MCID: OST028
MIFTS: 44

Osteochondroma

Categories: Bone diseases, Cancer diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Osteochondroma

MalaCards integrated aliases for Osteochondroma:

Name: Osteochondroma 20 54 17
Cartilaginous Exostosis 70

Classifications:



External Ids:

UMLS 70 C0029423

Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to metachondromatosis and hereditary multiple osteochondromas. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drug Tretinoin has been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Osteochondromas are the most common benign tumors of the bones. The tumors take the form of... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 metachondromatosis 31.9 PTHLH EXT2 EXT1
2 hereditary multiple osteochondromas 31.5 EXT2 EXT1
3 exostosis 31.1 EXT2 EXT1 BMP2
4 dysplasia epiphysealis hemimelica 30.8 EXT2 EXT1
5 juxtacortical chondroma 30.3 EXT2 EXT1
6 fgfr craniosynostosis syndromes 30.1 FGFR3 FGFR1
7 synovial chondromatosis 30.0 FGFR3 FGFR1 FGF9 FGF2 BMP2
8 periosteal chondrosarcoma 29.9 NCOA2 EXT1
9 osteogenic sarcoma 29.9 PTHLH E2F1 CDKN1A BMP2
10 chondroblastoma 29.9 PTHLH FGFR3 FGFR1
11 muenke syndrome 29.8 FGFR3 FGFR1 FGF9
12 spindle cell sarcoma 29.8 VIM S100B NCOA2
13 mesenchymal chondrosarcoma 29.8 VIM NCOA2 HEY1
14 neurofibroma 29.7 VIM S100B ERBB2
15 sarcoma, synovial 29.7 VIM S100B NES BCL2
16 neuroma 29.6 S100B FGFR1 FGF2
17 neuroblastoma 29.5 NES FGFR3 FGFR1 FGF2 ERBB2 CDKN1A
18 neurilemmoma 29.4 VIM S100B NES
19 diffuse idiopathic skeletal hyperostosis 29.4 FGF2 ERBB2 BMP2
20 chondrosarcoma 29.4 VIM S100B PTHLH NCOA2 FGFR3 FGF2
21 chromosome 2q35 duplication syndrome 29.2 FGFR3 FGFR1 BMPR1B BMP2
22 sarcoma 28.8 VIM S100B FGFR3 FGFR1 FGF2 E2F1
23 osteochondrodysplasia 28.7 PTHLH FGFR3 FGFR1 FGF9 FGF2 EXT2
24 medulloblastoma 28.0 VIM S100B NES FGFR1 FGF2 ERBB2
25 tolchin-le caignec syndrome 11.1
26 hereditary multiple exostoses 10.6
27 exostoses, multiple, type i 10.4
28 chondroma 10.4
29 ankylosing spondylitis 3 10.4 EXT2 EXT1
30 exostoses, multiple, type ii 10.4
31 frozen shoulder 10.4
32 bursitis 10.4
33 actinic cheilitis 10.4 FGFR3 CDKN1A
34 breast juvenile papillomatosis 10.3 FGFR3 ERBB2
35 multiple enchondromatosis, maffucci type 10.3 PTHLH EXT2 EXT1
36 enchondromatosis, multiple, ollier type 10.3 PTHLH EXT2 EXT1
37 radiculopathy 10.3
38 plagiocephaly 10.3 FGFR3 FGFR1
39 parietal foramina 10.3 FGFR3 EXT2 BMPR1B
40 syndromic craniosynostosis 10.2 FGFR3 FGFR1
41 choriocarcinoma of ovary 10.2 NCOA2 HEY1
42 spinal canal intradural extramedullary neoplasm 10.2 NCOA2 HEY1
43 head injury 10.2 S100B BCL2
44 deafness, autosomal recessive 71 10.2 FGFR3 FGFR1 FGF9
45 thrombosis 10.2
46 ankylosis 10.2
47 benign metastasizing leiomyoma 10.2 VIM BCL2
48 synostoses, tarsal, carpal, and digital 10.2 FGF9 BMPR1B
49 suppressor of tumorigenicity 3 10.2 CDKN1A BCL2
50 hypertelorism, microtia, facial clefting syndrome 10.2 FGFR3 FGFR1

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-107 9.47 TGFB2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.47 BCL2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 9.47 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-133 9.47 TGFB2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 BCL2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.47 TGFB2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.47 BCL2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.47 BCL2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-199 9.47 BCL2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.47 TGFB2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.47 TGFB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.47 TGFB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.47 BCL2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.47 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.48 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
2 behavior/neurological MP:0005386 10.4 BCL2 CDKN1A E2F1 ERBB2 EXT1 FGF2
3 cardiovascular system MP:0005385 10.4 BCL2 BMP2 CDKN1A E2F1 ERBB2 FGF2
4 embryo MP:0005380 10.39 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
5 mortality/aging MP:0010768 10.39 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
6 craniofacial MP:0005382 10.38 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
7 growth/size/body region MP:0005378 10.37 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
8 digestive/alimentary MP:0005381 10.3 BCL2 BMP2 CDKN1A E2F1 ERBB2 EXT1
9 endocrine/exocrine gland MP:0005379 10.24 BCL2 BMPR1B CDKN1A E2F1 ERBB2 FGF9
10 integument MP:0010771 10.24 BCL2 CDKN1A E2F1 ERBB2 EXT1 FGF9
11 hearing/vestibular/ear MP:0005377 10.21 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF2
12 nervous system MP:0003631 10.21 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
13 limbs/digits/tail MP:0005371 10.18 BMP2 BMPR1B CDKN1A ERBB2 EXT1 FGF9
14 muscle MP:0005369 10.13 BCL2 CDKN1A E2F1 ERBB2 FGF2 FGF9
15 normal MP:0002873 10.1 BMP2 BMPR1B E2F1 ERBB2 EXT1 FGF9
16 reproductive system MP:0005389 10.1 BCL2 BMP2 BMPR1B CDKN1A E2F1 ERBB2
17 neoplasm MP:0002006 10.01 BCL2 CDKN1A E2F1 ERBB2 EXT1 FGF2
18 skeleton MP:0005390 9.77 BMP2 BMPR1B CDKN1A E2F1 ERBB2 EXT1
19 respiratory system MP:0005388 9.76 CDKN1A E2F1 ERBB2 FGF9 FGFR3 PTHLH
20 vision/eye MP:0005391 9.4 BCL2 BMPR1B CDKN1A E2F1 EXT1 FGF2

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Palovarotene in Subjects With Multiple Osteochondromas Terminated NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
2 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
3 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
4 Registry of Multiple Osteochondromas That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Quality of Life Data. Data Are Linked to Patients Biological Sample Enrolling by invitation NCT04133285
5 Genotype-Phenotype Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
6 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

40
Bone, Spinal Cord, Pituitary, Tongue, Thyroid, Breast, Bone Marrow

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 2212)
# Title Authors PMID Year
1
Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones. 61 54
17490719 2007
2
Soft tissue osteochondroma: case report and immunohistochemistry for parathyroid hormone-related protein. 54 61
16844564 2006
3
Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients. 61 54
16476576 2006
4
Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. 54 61
16026543 2005
5
Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma. 54 61
15796962 2005
6
The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting. 54 61
15744499 2005
7
Immunohistochemical study of chondrolipoma: possible importance of transforming growth factor (TGF)-betas, latent TGF-beta binding protein-1 (LTBP-1), and bone morphogenetic protein (BMP) for chondrogenesis in lipoma. 61 54
12692354 2003
8
The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. 61 54
12645631 2003
9
Cytogenetic and molecular cytogenetic evidence of recurrent 8q24.1 loss in osteochondroma. 54 61
12393280 2002
10
Hereditary multiple exostoses: one center's experience and review of etiology. 54 61
12151882 2002
11
[From gene to disease; hereditary multiple exostoses]. 54 61
11845565 2002
12
Ext-mutation analysis in Italian sporadic and hereditary osteochondromas. 61 54
11668521 2001
13
Involvement of BMP-2 signaling in a cartilage cap in osteochondroma. 61 54
11781009 2001
14
Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. 61 54
11140704 2000
15
Expression of cell cycle-associated proteins CDK4, p27, and E2F-1 in chondrosarcoma of the jaws. 54 61
11314534 2000
16
EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. 54 61
10441575 1999
17
The neoplastic pathogenesis of solitary and multiple osteochondromas. 61 54
10398153 1999
18
Clonal karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas. 54 61
9576285 1998
19
Selective increase in expression of isoform PP1 gamma 1 of type-1 protein phosphatase in chondrosarcoma cells. 61 54
7712113 1994
20
Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-mediated PI3K-Akt signalling pathway. 61
33797312 2021
21
Effect of condylar osteochondroma resection through an intraoral approach on the masticatory functions: a preliminary evaluation based on occlusion and temporomandibular joint functions. 61
33589310 2021
22
Multiple Osteochondromas Comorbid With Enlarged Parietal Foramina, Elongated Styloid Processes, and Tibiofibular Synostosis. 61
33769443 2021
23
Chondrogenic Bone Tumors: The Importance of Imaging Characteristics. 61
33152784 2021
24
Differential Diagnosis of Facet Joint Disorders. 61
33481690 2021
25
Rib osteochondroma causing cardiac compression in a pediatric patient. 61
33743258 2021
26
Osteochondromas: An Updated Review of Epidemiology, Pathogenesis, Clinical Presentation, Radiological Features and Treatment Options. 61
33622860 2021
27
Diagnosis, Management, and Treatment Options: A Cervical Spine Osteochondroma Meta-Analysis. 61
33561553 2021
28
Dysplasia epiphysealis hemimelica of the radial head: a rare case report. 61
33546632 2021
29
Rituximab as a treatment option in a patient with rheumatoid arthritis and a history of malignancy-intracranial chondrosarcoma/osteochondroma-case based review. 61
33001390 2021
30
Chondrosarcoma. 61
33595238 2021
31
Rib Osteoblastoma as a Cause of Neurogenic Thoracic Outlet Syndrome: A Case Report. 61
33556044 2021
32
Lumbar Myelopathy Caused by Multiple Cartilaginous Exostoses in a Dog. 61
33631383 2021
33
Surgical treatment of osteochondroma on the first rib by double clavicle osteotomy and internal fixation with a reconstruction plate: A case report and literature review. 61
33482445 2021
34
Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis. 61
33500396 2021
35
Bizarre parosteal osteochondromatous proliferation: Rare case affecting distal ulna and review of literature. 61
32977195 2021
36
Peroneal Nerve Function Before and Following Surgical Excision of a Proximal Fibular Osteochondroma. 61
33003067 2021
37
Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging. 61
33144905 2021
38
Osteochondroma of the pubic symphysis causing hematuria: a case report and literature review. 61
33407372 2021
39
A new method for individual condylar osteotomy and repositioning guides used in patients with severe deformity secondary to condylar osteochondroma. 61
33516245 2021
40
Solitary osteochondroma in the pisiform bone with pisotriquetal osteoarthritis. A case study. 61
32605850 2021
41
Management of deformity inducing osteochondroma of the temporomandibular joint: a case report. 61
33450089 2021
42
Solitary thoracic osteochondroma causing spinal compression: Case report. 61
33650517 2021
43
Treatment of spinal cord compression caused by C2 osteochondroma with reconstruction and fusion after total resection: Case report and literature review. 61
30207870 2021
44
Simultaneous Condylar Reconstruction by Free Ramus Osteotomy Graft After Complete Condylectomy for Osteochondroma. 61
33481470 2021
45
Paleopathological study of a podal osteochondroma from the prehistoric Hypogeum of Calaforno (Sicily). 61
32281156 2021
46
Osteochondroma of the talus: three varying cases. 61
33370985 2020
47
Generation of an induced pluripotent stem cell line SMBCi010-A from a male with Multiple Osteochondroma carrying a EXT1 mutation. 61
33360848 2020
48
Osteochondroma of the proximal phalanx of toe presenting as widening of third web space- a rare case report. 61
33214074 2020
49
Osteochondroma of the distal tibia in an 8-year-old child: Do we need to excise a benign tumor? 61
33363997 2020
50
Popliteal artery entrapment syndrome secondary to a femoral osteochondroma. 61
33480009 2020

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.19 S100B PTHLH NCOA2 HEY1 FGFR3 FGFR1
2
Show member pathways
13.75 VIM TGFB2 FGFR3 FGFR1 FGF2 ERBB2
3
Show member pathways
13.57 TGFB2 NCOA2 FGFR3 FGFR1 FGF9 FGF2
4
Show member pathways
13.54 TGFB2 FGFR3 FGFR1 FGF9 FGF2 ERBB2
5
Show member pathways
13.36 VIM FGFR3 FGFR1 FGF9 FGF2 ERBB2
6
Show member pathways
13.35 TGFB2 FGFR3 FGFR1 FGF2 ERBB2 CDKN1A
7
Show member pathways
13.28 VIM TGFB2 FGFR3 FGFR1 FGF2 ERBB2
8
Show member pathways
13.27 TGFB2 FGFR3 FGFR1 FGF2 ERBB2 BMPR1B
9
Show member pathways
13.12 FGFR3 FGFR1 FGF9 FGF2 ERBB2 CDKN1A
10
Show member pathways
12.8 TGFB2 FGFR1 ERBB2 E2F1 CDKN1A BCL2
11
Show member pathways
12.75 HEY1 FGFR3 FGFR1 FGF9 FGF2 ERBB2
12 12.74 TGFB2 FGFR3 FGFR1 FGF9 FGF2 ERBB2
13
Show member pathways
12.71 TGFB2 FGFR3 FGFR1 FGF2 BMP2
14
Show member pathways
12.69 FGFR3 FGFR1 FGF9 FGF2 ERBB2 CDKN1A
15
Show member pathways
12.58 FGFR1 FGF9 FGF2 ERBB2 E2F1 CDKN1A
16
Show member pathways
12.5 FGFR3 FGF2 ERBB2 CDKN1A BCL2
17
Show member pathways
12.48 TGFB2 FGF2 E2F1 BMPR1B BMP2
18
Show member pathways
12.48 TGFB2 HEY1 FGFR1 FGF9 FGF2 ERBB2
19
Show member pathways
12.44 FGFR3 FGFR1 ERBB2 BMPR1B BCL2
20
Show member pathways
12.41 FGFR3 FGFR1 FGF9 FGF2
21
Show member pathways
12.41 FGFR3 FGFR1 FGF9 FGF2
22 12.4 VIM TGFB2 FGFR3 ERBB2 E2F1 CDKN1A
23
Show member pathways
12.39 FGFR3 FGFR1 FGF9 FGF2
24
Show member pathways
12.38 TGFB2 FGFR3 FGFR1 FGF2 ERBB2 BMP2
25 12.36 FGFR3 FGFR1 FGF9 FGF2 ERBB2
26
Show member pathways
12.32 NCOA2 ERBB2 CDKN1A BMP2
27
Show member pathways
12.28 FGFR3 FGFR1 FGF9 FGF2
28
Show member pathways
12.27 TGFB2 FGFR3 FGFR1 FGF2 BMP2
29 12.27 TGFB2 FGFR1 FGF2 ERBB2 CDKN1A
30
Show member pathways
12.18 FGFR3 FGFR1 FGF9 FGF2
31
Show member pathways
12.14 FGFR3 FGFR1 ERBB2 E2F1 CDKN1A BCL2
32 12.13 FGFR3 FGFR1 FGF2 ERBB2
33 12.11 FGFR3 FGFR1 FGF2 BMPR1B
34 12.09 TGFB2 HEY1 FGFR3 FGFR1 FGF9 FGF2
35 12.08 NCOA2 E2F1 CDKN1A BMP2
36 11.99 VIM FGF2 CDKN1A BCL2
37 11.94 E2F1 CDKN1A BMP2 BCL2
38 11.94 PTHLH FGFR1 CDKN1A BCL2
39 11.88 TGFB2 FGF2 BMP2
40 11.87 TGFB2 BMPR1B BMP2
41 11.86 E2F1 CDKN1A BCL2
42
Show member pathways
11.85 FGFR1 FGF9 FGF2
43 11.82 TGFB2 FGFR3 FGFR1 FGF2
44 11.75 ERBB2 CDKN1A BCL2
45 11.73 FGFR3 FGFR1 ERBB2
46 11.69 FGFR3 ERBB2 E2F1 CDKN1A
47 11.66 ERBB2 CDKN1A BCL2
48 11.66 TGFB2 FGFR3 FGFR1 FGF2 ERBB2 BMP2
49 11.64 TGFB2 E2F1 CDKN1A BMP2 BCL2
50
Show member pathways
11.63 FGFR3 FGF9 FGF2

GO Terms for Osteochondroma

Cellular components related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 VIM S100B PTHLH NES NCOA2 HEY1
2 receptor complex GO:0043235 9.26 FGFR3 FGFR1 ERBB2 BMPR1B

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.13 NES HEY1 FGFR3 FGFR1 FGF9 FGF2
2 protein phosphorylation GO:0006468 10.08 TGFB2 FGFR3 FGFR1 ERBB2 BMPR1B BMP2
3 negative regulation of cell proliferation GO:0008285 10.06 TGFB2 PTHLH CDKN1A BMP2 BCL2
4 heart development GO:0007507 9.99 TGFB2 ERBB2 CDKN1A BMP2
5 cell-cell signaling GO:0007267 9.98 PTHLH FGFR3 FGF9 BMP2
6 positive regulation of gene expression GO:0010628 9.98 VIM HEY1 FGF9 FGF2 ERBB2 E2F1
7 positive regulation of protein phosphorylation GO:0001934 9.96 FGF9 FGF2 ERBB2 BMP2
8 MAPK cascade GO:0000165 9.95 FGFR3 FGFR1 FGF9 FGF2 ERBB2
9 animal organ morphogenesis GO:0009887 9.93 FGF9 FGF2 BMP2 BCL2
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.89 TGFB2 FGFR1 FGF2
11 positive regulation of protein kinase B signaling GO:0051897 9.88 FGFR3 FGFR1 FGF9 FGF2 ERBB2
12 cell morphogenesis GO:0000902 9.87 TGFB2 EXT1 BCL2
13 positive regulation of cell growth GO:0030307 9.87 TGFB2 ERBB2 BCL2
14 positive regulation of kinase activity GO:0033674 9.85 FGFR3 FGFR1 ERBB2
15 cellular response to growth factor stimulus GO:0071363 9.84 ERBB2 BMPR1B BMP2
16 ossification GO:0001503 9.84 EXT2 EXT1 BMP2 BCL2
17 SMAD protein signal transduction GO:0060395 9.83 VIM TGFB2 BMP2
18 positive regulation of epithelial cell proliferation GO:0050679 9.82 FGF9 FGF2 ERBB2
19 positive regulation of MAP kinase activity GO:0043406 9.82 FGFR1 FGF2 ERBB2
20 BMP signaling pathway GO:0030509 9.81 TGFB2 EXT1 BMPR1B BMP2
21 positive regulation of cell proliferation GO:0008284 9.81 TGFB2 S100B PTHLH FGFR3 FGFR1 FGF9
22 positive regulation of cell division GO:0051781 9.8 TGFB2 FGF9 FGF2
23 positive regulation of cell differentiation GO:0045597 9.8 FGFR1 BMPR1B BMP2
24 bone mineralization GO:0030282 9.79 PTHLH FGFR3 BMP2
25 epithelial to mesenchymal transition GO:0001837 9.79 TGFB2 FGFR1 BMP2
26 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.77 TGFB2 FGF2 BMP2
27 wound healing GO:0042060 9.77 TGFB2 FGF2 EXT1 ERBB2 CDKN1A
28 branching involved in ureteric bud morphogenesis GO:0001658 9.76 FGF2 BMP2 BCL2
29 cellular response to BMP stimulus GO:0071773 9.75 EXT1 BMPR1B BMP2
30 pulmonary valve morphogenesis GO:0003184 9.71 TGFB2 HEY1
31 pathway-restricted SMAD protein phosphorylation GO:0060389 9.71 TGFB2 BMP2
32 chondrocyte proliferation GO:0035988 9.71 FGFR3 EXT1
33 chondrocyte differentiation GO:0002062 9.71 FGFR3 EXT1 BMPR1B BMP2
34 positive regulation of phospholipase C activity GO:0010863 9.7 FGFR1 FGF2
35 atrioventricular valve morphogenesis GO:0003181 9.7 TGFB2 BMP2
36 heparin biosynthetic process GO:0030210 9.7 EXT2 EXT1
37 multicellular organismal water homeostasis GO:0050891 9.69 EXT2 EXT1
38 cranial skeletal system development GO:1904888 9.68 TGFB2 EXT1
39 stem cell proliferation GO:0072089 9.68 NES FGF2
40 positive regulation of phospholipase activity GO:0010518 9.67 FGFR3 FGFR1
41 endochondral bone growth GO:0003416 9.67 FGFR3 EXT1
42 endocardial cushion morphogenesis GO:0003203 9.67 TGFB2 HEY1 BMP2
43 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.66 EXT2 EXT1
44 fibroblast growth factor receptor signaling pathway GO:0008543 9.65 FGFR3 FGFR1 FGF9 FGF2 EXT1
45 mesenchyme development GO:0060485 9.64 EXT1 BMP2
46 cardiac epithelial to mesenchymal transition GO:0060317 9.63 TGFB2 HEY1 BMP2
47 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.6 FGFR1 FGF2
48 fluid transport GO:0042044 9.57 EXT2 EXT1
49 cellular polysaccharide biosynthetic process GO:0033692 9.56 EXT2 EXT1
50 endochondral bone morphogenesis GO:0060350 9.5 EXT2 EXT1 BMPR1B

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.88 TGFB2 S100B FGFR1 EXT2 EXT1 BCL2
2 growth factor activity GO:0008083 9.62 TGFB2 FGF9 FGF2 BMP2
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.61 FGFR3 FGFR1 ERBB2
4 fibroblast growth factor-activated receptor activity GO:0005007 9.37 FGFR3 FGFR1
5 receptor-receptor interaction GO:0090722 9.26 FGFR1 FGF2
6 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.16 EXT2 EXT1
7 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.96 EXT2 EXT1
8 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 8.62 EXT2 EXT1

Sources for Osteochondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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