MCID: OST028
MIFTS: 45

Osteochondroma

Categories: Bone diseases, Cancer diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Osteochondroma

MalaCards integrated aliases for Osteochondroma:

Name: Osteochondroma 52 54 17
Cartilaginous Exostosis 71

Classifications:



External Ids:

UMLS 71 C0029423

Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and dysplasia epiphysealis hemimelica. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Tretinoin and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Osteochondromas are the most common benign tumors of the bones. The tumors take the form of... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 324)
# Related Disease Score Top Affiliating Genes
1 hereditary multiple osteochondromas 35.2 EXT2 EXT1
2 dysplasia epiphysealis hemimelica 31.3 EXT2 EXT1
3 exostosis 31.1 EXT2 EXT1 BMP2
4 juxtacortical chondroma 30.7 EXT2 EXT1
5 fgfr-related craniosynostosis syndromes 30.3 FGFR3 FGFR1
6 muenke syndrome 30.3 FGFR3 FGFR1 FGF9
7 enchondromatosis, multiple, ollier type 30.3 PTHLH FGFR3 EXT2 EXT1
8 periosteal chondrosarcoma 30.2 NCOA2 EXT1
9 spindle cell sarcoma 30.1 VIM S100B NCOA2
10 chondroblastoma 30.1 PTHLH FGFR3 FGFR1
11 neuroma 29.9 S100B FGFR1 FGF2
12 mesenchymal chondrosarcoma 29.9 VIM NCOA2 HEY1
13 synovial chondromatosis 29.8 FGFR3 FGFR1 FGF9 FGF2 BMP2
14 osteogenic sarcoma 29.8 PTHLH E2F1 CDKN1A BMP2
15 sarcoma, synovial 29.6 VIM S100B NES BCL2
16 neurilemmoma 29.5 VIM S100B NES
17 chromosome 2q35 duplication syndrome 29.2 FGFR3 FGFR1 BMPR1B BMP2
18 chondrosarcoma 28.9 VIM S100B PTHLH NCOA2 FGFR3 FGF2
19 craniosynostosis 28.8 FGFR3 FGFR1 FGF9 FGF2 BMP2
20 sarcoma 28.6 VIM S100B FGFR3 FGFR1 FGF2 E2F1
21 bone disease 28.4 PTHLH FGFR3 FGFR1 FGF9 EXT2 EXT1
22 medulloblastoma 27.7 VIM S100B NES FGFR1 FGF2 CDKN1A
23 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.6
24 exostoses, multiple, type i 12.3
25 exostoses, multiple, type ii 11.9
26 metachondromatosis 11.9
27 hereditary multiple exostoses 11.8
28 trichorhinophalangeal syndrome, type ii 11.8
29 exostoses, multiple, type iii 11.7
30 potocki-shaffer syndrome 11.3
31 chondroma 10.5
32 frozen shoulder 10.4
33 bursitis 10.4
34 actinic cheilitis 10.4 CDKN1A BCL2
35 camptodactyly-tall stature-scoliosis-hearing loss syndrome 10.4 FGFR3 EXT1
36 plagiocephaly 10.4 FGFR3 FGFR1
37 multiple enchondromatosis, maffucci type 10.4 PTHLH EXT2 EXT1
38 syndromic craniosynostosis 10.4 FGFR3 FGFR1
39 radiculopathy 10.3
40 localized chondrosarcoma 10.3 FGFR1 EXT2 EXT1
41 osteoglophonic dysplasia 10.3 FGFR3 FGFR1
42 aneurysm 10.3
43 back pain 10.3
44 synostoses, tarsal, carpal, and digital 10.3 FGF9 BMPR1B
45 parietal foramina 10.3 FGFR3 EXT2 BMPR1B
46 suppressor of tumorigenicity 3 10.3 CDKN1A BCL2
47 head injury 10.3 S100B BCL2
48 cheilitis 10.3 FGFR3 CDKN1A BCL2
49 extraskeletal mesenchymal chondrosarcoma 10.3 NCOA2 HEY1
50 thrombosis 10.3

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.6 FGFR3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.6 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.6 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.6 BCL2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.6 TGFB2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.6 TGFB2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.6 NCOA2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.6 BCL2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.6 BCL2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.6 NCOA2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.6 NCOA2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.6 BCL2 FGFR3 NCOA2 TGFB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.6 BCL2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.6 TGFB2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.6 TGFB2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.6 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.47 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
2 behavior/neurological MP:0005386 10.39 BCL2 CDKN1A E2F1 EXT1 FGF2 FGF9
3 embryo MP:0005380 10.39 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
4 craniofacial MP:0005382 10.37 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
5 growth/size/body region MP:0005378 10.37 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
6 cardiovascular system MP:0005385 10.35 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
7 mortality/aging MP:0010768 10.35 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
8 homeostasis/metabolism MP:0005376 10.3 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
9 digestive/alimentary MP:0005381 10.28 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF9
10 hematopoietic system MP:0005397 10.28 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
11 hearing/vestibular/ear MP:0005377 10.25 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF2
12 endocrine/exocrine gland MP:0005379 10.22 BCL2 BMPR1B CDKN1A E2F1 FGF9 FGFR1
13 nervous system MP:0003631 10.22 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
14 integument MP:0010771 10.21 BCL2 CDKN1A E2F1 EXT1 FGF9 FGFR1
15 limbs/digits/tail MP:0005371 10.15 BMP2 BMPR1B CDKN1A EXT1 FGF9 FGFR1
16 muscle MP:0005369 10.11 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
17 normal MP:0002873 10.07 BMP2 BMPR1B E2F1 EXT1 FGF9 FGFR1
18 reproductive system MP:0005389 10.07 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
19 neoplasm MP:0002006 9.98 BCL2 CDKN1A E2F1 EXT1 FGF2 FGFR3
20 renal/urinary system MP:0005367 9.87 BCL2 CDKN1A FGF9 FGFR1 FGFR3 PTHLH
21 skeleton MP:0005390 9.73 BMP2 BMPR1B CDKN1A E2F1 EXT1 EXT2
22 respiratory system MP:0005388 9.7 CDKN1A E2F1 FGF9 FGFR3 PTHLH TGFB2
23 vision/eye MP:0005391 9.4 BCL2 BMPR1B CDKN1A E2F1 EXT1 FGF2

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
2 Dermatologic Agents Phase 2
3 Keratolytic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Palovarotene in Subjects With Multiple Osteochondromas Active, not recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
2 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
3 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
4 FOP Connection: A Global Registry for the Fibrodysplasia Ossificans Progressiva Community Recruiting NCT02745158
5 Registry of Multiple Osteochondromas That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Quality of Life Data. Data Are Linked to Patients Biological Sample Enrolling by invitation NCT04133285
6 Genotype-Phenotype Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
7 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

40
Bone, Spinal Cord, Pituitary, Tongue, Thyroid, Breast, Bone Marrow

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 2096)
# Title Authors PMID Year
1
Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones. 54 61
17490719 2007
2
Soft tissue osteochondroma: case report and immunohistochemistry for parathyroid hormone-related protein. 54 61
16844564 2006
3
Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients. 54 61
16476576 2006
4
Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. 54 61
16026543 2005
5
Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma. 54 61
15796962 2005
6
The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting. 54 61
15744499 2005
7
Immunohistochemical study of chondrolipoma: possible importance of transforming growth factor (TGF)-betas, latent TGF-beta binding protein-1 (LTBP-1), and bone morphogenetic protein (BMP) for chondrogenesis in lipoma. 54 61
12692354 2003
8
The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. 54 61
12645631 2003
9
Cytogenetic and molecular cytogenetic evidence of recurrent 8q24.1 loss in osteochondroma. 54 61
12393280 2002
10
Hereditary multiple exostoses: one center's experience and review of etiology. 54 61
12151882 2002
11
[From gene to disease; hereditary multiple exostoses]. 54 61
11845565 2002
12
Involvement of BMP-2 signaling in a cartilage cap in osteochondroma. 54 61
11781009 2001
13
Ext-mutation analysis in Italian sporadic and hereditary osteochondromas. 54 61
11668521 2001
14
Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. 54 61
11140704 2000
15
Expression of cell cycle-associated proteins CDK4, p27, and E2F-1 in chondrosarcoma of the jaws. 54 61
11314534 2000
16
EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. 54 61
10441575 1999
17
The neoplastic pathogenesis of solitary and multiple osteochondromas. 54 61
10398153 1999
18
Clonal karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas. 54 61
9576285 1998
19
Selective increase in expression of isoform PP1 gamma 1 of type-1 protein phosphatase in chondrosarcoma cells. 54 61
7712113 1994
20
Tumors of the scapula: A retrospective analysis identifying predictors of malignancy. 61
31689646 2020
21
Effect of Distal Ulna Osteochondroma Excision and Distal Ulnar Tether Release on Forearm Deformity in Preadolescent Patients With Multiple Hereditary Exostosis. 61
31386642 2020
22
Radial osteotomy for the correction of forearm deformities in hereditary multiple osteochondroma. 61
31734296 2020
23
Osteochondroma of the Pubic Symphysis Involved With Aberrantly Placed Minisling: A Case Report. 61
31306181 2020
24
Ventral scapular osteochondroma excision through 'triangle of auscultation': A case series. 61
31916491 2020
25
Intracanalicular Osteochondroma in the Lumbar Spine. 61
31938676 2020
26
Superomedial Portal (Ejnisman's Portal) and Modified "Chicken-Wing" Patient Position for Scapulothoracic Arthroscopy. 61
32021774 2020
27
Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K/Akt signaling pathway. 61
31746363 2020
28
Behind The Façade: Robotic-Assisted Resection of a Diaphragmatic Osteochondroma. 61
31805263 2019
29
Solitary Sacral Osteochondroma Causing Postural Difficulty in a Young Female: A Case Report and a Review of the Literature. 61
32025397 2019
30
Condylectomy as the treatment for active unilateral condylar hyperplasia of the mandible and severe facial asymmetry: retrospective review over 18 years. 61
31262682 2019
31
Spinal Screening MRI Trends in Patients with Multiple Hereditary Exostoses: National Survey. 61
32010535 2019
32
Talus localized osteochondromas: Treatment management and mid-term outcomes - Case series. 61
31650930 2019
33
Sarcomatous Transformation of Recurrent Scapular Osteochondroma in a Patient with the Hereditary Multiple Osteochondromas: A Case Report and Literature Review. 61
31938600 2019
34
Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS-2/8 Chondrosarcoma Cells. 61
31808569 2019
35
Histopathological features of condylar hyperplasia and condylar Osteochondroma: a comparison study. 61
31842965 2019
36
Femoral osteochondroma responsible for ischiofemoral impingement, bursitis, and secondary lipoma arborescens mimicking malignant transformation. 61
31903223 2019
37
Can preoperative imaging predict the outcomes after arthroscopic release for elbow arthritis? 61
31563416 2019
38
An Unusual Location of Osteochondroma: Dorsal Scapula. 61
32025393 2019
39
Isolated primary bone tumours of the lesser trochanter: Demographics, diagnosis and management. 61
31736612 2019
40
A three-dimensional study of hemimandibular hyperplasia, hemimandibular elongation, solitary condylar hyperplasia, simple mandibular asymmetry and condylar osteoma or osteochondroma. 61
31473057 2019
41
Arthroscopic Femoral Osteochondroplasty With Capsular Plication for Osteochondroma of the Femoral Neck. 61
31890507 2019
42
Total hip arthroplasty in hereditary multiple exostoses with secondary osteoarthritis: A case report. 61
31770268 2019
43
Pediatric navicular dorsal osteochondroma: a rare case of navicular-cuneiform impingement. 61
30855546 2019
44
Benign bone tumours of tibial tuberosity clinically mimicking Osgood-Schlatter disease: a case series. 61
31511951 2019
45
Is the Width of a Surgical Margin Associated with the Outcome of Disease in Patients with Peripheral Chondrosarcoma of the Pelvis? A Multicenter Study. 61
31453886 2019
46
Osteochondroma Arising from the Transverse Process of the Lower Cervical Spine in an Elderly Patient. 61
31356982 2019
47
Secondary chondrosarcoma arising from osteochondroma: outcomes and prognostic factors. 61
31564158 2019
48
Malignant Transformation of Recurrent Synovial Chondromatosis: A Case Report and Review. 61
31754574 2019
49
Histological, epidemiological and anatomical analysis of 193 bone tumours of the scapula. 61
31497502 2019
50
Insights into the molecular regulatory network of pathomechanisms in osteochondroma. 61
31211456 2019

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.16 S100B PTHLH NCOA2 HEY1 FGFR3 FGFR1
2
Show member pathways
13.74 VIM TGFB2 FGFR3 FGFR1 FGF2 E2F1
3
Show member pathways
13.55 TGFB2 NCOA2 FGFR3 FGFR1 FGF9 FGF2
4
Show member pathways
13.51 TGFB2 FGFR3 FGFR1 FGF9 FGF2 CDKN1A
5
Show member pathways
13.35 TGFB2 FGFR3 FGFR1 FGF2 CDKN1A BMPR1B
6
Show member pathways
13.33 VIM FGFR3 FGFR1 FGF9 FGF2 CDKN1A
7
Show member pathways
13.26 TGFB2 FGFR3 FGFR1 FGF2 BMPR1B BMP2
8
Show member pathways
12.84 TGFB2 FGFR1 E2F1 CDKN1A BCL2
9
Show member pathways
12.76 HEY1 FGFR3 FGFR1 FGF9 FGF2 E2F1
10 12.73 TGFB2 FGFR3 FGFR1 FGF9 FGF2
11
Show member pathways
12.7 FGFR3 FGFR1 FGF9 FGF2 CDKN1A
12
Show member pathways
12.66 TGFB2 FGFR3 FGFR1 FGF2 BMP2
13
Show member pathways
12.58 TGFB2 FGFR3 FGF2 CDKN1A BCL2
14
Show member pathways
12.53 FGFR1 FGF9 FGF2 E2F1 CDKN1A BCL2
15
Show member pathways
12.49 PTHLH FGFR1 EXT2 EXT1
16
Show member pathways
12.42 TGFB2 HEY1 FGFR1 FGF9 FGF2 E2F1
17
Show member pathways
12.41 FGFR3 FGFR1 BMPR1B BCL2
18
Show member pathways
12.39 TGFB2 FGF2 E2F1 BMPR1B BMP2
19
Show member pathways
12.38 FGFR3 FGFR1 FGF9 FGF2
20 12.38 TGFB2 HEY1 FGFR3 FGFR1 FGF9 FGF2
21
Show member pathways
12.37 FGFR3 FGFR1 FGF9 FGF2
22
Show member pathways
12.37 TGFB2 FGFR3 FGFR1 FGF2 BMP2
23
Show member pathways
12.37 FGFR3 FGFR1 FGF9 FGF2
24 12.34 VIM TGFB2 FGFR3 E2F1 CDKN1A BCL2
25 12.27 TGFB2 FGFR1 FGF2 CDKN1A
26
Show member pathways
12.24 FGFR3 FGFR1 FGF9 FGF2
27
Show member pathways
12.21 TGFB2 FGFR3 FGFR1 FGF2 BMP2
28
Show member pathways
12.14 FGFR3 FGFR1 E2F1 CDKN1A BCL2
29
Show member pathways
12.12 FGFR3 FGFR1 FGF9 FGF2
30 12.04 FGFR3 FGFR1 FGF2 BMPR1B
31 12 NCOA2 E2F1 CDKN1A BMP2
32 11.89 FGFR3 FGFR1 FGF2
33 11.89 VIM FGF2 CDKN1A BCL2
34 11.85 TGFB2 BMPR1B BMP2
35 11.85 E2F1 CDKN1A BMP2 BCL2
36 11.84 E2F1 CDKN1A BCL2
37 11.84 PTHLH FGFR1 CDKN1A BCL2
38
Show member pathways
11.82 FGFR1 FGF9 FGF2
39 11.75 TGFB2 FGFR3 FGFR1 FGF2
40 11.71 FGFR3 E2F1 CDKN1A
41 11.67 TGFB2 FGFR3 FGFR1 FGF2 BMP2
42
Show member pathways
11.58 FGFR3 FGF9 FGF2
43 11.56 TGFB2 E2F1 CDKN1A BMP2 BCL2
44 11.5 TGFB2 FGFR1 FGF2
45 11.47 E2F1 CDKN1A BCL2
46 11.47 TGFB2 PTHLH FGFR3 FGFR1 FGF2
47 11.42 FGFR3 FGFR1 FGF2
48 11.06 VIM S100B NES FGFR3 FGFR1 FGF2
49 10.85 VIM TGFB2 FGFR3 FGFR1 FGF2 BMP2

GO Terms for Osteochondroma

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.16 HEY1 FGF9 FGF2 EXT2 BMPR1B BMP2
2 negative regulation of transcription by RNA polymerase II GO:0000122 10.12 NCOA2 HEY1 FGFR1 FGF9 E2F1 BMP2
3 positive regulation of gene expression GO:0010628 10.02 VIM HEY1 FGF9 E2F1 BMP2
4 negative regulation of cell proliferation GO:0008285 10 TGFB2 PTHLH CDKN1A BMP2 BCL2
5 cytokine-mediated signaling pathway GO:0019221 9.99 VIM FGF2 CDKN1A BCL2
6 negative regulation of gene expression GO:0010629 9.98 TGFB2 FGFR1 CDKN1A BMP2
7 MAPK cascade GO:0000165 9.96 FGFR3 FGFR1 FGF9 FGF2
8 regulation of gene expression GO:0010468 9.96 PTHLH NCOA2 FGFR1 BCL2
9 cell-cell signaling GO:0007267 9.94 PTHLH FGFR3 FGF9 BMP2
10 positive regulation of protein kinase B signaling GO:0051897 9.88 FGFR3 FGFR1 FGF9 FGF2
11 male gonad development GO:0008584 9.87 TGFB2 FGF9 BCL2
12 angiogenesis GO:0001525 9.85 TGFB2 HEY1 FGFR1 FGF9 FGF2
13 BMP signaling pathway GO:0030509 9.84 TGFB2 BMPR1B BMP2
14 response to glucocorticoid GO:0051384 9.79 S100B CDKN1A BCL2
15 SMAD protein signal transduction GO:0060395 9.77 VIM TGFB2 BMP2
16 embryonic limb morphogenesis GO:0030326 9.76 TGFB2 FGFR1 FGF9
17 positive regulation of cell proliferation GO:0008284 9.76 TGFB2 S100B PTHLH FGFR3 FGFR1 FGF9
18 positive regulation of cell differentiation GO:0045597 9.74 FGFR1 BMPR1B BMP2
19 positive regulation of cell division GO:0051781 9.73 TGFB2 FGF9 FGF2
20 ossification GO:0001503 9.73 EXT2 EXT1 BMP2 BCL2
21 bone mineralization GO:0030282 9.72 PTHLH FGFR3 BMP2
22 branching involved in ureteric bud morphogenesis GO:0001658 9.71 FGF2 BMP2 BCL2
23 fibroblast growth factor receptor signaling pathway GO:0008543 9.71 FGFR3 FGFR1 FGF9 FGF2
24 positive regulation of cartilage development GO:0061036 9.7 BMPR1B BMP2
25 positive regulation of ossification GO:0045778 9.69 TGFB2 BMP2
26 ear development GO:0043583 9.69 FGFR1 BCL2
27 pulmonary valve morphogenesis GO:0003184 9.69 TGFB2 HEY1
28 positive regulation of cardiac muscle cell proliferation GO:0060045 9.69 FGFR1 FGF9 FGF2
29 pathway-restricted SMAD protein phosphorylation GO:0060389 9.68 TGFB2 BMP2
30 generation of neurons GO:0048699 9.67 TGFB2 FGFR1
31 positive regulation of phospholipase C activity GO:0010863 9.67 FGFR1 FGF2
32 atrioventricular valve morphogenesis GO:0003181 9.67 TGFB2 BMP2
33 eye development GO:0001654 9.67 TGFB2 FGF9 BMPR1B
34 mesenchymal cell differentiation GO:0048762 9.65 FGFR1 BMP2
35 salivary gland morphogenesis GO:0007435 9.65 TGFB2 FGFR1
36 positive regulation of MAPK cascade GO:0043410 9.65 FGFR3 FGFR1 FGF9 DUSP19 BMP2
37 stem cell proliferation GO:0072089 9.63 NES FGF2
38 positive regulation of phospholipase activity GO:0010518 9.63 FGFR3 FGFR1
39 lung-associated mesenchyme development GO:0060484 9.61 FGFR1 FGF9
40 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.61 EXT2 EXT1
41 endocardial cushion morphogenesis GO:0003203 9.54 TGFB2 HEY1 BMP2
42 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.52 FGFR1 FGF2
43 cardiac epithelial to mesenchymal transition GO:0060317 9.5 TGFB2 HEY1 BMP2
44 cellular polysaccharide biosynthetic process GO:0033692 9.48 EXT2 EXT1
45 chondrocyte differentiation GO:0002062 9.35 FGFR3 FGFR1 FGF9 BMPR1B BMP2
46 skeletal system development GO:0001501 9.17 TGFB2 PTHLH FGFR3 FGFR1 EXT1 BMPR1B

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.33 VIM TGFB2 S100B PTHLH NES NCOA2
2 protein homodimerization activity GO:0042803 9.91 TGFB2 S100B FGFR1 EXT2 EXT1 BCL2
3 protein heterodimerization activity GO:0046982 9.85 TGFB2 EXT2 EXT1 BMP2 BCL2
4 growth factor activity GO:0008083 9.56 TGFB2 FGF9 FGF2 BMP2
5 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.37 EXT2 EXT1
6 fibroblast growth factor-activated receptor activity GO:0005007 9.32 FGFR3 FGFR1
7 receptor-receptor interaction GO:0090722 9.16 FGFR1 FGF2
8 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.96 EXT2 EXT1
9 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.62 EXT2 EXT1

Sources for Osteochondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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