MCID: OST016
MIFTS: 56

Osteochondrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Osteochondrosis

MalaCards integrated aliases for Osteochondrosis:

Name: Osteochondrosis 39 12 54 15 17 74
Osteochondritis 12 77 74
Osteochondritis Juvenilis 12 74
Apophysitis 12 74
Epiphysitis 12 74
Juvenile Osteochondrosis of Tibial Tubercle 74
Epiphyseal Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8125
ICD9CM 36 732.6
MeSH 45 D055034
NCIt 51 C34879
SNOMED-CT 69 19579005 65477003
ICD10 34 M92 M93.9

Summaries for Osteochondrosis

Disease Ontology : 12 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis, is related to osteoporosis and short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans. An important gene associated with Osteochondrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Anesthetics and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Osteochondritis is a painful type of osteochondrosis where the cartilage or bone in a joint is... more...

Related Diseases for Osteochondrosis

Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 391)
# Related Disease Score Top Affiliating Genes
1 osteoporosis 29.6 CD36 IGF1 NR3C1 TGFB1 VDR
2 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.7
3 multiple epiphyseal dysplasia 12.6
4 familial osteochondritis dissecans 12.6
5 epiphyseal dysplasia, multiple, 4 12.6
6 epiphyseal dysplasia, multiple, 2 12.5
7 epiphyseal dysplasia, multiple, 5 12.5
8 epiphyseal dysplasia, multiple, 1 12.4
9 epiphyseal dysplasia, multiple, 3 12.4
10 epiphyseal dysplasia, multiple, 6 12.4
11 epiphyseal dysplasia, multiple, with myopia and conductive deafness 12.3
12 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 12.3
13 epiphyseal dysplasia, microcephaly, and nystagmus 12.3
14 epiphyseal dysplasia, multiple, 7 12.3
15 epiphyseal chondrodysplasia, miura type 12.3
16 brachyolmia type 4 with mild epiphyseal and metaphyseal changes 12.3
17 deafness, epiphyseal dysplasia, short stature 12.2
18 multiple epiphyseal dysplasia due to collagen 9 anomaly 12.2
19 legg-calve-perthes disease 12.2
20 slipped femoral capital epiphyses 12.1
21 scheuermann disease 12.1
22 multiple epiphyseal dysplasia, recessive 12.1
23 multiple epiphyseal dysplasia with robin phenotype 12.0
24 metaphyseal chondrodysplasia with cone-shaped epiphyses, normal hair, and normal hands 12.0
25 kohler's disease 12.0
26 al-gazali-bakalinova syndrome 12.0
27 growth retardation, deafness, femoral epiphyseal dysplasia, and lacrimal duct obstruction 12.0
28 epiphyseal dysplasia, multiple, with severe proximal femoral dysplasia 12.0
29 epiphyseal dysplasia, multiple, with miniepiphyses 12.0
30 epiphyseal dysplasia hearing loss dysmorphism 12.0
31 metaphyseal acroscyphodysplasia 12.0
32 skeletal dysplasia with delayed epiphyseal and carpal bone ossification 11.9
33 epiphyseal dysplasia of femoral head, myopia, and deafness 11.9
34 epiphyseal dysplasia, baumann type 11.9
35 multiple epiphyseal dysplasia, autosomal dominant 11.9
36 deafness goiter stippled epiphyses 11.9
37 epiphyseal dysplasia dysmorphism camptodactyly 11.9
38 narrow oral fissure short stature cone shaped epiphyses 11.9
39 blount's disease 11.9
40 panner disease 11.9
41 otospondylomegaepiphyseal dysplasia, autosomal recessive 11.8
42 angel-shaped phalangoepiphyseal dysplasia 11.8
43 pacman dysplasia 11.7
44 osgood-schlatter's disease 11.7
45 even-plus syndrome 11.6
46 otospondylomegaepiphyseal dysplasia 11.5
47 trichorhinophalangeal syndrome, type i 11.5
48 acrocapitofemoral dysplasia 11.5
49 spondyloepimetaphyseal dysplasia, micromelic 11.4
50 spondyloepiphyseal dysplasia congenita 11.4

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

GenomeRNAi Phenotypes related to Osteochondrosis according to GeneCards Suite gene sharing:

27 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.58 SEMA3D
2 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.58 CD36
3 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 NR3C1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 CD36 NR3C1 SEMA3D
5 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 NR3C1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 CD36 NR3C1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.58 CD36
8 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.58 CD36
9 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.58 CD36
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.58 CD36
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 CD36
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 SEMA3D
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.58 SEMA3D
14 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.58 NR3C1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.58 SEMA3D

MGI Mouse Phenotypes related to Osteochondrosis:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.31 CD36 COL24A1 COL2A1 GNPTAB IGF1 IGF2
2 behavior/neurological MP:0005386 10.29 CD36 COL24A1 COL2A1 GNPTAB IGF2 MMP16
3 cardiovascular system MP:0005385 10.28 CD36 COL2A1 IGF1 IGF2 IHH NR3C1
4 cellular MP:0005384 10.27 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
5 digestive/alimentary MP:0005381 10.21 CD36 COL2A1 GNPTAB IGF2 IHH MMP16
6 homeostasis/metabolism MP:0005376 10.21 CD36 COL2A1 GNPTAB IGF1 IGF2 NR3C1
7 endocrine/exocrine gland MP:0005379 10.15 CD36 GNPTAB IGF1 IGF2 IHH NR3C1
8 immune system MP:0005387 10.15 CD36 COL2A1 GNPTAB IGF1 IGF2 NR3C1
9 mortality/aging MP:0010768 10.14 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
10 hematopoietic system MP:0005397 10.13 CD36 GNPTAB IGF1 IGF2 NR3C1 TBXAS1
11 craniofacial MP:0005382 10.11 COL2A1 GNPTAB IGF2 IHH MMP16 TGFB1
12 integument MP:0010771 10.02 GNPTAB IGF1 IGF2 NR3C1 TGFB1 VDR
13 muscle MP:0005369 10.02 CD36 GNPTAB IGF1 IGF2 IHH NR3C1
14 nervous system MP:0003631 9.97 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
15 limbs/digits/tail MP:0005371 9.93 COL2A1 IGF1 IGF2 IHH MMP16 VDR
16 liver/biliary system MP:0005370 9.91 CD36 COL2A1 IGF2 NR3C1 TGFB1 XIRP2
17 renal/urinary system MP:0005367 9.86 CD36 COL2A1 GNPTAB IGF1 IGF2 NR3C1
18 respiratory system MP:0005388 9.7 COL2A1 GNPTAB IGF1 IGF2 IHH NR3C1
19 skeleton MP:0005390 9.65 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
20 vision/eye MP:0005391 9.1 CD36 COL2A1 GNPTAB IGF2 IHH TGFB1

Drugs & Therapeutics for Osteochondrosis

Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2, Phase 3,Phase 1
2 Fibrin Tissue Adhesive Phase 2, Phase 3
3
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
4 Diuretics, Potassium Sparing Phase 1, Phase 2
5 Anesthetics, Local Phase 1, Phase 2
6 Anti-Arrhythmia Agents Phase 1, Phase 2
7 Sodium Channel Blockers Phase 1, Phase 2
8 Central Nervous System Depressants Phase 1, Phase 2
9 Peripheral Nervous System Agents Phase 1, Phase 2
10
Calcium Approved, Nutraceutical 7440-70-2 271
11 Astragalus Not Applicable
12 Calcium, Dietary

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Treatment of the Osgood Schlatter Unknown status NCT02824172 Phase 3
2 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
3 Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial Completed NCT00560664 Phase 3
4 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
5 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379 Not Applicable
6 Osteochondritis Dissecans of the Knee Unknown status NCT01455987
7 Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression Unknown status NCT02289976 Not Applicable
8 Cytokine Profiles in Spondylodiscitis Unknown status NCT02554227
9 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis Completed NCT03851367 Not Applicable
10 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394 Not Applicable
11 Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee Completed NCT03385642
12 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
13 Post-Operative Rehabilitation of Knee Osteochondral Defect: A Case Series Completed NCT03452098
14 Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee Recruiting NCT01754298 Not Applicable
15 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Recruiting NCT02397278 Not Applicable Platelet rich plasma (PRP)
16 Human Bone Graft for Fixation of Osteochondral Defects in the Knee Joint Recruiting NCT03777735
17 An Observational, Prospective Study of Patients With Chondral and/or Osteochondral Defects of the Knee Treated With NAMIC Recruiting NCT03625180
18 AS: Ankle Spacer for Talar Osteochondral Defects Recruiting NCT03303690 Not Applicable
19 ReNu™ Marrow Stimulation Augmentation Recruiting NCT03036878 Not Applicable
20 24 Month Follow-up of Patients With Osgood Schlatter (OSD) Active, not recruiting NCT03589001
21 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects Active, not recruiting NCT02423629 Not Applicable
22 A Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects Not yet recruiting NCT03696394 Not Applicable
23 Personalized Spine Study Group Registry Not yet recruiting NCT03843476
24 A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects Terminated NCT01209390
25 Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee Withdrawn NCT02308358
26 Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy Withdrawn NCT01631409 Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;Aspirin, Isosorbide mononitrate, Atenolol, Enalapril

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel�, autologous cultured chondrocytes for treatment of cartilage defects
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel�) PMIDs: 17515233 17590152 16510814

Genetic Tests for Osteochondrosis

Anatomical Context for Osteochondrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

20
Bone

MalaCards organs/tissues related to Osteochondrosis:

42
Bone, Bone Marrow, Testes

Publications for Osteochondrosis

Articles related to Osteochondrosis:

(show top 50) (show all 925)
# Title Authors Year
1
Cumulative Incidence of Osteochondritis Dissecans of the Capitellum in Preadolescent Baseball Players. ( 30611367 )
2019
2
Editorial Commentary: "There's No Crying in Baseball," But There Is Osteochondritis Dissecans of the Elbow. ( 30611368 )
2019
3
Osteochondritis dissecans lesions of the capitellum in overhead athletes: a review of current evidence and proposed treatment algorithm. ( 30645727 )
2019
4
Validity of Ultrasound Compared with Magnetic Resonance Imaging in Evaluation of Osteochondritis Dissecans of the Distal Femur in Children. ( 30704293 )
2019
5
Osteochondritis dissecans (OCD) in Horses - Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy. ( 30796679 )
2019
6
Predictive Role of Symptom Duration Before the Initial Clinical Presentation of Adolescents With Capitellar Osteochondritis Dissecans on Preoperative and Postoperative Measures: A Systematic Review. ( 30800689 )
2019
7
Extra-articular, Intraepiphyseal Drilling for Osteochondritis Dissecans of the Knee: Characterization of a Safe and Reproducible Surgical Approach. ( 30834281 )
2019
8
Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13. ( 30857162 )
2019
9
Treatment of Osteochondritis Dissecans of the Knee with Autologous Iliac Bone Graft and Hyaluronic Acid Scaffold. ( 30893993 )
2019
10
SNP-based heritability and genetic architecture of tarsal osteochondrosis in North American Standardbred horses. ( 30353927 )
2019
11
Persisting Isolated Metacarpal Swelling and Pain in Adolescence: Consider Osteochondrosis. ( 30853202 )
2019
12
Fifty years of osteochondrosis. ( 29956851 )
2018
13
Genetic risk factors for osteochondrosis in various horse breeds. ( 29498750 )
2018
14
Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. ( 29373573 )
2018
15
Differences between horse selection based on two forms of osteochondrosis in fetlock. ( 29524049 )
2018
16
Septic Arthritis/Osteomyelitis May Lead to Osteochondrosis-Like Lesions in Foals. ( 29807507 )
2018
17
Treatment of Osteochondrosis Dissecans of the Canine Stifle Using Synthetic Osteochondral Resurfacing. ( 29534283 )
2018
18
Osteochondritis dissecans shows a severe course and poor outcome in patients with juvenile idiopathic arthritis: a matched pair study of 22 cases. ( 29992441 )
2018
19
Osteochondritis Dissecans in the Knee of Skeletally Immature Patients: Rates of Persistent Pain, Osteoarthritis, and Arthroplasty at Mean 14-Years' Follow-Up. ( 29998745 )
2018
20
Sustained Results in Long-Term Follow-Up of Autologous Chondrocyte Implantation (ACI) for Distal Femur Juvenile Osteochondritis Dissecans (JOCD). ( 30345118 )
2018
21
The Treatment of Adult Osteochondritis Dissecans with Autologous Cartilage Implantation: A Systematic Review. ( 30396204 )
2018
22
Outcomes of surgical treatment for osteochondritis dissecans of the elbow: evaluation by lesion location. ( 30446232 )
2018
23
The relation between ankle morphology and osteochondritis dissecans of talus. ( 30462607 )
2018
24
Treatment of unstable knee osteochondritis dissecans in the young adult: results and limitations of surgical strategies-The advantages of allografts to address an osteochondral challenge. ( 30523367 )
2018
25
Unstable Osteochondritis Dissecans of the Glenoid Fixed with Autogenous Osteochondral Plugs in a College Baseball Player: A Case Report. ( 30540608 )
2018
26
Identification of Areas of Epiphyseal Cartilage Necrosis at Predilection Sites of Juvenile Osteochondritis Dissecans in Pediatric Cadavers. ( 30562294 )
2018
27
Demographics and Epidemiology of Osteochondritis Dissecans of the Elbow Among Children and Adolescents. ( 30622996 )
2018
28
Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold. ( 30671478 )
2018
29
Osteochondritis dissecans of the capitellum secondary to fishtail deformity treated with osteochondral autograft. ( 30675580 )
2018
30
Characterization of cellular and matrix alterations in the early pathogenesis of osteochondritis dissecans in pigs using second harmonic generation and two-photon excitation fluorescence microscopy. ( 29460985 )
2018
31
Osteochondritis Dissecans of the Knee - Conservative Treatment Strategies: A Systematic Review. ( 29468901 )
2018
32
Variation in stress distribution patterns across the radial head fovea in osteochondritis dissecans: predictive factors in radiographic findings. ( 29477668 )
2018
33
Is there any difference between open and arthroscopic treatment for osteochondritis dissecans of the humeral capitellum? ( 29546608 )
2018
34
Management of Osteochondritis Dissecans of the Femoral Condyle: A Critical Analysis Review. ( 29557795 )
2018
35
Incidence of Osteochondritis Dissecans in Adults. ( 29613834 )
2018
36
Internal Fixation of Unstable Osteochondritis Dissecans: Do Open Growth Plates Improve Healing Rate? ( 29995442 )
2018
37
Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study. ( 29998134 )
2018
38
Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review. ( 29998741 )
2018
39
Osteochondritis dissecans of the trochlea: case report. ( 30027086 )
2018
40
"The quiet necrosis": An early medieval case of multifocal juvenile osteochondritis dissecans of the knee. ( 30077620 )
2018
41
Grade I Osteochondritis Dissecans in a Young Professional Athlete. ( 30078890 )
2018
42
OSTEOCHONDRITIS DISSECANS OF THE RADIAL HEAD IN A YOUNG ATHLETE: A CASE REPORT. ( 30140566 )
2018
43
Osteochondritis Dissecans of the Knee: Short-Term Outcomes of a Hybrid Technique to Restore a Partially Salvageable Progeny Fragment. ( 30141694 )
2018
44
Decreased Defect Size and Partial Restoration of Subchondral Bone on Computed Tomography After Arthroscopic Debridement and Microfracture for Osteochondritis Dissecans of the Capitellum. ( 30141965 )
2018
45
Osteochondritis Dissecans Lesion of the Radial Head. ( 30180223 )
2018
46
OSTEOCHONDRAL AUTOGRAFT TRANSFER FOR TREATMENT OF STIFLE OSTEOCHONDRITIS DISSECANS IN TWO RELATED SNOW LEOPARDS ( PANTHERA UNCIA). ( 30212335 )
2018
47
Arthroscopic Meniscopexy for the Treatment of Nontraumatic Osteochondritis Dissecans in the Knee Joint of Adult Patients. ( 30221986 )
2018
48
A Magnetic Resonance Imaging-Based Staging System for Osteochondritis Dissecans of the Elbow: A Validation Study Against the International Cartilage Repair Society Classification. ( 30225272 )
2018
49
Treatment of Capitellar Osteochondritis Dissecans With a Novel Regenerative Technique: Case Report of 3 Patients After 4 Years. ( 30228993 )
2018
50
Bone Peg Grafting for Capitellar Osteochondritis Dissecans in Adolescent Baseball Players. ( 30233980 )
2018

Variations for Osteochondrosis

Expression for Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for Osteochondrosis

GO Terms for Osteochondrosis

Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 COL24A1 COL2A1 IGF1 IGF2 IHH MMP16
2 extracellular space GO:0005615 9.56 CD36 COL24A1 COL2A1 IGF1 IGF2 IHH
3 platelet alpha granule lumen GO:0031093 9.33 IGF1 IGF2 TGFB1
4 extracellular matrix GO:0031012 9.02 COL24A1 COL2A1 IHH MMP16 TGFB1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.96 CD36 IGF2 NR3C1 TGFB1 VDR
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 IGF1 IGF2 IHH NR3C1 TGFB1 VDR
3 positive regulation of gene expression GO:0010628 9.88 CD36 IGF1 TGFB1 VDR
4 positive regulation of MAPK cascade GO:0043410 9.72 CD36 IGF1 IGF2
5 cellular response to amyloid-beta GO:1904646 9.61 CD36 IGF1
6 positive regulation of activated T cell proliferation GO:0042104 9.61 IGF1 IGF2
7 ossification GO:0001503 9.61 COL2A1 IGF2 IHH
8 positive regulation of mitotic nuclear division GO:0045840 9.6 IGF1 IGF2
9 endochondral ossification GO:0001958 9.59 COL2A1 MMP16
10 positive regulation of collagen biosynthetic process GO:0032967 9.58 IHH TGFB1
11 cell-cell junction organization GO:0045216 9.57 TGFB1 XIRP2
12 response to fatty acid GO:0070542 9.54 CD36 TBXAS1
13 positive regulation of glycogen biosynthetic process GO:0045725 9.52 IGF1 IGF2
14 positive regulation of transcription regulatory region DNA binding GO:2000679 9.51 IGF1 TGFB1
15 intestinal absorption GO:0050892 9.49 CD36 VDR
16 cell activation GO:0001775 9.46 IGF1 TGFB1
17 platelet degranulation GO:0002576 9.46 CD36 IGF1 IGF2 TGFB1
18 positive regulation of epithelial cell proliferation GO:0050679 9.43 IGF1 IHH TGFB1
19 chondrocyte proliferation GO:0035988 9.4 IHH MMP16
20 morphogenesis of a branching structure GO:0001763 9.37 IHH TGFB1
21 proteoglycan metabolic process GO:0006029 9.32 COL2A1 IHH
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 CD36 IGF1 IGF2 TGFB1
23 skeletal system development GO:0001501 9.02 COL2A1 IGF1 IGF2 IHH VDR

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IGF1 IGF2 TGFB1
2 protein serine/threonine kinase activator activity GO:0043539 9.26 IGF2 TGFB1
3 insulin receptor binding GO:0005158 8.96 IGF1 IGF2
4 insulin-like growth factor receptor binding GO:0005159 8.62 IGF1 IGF2

Sources for Osteochondrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....