MCID: OST028
MIFTS: 51

Osteochondroma

Categories: Rare diseases, Bone diseases, Genetic diseases

Aliases & Classifications for Osteochondroma

MalaCards integrated aliases for Osteochondroma:

Name: Osteochondroma 53 29 55
Cartilaginous Exostosis 73

Classifications:



External Ids:

UMLS 73 C0029423

Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and exostoses, multiple, type i. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Etoricoxib and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 hereditary multiple osteochondromas 34.9 EXT1 EXT2
2 exostoses, multiple, type i 34.0 EXT1 EXT2
3 dysplasia epiphysealis hemimelica 31.4 EXT1 EXT2
4 chondrosarcoma 30.8 EXT1 EXT2 FGF2 PTHLH
5 chondroblastoma 30.2 FGFR1 FGFR3 PTHLH
6 muenke syndrome 29.5 EXT1 FGF2 FGF9 FGFR1 FGFR3
7 synovial chondromatosis 28.9 BMP2 FGF2 FGF9 FGFR1 FGFR3
8 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 11.9
9 carpotarsal osteochondromatosis 11.6
10 metachondromatosis 11.5
11 hereditary multiple exostoses 11.5
12 exostoses, multiple, type ii 11.2
13 exostoses, multiple, type iii 11.1
14 potocki-shaffer syndrome 10.9
15 clear cell chondrosarcoma 10.8 EXT2 PTHLH
16 plagiocephaly 10.8 FGFR1 FGFR3
17 osteoglophonic dysplasia 10.7 FGFR1 FGFR3
18 multiple enchondromatosis, maffucci type 10.7 EXT1 EXT2
19 enchondromatosis, multiple, ollier type 10.7 EXT1 EXT2 PTHLH
20 dysembryoplastic neuroepithelial tumor 10.6 NES S100B
21 rosette-forming glioneuronal tumor 10.5 FGFR1 S100B
22 hydromyelia 10.5 S100B VIM
23 bednar tumor 10.5 S100B VIM
24 lacrimoauriculodentodigital syndrome 10.5 FGF9 FGFR1 FGFR3
25 primary hepatic neuroendocrine carcinoma 10.5 S100B VIM
26 clear cell adenoma 10.5 PTHLH S100B
27 ossifying fibromyxoid tumor 10.5 S100B VIM
28 fibrous meningioma 10.5 S100B VIM
29 chordoid meningioma 10.4 S100B VIM
30 syringocystadenoma papilliferum 10.4 S100B VIM
31 eccrine porocarcinoma 10.4 S100B VIM
32 crouzon syndrome 10.4 FGF2 FGFR1 FGFR3
33 cervicitis 10.4
34 bone disease 10.4 EXT1 EXT2 FGFR3 PTHLH
35 benign metastasizing leiomyoma 10.3 BCL2 VIM
36 ependymoblastoma 10.3 NES VIM
37 pilocytic astrocytoma 10.3 FGF2 FGFR1 S100B
38 myxopapillary ependymoma 10.3 S100B VIM
39 optic nerve glioma 10.3 NES S100B VIM
40 neurilemmoma 10.2 NES S100B VIM
41 exostosis 10.2
42 ependymoma 10.2 NES S100B VIM
43 dermatofibrosarcoma protuberans 10.2 NES S100B VIM
44 monophasic synovial sarcoma 10.2 S100B VIM
45 head injury 10.2 BCL2 S100B
46 lung squamous cell carcinoma 10.2 FGF9 FGFR1 FGFR3 PTHLH
47 hidradenocarcinoma 10.2 BCL2 S100B VIM
48 apert syndrome 10.2 FGF2 FGF9 FGFR1 FGFR3
49 astroblastoma 10.2 NES VIM
50 thrombosis 10.1

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.64 E2F1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.64 BCL2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.64 BCL2 BMP2 CDKN1A E2F1 FGFR1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.64 CDKN1A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.64 BCL2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.64 BCL2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.64 E2F1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.64 FGFR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.64 CDKN1A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.64 FGFR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.64 E2F1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.64 BMP2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.64 BCL2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.64 BCL2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.64 BCL2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.64 CDKN1A
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.64 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 VIM EXT1 E2F1 BMP2 CDKN1A BCL2
2 behavior/neurological MP:0005386 10.35 VIM EXT1 E2F1 CDKN1A BCL2 FGFR1
3 craniofacial MP:0005382 10.33 E2F1 EXT1 BCL2 BMPR1B CDKN1A BMP2
4 embryo MP:0005380 10.32 VIM E2F1 EXT2 EXT1 BMP2 CDKN1A
5 cardiovascular system MP:0005385 10.3 VIM E2F1 CDKN1A BMP2 BCL2 FGFR1
6 growth/size/body region MP:0005378 10.3 EXT1 E2F1 CDKN1A BMP2 BCL2 BMPR1B
7 homeostasis/metabolism MP:0005376 10.3 VIM E2F1 CDKN1A BMP2 BCL2 FGFR1
8 mortality/aging MP:0010768 10.3 VIM EXT1 E2F1 EXT2 CDKN1A BMP2
9 digestive/alimentary MP:0005381 10.28 E2F1 EXT1 BMP2 CDKN1A BCL2 FGF9
10 hearing/vestibular/ear MP:0005377 10.25 E2F1 FGF2 EXT1 BCL2 CDKN1A BMP2
11 hematopoietic system MP:0005397 10.24 VIM E2F1 CDKN1A BMP2 BCL2 FGFR1
12 immune system MP:0005387 10.21 VIM E2F1 CDKN1A BMP2 BCL2 FGFR1
13 endocrine/exocrine gland MP:0005379 10.17 CDKN1A E2F1 BMPR1B BCL2 FGFR1 FGF9
14 integument MP:0010771 10.15 EXT1 E2F1 CDKN1A BCL2 FGF9 FGFR1
15 nervous system MP:0003631 10.15 VIM EXT1 E2F1 CDKN1A BMP2 BCL2
16 limbs/digits/tail MP:0005371 10.13 EXT1 BMP2 CDKN1A BMPR1B FGF9 FGFR1
17 muscle MP:0005369 10.03 VIM E2F1 CDKN1A BCL2 FGFR1 FGF9
18 reproductive system MP:0005389 10.03 VIM E2F1 FGF2 CDKN1A BCL2 BMPR1B
19 normal MP:0002873 9.92 EXT1 E2F1 BMP2 BMPR1B FGFR1 FGF9
20 neoplasm MP:0002006 9.88 EXT1 E2F1 CDKN1A BCL2 FGF2 FGFR3
21 skeleton MP:0005390 9.73 E2F1 EXT2 EXT1 BMP2 CDKN1A BMPR1B
22 respiratory system MP:0005388 9.7 VIM E2F1 CDKN1A FGF9 TGFB2 PTHLH
23 vision/eye MP:0005391 9.4 E2F1 FGF2 EXT1 BCL2 BMPR1B CDKN1A

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3 Analgesics Phase 4,Not Applicable
4 Central Nervous System Depressants Phase 4
5 Narcotics Phase 4
6 Cyclooxygenase 2 Inhibitors Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Analgesics, Opioid Phase 4
10 Peripheral Nervous System Agents Phase 4,Not Applicable
11 Anti-Inflammatory Agents Phase 4,Not Applicable
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4
13 Antirheumatic Agents Phase 4
14
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
15
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
16 Prednisolone acetate Not Applicable
17 glucocorticoids Not Applicable
18 Methylprednisolone acetate Not Applicable
19 Methylprednisolone Hemisuccinate Not Applicable
20 Gastrointestinal Agents Not Applicable
21 Neuroprotective Agents Not Applicable
22 Hormone Antagonists Not Applicable
23 Hormones Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
25 Prednisolone hemisuccinate Not Applicable
26 Prednisolone phosphate Not Applicable
27 Antiemetics Not Applicable
28 Protective Agents Not Applicable
29 Autonomic Agents Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4 etoricoxib;tramadol
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
5 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
6 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
7 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
8 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
9 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393 Not Applicable
10 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
11 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
12 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
13 Predicting Response to Intra-Articular Corticosteroid Injection in Patients With Osteoarthritis of the Glenohumeral Joint Recruiting NCT03232749 Not Applicable corticosteroid injections
14 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
15 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100 Not Applicable
16 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
17 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Genetic tests related to Osteochondroma:

# Genetic test Affiliating Genes
1 Osteochondroma 29

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

41
Bone, Spinal Cord, Tongue, Appendix, Testes, Liver, Lymph Node

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 784)
# Title Authors Year
1
Osteochondroma of the Zygomatic Arch: A Case Report and Review of the Literature. ( 29684307 )
2018
2
Subungual exostosis and subungual osteochondromas: a description of 25 cases. ( 29704255 )
2018
3
A multidisciplinary approach for the treatment of young patients with suprasellar osteochondroma. ( 29067502 )
2018
4
Solitary anterior osteochondroma of cervical spine: An unusual cause of dysphagia and review of literature. ( 29928094 )
2018
5
Solitary facet joint osteochondroma of the upper thoracic spine: An unusual cause of cord compression in the pediatric age group. ( 29547195 )
2018
6
Solitary Osteochondroma of the Spine-A Case Series: Review of Solitary Osteochondroma With Myelopathic Symptoms. ( 29977716 )
2018
7
Osteochondroma of the Scapula with Accessory Nerve (XI) Compression. ( 29785314 )
2018
8
Rare Osteochondroma Associated with Natural Mortality of a Wild White-Tailed Deer ( Odocoileus virginianus). ( 29369726 )
2018
9
Occlusal adjustment after local resection of type 1 condylar osteochondroma. ( 29517694 )
2018
10
Current paediatric orthopaedic practice in hereditary multiple osteochondromas of the forearm: a systematic review. ( 29565244 )
2018
11
Osteochondroma of ventral scapula associated with chest pain due to rib cage compression: A case report. ( 29703017 )
2018
12
Ulnar Lengthening/Reconstruction of Interosseous Membrane in Treatment of Osteochondroma. ( 29576923 )
2018
13
Digital cutting guide and endoscopically-assisted vertical ramus osteotomy to treat condylar osteochondroma: a long-term study. ( 29895393 )
2018
14
Huge Bursitis and Bursal Synovial Osteochondromatosis associated with Scapular Osteochondroma Mimicking a Giant Calcific Mass of the Chest Wall: A Case Report. ( 29905601 )
2018
15
Solitary Osteochondroma of the Ventral Scapula Associated with Large Bursa Formation and Pseudowinging of the Scapula: A Case Report and Literature Review. ( 29666735 )
2018
16
Novel exostosin-2 mutation identified in a Chinese family with hereditary multiple osteochondroma. ( 29541207 )
2018
17
Scapular osteochondroma with winging: A case report. ( 29614444 )
2018
18
Multiple Hereditary Exostoses with Tetraparesis due to Cervical Spine Osteochondroma. ( 29783013 )
2018
19
Solitary osteochondroma of the capitate, in a child. ( 29628715 )
2018
20
Peripheral Osteochondroma of Buccal Mucosa. ( 29690980 )
2018
21
Insufficiency fracture at an osteochondroma bridging the proximal fibula and the tibia: Case report. ( 29881159 )
2018
22
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion. ( 29596896 )
2018
23
Incidental finding of pelvic osteochondroma. ( 29548897 )
2018
24
Huge Bursitis Associated With Scapular Osteochondroma Presenting as a Giant Mass of the Chest Wall: A Case Presentation. ( 29524608 )
2018
25
Osteosarcoma in the coracoid process that mimicked an osteochondroma: A case report. ( 29145279 )
2017
26
Surgical Hip Dislocation for Management of Acetabular Osteochondroma in an Adult. ( 28811949 )
2017
27
Thoracic spinal osteochondroma: A rare presentation of spinal cord compression. ( 28577449 )
2017
28
Identification of a new mutation in an Iranian family with hereditary multiple osteochondromas. ( 28053536 )
2017
29
Pediatric Trigger Finger due to Osteochondroma: A Report of Two Cases. ( 28082852 )
2017
30
Transpedicular excision of a thoracic intraspinal osteochondroma in a patient with Hereditary Multiple Exostoses and Brown-Sequard syndrome: a case report. ( 29258931 )
2017
31
Osteochondroma of the Hyoid: First Pediatric Case and Literature Review. ( 28728426 )
2017
32
Type IV popliteal arterial entrapment associated with an osteochondroma. ( 29349380 )
2017
33
Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses. ( 29120519 )
2017
34
Excision of Solitary Osteochondroma on the Ventral Aspect of Left Scapula Presenting as Pseudowinging in a 4-year-old Boy: A Rare Case Report. ( 28630837 )
2017
35
Isolated acetabular osteochondroma of the hip. ( 28869065 )
2017
36
Identification of a novel mutation in the EXT1 gene from a patient with multiple osteochondromas by exome sequencing. ( 28035357 )
2017
37
Oldest epiphyseal osteochondroma in a subadult from Ancient Egypt. ( 28878530 )
2017
38
An Unusual Presentation of Osteochondroma in a Sexagenarian. ( 29375954 )
2017
39
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. ( 27777159 )
2017
40
Dentofacial Deformity Caused by Bulky Osteochondroma: Report of an Unusual Case and the Importance of Cone Beam Computed Tomography. ( 28553413 )
2017
41
Exophytic Osteochondroma of the Brow. ( 28614150 )
2017
42
Dysplasia epiphysealis hemimelica: a histological comparative study with osteochondromas. ( 28828057 )
2017
43
Teaching NeuroImages: Osteochondroma arising from the clavicle causing ipsilateral Horner syndrome. ( 28696938 )
2017
44
Identification of mutations in EXT1 and EXT2 genes in six Chinese families with multiple osteochondromas. ( 28849184 )
2017
45
Buttock Pain and Sciatica Caused by a Femoral Osteochondroma. ( 28566052 )
2017
46
Secondary Chondrosarcoma from an Osteochondroma of the Proximal Tibia Involving the Fibula. ( 28567230 )
2017
47
Parosteal Osteosarcoma of the Distal Radius Mimicking an Osteochondroma-A Diagnostic Misadventure. ( 28917546 )
2017
48
Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice. ( 28445472 )
2017
49
Osteochondroma and Spinal Cord Compression in a Patient With Hereditary Multiple Exostoses: A Case Report. ( 28228700 )
2017
50
Pes Anserinus Syndrome Caused by Osteochondroma in Paediatrics: A Case Series Study. ( 28603571 )
2017

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
2
Show member pathways
13.65 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
3
Show member pathways
13.46 BCL2 BMP2 FGF2 FGF9 FGFR1 FGFR3
4
Show member pathways
13.31 BCL2 CDKN1A FGF2 FGF9 FGFR1 FGFR3
5
Show member pathways
13.31 BCL2 BMP2 BMPR1B CDKN1A FGF2 FGFR1
6
Show member pathways
13.23 BMP2 FGF2 FGFR1 FGFR3 TGFB2 VIM
7
Show member pathways
13.23 BCL2 BMP2 BMPR1B FGF2 FGFR1 FGFR3
8
Show member pathways
12.83 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
9
Show member pathways
12.82 BCL2 CDKN1A E2F1 FGFR1 TGFB2
10 12.72 FGF2 FGF9 FGFR1 FGFR3 TGFB2
11
Show member pathways
12.68 CDKN1A FGF2 FGF9 FGFR1 FGFR3
12
Show member pathways
12.64 BMP2 FGF2 FGFR1 FGFR3 TGFB2
13
Show member pathways
12.58 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
14
Show member pathways
12.53 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
15
Show member pathways
12.51 FGF2 FGF9 FGFR1 FGFR3
16
Show member pathways
12.49 BCL2 CDKN1A E2F1 FGF2 TGFB2
17
Show member pathways
12.48 EXT1 EXT2 FGFR1 PTHLH
18
Show member pathways
12.4 FGF2 FGF9 FGFR1 FGFR3
19
Show member pathways
12.4 BCL2 BMPR1B FGFR1 FGFR3
20
Show member pathways
12.38 BMP2 BMPR1B E2F1 FGF2 TGFB2
21
Show member pathways
12.37 FGF2 FGF9 FGFR1 FGFR3
22 12.36 BCL2 CDKN1A E2F1 FGFR3 TGFB2 VIM
23
Show member pathways
12.35 FGF2 FGF9 FGFR1 FGFR3
24 12.33 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
25 12.25 CDKN1A FGF2 FGFR1 TGFB2
26
Show member pathways
12.22 FGF2 FGF9 FGFR1 FGFR3
27
Show member pathways
12.09 FGF2 FGF9 FGFR1 FGFR3
28 12.03 BCL2 CDKN1A E2F1 FGFR1 FGFR3
29
Show member pathways
12.02 E2F1 FGFR1 FGFR3
30 12.01 BMPR1B FGF2 FGFR1 FGFR3
31 11.91 BCL2 CDKN1A FGF2 VIM
32 11.91 BCL2 BMP2 CDKN1A E2F1 TGFB2
33 11.88 FGF2 FGFR1 FGFR3
34 11.85 BCL2 CDKN1A FGFR1 PTHLH
35 11.84 BCL2 BMP2 CDKN1A E2F1
36 11.83 BCL2 CDKN1A E2F1
37
Show member pathways
11.82 FGF2 FGF9 FGFR1
38
Show member pathways
11.81 BCL2 BMP2 CDKN1A FGF2 FGFR1 FGFR3
39 11.77 BMP2 BMPR1B TGFB2
40 11.75 FGF2 FGFR1 FGFR3 TGFB2
41 11.7 CDKN1A E2F1 FGFR3
42
Show member pathways
11.58 FGF2 FGF9 FGFR3
43 11.48 FGF2 FGFR1 TGFB2
44 11.44 BCL2 CDKN1A E2F1
45 11.38 FGF2 FGFR1 FGFR3
46 11.37 FGF2 FGFR1 FGFR3 PTHLH TGFB2
47 11.06 BMP2 FGF2 FGFR1 FGFR3 NES S100B

GO Terms for Osteochondroma

Cellular components related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 BMP2 FGF2 FGF9 FGFR1 FGFR3 PTHLH

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.97 FGF2 FGF9 FGFR1 FGFR3
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 BMP2 FGF2 FGFR1 FGFR3
3 angiogenesis GO:0001525 9.95 FGF2 FGF9 FGFR1 TGFB2
4 negative regulation of gene expression GO:0010629 9.94 BMP2 CDKN1A FGFR1 TGFB2
5 cell-cell signaling GO:0007267 9.91 BMP2 FGF9 FGFR3 PTHLH TGFB2
6 animal organ morphogenesis GO:0009887 9.89 BCL2 BMP2 FGF2
7 negative regulation of cell growth GO:0030308 9.88 BCL2 CDKN1A TGFB2
8 cellular response to hypoxia GO:0071456 9.88 BCL2 E2F1 S100B
9 peptidyl-tyrosine phosphorylation GO:0018108 9.88 FGF2 FGF9 FGFR1 FGFR3
10 male gonad development GO:0008584 9.87 BCL2 FGF9 TGFB2
11 positive regulation of protein kinase B signaling GO:0051897 9.87 FGF2 FGF9 FGFR1 FGFR3
12 BMP signaling pathway GO:0030509 9.85 BMP2 BMPR1B TGFB2
13 response to glucocorticoid GO:0051384 9.8 BCL2 CDKN1A S100B
14 SMAD protein signal transduction GO:0060395 9.79 BMP2 TGFB2 VIM
15 embryonic limb morphogenesis GO:0030326 9.77 FGF9 FGFR1 TGFB2
16 positive regulation of cell proliferation GO:0008284 9.76 BCL2 FGF2 FGF9 FGFR1 FGFR3 PTHLH
17 positive regulation of cell division GO:0051781 9.75 FGF2 FGF9 TGFB2
18 branching involved in ureteric bud morphogenesis GO:0001658 9.73 BCL2 BMP2 FGF2
19 phosphatidylinositol phosphorylation GO:0046854 9.73 FGF2 FGF9 FGFR1 FGFR3
20 positive regulation of MAPK cascade GO:0043410 9.72 BMP2 DUSP19 FGF9 FGFR1 FGFR3
21 embryonic digestive tract development GO:0048566 9.71 FGF9 TGFB2
22 ossification GO:0001503 9.71 BCL2 BMP2 EXT1 EXT2
23 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.7 EXT1 EXT2
24 endocardial cushion morphogenesis GO:0003203 9.7 BMP2 TGFB2
25 positive regulation of cartilage development GO:0061036 9.7 BMP2 BMPR1B
26 positive regulation of cardiac muscle cell proliferation GO:0060045 9.7 FGF2 FGF9 FGFR1
27 positive regulation of ossification GO:0045778 9.69 BMP2 TGFB2
28 generation of neurons GO:0048699 9.68 FGFR1 TGFB2
29 ear development GO:0043583 9.68 BCL2 FGFR1
30 cardiac epithelial to mesenchymal transition GO:0060317 9.68 BMP2 TGFB2
31 pathway-restricted SMAD protein phosphorylation GO:0060389 9.67 BMP2 TGFB2
32 atrioventricular valve morphogenesis GO:0003181 9.67 BMP2 TGFB2
33 bone mineralization GO:0030282 9.67 BMP2 FGFR3 PTHLH
34 fibroblast growth factor receptor signaling pathway GO:0008543 9.67 FGF2 FGF9 FGFR1 FGFR3
35 mesenchymal cell differentiation GO:0048762 9.66 BMP2 FGFR1
36 salivary gland morphogenesis GO:0007435 9.66 FGFR1 TGFB2
37 stem cell proliferation GO:0072089 9.65 FGF2 NES
38 eye development GO:0001654 9.65 BMPR1B FGF9 TGFB2
39 positive regulation of phospholipase C activity GO:0010863 9.64 FGF2 FGFR1
40 positive regulation of phospholipase activity GO:0010518 9.63 FGFR1 FGFR3
41 lung-associated mesenchyme development GO:0060484 9.63 FGF9 FGFR1
42 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.6 EXT1 EXT2
43 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.56 FGF2 FGF9 FGFR1 FGFR3
44 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.55 FGF2 FGFR1
45 cellular polysaccharide biosynthetic process GO:0033692 9.46 EXT1 EXT2
46 chondrocyte differentiation GO:0002062 9.35 BMP2 BMPR1B FGF9 FGFR1 FGFR3
47 skeletal system development GO:0001501 9.17 BMP2 BMPR1B EXT1 FGFR1 FGFR3 PTHLH
48 protein phosphorylation GO:0006468 10.09 BMP2 BMPR1B FGFR1 FGFR3 TGFB2
49 cell differentiation GO:0030154 10.08 BMP2 BMPR1B EXT2 FGF2 FGF9 FGFR1
50 regulation of signaling receptor activity GO:0010469 10.02 BMP2 FGF2 FGF9 PTHLH TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.97 BCL2 EXT1 EXT2 FGFR1 S100B TGFB2
2 protein heterodimerization activity GO:0046982 9.91 BCL2 BMP2 EXT1 EXT2 TGFB2
3 protein tyrosine kinase activity GO:0004713 9.76 FGF2 FGF9 FGFR1 FGFR3
4 growth factor activity GO:0008083 9.73 BMP2 FGF2 FGF9 TGFB2
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.56 FGF2 FGF9 FGFR1 FGFR3
6 BMP receptor binding GO:0070700 9.52 BMP2 TGFB2
7 fibroblast growth factor-activated receptor activity GO:0005007 9.48 FGFR1 FGFR3
8 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.4 EXT1 EXT2
9 receptor-receptor interaction GO:0090722 9.37 FGF2 FGFR1
10 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.32 EXT1 EXT2
11 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF2 FGF9 FGFR1 FGFR3
12 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.16 EXT1 EXT2
13 1-phosphatidylinositol-3-kinase activity GO:0016303 8.92 FGF2 FGF9 FGFR1 FGFR3

Sources for Osteochondroma

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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69 SNOMED-CT via HPO
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