MCID: OST028
MIFTS: 49

Osteochondroma

Categories: Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Osteochondroma

MalaCards integrated aliases for Osteochondroma:

Name: Osteochondroma 53 29 55
Cartilaginous Exostosis 73

Classifications:



External Ids:

UMLS 73 C0029423

Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and chondrosarcoma. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Tramadol and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Osteochondromas are the most common benign tumors of the bones. The tumors take the form of... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 hereditary multiple osteochondromas 34.4 EXT1 EXT2
2 chondrosarcoma 30.8 EXT1 EXT2 FGF2 PTHLH
3 dysplasia epiphysealis hemimelica 30.7 EXT1 EXT2
4 synovial chondromatosis 29.9 BMP2 FGF2 FGF9 FGFR1 FGFR3
5 muenke syndrome 29.8 EXT1 FGF2 FGF9 FGFR1 FGFR3
6 syringoma 29.6 S100B VIM
7 ewing sarcoma 28.8 CDKN1A FGF2 FGFR1 NES S100B TGFB2
8 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.0
9 exostoses, multiple, type i 11.9
10 carpotarsal osteochondromatosis 11.7
11 metachondromatosis 11.6
12 hereditary multiple exostoses 11.6
13 exostoses, multiple, type ii 11.4
14 exostoses, multiple, type iii 11.3
15 potocki-shaffer syndrome 11.0
16 exostosis 10.4
17 thrombosis 10.3
18 clear cell chondrosarcoma 10.3 EXT2 PTHLH
19 actinic cheilitis 10.3 CDKN1A FGFR3
20 multiple enchondromatosis, maffucci type 10.2 EXT1 EXT2
21 plagiocephaly 10.2 FGFR1 FGFR3
22 bursitis 10.2
23 osteoglophonic dysplasia 10.2 FGFR1 FGFR3
24 enchondromatosis, multiple, ollier type 10.2 EXT1 EXT2 PTHLH
25 extramedullary plasmacytoma 10.2 BCL2 CDKN1A
26 benign metastasizing leiomyoma 10.1 BCL2 VIM
27 crouzon syndrome 10.1 FGF2 FGFR1 FGFR3
28 hydromyelia 10.1 S100B VIM
29 lacrimoauriculodentodigital syndrome 10.1 FGF9 FGFR1 FGFR3
30 bednar tumor 10.1 S100B VIM
31 juxtacortical chondroma 10.1 EXT1 PTHLH
32 primary hepatic neuroendocrine carcinoma 10.1 S100B VIM
33 hemifacial hyperplasia 10.1
34 clear cell adenoma 10.1 PTHLH S100B
35 syringocystadenoma papilliferum 10.1 S100B VIM
36 ossifying fibromyxoid tumor 10.1 S100B VIM
37 bone disease 10.1 EXT1 EXT2 FGFR3 PTHLH
38 rosette-forming glioneuronal tumor 10.1 FGFR1 S100B
39 fibrous meningioma 10.1 S100B VIM
40 chordoid meningioma 10.1 S100B VIM
41 eccrine porocarcinoma 10.1 S100B VIM
42 ependymoblastoma 10.1 NES VIM
43 periosteal chondrosarcoma 10.1 EXT1 PTHLH
44 dysembryoplastic neuroepithelial tumor 10.1 NES S100B
45 myxopapillary ependymoma 10.1 S100B VIM
46 astroblastoma 10.1 NES VIM
47 monophasic synovial sarcoma 10.1 S100B VIM
48 head injury 10.1 BCL2 S100B
49 tooth ankylosis 10.0 BMP2 PTHLH
50 spiradenoma 10.0 S100B VIM

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.68 E2F1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.68 BMP2 E2F1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.68 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.68 BCL2 BMP2 CDKN1A E2F1 FGFR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.68 CDKN1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.68 BCL2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.68 BCL2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.68 E2F1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.68 FGFR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.68 CDKN1A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.68 FGFR1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.68 E2F1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.68 BMP2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.68 BCL2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.68 BCL2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.68 BCL2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.68 CDKN1A
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.68 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
2 behavior/neurological MP:0005386 10.36 BCL2 CDKN1A E2F1 EXT1 FGF2 FGF9
3 craniofacial MP:0005382 10.34 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
4 embryo MP:0005380 10.32 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
5 mortality/aging MP:0010768 10.32 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
6 cardiovascular system MP:0005385 10.31 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
7 growth/size/body region MP:0005378 10.31 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
8 homeostasis/metabolism MP:0005376 10.31 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
9 digestive/alimentary MP:0005381 10.29 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF9
10 hearing/vestibular/ear MP:0005377 10.26 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF2
11 hematopoietic system MP:0005397 10.25 BCL2 BMP2 CDKN1A E2F1 FGF2 FGFR1
12 immune system MP:0005387 10.22 BCL2 BMP2 CDKN1A E2F1 FGF9 FGFR1
13 endocrine/exocrine gland MP:0005379 10.18 BCL2 BMPR1B CDKN1A E2F1 FGF9 FGFR1
14 nervous system MP:0003631 10.18 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
15 integument MP:0010771 10.16 BCL2 CDKN1A E2F1 EXT1 FGF9 FGFR1
16 limbs/digits/tail MP:0005371 10.15 BMP2 BMPR1B CDKN1A EXT1 FGF9 FGFR1
17 muscle MP:0005369 10.06 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
18 reproductive system MP:0005389 10.03 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
19 normal MP:0002873 10.02 BMP2 BMPR1B E2F1 EXT1 FGF9 FGFR1
20 neoplasm MP:0002006 9.98 BCL2 CDKN1A E2F1 EXT1 FGF2 FGFR3
21 renal/urinary system MP:0005367 9.87 BCL2 CDKN1A FGF9 FGFR1 FGFR3 PTHLH
22 skeleton MP:0005390 9.73 BMP2 BMPR1B CDKN1A E2F1 EXT1 EXT2
23 respiratory system MP:0005388 9.7 CDKN1A E2F1 FGF9 FGFR3 PTHLH TGFB2
24 vision/eye MP:0005391 9.4 BCL2 BMPR1B CDKN1A E2F1 EXT1 FGF2

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Anti-Inflammatory Agents Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Narcotics Phase 4
11 Analgesics, Opioid Phase 4
12 Cyclooxygenase 2 Inhibitors Phase 4
13 Central Nervous System Depressants Phase 4
14 Analgesics Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Analgesics, Non-Narcotic Phase 4
17 Cyclooxygenase Inhibitors Phase 4
18 Antirheumatic Agents Phase 4
19 Hormone Antagonists Phase 4
20 Methylprednisolone acetate Phase 4
21 Prednisolone acetate Phase 4
22 Autonomic Agents Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Protective Agents Phase 4
25 Neuroprotective Agents Phase 4
26 Antiemetics Phase 4
27 Hormones Phase 4
28 Gastrointestinal Agents Phase 4
29 glucocorticoids Phase 4
30
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4 etoricoxib;tramadol
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Predicting Response to Intra-Articular Corticosteroid Injection in Patients With Osteoarthritis of the Glenohumeral Joint Recruiting NCT03232749 Phase 4 corticosteroid injections
5 Autologous Stem Cells in Achilles Tendinopathy Unknown status NCT02064062 Phase 2
6 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
7 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
8 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Unknown status NCT02934100 Not Applicable
9 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
10 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
11 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393 Not Applicable
12 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
13 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
14 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
15 Effect of Chosen Treatment Methods in Patients With Cervical Spine Osteoarthritis Completed NCT03683602 Not Applicable
16 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
17 Superior Capsule Reconstruction vs Partial Repair of Massive Rotator Cuff Tears Recruiting NCT03617562 Not Applicable
18 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
19 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Genetic tests related to Osteochondroma:

# Genetic test Affiliating Genes
1 Osteochondroma 29

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

41
Bone, Spinal Cord, Bone Marrow, Uterus, Lung, T Cells, B Cells

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 1029)
# Title Authors Year
1
Regression of a solitary osteochondroma of the distal humerus in a toddler following trauma. ( 30425771 )
2019
2
Osteochondroma of the Zygomatic Arch: A Case Report and Review of the Literature. ( 29684307 )
2018
3
A multidisciplinary approach for the treatment of young patients with suprasellar osteochondroma. ( 29067502 )
2018
4
Solitary anterior osteochondroma of cervical spine: An unusual cause of dysphagia and review of literature. ( 29928094 )
2018
5
Solitary facet joint osteochondroma of the upper thoracic spine: An unusual cause of cord compression in the pediatric age group. ( 29547195 )
2018
6
Solitary Osteochondroma of the Spine-A Case Series: Review of Solitary Osteochondroma With Myelopathic Symptoms. ( 29977716 )
2018
7
Osteochondroma of the Scapula with Accessory Nerve (XI) Compression. ( 29785314 )
2018
8
Rare Osteochondroma Associated with Natural Mortality of a Wild White-Tailed Deer ( Odocoileus virginianus). ( 29369726 )
2018
9
Occlusal adjustment after local resection of type 1 condylar osteochondroma. ( 29517694 )
2018
10
Osteochondroma of ventral scapula associated with chest pain due to rib cage compression: A case report. ( 29703017 )
2018
11
Ulnar Lengthening/Reconstruction of Interosseous Membrane in Treatment of Osteochondroma. ( 29576923 )
2018
12
Digital cutting guide and endoscopically-assisted vertical ramus osteotomy to treat condylar osteochondroma: a long-term study. ( 29895393 )
2018
13
Huge Bursitis and Bursal Synovial Osteochondromatosis associated with Scapular Osteochondroma Mimicking a Giant Calcific Mass of the Chest Wall: A Case Report. ( 29905601 )
2018
14
Solitary Osteochondroma of the Ventral Scapula Associated with Large Bursa Formation and Pseudowinging of the Scapula: A Case Report and Literature Review. ( 29666735 )
2018
15
Novel exostosin-2 mutation identified in a Chinese family with hereditary multiple osteochondroma. ( 29541207 )
2018
16
Scapular osteochondroma with winging: A case report. ( 29614444 )
2018
17
Multiple Hereditary Exostoses with Tetraparesis due to Cervical Spine Osteochondroma. ( 29783013 )
2018
18
Solitary osteochondroma of the capitate, in a child. ( 29628715 )
2018
19
Peripheral Osteochondroma of Buccal Mucosa. ( 29690980 )
2018
20
Insufficiency fracture at an osteochondroma bridging the proximal fibula and the tibia: Case report. ( 29881159 )
2018
21
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion. ( 29596896 )
2018
22
Incidental finding of pelvic osteochondroma. ( 29548897 )
2018
23
Huge Bursitis Associated With Scapular Osteochondroma Presenting as a Giant Mass of the Chest Wall: A Case Presentation. ( 29524608 )
2018
24
Proximal Tibial Osteochondroma Leading to Chronic Compartment Syndrome. ( 30173694 )
2018
25
Surgical Management of Onychopapilloma, Onychomatricoma, and Subungual Osteochondroma: Case Series. ( 30533990 )
2018
26
Solitary osteochondroma of the sinus tarsi. ( 28244886 )
2018
27
Comparison of the clinical effects of treatment of osteochondroma by two types of vertical ramus osteotomy. ( 28249702 )
2018
28
Post-traumatic osteochondroma of the distal femur. ( 29487657 )
2018
29
Solitary osteochondroma in the body of the pubic bone: a cadaveric case report. ( 29984059 )
2018
30
Patellar Osteochondroma: A Unique Presentation. ( 30084584 )
2018
31
Osteoblastic Osteosarcoma Arising beneath an Osteochondroma in an 11-Year-Old Male with Multiple Hereditary Exostoses. ( 30123601 )
2018
32
Treatment of spinal cord compression caused by C2 osteochondroma with reconstruction and fusion after total resection: Case report and literature review. ( 30207870 )
2018
33
A Rare Case of Tibioperoneal Arterial Trunk Entrapment Caused by a Fibular Osteochondroma. ( 30218831 )
2018
34
A rare case of osteochondroma of the coccyx. ( 30232956 )
2018
35
Large rib osteochondroma in a child in Aleppo, Syria. ( 30254734 )
2018
36
A pseudoaneurysm of the popliteal artery probably pierced by a bone spike arising in the spontaneously regressed osteochondroma: A case report. ( 30318426 )
2018
37
Osteochondroma of scapular body-trans-scapular technique of resection: a case report. ( 30340808 )
2018
38
Osteosarcoma in the coracoid process that mimicked an osteochondroma: A case report. ( 29145279 )
2017
39
Surgical Hip Dislocation for Management of Acetabular Osteochondroma in an Adult. ( 28811949 )
2017
40
Thoracic spinal osteochondroma: A rare presentation of spinal cord compression. ( 28577449 )
2017
41
Pediatric Trigger Finger due to Osteochondroma: A Report of Two Cases. ( 28082852 )
2017
42
Transpedicular excision of a thoracic intraspinal osteochondroma in a patient with Hereditary Multiple Exostoses and Brown-Sequard syndrome: a case report. ( 29258931 )
2017
43
Osteochondroma of the Hyoid: First Pediatric Case and Literature Review. ( 28728426 )
2017
44
Type IV popliteal arterial entrapment associated with an osteochondroma. ( 29349380 )
2017
45
Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses. ( 29120519 )
2017
46
Excision of Solitary Osteochondroma on the Ventral Aspect of Left Scapula Presenting as Pseudowinging in a 4-year-old Boy: A Rare Case Report. ( 28630837 )
2017
47
Isolated acetabular osteochondroma of the hip. ( 28869065 )
2017
48
Oldest epiphyseal osteochondroma in a subadult from Ancient Egypt. ( 28878530 )
2017
49
An Unusual Presentation of Osteochondroma in a Sexagenarian. ( 29375954 )
2017
50
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. ( 27777159 )
2017

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
2
Show member pathways
13.67 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
3
Show member pathways
13.49 BCL2 BMP2 CDKN1A FGF2 FGF9 FGFR1
4
Show member pathways
13.33 BCL2 CDKN1A FGF2 FGF9 FGFR1 FGFR3
5
Show member pathways
13.33 BCL2 BMP2 BMPR1B CDKN1A FGF2 FGFR1
6
Show member pathways
13.25 BCL2 BMP2 BMPR1B FGF2 FGFR1 FGFR3
7
Show member pathways
13.24 BMP2 FGF2 FGFR1 FGFR3 TGFB2 VIM
8
Show member pathways
12.9 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
9
Show member pathways
12.84 BCL2 CDKN1A E2F1 FGFR1 TGFB2
10 12.74 FGF2 FGF9 FGFR1 FGFR3 TGFB2
11
Show member pathways
12.7 CDKN1A FGF2 FGF9 FGFR1 FGFR3
12
Show member pathways
12.67 BMP2 FGF2 FGFR1 FGFR3 TGFB2
13 12.58 FGF2 FGF9 FGFR1 FGFR3
14
Show member pathways
12.58 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
15
Show member pathways
12.54 FGF2 FGF9 FGFR1 FGFR3
16
Show member pathways
12.53 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
17
Show member pathways
12.49 EXT1 EXT2 FGFR1 PTHLH
18
Show member pathways
12.42 FGF2 FGF9 FGFR1 FGFR3
19
Show member pathways
12.42 BCL2 BMPR1B FGFR1 FGFR3
20
Show member pathways
12.41 BMP2 BMPR1B E2F1 FGF2 TGFB2
21
Show member pathways
12.39 FGF2 FGF9 FGFR1 FGFR3
22
Show member pathways
12.38 BMP2 FGF2 FGFR1 FGFR3 TGFB2
23
Show member pathways
12.37 FGF2 FGF9 FGFR1 FGFR3
24 12.36 BCL2 CDKN1A E2F1 FGFR3 TGFB2 VIM
25 12.33 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
26 12.28 BCL2 CDKN1A E2F1 VIM
27 12.27 CDKN1A FGF2 FGFR1 TGFB2
28
Show member pathways
12.25 FGF2 FGF9 FGFR1 FGFR3
29
Show member pathways
12.21 BMP2 FGF2 FGFR1 FGFR3 TGFB2
30
Show member pathways
12.12 FGF2 FGF9 FGFR1 FGFR3
31
Show member pathways
12.12 BCL2 CDKN1A E2F1 FGFR1 FGFR3
32 12.05 BCL2 CDKN1A E2F1 FGFR1 FGFR3
33 12.04 BMPR1B FGF2 FGFR1 FGFR3
34 11.96 BCL2 BMP2 CDKN1A E2F1 TGFB2
35 11.93 BCL2 CDKN1A FGF2 VIM
36 11.89 FGF2 FGFR1 FGFR3
37 11.88 BCL2 CDKN1A FGFR1 PTHLH
38 11.87 BCL2 BMP2 CDKN1A E2F1
39 11.85 BCL2 CDKN1A E2F1
40
Show member pathways
11.83 FGF2 FGF9 FGFR1
41
Show member pathways
11.81 BCL2 BMP2 CDKN1A FGF2 FGFR1 FGFR3
42 11.8 BMP2 BMPR1B TGFB2
43 11.77 FGF2 FGFR1 FGFR3 TGFB2
44 11.72 CDKN1A E2F1 FGFR3
45 11.68 BMP2 FGF2 FGFR1 FGFR3 TGFB2
46
Show member pathways
11.61 FGF2 FGF9 FGFR3
47 11.59 BCL2 BMP2 CDKN1A E2F1 TGFB2
48 11.5 FGF2 FGFR1 TGFB2
49 11.47 BCL2 CDKN1A E2F1
50 11.42 FGF2 FGFR1 FGFR3

GO Terms for Osteochondroma

Cellular components related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 BMP2 FGF2 FGF9 FGFR1 FGFR3 PTHLH

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 BCL2 CDKN1A FGF2 VIM
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 BMP2 FGF2 FGFR1 FGFR3
3 angiogenesis GO:0001525 9.94 FGF2 FGF9 FGFR1 TGFB2
4 MAPK cascade GO:0000165 9.92 FGF2 FGF9 FGFR1 FGFR3
5 cellular response to hypoxia GO:0071456 9.88 BCL2 E2F1 S100B
6 negative regulation of cell growth GO:0030308 9.88 BCL2 CDKN1A TGFB2
7 animal organ morphogenesis GO:0009887 9.88 BCL2 BMP2 FGF2
8 peptidyl-tyrosine phosphorylation GO:0018108 9.88 FGF2 FGF9 FGFR1 FGFR3
9 positive regulation of protein kinase B signaling GO:0051897 9.88 FGF2 FGF9 FGFR1 FGFR3
10 male gonad development GO:0008584 9.86 BCL2 FGF9 TGFB2
11 cell-cell signaling GO:0007267 9.8 BMP2 FGF9 FGFR3 PTHLH TGFB2
12 response to glucocorticoid GO:0051384 9.79 BCL2 CDKN1A S100B
13 SMAD protein signal transduction GO:0060395 9.78 BMP2 TGFB2 VIM
14 phosphatidylinositol phosphorylation GO:0046854 9.78 FGF2 FGF9 FGFR1 FGFR3
15 embryonic limb morphogenesis GO:0030326 9.77 FGF9 FGFR1 TGFB2
16 positive regulation of cell proliferation GO:0008284 9.76 BCL2 FGF2 FGF9 FGFR1 FGFR3 PTHLH
17 positive regulation of cell division GO:0051781 9.74 FGF2 FGF9 TGFB2
18 branching involved in ureteric bud morphogenesis GO:0001658 9.73 BCL2 BMP2 FGF2
19 ossification GO:0001503 9.73 BCL2 BMP2 EXT1 EXT2
20 bone mineralization GO:0030282 9.71 BMP2 FGFR3 PTHLH
21 embryonic digestive tract development GO:0048566 9.7 FGF9 TGFB2
22 endocardial cushion morphogenesis GO:0003203 9.7 BMP2 TGFB2
23 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.7 EXT1 EXT2
24 positive regulation of cardiac muscle cell proliferation GO:0060045 9.7 FGF2 FGF9 FGFR1
25 positive regulation of cartilage development GO:0061036 9.69 BMP2 BMPR1B
26 ear development GO:0043583 9.69 BCL2 FGFR1
27 eye development GO:0001654 9.69 BMPR1B FGF9 TGFB2
28 positive regulation of ossification GO:0045778 9.68 BMP2 TGFB2
29 cardiac epithelial to mesenchymal transition GO:0060317 9.68 BMP2 TGFB2
30 generation of neurons GO:0048699 9.67 FGFR1 TGFB2
31 pathway-restricted SMAD protein phosphorylation GO:0060389 9.67 BMP2 TGFB2
32 positive regulation of phospholipase C activity GO:0010863 9.67 FGF2 FGFR1
33 fibroblast growth factor receptor signaling pathway GO:0008543 9.67 FGF2 FGF9 FGFR1 FGFR3
34 atrioventricular valve morphogenesis GO:0003181 9.66 BMP2 TGFB2
35 mesenchymal cell differentiation GO:0048762 9.66 BMP2 FGFR1
36 salivary gland morphogenesis GO:0007435 9.65 FGFR1 TGFB2
37 stem cell proliferation GO:0072089 9.65 FGF2 NES
38 positive regulation of MAPK cascade GO:0043410 9.65 BMP2 DUSP19 FGF9 FGFR1 FGFR3
39 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.64 EXT1 EXT2
40 lung-associated mesenchyme development GO:0060484 9.63 FGF9 FGFR1
41 positive regulation of phospholipase activity GO:0010518 9.63 FGFR1 FGFR3
42 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.62 FGF2 FGF9 FGFR1 FGFR3
43 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.55 FGF2 FGFR1
44 cellular polysaccharide biosynthetic process GO:0033692 9.46 EXT1 EXT2
45 chondrocyte differentiation GO:0002062 9.35 BMP2 BMPR1B FGF9 FGFR1 FGFR3
46 skeletal system development GO:0001501 9.17 BMP2 BMPR1B EXT1 FGFR1 FGFR3 PTHLH
47 protein phosphorylation GO:0006468 10.09 BMP2 BMPR1B FGFR1 FGFR3 TGFB2
48 cell differentiation GO:0030154 10.04 BMP2 BMPR1B EXT2 FGF2 FGF9 FGFR1
49 regulation of signaling receptor activity GO:0010469 10.01 BMP2 FGF2 FGF9 PTHLH TGFB2
50 negative regulation of cell proliferation GO:0008285 10 BCL2 BMP2 CDKN1A PTHLH TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.97 BCL2 EXT1 EXT2 FGFR1 S100B TGFB2
2 protein heterodimerization activity GO:0046982 9.91 BCL2 BMP2 EXT1 EXT2 TGFB2
3 growth factor activity GO:0008083 9.76 BMP2 FGF2 FGF9 TGFB2
4 protein tyrosine kinase activity GO:0004713 9.73 FGF2 FGF9 FGFR1 FGFR3
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.56 FGF2 FGF9 FGFR1 FGFR3
6 fibroblast growth factor-activated receptor activity GO:0005007 9.48 FGFR1 FGFR3
7 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.4 EXT1 EXT2
8 receptor-receptor interaction GO:0090722 9.37 FGF2 FGFR1
9 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.32 EXT1 EXT2
10 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF2 FGF9 FGFR1 FGFR3
11 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.16 EXT1 EXT2
12 1-phosphatidylinositol-3-kinase activity GO:0016303 8.92 FGF2 FGF9 FGFR1 FGFR3

Sources for Osteochondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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