Aliases & Classifications for Osteoarthritis

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 39 12 77 26 30 56 6 44 45 15 41 17 3 64
Degenerative Joint Disease 12 26 30
Osteoarthrosis 12 26 15
Degenerative Polyarthritis 26 74
Hypertrophic Arthritis 12 26
Arthropathy 26 74
Oa 26 3
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 26
Osteoarthrosis Deformans 74
Arthritis, Degenerative 26
Degenerative Arthritis 12
Kashin-Beck Disease 74

Characteristics:


Classifications:



External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 36 715.3
MeSH 45 D010003
SNOMED-CT via HPO 70 239872002 258211005 263681008

Summaries for Osteoarthritis

MedlinePlus : 44 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint No single test can diagnose osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteoarthritis, also known as degenerative joint disease, is related to cartilage disease and epiphyseal dysplasia, multiple, 1, and has symptoms including tremor, joint stiffness and arthralgia. An important gene associated with Osteoarthritis is KCNK15-AS1 (KCNK15 And WISP2 Antisense RNA 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Endochondral Ossification. The drugs Hyaluronic acid and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are abnormality of pelvic girdle bone morphology and hip osteoarthritis

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

Genetics Home Reference : 26 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or “wear and tear” arthritis. It occurs most frequently in the hands, hips, and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

PubMed Health : 64 About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age.If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 77 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Related Diseases for Osteoarthritis

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 671)
# Related Disease Score Top Affiliating Genes
1 cartilage disease 32.6 ACAN COL2A1 COMP
2 epiphyseal dysplasia, multiple, 1 32.4 ACAN COMP MATN3
3 pseudoachondroplasia 32.3 ACAN COMP MATN3
4 epiphyseal dysplasia, multiple, 5 32.1 COMP MATN3
5 coxa vara 31.2 COL2A1 MMP13
6 transient arthritis 30.7 ACAN COMP
7 osteochondritis dissecans 30.6 ACAN COMP MATN3 MMP13
8 degenerative disc disease 30.6 ACAN ASPN GDF5
9 multiple epiphyseal dysplasia 30.5 ACAN COL2A1 COMP MATN3
10 bone disease 30.4 ACAN COL2A1 GDF5 MMP13
11 spondyloepiphyseal dysplasia congenita 30.3 ASPN COL2A1 COMP MMP13
12 bone inflammation disease 30.1 ACAN COL2A1 COMP MMP13
13 brachydactyly 30.0 COL2A1 COMP GDF5
14 glioblastoma 29.4 GAS5 H19 HOTAIR MEG3
15 myeloma, multiple 29.2 GAS5 H19 HOTAIR MEG3
16 osteogenic sarcoma 29.1 GAS5 H19 HOTAIR MEG3 PACERR
17 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 12.7
18 multicentric osteolysis, nodulosis, and arthropathy 12.6
19 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.6
20 arthropathy, progressive pseudorheumatoid, of childhood 12.5
21 osteoarthritis with mild chondrodysplasia 12.5
22 neurogenic arthropathy 12.4
23 behcet's syndrome arthropathy 12.2
24 transient arthropathy 12.2
25 multicentric osteolysis-nodulosis-arthropathy spectrum 12.2
26 arthropathy, erosive 12.1
27 short stature-advanced bone age-early-onset osteoarthritis syndrome 12.1
28 loeys-dietz syndrome 3 12.0
29 chondrocalcinosis 2 12.0
30 familial osteochondritis dissecans 11.9
31 czech dysplasia 11.7
32 jaccoud's syndrome 11.5
33 arthritis 11.5
34 rheumatoid arthritis 11.5
35 microphthalmia with limb anomalies 11.5
36 otospondylomegaepiphyseal dysplasia, autosomal recessive 11.5
37 developmental dysplasia of the hip 1 11.4
38 hemochromatosis, type 2a 11.4
39 anophthalmos with limb anomalies 11.4
40 spondylosis 11.4
41 esophageal atresia 11.4
42 myhre syndrome 11.3
43 wild type abeta2m amyloidosis 11.3
44 chondrocalcinosis 1 11.3
45 cinca syndrome 11.3
46 hemochromatosis type 2 11.3
47 ehlers-danlos syndrome 11.2
48 alkaptonuria 11.2
49 spondyloepiphyseal dysplasia tarda, x-linked 11.2
50 congenital dislocation of the patella 11.2

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Dysthymic Disorder Esophagitis
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

Human phenotypes related to Osteoarthritis:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of pelvic girdle bone morphology 33 HP:0002644
2 hip osteoarthritis 33 HP:0008843

UMLS symptoms related to Osteoarthritis:


tremor, joint stiffness, arthralgia, angina pectoris, back pain, sciatica, equilibration disorder, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Osteoarthritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 COL2A1 COMP FRZB GDF5 MATN3 MMP13

Drugs & Therapeutics for Osteoarthritis

PubMedHealth treatment related to Osteoarthritis: 64

There are many different suggestions and recommendations for treating osteoarthritis, but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible.There are two different types of therapies: Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy.The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle-strengthening exercises could help people with knee osteoarthritis. Other treatment options include massage, acupuncture, TENS, medicinal baths or orthopedic insoles.Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation. There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 730)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
3
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
4
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
5
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-84-3 187
6
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
7
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-41-2 439260
8
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
9
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 156391 1302
10
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
11
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
12
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3416-24-8 439213
13
Chitosan Approved Phase 4,Not Applicable 9012-76-4 71853
14
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 66635-83-4, 74103-06-3 3826
15
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 378-44-9 9782
16
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 1177-87-3
19
Iron Approved, Experimental Phase 4,Phase 1,Phase 2,Not Applicable 7439-89-6, 15438-31-0 23925 27284
20
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
21
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 71273 175805
22
Hyoscyamine Approved Phase 4,Not Applicable 101-31-5 64692
23
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
24
Rivaroxaban Approved Phase 4,Phase 3,Not Applicable 366789-02-8
25
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
26
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
27
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
28
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
29
Dalteparin Approved Phase 4,Phase 3 9005-49-6
30
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
31
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
32
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
33
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
34
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 27203-92-5 33741
35
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 302-25-0
36
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
37
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2921-57-5
38
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
39
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 15307-86-5 3033
40
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
41
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
42
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Not Applicable 148553-50-8 5486971
43
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 71125-38-7 5281106 54677470
44
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
45
Indian frankincense Approved, Experimental, Investigational Phase 4,Phase 3,Not Applicable
46
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
47
tannic acid Approved Phase 4,Phase 3,Phase 1,Not Applicable 1401-55-4
48
Cobalt Approved, Experimental Phase 4,Phase 3,Phase 2,Not Applicable 7440-48-4 104729
49
Parecoxib Approved Phase 4,Phase 3,Not Applicable 198470-84-7
50
Aminocaproic Acid Approved, Investigational Phase 4,Phase 2,Not Applicable 60-32-2 564

Interventional clinical trials:

(show top 50) (show all 4059)
# Name Status NCT ID Phase Drugs
1 Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02949466 Phase 4 Triamcinolone
2 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
3 The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients Unknown status NCT03067194 Phase 4 Celecoxib 100 MG;Celecoxib 200mg
4 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
5 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
6 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
7 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
8 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
9 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
10 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
11 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
12 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
13 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
14 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
15 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
16 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
17 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
18 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
19 A Safety Study of Hylan GF-20 to Treat Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
20 Outcomes of Injections in Patients Waiting for Total Knee Replacement Unknown status NCT03090698 Phase 4 Hylan G-F 20;Triamcinolone
21 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
22 Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
23 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
24 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
25 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
26 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle Unknown status NCT02627859 Phase 4
27 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
28 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
29 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
30 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
31 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
32 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
33 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
34 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
35 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
36 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
37 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
38 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
39 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
40 Artelon Metatarsophalangeal (MTP) Spacer Unknown status NCT01028469 Phase 4
41 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
42 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
43 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
44 Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty Unknown status NCT03328832 Phase 4 Topical tranexamic acid;Floseal®;rivaroxaban (10mg)
45 Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin
46 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
47 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
48 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
49 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
50 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem�-derived chondrocytes for treatment of osteochondral defects
AlloStem�, adipose-derived mesenchymal stem cells combined with allograft bone for bone grafting
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel�, autologous cultured chondrocytes for treatment of cartilage defects
CARTISTEM�, mesenchymal stem cells for treatment of osteoarthritis
Chondrocell�, bone marrow-derived mesenchymal stem cells for osteoarthritis
Chondrogen�, mesenchymal stem cells for meniscus regeneration and knee osteoarthritis prevention
HiQCell�, adipose-derived stromal vascular fraction for osteoarthritis
JACC�, cultured cartilage for chondral lesion
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem�, adipose-derived mesenchymal stem cells for degenerative arthritis
StempeucelOA�, mesenchymal stem cells for treatment of osteoarthritis
Trinity� Evolution�, mesenchymal stem cells with osteoprogenitors for musculoskeletal defects
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem� 4D20.8, NCr-fac Progenitor PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem�) PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel�) PMIDs: 17515233 17590152 16510814
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 10102814 14673997 19530993 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC�) PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel�) PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity� Evolution�) PMIDs: 21056860 20508015

Cochrane evidence based reviews: osteoarthritis

Genetic Tests for Osteoarthritis

Genetic tests related to Osteoarthritis:

# Genetic test Affiliating Genes
1 Osteoarthritis 30
2 Degenerative Joint Disease 30

Anatomical Context for Osteoarthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteoarthritis:

20
Joint

MalaCards organs/tissues related to Osteoarthritis:

42
Bone, Bone Marrow, Testes, Skin, Brain, Breast, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
2 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
3 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
4 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
5 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
6 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
7 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
8 Cartilage Temporomandibular Joint Affected by disease
9 Bone Vertebrae Affected by disease

Publications for Osteoarthritis

Articles related to Osteoarthritis:

(show top 50) (show all 6248)
# Title Authors Year
1
Disease burden in osteoarthritis (OA) is similar to rheumatoid arthritis (RA) at initial rheumatology visit and significantly greater 6-months later. ( 30891933 )
2019
2
Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis. ( 30910989 )
2019
3
Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis. ( 30834598 )
2019
4
Patient Satisfaction Following Total Knee Arthroplasty: Comparison of Short-Term Results in Rheumatoid Arthritis and Osteoarthritis. ( 30805417 )
2019
5
Rates and outcomes of total knee replacement for rheumatoid arthritis compared to osteoarthritis. ( 30770628 )
2019
6
Distribution of abnormal IgG glycosylation patterns from rheumatoid arthritis and osteoarthritis patients by MALDI-TOF-MSn. ( 30714583 )
2019
7
Patient-Reported Outcome Measures of Total Knee Arthroplasties for Post-Traumatic Arthritis versus Osteoarthritis: A Short-Term (5- to 10-year) Retrospective Matched Cohort Study. ( 30745082 )
2019
8
Prevalence and distribution of cartilage damage at the metacarpal head level in rheumatoid arthritis and osteoarthritis: an ultrasound study. ( 30690561 )
2019
9
Efficacy of Integrating a Novel 16-Gene Biomarker Panel and Intelligence Classifiers for Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis. ( 30621359 )
2019
10
Validation of the Ankle Osteoarthritis Scale Instrument for Preoperative Evaluation of End-Stage Ankle Arthritis Patients Using Item Response Theory. ( 30628474 )
2019
11
Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis. ( 30483789 )
2019
12
Measurement properties of the OARSI core set of performance-based measures for hip osteoarthritis: a prospective cohort study on reliability, construct validity and responsiveness in 90 hip osteo-arthritis patients. ( 30451049 )
2019
13
The prevalence of depression and insomnia symptoms among patients with rheumatoid arthritis and osteoarthritis in Poland: a case control study. ( 30286609 )
2019
14
Subclinical crystal arthropathy: a silent contributor to inflammation and functional disability in knees with osteoarthritis-an ultrasound study. ( 30327988 )
2019
15
Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis. ( 30855434 )
2019
16
How much gloom is in groans? Depression and its determinants in Nigerian patients with knee osteoarthritis: a multi-center cross-sectional study. ( 30847688 )
2019
17
Worsen depression after viscosupplementation treatment for geriatric people with knee osteoarthritis? ( 30619495 )
2019
18
Type 2 diabetes mellitus and osteoarthritis. ( 30712918 )
2019
19
IL-10 Could Play a Role in the Interrelation between Diabetes Mellitus and Osteoarthritis. ( 30759730 )
2019
20
Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink. ( 30685347 )
2019
21
Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin-Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium Deficiency. ( 30661165 )
2019
22
Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. ( 30719180 )
2019
23
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017. ( 30913167 )
2019
24
Evidence synthesis of types and intensity of therapeutic land-based exercises to reduce pain in individuals with knee osteoarthritis. ( 30915489 )
2019
25
Preliminary study on a novel minimally invasive extra-articular implant for unicompartmental knee osteoarthritis. ( 30852111 )
2019
26
Clinical efficacy of celecoxib for osteoarthritis and bone anchor assisted knee extensor reconstruction. ( 30852482 )
2019
27
Fatty infiltration in the thigh muscles in knee osteoarthritis: a systematic review and meta-analysis. ( 30852623 )
2019
28
Chondrocyte dedifferentiation and osteoarthritis (OA). ( 30853397 )
2019
29
Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction. ( 30854241 )
2019
30
Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model. ( 30854676 )
2019
31
miR-193b-5p regulates chondrocytes metabolism by directly targeting histone deacetylase 7 in interleukin-1β-induced osteoarthritis. ( 30854734 )
2019
32
Evaluation of pharmacokinetics and pharmaco-dynamics of sinomenine-hyaluronic acid conjugate after intra-articular administration for osteoarthritis treatment. ( 30858696 )
2019
33
Unifying the seeds auto-generation (SAGE) with knee cartilage segmentation framework: data from the osteoarthritis initiative. ( 30859457 )
2019
34
Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis. ( 30859538 )
2019
35
Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis. ( 30860559 )
2019
36
Open-Loop Audiovisual Stimulation Induces Delta EEG Activity in Older Adults With Osteoarthritis Pain and Insomnia. ( 30862174 )
2019
37
Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. ( 30862551 )
2019
38
Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis. ( 30862648 )
2019
39
The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis. ( 30865775 )
2019
40
Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model. ( 30868494 )
2019
41
Combined use of Serum miR-338-3p, Cartilage Oligomeric Matrix Protein and Chondroitin Sulfate-846 in the Early Diagnosis of Knee Osteoarthritis. ( 30868862 )
2019
42
Relationship between Sleep Duration and Osteoarthritis in Middle-Aged and Older Women: A Nationwide Population-Based Study. ( 30871193 )
2019
43
Intra-articular Recombinant Human Growth Hormone Injection Compared with Hyaluronic Acid and Placebo for an Osteoarthritis Model of New Zealand Rabbits. ( 30871292 )
2019
44
Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. ( 30871298 )
2019
45
Gait mechanics contribute to exercise induced pain flares in knee osteoarthritis. ( 30871519 )
2019
46
Clinical Outcome of Osteocapsular Arthroplasty for Primary Osteoarthritis of the Elbow: Comparison of Arthroscopic and Open Procedure. ( 30871900 )
2019
47
Joint position sense impairments in older adults with carpometacarpal osteoarthritis: A descriptive comparative study. ( 30871959 )
2019
48
MicroRNA-26a reduces synovial inflammation and cartilage injury in osteoarthritis of knee joints through impairing the NF-κB signaling pathway. ( 30872407 )
2019
49
Evaluation of Intravenously Delivered Allogeneic Mesenchymal Stem Cells for Treatment of Elbow Osteoarthritis in Dogs: A Pilot Study. ( 30873568 )
2019
50
The handedness of Michelangelo. Impact of difficulties with writing in later life, which were attributed to hand osteoarthritis. Comment to Davide Lazzeri article "The Handedness of Michelangelo Buonarroti". ( 30874330 )
2019