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MCID: OST016
MIFTS: 53

Osteochondrosis

Categories: Bone diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Osteochondrosis

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MalaCards integrated aliases for Osteochondrosis:

Name: Osteochondrosis 12 52 58 15 37 71
Osteochondritis 12 74 71
Osteochondritis Juvenilis 12 71
Apophysitis 12 71
Epiphysitis 12 71
Juvenile Osteochondrosis of Tibial Tubercle 71
Epiphyseal Necrosis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:8125
ICD9CM 34 732.6
MeSH 43 D055034
NCIt 49 C34879
ICD10 32 M92 M93.9
ICD10 via Orphanet 33 M93.9
UMLS via Orphanet 72 C0029429
Orphanet 58 ORPHA399319
UMLS 71 C0014574 C0029376 C0029420 more
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Summaries for Osteochondrosis

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Disease Ontology : 12 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis, is related to epiphyseal dysplasia, multiple, 4 and scheuermann disease. An important gene associated with Osteochondrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Mitogens and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Osteochondritis is a painful type of osteochondrosis where the cartilage or bone in a joint is... more...

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Related Diseases for Osteochondrosis

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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 714)
# Related Disease Score Top Affiliating Genes
1 epiphyseal dysplasia, multiple, 4 34.1 COL9A3 COL9A2 COL9A1
2 scheuermann disease 34.1 PES1 COL9A3 COL2A1
3 epiphyseal dysplasia, multiple, 5 34.1 COL9A3 COL9A2 COL9A1
4 epiphyseal dysplasia, multiple, 1 34.0 COL9A3 COL9A2 COL9A1
5 epiphyseal dysplasia, multiple, 3 34.0 COL9A3 COL9A2 COL9A1
6 epiphyseal dysplasia, multiple, 2 34.0 COL9A3 COL9A2 COL9A1
7 epiphyseal dysplasia, multiple, 6 34.0 COL9A3 COL9A2 COL9A1
8 multiple epiphyseal dysplasia 33.8 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
9 kohler's disease 33.8 PES1 HECTD4 COL2A1
10 legg-calve-perthes disease 33.6 GALNS COL9A1 COL2A1
11 multiple epiphyseal dysplasia due to collagen 9 anomaly 33.5 COL9A3 COL9A2 COL9A1
12 osgood-schlatter's disease 33.4 PES1 HECTD4
13 multiple epiphyseal dysplasia, autosomal dominant 33.3 COL9A3 COL9A2 COL9A1
14 achilles bursitis 32.9 PES1 HECTD4
15 otospondylomegaepiphyseal dysplasia, autosomal recessive 32.7 COL9A3 COL9A2 COL9A1 COL2A1
16 spondyloepiphyseal dysplasia congenita 32.2 GALNS COL9A3 COL9A1 COL2A1
17 pseudoachondroplasia 31.6 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
18 spondyloepiphyseal dysplasia with congenital joint dislocations 31.4 GALNS COL9A2 COL9A1 COL2A1 ACAN
19 spondyloepimetaphyseal dysplasia, matrilin-3 related 31.4 GALNS COL9A3 COL9A2 COL9A1 COL2A1 ACAN
20 achondroplasia 30.9 IGF1 COL2A1 ACAN
21 odontochondrodysplasia 30.8 PES1 IGF1 GALNS COL9A3 COL9A2 COL9A1
22 arthropathy 30.8 IGF1 COL2A1 ACAN
23 back pain 30.6 COL9A3 COL9A2
24 osteoarthritis 30.6 TGFB1 IGF1 COL9A1 COL2A1 ACAN
25 osteochondritis dissecans 30.6 COL9A3 COL9A2 COL9A1 COL2A1 CD36 ACAN
26 degenerative disc disease 30.5 VDR COL9A3 ACAN
27 brittle bone disorder 30.5 COL2A1 CD36 ACAN
28 otosclerosis 30.5 VDR TGFB1 CD36
29 epicondylitis 30.4 PES1 HECTD4 ACAN
30 exostosis 30.4 PES1 HECTD4 COL2A1 ACAN
31 parathyroid adenoma 30.4 VDR TGFB1 IGF1
32 scoliosis 30.4 VDR TGFB1 IGF1 COL2A1 ACAN
33 peroneal nerve paralysis 30.4 PES1 HECTD4 COL2A1
34 bone disease 30.4 VDR IGF1 COL2A1 CD36 ACAN
35 bone resorption disease 30.3 VDR IGF1 HECTD4
36 chondromalacia 30.3 PES1 ACAN
37 diastrophic dysplasia 30.2 COL9A3 COL9A2 COL9A1 COL2A1
38 spondylolisthesis 30.2 HECTD4 COL9A3 ACAN
39 atelosteogenesis 30.1 COL9A3 COL9A2 COL9A1
40 vitreoretinal degeneration 30.1 COL9A2 COL2A1
41 reflex sympathetic dystrophy 29.9 HECTD4 CD36
42 osteoporosis 29.9 VDR TGFB1 NR3C1 IGF2 IGF1 COL2A1
43 stickler syndrome 29.8 COL9A3 COL9A2 COL9A1 COL2A1
44 achondrogenesis 29.7 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
45 strabismus 29.7 PES1 HECTD4 COL9A1 COL2A1
46 clubfoot 29.6 PES1 HECTD4 COL9A2 COL9A1 COL2A1
47 spinal stenosis 29.6 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
48 retinal detachment 29.6 TGFB1 IGF1 COL9A2 COL9A1 COL2A1
49 myopia 29.6 TGFB1 IGF1 COL9A2 COL9A1 COL2A1 ACAN
50 bone inflammation disease 29.5 HECTD4 COL2A1 ACAN

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis
Sources

Symptoms & Phenotypes for Osteochondrosis

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GenomeRNAi Phenotypes related to Osteochondrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.62 NR3C1
2 Decreased viability GR00240-S-1 9.62 CD36
3 Decreased viability GR00249-S 9.62 CD36 COL9A1 HECTD4 OSM TGFB1
4 Decreased viability GR00381-A-1 9.62 COL9A3 PES1
5 Decreased viability GR00381-A-2 9.62 COL9A3
6 Decreased viability GR00381-A-3 9.62 COL9A3
7 Decreased viability GR00386-A-1 9.62 CCDC90B CD36 GALNS PES1 VDR
8 Decreased viability GR00402-S-2 9.62 COL9A2 COL9A3 GALNS PES1

MGI Mouse Phenotypes related to Osteochondrosis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 CD36 CLCN2 COL24A1 COL2A1 COL9A2 GNPTAB
2 cellular MP:0005384 10.24 CD36 CLCN2 COL2A1 COL9A1 GALNS GNPTAB
3 homeostasis/metabolism MP:0005376 10.18 CD36 CLCN2 COL2A1 COL9A1 GALNS GNPTAB
4 digestive/alimentary MP:0005381 10.11 CD36 CLCN2 COL2A1 GNPTAB IGF2 MMP16
5 immune system MP:0005387 10.1 CD36 CLCN2 COL2A1 COL9A1 COL9A3 GNPTAB
6 endocrine/exocrine gland MP:0005379 10.09 CD36 CLCN2 COL9A3 GNPTAB IGF1 IGF2
7 craniofacial MP:0005382 10.02 COL2A1 GNPTAB IGF2 MMP16 PES1 TGFB1
8 hearing/vestibular/ear MP:0005377 9.88 COL2A1 COL9A1 COL9A2 COL9A3 IGF1 VDR
9 renal/urinary system MP:0005367 9.81 CD36 COL2A1 GALNS GNPTAB IGF1 IGF2
10 limbs/digits/tail MP:0005371 9.8 COL2A1 COL9A1 COL9A2 IGF1 IGF2 MMP16
11 skeleton MP:0005390 9.73 CD36 COL2A1 COL9A1 COL9A2 GALNS GNPTAB
12 vision/eye MP:0005391 9.28 CD36 CLCN2 COL2A1 COL9A1 GALNS GNPTAB
Sources

Drugs & Therapeutics for Osteochondrosis

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Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 3
2
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
5 Sodium Channel Blockers Phase 1, Phase 2
6 Anti-Arrhythmia Agents Phase 1, Phase 2
7 Diuretics, Potassium Sparing Phase 1, Phase 2
8 Pharmaceutical Solutions Phase 2
9 Hormones Phase 2
10 Antineoplastic Agents, Hormonal Phase 2
11 Hormone Antagonists Phase 2
12
protease inhibitors Phase 2
13 Antiemetics Phase 2
14 HIV Protease Inhibitors Phase 2
15 Dexamethasone 21-phosphate Phase 2
16 Gastrointestinal Agents Phase 2
17 BB 1101 Phase 2
18 glucocorticoids Phase 2
19 Anti-Inflammatory Agents Phase 2
20
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
21 Anesthetics
22 Anesthetics, Local
23 Vitamins
24 Calciferol
25 Astragalus
26 Fibrin Tissue Adhesive
27 Calcium, Dietary
28
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
2 Treatment of the Osgood Schlatter Disease by Immobilization ( Ankle Cruro Resin ) Versus Sporting Rest ( Reference Treatment ) : Randomized Controlled Study Unknown status NCT02824172 Phase 3
3 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
4 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
5 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
6 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
7 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation（CS-ACI）for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
8 Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents. Completed NCT01300754 Phase 1, Phase 2
9 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
10 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
11 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
12 Repair of Articular Osteochondral Defect Unknown status NCT01409447
13 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Unknown status NCT01405664
14 Mesenchymal Stem Cell Transplantation in the Treatment of Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
15 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
16 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
17 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
18 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
19 "One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions Unknown status NCT02005861
20 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
21 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
22 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis in Adolescent Girls Completed NCT03851367
23 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
24 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Completed NCT01471236
25 A Prospective Investigation of Osgood Schlatter With 24 Month Follow-up Completed NCT03589001
26 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394
27 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
28 Verification and Progress of Cytokine Profiles and suPAR for the Discrimination of Infectious and Non-infectious, Degenerative Diseases of the Spine Completed NCT02554227
29 Agili-Câ„¢ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Completed NCT02423629
30 Effects of Low Frequency Neuromuscular Electrical Stimulation Applied to the Quadriceps in the Production of Knee Extension Strength and Control of Edema After Anterior Cruciate Ligament Reconstruction Completed NCT01633047
31 Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing Completed NCT00284661
32 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Recruiting NCT02397278 Platelet rich plasma (PRP)
33 Evaluation of Polymorphisms in the Vitamin D Receptor and Involved in Inflammation Associated With Vertebral Osteochondrosis Recruiting NCT04195529
34 Prospective 2-year Data Collection of the First 10 Patients After Ankle Spacer Recruiting NCT04297449
35 Introduction of Autologous Chondrocyte Implantation Procedure for the Treatment of Chondral Defect in the Knee Recruiting NCT04296487
36 Collecting Diagnostic, Treatment and Follow-up Data on Knee Treatments. Recruiting NCT04364334
37 The Effects of Custom-made Insoles on Foot Pressure Redistribution and Spatio - Temporal Gait Parameters in Sever Disease Recruiting NCT03787316
38 Study Protocol for a Prospective Observational Study to Evaluate the Clinical and Imaging Results of the Fresh Osteochondral Allograft Transplantation for Osteochondral Knee Lesions Recruiting NCT04236492
39 A Pilot Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects of the Talus Recruiting NCT03696394
40 Multicentric Observational Study on the Use of a Human Bone Graft in Osteochondral Defects Recruiting NCT03777735
41 A Prospective Trial on the Clinical Efficacy of the Ankle Spacer for the Surgical Treatment of Large, Multiple, Cystic and Secondary or Tertiary Osteochondral Defects of the Talus Recruiting NCT03303690
42 Biological Effects of a Bipolar Radiofrequency-based Device Over Shoulder Cartilage - a Randomized Controlled Clinical Trial Recruiting NCT04309344
43 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Recruiting NCT03625180
44 Focal Cartilage Defects in the Knee -A Randomized Controlled Trial Comparing Autologous Chondrocyte Implantation With Arthroscopic Debridement Recruiting NCT02636881
45 Detection by Digital PCR and Next Generation Sequencing of Recurrent Mutations in Waldenström's Disease and Study of Their Distribution in the Different Biological Compartments Recruiting NCT03952052
46 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Active, not recruiting NCT01754298
47 Retrospective Chart Analysis of Elbow Arthroscopy for the Treatment of Osteoarthritis, Radiocapitellar Plica, Lateral Epicondylitis or Osteochondritis Dissecans Active, not recruiting NCT03656185
48 ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee Active, not recruiting NCT02771496
49 Post Market, Longitudinal Data Collection Study of DeNovo NT for Articular Cartilage Defects of the Knee Active, not recruiting NCT01329445
50 A Randomized Trial Comparing Autologous Chondrocyte Implantation Using Collagen Membrane (ACI-C) Versus (Autologous Matrix Induced Chondrogenesis) AMIC for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel, autologous cultured chondrocytes for treatment of cartilage defects
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel) PMIDs: 17515233 17590152 16510814
Sources

Genetic Tests for Osteochondrosis

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Sources

Anatomical Context for Osteochondrosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

19
Bone

MalaCards organs/tissues related to Osteochondrosis:

40
Bone, Bone Marrow, Heart, Spinal Cord, Brain, Skin, Pituitary
Sources

Publications for Osteochondrosis

About this section

Articles related to Osteochondrosis:

(show top 50) (show all 4400)
# Title Authors PMID Year
1
Aggrecanopathies highlight the need for genetic evaluation of ISS children. 61
32413843 2020
2
Osteochondritis Dissecans of the Knee: Short-Term Outcomes of a Hybrid Technique to Restore a Partially Salvageable Progeny Fragment. 61
30141694 2020
3
Osteochondritis Dissecans in the Knee of Skeletally Immature Patients: Rates of Persistent Pain, Osteoarthritis, and Arthroplasty at Mean 14-Years' Follow-Up. 61
29998745 2020
4
Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review. 61
29998741 2020
5
Advances in Sports Medicine and Care of the Adolescent Athlete. 61
32389257 2020
6
MRI findings of intermediate cuneiform osteochondrosis as a rare cause of foot pain in a child. 61
32322328 2020
7
Genetics of Equine Orthopedic Disease. 61
32534855 2020
8
Fresh Precut Osteochondral Allograft Core Transplantation for the Treatment of Capitellum Osteochondritis Dissecans. 61
32577354 2020
9
Capitellar Osteochondritis Dissecans Lesions of the Elbow: A Systematic Review of Osteochondral Graft Reconstruction Options. 61
32035172 2020
10
Editorial Commentary: Should We Consider Early Retirement for Adolescent Pitchers and Catchers With Osteochonditis Dissecans of the Capitellum? 61
32370890 2020
11
Long-Term Outcomes of Arthroscopic Debridement With or Without Drilling for Osteochondritis Dissecans of the Capitellum in Adolescent Baseball Players: A ≥10-Year Follow-Up Study. 61
32001276 2020
12
Biomechanical Changes of Repair Tissue after Autologous Chondrocyte Implantation at Long-Term Follow-Up. 61
32447977 2020
13
[The social hygienic characteristic of patients with osteochondrosis of spine]. 61
32526116 2020
14
Description of a rare osteochondrosis lesion of the medial aspect of the distal intermediate ridge of the tibia in seven Thoroughbred horses (2008-2018). 61
32020748 2020
15
Van Neck-Odelberg disease in a 8-year-old children: a rare case report. 61
32555103 2020
16
Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. 61
31797146 2020
17
A Staged Arthroscopic Approach to Fixation of Unstable Osteochondritis Dissecans in the Medial Femoral Condyle of the Knee Using Nonabsorbable Fixation Screws. 61
32368467 2020
18
Management of the Failed OCD. 61
32147780 2020
19
MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T. 61
32278071 2020
20
Alleged predisposing dietary factors fail to increase the incidence of osteochondrosis-like lesions in growing pigs at 14 and 24 wk of age. 61
32249288 2020
21
Proteoglycan-4 and hyaluronan composition in synovial fluid and serum from clinical equine subjects: relationship to cartilage boundary lubrication and viscosity of synovial fluid. 61
32306780 2020
22
Autologous Chondrocyte Implantation as Treatment for Unsalvageable Osteochondritis Dissecans: 10- to 25-Year Follow-up. 61
32181674 2020
23
All-Arthroscopic Osteochondral Autograft Transfer Technique for Osteochondritis Dissecans of the Talus. 61
32368470 2020
24
Technique for Arthroscopic Debridement and Microfracture of Unstable, Contained Osteochondritis Dissecans Lesions of the Capitellum. 61
32368475 2020
25
The Influence of Physeal Status on Rate of Reoperation After Arthroscopic Screw Fixation for Symptomatic Osteochondritis Dissecans of the Knee. 61
31870748 2020
26
Erratum to "Closed-Wedge Osteotomy of the Distal Humerus for Treating Osteochondritis Dissecans of the Capitellum in Young Patients". 61
32284942 2020
27
A case report of osteochondritis dissecans of the first metatarsophalangeal joint treated with autologous cancellous bone and chondral flap reconstruction. 61
32153761 2020
28
Juvenile Osteochondritis Dissecans of the Trochlea: A Cohort Study of 34 Trochlear Lesions Associated With Sporting Activities That Load the Patellofemoral Joint. 61
32028470 2020
29
Early Radiographic Healing and Functional Results After Autologous Osteochondral Grafting for Osteochondritis Dissecans of the Capitellum: Introduction of a New Magnetic Resonance Imaging-Based Scoring System. 61
32053395 2020
30
Measuring Knee Bone Marrow Perfusion Using Arterial Spin Labeling at 3 T. 61
32210271 2020
31
Open Reduction and Internal Fixation for the Treatment of Symptomatic Osteochondritis Dissecans of the Femoral Head in Patients With Sequelae of Legg-Calvé-Perthes Disease. 61
32028473 2020
32
Osteochondritis Dissecans in Pediatric Patients with Juvenile Idiopathic Arthritis. 61
31941802 2020
33
Development of the blood supply to the growth cartilage of the medial femoral condyle of foals. 61
32144821 2020
34
Osteochondritis Dissecans Lesion Location Is Highly Concordant With Mechanical Axis Deviation. 61
32167842 2020
35
Editorial Commentary: Osteochondritis Dissecans of the Knee: The Great Confounder. 61
32139056 2020
36
Failure of Surgery for Osteochondral Injuries of the Elbow in the Pediatric and Adolescent Population. 61
31950429 2020
37
Long-term Results of Matrix-assisted Autologous Chondrocyte Transplantation Combined With Autologous Bone Grafting for the Treatment of Juvenile Osteochondritis Dissecans. 61
31107345 2020
38
[Not a Chronic Tennis Elbow]. 61
32019453 2020
39
Cervical articular process joint osteochondrosis in Warmblood foals. 61
32009243 2020
40
Osteochondritis dissecans of the glenoid in gymnasts: Report of two cases. 61
32107134 2020
41
Early Results of Single-plug Autologous Osteochondral Grafting for Osteochondritis Dissecans of the Capitellum in Adolescents. 61
31923167 2020
42
Contralateral Lateral Femoral Condyle Allografts Provide an Acceptable Surface Match for Simulated Classic Osteochondritis Dissecans Lesions of the Medial Femoral Condyle. 61
32064295 2020
43
Osteochondral Reconstruction of the Capitellum. 61
31739884 2020
44
Synovial sepsis of unknown origin in the adult Thoroughbred racehorse. 61
31006125 2020
45
A triplanar osteotomy technique in arthroscopy-assisted ankle mosaicplasty. 61
32189573 2020
46
A novel autologous-made matrix using hyaline cartilage chips and platelet-rich growth factors for the treatment of full-thickness cartilage or osteochondral defects: Preliminary results. 61
31835970 2020
47
Matrix induced autologous chondrocyte implantation in the knee: Comparison between osteochondritis dissecans and osteonecrosis and effect of chondrocyte thickness on prognosis. 61
32175899 2020
48
Use of nuclear medicine methods in surgical treatment of lumbar spine degeneration. 61
32122139 2020
49
Nonoperative treatment of stable juvenile osteochondritis dissecans of the knee: effectiveness of unloader bracing. 61
31774736 2020
50
Tissue-derived decellularized extracellular matrices toward cartilage repair and regeneration. 61
32334715 2020
Sources

Variations for Osteochondrosis

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Sources

Expression for Osteochondrosis

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Search GEO for disease gene expression data for Osteochondrosis.
Sources

Pathways for Osteochondrosis

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Pathways related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.68 TGFB1 OSM IGF2 IGF1 COL9A3 COL9A2
2
Integrin Pathway 63
Show member pathways
 13.28 TGFB1 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
3
Phospholipase-C Pathway 63
Show member pathways
 12.87 TGFB1 IGF2 IGF1 COL9A3 COL9A2 COL9A1
4
PI3K-Akt signaling pathway 36
Show member pathways
 12.81 OSM IGF2 IGF1 COL9A3 COL9A2 COL9A1
5
Focal Adhesion 36 1
Show member pathways
 12.74 IGF1 COL9A3 COL9A2 COL9A1 COL2A1
6
Collagen chain trimerization 65
Show member pathways
 12.68 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
7
Degradation of the extracellular matrix 65
Show member pathways
 12.41 TGFB1 MMP16 COL9A3 COL9A2 COL9A1 COL2A1
8
ECM-receptor interaction 36
Show member pathways
 11.96 COL9A3 COL9A2 COL9A1 COL2A1 CD36
9
Adipogenesis 1
11.9 TGFB1 OSM NR3C1 IGF1
10
Interleukin-4 and 13 signaling 65
11.82 TGFB1 OSM CD36
11
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.74 TGFB1 IGF1 COL2A1 ACAN
12
Cell adhesion_ECM remodeling 22
11.49 MMP16 IGF2 IGF1 COL2A1
13
Endochondral Ossification 1
11.47 TGFB1 IGF2 IGF1 COL2A1 ACAN
14
Cardiac Progenitor Differentiation 1
11.45 TGFB1 IGF2 IGF1
15
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.35 VDR NR3C1 IGF1
16
NCAM1 interactions 65
11.24 COL9A3 COL9A2 COL9A1
17
ECM proteoglycans 65
11.11 TGFB1 COL9A3 COL9A2 COL9A1 ACAN
18
RXR and RAR heterodimerization with other nuclear receptor 1
10.71 VDR TGFB1
19
G-protein signaling_Rap2B regulation pathway 22
10.23 TGFB1 OSM IGF2 IGF1 COL9A3 COL9A2
Sources

GO Terms for Osteochondrosis

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Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.15 TGFB1 OSM MMP16 IGF2 IGF1 GALNS
2 extracellular space GO:0005615 10.06 TGFB1 OSM MMP16 IGF2 IGF1 COL9A3
3 endoplasmic reticulum lumen GO:0005788 9.8 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
4 collagen-containing extracellular matrix GO:0062023 9.8 TGFB1 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
5 Golgi lumen GO:0005796 9.63 TGFB1 MMP16 ACAN
6 platelet alpha granule lumen GO:0031093 9.61 TGFB1 IGF2 IGF1
7 collagen trimer GO:0005581 9.43 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1 CD36
8 collagen type IX trimer GO:0005594 9.33 COL9A3 COL9A2 COL9A1
9 extracellular matrix GO:0031012 9.23 TGFB1 MMP16 COL9A3 COL9A2 COL9A1 COL2A1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.81 VDR TGFB1 IGF1 CD36
2 ossification GO:0001503 9.67 MMP16 IGF2 COL2A1
3 platelet degranulation GO:0002576 9.62 TGFB1 IGF2 IGF1 CD36
4 positive regulation of MAPK cascade GO:0043410 9.56 OSM IGF2 IGF1 CD36
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.55 TGFB1 OSM IGF2 IGF1 CD36
6 positive regulation of cell division GO:0051781 9.54 TGFB1 OSM IGF2
7 positive regulation of glycogen biosynthetic process GO:0045725 9.52 IGF2 IGF1
8 extracellular matrix organization GO:0030198 9.5 MMP16 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
9 positive regulation of transcription regulatory region DNA binding GO:2000679 9.48 TGFB1 IGF1
10 intestinal absorption GO:0050892 9.46 VDR CD36
11 cell activation GO:0001775 9.43 TGFB1 IGF1
12 keratan sulfate catabolic process GO:0042340 9.4 GALNS ACAN
13 skeletal system development GO:0001501 9.17 VDR MMP16 IGF2 IGF1 COL9A2 COL2A1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 TGFB1 OSM IGF2 IGF1
2 extracellular matrix structural constituent GO:0005201 9.43 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1 ACAN
3 insulin-like growth factor receptor binding GO:0005159 9.26 IGF2 IGF1
4 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.02 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
Sources

Sources for Osteochondrosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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