgia, angina pectoris, back pain, sciatica, equilibration disorder, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Osteoarthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.17 ASPN COL2A1 COMP FRZB GDF5 MATN3

Drugs & Therapeutics for Osteoarthritis

PubMedHealth treatment related to Osteoarthritis: 63

There are many different suggestions and recommendations for treating osteoarthritis, but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible.There are two different types of therapies: Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy.The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle-strengthening exercises could help people with knee osteoarthritis. Other treatment options include massage, acupuncture, TENS, medicinal baths or orthopedic insoles.Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation. There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 713)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
3
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
4
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
5
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
6
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-84-3 187
7
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
8
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 1302 156391
9
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2 161796-78-7, 119141-88-7 4594 9579578
10
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3416-24-8 439213
11
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
12
Chitosan Approved Phase 4,Not Applicable 9012-76-4 71853
13
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 378-44-9 9782
14
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
15
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 66635-83-4, 74103-06-3 3826
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
17
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 1177-87-3
18
Iron Approved Phase 4,Phase 1,Phase 2,Not Applicable 7439-89-6 23925
19
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
20
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
21
Hyoscyamine Approved Phase 4,Not Applicable 101-31-5 64692
22
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
23
Dalteparin Approved Phase 4,Phase 3 9005-49-6
24
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
25
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
26
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
27
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
28
Rivaroxaban Approved Phase 4,Phase 3,Not Applicable 366789-02-8
29
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
30
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
31
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
32
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
33
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 27203-92-5 33741
34
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2921-57-5
35
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
36
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 302-25-0
37
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
38
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 15307-86-5 3033
39
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
40
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
41
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Not Applicable 148553-50-8 5486971
42
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 71125-38-7 54677470 5281106
43
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
44
Indian frankincense Approved, Experimental, Investigational Phase 4,Phase 3,Not Applicable
45
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
46 tannic acid Approved Phase 4,Phase 3,Phase 1,Not Applicable
47
Cobalt Approved, Experimental Phase 4,Phase 3,Phase 2,Not Applicable 7440-48-4 104729
48
Parecoxib Approved Phase 4,Phase 3,Not Applicable 198470-84-7
49
Aminocaproic Acid Approved, Investigational Phase 4,Phase 2,Not Applicable 60-32-2 564
50
Chromium Approved Phase 4,Phase 3,Phase 2,Not Applicable 7440-47-3 27668

Interventional clinical trials:

(show top 50) (show all 3949)
# Name Status NCT ID Phase Drugs
1 Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02949466 Phase 4 Triamcinolone
2 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
3 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
4 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
5 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
6 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
7 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
8 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
9 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
10 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
11 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
12 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
13 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
14 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
15 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
16 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
17 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
18 A Safety Study of Hylan GF-20 to Treat Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
19 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
20 Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
21 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
22 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
23 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
24 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle Unknown status NCT02627859 Phase 4
25 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
26 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
27 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
28 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
29 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
30 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
31 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
32 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
33 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
34 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
35 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
36 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
37 Artelon Metatarsophalangeal (MTP) Spacer Unknown status NCT01028469 Phase 4
38 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
39 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
40 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
41 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
42 Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin
43 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
44 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
45 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
46 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
47 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
48 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine
49 Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty Unknown status NCT02624856 Phase 4 Liposomal bupivacaine;Bupivacaine plus dexamethasone
50 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem�-derived chondrocytes for treatment of osteochondral defects
AlloStem�, adipose-derived mesenchymal stem cells combined with allograft bone for bone grafting
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel�, autologous cultured chondrocytes for treatment of cartilage defects
CARTISTEM�, mesenchymal stem cells for treatment of osteoarthritis
Chondrocell�, bone marrow-derived mesenchymal stem cells for osteoarthritis
Chondrogen�, mesenchymal stem cells for meniscus regeneration and knee osteoarthritis prevention
HiQCell�, adipose-derived stromal vascular fraction for osteoarthritis
JACC�, cultured cartilage for chondral lesion
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem�, adipose-derived mesenchymal stem cells for degenerative arthritis
StempeucelOA�, mesenchymal stem cells for treatment of osteoarthritis
Trinity� Evolution�, mesenchymal stem cells with osteoprogenitors for musculoskeletal defects
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem� 4D20.8, NCr-fac Progenitor PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem�) PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel�) PMIDs: 17515233 17590152 16510814
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 10102814 14673997 19530993 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC�) PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel�) PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity� Evolution�) PMIDs: 21056860 20508015

Cochrane evidence based reviews: osteoarthritis

Genetic Tests for Osteoarthritis

Genetic tests related to Osteoarthritis:

# Genetic test Affiliating Genes
1 Osteoarthritis 29 FRZB
2 Degenerative Joint Disease 29

Anatomical Context for Osteoarthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteoarthritis:

19
Joint

MalaCards organs/tissues related to Osteoarthritis:

41
Bone, Testes, Bone Marrow, Skin, Brain, T Cells, Skeletal Muscle
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
2 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
3 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
4 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
5 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
6 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
7 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
8 Cartilage Temporomandibular Joint Affected by disease
9 Bone Vertebrae Affected by disease

Publications for Osteoarthritis

Articles related to Osteoarthritis:

(show top 50) (show all 4227)
# Title Authors Year
1
The prevalence of depression and insomnia symptoms among patients with rheumatoid arthritis and osteoarthritis in Poland: a case control study. ( 30286609 )
2019
2
An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. ( 30539776 )
2019
3
Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway. ( 30551410 )
2019
4
Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model. ( 30551412 )
2019
5
Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives. ( 30551490 )
2019
6
ACY-1215 exhibits anti-inflammatory and chondroprotective effects in human osteoarthritis chondrocytes via inhibition of STAT3 and NF-κB signaling pathways. ( 30551507 )
2019
7
Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes. ( 30461544 )
2019
8
Ortho-Biologics for Osteoarthritis. ( 30466718 )
2019
9
Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model. ( 30365059 )
2019
10
Casticin protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes. ( 30391743 )
2019
11
Osteoarthritis following meniscus and ligament injury: insights from translational studies and animal models. ( 30394938 )
2019
12
Imaging of Osteoarthritis by Conventional Radiography, MR Imaging, PET-Computed Tomography, and PET-MR Imaging. ( 30420217 )
2019
13
Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis. ( 30292837 )
2019
14
Mitigation of Articular Cartilage Degeneration and Subchondral Bone Sclerosis in Osteoarthritis Progression Using Low-Intensity Ultrasound Stimulation. ( 30322672 )
2019
15
Restoration Effect and Tribological Behavior of Hyaluronic Acid Reinforced with Graphene Oxide in Osteoarthritis. ( 30327006 )
2019
16
Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. ( 30352228 )
2019
17
Is muscle strength in a painful limb affected by knee pain status of the contralateral limb? - Data from the Osteoarthritis Initiative. ( 30240905 )
2019
18
Body weight support through a walking cane in inexperienced users with knee osteoarthritis. ( 30286316 )
2019
19
Staircase-evoked Pain May be More Sensitive Than Traditional Pain Assessments in Discriminating Analgesic Effects: A Randomized, Placebo-controlled Trial of Naproxen in Patients With Osteoarthritis of the Knee. ( 30222614 )
2019
20
Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression. ( 30145794 )
2019
21
Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis-like phenotype in temporomandibular joint via activation of β-catenin and FGF signaling. ( 30070692 )
2019
22
Baseline knee joint effusion and medial femoral bone marrow edema, in addition to MRI-based T2 relaxation time and texture measurements of knee cartilage, can help predict incident total knee arthroplasty 4-7 years later: data from the Osteoarthritis Initiative. ( 29961091 )
2019
23
Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks. ( 29080354 )
2018
24
Extracorporeal shockwave therapy for the treatment of knee osteoarthritis: A retrospective study. ( 29979441 )
2018
25
Recent advances in hyaluronic acid based therapy for osteoarthritis. ( 29450666 )
2018
26
Functionality in Middle-Aged and Older Overweight and Obese Individuals with Knee Osteoarthritis. ( 29973574 )
2018
27
An Update on Unloading Knee Braces in the Treatment of Unicompartmental Knee Osteoarthritis from the Last 10 Years: A Literature Review. ( 29978048 )
2018
28
Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? ( 29980827 )
2018
29
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
30
Short-Term Outcomes in Treatment of Knee Osteoarthritis With 4 Bone Marrow Concentrate Injections. ( 29977117 )
2018
31
The role of skeletal muscle in the pathophysiology and management of knee osteoarthritis. ( 29444285 )
2018
32
The knitting community-based trial for older women with osteoarthritis of the hands: design and rationale of a randomized controlled trial. ( 29444664 )
2018
33
Are Carpal Tunnel Syndrome and Regional Degenerative Osteoarthritis Linked? Results of a Case-Control Study. ( 29409410 )
2018
34
Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: a systematic review. ( 29446485 )
2018
35
Cationic poly-l-lysine-encapsulated melanin nanoparticles as efficient photoacoustic agents targeting to glycosaminoglycans for the early diagnosis of articular cartilage degeneration in osteoarthritis. ( 29972184 )
2018
36
A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis. ( 29922449 )
2018
37
The presence of cardiovascular disease does not modify the weak impact obesity has on health-related quality of life in patients with hip osteoarthritis in the KHOALA cohort. ( 28242173 )
2018
38
Early morphologic changes in trapeziometacarpal joint bones with osteoarthritis. ( 29981379 )
2018
39
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study. ( 28365812 )
2018
40
Usefulness of dual-energy computed tomography for the evaluation of psoriatic arthritis accompanied by knee osteoarthritis. ( 29974970 )
2018
41
Osteoarthritis-Like Changes in Bardet-Biedl Syndrome Mutant Ciliopathy Mice (<i>Bbs1</i><sup>M<i>390</i>R/M<i>390</i>R</sup>): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation. ( 29971011 )
2018
42
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. ( 29968759 )
2018
43
Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. ( 29445972 )
2018
44
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis. ( 29356574 )
2018
45
Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging. ( 29451138 )
2018
46
Osteoarthritis-related walking disability and arterial stiffness-results from a cross-sectional study. ( 29975013 )
2018
47
Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling. ( 29978613 )
2018
48
Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis. ( 29561445 )
2018
49
Development and persistence of suspected neuropathic pain after total knee arthroplasty in individuals with osteoarthritis. ( 29452296 )
2018
50
Oromandibular Dystonia-Related Temporomandibular Joint Osteoarthritis: A Case History Report. ( 29723311 )
2018