MCID: OST006
MIFTS: 34

Osteoblastoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Osteoblastoma

Summaries for Osteoblastoma

MalaCards based summary : Osteoblastoma is related to osteoid osteoma and scoliosis. An important gene associated with Osteoblastoma is CTNNB1 (Catenin Beta 1). The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the... more...

Related Diseases for Osteoblastoma

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to Osteoblastoma

Symptoms & Phenotypes for Osteoblastoma

GenomeRNAi Phenotypes related to Osteoblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.4 NELL1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.4 CTNNB1 NELL1 SPARC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.4 CTNNB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NELL1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.4 SPARC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.4 NELL1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.4 SPARC
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 NELL1 SPARC
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.4 NELL1

MGI Mouse Phenotypes related to Osteoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 CTNNB1 KREMEN1 SLC39A14 SPARC

Drugs & Therapeutics for Osteoblastoma

Drugs for Osteoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Osteoblastoma

Cochrane evidence based reviews: osteoblastoma

Genetic Tests for Osteoblastoma

Anatomical Context for Osteoblastoma

MalaCards organs/tissues related to Osteoblastoma:

41
Bone, Thyroid, Spinal Cord, Pineal, Bone Marrow, Pancreas, Breast

Publications for Osteoblastoma

Articles related to Osteoblastoma:

(show top 50) (show all 601)
# Title Authors Year
1
A case of spinal osteoblastoma in the elderly: is it really a young patient's disease? ( 29421450 )
2018
2
A rare case of osteoblastoma from medieval Tuscany. ( 29304355 )
2018
3
Large Paediatric Central Osteoma with Osteoblastoma-Like Features in the Mandible. ( 29508129 )
2018
4
Aggressive osteoblastoma of the acetabulum: A diagnostic dilemma. ( 29928098 )
2018
5
Osteoblastoma of the mandible: A rare locally aggressive benign tumour. ( 29779915 )
2018
6
Neoadjuvant denosumab for the treatment of a sacral osteoblastoma. ( 29356985 )
2018
7
Osteoblastoma of the Hard Palate in a Child: A Rare Case. ( 29808179 )
2018
8
Recurrent rearrangements of FOS and FOSB define osteoblastoma. ( 29858576 )
2018
9
Periosteal osteoblastoma of the distal fibula with atypical radiological features: a case report. ( 29957764 )
2018
10
Giant periosteal aggressive epithelioid osteoblastoma: 21-year-old male presents case in the midshaft of his femur. ( 29525944 )
2018
11
Pseudomalignant osteoblastoma of the odontoid process. ( 29380146 )
2018
12
Eccentric, mature osseous cap: A distinct imaging feature of sinonasal osteoblastoma. ( 29644901 )
2018
13
A rare cause of type 1 complex regional pain syndrome: Osteoblastoma of the talus. ( 30100373 )
2018
14
Osteoblastoma-like osteosarcoma: high-grade or low-grade osteosarcoma? ( 30152881 )
2018
15
Bilateral Transorbital and Transnasal Endoscopic Resection of a Frontal Sinus Osteoblastoma and Orbital Mucocele: A Case Report and Review of the Literature. ( 30187776 )
2018
16
A rare case of giant osteoblastoma of the sacrum. ( 30194630 )
2018
17
Cytological diagnosis of osteoblastoma of the talus: Case report with unusual presentation and diagnostic pitfalls. ( 30197661 )
2018
18
Osteoblastoma of the frontal bone invading the orbital roof: A case report. ( 30334973 )
2018
19
Factors Affecting Prognosis of Patients With Osteoblastoma of the Mobile Spine: A Long-Term Follow-up Study of 70 Patients in a Single Center. ( 30481353 )
2018
20
Epithelioid Osteoblastoma of the Temporal Bone: A Case Report. ( 30521959 )
2018
21
Commentary: Factors Affecting Prognosis of 70 Patients With Osteoblastoma in the Mobile Spine: A Long-Term Follow-Up Study of a Large Case Series in a Single Center. ( 30541102 )
2018
22
Osteoblastoma of the elbow: analysis of 13 patients and literature review. ( 28634923 )
2017
23
Osteoblastoma Mimicking an Idiopathic Intracranial Hypertension Syndrome. ( 28553393 )
2017
24
Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. ( 27853880 )
2017
25
Suboccipital osteoblastoma: Microsurgical resection of a rare entity. ( 28458947 )
2017
26
Aggressive Osteoblastoma in the Maxilla: Unusual Lesion in the Craniofacial Skeleton. ( 28468168 )
2017
27
Percutaneous radiofrequency ablation for spinal osteoid osteoma and osteoblastoma. ( 28391383 )
2017
28
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. ( 28479709 )
2017
29
microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation. ( 28460435 )
2017
30
A rare case of osteoblastoma combined with severe scoliosis deformity, coronal and sagittal imbalance. ( 29258494 )
2017
31
Rare Aggressive Calvarial Osteoblastoma with Dural Invasion. ( 29204329 )
2017
32
Spinal osteoid osteoma progressed to osteoblastoma with paraspinal soft tissue mass: a unique presentation. ( 27999873 )
2017
33
Aggressive Osteoblastoma in the Maxilla: Unusual Lesion in the Craniofacial Skeleton. ( 28277479 )
2017
34
CT-guided radiofrequency ablation of spinal osteoblastoma: treatment and long-term follow-up. ( 28597707 )
2017
35
Elevated I^-hCG associated with aggressive Osteoblastoma. ( 28396962 )
2017
36
Osteoblastoma of the hamate bone - a case report. ( 28905333 )
2017
37
Breast osteoblastoma and recurrence after resection: Demonstration by color Doppler ultrasound. ( 28506022 )
2017
38
Preoperative Embolization and Complete Tumoral Resection of a Cervical Aggressive Epithelioid Osteoblastoma. ( 28710051 )
2017
39
Activation of the arachidonic acid metabolic pathway and induction of sleep disturbance by sacral osteoblastoma: A case report. ( 28781793 )
2017
40
Clinics in diagnostic imaging (174). L5 vertebral superior facet osteoblastoma (OB). ( 28210742 )
2017
41
Clinical management of a challenging malignancy, osteoblastoma-like osteosarcoma: a report of four cases and a review of the literature. ( 27574436 )
2016
42
Osteoblastoma of the thyroid cartilage. ( 27206395 )
2016
43
Agressive osteoblastoma in a seven-year-old girl's mandible: Treatment and six-year monitoring. ( 27518431 )
2016
44
The effect of simple local resection on pain and scoliotic curve in patients with scoliosis secondary to osteoid osteoma and osteoblastoma in the spine. ( 27130390 )
2016
45
Aggressive osteoblastoma of the cervical spine involving the canal and vertebral artery: a case report. ( 27981453 )
2016
46
Malignant transformation of a high-grade osteoblastoma of the petrous apex with subcutaneous metastasis. ( 27304442 )
2016
47
Osteoblastoma of the temporal articular tubercle misdiagnosed asA a temporomandibular joint disorder. ( 28043747 )
2016
48
Orbital Osteoblastoma: Technical Innovations in Resection and Reconstruction Using Virtual Surgery Simulation. ( 27516847 )
2016
49
Removal of osteoblastoma of the talar neck using standard anterior ankle Arthroscopyi19A case report. ( 27100951 )
2016
50
Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos. ( 26895762 )
2016

Variations for Osteoblastoma

Expression for Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for Osteoblastoma

GO Terms for Osteoblastoma

Cellular components related to Osteoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 ADCY1 CTNNB1 KREMEN1 SLC39A14 SPARC USP6
2 Schaffer collateral - CA1 synapse GO:0098685 8.96 ADCY1 CTNNB1

Biological processes related to Osteoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of osteoblast differentiation GO:0045669 9.32 CTNNB1 NELL1
2 cellular response to growth factor stimulus GO:0071363 9.26 CTNNB1 SPARC
3 limb development GO:0060173 9.16 CTNNB1 KREMEN1
4 Wnt signaling pathway GO:0016055 9.13 CTNNB1 KREMEN1 ZNRF3
5 regulation of canonical Wnt signaling pathway GO:0060828 8.8 CTNNB1 KREMEN1 ZNRF3

Sources for Osteoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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