MCID: OST006
MIFTS: 38

Osteoblastoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Osteoblastoma

Summaries for Osteoblastoma

Disease Ontology : 12 A bone benign neoplasm of the bone that is characterized by clinical and histological similarity to osteoid osteomas.

MalaCards based summary : Osteoblastoma is related to aneurysmal bone cysts and fibrous dysplasia. An important gene associated with Osteoblastoma is MIR135B (MicroRNA 135b), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Corticotropin-releasing hormone signaling pathway. The drug Denosumab has been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and bone marrow, and related phenotypes are limbs/digits/tail and skeleton

Wikipedia : 73 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the... more...

Related Diseases for Osteoblastoma

Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 aneurysmal bone cysts 30.7 USP6 CDH11
2 fibrous dysplasia 30.1 SPARC FGF23 BGLAP
3 telangiectatic osteogenic sarcoma 29.9 USP6 CDH11
4 osteomalacia 29.7 MEPE FGF23 BGLAP
5 extraosseous osteosarcoma 29.5 SPARC SATB2 BGLAP
6 myositis ossificans 29.4 USP6 SPARC SATB2 FOS BGLAP
7 rickets 29.3 MEPE FGF23 BGLAP
8 osteoid osteoma 11.2
9 osteogenic sarcoma 10.8
10 scoliosis 10.6
11 rare tumor 10.5
12 fibroma 10.3
13 exophthalmos 10.3
14 ossifying fibroma 10.3
15 primary bone cancer 10.2
16 back pain 10.2
17 proliferative fasciitis 10.2 USP6 FOSB
18 histiocytoid hemangioma 10.2 FOSB FOS
19 intravascular fasciitis 10.2 USP6 CTNNB1
20 chondrosarcoma 10.2
21 torticollis 10.2
22 chondroma 10.2
23 atypical polypoid adenomyoma 10.1 SATB2 CTNNB1
24 chondroblastoma 10.1
25 radiculopathy 10.1
26 periostitis 10.1
27 osteochondroma 10.1
28 meningioma, familial 10.1
29 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.1
30 intracranial meningioma 10.1
31 osteomyelitis 10.1
32 facial paralysis 10.1
33 juxtacortical osteosarcoma 10.1
34 secretory meningioma 10.1
35 lymphoplasmacyte-rich meningioma 10.1
36 paraplegia 10.1
37 oncogenic osteomalacia 10.1 MEPE FGF23
38 conventional central osteosarcoma 10.0 USP6 SPARC SATB2
39 ischemic fasciitis 10.0 USP6 FOSB CDH11
40 fibrosarcomatous osteosarcoma 10.0 SPARC BGLAP
41 myositis 10.0
42 ameloblastoma 10.0
43 hydrocephalus 10.0
44 exostosis 10.0
45 juxtacortical chondroma 10.0
46 periosteal osteogenic sarcoma 10.0
47 juvenile ossifying fibroma 10.0
48 pseudosarcomatous fibromatosis 10.0 USP6 CTNNB1 CDH11
49 papillary cystadenocarcinoma 9.9 SPARC BGLAP
50 bone benign neoplasm 9.9 USP6 MIR135B BGLAP

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to Osteoblastoma

Symptoms & Phenotypes for Osteoblastoma

MGI Mouse Phenotypes related to Osteoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.5 CTNNB1 FGF23 FOS GPR108 SATB2 SLC39A14
2 skeleton MP:0005390 9.28 BGLAP CTNNB1 FGF23 FOS GPR108 MEPE

Drugs & Therapeutics for Osteoblastoma

Drugs for Osteoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Osteoblastoma

Cochrane evidence based reviews: osteoblastoma

Genetic Tests for Osteoblastoma

Anatomical Context for Osteoblastoma

MalaCards organs/tissues related to Osteoblastoma:

40
Bone, Thyroid, Bone Marrow, Spinal Cord, Smooth Muscle, Breast, Myeloid

Publications for Osteoblastoma

Articles related to Osteoblastoma:

(show top 50) (show all 1148)
# Title Authors PMID Year
1
TRPV4 activity regulates nuclear Ca2+ and transcriptional functions of β-catenin in a renal epithelial cell model. 61
33044004 2021
2
Unusual Osteoblastoma of the First Metatarsal Bone Treated by Total Resection and Fibular Autograft: A Case Report. 61
33798119 2021
3
A rare cause of exophthalmia: Osteoblastoma of the frontal sinus. 61
33664921 2021
4
Osteoblastoma of the mandible in a male patient: a case report. 61
33661117 2021
5
Laryngeal Osteoblastoma: Unusual Location in Arytenoid Cartilage. 61
33705054 2021
6
Aneurysmal bone cyst and osteoblastoma: an extremely rare combination in the pediatric spine. 61
33083998 2021
7
An Intraoperative Surprise! A Rare Case Report of Primary Craniovertebral Junction Hydatid Disease Mimicking a Bony Tumor. 61
33220475 2021
8
A Frontal Osteoblastoma in a Middle-Aged Woman Mimicking a Meningioma. 61
32732077 2021
9
Ligustilide inhibits the proliferation of human osteoblastoma MG63 cells through the TLR4-ERK pathway. 61
33545202 2021
10
Bone Tumours of the Talus: 18-Year Cohort of Patients With Rare Osteoid Lesions. 61
33791180 2021
11
Significant Improvement After Surgery for a Symptomatic Osteoblastoma in a Patient with Camurati-Engelmann Disease: Case Report and Literature Review. 61
33555353 2021
12
Rib Osteoblastoma as a Cause of Neurogenic Thoracic Outlet Syndrome: A Case Report. 61
33556044 2021
13
Safety and Feasibility of Cervical Pedicle Screw Insertion in Pediatric Subaxial Cervical Spine Without Navigation: A Retrospective Cohort Study. 61
33027234 2021
14
Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. 61
33181515 2021
15
Usefulness of β-catenin expression in the differential diagnosis of osteosarcoma, osteoblastoma, and chondroblastoma. 61
33511430 2021
16
Image-guided Cryotherapy for Musculoskeletal Tumors. 61
32842945 2021
17
Typical and Atypical Radiographic Features of Symptomatic Osteoblastoma in the Spine. 61
33065353 2021
18
Paediatric fronto-orbital osteoblastoma: case report. 61
33427543 2021
19
Osteoblastoma of Talus: A Diagnostic Dilemma. 61
33409078 2020
20
Isolated osteoblastoma of the cuboid bone: A case report and review of the literature. 61
33039906 2020
21
The malignant transformation of osteoid osteoma in the cervical spine to high-grade osteosarcoma: a case report and review of literature. 61
33140986 2020
22
Aggressive Osteoblastoma Involving the Navicular Bone of Foot: A Rare Tumor in a Unique Location. 61
32950371 2020
23
SATB2 is not a reliable diagnostic marker for distinguishing between oral osteosarcoma and fibro-osseous lesions of the jaws. 61
33309262 2020
24
[Tumors affecting the temporomandibular joint - a literature review]. 61
33059872 2020
25
Spinal osteoblastoma: a retrospective study of 35 patients' imaging findings with an emphasis on MRI. 61
33226535 2020
26
Pediatric cranial osteoblastoma: Technical note of surgical treatment and review of the literature. 61
33049284 2020
27
Loss of NF2 defines a genetic subgroup of non-FOS-rearranged osteoblastoma. 61
32542935 2020
28
Aggressive Cranial Osteoblastoma of the Parietotemporo-Occipital Bone: A Case Report and Review of Literature with Special Emphasis on Recurrence/Residue. 61
32569763 2020
29
A complex histopathological challenge: suspicion of an osteoblastoma-like osteosarcoma arising from the second thoracic vertebra in a cat. 61
33028314 2020
30
Atypical Enostoses-Series of Ten Cases and Literature Review. 61
33065973 2020
31
The minimally invasive endoscopic technique for the treatment of symptomatic benign bone lesions: Preliminary results from a retrospective study. 61
32817813 2020
32
Minimally Invasive Resection of a Pediatric Lumbar Osteoblastoma: Case Report. 61
32506134 2020
33
Laryngeal Osteoblastoma: Unusual Location in Arytenoid Cartilage. 61
32890170 2020
34
Percutaneous cryoablation of osteoblastoma in the proximal femur. 61
32166366 2020
35
Lumbar Spine Osteoblastoma with Secondary Aneurysmal Bone Cyst Causing Severe Trunk Imbalance and Radiculopathy: A Case Report. 61
33489962 2020
36
Osteoblastoma of Mandible in Child: A Case Report. 61
33149535 2020
37
Clinicopathologic study of 6 cases of epithelioid osteoblastoma of the jaws with immunoexpression analysis of FOS and FOSB. 61
32482537 2020
38
Dark as night: Spelunking for spinal solitary fibrous tumors/hemangiopericytomas in the differential of T2 hypointensity. 61
32507710 2020
39
Report of 3 cases of pediatric sinus osteomas with osteoblastoma-like features. 61
32419894 2020
40
Intracranial bony ball - An ossified variant of meningioma. 61
32769336 2020
41
Lumbar Extraosseous Intraforaminal Osteoblastoma: Case Report and Review of the Literature. 61
32217174 2020
42
Laminopedicular Osteotomy for En-bloc Resection of Posterolateral Thoracic Osteoblastoma: Technical Note. 61
32251818 2020
43
Correction to: The one-in-all diagnostic value of 99mTcMDP bone scan combining with singlephoton emission tomography (SPECT)/CT imaging in spinal osteoblastoma. 61
32580734 2020
44
Spinal Tumor Ablation: Indications, Techniques, and Clinical Management. 61
32591193 2020
45
Bone Tumors: Benign Bone Tumors. 61
32573182 2020
46
Bone up on spinal osseous lesions: a case review series. 61
32601958 2020
47
Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. 61
32036238 2020
48
Spinal osteoid osteoma recurring as an aggressive osteoblastoma. 61
31488355 2020
49
Osteoblastoma in the occipital bone: A case report of a rare tumor in the calvarium. 61
32215163 2020
50
The one-in-all diagnostic value of 99mTc-MDP bone scan combining with single-photon emission tomography (SPECT)/CT imaging in spinal osteoblastoma. 61
32448317 2020

Variations for Osteoblastoma

Expression for Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for Osteoblastoma

Pathways related to Osteoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 FOS FGF23 BGLAP
2 11.1 FOSB FOS CTNNB1
3 10.47 FOS FGF23 BGLAP
4 10.3 FGF23 BGLAP

GO Terms for Osteoblastoma

Biological processes related to Osteoblastoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.67 FOSB FOS CTNNB1 BGLAP
2 ossification GO:0001503 9.61 SPARC CDH11 BGLAP
3 regulation of bone mineralization GO:0030500 9.49 FGF23 BGLAP
4 response to corticosterone GO:0051412 9.48 FOSB FOS
5 osteoblast development GO:0002076 9.46 SATB2 BGLAP
6 response to mechanical stimulus GO:0009612 9.43 FOSB FOS BGLAP
7 regulation of osteoclast differentiation GO:0045670 9.4 CTNNB1 BGLAP
8 response to cAMP GO:0051591 9.33 SPARC FOSB FOS
9 cellular response to vitamin D GO:0071305 9.32 FGF23 BGLAP
10 skeletal system development GO:0001501 9.26 MEPE CTNNB1 CDH11 BGLAP
11 response to gravity GO:0009629 8.8 SPARC FOS BGLAP

Sources for Osteoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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