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OA
MCID: OST012
MIFTS: 77

Osteoarthritis (OA)

Categories: Bone diseases, Muscle diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Osteoarthritis

About this section

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 12 74 43 29 54 6 42 3 15 37 62 39 17
Osteoarthrosis 12 43 15
Degenerative Joint Disease 12 43
Degenerative Polyarthritis 43 71
Hypertrophic Arthritis 12 43
Arthropathy 43 71
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 43
Osteoarthrosis Deformans 71
Arthritis, Degenerative 43
Degenerative Arthritis 12
Kashin-Beck Disease 71
Oa 43

Classifications:

MalaCards categories:
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 34 715.3
UMLS 71 C0022408 C0029408 C0086743 more
Sources

Summaries for Osteoarthritis

About this section
MedlinePlus Genetics : 43 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.Osteoarthritis usually develops slowly, causing pain, stiffness, and restricted movement as the condition gets worse. Areas of bone no longer cushioned by cartilage rub against each other and start to break down. Further damage is caused as the body attempts to repair and rebuild these tissues. The immune system, which plays a role in healing injuries, targets these areas, and its response leads to inflammation of the joint tissues. Abnormal growths of bone (osteophytes) and other tissue can also occur, and may be visible as enlarged joints. Enlargement of the joints of the fingers is especially noticeable.People with osteoarthritis typically experience stiffness following periods of inactivity such as upon awakening or rising from a chair; the stiffness usually improves as they move around. In some affected individuals, the condition never causes major problems. In others, severe osteoarthritis can impair mobility and the ability to perform daily tasks, affecting quality of life and increasing the risk of other health conditions such as cardiovascular disease.Osteoarthritis is most common in middle age or late adulthood, because the cartilage at the joints naturally begins to thin as people age. However, it can occur earlier in life, especially after injuries affecting the joints such as a type of knee injury called an anterior cruciate ligament (ACL) tear. People who are overweight or whose activities are particularly stressful to the joints are also at increased risk of developing osteoarthritis.

MalaCards based summary : Osteoarthritis, also known as osteoarthrosis, is related to epiphyseal dysplasia, multiple, 2 and pseudoachondroplasia, and has symptoms including tremor, joint stiffness and back pain. An important gene associated with Osteoarthritis is FRZB (Frizzled Related Protein), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Chlorzoxazone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone.

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

MedlinePlus : 42 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint There is no specific test for osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or "wear and tear" arthritis. It occurs most frequently in the hands, hips, and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

PubMed Health : 62 About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age. If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 74 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Sources

Related Diseases for Osteoarthritis

About this section

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1144)
# Related Disease Score Top Affiliating Genes
1 epiphyseal dysplasia, multiple, 2 32.5 MATN3 COMP
2 pseudoachondroplasia 32.3 MATN3 COMP COL2A1 ACAN
3 exostosis 32.3 GDF5 COL2A1 ACAN
4 synovitis 32.2 COMP COL2A1 ACAN
5 diastrophic dysplasia 32.2 MATN3 COMP COL2A1
6 cartilage disease 32.1 GDF5 COMP COL2A1 ACAN
7 epiphyseal dysplasia, multiple, 1 32.0 MATN3 COMP
8 arthropathy 31.9 COMP COL2A1 CILP ACAN
9 epiphyseal dysplasia, multiple, 5 31.9 MATN3 COMP
10 rheumatoid arthritis 31.9 HOTAIR H19 COMP COL2A1 CILP ACAN
11 osteochondrosis 31.3 MATN3 COMP COL2A1 ACAN
12 chondromalacia 31.2 COMP ACAN
13 bone disease 31.2 MATN3 GDF5 COMP COL2A1 ACAN
14 osteochondritis dissecans 31.1 MATN3 COMP ACAN
15 degenerative disc disease 31.1 GDF5 ASPN ACAN
16 spondyloepiphyseal dysplasia with congenital joint dislocations 31.1 COMP COL2A1 ACAN
17 spondylolisthesis 31.0 GDF5 ACAN
18 multiple epiphyseal dysplasia 30.9 MATN3 COMP COL2A1 ACAN
19 spondylolysis 30.8 GDF5 ACAN
20 multiple epiphyseal dysplasia, autosomal dominant 30.8 MATN3 COMP
21 bone inflammation disease 30.8 COMP COL2A1 ACAN
22 spondyloepiphyseal dysplasia congenita 30.7 MATN3 COMP COL2A1
23 stickler syndrome 30.7 MATN3 COL2A1 ACAN
24 achondroplasia 30.6 COMP COL2A1 ACAN
25 brachydactyly 30.6 GDF5 COMP COL2A1 ACAN
26 patella, chondromalacia of 30.5 COMP COL2A1 ACAN
27 skeletal dysplasias 30.5 MATN3 COMP COL2A1
28 brittle bone disorder 30.2 COMP COL2A1 ACAN
29 hypochondrogenesis 30.1 MATN3 COL2A1 ASPN ACAN
30 spondyloepimetaphyseal dysplasia 30.1 MATN3 COL2A1 ACAN
31 odontochondrodysplasia 30.0 MATN3 GDF5 COMP COL2A1 ACAN
32 clubfoot 29.8 HOTAIR GDF5 COL2A1
33 pituitary adenoma 29.7 MEG3 HOTAIR H19
34 thyroid carcinoma 29.5 HOTAIR H19 GAS5
35 osteogenic sarcoma 29.3 PACERR MEG3 HOTAIR H19 GAS5 FRZB
36 lung cancer susceptibility 3 29.1 MEG3 HOTAIR H19 GAS5
37 myeloma, multiple 29.1 MEG3 HOTAIR H19 GAS5
38 high grade glioma 28.9 PCGEM1 MEG3 HOTAIR H19 GAS5
39 multicentric osteolysis, nodulosis, and arthropathy 11.7
40 progressive pseudorheumatoid dysplasia 11.6
41 loeys-dietz syndrome 3 11.6
42 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.6
43 osteoarthritis with mild chondrodysplasia 11.5
44 czech dysplasia 11.5
45 behcet's syndrome arthropathy 11.4
46 chondrocalcinosis 2 11.4
47 myhre syndrome 11.4
48 familial osteochondritis dissecans 11.4
49 transient arthropathy 11.3
50 beukes hip dysplasia 11.3

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Decubitus Ulcer
Deficiency Anemia Dysthymic Disorder
Esophagitis First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Iron Deficiency Anemia Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis
Sources

Symptoms & Phenotypes for Osteoarthritis

About this section

UMLS symptoms related to Osteoarthritis:


tremor, joint stiffness, back pain, angina pectoris, arthralgia, sciatica, equilibration disorder, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified
Sources

Drugs & Therapeutics for Osteoarthritis

About this section

PubMed Health treatment related to Osteoarthritis: 62

There are many different suggestions and recommendations for treating osteoarthritis , but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible. There are two different types of therapies : Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy . The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle -strengthening exercises could help people with knee osteoarthritis . Other treatment options include massage , acupuncture , TENS, medicinal baths or orthopedic insoles. Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy ). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation . There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 514)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorzoxazone Approved Phase 4 95-25-0 2733
2
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
3
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
4
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
5
Ibuprofen Approved Phase 4 15687-27-1 3672
6
Thrombin Approved, Investigational Phase 4
7
Capsaicin Approved Phase 4 404-86-4 1548943
8
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
9 Orange Approved Phase 4
10
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
11
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
12
Zoledronic Acid Approved Phase 4 118072-93-8 68740
13
Rivaroxaban Approved Phase 4 366789-02-8
14
Dalteparin Approved Phase 4 9005-49-6
15
Enoxaparin Approved Phase 4 9005-49-6 772
16
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
17
Remifentanil Approved Phase 4 132875-61-7 60815
18
Prilocaine Approved Phase 4 721-50-6 4906
19
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
20
Liraglutide Approved Phase 4 204656-20-2 44147092
21
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
22
Demeclocycline Approved Phase 4 127-33-3 5311063
23
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
24
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
25
Infliximab Approved Phase 4 170277-31-3
26
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
27
Indian frankincense Approved, Experimental, Investigational Phase 4
28
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
29
Nabumetone Approved Phase 4 42924-53-8 4409
30
Aceclofenac Approved, Investigational Phase 4 89796-99-6 71771
31
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
32
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
33
Methylene blue Approved, Investigational Phase 4 61-73-4
34
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
35
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
36
Promethazine Approved, Investigational Phase 4 60-87-7 4927
37
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
38
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
39
Zolpidem Approved Phase 4 82626-48-0 5732
40
parecoxib Approved Phase 4 198470-84-7
41
Hyoscyamine Approved Phase 4 101-31-5 64692
42
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
43
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
44
Povidone-iodine Approved Phase 4 25655-41-8
45
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
46
Vancomycin Approved Phase 4 1404-90-6 441141 14969
47
Cefazolin Approved Phase 4 25953-19-9 656510 33255
48
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
49
Colchicine Approved Phase 4 64-86-8 6167 2833
50
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3

Interventional clinical trials:

(show top 50) (show all 4067)
# Name Status NCT ID Phase Drugs
1 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
2 The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy Unknown status NCT02640144 Phase 4 Sodium Hyaluronate 1%;Placebo
3 Investigating the Use of a Cryopneumatic Therapy Device in Primary Total Knee Arthroplasty Patients Unknown status NCT00712816 Phase 4
4 Corticosteroids as Additive in Arthrocentesis of the Temporomandibular Joint: Double Blind, Randomised Controlled Trial of Effectiveness. Unknown status NCT01275014 Phase 4 Dexamethasone;Isotonic saline
5 A Double-Blind, Placebo-Controlled, Crossover Pilot Study of the Efficacy of Celecoxib 200 Mg Qd in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee Unknown status NCT00194090 Phase 4 celecoxib
6 Viscosupplementation in Patients With Severe Osteoarthritis of the Knee Unknown status NCT03090698 Phase 4 Hylan G-F 20;Triamcinolone
7 Randomized Double-blind Study on the Treatment of Osteoarthritis of the Bilateral Knee: Autologous Bone Marrow Concentrate vs. Hyaluronic Acid Unknown status NCT03110679 Phase 4
8 Comparison of Therapeutic Effects of Hyaluronic Acid vs. Hyaluronic Acid Combined Corticosteroid on Knee Osteoarthritis: A Double Blind, Randomized-controlled Clinical Trial Unknown status NCT02625727 Phase 4
9 Additional Therapeutic Effects of Dextrose to Hyaluronic Acid on Knee Osteoarthritis: a Double Blind, Randomized-controlled Clinical Trial Unknown status NCT03238183 Phase 4 dextrose
10 Additional Therapeutic Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis: A Double Blind, Randomized-controlled Clinical Trial Unknown status NCT02949466 Phase 4 Triamcinolone
11 Effect of Preoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty : A Randomized, Controlled, Double-Blind Trial Unknown status NCT03561506 Phase 4 Ferric carboxymaltose;0.9% Normal Saline
12 Effect of Preoperative Intravenous Dexamethasone on Postoperative Pain After Primary Total Hip Arthroplasty : A Prospective, Double-blind, Randomized Controlled Trial Unknown status NCT03542617 Phase 4 Dexamethasone;Normal Saline Solution
13 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty - Randomized Prospective Study Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
14 Effect of Postoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty : A Randomized, Controlled, Double-Blind Trial Unknown status NCT03561480 Phase 4 Ferric carboxymaltose;0.9% Normal Saline
15 Intra-Articular Injections of Hyaluronan Versus 20 Ml NaCl Versus Placebo in Treatment of Knee Osteoarthritis: a Randomised, Double-Blind, Placebo Controlled Single Centre Trial. Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
16 The Effects of Tourniquet Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
17 Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty: A Randomized Controlled Study Unknown status NCT03792828 Phase 4 Duloxetine HCl 30mg
18 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
19 Randomized, Double-blind, Placebo-controlled Study to Asses the Effect of Chondroitin Sulphate in Patients With Knee Osteoarthritis by Functional Magnetic Resonance Imaging Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
20 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex and AGC Unknown status NCT00294528 Phase 4
21 A Double-blind, Randomized, Controlled, Equivalence Study Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
22 Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis: A Randomized Double-blind, Saline-controlled Trial Unknown status NCT03484091 Phase 4 Hyruan-One;Hylan G-F 20;Normal saline
23 Outcome Comparison of Allogenic Cancellous Bone and a New Synthetic Bone Substitute (geneX®) in Filling the Bone Defect Created With Medial Open Wedge High Tibial Osteotomy Unknown status NCT02000297 Phase 4
24 A Multicenter，Open-label Phase Ⅳ Trial of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
25 The Biomechanical Impact of Intra-Articular Hyaluronic Acid in Knee Osteoarthritis Patients: A Randomized, Double Blind, Placebo Controlled Study Unknown status NCT00778076 Phase 4
26 Intra-articular Botulinum Toxin Type A Versus Corticosteroids: a Clinical Trial in Osteoarthritis of Knees Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
27 Influence of Perception of Patients Suffering of Osteoarthritis of Knee Over the Effectiveness and Tolerance in Intra-articular Injection of Corticoids: a Prospective, Controlled and Randomized Study Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
28 A Multi-center, Randomized, Open-label, Parallel-arm Controlled Study Comparing Demand-based Monotherapy of Non-steroidal Anti-inflammatory Drug (NSAID) vs. Demand-based NSAID Combined With Sodium Hyaluronate Injection in the Treatment of Chinese Patients With Mild to Moderate Knee Osteoarthritis Unknown status NCT02826031 Phase 4 Sodium Hyaluronate Injection;DICL-SR
29 A Prospective, Randomized, Double-blinded, Multi-center, Trial to Evaluate Efficacy and Safety of Combination of Diacerein and Celecoxib Administered Orally in Patients With Knee Osteoarthritis Unknown status NCT03404479 Phase 4 Diacerein;Celecoxib
30 A Multicentre, Randomized, Double-blinded, Parallel-controlled, Non-inferiority Clinical Study Of Safety and Efficacy Of Medical Chitosan for Knee Osteoarthritis Compared With Sodium Hyaluronate Injection Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
31 A Randomized, Double Blind, Single Simulation, Parallel Controlled, Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
32 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
33 The Effect of Glucosamine Sulphate on Structural Disease Progression in Knee Osteoarthritis and the Cost-effectiveness of Glucosamine Sulphate for Knee Arthritis. Unknown status NCT00513422 Phase 4
34 Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients: A Randomized Controlled Study Unknown status NCT03109652 Phase 4 Tranexamic Acid
35 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
36 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
37 Prospective, Single Arm, Pilot Study Evaluating the Safety and Efficacy of Hyaluronan (Hylan GF-20) in Patients With Painful Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
38 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
39 Effect of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function in Healthy Subjects and Patients With Osteoarthritis Unknown status NCT03781544 Phase 4 Tramadol;Paracetamol;Diclofenac
40 A Prospective, Randomized, Double-blinded, Double-dummy, Active-controlled, Multi-center, Interventional Study to Compare Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
41 Double-blind, Randomised, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of the Combination of Chondroitin Sulphate and Glucosamine Hydrochloride in Patients With Hand Osteoarthritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
42 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
43 Artelon MTP Spacer - Surgical Treatment of Mild to Moderate Hallux Rigidus Unknown status NCT01028469 Phase 4
44 Effectiveness of Intraoperative Exparel, a Bupivacaine Liposome Injectable Suspension, for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study Unknown status NCT02808728 Phase 4 Pain Cocktail with Exparel;Pain Cocktail with Ropivacaine
45 Phase IV Study - Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
46 A 26 Week Multicenter Prospective Open Label Clinical Study Evaluating a Single Intra-articular Injection of DUROLANE SJ1ml for Treatment of OA Pain of the Ankle Unknown status NCT02627859 Phase 4
47 A Post-marketing Surveillance to Evaluate the Efficacy and Safety of CHONDRON (Autologous Cultured Chondrocyte) Through Arthroscopy in Patients With Knee Cartilage Defects Unknown status NCT02539069 Phase 4
48 This Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) in Patients With Cartilage Defects in Their Knees. Unknown status NCT02539056 Phase 4
49 Comparison of the Analgesic Efficacy of Continuous Femoral Nerve Block and Adductor Canal Block With Steroid Adjuvant in Patients Undergoing Total Knee Arthroplasty Unknown status NCT01973530 Phase 4
50 Comparison of Topical Tranexamic Acid and Floseal® on Blood Loss After Total Knee Arthroplasty in Patients With a Thromboembolic Risk Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


ACETYLSALICYLATE SODIUM
Aspirin
ASPIRIN PWDR
celecoxib
choline salicylate
Chondroitin
CHONDROITIN SODIUM
Chondroitin Sulfates
Diclofenac
Diclofenac Potassium
Diclofenac Sodium
Diflunisal
Etodolac
Fenoprofen
Fenoprofen Calcium
Flurbiprofen
Flurbiprofen sodium
Glucosamine
HYLAN G-F 20
Ibuprofen
Indomethacin
INDOMETHACIN PWDR
INDOMETHACIN SODIUM
Ketoprofen
KETOPROFEN PWDR
meloxicam
nabumetone
Naproxen
Naproxen sodium
oxaprozin
Piroxicam
rofecoxib
solufenum
Sulindac
Tolmetin
Tolmetin Sodium
valdecoxib

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem-derived chondrocytes for treatment of osteochondral defects
AlloStem, adipose-derived mesenchymal stem cells combined with allograft bone for bone grafting
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel, autologous cultured chondrocytes for treatment of cartilage defects
CARTISTEM, mesenchymal stem cells for treatment of osteoarthritis
Chondrocell, bone marrow-derived mesenchymal stem cells for osteoarthritis
Chondrogen, mesenchymal stem cells for meniscus regeneration and knee osteoarthritis prevention
HiQCell, adipose-derived stromal vascular fraction for osteoarthritis
JACC, cultured cartilage for chondral lesion
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem, adipose-derived mesenchymal stem cells for degenerative arthritis
StempeucelOA, mesenchymal stem cells for treatment of osteoarthritis
Trinity Evolution, mesenchymal stem cells with osteoprogenitors for musculoskeletal defects
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem 4D20.8, NCr-fac Progenitor PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem) PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel) PMIDs: 17515233 16510814 17590152
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 12708651 19530993 14673997 10102814
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC) PMIDs: 19393556 10738867 16226641 12043781 16233853 10679677 19802670 16233778 11284883
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel) PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity Evolution) PMIDs: 20508015 21056860
Sources

Genetic Tests for Osteoarthritis

About this section

Genetic tests related to Osteoarthritis:

# Genetic test Affiliating Genes
1 Osteoarthritis 29 FRZB
Sources

Anatomical Context for Osteoarthritis

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The Foundational Model of Anatomy Ontology organs/tissues related to Osteoarthritis:

19
Joint

MalaCards organs/tissues related to Osteoarthritis:

40
Bone, Bone Marrow, Endothelial, Skeletal Muscle, T Cells, Liver, Cortex
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Temporomandibular Joint Affected by disease
2 Bone Vertebrae Affected by disease
3 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
4 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
5 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
6 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
7 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
8 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
9 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Osteoarthritis

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Articles related to Osteoarthritis:

(show top 50) (show all 33825)
# Title Authors PMID Year
1
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 6 61
15210948 2004
2
Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis. 42 61
33472813 2021
3
A randomized study protocol comparing the platelet-rich plasma with hyaluronic acid in the treatment of symptomatic knee osteoarthritis. 61 42
33466131 2021
4
The global state of research in pain management of osteoarthritis (2000-2019): A 20-year visualized analysis. 61 42
33466135 2021
5
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. 61 54
20495570 2010
6
A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. 61 54
19756630 2010
7
Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. 54 61
20206313 2010
8
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. 54 61
19902332 2010
9
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. 54 61
20131257 2010
10
A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. 61 54
20175976 2010
11
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro. 54 61
19890996 2010
12
[Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis]. 61 54
20423837 2010
13
High specificity but low sensitivity of the cartilage oligomeric matrix protein (COMP) test in rheumatoid arthritis and osteoarthritis. 61 54
20148721 2010
14
Changes in content and synthesis of collagen types and proteoglycans in osteoarthritis of the knee joint and comparison of quantitative analysis with Photoshop-based image analysis. 54 61
19838720 2010
15
Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. 61 54
20131253 2010
16
A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils. 61 54
20077500 2010
17
The genetic epidemiology of osteoarthritis. 54 61
20090528 2010
18
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis. 61 54
20112374 2010
19
The transcript level of interleukin-6 in the cartilage of idiopathic osteoarthritis of knee. 54 61
20393674 2010
20
[Detection of bone erosions in knee osteoarthrosis by serum biomarkers]. 54 61
20422912 2010
21
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. 61 54
19679221 2010
22
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. 61 54
19054821 2009
23
Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. 61 54
20021689 2009
24
Modulating hedgehog signaling can attenuate the severity of osteoarthritis. 54 61
19915594 2009
25
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis. 54 61
19762475 2009
26
Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation. 54 61
19877068 2009
27
Asporin and transforming growth factor-beta gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis. 61 54
19997821 2009
28
Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study. 54 61
19029166 2009
29
COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women. 54 61
19019890 2009
30
Elevated circulating and synovial fluid endoglin are associated with primary knee osteoarthritis severity. 54 61
20082874 2009
31
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. 61 54
19274754 2009
32
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. 61 54
19684582 2009
33
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. 61 54
19268722 2009
34
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. 61 54
19606871 2009
35
Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. 61 54
19682376 2009
36
Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. 61 54
19565481 2009
37
Fibroblast growth factor 2: A new key player in osteoarthritis. 61 54
19565484 2009
38
Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis. 61 54
19602530 2009
39
[Effect of electroacupuncture on the level of IL-1beta and TNF-alpha in patients with osteoarthritis]. 61 54
19835118 2009
40
Pretreatment insulin-like growth factor-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease. 61 54
19366851 2009
41
Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis. 54 61
19217805 2009
42
The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene. 61 54
19486942 2009
43
Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. 61 54
19565498 2009
44
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models. 54 61
19565489 2009
45
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. 61 54
19479880 2009
46
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. 54 61
19494318 2009
47
Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. 54 61
19091605 2009
48
The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment. 54 61
18926729 2009
49
A large kindred of early-onset osteoarthritis of the knee and hip: excluding the link to COL2A1 gene. 54 61
19223283 2009
50
[Determination of the concentrations of interleukin-18 and other cytokines in the synovial fluid in patients with osteoarthritis]. 54 61
19403407 2009