Aliases & Classifications for Osteoarthritis

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 38 12 76 25 29 55 6 43 3 15 63 40
Degenerative Joint Disease 12 25 29
Degenerative Polyarthritis 25 73
Hypertrophic Arthritis 12 25
Osteoarthrosis 12 25
Arthropathy 25 73
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 25
Osteoarthrosis Deformans 73
Arthritis, Degenerative 25
Degenerative Arthritis 12
Kashin-Beck Disease 73
Oa 25

Characteristics:


Classifications:



External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 35 715.3
SNOMED-CT via HPO 69 263681008 258211005 239872002

Summaries for Osteoarthritis

MedlinePlus : 43 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint No single test can diagnose osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteoarthritis, also known as degenerative joint disease, is related to cartilage disease and pseudoachondroplasia, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is FRZB (Frizzled Related Protein), and among its related pathways/superpathways are Degradation of the extracellular matrix and Endochondral Ossification. The drugs Spironolactone and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are abnormality of pelvic girdle bone morphology and hip osteoarthritis

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. It is sometimes called degenerative joint disease or “wear and tear” arthritis. It most frequently occurs in the hands, hips, and knees. With OA, the cartilage and bones within a joint begin to break down. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling, and can result in disability.

Genetics Home Reference : 25 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

PubMed Health : 63 About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age.If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 76 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Related Diseases for Osteoarthritis

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 cartilage disease 33.1 ACAN COL2A1 COMP
2 pseudoachondroplasia 32.7 ACAN COMP MATN3
3 degenerative disc disease 31.2 ACAN ASPN GDF5
4 osteochondritis dissecans 31.1 ACAN COMP MATN3 MMP13
5 multiple epiphyseal dysplasia 30.9 ACAN COL2A1 COMP MATN3
6 spondyloepiphyseal dysplasia congenita 30.8 ASPN COL2A1 COMP MMP13
7 brachydactyly 30.4 COL2A1 COMP GDF5
8 myeloma, multiple 28.7 GAS5 H19 HOTAIR MEG3
9 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 12.5
10 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.4
11 osteoarthritis with mild chondrodysplasia 12.3
12 short stature-advanced bone age-early-onset osteoarthritis syndrome 11.9
13 loeys-dietz syndrome 3 11.8
14 familial osteochondritis dissecans 11.8
15 czech dysplasia 11.5
16 arthritis 11.3
17 rheumatoid arthritis 11.3
18 otospondylomegaepiphyseal dysplasia, autosomal recessive 11.3
19 developmental dysplasia of the hip 1 11.3
20 spondylosis 11.2
21 chondrocalcinosis 1 11.1
22 beukes hip dysplasia 11.1
23 alkaptonuria 11.1
24 spondyloepiphyseal dysplasia tarda, x-linked 11.1
25 ehlers-danlos syndrome 11.1
26 ochronosis 11.1
27 occipital neuralgia 11.1
28 achondrogenesis, type ia 11.0 ACAN COL2A1
29 achondrogenesis, type ii 11.0 ACAN COL2A1 COMP
30 kniest dysplasia 11.0 ASPN COL2A1 COMP
31 brachyolmia type 3 11.0
32 spondyloepiphyseal dysplasia, stanescu type 11.0
33 skeletal dysplasias 10.9 COL2A1 COMP MATN3
34 epiphyseal dysplasia, multiple, 1 10.9
35 hypochondrogenesis 10.9 ACAN ASPN COL2A1 COMP
36 bone deterioration disease 10.9 ACAN COL2A1 GDF5 MMP13
37 coxa vara 10.9 COL2A1 MMP13
38 bone structure disease 10.9 ACAN COL2A1 GDF5 MMP13
39 legg-calve-perthes disease 10.9
40 bone development disease 10.9 COL2A1 COMP GDF5 MATN3
41 otospondylomegaepiphyseal dysplasia, autosomal dominant 10.9
42 diastrophic dysplasia 10.9
43 spondyloepimetaphyseal dysplasia with joint laxity, type 2 10.9
44 digital arthropathy-brachydactyly, familial 10.9
45 bone inflammation disease 10.9 ACAN COL2A1 COMP MMP13
46 mucopolysaccharidosis type vi 10.8
47 bone disease 10.8 ACAN COL2A1 GDF5 MMP13
48 pilomyxoid astrocytoma 10.8 COL2A1 H19
49 angel-shaped phalangoepiphyseal dysplasia 10.7
50 stickler syndrome, type i 10.7

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Dysthymic Disorder Esophagitis
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

Human phenotypes related to Osteoarthritis:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of pelvic girdle bone morphology 32 HP:0002644
2 hip osteoarthritis 32 HP:0008843

UMLS symptoms related to Osteoarthritis:


arthralgia, back pain, metatarsalgia, muscle cramp, sciatica, other symptoms referable to joint, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, joint stiffness, musculoskeletal symptom, other symptoms referable to joint, site unspecified, joint symptom, stiffness of joint, not elsewhere classified in icd10cm, angina pectoris, tremor, equilibration disorder

MGI Mouse Phenotypes related to Osteoarthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.17 ASPN COL2A1 COMP FRZB GDF5 MATN3

Drugs & Therapeutics for Osteoarthritis

PubMedHealth treatment related to Osteoarthritis: 63

There are many different suggestions and recommendations for treating osteoarthritis, but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible.There are two different types of therapies: Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy.The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle-strengthening exercises could help people with knee osteoarthritis. Other treatment options include massage, acupuncture, TENS, medicinal baths or orthopedic insoles.Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation. There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 655)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-84-3 187
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
4
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
5
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
6
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
7
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
8
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 4594 9579578
9
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 1302 156391
10
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
11
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
12
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
13
Iron Approved Phase 4,Phase 1,Phase 2,Not Applicable 7439-89-6 23925
14
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
16
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 71273 175805
17
Hyoscyamine Approved Phase 4 101-31-5 64692
18
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
19
Rivaroxaban Approved Phase 4,Phase 3,Not Applicable 366789-02-8
20
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
21
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
22
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 74103-06-3, 66635-83-4 3826
23
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
24
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
25
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
27
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 27203-92-5 33741
28
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
29
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 15307-86-5 3033
30
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
31
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
32
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Not Applicable 148553-50-8 5486971
33
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
34
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 71125-38-7 5281106 54677470
35
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
36
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
37 Parecoxib Approved Phase 4,Phase 3,Not Applicable 198470-84-7
38
Aminocaproic Acid Approved, Investigational Phase 4,Phase 2,Not Applicable 60-32-2 564
39
Chromium Approved Phase 4,Phase 3,Phase 2,Not Applicable 7440-47-3 27668
40
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
41
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 113775-47-6 68602 5311068
42
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
43
Ketamine Approved, Vet_approved Phase 4,Not Applicable 6740-88-1 3821
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 437-38-7 3345
45
Armodafinil Approved, Investigational Phase 4 112111-43-0
46
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
47
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
48
Codeine Approved, Illicit Phase 4,Phase 3,Phase 2 76-57-3 5284371
49
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 93-14-1 3516
50
Infliximab Approved Phase 4 170277-31-3

Interventional clinical trials:

(show top 50) (show all 3655)
# Name Status NCT ID Phase Drugs
1 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
2 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
3 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
4 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
5 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
6 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
7 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
8 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
9 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
10 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
11 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
12 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
13 Daily Activity and Gait Analysis After Viscosupplement Injection Among Hip Osteoarthritis Patients Unknown status NCT02086474 Phase 4 Hyaluronan;Bupivacaine
14 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
15 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
16 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
17 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
18 A Safety Study of Hylan GF-20 to Treat Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
19 Safety and Efficacy of Intra-articular Ozone Injections for Knee Osteoarthritis Unknown status NCT02833545 Phase 4
20 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
21 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
22 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
23 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
24 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
25 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
26 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
27 Does Intraoperative Intravenous Iron Enhance Postoperative Oxygenation Profile in Total Knee Arthroplasty Surgery? Unknown status NCT02544464 Phase 4 ferric carboxymaltose 1000 mg;placebo
28 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
29 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
30 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
31 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
32 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
33 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
34 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
35 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
36 Artelon Metatarsophalangeal (MTP) Spacer Unknown status NCT01028469 Phase 4
37 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
38 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
39 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
40 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
41 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
42 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
43 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
44 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
45 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine
46 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
47 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
48 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4 Quetiapine XR
49 Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty Unknown status NCT02808728 Phase 4 Pain Cocktail with Exparel;Pain Cocktail with Ropivacaine
50 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
AlloStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel PMIDs: 17515233 17590152 16510814
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 10102814 14673997 19530993 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity PMIDs: 21056860 20508015

Genetic Tests for Osteoarthritis

Genetic tests related to Osteoarthritis:

# Genetic test Affiliating Genes
1 Osteoarthritis 29 FRZB
2 Degenerative Joint Disease 29

Anatomical Context for Osteoarthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteoarthritis:

19
Joint

MalaCards organs/tissues related to Osteoarthritis:

41
Bone, Bone Marrow, Testes, Skin, Brain, Liver, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
2 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
3 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
4 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
5 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
6 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
7 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
8 Cartilage Temporomandibular Joint Affected by disease
9 Bone Vertebrae Affected by disease

Publications for Osteoarthritis

Articles related to Osteoarthritis:

(show top 50) (show all 2630)
# Title Authors Year
1
Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks. ( 29080354 )
2018
2
Extracorporeal shockwave therapy for the treatment of knee osteoarthritis: A retrospective study. ( 29979441 )
2018
3
Recent advances in hyaluronic acid based therapy for osteoarthritis. ( 29450666 )
2018
4
Functionality in Middle-Aged and Older Overweight and Obese Individuals with Knee Osteoarthritis. ( 29973574 )
2018
5
An Update on Unloading Knee Braces in the Treatment of Unicompartmental Knee Osteoarthritis from the Last 10 Years: A Literature Review. ( 29978048 )
2018
6
Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? ( 29980827 )
2018
7
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
8
Short-Term Outcomes in Treatment of Knee Osteoarthritis With 4 Bone Marrow Concentrate Injections. ( 29977117 )
2018
9
The role of skeletal muscle in the pathophysiology and management of knee osteoarthritis. ( 29444285 )
2018
10
The knitting community-based trial for older women with osteoarthritis of the hands: design and rationale of a randomized controlled trial. ( 29444664 )
2018
11
Are Carpal Tunnel Syndrome and Regional Degenerative Osteoarthritis Linked? Results of a Case-Control Study. ( 29409410 )
2018
12
Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: a systematic review. ( 29446485 )
2018
13
Cationic poly-l-lysine-encapsulated melanin nanoparticles as efficient photoacoustic agents targeting to glycosaminoglycans for the early diagnosis of articular cartilage degeneration in osteoarthritis. ( 29972184 )
2018
14
A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis. ( 29922449 )
2018
15
The presence of cardiovascular disease does not modify the weak impact obesity has on health-related quality of life in patients with hip osteoarthritis in the KHOALA cohort. ( 28242173 )
2018
16
Early morphologic changes in trapeziometacarpal joint bones with osteoarthritis. ( 29981379 )
2018
17
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study. ( 28365812 )
2018
18
Usefulness of dual-energy computed tomography for the evaluation of psoriatic arthritis accompanied by knee osteoarthritis. ( 29974970 )
2018
19
Osteoarthritis-Like Changes in Bardet-Biedl Syndrome Mutant Ciliopathy Mice (<i>Bbs1</i><sup>M<i>390</i>R/M<i>390</i>R</sup>): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation. ( 29971011 )
2018
20
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. ( 29968759 )
2018
21
Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. ( 29445972 )
2018
22
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis. ( 29356574 )
2018
23
Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging. ( 29451138 )
2018
24
Osteoarthritis-related walking disability and arterial stiffness-results from a cross-sectional study. ( 29975013 )
2018
25
Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling. ( 29978613 )
2018
26
Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis. ( 29561445 )
2018
27
Development and persistence of suspected neuropathic pain after total knee arthroplasty in individuals with osteoarthritis. ( 29452296 )
2018
28
Oromandibular Dystonia-Related Temporomandibular Joint Osteoarthritis: A Case History Report. ( 29723311 )
2018
29
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. ( 29444976 )
2018
30
Is the association between obesity and hip osteoarthritis surgery explained by familial confounding? ( 29381493 )
2018
31
Atrophy of hip abductor muscles is related to clinical severity in a hip osteoarthritis population. ( 29446121 )
2018
32
Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. ( 29971707 )
2018
33
Adipokine genes and radiographic hand osteoarthritis in Finnish women: a cross-sectional study. ( 28812414 )
2018
34
Isolated aortic dilation without osteoarthritis: a case of SMAD3 mutation. ( 29444731 )
2018
35
Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative. ( 29449014 )
2018
36
In thumb base osteoarthritis structural damage is more strongly associated with pain than synovitis. ( 29709499 )
2018
37
Allogeneic adipose-derived mesenchymal stem cells (Horse Allo 20) for the treatment of osteoarthritis associated lameness in horses: characterization, safety and efficacy of intraarticular treatment. ( 29978736 )
2018
38
Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis. ( 29514696 )
2018
39
Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. ( 29980200 )
2018
40
Risk and risk factors for revision after primary reverse shoulder arthroplasty for cuff tear arthropathy and osteoarthritis: a Nordic Arthroplasty Register Association study. ( 29779980 )
2018
41
Treating Severe Knee Osteoarthritis with Combination of Intra-Osseous and Intra-Articular Infiltrations of Platelet-Rich Plasma: An Observational Study. ( 29448817 )
2018
42
Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. ( 29320581 )
2018
43
Pain-Associated Transcriptome Changes in Synovium of Knee Osteoarthritis Patients. ( 29973527 )
2018
44
Pharmaceutical-grade chondroitin sulfate in the management of knee osteoarthritis. ( 29451036 )
2018
45
Degenerative Osteoarthritis with Multiple Joint Arthroplasties Due to Alkaptonuria, a Rare Inborn Error of Tyrosine Metabolism. ( 29629736 )
2018
46
The role of fat and inflammation in the pathogenesis and management of osteoarthritis. ( 29444323 )
2018
47
Safety and Predictive Factors of Short-Term Efficacy of a Single Injection of Mannitol-Modified Cross-Linked Hyaluronic Acid in Patients with Trapeziometacarpal Osteoarthritis. Results of a Multicentre Prospective Open-Label Pilot Study (INSTINCT Trial). ( 29977118 )
2018
48
Psychometric properties of the EQ-5D-5L in patients with hip or knee osteoarthritis: reliability, validity and responsiveness. ( 29978346 )
2018
49
CORR InsightsAr: Validation of the Chinese (Mandarin) Version of the Oxford Knee Score in Patients with Knee Osteoarthritis. ( 29443846 )
2018
50
Modified SauvAc-Kapandji procedure for the distal radioulnar joint disorders of osteoarthritis and rheumatoid arthritis. ( 29551357 )
2018