MCID: OST016
MIFTS: 53

Osteochondrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Osteochondrosis

MalaCards integrated aliases for Osteochondrosis:

Name: Osteochondrosis 12 52 58 15 37 17 71
Osteochondritis 12 74 71
Osteochondritis Juvenilis 12 71
Apophysitis 12 71
Epiphysitis 12 71
Juvenile Osteochondrosis of Tibial Tubercle 71
Epiphyseal Necrosis 12

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:8125
ICD9CM 34 732.6
MeSH 43 D055034
NCIt 49 C34879
SNOMED-CT 67 19579005 65477003
ICD10 32 M92 M93.9
ICD10 via Orphanet 33 M93.9
UMLS via Orphanet 72 C0029429
Orphanet 58 ORPHA399319
UMLS 71 C0014574 C0029376 C0029420 more

Summaries for Osteochondrosis

Disease Ontology : 12 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis, is related to multiple epiphyseal dysplasia and scheuermann disease. An important gene associated with Osteochondrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Cysteine and HIV Protease Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and bone marrow, and related phenotypes are behavior/neurological and cellular

Wikipedia : 74 Osteochondritis is a painful type of osteochondrosis where the cartilage or bone in a joint is... more...

Related Diseases for Osteochondrosis

Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 715)
# Related Disease Score Top Affiliating Genes
1 multiple epiphyseal dysplasia 34.4 COL9A3 COL2A1 ACAN
2 scheuermann disease 34.0 PES1 COL9A3 COL2A1
3 kohler's disease 33.8 PES1 HECTD4 COL2A1
4 blount's disease 33.6 PES1 GALNS
5 osgood-schlatter's disease 33.4 PES1 HECTD4
6 achilles bursitis 32.9 PES1 HECTD4
7 spondyloepimetaphyseal dysplasia, matrilin-3 related 32.6 GALNS COL2A1 ACAN
8 spondyloepimetaphyseal dysplasia, strudwick type 32.6 COL2A1 COL10A1
9 spondyloepiphyseal dysplasia congenita 32.6 GALNS COL2A1 COL10A1
10 otospondylomegaepiphyseal dysplasia 32.6 COL9A3 COL2A1 COL10A1
11 pseudoachondroplasia 32.3 COL9A3 COL2A1 ACAN
12 spondyloepiphyseal dysplasia with congenital joint dislocations 32.0 GALNS COL9A3 COL2A1 ACAN
13 odontochondrodysplasia 31.6 GALNS COL9A3 COL2A1 COL10A1 ACAN
14 osteochondritis dissecans 31.5 COL9A3 CD36 ACAN
15 coxa vara 30.9 COL2A1 COL10A1
16 arthropathy 30.9 IGF1 COL2A1 ACAN
17 achondroplasia 30.8 IGF1 COL2A1 ACAN
18 diastrophic dysplasia 30.8 TGFB1 COL9A3 COL2A1
19 osteoarthritis 30.7 TGFB1 COL2A1 COL10A1 ACAN
20 exostosis 30.5 PES1 HECTD4 ACAN
21 epicondylitis 30.5 PES1 HECTD4
22 otosclerosis 30.5 VDR TGFB1 CD36
23 chondromalacia 30.4 PES1 ACAN
24 parathyroid adenoma 30.4 VDR TGFB1 IGF1
25 peroneal nerve paralysis 30.4 PES1 HECTD4 COL2A1
26 degenerative disc disease 30.4 VDR COL9A3 ACAN
27 bone resorption disease 30.3 VDR IGF1 HECTD4
28 spinal stenosis 30.3 COL9A3 COL2A1 ACAN
29 brachyolmia 30.2 GALNS COL2A1 ACAN
30 stickler syndrome 30.2 COL9A3 COL2A1 ACAN
31 brittle bone disorder 30.0 COL2A1 COL10A1 CD36 ACAN
32 cartilage disease 30.0 COL2A1 COL10A1 ACAN
33 hyperostosis 30.0 TGFB1 IGF1 COL10A1
34 pyle disease 30.0 GALNS COL2A1 COL10A1
35 bone inflammation disease 30.0 HECTD4 COL2A1 ACAN
36 osteoporosis 29.9 VDR TGFB1 NR3C1 IGF2 IGF1 COL2A1
37 kniest dysplasia 29.9 GALNS COL9A3 COL2A1
38 achondrogenesis 29.9 COL9A3 COL2A1 COL10A1 ACAN
39 scoliosis 29.8 VDR TGFB1 IGF1 COL2A1 COL10A1 ACAN
40 bone disease 29.7 VDR IGF1 COL2A1 COL10A1 CD36 ACAN
41 reflex sympathetic dystrophy 29.7 HECTD4 CD36
42 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.9
43 familial osteochondritis dissecans 12.8
44 epiphyseal dysplasia, multiple, 4 12.7
45 epiphyseal dysplasia, multiple, 5 12.7
46 epiphyseal dysplasia, multiple, 1 12.7
47 epiphyseal dysplasia, multiple, 3 12.7
48 epiphyseal dysplasia, multiple, 2 12.7
49 epiphyseal dysplasia, multiple, with myopia and conductive deafness 12.6
50 epiphyseal dysplasia, multiple, 6 12.6

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

MGI Mouse Phenotypes related to Osteochondrosis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 CD36 COL10A1 COL24A1 COL2A1 GNPTAB IGF2
2 cellular MP:0005384 10.22 CD36 COL10A1 COL2A1 GALNS GNPTAB IGF1
3 growth/size/body region MP:0005378 10.18 CD36 COL10A1 COL24A1 COL2A1 GNPTAB IGF1
4 mortality/aging MP:0010768 10.13 CD36 COL10A1 COL2A1 GNPTAB IGF1 IGF2
5 craniofacial MP:0005382 10.06 COL10A1 COL2A1 GNPTAB IGF2 MMP16 PES1
6 endocrine/exocrine gland MP:0005379 10.06 CD36 COL10A1 GNPTAB IGF1 IGF2 NCDN
7 digestive/alimentary MP:0005381 10.03 CD36 COL2A1 GNPTAB IGF2 MMP16 NR3C1
8 nervous system MP:0003631 9.9 CD36 COL10A1 COL2A1 GNPTAB IGF1 IGF2
9 muscle MP:0005369 9.86 CD36 GNPTAB IGF1 IGF2 NR3C1 TGFB1
10 renal/urinary system MP:0005367 9.61 CD36 COL2A1 GALNS GNPTAB IGF1 IGF2
11 skeleton MP:0005390 9.4 CD36 COL10A1 COL2A1 GALNS GNPTAB IGF1

Drugs & Therapeutics for Osteochondrosis

Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cysteine Approved, Nutraceutical Phase 3 52-90-4 5862
2 HIV Protease Inhibitors Phase 3
3
protease inhibitors Phase 3
4 Calpastatin Phase 3
5 Mitogens Phase 3
6
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
7
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
9 Anti-Arrhythmia Agents Phase 1, Phase 2
10 Sodium Channel Blockers Phase 1, Phase 2
11 Central Nervous System Depressants Phase 1, Phase 2
12 Diuretics, Potassium Sparing Phase 1, Phase 2
13 Gastrointestinal Agents Phase 2
14 Antiemetics Phase 2
15 Anti-Inflammatory Agents Phase 2
16 Hormone Antagonists Phase 2
17 BB 1101 Phase 2
18 Dexamethasone 21-phosphate Phase 2
19 Autonomic Agents Phase 2
20 Pharmaceutical Solutions Phase 2
21 Antineoplastic Agents, Hormonal Phase 2
22 glucocorticoids Phase 2
23 Hormones Phase 2
24
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
25
Calcium Approved, Nutraceutical 7440-70-2 271
26 Anesthetics, Local
27 Anesthetics
28 Vitamins
29 Calciferol
30 Fibrin Tissue Adhesive
31 Astragalus
32 Calcium, Dietary

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
2 Treatment of the Osgood Schlatter Disease by Immobilization ( Ankle Cruro Resin ) Versus Sporting Rest ( Reference Treatment ) : Randomized Controlled Study Unknown status NCT02824172 Phase 3
3 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
4 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
5 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
6 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
7 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
8 Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents. Completed NCT01300754 Phase 1, Phase 2
9 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
10 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
11 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
12 Repair of Articular Osteochondral Defect Unknown status NCT01409447
13 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Unknown status NCT01471236
14 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Unknown status NCT01405664
15 Mesenchymal Stem Cell Transplantation in the Treatment of Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
16 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
17 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
18 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
19 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
20 "One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions Unknown status NCT02005861
21 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
22 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
23 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis in Adolescent Girls Completed NCT03851367
24 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
25 A Prospective Investigation of Osgood Schlatter With 24 Month Follow-up Completed NCT03589001
26 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394
27 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
28 Verification and Progress of Cytokine Profiles and suPAR for the Discrimination of Infectious and Non-infectious, Degenerative Diseases of the Spine Completed NCT02554227
29 Effects of Low Frequency Neuromuscular Electrical Stimulation Applied to the Quadriceps in the Production of Knee Extension Strength and Control of Edema After Anterior Cruciate Ligament Reconstruction Completed NCT01633047
30 Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing Completed NCT00284661
31 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Recruiting NCT02397278 Platelet rich plasma (PRP)
32 Evaluation of Polymorphisms in the Vitamin D Receptor and Involved in Inflammation Associated With Vertebral Osteochondrosis Recruiting NCT04195529
33 ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee Recruiting NCT02771496
34 The Effects of Custom-made Insoles on Foot Pressure Redistribution and Spatio - Temporal Gait Parameters in Sever Disease Recruiting NCT03787316
35 A Pilot Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects of the Talus Recruiting NCT03696394
36 Evaluation of the ReNu™ Amniotic Suspension Allograft After Marrow Stimulation in the Treatment of Osteochondral Defects Recruiting NCT03036878
37 A Prospective Trial on the Clinical Efficacy of the Ankle Spacer for the Surgical Treatment of Large, Multiple, Cystic and Secondary or Tertiary Osteochondral Defects of the Talus Recruiting NCT03303690
38 Multicentric Observational Study on the Use of a Human Bone Graft in Osteochondral Defects Recruiting NCT03777735
39 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Recruiting NCT03625180
40 Detection by Digital PCR and Next Generation Sequencing of Recurrent Mutations in Waldenström's Disease and Study of Their Distribution in the Different Biological Compartments Recruiting NCT03952052
41 Focal Cartilage Defects in the Knee -A Randomized Controlled Trial Comparing Autologous Chondrocyte Implantation With Arthroscopic Debridement Recruiting NCT02636881
42 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Active, not recruiting NCT01754298
43 Retrospective Chart Analysis of Elbow Arthroscopy for the Treatment of Osteoarthritis, Radiocapitellar Plica, Lateral Epicondylitis or Osteochondritis Dissecans Active, not recruiting NCT03656185
44 Post Market, Longitudinal Data Collection Study of DeNovo NT for Articular Cartilage Defects of the Knee Active, not recruiting NCT01329445
45 A Randomized Trial Comparing Autologous Chondrocyte Implantation Using Collagen Membrane (ACI-C) Versus (Autologous Matrix Induced Chondrogenesis) AMIC for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782
46 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Active, not recruiting NCT02423629
47 MRI Findings of Epiphyseal Growth Plate in Healthy Children Enrolling by invitation NCT03190200
48 Conjoint Analysis of Patient Preferences in Joint Interventions Enrolling by invitation NCT02664337
49 Personalized Spine Study Group Registry Not yet recruiting NCT03843476
50 A Multicenter, Randomized, Pivotal Study to Evaluate the Safety and Efficacy of the Cartilage Autograft Implantation System (CAIS) for the Surgical Treatment of Articular Cartilage Lesions of the Knee Terminated NCT00881023

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel, autologous cultured chondrocytes for treatment of cartilage defects
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel) PMIDs: 17515233 17590152 16510814

Genetic Tests for Osteochondrosis

Anatomical Context for Osteochondrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

19
Bone

MalaCards organs/tissues related to Osteochondrosis:

40
Bone, Heart, Bone Marrow, Spinal Cord, Thyroid, Pituitary, Prostate

Publications for Osteochondrosis

Articles related to Osteochondrosis:

(show top 50) (show all 4369)
# Title Authors PMID Year
1
Juvenile Osteochondritis Dissecans of the Trochlea: A Cohort Study of 34 Trochlear Lesions Associated With Sporting Activities That Load the Patellofemoral Joint. 61
32028470 2020
2
Open Reduction and Internal Fixation for the Treatment of Symptomatic Osteochondritis Dissecans of the Femoral Head in Patients With Sequelae of Legg-Calvé-Perthes Disease. 61
32028473 2020
3
Description of a rare osteochondrosis lesion of the medial aspect of the distal intermediate ridge of the tibia in seven Thoroughbred horses (2008-2018). 61
32020748 2020
4
Early Results of Single-plug Autologous Osteochondral Grafting for Osteochondritis Dissecans of the Capitellum in Adolescents. 61
31923167 2020
5
Capitellar Osteochondritis Dissecans Lesions of the Elbow: A Systematic Review of Osteochondral Graft Reconstruction Options. 61
32035172 2020
6
Long-term Results of Matrix-assisted Autologous Chondrocyte Transplantation Combined With Autologous Bone Grafting for the Treatment of Juvenile Osteochondritis Dissecans. 61
31107345 2020
7
[Not a Chronic Tennis Elbow]. 61
32019453 2020
8
Cervical articular process joint osteochondrosis in Warmblood foals. 61
32009243 2020
9
Nonoperative treatment of stable juvenile osteochondritis dissecans of the knee: effectiveness of unloader bracing. 61
31774736 2020
10
Long-term Outcomes of Arthroscopic Debridement With or Without Drilling for Osteochondritis Dissecans of the Capitellum in Adolescent Baseball Players: A ≥10-year Follow-up Study. 61
32001276 2020
11
Failure of Surgery for Osteochondral Injuries of the Elbow in the Pediatric and Adolescent Population. 61
31950429 2020
12
Synovial sepsis of unknown origin in the adult Thoroughbred racehorse. 61
31006125 2020
13
A novel autologous-made matrix using hyaline cartilage chips and platelet-rich growth factors for the treatment of full-thickness cartilage or osteochondral defects: Preliminary results. 61
31835970 2020
14
Osteochondral Reconstruction of the Capitellum. 61
31739884 2020
15
Osteochondritis Dissecans in Pediatric Patients with Juvenile Idiopathic Arthritis. 61
31941802 2020
16
Proteome Alterations in Equine Osteochondrotic Chondrocytes. 61
31817880 2019
17
Freiberg's Infraction: Surgical Options. 61
31653371 2019
18
Health State Utilities in Children and Adolescents With Osteochondritis Dissecans of the Knee. 61
31840031 2019
19
Condylar Destruction in an 8-Year-Old Girl After Osteochondritis Dissecans. 61
31931954 2019
20
The Influence of Physeal Status on Rate of Reoperation After Arthroscopic Screw Fixation for Symptomatic Osteochondritis Dissecans of the Knee. 61
31870748 2019
21
Epidemiology, Injury Patterns, and Treatment of Meniscal Tears in Pediatric Patients: A 16-Year Experience of a Single Center. 61
31903403 2019
22
Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. 61
31797146 2019
23
Pediatric musculoskeletal ultrasound: a pictorial essay. 61
30414082 2019
24
Computed tomographic development of physeal osteochondrosis in pigs. 61
31847840 2019
25
Arthroscopic Dorsal Closing-Wedge Osteotomy of Metatarsal Head for Management of Freiberg Infraction. 61
31890497 2019
26
Osteochondritis Dissecans of the Elbow in Children: MRI Findings of Instability. 61
31461319 2019
27
The Treatment of Adult Osteochondritis Dissecans with Autologous Cartilage Implantation: A Systematic Review. 61
30396204 2019
28
Management of loose osteochondritis dissecans in an adolescent. 61
31708639 2019
29
Biomechanical modeling of deep squatting: Effects of the interface contact between posterior thigh and shank. 61
31558308 2019
30
Internal Fixation of Osteochondritis Dissecans of the Knee Leads to Good Long-Term Outcomes and High Degree of Healing without Differences between Fixation Devices. 61
31717628 2019
31
Editorial Commentary: "Elbow-to-Elbow" Capitellar Osteochondral Autologous Transplantation for Osteochondritis Dissecans-Are We Closer to the Holy Grail of Osteochondral Graft? 61
31699254 2019
32
Histologic Analysis of 2 Alternative Donor Sites of the Ipsilateral Elbow in the Treatment of Capitellar Osteochondritis Dissecans. 61
31699253 2019
33
Imaging of osteochondrosis. 61
31686167 2019
34
The diagnostic value of soluble urokinase-type plasminogen activator receptor (suPAR) for the discrimination of vertebral osteomyelitis and degenerative diseases of the spine. 61
31727136 2019
35
Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus. 61
31370694 2019
36
[Differential diagnoses of osteonecrosis of large joints]. 61
31642951 2019
37
Perspective on Idiopathic Subchondral, Osteochondral, and Chondral Lesions with Emphasis on the Knee. 61
31556088 2019
38
Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans. 61
31115932 2019
39
[HYBRID OSTEOCHONDRAL TRANSPLANTATION - A NEW METHOD FOR SURGICAL TREATMENT OF OSTEOCHONDRITIS DISSECANS OF THE KNEE JOINT]. 61
31804190 2019
40
Donor Site Evaluation After Osteochondral Autograft Transplantation for Capitellar Osteochondritis Dissecans. 61
31503508 2019
41
Encouraging mid-term outcomes for arthroscopic autologous osteochondral transplant (OAT) in capitellum osteochondritis dissecans (OCD). 61
31236634 2019
42
Predictive factors for developing osteochondritis dissecans after surgery for discoid lateral meniscus are younger age and shorter meniscal width. 61
31642945 2019
43
Allogenic umbilical cord blood-derived mesenchymal stem cells implantation for the treatment of juvenile osteochondritis dissecans of the knee. 61
31700204 2019
44
Closed-Wedge Osteotomy of the Distal Humerus for Treating Osteochondritis Dissecans of the Capitellum in Young Patients. 61
31696130 2019
45
Utility of Bioabsorbable Fixation of Osteochondral Lesions in the Adolescent Knee: Outcomes Analysis With Minimum 2-Year Follow-up. 61
31696131 2019
46
What are the prevalence and risk factors for repeat ipsilateral knee arthroscopy? 61
30656373 2019
47
Arthroscopic Fixation of Osteochondritis Dissecans of the Knee Using a Motorized Pick and Headless Compression Screws. 61
31921583 2019
48
Plica Syndrome and Bilateral Osteochondritis Dissecans. 61
31570077 2019
49
Evaluation criteria for the assessment of occupational diseases of the lumbar spine - how reliable are they? 61
31656177 2019
50
Osteonecrosis of the Upper Extremity: MRI-Based Zonal Patterns and Differential Diagnosis. 61
31556087 2019

Variations for Osteochondrosis

Expression for Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for Osteochondrosis

Pathways related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 TGFB1 OSM IGF2 IGF1 COL9A3 COL2A1
2
Show member pathways
13.21 TGFB1 COL9A3 COL2A1 COL24A1 COL10A1 CD36
3
Show member pathways
12.75 TGFB1 IGF2 IGF1 COL9A3 COL2A1 COL24A1
4
Show member pathways
12.35 TGFB1 MMP16 COL9A3 COL2A1 COL24A1 COL10A1
5 11.79 TGFB1 OSM NR3C1 IGF1
6 11.78 TGFB1 OSM CD36
7 11.74 TGFB1 IGF1 COL10A1
8 11.5 TGFB1 IGF1 CD36
9 11.41 MMP16 IGF2 IGF1 COL2A1
10 11.39 TGFB1 COL9A3 ACAN
11 11.33 TGFB1 IGF2 IGF1
12 11.23 VDR NR3C1 IGF1
13 10.91 TGFB1 IGF2 IGF1 COL2A1 COL10A1 ACAN
14 10.66 VDR TGFB1
15 10.51 TGFB1 OSM IGF2 IGF1 COL9A3 COL2A1

GO Terms for Osteochondrosis

Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.06 TGFB1 OSM MMP16 IGF2 IGF1 GALNS
2 extracellular space GO:0005615 9.96 TGFB1 OSM MMP16 IGF2 IGF1 COL9A3
3 endoplasmic reticulum lumen GO:0005788 9.73 COL9A3 COL2A1 COL24A1 COL10A1
4 collagen-containing extracellular matrix GO:0062023 9.63 TGFB1 COL9A3 COL2A1 COL24A1 COL10A1 ACAN
5 Golgi lumen GO:0005796 9.58 TGFB1 MMP16 ACAN
6 platelet alpha granule lumen GO:0031093 9.54 TGFB1 IGF2 IGF1
7 collagen trimer GO:0005581 9.35 COL9A3 COL2A1 COL24A1 COL10A1 CD36
8 extracellular matrix GO:0031012 9.17 TGFB1 MMP16 COL9A3 COL2A1 COL24A1 COL10A1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.65 MMP16 IGF2 COL2A1
2 extracellular matrix organization GO:0030198 9.63 MMP16 COL9A3 COL2A1 COL24A1 COL10A1 ACAN
3 platelet degranulation GO:0002576 9.62 TGFB1 IGF2 IGF1 CD36
4 positive regulation of MAPK cascade GO:0043410 9.56 OSM IGF2 IGF1 CD36
5 positive regulation of cell division GO:0051781 9.54 TGFB1 OSM IGF2
6 positive regulation of glycogen biosynthetic process GO:0045725 9.51 IGF2 IGF1
7 positive regulation of transcription regulatory region DNA binding GO:2000679 9.49 TGFB1 IGF1
8 intestinal absorption GO:0050892 9.46 VDR CD36
9 keratan sulfate catabolic process GO:0042340 9.43 GALNS ACAN
10 cell activation GO:0001775 9.4 TGFB1 IGF1
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.35 TGFB1 OSM IGF2 IGF1 CD36
12 skeletal system development GO:0001501 9.17 VDR MMP16 IGF2 IGF1 COL2A1 COL10A1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 TGFB1 OSM IGF2 IGF1
2 extracellular matrix structural constituent GO:0005201 9.35 COL9A3 COL2A1 COL24A1 COL10A1 ACAN
3 insulin-like growth factor receptor binding GO:0005159 9.26 IGF2 IGF1
4 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.92 COL9A3 COL2A1 COL24A1 COL10A1

Sources for Osteochondrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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