MCID: OST016
MIFTS: 55

Osteochondrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Osteochondrosis

MalaCards integrated aliases for Osteochondrosis:

Name: Osteochondrosis 12 53 59 15 38 17 72
Osteochondritis 12 75 72
Osteochondritis Juvenilis 12 72
Apophysitis 12 72
Epiphysitis 12 72
Juvenile Osteochondrosis of Tibial Tubercle 72
Epiphyseal Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8125
ICD9CM 35 732.6
MeSH 44 D055034
NCIt 50 C34879
SNOMED-CT 68 19579005 65477003
ICD10 33 M92 M93.9
ICD10 via Orphanet 34 M93.9
UMLS via Orphanet 73 C0029429
Orphanet 59 ORPHA399319
UMLS 72 C0014574 C0029376 C0029420 more

Summaries for Osteochondrosis

Disease Ontology : 12 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis, is related to bone disease and osteoporosis. An important gene associated with Osteochondrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Proteoglycans in cancer and Adipogenesis. The drugs Mitogens and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are cardiovascular system and cellular

Wikipedia : 75 Osteochondritis is a painful type of osteochondrosis where the cartilage or bone in a joint is... more...

Related Diseases for Osteochondrosis

Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 697)
# Related Disease Score Top Affiliating Genes
1 bone disease 30.1 VDR IGF1 COL2A1 CD36
2 osteoporosis 29.6 VDR TGFB1 NR3C1 IGF1 CD36
3 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.8
4 multiple epiphyseal dysplasia 12.8
5 familial osteochondritis dissecans 12.8
6 epiphyseal dysplasia, multiple, 4 12.7
7 epiphyseal dysplasia, multiple, 5 12.7
8 epiphyseal dysplasia, multiple, 1 12.7
9 epiphyseal dysplasia, multiple, 3 12.7
10 epiphyseal dysplasia, multiple, 2 12.7
11 epiphyseal dysplasia, multiple, 6 12.6
12 epiphyseal dysplasia, multiple, with myopia and conductive deafness 12.6
13 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 12.6
14 epiphyseal chondrodysplasia, miura type 12.5
15 epiphyseal dysplasia, microcephaly, and nystagmus 12.5
16 epiphyseal dysplasia, multiple, 7 12.5
17 brachyolmia type 4 with mild epiphyseal and metaphyseal changes 12.4
18 deafness, epiphyseal dysplasia, short stature 12.4
19 scheuermann disease 12.4
20 legg-calve-perthes disease 12.3
21 multiple epiphyseal dysplasia due to collagen 9 anomaly 12.3
22 multiple epiphyseal dysplasia with robin phenotype 12.3
23 metaphyseal chondrodysplasia with cone-shaped epiphyses, normal hair, and normal hands 12.3
24 slipped femoral capital epiphyses 12.3
25 multiple epiphyseal dysplasia, recessive 12.3
26 growth retardation, deafness, femoral epiphyseal dysplasia, and lacrimal duct obstruction 12.2
27 multiple epiphyseal dysplasia, autosomal dominant 12.2
28 osteochondrosis of genetic origin 12.2
29 multiple epiphyseal dysplasia and pseudoachondroplasia 12.2
30 epiphyseal dysplasia of femoral head, myopia, and deafness 12.2
31 epiphyseal dysplasia, baumann type 12.2
32 kohler's disease 12.2
33 panner disease 12.1
34 al-gazali-bakalinova syndrome 12.1
35 epiphyseal dysplasia, multiple, with severe proximal femoral dysplasia 12.1
36 epiphyseal dysplasia, multiple, with miniepiphyses 12.1
37 epiphyseal dysplasia hearing loss dysmorphism 12.1
38 metaphyseal acroscyphodysplasia 12.1
39 skeletal dysplasia with delayed epiphyseal and carpal bone ossification 12.1
40 deafness goiter stippled epiphyses 12.1
41 epiphyseal dysplasia dysmorphism camptodactyly 12.1
42 obsolete: localized epiphyseal dysplasia 12.1
43 obsolete: multiple epiphyseal dysplasia, unclassified type 12.1
44 blount's disease 12.0
45 pacman dysplasia 12.0
46 otospondylomegaepiphyseal dysplasia, autosomal recessive 12.0
47 angel-shaped phalangoepiphyseal dysplasia 12.0
48 even-plus syndrome 12.0
49 osgood-schlatter's disease 11.8
50 sinding-larsen-johansson disease 11.7

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

MGI Mouse Phenotypes related to Osteochondrosis:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CD36 CLCN2 COL2A1 IGF1 IGF2 IHH
2 cellular MP:0005384 10.32 CD36 CLCN2 COL2A1 GNPTAB IGF1 IGF2
3 behavior/neurological MP:0005386 10.29 CD36 CLCN2 COL2A1 GNPTAB IGF2 MMP16
4 growth/size/body region MP:0005378 10.28 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
5 digestive/alimentary MP:0005381 10.26 CD36 CLCN2 COL2A1 GNPTAB IGF2 IHH
6 homeostasis/metabolism MP:0005376 10.22 CD36 CLCN2 COL2A1 GNPTAB IGF1 IGF2
7 endocrine/exocrine gland MP:0005379 10.2 CD36 CLCN2 GNPTAB IGF1 IGF2 IHH
8 mortality/aging MP:0010768 10.17 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
9 immune system MP:0005387 10.16 CD36 CLCN2 COL2A1 GNPTAB IGF1 IGF2
10 craniofacial MP:0005382 10.11 COL2A1 GNPTAB IGF2 IHH MMP16 TGFB1
11 nervous system MP:0003631 10.07 CD36 CLCN2 COL2A1 GNPTAB IGF1 IGF2
12 muscle MP:0005369 10.06 CD36 GNPTAB IGF1 IGF2 IHH NR3C1
13 integument MP:0010771 10.04 GNPTAB IGF1 IGF2 NR3C1 TGFB1 VDR
14 limbs/digits/tail MP:0005371 9.95 COL2A1 IGF1 IGF2 IHH MMP16 VDR
15 liver/biliary system MP:0005370 9.93 CD36 COL2A1 IGF2 NR3C1 TGFB1 XIRP2
16 renal/urinary system MP:0005367 9.92 CD36 COL2A1 GNPTAB IGF1 IGF2 NR3C1
17 reproductive system MP:0005389 9.8 CLCN2 GNPTAB IGF1 IGF2 NR3C1 TGFB1
18 respiratory system MP:0005388 9.7 COL2A1 GNPTAB IGF1 IGF2 IHH NR3C1
19 skeleton MP:0005390 9.65 CD36 COL2A1 GNPTAB IGF1 IGF2 IHH
20 vision/eye MP:0005391 9.17 CD36 CLCN2 COL2A1 GNPTAB IGF2 IHH

Drugs & Therapeutics for Osteochondrosis

Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 3
2
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
5 Sodium Channel Blockers Phase 1, Phase 2
6 Diuretics, Potassium Sparing Phase 1, Phase 2
7 Central Nervous System Depressants Phase 1, Phase 2
8 Anti-Arrhythmia Agents Phase 1, Phase 2
9 Peripheral Nervous System Agents Phase 2
10 Anti-Inflammatory Agents Phase 2
11 Gastrointestinal Agents Phase 2
12 Dexamethasone 21-phosphate Phase 2
13 Antiemetics Phase 2
14 Pharmaceutical Solutions Phase 2
15 glucocorticoids Phase 2
16 HIV Protease Inhibitors Phase 2
17
protease inhibitors Phase 2
18 Hormones Phase 2
19 Antineoplastic Agents, Hormonal Phase 2
20 Hormone Antagonists Phase 2
21 Autonomic Agents Phase 2
22 BB 1101 Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
24
Calcium Approved, Nutraceutical 7440-70-2 271
25 Anesthetics, Local
26 Anesthetics
27 Astragalus
28 Fibrin Tissue Adhesive
29 Calcium, Dietary

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
2 Treatment of the Osgood Schlatter Disease by Immobilization ( Ankle Cruro Resin ) Versus Sporting Rest ( Reference Treatment ) : Randomized Controlled Study Unknown status NCT02824172 Phase 3
3 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
4 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
5 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
6 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
7 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
8 Treatment of Osteochondral Lesion of Talus With Processed Osteochondral Allograft Unknown status NCT02736318 Phase 1, Phase 2
9 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
10 Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents. Completed NCT01300754 Phase 1, Phase 2
11 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
12 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
13 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
14 Repair of Articular Osteochondral Defect Unknown status NCT01409447
15 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Unknown status NCT01405664
16 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Unknown status NCT01471236
17 Mesenchymal Stem Cell Transplantation in the Treatment of Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
18 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
19 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
20 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
21 "One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions Unknown status NCT02005861
22 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
23 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
24 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis in Adolescent Girls Completed NCT03851367
25 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
26 A Prospective Investigation of Osgood Schlatter With 24 Month Follow-up Completed NCT03589001
27 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394
28 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
29 Verification and Progress of Cytokine Profiles and suPAR for the Discrimination of Infectious and Non-infectious, Degenerative Diseases of the Spine Completed NCT02554227
30 Effects of Low Frequency Neuromuscular Electrical Stimulation Applied to the Quadriceps in the Production of Knee Extension Strength and Control of Edema After Anterior Cruciate Ligament Reconstruction Completed NCT01633047
31 Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing Completed NCT00284661
32 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Recruiting NCT02397278 Platelet rich plasma (PRP)
33 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Recruiting NCT01754298
34 Valutazione Dell'Epidemiologia e Dei Risultati Radiografici e Clinici Nel Trattamento Artroscopico Delle Lesioni Osteocondrali Dell'Astragalo Con Tecnica AMIC Recruiting NCT03371121
35 Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results Recruiting NCT03908931
36 Conjoint Analysis of Patient Preferences in Joint Interventions Recruiting NCT02664337
37 ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee Recruiting NCT02771496
38 The Effects of Custom-made Insoles on Foot Pressure Redistribution and Spatio - Temporal Gait Parameters in Sever Disease Recruiting NCT03787316
39 A Pilot Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects of the Talus Recruiting NCT03696394
40 Evaluation of the ReNu™ Amniotic Suspension Allograft After Marrow Stimulation in the Treatment of Osteochondral Defects Recruiting NCT03036878
41 Multicentric Observational Study on the Use of a Human Bone Graft in Osteochondral Defects Recruiting NCT03777735
42 A Prospective Trial on the Clinical Efficacy of the Ankle Spacer for the Surgical Treatment of Large, Multiple, Cystic and Secondary or Tertiary Osteochondral Defects of the Talus Recruiting NCT03303690
43 Detection by Digital PCR and Next Generation Sequencing of Recurrent Mutations in Waldenström's Disease and Study of Their Distribution in the Different Biological Compartments Recruiting NCT03952052
44 Focal Cartilage Defects in the Knee -A Randomized Controlled Trial Comparing Autologous Chondrocyte Implantation With Arthroscopic Debridement Recruiting NCT02636881
45 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Recruiting NCT03625180
46 Retrospective Chart Analysis of Elbow Arthroscopy for the Treatment of Osteoarthritis, Radiocapitellar Plica, Lateral Epicondylitis or Osteochondritis Dissecans Active, not recruiting NCT03656185
47 Post Market, Longitudinal Data Collection Study of DeNovo NT for Articular Cartilage Defects of the Knee Active, not recruiting NCT01329445
48 A Randomized Trial Comparing Autologous Chondrocyte Implantation Using Collagen Membrane (ACI-C) Versus (Autologous Matrix Induced Chondrogenesis) AMIC for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782
49 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Active, not recruiting NCT01347892
50 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Active, not recruiting NCT02423629

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel, autologous cultured chondrocytes for treatment of cartilage defects
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel) PMIDs: 17515233 17590152 16510814

Genetic Tests for Osteochondrosis

Anatomical Context for Osteochondrosis

MalaCards organs/tissues related to Osteochondrosis:

41
Bone, Bone Marrow, Heart, Spinal Cord, Brain, Skin, Pituitary

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

19
Bone

Publications for Osteochondrosis

Articles related to Osteochondrosis:

(show top 50) (show all 4320)
# Title Authors PMID Year
1
Qafzeh 9 mandible (ca 90-100 kyrs BP, Israel) revisited: μ-CT and 3D reveal new pathological conditions. 38
31351220 2019
2
Osteochondrosis in the Distal Femoral Physis of Pigs Starts With Vascular Failure. 38
31060473 2019
3
[Differential diagnoses of osteonecrosis of large joints]. 38
31317211 2019
4
Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus. 38
31370694 2019
5
Osteochondritis dissecans with associated secondary chondromatosis in an adolescent shoulder. 38
31316588 2019
6
Does Internal Fixation for Unstable Osteochondritis Dissecans of the Skeletally Mature Knee Work? A Systematic Review. 38
31395194 2019
7
Editorial Commentary: Unstable Osteochondritis Dissecans in the Mature Knee: Internal Fixation Works, But We Need More Data. 38
31395195 2019
8
Diabetic bone lesions: a study on 38 known modern skeletons and the implications for forensic scenarios. 38
29860597 2019
9
Artistic Gymnastics Injuries; Epidemiology, Evaluation, and Treatment. 38
31232791 2019
10
Effects of blood-derived products and sodium hyaluronate on equine synovial fluid cells and on synovial fluid from osteochondrotic joints of horses after arthroscopy and administration of treatment. 38
31246124 2019
11
Long-term results of closed-wedge osteotomy of the lateral humeral condyle for osteochondritis dissecans of the capitellum. 38
31326338 2019
12
Synthetic osteochondral resurfacing for treatment of large caudocentral osteochondritis dissecans lesions of the humeral head in 24 dogs. 38
31115058 2019
13
Osteochondritis Dissecans of the Humeral Trochlea: Characterization of a Rare Disorder Based on 28 Cases. 38
31233330 2019
14
Osteochondritis Dissecans of the Knee - Conservative Treatment Strategies: A Systematic Review. 38
29468901 2019
15
Predictors of Unsuccessful Nonoperative Management of Capitellar Osteochondritis Dissecans. 38
31348868 2019
16
MR arthrographic evaluation of the association between anterolateral soft tissue impingement and osteochondral lesion of the tibiotalar joint. 38
30874994 2019
17
Effectiveness of Adhering Adipose-Derived Stem Cells to Defective Cartilage in Promoting Cartilage Regeneration in a Rabbit Model. 38
31307837 2019
18
Familial, long-term pollakisuria as initial manifestation of HSP4 due to the SPAST variant c.683-2A>C. 38
30962061 2019
19
Persisting Isolated Metacarpal Swelling and Pain in Adolescence: Consider Osteochondrosis. 38
30853202 2019
20
Osteochondritis dissecans (OCD) in Horses - Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy. 38
30796679 2019
21
The synovial fluid proteome differentiates between septic and nonseptic articular pathologies. 38
31028944 2019
22
Encouraging mid-term outcomes for arthroscopic autologous osteochondral transplant (OAT) in capitellum osteochondritis dissecans (OCD). 38
31236634 2019
23
Treatment of Osteochondritis Dissecans of the Knee with Autologous Iliac Bone Graft and Hyaluronic Acid Scaffold. 38
30893993 2019
24
Sufficient duration of off-season decreases elbow disorders in elementary school-aged baseball players. 38
31003885 2019
25
10-Min 3D Turbo Spin Echo MRI of the Knee in Children: Arthroscopy-Validated Accuracy for the Diagnosis of Internal Derangement. 38
30142235 2019
26
Treatment of unstable knee osteochondritis dissecans in the young adult: results and limitations of surgical strategies-The advantages of allografts to address an osteochondral challenge. 38
30523367 2019
27
Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones. 38
31083875 2019
28
Syphilis with Charcot arthropathy: A case report. 38
30758895 2019
29
Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans. 38
31115932 2019
30
Juvenile osteochondritis dissecans (JOCD) of the knee: current concepts review. 38
31191988 2019
31
Osteochondritis Dissecans of Smaller Joints: The Elbow. 38
31113206 2019
32
Long-term Results of Matrix-assisted Autologous Chondrocyte Transplantation Combined With Autologous Bone Grafting For the Treatment of Juvenile Osteochondritis Dissecans. 38
31107345 2019
33
Is It an Overlooked Injury? Magnetic Resonance Imaging Examination of Occult Talus Lesions Concomitant to Tibial Shaft Fracture. 38
30803913 2019
34
Platelet-rich plasma combined with allograft to treat osteochondritis dissecans of the knee: a case report. 38
31014387 2019
35
Imaging and classification of osteochondritis dissecans of the capitellum: X-ray, magnetic resonance imaging or computed tomography? 38
30941202 2019
36
Clinical Value of MRI in Assessing the Stability of Osteochondritis Dissecans Lesions: A Systematic Review and Meta-Analysis. 38
30995094 2019
37
Synovial sepsis of unknown origin in the adult Thoroughbred racehorse. 38
31006125 2019
38
Köhler Disease: Avascular Necrosis in the Child. 38
30685015 2019
39
Freiberg Disease and Avascular Necrosis of the Metatarsal Heads. 38
30685014 2019
40
Fragmentation of the dorsal distal aspect of the talus on weanling survey and pre-sale radiographs of juvenile Thoroughbreds: prevalence and 2- and 3-year-olds racing performance. 38
30773615 2019
41
Neither significant osteoarthritic changes nor deteriorating subjective outcomes occur after hybrid fixation of osteochondritis dissecans in the young adult. 38
29916011 2019
42
Osteochondritis dissecans lesions of the capitellum in overhead athletes: a review of current evidence and proposed treatment algorithm. 38
30645727 2019
43
Fresh Osteochondral Allograft Transplantation for Uncontained, Elongated Osteochondritis Dissecans Lesions of the Medial Femoral Condyle. 38
31019884 2019
44
Osteochondral Allograft Transplantation of the Medial Femoral Condyle With Orthobiologic Augmentation and Graft-Recipient Microfracture Preparation. 38
31016129 2019
45
Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13. 38
30857162 2019
46
SNP-based heritability and genetic architecture of tarsal osteochondrosis in North American Standardbred horses. 38
30353927 2019
47
Validity of Ultrasound Compared with Magnetic Resonance Imaging in Evaluation of Osteochondritis Dissecans of the Distal Femur in Children. 38
30704293 2019
48
Extra-articular, Intraepiphyseal Drilling for Osteochondritis Dissecans of the Knee: Characterization of a Safe and Reproducible Surgical Approach. 38
30834281 2019
49
Predictive Role of Symptom Duration Before the Initial Clinical Presentation of Adolescents With Capitellar Osteochondritis Dissecans on Preoperative and Postoperative Measures: A Systematic Review. 38
30800689 2019
50
A Technique for Arthroscopic Osteochondral Autograft Transplantation of the Hip. 38
30899659 2019

Variations for Osteochondrosis

Expression for Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for Osteochondrosis

GO Terms for Osteochondrosis

Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TGFB1 SEMA3D IHH IGF2 IGF1 COL2A1
2 extracellular matrix GO:0031012 9.26 TGFB1 MMP16 IHH COL2A1
3 platelet alpha granule lumen GO:0031093 8.8 TGFB1 IGF2 IGF1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 VDR TGFB1 NR3C1 IGF2 CD36
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 VDR TGFB1 NR3C1 IHH IGF2 IGF1
3 positive regulation of gene expression GO:0010628 9.87 VDR TGFB1 IGF1 CD36
4 positive regulation of MAPK cascade GO:0043410 9.71 IGF2 IGF1 CD36
5 cellular response to amyloid-beta GO:1904646 9.61 IGF1 CD36
6 ossification GO:0001503 9.61 IHH IGF2 COL2A1
7 positive regulation of mitotic nuclear division GO:0045840 9.6 IGF2 IGF1
8 positive regulation of activated T cell proliferation GO:0042104 9.59 IGF2 IGF1
9 endochondral ossification GO:0001958 9.58 MMP16 COL2A1
10 positive regulation of collagen biosynthetic process GO:0032967 9.58 TGFB1 IHH
11 cell-cell junction organization GO:0045216 9.56 XIRP2 TGFB1
12 positive regulation of glycogen biosynthetic process GO:0045725 9.52 IGF2 IGF1
13 positive regulation of transcription regulatory region DNA binding GO:2000679 9.51 TGFB1 IGF1
14 intestinal absorption GO:0050892 9.49 VDR CD36
15 cell activation GO:0001775 9.46 TGFB1 IGF1
16 platelet degranulation GO:0002576 9.46 TGFB1 IGF2 IGF1 CD36
17 positive regulation of epithelial cell proliferation GO:0050679 9.43 TGFB1 IHH IGF1
18 chondrocyte proliferation GO:0035988 9.4 MMP16 IHH
19 morphogenesis of a branching structure GO:0001763 9.37 TGFB1 IHH
20 proteoglycan metabolic process GO:0006029 9.32 IHH COL2A1
21 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 TGFB1 IGF2 IGF1 CD36
22 skeletal system development GO:0001501 9.02 VDR IHH IGF2 IGF1 COL2A1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 TGFB1 IGF2 IGF1
2 protein serine/threonine kinase activator activity GO:0043539 9.26 TGFB1 IGF2
3 insulin receptor binding GO:0005158 8.96 IGF2 IGF1
4 insulin-like growth factor receptor binding GO:0005159 8.62 IGF2 IGF1

Sources for Osteochondrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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