Osteoarthritis (OA)

Categories: Bone diseases, Muscle diseases
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Aliases & Classifications for Osteoarthritis

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 11 42 75 28 53 5 41 2 43 14 36 63 38 33
Osteoarthrosis 11 42 14
Degenerative Joint Disease 11 42
Degenerative Polyarthritis 42 71
Hypertrophic Arthritis 11 42
Arthropathy 42 71
Osteoarthrosis and Allied Disorder 11
Osteoarthritis Deformans 42
Osteoarthrosis Deformans 71
Arthritis, Degenerative 42
Degenerative Arthritis 11
Kashin-Beck Disease 71
Oa 42


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Disease Ontology 11 DOID:8398
ICD9CM 34 715.3
MeSH 43 D010003
UMLS 71 C0022408 C0029408 C0086743 more

Summaries for Osteoarthritis

MedlinePlus: 41 What is osteoarthritis? Osteoarthritis, sometimes called OA, is a type of arthritis that only affects the joints, usually in the hands, knees, hips, neck, and lower back. It's the most common type of arthritis. In a healthy joint, the ends of the bones are covered with a smooth, slippery tissue called cartilage. The cartilage pads the bones and helps them glide easily when you move the joint. With osteoarthritis, the cartilage breaks down and becomes rough. Sometimes, all the cartilage wears away and the bones rub together. Bumps of extra bone called bone spurs may grow in the joint area. There is no cure for osteoarthritis. It usually gets worse slowly. But there's a lot you can do to manage the symptoms. What are the symptoms of osteoarthritis? Osteoarthritis affects people in different ways, and not everyone has pain. The most common symptoms are: Pain when you move, which often gets better with rest Stiffness, especially for the first 30 minutes after you get up from resting Swollen joints, especially after using the joint a lot Less movement in the joint than normal A joint that feels loose or unstable What causes osteoarthritis? Researchers aren't sure what causes osteoarthritis. They think that it could be caused by a combination of factors in the body and the environment. Your chance of developing osteoarthritis increases with age. They also know that some people are more likely to develop it than others. Who is more likely to develop osteoarthritis? Things that make you more likely to develop osteoarthritis include: Aging. Osteoarthritis can happen at any age, but the chance of getting it increases in middle-aged adults and older. After age 50, it is more common in women than in men. Being overweight. Extra weight puts more stress on your joints. Having a past injury or surgery on a joint. This is often the cause of osteoarthritis in younger adults. Doing a lot of activities that overuse the joint. This includes sports with a lot of jumping, twisting, running, or throwing. Having a joint that doesn't line up correctly. A family history of osteoarthritis. Some people inherit genetic changes that increase their chance of developing osteoarthritis. How is osteoarthritis diagnosed? There is no specific test for osteoarthritis. To find out if you have osteoarthritis, your provider: Will ask about your symptoms and medical history Will do a physical exam May use x-rays or other imaging tests to look at your joints May order lab tests to make sure that a different problem isn't causing your symptoms What are the treatments for osteoarthritis? The goal of treating osteoarthritis is to ease your pain, help you move better, and stop it from getting worse. Treatment usually begins with: Exercises to improve strength, flexibility and balance Weight loss, if needed, to improve pain, especially in your hips or knees Braces or shoe inserts (orthotics) that a health care provider fits for you You can buy some pain relievers and arthritis creams without a prescription. They can be helpful, but it's best to talk to your provider about using them. If they don't help enough, your provider may prescribe injections (shots) into the joint or prescription pain relievers. Complementary therapies may help some people. Massage can increase blood flow and bring warmth to the area. Some research shows that acupuncture may help relieve osteoarthritis pain. Simple things like heat and ice can help, too. If none of these treatments help enough, surgery may be an option. You and your provider can decide if it's right for you. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary: Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including tremor, joint stiffness and back pain. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

MedlinePlus Genetics: 42 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.Osteoarthritis usually develops slowly, causing pain, stiffness, and restricted movement as the condition gets worse. Areas of bone no longer cushioned by cartilage rub against each other and start to break down. Further damage is caused as the body attempts to repair and rebuild these tissues. The immune system, which plays a role in healing injuries, targets these areas, and its response leads to inflammation of the joint tissues. Abnormal growths of bone (osteophytes) and other tissue can also occur, and may be visible as enlarged joints. Enlargement of the joints of the fingers is especially noticeable.People with osteoarthritis typically experience stiffness following periods of inactivity such as upon awakening or rising from a chair; the stiffness usually improves as they move around. In some affected individuals, the condition never causes major problems. In others, severe osteoarthritis can impair mobility and the ability to perform daily tasks, affecting quality of life and increasing the risk of other health conditions such as cardiovascular disease.Osteoarthritis is most common in middle age or late adulthood, because the cartilage at the joints naturally begins to thin as people age. However, it can occur earlier in life, especially after injuries affecting the joints such as a type of knee injury called an anterior cruciate ligament (ACL) tear. People who are overweight or whose activities are particularly stressful to the joints are also at increased risk of developing osteoarthritis.

CDC: 2 Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or "wear and tear" arthritis. It occurs most frequently in the hands, hips, and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

PubMed Health : 63 Osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age. If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Disease Ontology: 11 An arthritis that has material basis in worn out cartilage located in joint.

Wikipedia: 75 Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint... more...

Related Diseases for Osteoarthritis

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1458)
# Related Disease Score Top Affiliating Genes
1 cartilage disease 32.8 MMP13 GDF5 COMP COL2A1 ACAN
2 exostosis 32.5 MMP13 GDF5 COL2A1 ACAN
3 arthropathy 32.5 MMP13 COMP COL2A1 ACAN
4 arthritis 32.4 MMP13 COMP COL2A1 CILP ACAN
5 synovitis 32.3 MMP13 COMP COL2A1 ACAN
6 pseudoachondroplasia 32.3 COMP COL2A1 ACAN
7 osteochondritis dissecans 32.1 MMP13 COMP COL2A1 ACAN
8 rheumatoid arthritis 32.0 MMP13 HOTAIR H19 COMP COL2A1 CILP
9 spondylosis 31.9 GDF5 ACAN
10 kniest dysplasia 31.7 COMP COL2A1
11 bone disease 31.3 MMP13 GDF5 COMP COL2A1 ACAN
12 osteochondrosis 31.3 MMP13 COMP COL2A1 ACAN
13 spinal stenosis 31.2 MMP13 COL2A1 ACAN
14 degenerative disc disease 31.1 MMP13 GDF5 COL2A1 CILP ACAN
15 chondromalacia 31.1 COMP COL2A1 ACAN
16 spondylolisthesis 31.1 MMP13 GDF5 ACAN
17 tendinitis 31.0 MMP13 COMP ACAN
18 spondyloepiphyseal dysplasia with congenital joint dislocations 30.9 COMP COL2A1 ACAN
19 multiple epiphyseal dysplasia 30.9 COMP COL2A1 ACAN
20 septic arthritis 30.9 MMP13 ACAN
21 osteochondrodysplasia 30.8 MMP13 GDF5 COMP COL2A1 ACAN
22 bone inflammation disease 30.8 MMP13 COMP COL2A1 ACAN
23 coxa vara 30.7 MMP13 COL2A1
24 spondylolysis 30.6 GDF5 ACAN
25 achondroplasia 30.6 COMP COL2A1 ACAN
26 relapsing polychondritis 30.5 COMP COL2A1
27 brachydactyly 30.5 GDF5 COMP COL2A1 ACAN
28 brittle bone disorder 30.5 MMP13 COMP COL2A1 ACAN
29 fibrochondrogenesis 30.3 GDF5 COL2A1 ACAN
30 acromesomelic dysplasia 1 30.1 GDF5 COL2A1 ACAN
31 hypochondrogenesis 30.1 COMP COL2A1 ASPN ACAN
32 enchondromatosis, multiple, ollier type 30.1 MMP13 COL2A1 ACAN
33 spondyloepimetaphyseal dysplasia 30.0 MMP13 COL2A1 ACAN
34 pituitary adenoma 29.8 MEG3 HOTAIR H19
35 retinitis pigmentosa 11 29.5 KCNK15-AS1 HOTAIR GAS5
36 thyroid carcinoma 29.5 HOTAIR H19 GAS5
37 osteogenic sarcoma 29.2 PACERR MEG3 HOTAIR H19 GAS5
38 high grade glioma 29.0 PCGEM1 MEG3 HOTAIR H19 GAS5
39 progressive pseudorheumatoid dysplasia 11.7
40 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.7
41 loeys-dietz syndrome 3 11.7
42 multicentric osteolysis, nodulosis, and arthropathy 11.6
43 osteoarthritis with mild chondrodysplasia 11.5
44 behcet's syndrome arthropathy 11.4
45 spondyloepiphyseal dysplasia, stanescu type 11.4
46 transient arthropathy 11.4
47 myhre syndrome 11.4
48 czech dysplasia 11.3
49 beukes hip dysplasia 11.3
50 chondrocalcinosis 1 11.3

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 23)

Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Decubitus Ulcer
Deficiency Anemia Dysthymic Disorder
Esophagitis First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Iron Deficiency Anemia Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:

Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

UMLS symptoms related to Osteoarthritis:

tremor; joint stiffness; back pain; angina pectoris; arthralgia; sciatica; equilibration disorder; muscle cramp; metatarsalgia; joint symptom; musculoskeletal symptom; other symptoms referable to joint; stiffness of joint, not elsewhere classified in icd10cm; other symptoms referable to joint, shoulder region; other symptoms referable to joint, upper arm; other symptoms referable to joint, forearm; other symptoms referable to joint, hand; other symptoms referable to joint, pelvic region and thigh; other symptoms referable to joint, lower leg; other symptoms referable to joint, ankle and foot; other symptoms referable to joint, other specified sites; other symptoms referable to joint, multiple sites; other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Osteoarthritis:

# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.17 ACAN COL2A1 COMP FRZB GDF5 HOTAIR

Drugs & Therapeutics for Osteoarthritis

PubMed Health treatment related to Osteoarthritis: 63

There are many different suggestions and recommendations for treating osteoarthritis , but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible. There are two different types of therapies : Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy . The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle -strengthening exercises could help people with knee osteoarthritis . Other treatment options include massage , acupuncture , TENS, medicinal baths or orthopedic insoles. Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy ). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation . There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 576)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Chlorzoxazone Approved Phase 4 95-25-0 2733
Rivaroxaban Approved Phase 4 366789-02-8 9875401
Heparin, bovine Approved, Investigational, Withdrawn Phase 4 9005-49-6 22833565 9812414 772
Reviparin Approved, Investigational Phase 4 9041-08-1
Zoledronic acid Approved Phase 4 118072-93-8 68740
Liraglutide Approved Phase 4 204656-20-2 44147092 16134956
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Tacrine Approved, Investigational, Withdrawn Phase 4 321-64-2 1935
Glucosamine Approved, Investigational Phase 4 3416-24-8 318324 439213
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
Indian frankincense Approved, Experimental, Investigational Phase 4
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
Aceclofenac Approved, Investigational Phase 4 89796-99-6 71771
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
Chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
Duloxetine Approved Phase 4 136434-34-9, 116539-59-4 60835
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Norepinephrine Approved Phase 4 51-41-2 439260
Nabumetone Approved Phase 4 42924-53-8 4409
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
Cefuroxime Approved Phase 4 55268-75-2 5479529
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7, 53152-21-9 644073 40400
Remifentanil Approved Phase 4 132875-61-7 60815
Nimesulide Approved, Investigational, Withdrawn Phase 4 51803-78-2 4495
Methylene blue Approved, Investigational Phase 4 61-73-4 6099
Infliximab Approved Phase 4 170277-31-3
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
Milnacipran Approved, Investigational Phase 4 92623-85-3, 96847-54-0 11622909 65833 6917779
35 Orange Approved Phase 4
Zolpidem Approved Phase 4 82626-48-0 5732
Venlafaxine Approved Phase 4 99300-78-4, 93413-69-5 5656
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
Parecoxib Approved Phase 4 198470-84-7 119828
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
Vecuronium Approved, Investigational Phase 4 50700-72-6, 86029-43-8 39765 39764
Atropine Approved, Vet_approved Phase 4 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
Thrombin Approved, Investigational Phase 4
Desflurane Approved Phase 4 57041-67-5 42113
Prilocaine Approved Phase 4 721-50-6 4906
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Tranexamic acid Approved Phase 4 1197-18-8 5526
Cannabidiol Approved, Investigational Phase 4 13956-29-1 521372 644019
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
Ibuprofen Approved Phase 4 15687-27-1 3672

Interventional clinical trials:

(show top 50) (show all 4936)
# Name Status NCT ID Phase Drugs
1 Effect of Preoperative Intravenous Dexamethasone on Postoperative Pain After Primary Total Hip Arthroplasty : A Prospective, Double-blind, Randomized Controlled Trial Unknown status NCT03542617 Phase 4 Dexamethasone;Normal Saline Solution
2 The Effects of Tourniquet Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
3 Comparison of Therapeutic Effects of Hyaluronic Acid vs. Hyaluronic Acid Combined Corticosteroid on Knee Osteoarthritis: A Double Blind, Randomized-controlled Clinical Trial Unknown status NCT02625727 Phase 4
4 The Biomechanical Impact of Intra-Articular Hyaluronic Acid in Knee Osteoarthritis Patients: A Randomized, Double Blind, Placebo Controlled Study Unknown status NCT00778076 Phase 4
5 A Multicenter,Open-label Phase Ⅳ Trial of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
6 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
7 Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients Unknown status NCT04117893 Phase 4 Duloxetine;intra-articular injection of corticosteroid and hyaluronic acid
8 The Effect of Glucosamine Sulphate on Structural Disease Progression in Knee Osteoarthritis and the Cost-effectiveness of Glucosamine Sulphate for Knee Arthritis. Unknown status NCT00513422 Phase 4
9 Viscosupplementation in Patients With Severe Osteoarthritis of the Knee Unknown status NCT03090698 Phase 4 Hylan G-F 20;Triamcinolone
10 Additional Therapeutic Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis: a Double-blind, Randomized-controlled Clinical Trial Unknown status NCT04165902 Phase 4 compare the effects of steroid plus hyaluronic acid and destrose plus hyaluronic acid on knee osteroarthritis
11 Ultrasound Guided Adductor Canal Block vs Intra-Operative Trans-Articular Saphenous Nerve Block: A Prospective Trial Unknown status NCT04155983 Phase 4 Ropivacaine
12 Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty: A Randomized Controlled Study Unknown status NCT03792828 Phase 4 Duloxetine HCl 30mg
13 A Double-blind, Randomized, Controlled, Equivalence Study Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
14 Outcome Comparison of Allogenic Cancellous Bone and a New Synthetic Bone Substitute (geneX®) in Filling the Bone Defect Created With Medial Open Wedge High Tibial Osteotomy Unknown status NCT02000297 Phase 4
15 Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients: A Randomized Controlled Study Unknown status NCT03109652 Phase 4 Tranexamic Acid
16 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
17 Additional Therapeutic Effects of Dextrose to Hyaluronic Acid on Knee Osteoarthritis: a Double Blind, Randomized-controlled Clinical Trial Unknown status NCT03238183 Phase 4 dextrose
18 Effect of Postoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty : A Randomized, Controlled, Double-Blind Trial Unknown status NCT03561480 Phase 4 Ferric carboxymaltose;0.9% Normal Saline
19 A Multicentre, Randomized, Double-blinded, Parallel-controlled, Non-inferiority Clinical Study Of Safety and Efficacy Of Medical Chitosan for Knee Osteoarthritis Compared With Sodium Hyaluronate Injection Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
20 Intra-articular Botulinum Toxin Type A Versus Corticosteroids: a Clinical Trial in Osteoarthritis of Knees Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
21 Intra-Articular Injections of Hyaluronan Versus 20 Ml NaCl Versus Placebo in Treatment of Knee Osteoarthritis: a Randomised, Double-Blind, Placebo Controlled Single Centre Trial. Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
22 A Multi-center, Randomized, Open-label, Parallel-arm Controlled Study Comparing Demand-based Monotherapy of Non-steroidal Anti-inflammatory Drug (NSAID) vs. Demand-based NSAID Combined With Sodium Hyaluronate Injection in the Treatment of Chinese Patients With Mild to Moderate Knee Osteoarthritis Unknown status NCT02826031 Phase 4 Sodium Hyaluronate Injection;DICL-SR
23 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex and AGC Unknown status NCT00294528 Phase 4
24 A Prospective, Randomized, Double-blinded, Multi-center, Trial to Evaluate Efficacy and Safety of Combination of Diacerein and Celecoxib Administered Orally in Patients With Knee Osteoarthritis Unknown status NCT03404479 Phase 4 Diacerein;Celecoxib
25 Effect of Preoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty : A Randomized, Controlled, Double-Blind Trial Unknown status NCT03561506 Phase 4 Ferric carboxymaltose;0.9% Normal Saline
26 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
27 A Randomized, Double Blind, Single Simulation, Parallel Controlled, Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
28 Randomized, Double-blind, Placebo-controlled Study to Asses the Effect of Chondroitin Sulphate in Patients With Knee Osteoarthritis by Functional Magnetic Resonance Imaging Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
29 Influence of Perception of Patients Suffering of Osteoarthritis of Knee Over the Effectiveness and Tolerance in Intra-articular Injection of Corticoids: a Prospective, Controlled and Randomized Study Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
30 Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis: A Randomized Double-blind, Saline-controlled Trial Unknown status NCT03484091 Phase 4 Hyruan-One;Hylan G-F 20;Normal saline
31 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty - Randomized Prospective Study Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
32 Additional Therapeutic Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis: A Double Blind, Randomized-controlled Clinical Trial Unknown status NCT02949466 Phase 4 Triamcinolone
33 Serum Calprotectin Level in Patients With Rheumatoid Arthritis and Osteoarthritis Unknown status NCT04201886 Phase 4
34 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
35 A Prospective, Randomized, Double-blinded, Double-dummy, Active-controlled, Multi-center, Interventional Study to Compare Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
36 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
37 Prospective, Single Arm, Pilot Study Evaluating the Safety and Efficacy of Hyaluronan (Hylan GF-20) in Patients With Painful Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
38 Double-blind, Randomised, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of the Combination of Chondroitin Sulphate and Glucosamine Hydrochloride in Patients With Hand Osteoarthritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
39 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
40 Comparison of the Analgesic Efficacy of Continuous Femoral Nerve Block and Adductor Canal Block With Steroid Adjuvant in Patients Undergoing Total Knee Arthroplasty Unknown status NCT01973530 Phase 4
41 Investigating the Use of a Cryopneumatic Therapy Device in Primary Total Knee Arthroplasty Patients Unknown status NCT00712816 Phase 4
42 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
43 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
44 A Randomized Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery. Influence on Operative Result, Health-Related Quality of Life, and Coordinative Abilities. Unknown status NCT00431509 Phase 4
45 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
46 A 26 Week Multicenter Prospective Open Label Clinical Study Evaluating a Single Intra-articular Injection of DUROLANE SJ1ml for Treatment of OA Pain of the Ankle Unknown status NCT02627859 Phase 4
47 Does Intraoperative Intravenous Iron Sucrose Enhance Postoperative Oxygenation Profile in Total Arthroplasty Surgery? Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
48 Intraoperative IV Iron on the Postoperative Recovery of Red Blood Cell in Hip Arthroplasty Surgery Unknown status NCT04035902 Phase 4 Ferric carboxymaltose;control
49 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
50 Artelon MTP Spacer - Surgical Treatment of Mild to Moderate Hallux Rigidus Unknown status NCT01028469 Phase 4

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :

choline salicylate
Chondroitin Sulfates
Diclofenac Potassium
Diclofenac Sodium
Fenoprofen Calcium
Flurbiprofen sodium
Naproxen sodium
Tolmetin Sodium

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem-derived chondrocytes for treatment of osteochondral defects
AlloStem, adipose-derived mesenchymal stem cells combined with allograft bone for bone grafting
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel, autologous cultured chondrocytes for treatment of cartilage defects
CARTISTEM, mesenchymal stem cells for treatment of osteoarthritis
Chondrocell, bone marrow-derived mesenchymal stem cells for osteoarthritis
Chondrogen, mesenchymal stem cells for meniscus regeneration and knee osteoarthritis prevention
HiQCell, adipose-derived stromal vascular fraction for osteoarthritis
JACC, cultured cartilage for chondral lesion
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem, adipose-derived mesenchymal stem cells for degenerative arthritis
StempeucelOA, mesenchymal stem cells for treatment of osteoarthritis
Trinity Evolution, mesenchymal stem cells with osteoprogenitors for musculoskeletal defects
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem 4D20.8, NCr-fac Progenitor PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem) PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel) PMIDs: 17515233 16510814 17590152
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 12708651 19530993 14673997 10102814
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC) PMIDs: 19393556 10738867 16226641 12043781 16233853 10679677 16233778 19802670 11284883
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel) PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity Evolution) PMIDs: 20508015 21056860

Cochrane evidence based reviews: osteoarthritis

Genetic Tests for Osteoarthritis

Genetic tests related to Osteoarthritis:

# Genetic test Affiliating Genes
1 Osteoarthritis 28

Anatomical Context for Osteoarthritis

Organs/tissues related to Osteoarthritis:

FMA: Joint
MalaCards : Bone Marrow, Bone, Skin, Brain, Skeletal Muscle, Dorsal Root Ganglion, Placenta
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Temporomandibular Joint Affected by disease
2 Bone Vertebrae Affected by disease
3 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
4 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
5 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
6 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
7 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
8 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
9 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Osteoarthritis

Articles related to Osteoarthritis:

(show top 50) (show all 45901)
# Title Authors PMID Year
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 62 5
15210948 2004
Endoscopic Surgical Treatment of Osteoarthritis and Prognostic Model Construction. 62 41
36105246 2022
Effects of complex spa therapy in patients with osteoarthritis of the spine receiving treatments in health resorts in south-eastern Poland. 41
36038633 2022
Comparison of Clinical and Radiological Outcomes between Calibratable Patient-Specific Instrumentation and Conventional Operation for Medial Open-Wedge High Tibial Osteotomy: A Randomized Controlled Trial. 41
36467884 2022
Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. 53 62
20206313 2010
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. 53 62
20495570 2010
A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. 53 62
19756630 2010
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. 53 62
20131257 2010
A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. 53 62
20175976 2010
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. 53 62
19902332 2010
Premature arthritis is a distinct type II collagen phenotype. 53 62
20131279 2010
Changes in content and synthesis of collagen types and proteoglycans in osteoarthritis of the knee joint and comparison of quantitative analysis with Photoshop-based image analysis. 53 62
19838720 2010
High specificity but low sensitivity of the cartilage oligomeric matrix protein (COMP) test in rheumatoid arthritis and osteoarthritis. 53 62
20148721 2010
Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. 53 62
20131253 2010
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro. 53 62
19890996 2010
[Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis]. 53 62
20423837 2010
The genetic epidemiology of osteoarthritis. 53 62
20090528 2010
A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils. 53 62
20077500 2010
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis. 53 62
20112374 2010
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. 53 62
19679221 2010
The transcript level of interleukin-6 in the cartilage of idiopathic osteoarthritis of knee. 53 62
20393674 2010
[Detection of bone erosions in knee osteoarthrosis by serum biomarkers]. 53 62
20422912 2010
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis. 53 62
19762475 2009
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. 53 62
19054821 2009
Modulating hedgehog signaling can attenuate the severity of osteoarthritis. 53 62
19915594 2009
Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. 53 62
20021689 2009
Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation. 53 62
19877068 2009
Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study. 53 62
19029166 2009
Asporin and transforming growth factor-beta gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis. 53 62
19997821 2009
Elevated circulating and synovial fluid endoglin are associated with primary knee osteoarthritis severity. 53 62
20082874 2009
COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women. 53 62
19019890 2009
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. 53 62
19684582 2009
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. 53 62
19274754 2009
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. 53 62
19268722 2009
Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. 53 62
19682376 2009
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. 53 62
19606871 2009
The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene. 53 62
19486942 2009
Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis. 53 62
19602530 2009
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models. 53 62
19565489 2009
Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. 53 62
19565498 2009
Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. 53 62
19565481 2009
Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis. 53 62
19217805 2009
Pretreatment insulin-like growth factor-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease. 53 62
19366851 2009
Fibroblast growth factor 2: A new key player in osteoarthritis. 53 62
19565484 2009
Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. 53 62
19091605 2009
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. 53 62
19494318 2009
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. 53 62
19479880 2009
The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment. 53 62
18926729 2009
A large kindred of early-onset osteoarthritis of the knee and hip: excluding the link to COL2A1 gene. 53 62
19223283 2009
[Determination of the concentrations of interleukin-18 and other cytokines in the synovial fluid in patients with osteoarthritis]. 53 62
19403407 2009

Variations for Osteoarthritis

ClinVar genetic disease variations for Osteoarthritis:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TLR8, TLR8-AS1 NM_138636.5(TLR8):c.-180G>C SNV Association
590975 rs1569113445 GRCh37: X:12924646-12924646
GRCh38: X:12906527-12906527
2 TLR8, TLR8-AS1 NM_138636.5(TLR8):c.-169T>A SNV Association
590976 rs1569113447 GRCh37: X:12924657-12924657
GRCh38: X:12906538-12906538
3 FRZB NM_001463.4(FRZB):c.970C>G (p.Arg324Gly) SNV Risk Factor
5220 rs7775 GRCh37: 2:183699584-183699584
GRCh38: 2:182834857-182834857
4 FRZB NM_001463.4(FRZB):c.598C>T (p.Arg200Trp) SNV Risk Factor
5221 rs288326 GRCh37: 2:183703336-183703336
GRCh38: 2:182838608-182838608
5 FRZB NM_001463.4(FRZB):c.282del (p.Ile95fs) DEL Uncertain Significance
522886 rs1553503725 GRCh37: 2:183730999-183730999
GRCh38: 2:182866271-182866271

Expression for Osteoarthritis

LifeMap Discovery
Genes differentially expressed in tissues of Osteoarthritis patients vs. healthy controls: 35 (show top 50) (show all 60)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CYP4B1 cytochrome P450 family 4 subfamily B member 1 Cartilage - 6.04 0.000
2 FOSB FosB proto-oncogene, AP-1 transcription factor subunit Cartilage - 5.13 0.000
3 IGL immunoglobulin lambda locus Cartilage + 5.03 0.000
4 MAFF MAF bZIP transcription factor F Cartilage - 4.56 0.000
5 ANGPTL7 angiopoietin like 7 Cartilage - 4.42 0.000
6 LTC4S leukotriene C4 synthase Cartilage + 4.42 0.000
7 IGKC immunoglobulin kappa constant Cartilage + 4.31 0.000
8 JCHAIN joining chain of multimeric IgA and IgM Cartilage + 4.29 0.000
9 FAM107A family with sequence similarity 107 member A Cartilage - 4.26 0.000
10 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 Cartilage + 4.25 0.001
11 MMP1 matrix metallopeptidase 1 Cartilage + 4.23 0.000
12 IGLJ3 immunoglobulin lambda joining 3 Cartilage + 4.05 0.000
13 APOD apolipoprotein D Cartilage - 4.05 0.000
14 JUN Jun proto-oncogene, AP-1 transcription factor subunit Cartilage - 4.03 0.000
15 NFIL3 nuclear factor, interleukin 3 regulated Cartilage - 3.80 0.000
16 SLC2A3 solute carrier family 2 member 3 Cartilage - 3.76 0.000
17 SLCO4A1 solute carrier organic anion transporter family member 4A1 Cartilage - 3.73 0.000
18 TPPP3 tubulin polymerization promoting protein family member 3 Cartilage + 3.70 0.000
19 GADD45B growth arrest and DNA damage inducible beta Cartilage - 3.66 0.000
20 CXCL2 C-X-C motif chemokine ligand 2 Cartilage - 3.66 0.000
21 IGHM immunoglobulin heavy constant mu Cartilage + 3.62 0.000
22 CSN1S1 casein alpha s1 Cartilage + 3.58 0.008
23 CXCL8 C-X-C motif chemokine ligand 8 Cartilage - 3.56 0.000
24 CXCL3 C-X-C motif chemokine ligand 3 Cartilage - 3.55 0.000
25 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide Cartilage - 3.55 0.000
26 FOSL2 FOS like 2, AP-1 transcription factor subunit Cartilage - 3.54 0.000
27 VEGFA vascular endothelial growth factor A Cartilage - 3.54 0.000
28 IGLV2-23 immunoglobulin lambda variable 2-23 Cartilage + 3.53 0.001
29 FKBP5 FKBP prolyl isomerase 5 Cartilage - 3.52 0.003
30 ADCY2 adenylate cyclase 2 Cartilage - 3.50 0.000
31 CX3CR1 C-X3-C motif chemokine receptor 1 Cartilage + 3.47 0.000
32 IGKV1-5 immunoglobulin kappa variable 1-5 Cartilage + 3.39 0.000
33 MXRA5 matrix remodeling associated 5 Cartilage + 3.38 0.000
34 APOLD1 apolipoprotein L domain containing 1 Cartilage - 3.37 0.000
35 TNFSF11 TNF superfamily member 11 Cartilage + 3.36 0.000
36 SIK1 salt inducible kinase 1 Cartilage - 3.34 0.000
37 DDIT4 DNA damage inducible transcript 4 Cartilage - 3.33 0.000
38 GAP43 growth associated protein 43 Cartilage + 3.31 0.001
39 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 Cartilage - 3.29 0.000
40 OGN osteoglycin Cartilage + 3.28 0.001
41 MUC1 mucin 1, cell surface associated Cartilage - 3.27 0.000
42 PTGS2 prostaglandin-endoperoxide synthase 2 Cartilage - 3.27 0.000
43 DUSP2 dual specificity phosphatase 2 Cartilage - 3.25 0.000
44 CD52 CD52 molecule Cartilage + 3.21 0.000
45 PLXNC1 plexin C1 Cartilage + 3.20 0.000
46 SOD2 superoxide dismutase 2 Cartilage - 3.20 0.000
47 SDC1 syndecan 1 Cartilage + 3.19 0.000
48 CEBPD CCAAT enhancer binding protein delta Cartilage - 3.18 0.000
49 NR4A2 nuclear receptor subfamily 4 group A member 2 Cartilage - 3.18 0.000
50 ATF3 activating transcription factor 3 Cartilage - 3.18 0.000
Search GEO for disease gene expression data for Osteoarthritis.

Pathways for Osteoarthritis

GO Terms for Osteoarthritis

Cellular components related to Osteoarthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.65 COMP COL2A1 CILP ASPN ACAN
2 extracellular matrix GO:0031012 9.32 MMP13 COMP COL2A1 ASPN ACAN

Biological processes related to Osteoarthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.65 COMP COL2A1 ACAN
2 cartilage development GO:0051216 9.62 GDF5 COMP COL2A1
3 growth plate cartilage development GO:0003417 9.46 MMP13 COMP
4 bone mineralization GO:0030282 9.43 MMP13 COMP ASPN
5 skeletal system development GO:0001501 9.23 FRZB COMP COL2A1 ACAN

Molecular functions related to Osteoarthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteoglycan binding GO:0043394 9.46 COMP COL2A1
2 collagen binding GO:0005518 9.43 MMP13 COMP ASPN
3 extracellular matrix structural constituent GO:0005201 9.23 COMP COL2A1 CILP ACAN

Sources for Osteoarthritis

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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