MCID: OST028
MIFTS: 51

Osteochondroma

Categories: Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Osteochondroma

MalaCards integrated aliases for Osteochondroma:

Name: Osteochondroma 54 56 17
Cartilaginous Exostosis 74

Classifications:



External Ids:

UMLS 74 C0029423

Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and dysplasia epiphysealis hemimelica. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Etoricoxib and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Osteochondromas are the most common benign tumors of the bones. The tumors take the form of... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 hereditary multiple osteochondromas 34.7 EXT1 EXT2
2 dysplasia epiphysealis hemimelica 31.0 EXT1 EXT2
3 chondrosarcoma 30.9 EXT1 EXT2 FGF2 PTHLH
4 juxtacortical chondroma 30.2 EXT1 PTHLH
5 muenke syndrome 29.7 EXT1 FGF2 FGF9 FGFR1 FGFR3
6 synovial chondromatosis 29.7 BMP2 FGF2 FGF9 FGFR1 FGFR3
7 syringoma 29.6 S100B VIM
8 ewing sarcoma 28.4 CDKN1A FGF2 FGFR1 NES S100B TGFB2
9 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.1
10 exostoses, multiple, type i 12.0
11 carpotarsal osteochondromatosis 11.8
12 metachondromatosis 11.7
13 exostoses, multiple, type ii 11.7
14 hereditary multiple exostoses 11.7
15 exostoses, multiple, type iii 11.3
16 potocki-shaffer syndrome 11.1
17 exostosis 10.4
18 clear cell chondrosarcoma 10.4 EXT2 PTHLH
19 multiple enchondromatosis, maffucci type 10.4 EXT1 EXT2
20 thrombosis 10.3
21 plagiocephaly 10.3 FGFR1 FGFR3
22 osteoglophonic dysplasia 10.3 FGFR1 FGFR3
23 enchondromatosis, multiple, ollier type 10.3 EXT1 EXT2 PTHLH
24 frozen shoulder 10.3
25 bursitis 10.3
26 benign metastasizing leiomyoma 10.2 BCL2 VIM
27 clear cell adenoma 10.2 PTHLH S100B
28 crouzon syndrome 10.2 FGF2 FGFR1 FGFR3
29 rosette-forming glioneuronal tumor 10.2 FGFR1 S100B
30 hydromyelia 10.2 S100B VIM
31 dysembryoplastic neuroepithelial tumor 10.2 NES S100B
32 bone disease 10.2 EXT1 EXT2 FGFR3 PTHLH
33 bednar tumor 10.2 S100B VIM
34 lacrimoauriculodentodigital syndrome 10.2 FGF9 FGFR1 FGFR3
35 primary hepatic neuroendocrine carcinoma 10.2 S100B VIM
36 syringocystadenoma papilliferum 10.2 S100B VIM
37 ossifying fibromyxoid tumor 10.1 S100B VIM
38 head injury 10.1 BCL2 S100B
39 fibrous meningioma 10.1 S100B VIM
40 chordoid meningioma 10.1 S100B VIM
41 eccrine porocarcinoma 10.1 S100B VIM
42 periosteal chondrosarcoma 10.1 EXT1 PTHLH
43 ependymoblastoma 10.1 NES VIM
44 peroneal nerve paralysis 10.1
45 myxopapillary ependymoma 10.1 S100B VIM
46 astroblastoma 10.1 NES VIM
47 monophasic synovial sarcoma 10.1 S100B VIM
48 fibrodysplasia ossificans progressiva 10.1
49 meningioma, familial 10.1
50 pseudoarthrosis 10.1

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.64 E2F1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.64 BCL2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.64 BCL2 BMP2 CDKN1A E2F1 FGFR1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.64 CDKN1A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.64 BCL2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.64 BCL2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.64 E2F1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.64 FGFR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.64 CDKN1A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.64 FGFR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.64 E2F1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.64 BMP2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.64 BCL2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.64 BCL2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.64 BCL2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.64 CDKN1A
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.64 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

47 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
2 behavior/neurological MP:0005386 10.36 BCL2 CDKN1A E2F1 EXT1 FGF2 FGF9
3 craniofacial MP:0005382 10.34 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
4 embryo MP:0005380 10.32 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
5 mortality/aging MP:0010768 10.32 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
6 cardiovascular system MP:0005385 10.31 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
7 growth/size/body region MP:0005378 10.31 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
8 homeostasis/metabolism MP:0005376 10.31 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
9 digestive/alimentary MP:0005381 10.29 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF9
10 hearing/vestibular/ear MP:0005377 10.26 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF2
11 hematopoietic system MP:0005397 10.25 BCL2 BMP2 CDKN1A E2F1 FGF2 FGFR1
12 endocrine/exocrine gland MP:0005379 10.18 BCL2 BMPR1B CDKN1A E2F1 FGF9 FGFR1
13 immune system MP:0005387 10.18 BCL2 BMP2 CDKN1A E2F1 FGFR1 FGFR3
14 nervous system MP:0003631 10.18 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
15 integument MP:0010771 10.16 BCL2 CDKN1A E2F1 EXT1 FGF9 FGFR1
16 limbs/digits/tail MP:0005371 10.15 BMP2 BMPR1B CDKN1A EXT1 FGF9 FGFR1
17 muscle MP:0005369 10.06 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
18 reproductive system MP:0005389 10.03 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
19 normal MP:0002873 10.02 BMP2 BMPR1B E2F1 EXT1 FGF9 FGFR1
20 neoplasm MP:0002006 9.98 BCL2 CDKN1A E2F1 EXT1 FGF2 FGFR3
21 renal/urinary system MP:0005367 9.87 BCL2 CDKN1A FGF9 FGFR1 FGFR3 PTHLH
22 skeleton MP:0005390 9.73 BMP2 BMPR1B CDKN1A E2F1 EXT1 EXT2
23 respiratory system MP:0005388 9.7 CDKN1A E2F1 FGF9 FGFR3 PTHLH TGFB2
24 vision/eye MP:0005391 9.4 BCL2 BMPR1B CDKN1A E2F1 EXT1 FGF2

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Peripheral Nervous System Agents Phase 4
10 Antirheumatic Agents Phase 4
11 Narcotics Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Analgesics Phase 4
14 Analgesics, Opioid Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Cyclooxygenase Inhibitors Phase 4
17 Cyclooxygenase 2 Inhibitors Phase 4
18 Central Nervous System Depressants Phase 4
19 Autonomic Agents Phase 4
20 Neuroprotective Agents Phase 4
21 Antiemetics Phase 4
22 Gastrointestinal Agents Phase 4
23 Hormones Phase 4
24 Methylprednisolone Acetate Phase 4
25 glucocorticoids Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
27 Protective Agents Phase 4
28 Prednisolone acetate Phase 4
29 Hormone Antagonists Phase 4
30
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 444795 5538

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4 etoricoxib;tramadol
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Predicting Response to Intra-Articular Corticosteroid Injection in Patients With Osteoarthritis of the Glenohumeral Joint Recruiting NCT03232749 Phase 4 corticosteroid injections
5 Autologous Stem Cells in Achilles Tendinopathy Unknown status NCT02064062 Phase 2
6 Flexible Footwear and Insole in Heel Pain Unknown status NCT03040557 Phase 1, Phase 2
7 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
8 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Unknown status NCT02934100 Not Applicable
9 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
10 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
11 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393 Not Applicable
12 The Effect of High Intensity Laser Therapy in the Management of Painful Calcaneal Spur Completed NCT03907085 Not Applicable
13 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
14 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
15 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
16 Effect of Chosen Treatment Methods in Patients With Cervical Spine Osteoarthritis Completed NCT03683602 Not Applicable
17 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
18 The Effect of Kinesio-tape and Shock Wave Therapy on Plantar Fasciitis Recruiting NCT03904966 Not Applicable
19 Superior Capsule Reconstruction vs Partial Repair of Massive Rotator Cuff Tears Recruiting NCT03617562 Not Applicable
20 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
21 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

42
Bone, Spinal Cord, Bone Marrow, Tongue, Prostate, Uterus, Lymph Node

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 1178)
# Title Authors Year
1
Huge Bursitis and Bursal Synovial Osteochondromatosis Associated With Scapular Osteochondroma Mimicking a Giant Calcific Mass of the Chest Wall. ( 29905601 )
2019
2
A Rare Case of Tibioperoneal Arterial Trunk Entrapment Caused by a Fibular Osteochondroma. ( 30218831 )
2019
3
A rare case of osteochondroma of the coccyx. ( 30232956 )
2019
4
Regression of a solitary osteochondroma of the distal humerus in a toddler following trauma. ( 30425771 )
2019
5
Osteochondroma of the scapula associated with a subclavian artery pseudoaneurysm: Case report. ( 30675356 )
2019
6
Knee locked in flexion: incarcerated semitendinosus tendon around a proximal tibial osteochondroma. ( 30788088 )
2019
7
Pediatric navicular dorsal osteochondroma: a rare case of navicular-cuneiform impingement. ( 30855546 )
2019
8
Snapping Knee due to a Femoral Osteochondroma after Total Knee Arthroplasty. ( 30893994 )
2019
9
Subvastus approach for resection of subvastus osteochondroma in the distal femur. ( 31036474 )
2019
10
Extraskeletal Osteochondroma of the Great Toe in a Teenager. ( 31079982 )
2019
11
Osteochondroma condyle: A journey of 20 years in a 52-year-old male patient causing severe facial asymmetry and occlusal derangement. ( 31110443 )
2019
12
Transpedicular Excision of a Thoracic Intraspinal Osteochondroma in a Patient with Hereditary Multiple Exostoses and Brown-Séquard Syndrome. ( 29258931 )
2018
13
Huge Bursitis Associated With Scapular Osteochondroma Presenting as a Giant Mass of the Chest Wall: A Case Presentation. ( 29524608 )
2018
14
Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion. ( 29596896 )
2018
15
Proximal Tibial Osteochondroma Leading to Chronic Compartment Syndrome. ( 30173694 )
2018
16
Solitary anterior osteochondroma of cervical spine: An unusual cause of dysphagia and review of literature. ( 29928094 )
2018
17
Surgical Management of Onychopapilloma, Onychomatricoma, and Subungual Osteochondroma: Case Series. ( 30533990 )
2018
18
Rare Osteochondroma Associated with Natural Mortality of a Wild White-Tailed Deer ( Odocoileus virginianus). ( 29369726 )
2018
19
Post-traumatic osteochondroma of the distal femur. ( 29487657 )
2018
20
Occlusal adjustment after local resection of type 1 condylar osteochondroma. ( 29517694 )
2018
21
Novel exostosin-2 mutation identified in a Chinese family with hereditary multiple osteochondroma. ( 29541207 )
2018
22
Solitary facet joint osteochondroma of the upper thoracic spine: An unusual cause of cord compression in the pediatric age group. ( 29547195 )
2018
23
Incidental finding of pelvic osteochondroma. ( 29548897 )
2018
24
Ulnar Lengthening/Reconstruction of Interosseous Membrane in Treatment of Osteochondroma. ( 29576923 )
2018
25
Scapular osteochondroma with winging: A case report. ( 29614444 )
2018
26
Solitary osteochondroma of the capitate, in a child. ( 29628715 )
2018
27
Solitary Osteochondroma of the Ventral Scapula Associated with Large Bursa Formation and Pseudowinging of the Scapula: A Case Report and Literature Review. ( 29666735 )
2018
28
Osteochondroma of the Zygomatic Arch: A Case Report and Review of the Literature. ( 29684307 )
2018
29
Peripheral Osteochondroma of Buccal Mucosa. ( 29690980 )
2018
30
Osteochondroma of ventral scapula associated with chest pain due to rib cage compression: A case report. ( 29703017 )
2018
31
Multiple Hereditary Exostoses with Tetraparesis Due To Cervical Spine Osteochondroma. ( 29783013 )
2018
32
Osteochondroma of the Scapula with Accessory Nerve (XI) Compression. ( 29785314 )
2018
33
Insufficiency fracture at an osteochondroma bridging the proximal fibula and the tibia: Case report. ( 29881159 )
2018
34
Digital cutting guide and endoscopically-assisted vertical ramus osteotomy to treat condylar osteochondroma: a long-term study. ( 29895393 )
2018
35
Solitary Osteochondroma of the Spine-A Case Series: Review of Solitary Osteochondroma With Myelopathic Symptoms. ( 29977716 )
2018
36
Solitary osteochondroma in the body of the pubic bone: a cadaveric case report. ( 29984059 )
2018
37
Patellar Osteochondroma: A Unique Presentation. ( 30084584 )
2018
38
Osteoblastic Osteosarcoma Arising beneath an Osteochondroma in an 11-Year-Old Male with Multiple Hereditary Exostoses. ( 30123601 )
2018
39
Treatment of spinal cord compression caused by C2 osteochondroma with reconstruction and fusion after total resection: Case report and literature review. ( 30207870 )
2018
40
Large rib osteochondroma in a child in Aleppo, Syria. ( 30254734 )
2018
41
A pseudoaneurysm of the popliteal artery probably pierced by a bone spike arising in the spontaneously regressed osteochondroma: A case report. ( 30318426 )
2018
42
Osteochondroma of scapular body-trans-scapular technique of resection: a case report. ( 30340808 )
2018
43
An Unusual Presentation of Osteochondroma on the Dorsal Surface of the Scapula: A Review of Two Patients. ( 30584513 )
2018
44
Osteochondroma of the First Phalanx in Tbourida Horses. ( 30671439 )
2018
45
A Rare Clinical Presentation of an Osteochondroma of Coronoid Process of Mandible. ( 30680307 )
2018
46
Clavicular Osteochondroma: Extremely Rare Cause of Impingement Syndrome. ( 30915294 )
2018
47
Paraarticular osteochondroma of a lumbar facet joint presenting with radiculopathy. ( 27503186 )
2018
48
Solitary osteochondroma of the sinus tarsi. ( 28244886 )
2018
49
Comparison of the clinical effects of treatment of osteochondroma by two types of vertical ramus osteotomy. ( 28249702 )
2018
50
Osteochondroma of the Hyoid: First Pediatric Case and Literature Review. ( 28728426 )
2018

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
2
Show member pathways
13.67 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
3
Show member pathways
13.49 BCL2 BMP2 CDKN1A FGF2 FGF9 FGFR1
4
Show member pathways
13.33 BCL2 CDKN1A FGF2 FGF9 FGFR1 FGFR3
5
Show member pathways
13.33 BCL2 BMP2 BMPR1B CDKN1A FGF2 FGFR1
6
Show member pathways
13.25 BCL2 BMP2 BMPR1B FGF2 FGFR1 FGFR3
7
Show member pathways
13.24 BMP2 FGF2 FGFR1 FGFR3 TGFB2 VIM
8
Show member pathways
12.89 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
9
Show member pathways
12.84 BCL2 CDKN1A E2F1 FGFR1 TGFB2
10 12.74 FGF2 FGF9 FGFR1 FGFR3 TGFB2
11
Show member pathways
12.7 CDKN1A FGF2 FGF9 FGFR1 FGFR3
12
Show member pathways
12.67 BMP2 FGF2 FGFR1 FGFR3 TGFB2
13 12.58 FGF2 FGF9 FGFR1 FGFR3
14
Show member pathways
12.53 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
15
Show member pathways
12.51 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
16
Show member pathways
12.49 EXT1 EXT2 FGFR1 PTHLH
17
Show member pathways
12.41 FGF2 FGF9 FGFR1 FGFR3
18
Show member pathways
12.41 BCL2 BMPR1B FGFR1 FGFR3
19
Show member pathways
12.41 BMP2 BMPR1B E2F1 FGF2 TGFB2
20
Show member pathways
12.39 FGF2 FGF9 FGFR1 FGFR3
21
Show member pathways
12.37 FGF2 FGF9 FGFR1 FGFR3
22
Show member pathways
12.37 BMP2 FGF2 FGFR1 FGFR3 TGFB2
23 12.36 BCL2 CDKN1A E2F1 FGFR3 TGFB2 VIM
24 12.33 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
25 12.27 CDKN1A FGF2 FGFR1 TGFB2
26
Show member pathways
12.25 FGF2 FGF9 FGFR1 FGFR3
27
Show member pathways
12.21 BMP2 FGF2 FGFR1 FGFR3 TGFB2
28
Show member pathways
12.12 FGF2 FGF9 FGFR1 FGFR3
29
Show member pathways
12.12 BCL2 CDKN1A E2F1 FGFR1 FGFR3
30 12.05 BCL2 CDKN1A E2F1 FGFR1 FGFR3
31 12.04 BMPR1B FGF2 FGFR1 FGFR3
32 11.96 BCL2 BMP2 CDKN1A E2F1 TGFB2
33 11.93 BCL2 CDKN1A FGF2 VIM
34 11.89 FGF2 FGFR1 FGFR3
35 11.88 BCL2 CDKN1A FGFR1 PTHLH
36 11.87 BCL2 BMP2 CDKN1A E2F1
37 11.85 BCL2 CDKN1A E2F1
38 11.84 BMP2 BMPR1B TGFB2
39
Show member pathways
11.83 FGF2 FGF9 FGFR1
40
Show member pathways
11.81 BCL2 BMP2 CDKN1A FGF2 FGFR1 FGFR3
41 11.77 FGF2 FGFR1 FGFR3 TGFB2
42 11.72 CDKN1A E2F1 FGFR3
43 11.68 BMP2 FGF2 FGFR1 FGFR3 TGFB2
44
Show member pathways
11.61 FGF2 FGF9 FGFR3
45 11.59 BCL2 BMP2 CDKN1A E2F1 TGFB2
46 11.5 FGF2 FGFR1 TGFB2
47 11.47 BCL2 CDKN1A E2F1
48 11.43 FGF2 FGFR1 FGFR3
49 11.37 FGF2 FGFR1 FGFR3 PTHLH TGFB2
50 11.06 FGF2 FGF9 FGFR1 FGFR3

GO Terms for Osteochondroma

Cellular components related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 BMP2 FGF2 FGF9 FGFR1 FGFR3 PTHLH

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 BCL2 BMP2 CDKN1A PTHLH TGFB2
2 cytokine-mediated signaling pathway GO:0019221 9.97 BCL2 CDKN1A FGF2 VIM
3 angiogenesis GO:0001525 9.93 FGF2 FGF9 FGFR1 TGFB2
4 MAPK cascade GO:0000165 9.91 FGF2 FGF9 FGFR1 FGFR3
5 cellular response to hypoxia GO:0071456 9.88 BCL2 E2F1 S100B
6 negative regulation of cell growth GO:0030308 9.88 BCL2 CDKN1A TGFB2
7 animal organ morphogenesis GO:0009887 9.87 BCL2 BMP2 FGF2
8 positive regulation of protein kinase B signaling GO:0051897 9.86 FGF2 FGF9 FGFR1 FGFR3
9 male gonad development GO:0008584 9.85 BCL2 FGF9 TGFB2
10 cell differentiation GO:0030154 9.85 BMP2 BMPR1B EXT2 FGF2 FGF9
11 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.82 BMP2 FGF2 FGFR3
12 response to glucocorticoid GO:0051384 9.78 BCL2 CDKN1A S100B
13 SMAD protein signal transduction GO:0060395 9.77 BMP2 TGFB2 VIM
14 cell-cell signaling GO:0007267 9.77 BMP2 FGF9 FGFR3 PTHLH TGFB2
15 positive regulation of cell proliferation GO:0008284 9.76 BCL2 FGF2 FGF9 FGFR1 FGFR3 PTHLH
16 embryonic limb morphogenesis GO:0030326 9.75 FGF9 FGFR1 TGFB2
17 positive regulation of cell division GO:0051781 9.72 FGF2 FGF9 TGFB2
18 branching involved in ureteric bud morphogenesis GO:0001658 9.71 BCL2 BMP2 FGF2
19 ossification GO:0001503 9.71 BCL2 BMP2 EXT1 EXT2
20 embryonic digestive tract development GO:0048566 9.7 FGF9 TGFB2
21 endocardial cushion morphogenesis GO:0003203 9.69 BMP2 TGFB2
22 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.69 EXT1 EXT2
23 positive regulation of cartilage development GO:0061036 9.69 BMP2 BMPR1B
24 bone mineralization GO:0030282 9.69 BMP2 FGFR3 PTHLH
25 ear development GO:0043583 9.68 BCL2 FGFR1
26 positive regulation of ossification GO:0045778 9.68 BMP2 TGFB2
27 cardiac epithelial to mesenchymal transition GO:0060317 9.67 BMP2 TGFB2
28 generation of neurons GO:0048699 9.67 FGFR1 TGFB2
29 positive regulation of cardiac muscle cell proliferation GO:0060045 9.67 FGF2 FGF9 FGFR1
30 pathway-restricted SMAD protein phosphorylation GO:0060389 9.66 BMP2 TGFB2
31 positive regulation of phospholipase C activity GO:0010863 9.66 FGF2 FGFR1
32 atrioventricular valve morphogenesis GO:0003181 9.65 BMP2 TGFB2
33 mesenchymal cell differentiation GO:0048762 9.65 BMP2 FGFR1
34 salivary gland morphogenesis GO:0007435 9.65 FGFR1 TGFB2
35 eye development GO:0001654 9.65 BMPR1B FGF9 TGFB2
36 positive regulation of MAPK cascade GO:0043410 9.65 BMP2 DUSP19 FGF9 FGFR1 FGFR3
37 stem cell proliferation GO:0072089 9.64 FGF2 NES
38 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.63 EXT1 EXT2
39 lung-associated mesenchyme development GO:0060484 9.62 FGF9 FGFR1
40 positive regulation of phospholipase activity GO:0010518 9.62 FGFR1 FGFR3
41 fibroblast growth factor receptor signaling pathway GO:0008543 9.62 FGF2 FGF9 FGFR1 FGFR3
42 peptidyl-tyrosine phosphorylation GO:0018108 9.57 FGFR1 FGFR3
43 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.52 FGF2 FGFR1
44 cellular polysaccharide biosynthetic process GO:0033692 9.43 EXT1 EXT2
45 chondrocyte differentiation GO:0002062 9.35 BMP2 BMPR1B FGF9 FGFR1 FGFR3
46 skeletal system development GO:0001501 9.17 BMP2 BMPR1B EXT1 FGFR1 FGFR3 PTHLH
47 protein phosphorylation GO:0006468 10.08 BMP2 BMPR1B FGFR1 FGFR3 TGFB2
48 regulation of signaling receptor activity GO:0010469 10 BMP2 FGF2 FGF9 PTHLH TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 BCL2 EXT1 EXT2 FGFR1 S100B TGFB2
2 protein heterodimerization activity GO:0046982 9.85 BCL2 BMP2 EXT1 EXT2 TGFB2
3 growth factor activity GO:0008083 9.67 BMP2 FGF2 FGF9 TGFB2
4 fibroblast growth factor-activated receptor activity GO:0005007 9.4 FGFR1 FGFR3
5 protein tyrosine kinase activity GO:0004713 9.32 FGFR1 FGFR3
6 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.26 EXT1 EXT2
7 receptor-receptor interaction GO:0090722 9.16 FGF2 FGFR1
8 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.96 EXT1 EXT2
9 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.62 EXT1 EXT2

Sources for Osteochondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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