OA
MCID: OST012
MIFTS: 78

Osteoarthritis (OA)

Categories: Bone diseases, Muscle diseases

Aliases & Classifications for Osteoarthritis

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 12 74 25 29 54 6 42 3 43 15 37 62 39 17
Osteoarthrosis 12 25 15
Degenerative Joint Disease 12 25
Degenerative Polyarthritis 25 71
Hypertrophic Arthritis 12 25
Arthropathy 25 71
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 25
Osteoarthrosis Deformans 71
Arthritis, Degenerative 25
Degenerative Arthritis 12
Kashin-Beck Disease 71
Oa 25

Characteristics:


Classifications:



External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 34 715.3
MeSH 43 D010003
SNOMED-CT via HPO 68 239872002 258211005 263681008
UMLS 71 C0022408 C0029408 C0086743 more

Summaries for Osteoarthritis

Genetics Home Reference : 25 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips. Osteoarthritis usually develops slowly, causing pain, stiffness, and restricted movement as the condition gets worse. Areas of bone no longer cushioned by cartilage rub against each other and start to break down. Further damage is caused as the body attempts to repair and rebuild these tissues. The immune system, which plays a role in healing injuries, targets these areas, and its response leads to inflammation of the joint tissues. Abnormal growths of bone (osteophytes) and other tissue can also occur, and may be visible as enlarged joints. Enlargement of the joints of the fingers is especially noticeable. People with osteoarthritis typically experience stiffness following periods of inactivity such as upon awakening or rising from a chair; the stiffness usually improves as they move around. In some affected individuals, the condition never causes major problems. In others, severe osteoarthritis can impair mobility and the ability to perform daily tasks, affecting quality of life and increasing the risk of other health conditions such as cardiovascular disease. Osteoarthritis is most common in middle age or late adulthood, because the cartilage at the joints naturally begins to thin as people age. However, it can occur earlier in life, especially after injuries affecting the joints such as a type of knee injury called an anterior cruciate ligament (ACL) tear. People who are overweight or whose activities are particularly stressful to the joints are also at increased risk of developing osteoarthritis.

MalaCards based summary : Osteoarthritis, also known as osteoarthrosis, is related to pseudoachondroplasia and diastrophic dysplasia, and has symptoms including tremor, joint stiffness and arthralgia. An important gene associated with Osteoarthritis is FRZB (Frizzled Related Protein), and among its related pathways/superpathways are Degradation of the extracellular matrix and Endochondral Ossification. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotypes are hip osteoarthritis and abnormality of pelvic girdle bone morphology

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

MedlinePlus : 42 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint No single test can diagnose osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or "wear and tear" arthritis. It occurs most frequently in the hands, hips, and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

PubMed Health : 62 About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age. If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 74 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Related Diseases for Osteoarthritis

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 1168, show less)
# Related Disease Score Top Affiliating Genes
1 pseudoachondroplasia 33.4 MATN3 COMP COL2A1 ACAN
2 diastrophic dysplasia 33.2 MATN3 COMP COL2A1
3 cartilage disease 33.1 COMP COL2A1 ACAN
4 epiphyseal dysplasia, multiple, 2 32.9 MATN3 COMP
5 epiphyseal dysplasia, multiple, 1 32.7 MATN3 COMP
6 epiphyseal dysplasia, multiple, 5 32.5 MATN3 COMP
7 synovitis 32.4 COMP COL2A1 ACAN
8 rheumatoid arthritis 32.4 HOTAIR H19 COMP COL2A1 CILP ACAN
9 arthropathy 32.1 COMP COL2A1 ACAN
10 back pain 32.1 CILP ASPN
11 bone disease 31.4 MATN3 GDF5 COMP COL2A1 ACAN
12 osteochondritis dissecans 31.4 MATN3 COMP ACAN
13 spondyloepiphyseal dysplasia with congenital joint dislocations 31.3 COMP COL2A1 ACAN
14 degenerative disc disease 31.3 GDF5 ASPN ACAN
15 chondromalacia 31.3 COMP ACAN
16 multiple epiphyseal dysplasia 31.2 MATN3 COMP COL2A1 ACAN
17 multiple epiphyseal dysplasia, autosomal dominant 31.1 MATN3 COMP
18 spondylolisthesis 31.1 GDF5 ACAN
19 spondyloepiphyseal dysplasia congenita 31.0 MATN3 COMP COL2A1
20 stickler syndrome 31.0 MATN3 COL2A1 ACAN
21 bone inflammation disease 31.0 COMP COL2A1 ACAN
22 achondroplasia 30.9 COMP COL2A1 ACAN
23 brachydactyly 30.9 GDF5 COMP COL2A1 ACAN
24 skeletal dysplasias 30.8 MATN3 COMP COL2A1
25 osteochondrosis 30.8 COL2A1 ACAN
26 brittle bone disorder 30.6 COMP COL2A1 ACAN
27 fibrochondrogenesis 30.5 GDF5 COL2A1 ACAN
28 spondyloepimetaphyseal dysplasia, matrilin-3 related 30.4 MATN3 COMP COL2A1 ACAN
29 hypochondrogenesis 30.4 COL2A1 ACAN
30 odontochondrodysplasia 30.4 MATN3 GDF5 COMP COL2A1 ACAN
31 otospondylomegaepiphyseal dysplasia 30.3 COMP COL2A1
32 pituitary adenoma 29.5 MEG3 HOTAIR H19
33 glioma susceptibility 1 29.4 MEG3 HOTAIR H19 GAS5
34 myeloma, multiple 28.7 MEG3 HOTAIR H19 GAS5
35 malignant glioma 28.5 PCGEM1 MEG3 HOTAIR H19 GAS5
36 osteogenic sarcoma 28.4 PACERR MEG3 HOTAIR H19 GAS5 FRZB
37 multicentric osteolysis, nodulosis, and arthropathy 12.8
38 arthropathy, progressive pseudorheumatoid, of childhood 12.7
39 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.7
40 osteoarthritis with mild chondrodysplasia 12.7
41 behcet's syndrome arthropathy 12.3
42 arthropathy, erosive 12.3
43 multicentric osteolysis-nodulosis-arthropathy spectrum 12.3
44 loeys-dietz syndrome 3 12.3
45 transient arthropathy 12.3
46 czech dysplasia 12.2
47 obsolete: progeria-associated arthropathy 12.1
48 chondrocalcinosis 2 12.1
49 myhre syndrome 12.1
50 familial osteochondritis dissecans 12.1
51 esophageal atresia 11.9
52 chondrocalcinosis 1 11.8
53 beukes hip dysplasia 11.8
54 jaccoud's syndrome 11.7
55 mitochondrial dna depletion syndrome 6 11.7
56 microphthalmia with limb anomalies 11.6
57 anophthalmos with limb anomalies 11.6
58 otospondylomegaepiphyseal dysplasia, autosomal recessive 11.6
59 hemochromatosis, type 2a 11.6
60 spondylosis 11.5
61 arthritis 11.5
62 loeys-dietz syndrome 11.5
63 spondyloepiphyseal dysplasia tarda, x-linked 11.5
64 developmental dysplasia of the hip 1 11.5
65 winchester syndrome 11.5
66 wild type abeta2m amyloidosis 11.5
67 cinca syndrome 11.4
68 fibromyalgia 11.4
69 mandibuloacral dysplasia with type a lipodystrophy 11.4
70 hemochromatosis type 2 11.4
71 primary hypertrophic osteoarthropathy 11.4
72 endosteal hyperostosis, autosomal dominant 11.4
73 legg-calve-perthes disease 11.4
74 alkaptonuria 11.4
75 ochronosis 11.4
76 ehlers-danlos syndrome 11.4
77 hypophosphatemia 11.4
78 occipital neuralgia 11.4
79 brachyolmia type 3 11.3
80 spondyloepiphyseal dysplasia, stanescu type 11.3
81 renal tubular acidosis, proximal, with ocular abnormalities and mental retardation 11.2
82 wolfram syndrome 11.2
83 otospondylomegaepiphyseal dysplasia, autosomal dominant 11.2
84 spondyloepimetaphyseal dysplasia with joint laxity, type 2 11.2
85 digital arthropathy-brachydactyly, familial 11.2
86 ehlers-danlos syndrome, classic-like, 2 11.2
87 mucopolysaccharidosis, type vi 11.1
88 cdags syndrome 11.1
89 atransferrinemia 11.1
90 xanthinuria, type i 11.1
91 xanthinuria, type ii 11.1
92 hemochromatosis, type 2b 11.1
93 brachydactylous dwarfism mseleni type 11.1
94 angel-shaped phalangoepiphyseal dysplasia 11.0
95 stickler syndrome, type i 11.0
96 osteomesopyknosis 11.0
97 osteopetrosis, autosomal dominant 2 11.0
98 spondyloepiphyseal dysplasia tarda, autosomal dominant 11.0
99 spondylometaphyseal dysplasia, kozlowski type 11.0
100 desbuquois dysplasia 1 11.0
101 spondyloepimetaphyseal dysplasia, missouri type 11.0
102 stickler syndrome, type i, nonsyndromic ocular 11.0
103 developmental dysplasia of the hip 2 11.0
104 ocular albinism 11.0
105 klippel-feil syndrome 11.0
106 central cord syndrome 11.0
107 exostosis 11.0
108 chronic pain 10.9
109 osteoporosis 10.8
110 bone mineral density quantitative trait locus 8 10.8
111 bone mineral density quantitative trait locus 15 10.8
112 rapidly involuting congenital hemangioma 10.8
113 acute tympanitis 10.7 MATN3 GDF5 ASPN
114 body mass index quantitative trait locus 1 10.7
115 rheumatic disease 10.7
116 transient arthritis 10.7
117 achondrogenesis, type ii 10.7 COMP COL2A1 ACAN
118 achondrogenesis 10.7 MATN3 COMP COL2A1 ACAN
119 bone resorption disease 10.7
120 bone deterioration disease 10.7 GDF5 COL2A1 CILP ACAN
121 bone structure disease 10.7 GDF5 COL2A1 CILP ACAN
122 bone development disease 10.6 MATN3 GDF5 COMP COL2A1 ACAN
123 chondrodysplasia, grebe type 10.6 GDF5 COL2A1
124 enthesopathy 10.6
125 chondrocalcinosis 10.6
126 syringomyelia, noncommunicating isolated 10.6
127 syringomyelia 10.6
128 osteonecrosis 10.6
129 body mass index quantitative trait locus 11 10.6
130 palindromic rheumatism 10.6
131 body mass index quantitative trait locus 9 10.6
132 body mass index quantitative trait locus 8 10.6
133 body mass index quantitative trait locus 4 10.6
134 body mass index quantitative trait locus 10 10.6
135 body mass index quantitative trait locus 7 10.6
136 body mass index quantitative trait locus 12 10.6
137 body mass index quantitative trait locus 14 10.6
138 body mass index quantitative trait locus 18 10.6
139 body mass index quantitative trait locus 19 10.6
140 body mass index quantitative trait locus 20 10.6
141 simpson-golabi-behmel syndrome, type 1 10.5 COL2A1 ACAN
142 psoriatic arthritis 10.5
143 gout 10.5
144 cytokine deficiency 10.5
145 inflammatory spondylopathy 10.5
146 spondylitis 10.5
147 aging 10.5
148 spondyloarthropathy 1 10.5
149 septic arthritis 10.5
150 acromesomelic dysplasia 10.5 GDF5 COL2A1
151 kashin-beck disease 10.4
152 constipation 10.4
153 rickets 10.4
154 brachyolmia 10.4 COL2A1 ACAN
155 frozen shoulder 10.4
156 bursitis 10.4
157 hydrops, lactic acidosis, and sideroblastic anemia 10.4
158 lipid metabolism disorder 10.4
159 48,xyyy 10.4
160 pain agnosia 10.4
161 avascular necrosis 10.4
162 chondrosarcoma 10.4
163 47,xyy 10.4
164 proteasome-associated autoinflammatory syndrome 1 10.4
165 pik3ca-related overgrowth syndrome 10.4
166 tabes dorsalis 10.3
167 osteomyelitis 10.3
168 ankylosis 10.3
169 tendinitis 10.3
170 triiodothyronine receptor auxiliary protein 10.3
171 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
172 tumoral calcinosis, hyperphosphatemic, familial, 1 10.3
173 intermittent hydrarthrosis 10.3
174 autosomal recessive disease 10.3
175 paraplegia 10.3
176 rare disease in surgical orthopedic 10.3
177 thrombophilia due to thrombin defect 10.3
178 exanthem 10.3
179 spinal stenosis 10.3
180 autoimmune disease 10.3
181 cystic fibrosis 10.3
182 vasculitis 10.3
183 diabetes mellitus 10.3
184 tenosynovitis 10.3
185 sarcoidosis 1 10.3
186 syphilis 10.3
187 idiopathic avascular necrosis 10.2
188 hand skill, relative 10.2
189 insulin-like growth factor i 10.2
190 allergic hypersensitivity disease 10.2
191 b-cell lymphoma 10.2
192 muscular atrophy 10.2
193 slipped capital femoral epiphysis 10.2
194 aneurysm 10.2
195 t-cell leukemia 10.2
196 anxiety 10.2
197 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
198 diarrhea 10.2
199 neuropathy 10.2
200 functionless pituitary adenoma 10.2 MEG3 HOTAIR
201 hypercholesterolemia, familial, 1 10.2
202 spondyloarthropathy 10.2
203 hyperostosis 10.2
204 peptic ulcer disease 10.2
205 atherosclerosis susceptibility 10.2
206 reactive arthritis 10.2
207 bunion 10.2
208 hypoxia 10.2
209 paresthesia 10.2
210 crohn's disease 10.2
211 rubella 10.2
212 popliteal cyst 10.2
213 acrocallosal syndrome 10.2
214 hemochromatosis, type 1 10.2
215 sclerosteosis 10.2
216 hyperglycemia 10.2
217 peripheral nervous system disease 10.2
218 active peptic ulcer disease 10.2
219 pulmonary embolism 10.2
220 hypermobile ehlers-danlos syndrome 10.2
221 tumoral calcinosis, normophosphatemic, familial 10.2
222 familial tumoral calcinosis 10.2
223 hemophilia b 10.1
224 pain sensitivity quantitative trait locus 1 10.1
225 autonomic neuropathy 10.1
226 carpal tunnel syndrome 10.1
227 mammary paget's disease 10.1
228 gastritis 10.1
229 sleep disorder 10.1
230 systemic lupus erythematosus 10.1
231 coronary heart disease 1 10.1
232 tendinopathy 10.1
233 hyperuricemia 10.1
234 depression 10.1
235 overgrowth syndrome 10.1
236 colitis 10.1
237 polyneuropathy 10.1
238 lipomatosis, multiple 10.1
239 muscle hypertrophy 10.1
240 pleomorphic lipoma 10.1
241 acromegaly 10.1
242 congestive heart failure 10.1
243 adult t-cell leukemia 10.1
244 myopathy 10.1
245 chiari malformation 10.1
246 leech infestation 10.1
247 vascular disease 10.1
248 connective tissue disease 10.1
249 dwarfism 10.1
250 hereditary sensory neuropathy 10.1
251 asymptomatic neurosyphilis 10.1
252 neurosyphilis 10.1
253 esophagus squamous cell carcinoma 10.0 MEG3 HOTAIR
254 leptin deficiency or dysfunction 10.0
255 scoliosis 10.0
256 hypermobility syndrome 10.0
257 cerebral palsy 10.0
258 complex regional pain syndrome 10.0
259 skin disease 10.0
260 spondylarthropathy 10.0
261 trochlear dysplasia 10.0
262 thyroid cancer, nonmedullary, 1 10.0 HOTAIR H19 GAS5
263 primary biliary cirrhosis 10.0
264 heart valve disease 10.0
265 non-alcoholic fatty liver disease 10.0
266 fatty liver disease 10.0
267 coxa vara 10.0
268 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 10.0
269 migraine with or without aura 1 10.0
270 arterial calcification, generalized, of infancy, 1 10.0
271 reflex sympathetic dystrophy 10.0
272 bone mineral density quantitative trait locus 3 10.0
273 creatinine clearance quantitative trait locus 10.0
274 myocardial infarction 10.0
275 leukemia, acute lymphoblastic 3 10.0
276 heart disease 10.0
277 osteopetrosis 10.0
278 algoneurodystrophy 10.0
279 hypothyroidism 10.0
280 mental depression 10.0
281 duodenal ulcer 10.0
282 hyperinsulinism 10.0
283 liver disease 10.0
284 systemic scleroderma 10.0
285 radiculopathy 10.0
286 severe combined immunodeficiency 10.0
287 juvenile rheumatoid arthritis 10.0
288 psoriasis 10.0
289 crystal arthropathies 10.0
290 synovial chondromatosis 10.0
291 premature aging 10.0
292 spondylolysis 10.0
293 celiac disease 1 10.0
294 sjogren syndrome 10.0
295 cauda equina syndrome 10.0
296 iridocyclitis 10.0
297 hypocomplementemic urticarial vasculitis 10.0
298 splenomegaly 10.0
299 raynaud phenomenon 10.0
300 hip subluxation 10.0
301 arts syndrome 10.0
302 pulmonary disease, chronic obstructive 10.0
303 angina pectoris 10.0
304 sleep apnea 10.0
305 spinal disease 10.0
306 coronary artery anomaly 10.0
307 leukemia 10.0
308 acute cystitis 10.0
309 periarthritis 10.0
310 pustulosis of palm and sole 10.0
311 hydrarthrosis 10.0
312 periodontitis 10.0
313 amyloidosis 10.0
314 fasciitis 10.0
315 plantar fasciitis 10.0
316 osteochondroma 10.0
317 gastric cardia adenocarcinoma 10.0 MEG3 HOTAIR H19
318 acroosteolysis 9.9
319 keratitis, hereditary 9.9
320 chiari malformation type ii 9.9
321 beta-thalassemia 9.9
322 hemopericardium 9.9
323 pericardial effusion 9.9
324 dysentery 9.9
325 glomerulonephritis 9.9
326 mixed connective tissue disease 9.9
327 polyarteritis nodosa 9.9
328 spastic paraparesis 9.9
329 neurofibromatosis, type ii 9.9
330 arteries, anomalies of 9.9
331 proline-negative auxotroph of hamster, complementation of 9.9
332 protrusio acetabuli 9.9
333 scleroderma, familial progressive 9.9
334 tuberous sclerosis 1 9.9
335 paine syndrome 9.9
336 mycobacterium tuberculosis 1 9.9
337 avascular necrosis of femoral head, primary, 1 9.9
338 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
339 hyperlipoproteinemia, type iii 9.9
340 helix syndrome 9.9
341 restless legs syndrome 9.9
342 peripheral artery disease 9.9
343 thrombosis 9.9
344 fibrous dysplasia 9.9
345 endocarditis 9.9
346 nasopharyngitis 9.9
347 osteomalacia 9.9
348 glucose intolerance 9.9
349 gastric ulcer 9.9
350 brucellosis 9.9
351 hemosiderosis 9.9
352 tuberous sclerosis 9.9
353 hyperparathyroidism 9.9
354 neurogenic arthropathy 9.9
355 alcohol use disorder 9.9
356 transient cerebral ischemia 9.9
357 mood disorder 9.9
358 thrombophlebitis 9.9
359 paget's disease of bone 9.9
360 diffuse idiopathic skeletal hyperostosis 9.9
361 cerebrovascular disease 9.9
362 lupus erythematosus 9.9
363 diabetic neuropathy 9.9
364 hemophilia 9.9
365 sickle cell disease 9.9
366 chromosomal triplication 9.9
367 spinal cord injury 9.9
368 familial calcium pyrophosphate deposition 9.9
369 rare hereditary hemochromatosis 9.9
370 bladder cancer 9.9
371 multiple sclerosis 9.9
372 macroglossia 9.9
373 neural tube defects 9.9
374 factor vii deficiency 9.9
375 hepatitis c virus 9.9
376 crohn's colitis 9.9
377 myelomeningocele 9.9
378 chronic meningitis 9.9
379 olecranon bursitis 9.9
380 locked-in syndrome 9.9
381 renal osteodystrophy 9.9
382 iritis 9.9
383 hepatitis c 9.9
384 hidradenitis suppurativa 9.9
385 hidradenitis 9.9
386 relapsing polychondritis 9.9
387 aortic valve insufficiency 9.9
388 conjunctivitis 9.9
389 adenoma 9.9
390 tertiary syphilis 9.9
391 cataract 9.9
392 cholangitis 9.9
393 al amyloidosis 9.9
394 amyloidosis aa 9.9
395 human t-cell leukemia virus type 1 9.9
396 fibroblastic rheumatism 9.9
397 ovarian cancer 9.9
398 albinism, oculocutaneous, type ii 9.9
399 ataxia-telangiectasia 9.9
400 moyamoya disease 1 9.9
401 leukemia, acute myeloid 9.9
402 paragangliomas 3 9.9
403 kala-azar 1 9.9
404 west nile virus 9.9
405 major affective disorder 8 9.9
406 major affective disorder 9 9.9
407 hermansky-pudlak syndrome 5 9.9
408 myelodysplastic syndrome 9.9
409 tick-borne encephalitis 9.9
410 oculocutaneous albinism 9.9
411 cortical blindness 9.9
412 dengue hemorrhagic fever 9.9
413 male infertility 9.9
414 azoospermia 9.9
415 food allergy 9.9
416 vaccinia 9.9
417 bipolar disorder 9.9
418 leishmaniasis 9.9
419 follicular mucinosis 9.9
420 albinism 9.9
421 brain injury 9.9
422 alcohol dependence 9.9
423 gastroesophageal reflux 9.9
424 colorectal cancer 9.9
425 diabetes mellitus, noninsulin-dependent 9.9
426 fibrosis of extraocular muscles, congenital, 1 9.9
427 marfan syndrome 9.9
428 neurofibromatosis, type iv, of riccardi 9.9
429 patella, chondromalacia of 9.9
430 spondylosis, cervical 9.9
431 varicose veins 9.9
432 arterial tortuosity syndrome 9.9
433 osteoid osteoma 9.9
434 intervertebral disc disease 9.9
435 allergic rhinitis 9.9
436 seizures, scoliosis, and macrocephaly/microcephaly syndrome 9.9
437 turnpenny-fry syndrome 9.9
438 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
439 tendinosis 9.9
440 vitamin k deficiency bleeding 9.9
441 dementia 9.9
442 epicondylitis 9.9
443 generalized anxiety disorder 9.9
444 panniculitis 9.9
445 rheumatic fever 9.9
446 giant cell tumor 9.9
447 arteriosclerosis 9.9
448 sensory peripheral neuropathy 9.9
449 cellulitis 9.9
450 aortic aneurysm 9.9
451 ulnar neuropathy 9.9
452 movement disease 9.9
453 kidney disease 9.9
454 inherited metabolic disorder 9.9
455 compartment syndrome 9.9
456 peroneal nerve paralysis 9.9
457 hemarthrosis 9.9
458 muscular dystrophy 9.9
459 villonodular synovitis 9.9
460 anaplastic oligoastrocytoma 9.9
461 hemophilic arthropathy 9.9
462 spasticity 9.9
463 acute liver failure 9.9
464 polykaryocytosis inducer 9.8
465 root resorption 9.8
466 glossitis 9.8
467 lysosomal storage disease 9.8
468 croup 9.8
469 lysosomal storage disease with skeletal involvement 9.8
470 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.8
471 osteopoikilosis 9.8
472 diabetic polyneuropathy 9.8
473 achilles bursitis 9.8
474 estrogen excess 9.8
475 heel spur 9.8
476 bronchitis 9.8
477 phocomelia 9.8
478 temporomandibular ankylosis 9.8
479 atrial standstill 1 9.8
480 felty syndrome 9.8
481 hypophosphatasia, adult 9.8
482 myelopathy, htlv-1-associated 9.8
483 nephrolithiasis, calcium oxalate 9.8
484 spinal arachnoiditis 9.8
485 neuropathy, hereditary sensory and autonomic, type iia 9.8
486 diabetes mellitus, insulin-dependent 9.8
487 hydatidiform mole, recurrent, 1 9.8
488 fabry disease 9.8
489 pulmonary hypertension 9.8
490 rheumatic heart disease 9.8
491 ectopic pregnancy 9.8
492 mumps 9.8
493 endometriosis of ovary 9.8
494 arachnoiditis 9.8
495 goiter 9.8
496 ulceration of vulva 9.8
497 urethritis 9.8
498 toxic shock syndrome 9.8
499 alcoholic neuropathy 9.8
500 shoulder impingement syndrome 9.8
501 viral hepatitis 9.8
502 gaucher's disease 9.8
503 hepatitis b 9.8
504 hepatitis 9.8
505 granulomatous hepatitis 9.8
506 gastroenteritis 9.8
507 agammaglobulinemia 9.8
508 acrodermatitis 9.8
509 hemoglobinopathy 9.8
510 endometriosis 9.8
511 interstitial lung disease 9.8
512 tropical spastic paraparesis 9.8
513 myelitis 9.8
514 tracheal stenosis 9.8
515 purpura 9.8
516 gestational trophoblastic neoplasm 9.8
517 plexopathy 9.8
518 pyoderma 9.8
519 folliculitis 9.8
520 pyoderma gangrenosum 9.8
521 measles 9.8
522 erythema infectiosum 9.8
523 macroglobulinemia 9.8
524 interstitial keratitis 9.8
525 alopecia 9.8
526 keloid disorder 9.8
527 amyloid neuropathy 9.8
528 cutaneous polyarteritis nodosa 9.8
529 gigantism 9.8
530 htlv-1 associated myelopathy/tropical spastic paraparesis 9.8
531 pustular psoriasis 9.8
532 scleromyxedema 9.8
533 encephalopathy 9.8
534 syringohydromyelia 9.8
535 rare surgical neurologic disease 9.8
536 pasteurella multocida infection 9.8
537 alzheimer disease 9.8
538 dupuytren contracture 9.8
539 hair whorl 9.8
540 hashimoto thyroiditis 9.8
541 retinoblastoma 9.8
542 slipped femoral capital epiphyses 9.8
543 temporal arteritis 9.8
544 thumb deformity 9.8
545 hutterite cerebroosteonephrodysplasia syndrome 9.8
546 familial mediterranean fever 9.8
547 sarcoma, synovial 9.8
548 hypophosphatemic rickets, x-linked dominant 9.8
549 retinitis pigmentosa 11 9.8
550 helicobacter pylori infection 9.8
551 asthma 9.8
552 yemenite deaf-blind hypopigmentation syndrome 9.8
553 macular degeneration, age-related, 1 9.8
554 homocysteinemia 9.8
555 sickle cell anemia 9.8
556 chudley-mccullough syndrome 9.8
557 major depressive disorder 9.8
558 human immunodeficiency virus type 1 9.8
559 lung cancer susceptibility 3 9.8
560 leukemia, acute lymphoblastic 9.8
561 microcephaly, epilepsy, and diabetes syndrome 9.8
562 graft-versus-host disease 9.8
563 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.8
564 peripheral vascular disease 9.8
565 chlamydia pneumonia 9.8
566 inguinal hernia 9.8
567 lymphocytic leukemia 9.8
568 bacterial infectious disease 9.8
569 hemiplegia 9.8
570 prostatic hypertrophy 9.8
571 hypoparathyroidism 9.8
572 chlamydia 9.8
573 multicentric reticulohistiocytosis 9.8
574 myopia 9.8
575 neutropenia 9.8
576 cardiovascular system disease 9.8
577 vertebrobasilar insufficiency 9.8
578 sapho syndrome 9.8
579 squamous cell papilloma 9.8
580 patellofemoral pain syndrome 9.8
581 blount's disease 9.8
582 disease of mental health 9.8
583 cystitis 9.8
584 neuritis 9.8
585 calcinosis 9.8
586 neuroma 9.8
587 post-traumatic stress disorder 9.8
588 opiate dependence 9.8
589 papilloma 9.8
590 dermatitis 9.8
591 bruxism 9.8
592 pulmonary tuberculosis 9.8
593 ischemia 9.8
594 teratoma 9.8
595 myofascial pain syndrome 9.8
596 rhinitis 9.8
597 familial retinoblastoma 9.8
598 poliomyelitis 9.8
599 liver cirrhosis 9.8
600 acute stress disorder 9.8
601 thyroiditis 9.8
602 chronic kidney disease 9.8
603 lung disease 9.8
604 ulcerative colitis 9.8
605 subacute delirium 9.8
606 vascular dementia 9.8
607 intermediate coronary syndrome 9.8
608 meningitis 9.8
609 encephalitis 9.8
610 neurofibroma 9.8
611 irritable bowel syndrome 9.8
612 heritable thoracic aortic disease 9.8
613 congenital dislocation of the patella 9.8
614 mycobacterium xenopi 9.8
615 prosthetic joint infection 9.8
616 whiplash 9.8
617 perioral myoclonia with absences 9.8
618 benign idiopathic neonatal seizures 9.8
619 lymphedema 9.8
620 glioma 9.8 MEG3 HOTAIR H19 GAS5
621 kidney cancer 9.7 MEG3 HOTAIR H19 GAS5
622 annular erythema 9.6
623 cardiomyopathy, dilated, 1a 9.6
624 charcot-marie-tooth disease, demyelinating, type 1a 9.6
625 chiari malformation type i 9.6
626 familial cold autoinflammatory syndrome 1 9.6
627 fibrodysplasia ossificans progressiva 9.6
628 hemangioma-thrombocytopenia syndrome 9.6
629 hyperparathyroidism 1 9.6
630 ige responsiveness, atopic 9.6
631 keloid formation 9.6
632 keratitis-ichthyosis-deafness syndrome, autosomal dominant 9.6
633 lipodystrophy, familial partial, type 2 9.6
634 antigen defined by monoclonal antibody aj9 9.6
635 antigen defined by monoclonal antibody t87 9.6
636 hyperuricemic nephropathy, familial juvenile, 1 9.6
637 neurofibromatosis, type i 9.6
638 thiemann disease 9.6
639 pheochromocytoma 9.6
640 pityriasis rubra pilaris 9.6
641 schizophrenia 9.6
642 spondyloarthropathy 2 9.6
643 muckle-wells syndrome 9.6
644 afibrinogenemia, congenital 9.6
645 neuropathy, hereditary sensory and autonomic, type iii 9.6
646 enterocolitis 9.6
647 eosinophilic fasciitis 9.6
648 fibrosclerosis, multifocal 9.6
649 lymphoma, hodgkin, classic 9.6
650 jejunal atresia 9.6
651 mycosis fungoides 9.6
652 insensitivity to pain, congenital, with anhidrosis 9.6
653 chronic recurrent multifocal osteomyelitis 9.6
654 scott syndrome 9.6
655 pyle disease 9.6
656 restrictive dermopathy, lethal 9.6
657 adrenomyodystrophy 9.6
658 chromosome xq26.3 duplication syndrome 9.6
659 aarskog-scott syndrome 9.6
660 lowe oculocerebrorenal syndrome 9.6
661 ataxia and polyneuropathy, adult-onset 9.6
662 short tarsus with absence of lower eyelashes 9.6
663 lymphoma, non-hodgkin, familial 9.6
664 pars planitis 9.6
665 scheie syndrome 9.6
666 psoriasis 9 9.6
667 neuropathy, hereditary sensory and autonomic, type v 9.6
668 hyperparathyroidism 3 9.6
669 intraocular pressure quantitative trait locus 9.6
670 chondrosarcoma, extraskeletal myxoid 9.6
671 factor xi deficiency 9.6
672 microvascular complications of diabetes 3 9.6
673 microvascular complications of diabetes 4 9.6
674 microvascular complications of diabetes 6 9.6
675 microvascular complications of diabetes 7 9.6
676 aicardi-goutieres syndrome 5 9.6
677 alpha-1-antitrypsin deficiency 9.6
678 prothrombin deficiency, congenital 9.6
679 cholangitis, primary sclerosing 9.6
680 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.6
681 alacrima, achalasia, and mental retardation syndrome 9.6
682 brown syndrome 9.6
683 warburg-cinotti syndrome 9.6
684 juvenile ankylosing spondylitis 9.6
685 erythema multiforme 9.6
686 familial adenomatous polyposis 9.6
687 hyperphosphatemia 9.6
688 aicardi-goutieres syndrome 9.6
689 diffuse large b-cell lymphoma 9.6
690 marginal zone b-cell lymphoma 9.6
691 t-cell large granular lymphocyte leukemia 9.6
692 paramyloidosis 9.6
693 fibroma 9.6
694 adrenal gland pheochromocytoma 9.6
695 inflammatory myofibroblastic tumor 9.6
696 immunoglobulin alpha deficiency 9.6
697 lymphoma 9.6
698 heavy chain disease 9.6
699 ischemic colitis 9.6
700 collagenous colitis 9.6
701 basal ganglia calcification 9.6
702 breast abscess 9.6
703 acrodermatitis chronica atrophicans 9.6
704 lymphoproliferative syndrome 9.6
705 salmonellosis 9.6
706 malignant pheochromocytoma 9.6
707 familial cold autoinflammatory syndrome 9.6
708 cholelithiasis 9.6
709 siderosis 9.6
710 dressler's syndrome 9.6
711 meningoencephalitis 9.6
712 charcot-marie-tooth disease 9.6
713 tropical sprue 9.6
714 protein-losing enteropathy 9.6
715 cystinosis 9.6
716 mastitis 9.6
717 renal hypertension 9.6
718 portal hypertension 9.6
719 filariasis 9.6
720 malignant hypertension 9.6
721 microcephaly 9.6
722 tooth disease 9.6
723 discitis 9.6
724 sarcoma 9.6
725 anhidrosis 9.6
726 respiratory failure 9.6
727 primary hyperparathyroidism 9.6
728 arteriovenous malformation 9.6
729 constrictive pericarditis 9.6
730 suppurative otitis media 9.6
731 emery-dreifuss muscular dystrophy 9.6
732 visual epilepsy 9.6
733 nephrotic syndrome 9.6
734 ischemic neuropathy 9.6
735 synostosis 9.6
736 ulnar nerve lesion 9.6
737 dengue disease 9.6
738 alcoholic hepatitis 9.6
739 bronchopneumonia 9.6
740 secondary hyperparathyroidism of renal origin 9.6
741 hepatitis a 9.6
742 posterior uveitis 9.6
743 nephrocalcinosis 9.6
744 nephronophthisis 9.6
745 telangiectasis 9.6
746 mikulicz disease 9.6
747 balanitis 9.6
748 megaloblastic anemia 9.6
749 scleritis 9.6
750 loiasis 9.6
751 cholestasis 9.6
752 phaeohyphomycosis 9.6
753 bicipital tenosynovitis 9.6
754 adult dermatomyositis 9.6
755 childhood type dermatomyositis 9.6
756 chronic purulent otitis media 9.6
757 adult-onset still's disease 9.6
758 sclerosing cholangitis 9.6
759 pyuria 9.6
760 neuronal ceroid lipofuscinosis 9.6
761 prostatitis 9.6
762 nodular nonsuppurative panniculitis 9.6
763 diffuse scleroderma 9.6
764 keratosis 9.6
765 ventricular septal defect 9.6
766 heart septal defect 9.6
767 ichthyosis 9.6
768 cheilitis 9.6
769 hypogonadism 9.6
770 autoimmune hepatitis 9.6
771 factor xiii deficiency 9.6
772 prothrombin deficiency 9.6
773 iron metabolism disease 9.6
774 benign mesothelioma 9.6
775 idiopathic interstitial pneumonia 9.6
776 cryoglobulinemia 9.6
777 membranoproliferative glomerulonephritis 9.6
778 cystic kidney disease 9.6
779 primary hyperoxaluria 9.6
780 glioblastoma multiforme 9.6
781 gingival overgrowth 9.6
782 rhabdomyosarcoma 9.6
783 central nervous system disease 9.6
784 palmoplantar keratosis 9.6
785 plague 9.6
786 lactic acidosis 9.6
787 pulmonary fibrosis 9.6
788 granuloma annulare 9.6
789 hepatic tuberculosis 9.6
790 spindle cell sarcoma 9.6
791 polyradiculoneuropathy 9.6
792 erdheim-chester disease 9.6
793 extraosseous chondrosarcoma 9.6
794 subacute bacterial endocarditis 9.6
795 vasomotor rhinitis 9.6
796 benign ependymoma 9.6
797 thyroid gland disease 9.6
798 nutritional deficiency disease 9.6
799 chronic inflammatory demyelinating polyradiculoneuropathy 9.6
800 infertility 9.6
801 cellular ependymoma 9.6
802 median neuropathy 9.6
803 nerve compression syndrome 9.6
804 myxoid chondrosarcoma 9.6
805 double outlet right ventricle 9.6
806 bone lymphoma 9.6
807 monoclonal gammopathy of uncertain significance 9.6
808 hypogonadotropism 9.6
809 malignant pleural mesothelioma 9.6
810 osgood-schlatter's disease 9.6
811 placenta disease 9.6
812 myocarditis 9.6
813 peritonitis 9.6
814 sezary's disease 9.6
815 nervous system disease 9.6
816 pyomyositis 9.6
817 parapsoriasis 9.6
818 orbital plasma cell granuloma 9.6
819 intracranial hypertension 9.6
820 hypersensitivity vasculitis 9.6
821 toxoplasmosis 9.6
822 tertiary neurosyphilis 9.6
823 hypereosinophilic syndrome 9.6
824 juvenile hereditary hemochromatosis 9.6
825 trpv4-associated disorders 9.6
826 acute non lymphoblastic leukemia 9.6
827 antisynthetase syndrome 9.6
828 borrone di rocco crovato syndrome 9.6
829 chromosome 5q duplication 9.6
830 cold urticaria 9.6
831 congenital rubella 9.6
832 fibromatosis 9.6
833 granulocytopenia 9.6
834 hemangioendothelioma 9.6
835 light chain deposition disease 9.6
836 metatarsus adductus 9.6
837 mollaret meningitis 9.6
838 mycobacterium avium complex infections 9.6
839 papular mucinosis 9.6
840 perniosis 9.6
841 pituitary stalk interruption syndrome 9.6
842 polyarticular onset juvenile idiopathic arthritis 9.6
843 pure autonomic failure 9.6
844 remitting seronegative symmetrical synovitis with pitting edema 9.6
845 retroperitoneal fibrosis 9.6
846 singleton-merten syndrome 9.6
847 soft tissue sarcoma 9.6
848 wells syndrome 9.6
849 dysautonomia 9.6
850 fainting 9.6
851 hypertonia 9.6
852 mucopolysaccharidoses 9.6
853 pituitary tumors 9.6
854 seizure disorder 9.6
855 rare systemic disease 9.6
856 epithelioid hemangioendothelioma 9.6
857 pulmonary arterial hypertension associated with portal hypertension 9.6
858 rare vascular tumor 9.6
859 isolated agammaglobulinemia 9.6
860 allopurinol toxicity 9.6
861 primary bone lymphoma 9.6
862 disorder of tyrosine metabolism 9.6
863 polyarticular juvenile idiopathic arthritis 9.6
864 polymerase proofreading-related adenomatous polyposis 9.6
865 epidermal disease 9.6
866 undetermined colitis 9.6
867 aortic aneurysm, familial abdominal, 1 9.6
868 pfeiffer syndrome 9.6
869 hajdu-cheney syndrome 9.6
870 amyloidosis, hereditary, transthyretin-related 9.6
871 apnea, obstructive sleep 9.6
872 behcet syndrome 9.6
873 hepatocellular carcinoma 9.6
874 cleft palate, isolated 9.6
875 coloboma of macula 9.6
876 corneal dystrophy, epithelial basement membrane 9.6
877 crouzon syndrome 9.6
878 ehlers-danlos syndrome, periodontal type, 1 9.6
879 camurati-engelmann disease 9.6
880 factor viii deficiency 9.6
881 fingers, relative length of 9.6
882 hypertelorism 9.6
883 hypertension, essential 9.6
884 hypertriglyceridemia, familial 9.6
885 kaposi sarcoma 9.6
886 leiomyoma, uterine 9.6
887 motion sickness 9.6
888 myositis 9.6
889 nail-patella syndrome 9.6
890 otitis media 9.6
891 paroxysmal extreme pain disorder 9.6
892 papillomatosis, confluent and reticulated 9.6
893 parkinson disease, late-onset 9.6
894 greig cephalopolysyndactyly syndrome 9.6
895 hutchinson-gilford progeria syndrome 9.6
896 prostate cancer 9.6
897 dowling-degos disease 1 9.6
898 retinal detachment 9.6
899 scheuermann disease 9.6
900 schistosoma mansoni infection, susceptibility/ 9.6
901 small cell cancer of the lung 9.6
902 strabismus 9.6
903 tarsal coalition 9.6
904 digeorge syndrome 9.6
905 down syndrome 9.6
906 abetalipoproteinemia 9.6
907 anemia, autoimmune hemolytic 9.6
908 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 9.6
909 bardet-biedl syndrome 1 9.6
910 lung cancer 9.6
911 hypoascorbemia 9.6
912 immune deficiency disease 9.6
913 leprosy 3 9.6
914 pancreatic cancer 9.6
915 pierre robin syndrome 9.6
916 wilson disease 9.6
917 uruguay faciocardiomusculoskeletal syndrome 9.6
918 hypophosphatemic rickets, x-linked recessive 9.6
919 mend syndrome 9.6
920 alpha-thalassemia/mental retardation syndrome, x-linked 9.6
921 hemophilia a 9.6
922 taqi polymorphism 9.6
923 prostatic hyperplasia, benign 9.6
924 craniosynostosis, adelaide type 9.6
925 cd4/cd8 t-cell ratio 9.6
926 hypocalcemia, autosomal dominant 1 9.6
927 amelia, posterior, with pelvic and pulmonary hypoplasia syndrome 9.6
928 stroke, ischemic 9.6
929 trichothiodystrophy 1, photosensitive 9.6
930 branchiootic syndrome 1 9.6
931 dermatitis, atopic 9.6
932 polydactyly 9.6
933 microvascular complications of diabetes 1 9.6
934 orthostatic intolerance 9.6
935 abdominal obesity-metabolic syndrome 1 9.6
936 late-onset retinal degeneration 9.6
937 alveolar soft part sarcoma 9.6
938 aortic aneurysm, familial thoracic 1 9.6
939 resting heart rate, variation in 9.6
940 epidermolysis bullosa simplex superficialis 9.6
941 hypertensive nephropathy 9.6
942 spondyloepiphyseal dysplasia, kimberley type 9.6
943 mevalonic aciduria 9.6
944 stature quantitative trait locus 14 9.6
945 microvascular complications of diabetes 2 9.6
946 microvascular complications of diabetes 5 9.6
947 fatty liver disease, nonalcoholic 1 9.6
948 plasminogen activator inhibitor-1 deficiency 9.6
949 mseleni joint disease 9.6
950 gastric cancer 9.6
951 nail disorder, nonsyndromic congenital, 10 9.6
952 myopathy, distal, tateyama type 9.6
953 dengue virus 9.6
954 cerebellar ataxia, neuropathy, and vestibular areflexia syndrome 9.6
955 kosaki overgrowth syndrome 9.6
956 chorea, childhood-onset, with psychomotor retardation 9.6
957 mucopolysaccharidosis-plus syndrome 9.6
958 chronic ulcer of skin 9.6
959 deficiency anemia 9.6
960 chikungunya 9.6
961 ross river fever 9.6
962 inflammatory bowel disease 9.6
963 arterial calcification of infancy 9.6
964 metabolic acidosis 9.6
965 secondary progressive multiple sclerosis 9.6
966 oromandibular dystonia 9.6
967 chronic venous insufficiency 9.6
968 ameloblastoma 9.6
969 bone chondrosarcoma 9.6
970 infective endocarditis 9.6
971 atrial fibrillation 9.6
972 gallbladder disease 9.6
973 pollen allergy 9.6
974 physical disorder 9.6
975 sensorineural hearing loss 9.6
976 corneal disease 9.6
977 venous insufficiency 9.6
978 dermatomyositis 9.6
979 aortic atherosclerosis 9.6
980 thalassemia 9.6
981 sialadenitis 9.6
982 tonsillitis 9.6
983 patellar tendinitis 9.6
984 lactose intolerance 9.6
985 japanese encephalitis 9.6
986 q fever 9.6
987 bartonellosis 9.6
988 hydronephrosis 9.6
989 pertussis 9.6
990 t cell deficiency 9.6
991 opioid abuse 9.6
992 cat-scratch disease 9.6
993 african histoplasmosis 9.6
994 tetanus 9.6
995 diphtheria 9.6
996 lyme disease 9.6
997 bronchial disease 9.6
998 clubfoot 9.6
999 esophagitis 9.6
1000 cryptococcosis 9.6
1001 aseptic meningitis 9.6
1002 plica syndrome 9.6
1003 spinal muscular atrophy 9.6
1004 secondary hyperparathyroidism 9.6
1005 pes anserinus tendinitis or bursitis 9.6
1006 von willebrand's disease 9.6
1007 acute leukemia 9.6
1008 leiomyoma 9.6
1009 quadriplegia 9.6
1010 guillain-barre syndrome 9.6
1011 choreatic disease 9.6
1012 keratoconjunctivitis sicca 9.6
1013 vertebral artery insufficiency 9.6
1014 paronychia 9.6
1015 uveitis 9.6
1016 familial hypercholesterolemia 9.6
1017 benign paroxysmal positional nystagmus 9.6
1018 interstitial cystitis 9.6
1019 schistosomiasis 9.6
1020 calcific tendinitis 9.6
1021 hypophosphatasia 9.6
1022 sporotrichosis 9.6
1023 type i ehlers-danlos syndrome 9.6
1024 avoidant personality disorder 9.6
1025 personality disorder 9.6
1026 urticaria 9.6
1027 chromoblastomycosis 9.6
1028 thrombocytopenia 9.6
1029 lymphadenitis 9.6
1030 skeletal tuberculosis 9.6
1031 chronic cystitis 9.6
1032 histoplasmosis 9.6
1033 pericarditis 9.6
1034 epilepsy 9.6
1035 dysostosis 9.6
1036 bardet-biedl syndrome 9.6
1037 hereditary multiple exostoses 9.6
1038 lateral sclerosis 9.6
1039 craniosynostosis 9.6
1040 glomus tumor 9.6
1041 glomangioma 9.6
1042 retinal vascular disease 9.6
1043 psychotic disorder 9.6
1044 reflex epilepsy 9.6
1045 hemangioma 9.6
1046 morphine dependence 9.6
1047 chondroma 9.6
1048 myoma 9.6
1049 pigmented villonodular synovitis 9.6
1050 tic disorder 9.6
1051 prostatic adenoma 9.6
1052 severe acute respiratory syndrome 9.6
1053 substance abuse 9.6
1054 acute kidney failure 9.6
1055 tenosynovial giant cell tumor 9.6
1056 scleredema adultorum 9.6
1057 lipomatosis 9.6
1058 mesenchymal cell neoplasm 9.6
1059 fibrosarcoma 9.6
1060 histiocytosis 9.6
1061 breast disease 9.6
1062 systemic mastocytosis 9.6
1063 turner syndrome 9.6
1064 mastocytosis 9.6
1065 plasmacytoma 9.6
1066 pleural empyema 9.6
1067 anterior compartment syndrome 9.6
1068 multidrug-resistant tuberculosis 9.6
1069 neuromuscular disease 9.6
1070 macular retinal edema 9.6
1071 hypokalemia 9.6
1072 uremia 9.6
1073 intracranial hypotension 9.6
1074 calciphylaxis 9.6
1075 somatoform disorder 9.6
1076 pancreatitis 9.6
1077 plexiform neurofibroma 9.6
1078 aortic disease 9.6
1079 human immunodeficiency virus infectious disease 9.6
1080 intestinal disease 9.6
1081 dystonia 9.6
1082 eye disease 9.6
1083 hemolytic anemia 9.6
1084 acquired immunodeficiency syndrome 9.6
1085 premenstrual tension 9.6
1086 diverticulitis 9.6
1087 stomach disease 9.6
1088 parathyroid adenoma 9.6
1089 neuroblastoma 9.6
1090 gastrointestinal system disease 9.6
1091 end stage renal failure 9.6
1092 hyperthyroidism 9.6
1093 synovial angioma 9.6
1094 localized scleroderma 9.6
1095 herpes zoster 9.6
1096 collagen disease 9.6
1097 herpes simplex 9.6
1098 chickenpox 9.6
1099 vein disease 9.6
1100 decubitus ulcer 9.6
1101 skin melanoma 9.6
1102 mechanical strabismus 9.6
1103 lymphangitis 9.6
1104 taylor's syndrome 9.6
1105 carotid artery dissection 9.6
1106 keratoconjunctivitis 9.6
1107 exophthalmos 9.6
1108 acute myocardial infarction 9.6
1109 miliary tuberculosis 9.6
1110 periostitis 9.6
1111 drug dependence 9.6
1112 hypoglycemia 9.6
1113 hereditary multiple osteochondromas 9.6
1114 hereditary transthyretin amyloidosis 9.6
1115 sost-related sclerosing bone dysplasias 9.6
1116 trichorhinophalangeal syndrome 9.6
1117 type ii collagen disorders 9.6
1118 acute articular rheumatism 9.6
1119 acute mountain sickness 9.6
1120 atlanto-axial fusion 9.6
1121 bone marrow necrosis 9.6
1122 congenital femoral deficiency 9.6
1123 fetal thalidomide syndrome 9.6
1124 growth hormone deficiency 9.6
1125 haemophilus influenzae 9.6
1126 hansen's disease 9.6
1127 heparin-induced thrombocytopenia 9.6
1128 lymphomatous thyroiditis 9.6
1129 mycobacterium chelonae 9.6
1130 pediatric acute-onset neuropsychiatric syndrome 9.6
1131 persistent genital arousal disorder 9.6
1132 piriformis syndrome 9.6
1133 polymyositis 9.6
1134 rheumatoid vasculitis 9.6
1135 cav3-related distal myopathy 9.6
1136 isolated pierre robin sequence 9.6
1137 anoxia 9.6
1138 autonomic dysfunction 9.6
1139 dysphagia 9.6
1140 foot drop 9.6
1141 headache 9.6
1142 hypotonia 9.6
1143 myoclonus 9.6
1144 paraneoplastic syndromes 9.6
1145 repetitive stress injuries 9.6
1146 syncope 9.6
1147 traumatic brain injury 9.6
1148 tremor 9.6
1149 systemic autoimmune disease 9.6
1150 cerebrofacial arteriovenous metameric syndrome 9.6
1151 hereditary mixed polyposis syndrome 9.6
1152 inflammatory myopathy with abundant macrophages 9.6
1153 temporomandibular joint anomaly 9.6
1154 elastofibroma dorsi 9.6
1155 acute sensory ataxic neuropathy 9.6
1156 wild type attr amyloidosis 9.6
1157 ciliopathy 9.6
1158 amelia 9.6
1159 combined pulmonary fibrosis-emphysema syndrome 9.6
1160 chronic enteropathy associated with slco2a1 gene 9.6
1161 spontaneous intracranial hypotension 9.6
1162 argyria 9.6
1163 serotonin syndrome 9.6
1164 solitary bone cyst 9.6
1165 primary bone dysplasia with increased bone density 9.6
1166 multiple epiphyseal dysplasia and pseudoachondroplasia 9.6
1167 thyroid carcinoma 9.6
1168 prostate disease 9.6 PCGEM1 MEG3 H19 GAS5

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (showing 23, show less)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Decubitus Ulcer
Deficiency Anemia Dysthymic Disorder
Esophagitis First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Iron Deficiency Anemia Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

Human phenotypes related to Osteoarthritis:

31 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 hip osteoarthritis 31 HP:0008843
2 abnormality of pelvic girdle bone morphology 31 HP:0002644

UMLS symptoms related to Osteoarthritis:


tremor, joint stiffness, arthralgia, angina pectoris, back pain, sciatica, equilibration disorder, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

Drugs & Therapeutics for Osteoarthritis

PubMed Health treatment related to Osteoarthritis: 62

There are many different suggestions and recommendations for treating osteoarthritis , but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible. There are two different types of therapies : Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy . The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle -strengthening exercises could help people with knee osteoarthritis . Other treatment options include massage , acupuncture , TENS, medicinal baths or orthopedic insoles. Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy ). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation . There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 641, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
7
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
8
Aceclofenac Approved, Investigational Phase 4 89796-99-6
9 Orange Approved Phase 4
10
Histamine Approved, Investigational Phase 4 51-45-6 774
11
Chlorzoxazone Approved Phase 4 95-25-0 2733
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
14
Zoledronic Acid Approved Phase 4 118072-93-8 68740
15
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
16
Zolpidem Approved Phase 4 82626-48-0 5732
17
Promethazine Approved, Investigational Phase 4 60-87-7 4927
18
Nabumetone Approved Phase 4 42924-53-8 4409
19
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
20
Piroxicam Approved, Investigational Phase 4 36322-90-4 5280452 54676228
21
Denosumab Approved Phase 4 615258-40-7
22
Enoxaparin Approved Phase 4 9005-49-6 772
23
Rivaroxaban Approved Phase 4 366789-02-8
24
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
25
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
26
Infliximab Approved Phase 4 170277-31-3
27
Prilocaine Approved Phase 4 721-50-6 4906
28
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
29
Dalteparin Approved Phase 4 9005-49-6
30
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
31
Zinc Approved, Investigational Phase 4 7440-66-6 32051
32
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
33
Hyoscyamine Approved Phase 4 101-31-5 64692
34
Parecoxib Approved Phase 4 198470-84-7
35
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
36
Ticagrelor Approved Phase 4 274693-27-5 9871419
37
Rutin Approved, Experimental, Investigational Phase 4 153-18-4 5280805
38
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
39
Etidronic acid Approved Phase 4 2809-21-4, 7414-83-7 3305
40
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
41
Demeclocycline Approved Phase 4 127-33-3 5311063