OA
MCID: OST012
MIFTS: 78

Osteoarthritis (OA)

Categories: Bone diseases, Muscle diseases

Aliases & Classifications for Osteoarthritis

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 12 74 25 29 54 6 42 3 15 37 62 39 17
Osteoarthrosis 12 25 15
Degenerative Joint Disease 12 25
Degenerative Polyarthritis 25 71
Hypertrophic Arthritis 12 25
Arthropathy 25 71
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 25
Osteoarthrosis Deformans 71
Arthritis, Degenerative 25
Degenerative Arthritis 12
Kashin-Beck Disease 71
Oa 25

Characteristics:


Classifications:



External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 34 715.3
SNOMED-CT via HPO 68 239872002 258211005 263681008
UMLS 71 C0022408 C0029408 C0086743 more

Summaries for Osteoarthritis

Genetics Home Reference : 25 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips. Osteoarthritis usually develops slowly, causing pain, stiffness, and restricted movement as the condition gets worse. Areas of bone no longer cushioned by cartilage rub against each other and start to break down. Further damage is caused as the body attempts to repair and rebuild these tissues. The immune system, which plays a role in healing injuries, targets these areas, and its response leads to inflammation of the joint tissues. Abnormal growths of bone (osteophytes) and other tissue can also occur, and may be visible as enlarged joints. Enlargement of the joints of the fingers is especially noticeable. People with osteoarthritis typically experience stiffness following periods of inactivity such as upon awakening or rising from a chair; the stiffness usually improves as they move around. In some affected individuals, the condition never causes major problems. In others, severe osteoarthritis can impair mobility and the ability to perform daily tasks, affecting quality of life and increasing the risk of other health conditions such as cardiovascular disease. Osteoarthritis is most common in middle age or late adulthood, because the cartilage at the joints naturally begins to thin as people age. However, it can occur earlier in life, especially after injuries affecting the joints such as a type of knee injury called an anterior cruciate ligament (ACL) tear. People who are overweight or whose activities are particularly stressful to the joints are also at increased risk of developing osteoarthritis.

MalaCards based summary : Osteoarthritis, also known as osteoarthrosis, is related to pseudoachondroplasia and diastrophic dysplasia, and has symptoms including joint stiffness, arthralgia and tremor. An important gene associated with Osteoarthritis is FRZB (Frizzled Related Protein), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotypes are abnormality of pelvic girdle bone morphology and hip osteoarthritis

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

MedlinePlus : 42 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint There is no specific test for osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or "wear and tear" arthritis. It occurs most frequently in the hands, hips, and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.

PubMed Health : 62 About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age. If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 74 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Related Diseases for Osteoarthritis

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 1181, show less)
# Related Disease Score Top Affiliating Genes
1 pseudoachondroplasia 33.4 MATN3 COMP COL2A1 ACAN
2 diastrophic dysplasia 33.2 MATN3 COMP COL2A1
3 cartilage disease 33.1 COMP COL2A1 ACAN
4 otospondylomegaepiphyseal dysplasia, autosomal recessive 33.0 COMP COL2A1
5 epiphyseal dysplasia, multiple, 2 32.8 MATN3 COMP
6 epiphyseal dysplasia, multiple, 1 32.7 MATN3 COMP
7 exostosis 32.5 GDF5 COL2A1 ACAN
8 epiphyseal dysplasia, multiple, 5 32.5 MATN3 COMP
9 synovitis 32.5 COMP COL2A1 ACAN
10 rheumatoid arthritis 32.4 HOTAIR H19 COMP COL2A1 CILP ACAN
11 arthropathy 32.2 COMP COL2A1 CILP ACAN
12 back pain 32.1 CILP ASPN
13 bone disease 31.4 MATN3 GDF5 COMP COL2A1 ACAN
14 osteochondritis dissecans 31.4 MATN3 COMP COL2A1 ACAN
15 spondyloepiphyseal dysplasia with congenital joint dislocations 31.3 COMP COL2A1 ACAN
16 chondromalacia 31.3 COMP ACAN
17 degenerative disc disease 31.3 GDF5 ASPN ACAN
18 multiple epiphyseal dysplasia 31.2 MATN3 COMP COL2A1 ACAN
19 spondylolisthesis 31.1 GDF5 ACAN
20 multiple epiphyseal dysplasia, autosomal dominant 31.1 MATN3 COMP
21 spondyloepiphyseal dysplasia congenita 31.0 MATN3 COMP COL2A1
22 bone inflammation disease 31.0 COMP COL2A1 ACAN
23 achondroplasia 30.9 COMP COL2A1 ACAN
24 brachydactyly 30.8 GDF5 COMP COL2A1 ACAN
25 skeletal dysplasias 30.8 MATN3 COMP COL2A1
26 osteochondrosis 30.8 COL2A1 ACAN
27 hypochondrogenesis 30.4 MATN3 COL2A1 ASPN ACAN
28 fibrochondrogenesis 30.4 GDF5 COL2A1 ACAN
29 spondyloepimetaphyseal dysplasia, matrilin-3 related 30.4 MATN3 COMP COL2A1 ACAN
30 odontochondrodysplasia 30.3 MATN3 GDF5 COMP COL2A1 ACAN
31 clubfoot 29.8 HOTAIR GDF5 COL2A1
32 pituitary adenoma 29.6 MEG3 HOTAIR H19
33 glioma susceptibility 1 29.4 MEG3 HOTAIR H19 GAS5
34 myeloma, multiple 28.7 MEG3 HOTAIR H19 GAS5
35 osteogenic sarcoma 28.6 PACERR MEG3 HOTAIR H19 GAS5 FRZB
36 malignant glioma 28.6 PCGEM1 MEG3 HOTAIR H19 GAS5
37 multicentric osteolysis, nodulosis, and arthropathy 12.8
38 arthropathy, progressive pseudorheumatoid, of childhood 12.7
39 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.7
40 osteoarthritis with mild chondrodysplasia 12.7
41 behcet's syndrome arthropathy 12.4
42 arthropathy, erosive 12.3
43 multicentric osteolysis-nodulosis-arthropathy spectrum 12.3
44 transient arthropathy 12.3
45 loeys-dietz syndrome 3 12.3
46 czech dysplasia 12.2
47 chondrocalcinosis 2 12.1
48 myhre syndrome 12.1
49 familial osteochondritis dissecans 12.1
50 esophageal atresia 11.9
51 chondrocalcinosis 1 11.8
52 beukes hip dysplasia 11.8
53 jaccoud's syndrome 11.7
54 mitochondrial dna depletion syndrome 6 11.7
55 microphthalmia with limb anomalies 11.6
56 anophthalmos with limb anomalies 11.6
57 hemochromatosis, type 2a 11.6
58 developmental dysplasia of the hip 1 11.6
59 spondylosis 11.5
60 arthritis 11.5
61 loeys-dietz syndrome 11.5
62 spondyloepiphyseal dysplasia tarda, x-linked 11.5
63 wild type abeta2m amyloidosis 11.5
64 winchester syndrome 11.5
65 cinca syndrome 11.4
66 fibromyalgia 11.4
67 mandibuloacral dysplasia with type a lipodystrophy 11.4
68 hemochromatosis type 2 11.4
69 primary hypertrophic osteoarthropathy 11.4
70 endosteal hyperostosis, autosomal dominant 11.4
71 legg-calve-perthes disease 11.4
72 alkaptonuria 11.4
73 ochronosis 11.4
74 hypophosphatemia 11.4
75 ehlers-danlos syndrome 11.4
76 congenital dislocation of the patella 11.4
77 occipital neuralgia 11.4
78 brachyolmia type 3 11.3
79 spondyloepiphyseal dysplasia, stanescu type 11.3
80 renal tubular acidosis, proximal, with ocular abnormalities and mental retardation 11.2
81 wolfram syndrome 11.2
82 otospondylomegaepiphyseal dysplasia, autosomal dominant 11.2
83 spondyloepimetaphyseal dysplasia with joint laxity, type 2 11.2
84 digital arthropathy-brachydactyly, familial 11.2
85 ehlers-danlos syndrome, classic-like, 2 11.2
86 mucopolysaccharidosis, type vi 11.1
87 cdags syndrome 11.1
88 marshall syndrome 11.1
89 atransferrinemia 11.1
90 d-lactic aciduria with gout 11.1
91 xanthinuria, type i 11.1
92 xanthinuria, type ii 11.1
93 hemochromatosis, type 2b 11.1
94 brachydactylous dwarfism mseleni type 11.1
95 plica syndrome 11.1
96 angel-shaped phalangoepiphyseal dysplasia 11.0
97 stickler syndrome, type i 11.0
98 kniest dysplasia 11.0
99 osteomesopyknosis 11.0
100 osteopetrosis, autosomal dominant 2 11.0
101 spondyloepiphyseal dysplasia tarda, autosomal dominant 11.0
102 spondylometaphyseal dysplasia, kozlowski type 11.0
103 desbuquois dysplasia 1 11.0
104 spondyloepimetaphyseal dysplasia, missouri type 11.0
105 stickler syndrome, type i, nonsyndromic ocular 11.0
106 developmental dysplasia of the hip 2 11.0
107 saul-wilson syndrome 11.0
108 ocular albinism 11.0
109 klippel-feil syndrome 11.0
110 central cord syndrome 11.0
111 chronic pain 10.9
112 osteoporosis 10.8
113 bone mineral density quantitative trait locus 8 10.8
114 bone mineral density quantitative trait locus 15 10.8
115 rapidly involuting congenital hemangioma 10.8
116 body mass index quantitative trait locus 1 10.7
117 acute tympanitis 10.7 MATN3 GDF5 ASPN
118 transient arthritis 10.7
119 platyspondylic lethal skeletal dysplasia, torrance type 10.7 MATN3 COMP COL2A1
120 achondrogenesis, type ii 10.7 MATN3 COMP COL2A1
121 achondrogenesis 10.7 MATN3 COMP COL2A1 ACAN
122 bone resorption disease 10.7
123 bone structure disease 10.7 GDF5 COL2A1 CILP ACAN
124 bone development disease 10.6 MATN3 GDF5 COMP COL2A1 ACAN
125 bone deterioration disease 10.6 GDF5 COL2A1 CILP ASPN ACAN
126 chondrodysplasia, grebe type 10.6 GDF5 COL2A1
127 enthesopathy 10.6
128 chondrocalcinosis 10.6
129 syringomyelia, noncommunicating isolated 10.6
130 syringomyelia 10.6
131 osteonecrosis 10.6
132 palindromic rheumatism 10.6
133 body mass index quantitative trait locus 11 10.6
134 epiphyseal dysplasia, multiple, 4 10.5 MATN3 COMP
135 body mass index quantitative trait locus 9 10.5
136 body mass index quantitative trait locus 8 10.5
137 body mass index quantitative trait locus 4 10.5
138 body mass index quantitative trait locus 10 10.5
139 body mass index quantitative trait locus 7 10.5
140 body mass index quantitative trait locus 12 10.5
141 body mass index quantitative trait locus 14 10.5
142 body mass index quantitative trait locus 18 10.5
143 body mass index quantitative trait locus 19 10.5
144 body mass index quantitative trait locus 20 10.5
145 psoriatic arthritis 10.5
146 gout 10.5
147 acromesomelic dysplasia 10.5 GDF5 COL2A1
148 aging 10.5
149 inflammatory spondylopathy 10.5
150 spondylitis 10.5
151 cytokine deficiency 10.5
152 spondyloarthropathy 1 10.5
153 kashin-beck disease 10.5
154 septic arthritis 10.5
155 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.4 MATN3 COMP
156 rickets 10.4
157 constipation 10.4
158 lipid metabolism disorder 10.4
159 frozen shoulder 10.4
160 bursitis 10.4
161 48,xyyy 10.4
162 chondrosarcoma 10.4
163 avascular necrosis 10.4
164 spondylometaphyseal dysplasia, sedaghatian type 10.4
165 pain agnosia 10.4
166 47,xyy 10.4
167 proteasome-associated autoinflammatory syndrome 1 10.4
168 ankylosis 10.4
169 pik3ca-related overgrowth syndrome 10.4
170 tabes dorsalis 10.4
171 osteomyelitis 10.3
172 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
173 tendinitis 10.3
174 tumoral calcinosis, hyperphosphatemic, familial, 1 10.3
175 intermittent hydrarthrosis 10.3
176 triiodothyronine receptor auxiliary protein 10.3
177 autosomal recessive disease 10.3
178 paraplegia 10.3
179 thrombophilia due to thrombin defect 10.3
180 spinal stenosis 10.3
181 exanthem 10.3
182 diabetes mellitus 10.3
183 vasculitis 10.3
184 autoimmune disease 10.3
185 sarcoidosis 1 10.3
186 cystic fibrosis 10.3
187 syphilis 10.3
188 tenosynovitis 10.3
189 b-cell lymphoma 10.2
190 allergic hypersensitivity disease 10.2
191 muscular atrophy 10.2
192 idiopathic avascular necrosis 10.2
193 hand skill, relative 10.2
194 insulin-like growth factor i 10.2
195 diarrhea 10.2
196 neuropathy 10.2
197 slipped capital femoral epiphysis 10.2
198 aneurysm 10.2
199 t-cell lymphoblastic leukemia/lymphoma 10.2
200 leukemia, t-cell, chronic 10.2
201 functionless pituitary adenoma 10.2 MEG3 HOTAIR
202 hypercholesterolemia, familial, 1 10.2
203 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
204 peptic ulcer disease 10.2
205 acrocallosal syndrome 10.2
206 anxiety 10.2
207 spondyloarthropathy 10.2
208 hyperostosis 10.2
209 atherosclerosis susceptibility 10.2
210 peripheral nervous system disease 10.2
211 reactive arthritis 10.2
212 active peptic ulcer disease 10.2
213 pulmonary embolism 10.2
214 bunion 10.2
215 hypoxia 10.2
216 paresthesia 10.2
217 crohn's disease 10.2
218 rubella 10.2
219 tumoral calcinosis, normophosphatemic, familial 10.2
220 familial tumoral calcinosis 10.2
221 popliteal cyst 10.2
222 hemochromatosis, type 1 10.2
223 sclerosteosis 10.2
224 hyperglycemia 10.2
225 sleep disorder 10.2
226 hypermobile ehlers-danlos syndrome 10.2
227 hemophilia b 10.1
228 pain sensitivity quantitative trait locus 1 10.1
229 autonomic neuropathy 10.1
230 carpal tunnel syndrome 10.1
231 tendinopathy 10.1
232 mammary paget's disease 10.1
233 gastritis 10.1
234 colitis 10.1
235 polyneuropathy 10.1
236 myopathy 10.1
237 esophagus squamous cell carcinoma 10.1 MEG3 HOTAIR
238 lipomatosis, multiple 10.1
239 coronary heart disease 1 10.1
240 pleomorphic lipoma 10.1
241 hyperuricemia 10.1
242 depression 10.1
243 overgrowth syndrome 10.1
244 systemic lupus erythematosus 10.1
245 muscle hypertrophy 10.1
246 scoliosis 10.1
247 acromegaly 10.1
248 congestive heart failure 10.1
249 dwarfism 10.1
250 factor viii deficiency 10.1
251 adult t-cell leukemia 10.1
252 chiari malformation 10.1
253 creatinine clearance quantitative trait locus 10.1
254 leptin deficiency or dysfunction 10.1
255 leech infestation 10.1
256 vascular disease 10.1
257 connective tissue disease 10.1
258 hereditary sensory neuropathy 10.1
259 asymptomatic neurosyphilis 10.1
260 neurosyphilis 10.1
261 myocardial infarction 10.0
262 leukemia, acute lymphoblastic 3 10.0
263 osteopetrosis 10.0
264 hypermobility syndrome 10.0
265 cerebral palsy 10.0
266 hyperinsulinism 10.0
267 complex regional pain syndrome 10.0
268 skin disease 10.0
269 spondylarthropathy 10.0
270 trochlear dysplasia 10.0
271 primary biliary cirrhosis 10.0
272 heart valve disease 10.0
273 thyroid cancer, nonmedullary, 1 10.0 MEG3 HOTAIR H19
274 gastric cardia adenocarcinoma 10.0 MEG3 HOTAIR H19
275 tick-borne encephalitis 10.0
276 non-alcoholic fatty liver disease 10.0
277 fatty liver disease 10.0
278 coxa vara 10.0
279 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 10.0
280 migraine with or without aura 1 10.0
281 reflex sympathetic dystrophy 10.0
282 bone mineral density quantitative trait locus 3 10.0
283 pulmonary disease, chronic obstructive 10.0
284 stickler syndrome 10.0
285 brucellosis 10.0
286 algoneurodystrophy 10.0
287 alcohol use disorder 10.0
288 mental depression 10.0
289 duodenal ulcer 10.0
290 liver disease 10.0
291 systemic scleroderma 10.0
292 radiculopathy 10.0
293 severe combined immunodeficiency 10.0
294 juvenile rheumatoid arthritis 10.0
295 psoriasis 10.0
296 fasciitis 10.0
297 plantar fasciitis 10.0
298 crystal arthropathies 10.0
299 synovial chondromatosis 10.0
300 premature aging 10.0
301 spondylolysis 10.0
302 celiac disease 1 10.0
303 sjogren syndrome 10.0
304 cauda equina syndrome 10.0
305 iridocyclitis 10.0
306 hypocomplementemic urticarial vasculitis 10.0
307 splenomegaly 10.0
308 raynaud phenomenon 10.0
309 proline-negative auxotroph of hamster, complementation of 10.0
310 arts syndrome 10.0
311 lipoprotein quantitative trait locus 10.0
312 angina pectoris 10.0
313 sleep apnea 10.0
314 spinal disease 10.0
315 heart disease 10.0
316 leukemia 10.0
317 acute cystitis 10.0
318 hypothyroidism 10.0
319 periarthritis 10.0
320 mood disorder 10.0
321 pustulosis of palm and sole 10.0
322 hydrarthrosis 10.0
323 periodontitis 10.0
324 amyloidosis 10.0
325 diabetic neuropathy 10.0
326 osteochondroma 10.0
327 spinal cord injury 10.0
328 acroosteolysis 9.9
329 keratitis, hereditary 9.9
330 chiari malformation type ii 9.9
331 beta-thalassemia 9.9
332 hemopericardium 9.9
333 pericardial effusion 9.9
334 dysentery 9.9
335 glomerulonephritis 9.9
336 mixed connective tissue disease 9.9
337 polyarteritis nodosa 9.9
338 spastic paraparesis 9.9
339 neurofibromatosis, type ii 9.9
340 arteries, anomalies of 9.9
341 fibrosis of extraocular muscles, congenital, 1 9.9
342 protrusio acetabuli 9.9
343 scleroderma, familial progressive 9.9
344 tuberous sclerosis 1 9.9
345 mycobacterium tuberculosis 1 9.9
346 avascular necrosis of femoral head, primary, 1 9.9
347 lung cancer susceptibility 3 9.9
348 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
349 seizures, scoliosis, and macrocephaly/microcephaly syndrome 9.9
350 hyperlipoproteinemia, type iii 9.9
351 helix syndrome 9.9
352 tendinosis 9.9
353 restless legs syndrome 9.9
354 peripheral artery disease 9.9
355 fibrous dysplasia 9.9
356 aortic dissection 9.9
357 endocarditis 9.9
358 nasopharyngitis 9.9
359 osteomalacia 9.9
360 glucose intolerance 9.9
361 gastric ulcer 9.9
362 hemosiderosis 9.9
363 tuberous sclerosis 9.9
364 hyperparathyroidism 9.9
365 epicondylitis 9.9
366 neurogenic arthropathy 9.9
367 transient cerebral ischemia 9.9
368 thrombophlebitis 9.9
369 paget's disease of bone 9.9
370 diffuse idiopathic skeletal hyperostosis 9.9
371 cerebrovascular disease 9.9
372 lupus erythematosus 9.9
373 hemophilia 9.9
374 sickle cell disease 9.9
375 chromosomal triplication 9.9
376 familial calcium pyrophosphate deposition 9.9
377 rare hereditary hemochromatosis 9.9
378 bladder cancer 9.9
379 multiple sclerosis 9.9
380 macroglossia 9.9
381 neural tube defects 9.9
382 factor vii deficiency 9.9
383 hepatitis c virus 9.9
384 crohn's colitis 9.9
385 myelomeningocele 9.9
386 chronic meningitis 9.9
387 olecranon bursitis 9.9
388 renal osteodystrophy 9.9
389 iritis 9.9
390 hepatitis c 9.9
391 hidradenitis suppurativa 9.9
392 hidradenitis 9.9
393 relapsing polychondritis 9.9
394 aortic valve insufficiency 9.9
395 nephrolithiasis 9.9
396 conjunctivitis 9.9
397 adenoma 9.9
398 tertiary syphilis 9.9
399 cataract 9.9
400 erythema infectiosum 9.9
401 cholangitis 9.9
402 al amyloidosis 9.9
403 amyloidosis aa 9.9
404 human t-cell leukemia virus type 1 9.9
405 fibroblastic rheumatism 9.9
406 ovarian cancer 9.9
407 albinism, oculocutaneous, type ii 9.9
408 ataxia-telangiectasia 9.9
409 moyamoya disease 1 9.9
410 leukemia, acute myeloid 9.9
411 paragangliomas 3 9.9
412 kala-azar 1 9.9
413 west nile virus 9.9
414 major affective disorder 8 9.9
415 major affective disorder 9 9.9
416 hermansky-pudlak syndrome 5 9.9
417 myelodysplastic syndrome 9.9
418 oculocutaneous albinism 9.9
419 cortical blindness 9.9
420 dengue hemorrhagic fever 9.9
421 male infertility 9.9
422 intermittent explosive disorder 9.9
423 azoospermia 9.9
424 food allergy 9.9
425 vaccinia 9.9
426 bipolar disorder 9.9
427 leishmaniasis 9.9
428 follicular mucinosis 9.9
429 albinism 9.9
430 alcohol dependence 9.9
431 gastroesophageal reflux 9.9
432 colorectal cancer 9.9
433 diabetes mellitus, noninsulin-dependent 9.9
434 hair whorl 9.9
435 marfan syndrome 9.9
436 patella, chondromalacia of 9.9
437 spondylosis, cervical 9.9
438 varicose veins 9.9
439 arterial tortuosity syndrome 9.9
440 osteoid osteoma 9.9
441 sarcoma, synovial 9.9
442 hypophosphatemic rickets, x-linked dominant 9.9
443 paine syndrome 9.9
444 retinitis pigmentosa 11 9.9
445 yemenite deaf-blind hypopigmentation syndrome 9.9
446 macular degeneration, age-related, 1 9.9
447 intervertebral disc disease 9.9
448 allergic rhinitis 9.9
449 hydrops, lactic acidosis, and sideroblastic anemia 9.9
450 turnpenny-fry syndrome 9.9
451 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
452 juvenile arthritis 9.9
453 thrombosis 9.9
454 covid-19 9.9
455 vitamin k deficiency bleeding 9.9
456 dementia 9.9
457 generalized anxiety disorder 9.9
458 panniculitis 9.9
459 rheumatic fever 9.9
460 arteriosclerosis 9.9
461 sensory peripheral neuropathy 9.9
462 opiate dependence 9.9
463 cellulitis 9.9
464 aortic aneurysm 9.9
465 myofascial pain syndrome 9.9
466 ulnar neuropathy 9.9
467 movement disease 9.9
468 kidney disease 9.9
469 inherited metabolic disorder 9.9
470 compartment syndrome 9.9
471 peroneal nerve paralysis 9.9
472 hemarthrosis 9.9
473 neurofibromatosis 9.9
474 muscular dystrophy 9.9
475 villonodular synovitis 9.9
476 anaplastic oligoastrocytoma 9.9
477 hemophilic arthropathy 9.9
478 spasticity 9.9
479 whiplash 9.9
480 acute liver failure 9.9
481 polykaryocytosis inducer 9.8
482 root resorption 9.8
483 glossitis 9.8
484 lysosomal storage disease 9.8
485 croup 9.8
486 lysosomal storage disease with skeletal involvement 9.8
487 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.8
488 osteopoikilosis 9.8
489 diabetic polyneuropathy 9.8
490 achilles bursitis 9.8
491 estrogen excess 9.8
492 heel spur 9.8
493 phocomelia 9.8
494 temporomandibular ankylosis 9.8
495 glioma 9.8 MEG3 HOTAIR H19 GAS5
496 atrial standstill 1 9.8
497 felty syndrome 9.8
498 hypophosphatasia, adult 9.8
499 myelopathy, htlv-1-associated 9.8
500 spinal arachnoiditis 9.8
501 neuropathy, hereditary sensory and autonomic, type iia 9.8
502 diabetes mellitus, type i 9.8
503 hydatidiform mole, recurrent, 1 9.8
504 fabry disease 9.8
505 scheie syndrome 9.8
506 pulmonary hypertension 9.8
507 rheumatic heart disease 9.8
508 lymphoma 9.8
509 ectopic pregnancy 9.8
510 mumps 9.8
511 endometriosis of ovary 9.8
512 arachnoiditis 9.8
513 goiter 9.8
514 ulceration of vulva 9.8
515 urethritis 9.8
516 toxic shock syndrome 9.8
517 alcoholic neuropathy 9.8
518 shoulder impingement syndrome 9.8
519 viral hepatitis 9.8
520 gaucher's disease 9.8
521 hepatitis b 9.8
522 hepatitis 9.8
523 granulomatous hepatitis 9.8
524 gastroenteritis 9.8
525 agammaglobulinemia 9.8
526 acrodermatitis 9.8
527 hemoglobinopathy 9.8
528 endometriosis 9.8
529 interstitial lung disease 9.8
530 tropical spastic paraparesis 9.8
531 myelitis 9.8
532 tracheal stenosis 9.8
533 purpura 9.8
534 gestational trophoblastic neoplasm 9.8
535 plexopathy 9.8
536 pyoderma 9.8
537 folliculitis 9.8
538 pyoderma gangrenosum 9.8
539 measles 9.8
540 macroglobulinemia 9.8
541 interstitial keratitis 9.8
542 alopecia 9.8
543 keloid disorder 9.8
544 amyloid neuropathy 9.8
545 cutaneous polyarteritis nodosa 9.8
546 gigantism 9.8
547 htlv-1 associated myelopathy/tropical spastic paraparesis 9.8
548 pustular psoriasis 9.8
549 scleromyxedema 9.8
550 dysautonomia 9.8
551 encephalopathy 9.8
552 syringohydromyelia 9.8
553 pasteurella multocida infection 9.8
554 alzheimer disease 9.8
555 dupuytren contracture 9.8
556 hashimoto thyroiditis 9.8
557 retinoblastoma 9.8
558 slipped femoral capital epiphyses 9.8
559 temporal arteritis 9.8
560 thumb deformity 9.8
561 hutterite cerebroosteonephrodysplasia syndrome 9.8
562 familial mediterranean fever 9.8
563 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 9.8
564 helicobacter pylori infection 9.8
565 asthma 9.8
566 homocysteinemia 9.8
567 brittle bone disorder 9.8
568 sickle cell anemia 9.8
569 chudley-mccullough syndrome 9.8
570 major depressive disorder 9.8
571 human immunodeficiency virus type 1 9.8
572 leukemia, acute lymphoblastic 9.8
573 microcephaly, epilepsy, and diabetes syndrome 9.8
574 graft-versus-host disease 9.8
575 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.8
576 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.8
577 joint laxity, short stature, and myopia 9.8
578 peripheral vascular disease 9.8
579 deficiency anemia 9.8
580 chlamydia pneumonia 9.8
581 infective endocarditis 9.8
582 inguinal hernia 9.8
583 hereditary lymphedema i 9.8
584 venous insufficiency 9.8
585 bacterial infectious disease 9.8
586 hemiplegia 9.8
587 prostatic hypertrophy 9.8
588 hypoparathyroidism 9.8
589 chlamydia 9.8
590 multicentric reticulohistiocytosis 9.8
591 myopia 9.8
592 neutropenia 9.8
593 cardiovascular system disease 9.8
594 vertebrobasilar insufficiency 9.8
595 sapho syndrome 9.8
596 squamous cell papilloma 9.8
597 patellofemoral pain syndrome 9.8
598 disease of mental health 9.8
599 cystitis 9.8
600 neuritis 9.8
601 calcinosis 9.8
602 benign giant cell tumor 9.8
603 neuroma 9.8
604 post-traumatic stress disorder 9.8
605 papilloma 9.8
606 dermatitis 9.8
607 bruxism 9.8
608 pulmonary tuberculosis 9.8
609 ischemia 9.8
610 teratoma 9.8
611 rhinitis 9.8
612 familial retinoblastoma 9.8
613 poliomyelitis 9.8
614 liver cirrhosis 9.8
615 acute stress disorder 9.8
616 thyroiditis 9.8
617 gastrointestinal system disease 9.8
618 chronic kidney disease 9.8
619 lung disease 9.8
620 ulcerative colitis 9.8
621 subacute delirium 9.8
622 vascular dementia 9.8
623 intermediate coronary syndrome 9.8
624 meningitis 9.8
625 encephalitis 9.8
626 neurofibroma 9.8
627 irritable bowel syndrome 9.8
628 heritable thoracic aortic disease 9.8
629 atlanto-axial fusion 9.8
630 mycobacterium xenopi 9.8
631 prosthetic joint infection 9.8
632 traumatic brain injury 9.8
633 perioral myoclonia with absences 9.8
634 benign idiopathic neonatal seizures 9.8
635 kidney cancer 9.7 MEG3 HOTAIR H19 GAS5
636 prostate disease 9.7 PCGEM1 MEG3 H19 GAS5
637 annular erythema 9.6
638 cardiomyopathy, dilated, 1a 9.6
639 charcot-marie-tooth disease, demyelinating, type 1a 9.6
640 chiari malformation type i 9.6
641 familial cold autoinflammatory syndrome 1 9.6
642 fibrodysplasia ossificans progressiva 9.6
643 hemangioma-thrombocytopenia syndrome 9.6
644 hyperparathyroidism 1 9.6
645 ige responsiveness, atopic 9.6
646 keloid formation 9.6
647 keratitis-ichthyosis-deafness syndrome, autosomal dominant 9.6
648 lipodystrophy, familial partial, type 2 9.6
649 antigen defined by monoclonal antibody aj9 9.6
650 antigen defined by monoclonal antibody t87 9.6
651 hyperuricemic nephropathy, familial juvenile, 1 9.6
652 neurofibromatosis, type i 9.6
653 thiemann disease 9.6
654 nephrolithiasis, calcium oxalate 9.6
655 pheochromocytoma 9.6
656 pityriasis rubra pilaris 9.6
657 schizophrenia 9.6
658 spondyloarthropathy 2 9.6
659 muckle-wells syndrome 9.6
660 afibrinogenemia, congenital 9.6
661 neuropathy, hereditary sensory and autonomic, type iii 9.6
662 enterocolitis 9.6
663 eosinophilic fasciitis 9.6
664 fibrosclerosis, multifocal 9.6
665 lymphoma, hodgkin, classic 9.6
666 jejunal atresia 9.6
667 mycosis fungoides 9.6
668 chronic recurrent multifocal osteomyelitis 9.6
669 scott syndrome 9.6
670 restrictive dermopathy, lethal 9.6
671 adrenomyodystrophy 9.6
672 chromosome xq26.3 duplication syndrome 9.6
673 aarskog-scott syndrome 9.6
674 lowe oculocerebrorenal syndrome 9.6
675 ataxia and polyneuropathy, adult-onset 9.6
676 short tarsus with absence of lower eyelashes 9.6
677 poikiloderma with neutropenia 9.6
678 lymphoma, non-hodgkin, familial 9.6
679 pars planitis 9.6
680 psoriasis 9 9.6
681 neuropathy, hereditary sensory and autonomic, type v 9.6
682 hyperparathyroidism 3 9.6
683 intraocular pressure quantitative trait locus 9.6
684 chondrosarcoma, extraskeletal myxoid 9.6
685 factor xi deficiency 9.6
686 microvascular complications of diabetes 3 9.6
687 microvascular complications of diabetes 4 9.6
688 microvascular complications of diabetes 6 9.6
689 microvascular complications of diabetes 7 9.6
690 aicardi-goutieres syndrome 5 9.6
691 alpha-1-antitrypsin deficiency 9.6
692 prothrombin deficiency, congenital 9.6
693 cholangitis, primary sclerosing 9.6
694 alacrima, achalasia, and mental retardation syndrome 9.6
695 brown syndrome 9.6
696 warburg-cinotti syndrome 9.6
697 juvenile ankylosing spondylitis 9.6
698 erythema multiforme 9.6
699 familial adenomatous polyposis 9.6
700 hyperphosphatemia 9.6
701 aicardi-goutieres syndrome 9.6
702 diffuse large b-cell lymphoma 9.6
703 marginal zone b-cell lymphoma 9.6
704 t-cell large granular lymphocyte leukemia 9.6
705 adrenal gland pheochromocytoma 9.6
706 inflammatory myofibroblastic tumor 9.6
707 immunoglobulin alpha deficiency 9.6
708 heavy chain disease 9.6
709 ischemic colitis 9.6
710 collagenous colitis 9.6
711 basal ganglia calcification 9.6
712 breast abscess 9.6
713 acrodermatitis chronica atrophicans 9.6
714 lymphoproliferative syndrome 9.6
715 salmonellosis 9.6
716 metaphyseal dysplasia 9.6
717 malignant pheochromocytoma 9.6
718 familial cold autoinflammatory syndrome 9.6
719 cholelithiasis 9.6
720 siderosis 9.6
721 dressler's syndrome 9.6
722 meningoencephalitis 9.6
723 charcot-marie-tooth disease 9.6
724 tropical sprue 9.6
725 protein-losing enteropathy 9.6
726 cystinosis 9.6
727 mastitis 9.6
728 renal hypertension 9.6
729 portal hypertension 9.6
730 filariasis 9.6
731 malignant hypertension 9.6
732 microcephaly 9.6
733 tooth disease 9.6
734 discitis 9.6
735 sarcoma 9.6
736 anhidrosis 9.6
737 respiratory failure 9.6
738 primary hyperparathyroidism 9.6
739 arteriovenous malformation 9.6
740 constrictive pericarditis 9.6
741 suppurative otitis media 9.6
742 emery-dreifuss muscular dystrophy 9.6
743 visual epilepsy 9.6
744 nephrotic syndrome 9.6
745 ischemic neuropathy 9.6
746 synostosis 9.6
747 ulnar nerve lesion 9.6
748 dengue disease 9.6
749 alcoholic hepatitis 9.6
750 bronchopneumonia 9.6
751 secondary hyperparathyroidism of renal origin 9.6
752 hepatitis a 9.6
753 posterior uveitis 9.6
754 nephrocalcinosis 9.6
755 nephronophthisis 9.6
756 telangiectasis 9.6
757 mikulicz disease 9.6
758 balanitis 9.6
759 megaloblastic anemia 9.6
760 scleritis 9.6
761 loiasis 9.6
762 cholestasis 9.6
763 phaeohyphomycosis 9.6
764 bicipital tenosynovitis 9.6
765 adult dermatomyositis 9.6
766 childhood type dermatomyositis 9.6
767 chronic purulent otitis media 9.6
768 adult-onset still's disease 9.6
769 sclerosing cholangitis 9.6
770 pyuria 9.6
771 neuronal ceroid lipofuscinosis 9.6
772 prostatitis 9.6
773 nodular nonsuppurative panniculitis 9.6
774 diffuse scleroderma 9.6
775 keratosis 9.6
776 ventricular septal defect 9.6
777 heart septal defect 9.6
778 ichthyosis 9.6
779 cheilitis 9.6
780 hypogonadism 9.6
781 autoimmune hepatitis 9.6
782 factor xiii deficiency 9.6
783 prothrombin deficiency 9.6
784 iron metabolism disease 9.6
785 benign mesothelioma 9.6
786 cryoglobulinemia 9.6
787 membranoproliferative glomerulonephritis 9.6
788 cystic kidney disease 9.6
789 primary hyperoxaluria 9.6
790 glioblastoma multiforme 9.6
791 gingival overgrowth 9.6
792 rhabdomyosarcoma 9.6
793 central nervous system disease 9.6
794 palmoplantar keratosis 9.6
795 plague 9.6
796 lactic acidosis 9.6
797 pulmonary fibrosis 9.6
798 granuloma annulare 9.6
799 hepatic tuberculosis 9.6
800 spindle cell sarcoma 9.6
801 polyradiculoneuropathy 9.6
802 erdheim-chester disease 9.6
803 extraosseous chondrosarcoma 9.6
804 subacute bacterial endocarditis 9.6
805 vasomotor rhinitis 9.6
806 benign ependymoma 9.6
807 thyroid gland disease 9.6
808 nutritional deficiency disease 9.6
809 chronic inflammatory demyelinating polyradiculoneuropathy 9.6
810 infertility 9.6
811 cellular ependymoma 9.6
812 median neuropathy 9.6
813 nerve compression syndrome 9.6
814 myxoid chondrosarcoma 9.6
815 double outlet right ventricle 9.6
816 bone lymphoma 9.6
817 monoclonal gammopathy of uncertain significance 9.6
818 malignant pleural mesothelioma 9.6
819 osgood-schlatter's disease 9.6
820 placenta disease 9.6
821 myocarditis 9.6
822 peritonitis 9.6
823 sezary's disease 9.6
824 nervous system disease 9.6
825 myeloid leukemia 9.6
826 pyomyositis 9.6
827 parapsoriasis 9.6
828 orbital plasma cell granuloma 9.6
829 intracranial hypertension 9.6
830 hypersensitivity vasculitis 9.6
831 toxoplasmosis 9.6
832 tertiary neurosyphilis 9.6
833 hypereosinophilic syndrome 9.6
834 trpv4-associated disorders 9.6
835 acute non lymphoblastic leukemia 9.6
836 antisynthetase syndrome 9.6
837 borrone di rocco crovato syndrome 9.6
838 chromosome 5q duplication 9.6
839 cold urticaria 9.6
840 congenital rubella 9.6
841 fibromatosis 9.6
842 granulocytopenia 9.6
843 hemangioendothelioma 9.6
844 light chain deposition disease 9.6
845 metatarsus adductus 9.6
846 mollaret meningitis 9.6
847 mycobacterium avium complex infections 9.6
848 papular mucinosis 9.6
849 perniosis 9.6
850 pituitary stalk interruption syndrome 9.6
851 polyarticular onset juvenile idiopathic arthritis 9.6
852 pure autonomic failure 9.6
853 remitting seronegative symmetrical synovitis with pitting edema 9.6
854 retroperitoneal fibrosis 9.6
855 singleton-merten syndrome 9.6
856 soft tissue sarcoma 9.6
857 wells syndrome 9.6
858 fainting 9.6
859 hypertonia 9.6
860 mucopolysaccharidoses 9.6
861 pituitary tumors 9.6
862 seizure disorder 9.6
863 rare systemic disease 9.6
864 epithelioid hemangioendothelioma 9.6
865 pulmonary arterial hypertension associated with portal hypertension 9.6
866 rare vascular tumor 9.6
867 isolated agammaglobulinemia 9.6
868 primary bone lymphoma 9.6
869 disorder of tyrosine metabolism 9.6
870 polyarticular juvenile idiopathic arthritis 9.6
871 polymerase proofreading-related adenomatous polyposis 9.6
872 epidermal disease 9.6
873 undetermined colitis 9.6
874 aortic aneurysm, familial abdominal, 1 9.6
875 pfeiffer syndrome 9.6
876 hajdu-cheney syndrome 9.6
877 amyloidosis, hereditary, transthyretin-related 9.6
878 apnea, obstructive sleep 9.6
879 behcet syndrome 9.6
880 hepatocellular carcinoma 9.6
881 cleft palate, isolated 9.6
882 coloboma of macula 9.6
883 corneal dystrophy, epithelial basement membrane 9.6
884 crouzon syndrome 9.6
885 ehlers-danlos syndrome, periodontal type, 1 9.6
886 camurati-engelmann disease 9.6
887 exostoses, multiple, type i 9.6
888 fingers, relative length of 9.6
889 hypertelorism 9.6
890 hypertension, essential 9.6
891 hypertriglyceridemia, familial 9.6
892 kaposi sarcoma 9.6
893 leiomyoma, uterine 9.6
894 motion sickness 9.6
895 myositis 9.6
896 nail-patella syndrome 9.6
897 otitis media 9.6
898 paroxysmal extreme pain disorder 9.6
899 papillomatosis, confluent and reticulated 9.6
900 parkinson disease, late-onset 9.6
901 greig cephalopolysyndactyly syndrome 9.6
902 hutchinson-gilford progeria syndrome 9.6
903 prostate cancer 9.6
904 dowling-degos disease 1 9.6
905 retinal detachment 9.6
906 scheuermann disease 9.6
907 schistosoma mansoni infection, susceptibility/ 9.6
908 small cell cancer of the lung 9.6
909 strabismus 9.6
910 tarsal coalition 9.6
911 digeorge syndrome 9.6
912 down syndrome 9.6
913 abetalipoproteinemia 9.6
914 anemia, autoimmune hemolytic 9.6
915 arterial calcification, generalized, of infancy, 1 9.6
916 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 9.6
917 bardet-biedl syndrome 1 9.6
918 lung cancer 9.6
919 hypoascorbemia 9.6
920 immune deficiency disease 9.6
921 leprosy 3 9.6
922 pancreatic cancer 9.6
923 pierre robin syndrome 9.6
924 spondyloepiphyseal dysplasia tarda, autosomal recessive 9.6
925 wilson disease 9.6
926 uruguay faciocardiomusculoskeletal syndrome 9.6
927 hypophosphatemic rickets, x-linked recessive 9.6
928 mend syndrome 9.6
929 alpha-thalassemia/mental retardation syndrome, x-linked 9.6
930 hemophilia a 9.6
931 taqi polymorphism 9.6
932 retinitis pigmentosa 13 9.6
933 prostatic hyperplasia, benign 9.6
934 craniosynostosis, adelaide type 9.6
935 cd4/cd8 t-cell ratio 9.6
936 hypocalcemia, autosomal dominant 1 9.6
937 amelia, posterior, with pelvic and pulmonary hypoplasia syndrome 9.6
938 stroke, ischemic 9.6
939 branchiootic syndrome 1 9.6
940 dermatitis, atopic 9.6
941 polydactyly 9.6
942 microvascular complications of diabetes 1 9.6
943 orthostatic intolerance 9.6
944 abdominal obesity-metabolic syndrome 1 9.6
945 late-onset retinal degeneration 9.6
946 aneurysmal bone cysts 9.6
947 alveolar soft part sarcoma 9.6
948 aortic aneurysm, familial thoracic 1 9.6
949 resting heart rate, variation in 9.6
950 epidermolysis bullosa simplex superficialis 9.6
951 hypertensive nephropathy 9.6
952 spondyloepiphyseal dysplasia, kimberley type 9.6
953 mevalonic aciduria 9.6
954 stature quantitative trait locus 14 9.6
955 microvascular complications of diabetes 2 9.6
956 microvascular complications of diabetes 5 9.6
957 fatty liver disease, nonalcoholic 1 9.6
958 plasminogen activator inhibitor-1 deficiency 9.6
959 mseleni joint disease 9.6
960 ectodermal dysplasia-syndactyly syndrome 2 9.6
961 gastric cancer 9.6
962 myopathy, distal, tateyama type 9.6
963 dengue virus 9.6
964 cerebellar ataxia, neuropathy, and vestibular areflexia syndrome 9.6
965 kosaki overgrowth syndrome 9.6
966 chorea, childhood-onset, with psychomotor retardation 9.6
967 mucopolysaccharidosis-plus syndrome 9.6
968 chronic ulcer of skin 9.6
969 chikungunya 9.6
970 ross river fever 9.6
971 inflammatory bowel disease 9.6
972 arterial calcification of infancy 9.6
973 metabolic acidosis 9.6
974 secondary progressive multiple sclerosis 9.6
975 oromandibular dystonia 9.6
976 chronic venous insufficiency 9.6
977 fibroma 9.6
978 ameloblastoma 9.6
979 bone chondrosarcoma 9.6
980 atrial fibrillation 9.6
981 gallbladder disease 9.6
982 pollen allergy 9.6
983 physical disorder 9.6
984 ankylosing spondylitis 1 9.6
985 middle east respiratory syndrome 9.6
986 alpha thalassemia-x-linked intellectual disability syndrome 9.6
987 hereditary mixed polyposis syndrome 9.6
988 sensorineural hearing loss 9.6
989 corneal disease 9.6
990 keratoconus 9.6
991 dermatomyositis 9.6
992 aortic atherosclerosis 9.6
993 thalassemia 9.6
994 sialadenitis 9.6
995 tonsillitis 9.6
996 patellar tendinitis 9.6
997 lactose intolerance 9.6
998 japanese encephalitis 9.6
999 q fever 9.6
1000 bartonellosis 9.6
1001 hydronephrosis 9.6
1002 pertussis 9.6
1003 t cell deficiency 9.6
1004 opioid abuse 9.6
1005 cat-scratch disease 9.6
1006 african histoplasmosis 9.6
1007 tetanus 9.6
1008 diphtheria 9.6
1009 lyme disease 9.6
1010 bronchial disease 9.6
1011 esophagitis 9.6
1012 cryptococcosis 9.6
1013 aseptic meningitis 9.6
1014 spinal muscular atrophy 9.6
1015 secondary hyperparathyroidism 9.6
1016 pes anserinus tendinitis or bursitis 9.6
1017 von willebrand's disease 9.6
1018 acute leukemia 9.6
1019 leiomyoma 9.6
1020 quadriplegia 9.6
1021 guillain-barre syndrome 9.6
1022 choreatic disease 9.6
1023 keratoconjunctivitis sicca 9.6
1024 vertebral artery insufficiency 9.6
1025 paronychia 9.6
1026 uveitis 9.6
1027 familial hypercholesterolemia 9.6
1028 benign paroxysmal positional nystagmus 9.6
1029 interstitial cystitis 9.6
1030 schistosomiasis 9.6
1031 calcific tendinitis 9.6
1032 hypophosphatasia 9.6
1033 sporotrichosis 9.6
1034 type i ehlers-danlos syndrome 9.6
1035 blount's disease 9.6
1036 avoidant personality disorder 9.6
1037 personality disorder 9.6
1038 urticaria 9.6
1039 chromoblastomycosis 9.6
1040 fungal infectious disease 9.6
1041 thrombocytopenia 9.6
1042 lymphadenitis 9.6
1043 skeletal tuberculosis 9.6
1044 chronic cystitis 9.6
1045 histoplasmosis 9.6
1046 pericarditis 9.6
1047 epilepsy 9.6
1048 dysostosis 9.6
1049 bardet-biedl syndrome 9.6
1050 hereditary multiple exostoses 9.6
1051 lateral sclerosis 9.6
1052 craniosynostosis 9.6
1053 glomus tumor 9.6
1054 glomangioma 9.6
1055 retinal vascular disease 9.6
1056 psychotic disorder 9.6
1057 reflex epilepsy 9.6
1058 hemangioma 9.6
1059 morphine dependence 9.6
1060 chondroma 9.6
1061 myoma 9.6
1062 pigmented villonodular synovitis 9.6
1063 tic disorder 9.6
1064 prostatic adenoma 9.6
1065 severe acute respiratory syndrome 9.6
1066 substance abuse 9.6
1067 acute kidney failure 9.6
1068 tenosynovial giant cell tumor 9.6
1069 scleredema adultorum 9.6
1070 lipomatosis 9.6
1071 mesenchymal cell neoplasm 9.6
1072 fibrosarcoma 9.6
1073 histiocytosis 9.6
1074 breast disease 9.6
1075 systemic mastocytosis 9.6
1076 turner syndrome 9.6
1077 mastocytosis 9.6
1078 plasmacytoma 9.6
1079 pleural empyema 9.6
1080 anterior compartment syndrome 9.6
1081 multidrug-resistant tuberculosis 9.6
1082 neuromuscular disease 9.6
1083 macular retinal edema 9.6
1084 hypokalemia 9.6
1085 uremia 9.6
1086 intracranial hypotension 9.6
1087 calciphylaxis 9.6
1088 somatoform disorder 9.6
1089 pancreatitis 9.6
1090 plexiform neurofibroma 9.6
1091 aortic disease 9.6
1092 human immunodeficiency virus infectious disease 9.6
1093 intestinal disease 9.6
1094 dystonia 9.6
1095 eye disease 9.6
1096 hemolytic anemia 9.6
1097 bronchitis 9.6
1098 acquired immunodeficiency syndrome 9.6
1099 premenstrual tension 9.6
1100 diverticulitis 9.6
1101 stomach disease 9.6
1102 parathyroid adenoma 9.6
1103 neuroblastoma 9.6
1104 end stage renal disease 9.6
1105 hyperthyroidism 9.6
1106 synovial angioma 9.6
1107 extrinsic allergic alveolitis 9.6
1108 localized scleroderma 9.6
1109 herpes zoster 9.6
1110 collagen disease 9.6
1111 herpes simplex 9.6
1112 chickenpox 9.6
1113 vein disease 9.6
1114 decubitus ulcer 9.6
1115 skin melanoma 9.6
1116 mechanical strabismus 9.6
1117 lymphangitis 9.6
1118 taylor's syndrome 9.6
1119 carotid artery dissection 9.6
1120 keratoconjunctivitis 9.6
1121 exophthalmos 9.6
1122 acute myocardial infarction 9.6
1123 miliary tuberculosis 9.6
1124 periostitis 9.6
1125 drug dependence 9.6
1126 hypoglycemia 9.6
1127 fgfr craniosynostosis syndromes 9.6
1128 hereditary multiple osteochondromas 9.6
1129 hereditary transthyretin amyloidosis 9.6
1130 sost-related sclerosing bone dysplasias 9.6
1131 trichorhinophalangeal syndrome 9.6
1132 type ii collagen disorders 9.6
1133 acute articular rheumatism 9.6
1134 acute mountain sickness 9.6
1135 bone marrow necrosis 9.6
1136 congenital femoral deficiency 9.6
1137 fetal thalidomide syndrome 9.6
1138 growth hormone deficiency 9.6
1139 haemophilus influenzae 9.6
1140 hansen's disease 9.6
1141 heparin-induced thrombocytopenia 9.6
1142 hip subluxation 9.6
1143 lymphomatous thyroiditis 9.6
1144 mycobacterium chelonae 9.6
1145 pediatric acute-onset neuropsychiatric syndrome 9.6
1146 persistent genital arousal disorder 9.6
1147 piriformis syndrome 9.6
1148 polymyositis 9.6
1149 rheumatoid vasculitis 9.6
1150 trichothiodystrophy 9.6
1151 cav3-related distal myopathy 9.6
1152 isolated pierre robin sequence 9.6
1153 anoxia 9.6
1154 autonomic dysfunction 9.6
1155 dysphagia 9.6
1156 foot drop 9.6
1157 headache 9.6
1158 hypotonia 9.6
1159 myoclonus 9.6
1160 paraneoplastic syndromes 9.6
1161 repetitive stress injuries 9.6
1162 syncope 9.6
1163 tremor 9.6
1164 systemic autoimmune disease 9.6
1165 cerebrofacial arteriovenous metameric syndrome 9.6
1166 inflammatory myopathy with abundant macrophages 9.6
1167 temporomandibular joint anomaly 9.6
1168 elastofibroma dorsi 9.6
1169 acute sensory ataxic neuropathy 9.6
1170 wild type attr amyloidosis 9.6
1171 ciliopathy 9.6
1172 amelia 9.6
1173 combined pulmonary fibrosis-emphysema syndrome 9.6
1174 chronic enteropathy associated with slco2a1 gene 9.6
1175 spontaneous intracranial hypotension 9.6
1176 argyria 9.6
1177 serotonin syndrome 9.6
1178 solitary bone cyst 9.6
1179 primary bone dysplasia with increased bone density 9.6
1180 multiple epiphyseal dysplasia and pseudoachondroplasia 9.6
1181 thyroid carcinoma 9.6

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (showing 23, show less)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Decubitus Ulcer
Deficiency Anemia Dysthymic Disorder
Esophagitis First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Iron Deficiency Anemia Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

Human phenotypes related to Osteoarthritis:

31 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 abnormality of pelvic girdle bone morphology 31 HP:0002644
2 hip osteoarthritis 31 HP:0008843

UMLS symptoms related to Osteoarthritis:


joint stiffness, arthralgia, tremor, back pain, angina pectoris, sciatica, equilibration disorder, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

Drugs & Therapeutics for Osteoarthritis

PubMed Health treatment related to Osteoarthritis: 62

There are many different suggestions and recommendations for treating osteoarthritis , but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible. There are two different types of therapies : Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy . The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle -strengthening exercises could help people with knee osteoarthritis . Other treatment options include massage , acupuncture , TENS, medicinal baths or orthopedic insoles. Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy ). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation . There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 611, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
6
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
7
Aceclofenac Approved, Investigational Phase 4 89796-99-6
8 Orange Approved Phase 4
9
Histamine Approved, Investigational Phase 4 51-45-6 774
10
Chlorzoxazone Approved Phase 4 95-25-0 2733
11
Ibuprofen Approved Phase 4 15687-27-1 3672
12
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
13
Promethazine Approved, Investigational Phase 4 60-87-7 4927
14
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
15
Zolpidem Approved Phase 4 82626-48-0 5732
16
Nabumetone Approved Phase 4 42924-53-8 4409
17
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
18
Denosumab Approved Phase 4 615258-40-7
19
Enoxaparin Approved Phase 4 9005-49-6 772
20
Rivaroxaban Approved Phase 4 366789-02-8
21
Piroxicam Approved, Investigational Phase 4 36322-90-4 5280452 54676228
22
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
23
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
24
Infliximab Approved Phase 4 170277-31-3
25
Prilocaine Approved Phase 4 721-50-6 4906
26
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
27
Dalteparin Approved Phase 4 9005-49-6
28
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
29
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
30
Zinc Approved, Investigational Phase 4 7440-66-6 32051
31
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
32
Hyoscyamine Approved Phase 4 101-31-5 64692
33
parecoxib Approved Phase 4 198470-84-7
34
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
35
Ticagrelor Approved Phase 4 274693-27-5 9871419
36
Rutin Approved, Experimental, Investigational Phase 4 153-18-4 5280805
37
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
38
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990