Osteochondritis Dissecans (OCD)

Categories: Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Osteochondritis Dissecans

MalaCards integrated aliases for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 12 74 20 58 29 6 44 15 37 71 32
Osteochondritis 44 71
Kônig Disease 20
König Disease 20
Konig Disease 58
Ocd 12


Orphanet epidemiological data:

osteochondritis dissecans
Age of onset: All ages; Age of death: normal life expectancy;


Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases

External Ids:

Disease Ontology 12 DOID:84
ICD9CM 34 732.7
SNOMED-CT 67 156821002 70736000
ICD10 32 M93.2 M93.9
MESH via Orphanet 45 D010008
ICD10 via Orphanet 33 M93.2
UMLS via Orphanet 72 C0029421
Orphanet 58 ORPHA2764
UMLS 71 C0029420 C0029421

Summaries for Osteochondritis Dissecans

GARD : 20 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. If the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. However, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. Although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. In most cases, the exact underlying cause is unknown. Rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the ACAN gene and is inherited in an autosomal dominant manner. Treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy.

MalaCards based summary : Osteochondritis Dissecans, also known as osteochondritis, is related to familial osteochondritis dissecans and osteochondrosis. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Anesthetics and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include epiphysis, bone and bone marrow, and related phenotypes are joint stiffness and arthralgia

Disease Ontology : 12 An ischemic bone disease that results in necrosis located in epiphysis.

Wikipedia : 74 Osteochondritis dissecans (OCD or OD) is a joint disorder primarily of the subchondral bone in which... more...

Related Diseases for Osteochondritis Dissecans

Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
# Related Disease Score Top Affiliating Genes
1 familial osteochondritis dissecans 32.9 TNR FBLN2 FBLN1 ACAN
2 osteochondrosis 31.9 MATN3 COMP COL9A3 COL9A2 COL9A1 CD36
3 epiphyseal dysplasia, multiple, 2 31.8 MATN3 COMP COL9A3 COL9A2 COL9A1
4 chondromalacia 30.6 COMP ACAN
5 exostosis 30.5 MMP13 BMP2 ACAN
6 coxa vara 30.4 PRG4 MMP13
7 synovitis 30.4 PRG4 MMP3 MMP13 COMP ACAN
8 multiple epiphyseal dysplasia 30.3 MATN3 COMP COL9A3 COL9A2 COL9A1 ACAN
9 synovial chondromatosis 30.1 SOX9 BMP2
10 spondyloepiphyseal dysplasia with congenital joint dislocations 30.1 COMP COL9A3 COL9A2 COL9A1 ACAN
11 stickler syndrome 29.9 SOX9 MATN3 COL9A3 COL9A2 COL9A1 ACAN
12 patella, chondromalacia of 29.8 COMP ACAN
13 bone inflammation disease 29.8 MMP3 MMP13 GAPDH COMP ACAN
14 osteoarthritis 29.7 SOX9 PRG4 MMP3 MMP13 MATN3 COMP
15 arthropathy 29.6 PRG4 MMP3 MMP13 COMP ACAN
16 scoliosis 29.6 SOX9 MMP3 MMP13 COMP ACAN
17 cleft palate, isolated 29.5 SOX9 COL9A2 COL9A1 BMP7 BMP2
18 brittle bone disorder 29.2 SOX9 MMP13 COMP CD36 BMP7 BMP2
19 cartilage disease 28.8 SOX9 PRG4 MMP3 MMP13 COMP BMP2
20 odontochondrodysplasia 28.7 SOX9 MMP13 MATN3 GAPDH COMP COL9A3
21 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.0
22 obsessive-compulsive disorder 11.9
23 idiopathic avascular necrosis 11.8
24 loeys-dietz syndrome 3 11.2
25 gilles de la tourette syndrome 11.1
26 kohler's disease 11.1
27 pediatric acute-onset neuropsychiatric syndrome 11.0
28 body dysmorphic disorder 11.0
29 trichotillomania 11.0
30 achilles bursitis 11.0
31 scheuermann disease 10.9
32 ruvalcaba syndrome 10.9
33 bazex syndrome 10.9
34 early congenital syphilis 10.9
35 dystonia 11, myoclonic 10.9
36 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 10.9
37 choreoacanthocytosis 10.9
38 succinic semialdehyde dehydrogenase deficiency 10.9
39 chromosome 3pter-p25 deletion syndrome 10.9
40 neurotic disorder 10.9
41 bain type of x-linked syndromic intellectual disability 10.9
42 pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 10.9
43 pacs1 syndrome 10.9
44 legg-calve-perthes disease 10.7
45 osteonecrosis 10.7
46 anxiety 10.7
47 plica syndrome 10.6
48 avascular necrosis 10.6
49 tic disorder 10.5
50 depression 10.5

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:

Diseases related to Osteochondritis Dissecans

Symptoms & Phenotypes for Osteochondritis Dissecans

Human phenotypes related to Osteochondritis Dissecans:

58 31 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint stiffness 58 31 hallmark (90%) Very frequent (99-80%) HP:0001387
2 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
3 joint swelling 58 31 hallmark (90%) Very frequent (99-80%) HP:0001386
4 abnormality of the knee 58 31 hallmark (90%) Very frequent (99-80%) HP:0002815
5 limited elbow extension 58 31 frequent (33%) Frequent (79-30%) HP:0001377
6 decreased hip abduction 58 31 frequent (33%) Frequent (79-30%) HP:0003184
7 limited elbow flexion 58 31 frequent (33%) Frequent (79-30%) HP:0006376
8 gait disturbance 58 31 occasional (7.5%) Occasional (29-5%) HP:0001288
9 abnormality of tibia morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002992
10 quadriceps muscle atrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009050
11 limitation of joint mobility 58 Very frequent (99-80%)
12 abnormal joint morphology 58 Frequent (79-30%)
13 abnormality of skeletal physiology 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CD36 COL9A2 MMP3 PRG4

MGI Mouse Phenotypes related to Osteochondritis Dissecans:

# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 BMP2 BMP7 CD36 COL9A3 COMP FBLN1
2 cardiovascular system MP:0005385 10.07 BMP2 BMP7 CD36 COL9A3 COMP FBLN1
3 immune system MP:0005387 9.85 BMP2 BMP7 CD36 COL9A1 COL9A3 COMP
4 hearing/vestibular/ear MP:0005377 9.8 BMP2 BMP7 COL9A1 COL9A2 COL9A3 FBLN1
5 limbs/digits/tail MP:0005371 9.61 BMP2 BMP7 COL9A1 COL9A2 COMP FBLN1
6 skeleton MP:0005390 9.4 BMP2 BMP7 CD36 COL9A1 COL9A2 COMP

Drugs & Therapeutics for Osteochondritis Dissecans

Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2, Phase 3
2 Fibrin Tissue Adhesive Phase 3
3 Mitogens Phase 3
Becaplermin Approved, Investigational 165101-51-9
Acetaminophen Approved 103-90-2 1983
6 Astragalus
7 Anesthetics, Local
8 Calamus
9 Calcium, Dietary
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 76)
# Name Status NCT ID Phase Drugs
1 Multicenter Randomized Controlled Trial for the Treatment of Knee Chondral and Osteochondral Lesions: Marrow Stimulation Techniques vs MaioRegen Completed NCT01282034 Phase 4
2 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
3 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
4 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
5 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
6 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
7 Evaluation of the Composite of Cancellous and Demineralized Bone Plug (CR Plug) for Repair of Defects Created at the Harvest Site During the Osteochondral Autograft Transfer System(OATS)Procedure Completed NCT00821873 Phase 3
8 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
9 Randomized, Multicentric, Prospective, Double-blind Study: Effectiveness of Adding Allogenic Stem Cells to a Platelet-poor Plasma Scaffold After Arthroscopic Debridement and Microfractures in Patients With Osteochondral Lesions of the Talus Recruiting NCT03905824 Phase 3
10 A Multi-center, Single-blind, Randomized, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Adding CARTISTEM® on Microfracture in Patients With Talar Chondral or Osteochondral Defect Enrolling by invitation NCT04310215 Phase 3
11 Evaluation of the Composite of Cancellous and Demineralized Bone Plug (CR-Plug) for Repair of Osteochondral Defects in High-Load-Bearing Region and Low-Load-Bearing Region of the Femoral Condyle Terminated NCT00984594 Phase 3
12 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
13 Treatment of Osteochondral Lesion of Talus With Processed Osteochondral Allograft Unknown status NCT02736318 Phase 1, Phase 2
14 Second Line Treatment of Knee Osteochondral Lesion With Decellularized Treated Osteochondral Allograft. Phase IIa Trial Unknown status NCT02430558 Phase 1, Phase 2
15 Repair of Articular Osteochondral Defect Unknown status NCT01409447
16 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
17 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
18 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
19 "One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions Unknown status NCT02005861
20 Mesenchymal Stem Cell Transplantation in the Treatment of Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
21 Clinical and Radiological Results of Osteochondral Repair Using MaioRegen in Knee and Ankle Surgery Unknown status NCT02345564
22 Comparing Outcomes of Microfracture Versus Microfracture and Bone Marrow Aspirate Concentrate for the Treatment of Osteochondral Lesions of the Talus Unknown status NCT03856021
23 Clinical Trial of the Safety and Efficacy of Allogenic Umbilical Cord Blood-derived Mesenchymal Stem Cell Product With Microfracture for Osteochondral Lesion of Talus Patients Unknown status NCT02338375 Early Phase 1
24 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Unknown status NCT03625180
25 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Completed NCT01471236
26 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Completed NCT01754298
27 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Completed NCT02397278 Platelet rich plasma (PRP)
28 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
29 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
30 Bone Marrow Aspirate Concentrate Supplementation to Microfracture in the Treatment of Osteochondral Lesions of the Talus Completed NCT02011295
31 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Completed NCT02423629
32 A Pilot Study to Augment™ Bone Graft Plus Evaluate the Safety of Allograft for Treatment of Osteochondral Defects (OCD) of the Knee Completed NCT01290991
33 Observational Studies, Prospective, Multicenter, to Evaluate the Effect of Treatment of Knee Osteochondral Lesions of Outerbridge Grade III-IV Completed NCT01554878
34 Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions ("EAGLE") European Post Market Study Completed NCT02309957
35 Psychological Response and Readiness to Return to Sports Associated With the Diagnosis and Treatment of Osteochondritis Dissecans of the Knee Recruiting NCT04649905
36 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Recruiting NCT01405664
37 Prospective 2-year Data Collection of the First 10 Patients After Ankle Spacer Recruiting NCT04297449
38 Collecting Diagnostic, Treatment and Follow-up Data on Knee Treatments. Recruiting NCT04364334
39 Study Protocol for a Prospective Observational Study to Evaluate the Clinical and Imaging Results of the Fresh Osteochondral Allograft Transplantation for Osteochondral Knee Lesions Recruiting NCT04236492
40 A Prospective, Multi-Center Study Evaluating ProChondrix® CR for the Repair of Focal Articular Cartilage Defects in the Knee Recruiting NCT03873545
41 Multicentric Observational Study on the Use of a Human Bone Graft in Osteochondral Defects Recruiting NCT03777735
42 Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results Recruiting NCT03908931
43 Indications for Osteochondral Allograft Transplantation by Evaluating Safety and Efficacy of Total Biologic Total Joint Replacement of Ankle Post-traumatic Osteoarthritis (PTOA) Recruiting NCT03711747
44 Valutazione Dell'Epidemiologia e Dei Risultati Radiografici e Clinici Nel Trattamento Artroscopico Delle Lesioni Osteocondrali Dell'Astragalo Con Tecnica AMIC Recruiting NCT03371121
45 A Prospective, Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Episealer® Knee System Compared to Microfracture for the Treatment of Focal Femoral Knee Chondral or Osteochondral Lesions Recruiting NCT04000659
46 Detection by Digital PCR and Next Generation Sequencing of Recurrent Mutations in Waldenström's Disease and Study of Their Distribution in the Different Biological Compartments Recruiting NCT03952052
47 Introduction of Autologous Chondrocyte Implantation Procedure for the Treatment of Chondral Defect in the Knee Recruiting NCT04296487
48 National Prospective and Retrospective Follow-up of Patients With COVID-19 Infected Chronic Lymphocytic Leukemia / Lymphocytic Lymphoma or Waldenström Disease Recruiting NCT04391946
49 A Pilot Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects of the Talus Recruiting NCT03696394
50 Prospective, Randomized, Single Blind Clinical Trial to Investigate the Impact of Autologous Bone Marrow Concentrate in Knee Osteochondral Allograft Transplantation Recruiting NCT04739930

Search NIH Clinical Center for Osteochondritis Dissecans

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: osteochondritis

Genetic Tests for Osteochondritis Dissecans

Genetic tests related to Osteochondritis Dissecans:

# Genetic test Affiliating Genes
1 Osteochondritis Dissecans 29 ACAN

Anatomical Context for Osteochondritis Dissecans

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondritis Dissecans:


MalaCards organs/tissues related to Osteochondritis Dissecans:

Bone, Bone Marrow, Skin, Pituitary

Publications for Osteochondritis Dissecans

Articles related to Osteochondritis Dissecans:

(show top 50) (show all 2475)
# Title Authors PMID Year
A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans. 61 6
20137779 2010
14216462 1964
Identification of a novel heterozygous mutation of the Aggrecan gene in a family with idiopathic short stature and multiple intervertebral disc herniation. 6
28331218 2017
ACAN Gene Mutations in Short Children Born SGA and Response to Growth Hormone Treatment. 6
27710243 2017
Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations. 6
27870580 2017
Idiopathic short stature due to novel heterozygous mutation of the aggrecan gene. 6
25741789 2015
Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations. 6
24762113 2014
Tennis overuse injuries in the upper extremity. 61
33009583 2021
Prevalence of hypovitaminosis D in patients with juvenile osteochondritis dissecans. 61
33281101 2021
Canine Elbow Dysplasia: Ununited Anconeal Process, Osteochondritis Dissecans, and Medial Coronoid Process Disease. 61
33558015 2021
The Use of Elbow Arthroscopy for Management of the Pediatric Elbow: A Systematic Review of Indications and Outcomes. 61
33539972 2021
Predictors of Failure of Return to Play in Youth Baseball Players After Capitellar Osteochondritis Dissecans: Focus on Elbow Valgus Laxity and Radiocapitellar Congruity. 61
33321050 2021
Osteochondral autograft transplantation versus autologous bone-cartilage paste grafting for the treatment of knee osteochondritis dissecans. 61
32959150 2021
Editorial Commentary: Early Operative Management of "Stable" Osteochondritis Dissecans Lesions Confers Greater Value in Skeletally Immature Patients. 61
33546800 2021
Cost-Effectiveness Analysis of Nonoperative Management Versus Early Drilling for Stable Osteochondritis Dissecans Lesions of the Knee in Skeletally Immature Patients. 61
33271176 2021
Ankle Morphology and Juvenile Osteochondritis Dissecans (JOCD) of the Talus: Is There an Association? An MRI Study. 61
33229961 2021
The nonoperative treatment of osteochondritis dissecans of the knee. 61
33315689 2021
Surgical Fixation of Chondral-Only Fragments of the Knee: A Case Series With a Mean 4-Year Follow-up. 61
33521156 2021
Management of bilateral osteochondritis dissecans of the trochlea in a skeletally immature patient. 61
33504536 2021
A novel three-dimensional MRI-CT image fusion technique for precise preoperative evaluation and treatment of capitellar osteochondritis dissecans. 61
33454801 2021
Performance of PROMIS Scores Compared to Legacy Metrics in Evaluating Outcomes after Surgical Treatment for Osteochondritis Dissecans of the Humeral Capitellum. 61
33486062 2021
Lateral wall fixation with bone pegs for advanced osteochondritis dissecans of the humeral capitellum. 61
33554161 2021
Multiple Osteochondritis Dissecans in Multiple Joints. 61
33575051 2021
Predictive factors for developing osteochondritis dissecans after surgery for discoid lateral meniscus are younger age and shorter meniscal width. 61
31642945 2021
What's New in Osteochondritis Dissecans of the Knee, Elbow, and Ankle. 61
33438926 2021
Distinguishing between congenital phenomena and traumatic experiences: Osteochondrosis versus osteochondritis. 61
33551611 2021
Progression of Epiphyseal Cartilage and Bone Pathology in Surgically Treated Cases of Osteochondritis Dissecans of the Elbow. 61
33196301 2021
Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans. 61
33423507 2021
Evaluation and Surgical Management of Knee Osteochondritis Dissecans and Adolescent Cartilage Injuries. 61
33438925 2021
A novel mutation in the ACAN gene in a family with autosomal dominant short stature and intervertebral disc disease. 61
33298914 2020
Dual diagnosis of osteogenesis imperfecta (OI) and short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD) reveals a cumulative effect on stature caused by mutations in COL1A1 and ACAN genes. 61
32980524 2020
Clinical and Radiographic Outcomes After Fixation of Chondral Fragments of the Knee in 6 Adolescents Using Autologous Bone Pegs. 61
33457431 2020
Osteochondral Autograft Transfer for Capitellar Chondral and Osteochondral Defects. 61
33294333 2020
Risk factors for hospital admission in patients undergoing outpatient anterior cruciate ligament reconstruction: A national database study. 61
33071518 2020
The incidence and risk factors of osteoarthritis following osteochondritis dissecans of the knees: a systematic review and meta-analysis. 61
33211214 2020
Overuse Knee Pain in the Pediatric and Adolescent Athlete. 61
33156034 2020
A Modification of the Cheli Craniolateral Approach for Minimally Invasive Treatment of Osteochondritis Dissecans of the Shoulder in Dogs: Description of the Technique and Outcome in 164 Cases. 61
33232983 2020
Bioabsorbable Unsintered Hydroxyapatite/Poly-l-Lactic Acid Pin Fixation of Osteochondritis Dissecans in Adolescents: Initial Experiences. 61
33233012 2020
Open Treatment for Unstable Osteochondritis Dissecans of the Knee: Autologous Bone Grafting and Bioabsorbable Fixation. 61
33294340 2020
Radiography and Standing Computed Tomography of an Osteochondritis Dissecans Lesion Found at the Dorsodistolateral Aspect of the Calcaneus in a 3-Year-Old Horse. 61
33077099 2020
Is There a Role for Ultrasound in Hip Arthroscopy? A Systematic Review. 61
33135007 2020
Arthroscopic Meniscopexy for the Treatment of Nontraumatic Osteochondritis Dissecans in the Knee Joint of Adult Patients. 61
30221986 2020
Osteochondritis Dissecans of the Lateral Process of Talus Involving the Subtalar Joint: An Unusual Case. 61
33509717 2020
Retrospective evaluation of outcomes of bone peg fixation for osteochondral lesion of the talus. 61
32993333 2020
Factors Related to Postoperative Osteochondritis Dissecans of the Lateral Femoral Condyle After Meniscal Surgery in Juvenile Patients With a Discoid Lateral Meniscus. 61
32658153 2020
Satisfaction With Elbow Function and Return Status After Autologous Osteochondral Transplant for Capitellar Osteochondritis Dissecans in High School Baseball Players. 61
32941055 2020
Shoulder and Elbow Injuries in the Adolescent Throwing Athlete. 61
32872686 2020
MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T. 61
32278071 2020
Treatment of Juvenile Knee Osteochondritis Dissecans with a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and MRI Results at Mid-Term Follow-up. 61
32909451 2020
Stable clinical long term results after AMIC in the aligned knee. 61
32794150 2020

Variations for Osteochondritis Dissecans

ClinVar genetic disease variations for Osteochondritis Dissecans:

6 (show all 24)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ACAN NM_001369268.1(ACAN):c.1425del (p.Val478fs) Deletion Pathogenic 440750 rs1555454630 15:89389109-89389109 15:88845878-88845878
2 ACAN NM_001369268.1(ACAN):c.1745del (p.Phe582fs) Deletion Pathogenic 440753 rs1555455057 15:89392680-89392680 15:88849449-88849449
3 ACAN NM_001369268.1(ACAN):c.2026+1G>A SNV Pathogenic 440745 rs1555455127 15:89392963-89392963 15:88849732-88849732
4 ACAN NM_001369268.1(ACAN):c.4657G>T (p.Glu1553Ter) SNV Pathogenic 440748 rs1555456128 15:89400473-89400473 15:88857242-88857242
5 ACAN NM_001369268.1(ACAN):c.7317G>A (p.Trp2439Ter) SNV Pathogenic 440751 rs1555457632 15:89416126-89416126 15:88872895-88872895
6 ACAN NM_001369268.1(ACAN):c.7178T>C (p.Leu2393Pro) SNV Pathogenic 440746 rs1555457513 15:89414730-89414730 15:88871499-88871499
7 ACAN NM_001369268.1(ACAN):c.223T>C (p.Trp75Arg) SNV Pathogenic 440749 rs1555453695 15:89382046-89382046 15:88838815-88838815
8 ACAN NM_001369268.1(ACAN):c.7204C>T (p.Gln2402Ter) SNV Pathogenic 440752 rs1555457525 15:89414756-89414756 15:88871525-88871525
9 ACAN NM_001369268.1(ACAN):c.273del (p.Arg93fs) Deletion Pathogenic 440744 rs1555453708 15:89382095-89382095 15:88838864-88838864
10 ACAN NM_001369268.1(ACAN):c.5391del (p.Gln1798fs) Deletion Pathogenic 440747 rs1555456230 15:89401205-89401205 15:88857974-88857974
11 ACAN NM_001369268.1(ACAN):c.2541del (p.Val848fs) Deletion Pathogenic 803118 rs1596144242 15:89398352-89398352 15:88855121-88855121
12 ACAN NM_001369268.1(ACAN):c.7363G>A (p.Val2455Met) SNV Pathogenic 14306 rs267606625 15:89416172-89416172 15:88872941-88872941
13 ACAN NM_001369268.1(ACAN):c.221dup (p.Trp75fs) Duplication Likely pathogenic 976161 15:89382042-89382043 15:88838811-88838812
14 ACAN NM_001369268.1(ACAN):c.-7-2A>T SNV Likely pathogenic 635418 rs1596128699 15:89379429-89379429 15:88836198-88836198
15 ACAN NM_001369268.1(ACAN):c.1193T>A (p.Ile398Asn) SNV Uncertain significance 444004 rs1555454545 15:89388877-89388877 15:88845646-88845646
16 ACAN NM_001369268.1(ACAN):c.7358A>T (p.Asp2453Val) SNV Uncertain significance 252934 rs879255506 15:89416167-89416167 15:88872936-88872936
17 ACAN NM_001369268.1(ACAN):c.1955C>T (p.Thr652Met) SNV Uncertain significance 873431 15:89392891-89392891 15:88849660-88849660
18 ACAN NM_001369268.1(ACAN):c.7327C>A (p.Gln2443Lys) SNV Uncertain significance 975866 15:89416136-89416136 15:88872905-88872905
19 ACAN NM_001369268.1(ACAN):c.130G>A (p.Gly44Arg) SNV Uncertain significance 975885 15:89381953-89381953 15:88838722-88838722
20 ACAN NM_001369268.1(ACAN):c.2153C>A (p.Thr718Lys) SNV Uncertain significance 976016 15:89395151-89395151 15:88851920-88851920
21 ACAN NM_001369268.1(ACAN):c.962A>G (p.Asn321Ser) SNV Uncertain significance 976069 15:89386790-89386790 15:88843559-88843559
22 ACAN NM_001369268.1(ACAN):c.230G>A (p.Arg77His) SNV Likely benign 446080 rs199701329 15:89382053-89382053 15:88838822-88838822
23 ACAN NM_001369268.1(ACAN):c.913C>T (p.Arg305Cys) SNV Likely benign 803117 rs372895171 15:89386741-89386741 15:88843510-88843510
24 ACAN NM_001369268.1(ACAN):c.824G>A (p.Arg275Gln) SNV Benign 803116 rs34949187 15:89386652-89386652 15:88843421-88843421

Expression for Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for Osteochondritis Dissecans

Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.22 PRG4 MMP3 MMP13 COL9A3 COL9A2 COL9A1
Show member pathways
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Show member pathways
12.64 MMP3 MMP13 COL9A3 COL9A2 COL9A1
Show member pathways
Show member pathways
9 11.74 SOX9 BMP7 BMP2 ACAN
Show member pathways
11 11.48 SOX9 MMP13 BMP7 ACAN
13 11.24 COL9A3 COL9A2 COL9A1
15 10.9 BMP7 BMP2
16 10.77 PRG4 COL9A3 COL9A2 COL9A1 BMP7 BMP2

GO Terms for Osteochondritis Dissecans

Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.11 TNR MMP3 MMP13 FBLN1 COMP COL9A3
2 extracellular region GO:0005576 10 TNR PRG4 MMP3 MMP13 MATN3 FBLN2
3 endoplasmic reticulum lumen GO:0005788 9.73 MATN3 COL9A3 COL9A2 COL9A1
4 collagen trimer GO:0005581 9.72 MMP13 COL9A3 COL9A2 COL9A1 CD36
5 basement membrane GO:0005604 9.71 FBLN1 COL9A3 COL9A1 ACAN
6 collagen-containing extracellular matrix GO:0062023 9.7 TNR PRG4 MATN3 FBLN2 FBLN1 COMP
7 collagen type IX trimer GO:0005594 9.43 COL9A3 COL9A2 COL9A1
8 extracellular matrix GO:0031012 9.36 TNR MMP3 MMP13 MATN3 FBLN2 FBLN1

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 SOX9 FBLN1 CD36 BMP7 BMP2
2 animal organ morphogenesis GO:0009887 9.76 COMP COL9A1 BMP7 BMP2
3 BMP signaling pathway GO:0030509 9.74 COMP BMP7 BMP2
4 cartilage development GO:0051216 9.63 SOX9 MMP13 MATN3 COMP BMP7 BMP2
5 ossification GO:0001503 9.62 SOX9 COMP BMP7 BMP2
6 response to fatty acid GO:0070542 9.61 SOX9 CD36
7 bone mineralization GO:0030282 9.61 MMP13 COMP BMP2
8 cartilage condensation GO:0001502 9.6 SOX9 ACAN
9 endocardial cushion morphogenesis GO:0003203 9.59 SOX9 BMP2
10 positive regulation of cartilage development GO:0061036 9.58 SOX9 BMP2
11 response to amyloid-beta GO:1904645 9.58 MMP3 MMP13
12 epithelial to mesenchymal transition GO:0001837 9.58 SOX9 BMP7 BMP2
13 mesenchymal cell differentiation GO:0048762 9.55 BMP7 BMP2
14 growth plate cartilage development GO:0003417 9.54 MMP13 COMP
15 cellular response to BMP stimulus GO:0071773 9.54 SOX9 BMP7 BMP2
16 regulation of removal of superoxide radicals GO:2000121 9.52 CD36 BMP7
17 endocardial cushion formation GO:0003272 9.51 BMP7 BMP2
18 skeletal system development GO:0001501 9.5 SOX9 MATN3 COMP COL9A2 BMP7 BMP2
19 positive regulation of chondrocyte proliferation GO:1902732 9.49 SOX9 COMP
20 mesenchyme development GO:0060485 9.48 BMP7 BMP2
21 chondrocyte development GO:0002063 9.43 SOX9 COMP ACAN
22 extracellular matrix organization GO:0030198 9.4 TNR SOX9 MMP3 MMP13 MATN3 FBLN2

Molecular functions related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.63 MMP13 MATN3 FBLN2 FBLN1 COMP ACAN
2 extracellular matrix structural constituent conferring compression resistance GO:0030021 9.32 PRG4 ACAN
3 BMP receptor binding GO:0070700 9.26 BMP7 BMP2
4 extracellular matrix structural constituent GO:0005201 9.23 MATN3 FBLN2 FBLN1 COMP COL9A3 COL9A2
5 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL9A3 COL9A2 COL9A1

Sources for Osteochondritis Dissecans

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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