MCID: OST016
MIFTS: 52

Osteochondrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Osteochondrosis

MalaCards integrated aliases for Osteochondrosis:

Name: Osteochondrosis 12 20 58 15 37 70
Osteochondritis 12 73 70
Osteochondritis Juvenilis 12 70
Apophysitis 12 70
Epiphysitis 12 70
Juvenile Osteochondrosis of Tibial Tubercle 70
Epiphyseal Necrosis 12

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:8125
ICD9CM 34 732.6
MeSH 44 D055034
NCIt 50 C34879
SNOMED-CT 67 203398006 65477003
ICD10 32 M92 M93.9
ICD10 via Orphanet 33 M93.9
UMLS via Orphanet 71 C0029429
Orphanet 58 ORPHA399319
UMLS 70 C0014574 C0029376 C0029420 more

Summaries for Osteochondrosis

Disease Ontology : 12 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis, is related to scheuermann disease and legg-calve-perthes disease. An important gene associated with Osteochondrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Anastrozole and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are cellular and immune system

Wikipedia : 73 Osteochondritis is a painful type of osteochondrosis where the cartilage or bone in a joint is... more...

Related Diseases for Osteochondrosis

Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 scheuermann disease 32.7 GNPTAB COL9A3 COL2A1
2 legg-calve-perthes disease 31.9 MATN3 GNPTAB GALNS COL2A1
3 epiphyseal dysplasia, multiple, 2 31.0 MATN3 COL9A3 COL9A2 COL9A1
4 arthropathy 30.6 IGF1 COL2A1 ACAN
5 osteochondritis dissecans 30.3 MATN3 COL9A3 COL9A2 COL9A1 CD36 ACAN
6 back pain 30.2 COL9A3 COL9A2
7 osteoarthritis 30.1 TGFB1 MATN3 COL9A1 COL2A1 ACAN
8 scoliosis 30.0 VDR TGFB1 IGF1 COL2A1 ACAN
9 brittle bone disorder 30.0 IGF1 COL2A1 CD36 ACAN
10 patella, chondromalacia of 29.7 COL2A1 ACAN
11 otosclerosis 29.7 VDR TGFB1 MATN3 CD36
12 spinal stenosis 29.6 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
13 osteoporosis 29.5 VDR TGFB1 NR3C1 IGF2 IGF1 COL2A1
14 bone disease 29.5 VDR MATN3 IGF1 COL2A1 CD36 ACAN
15 multiple epiphyseal dysplasia 29.4 MATN3 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
16 stickler syndrome 29.1 MATN3 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
17 spondyloepiphyseal dysplasia with congenital joint dislocations 29.0 GALNS COL9A3 COL9A2 COL9A1 COL2A1 ACAN
18 familial osteochondritis dissecans 11.7
19 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.6
20 kohler's disease 11.4
21 blount's disease 11.3
22 osgood-schlatter's disease 11.3
23 panner disease 11.2
24 freiberg's disease 11.1
25 sinding-larsen-johansson disease 11.0
26 achilles bursitis 11.0
27 kienbock's disease 10.9
28 blount disease, infantile 10.9
29 thiemann disease 10.9
30 blount disease, adolescent 10.9
31 osteochondrosis of genetic origin 10.9
32 osteochondrosis of the metatarsal bone 10.9
33 ruvalcaba syndrome 10.9
34 bazex syndrome 10.9
35 loeys-dietz syndrome 3 10.9
36 early congenital syphilis 10.9
37 idiopathic avascular necrosis 10.6
38 keloid disorder 10.3 TGFB1 CD36
39 potter's syndrome 10.3 IGF2 IGF1
40 achondroplasia 10.3 IGF1 COL2A1 ACAN
41 inflammatory spondylopathy 10.3
42 spondylosis 10.3
43 spondylitis 10.3
44 fibromatosis, gingival, 1 10.3 TGFB1 CD36
45 stickler syndrome, type i 10.3 COL9A2 COL2A1
46 odontogenic myxoma 10.3 CD36 ACAN
47 fasting hypoglycemia 10.2 IGF2 IGF1 CD36
48 ischemic bone disease 10.2 IGF1 COL2A1 ACAN
49 parathyroid adenoma 10.2 VDR TGFB1 IGF1
50 periarthritis 10.2

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

MGI Mouse Phenotypes related to Osteochondrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 CD36 COL2A1 COL9A1 GALNS GNPTAB IGF1
2 immune system MP:0005387 10 CD36 COL2A1 COL9A1 COL9A3 GNPTAB IGF1
3 digestive/alimentary MP:0005381 9.97 CD36 COL2A1 GNPTAB IGF2 MMP16 NR3C1
4 limbs/digits/tail MP:0005371 9.81 COL2A1 COL9A1 COL9A2 GNPTAB IGF1 IGF2
5 hearing/vestibular/ear MP:0005377 9.8 COL2A1 COL9A1 COL9A2 COL9A3 IGF1 VDR
6 renal/urinary system MP:0005367 9.61 CD36 COL2A1 GALNS GNPTAB IGF1 IGF2
7 skeleton MP:0005390 9.47 CD36 COL24A1 COL2A1 COL9A1 COL9A2 GALNS

Drugs & Therapeutics for Osteochondrosis

Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 2, Phase 3 120511-73-1 2187
2 Anesthetics Phase 2, Phase 3
3 Fibrin Tissue Adhesive Phase 3
4 Mitogens Phase 3
5 Hormone Antagonists Phase 2, Phase 3
6 Hormones Phase 2, Phase 3
7 Antineoplastic Agents, Hormonal Phase 2, Phase 3
8 Estrogens Phase 2, Phase 3
9 Estrogen Receptor Antagonists Phase 2, Phase 3
10 Estrogen Antagonists Phase 2, Phase 3
11 Aromatase Inhibitors Phase 2, Phase 3
12
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
14
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
15 Anti-Arrhythmia Agents Phase 1, Phase 2
16 Sodium Channel Blockers Phase 1, Phase 2
17 Diuretics, Potassium Sparing Phase 1, Phase 2
18 Gastrointestinal Agents Phase 2
19 Pharmaceutical Solutions Phase 2
20 Dexamethasone 21-phosphate Phase 2
21 glucocorticoids Phase 2
22 Antiemetics Phase 2
23 Anti-Inflammatory Agents Phase 2
24
protease inhibitors Phase 2
25 BB 1101 Phase 2
26 HIV Protease Inhibitors Phase 2
27
Acetaminophen Approved 103-90-2 1983
28
Becaplermin Approved, Investigational 165101-51-9
29
Epinephrine Approved, Vet_approved 51-43-4 5816
30
Racepinephrine Approved 329-65-7 838
31
Morphine Approved, Investigational 57-27-2 5288826
32
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
33 Vitamins
34 Calciferol
35 Astragalus
36 Calcium, Dietary
37 Epinephryl borate
38 Calamus
39 Anesthetics, Local
40
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 120)
# Name Status NCT ID Phase Drugs
1 Long Term Study Of Pnu-180307 For Short Children Born Small For Gestational Age (Sga) Without Epiphyseal Closure (Extension Of The Study 307-met-0021-002) Completed NCT01859949 Phase 4 Genotropin (somatropin)
2 Multicenter Randomized Controlled Trial for the Treatment of Knee Chondral and Osteochondral Lesions: Marrow Stimulation Techniques vs MaioRegen Completed NCT01282034 Phase 4
3 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
4 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
5 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
6 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
7 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
8 Double-blind Trial Investigating the Safety and Efficacy of the Inhibitor Anastrozole (ARIMIDEX) in Delaying Epiphyseal Fusion and Increasing Height Potential of Adolescent Males With Growth Hormone (GH) Deficiency Completed NCT00133354 Phase 2, Phase 3 Arimidex (Anastrozole);Placebo;Growth Hormone
9 Evaluation of the Composite of Cancellous and Demineralized Bone Plug (CR Plug) for Repair of Defects Created at the Harvest Site During the Osteochondral Autograft Transfer System(OATS)Procedure Completed NCT00821873 Phase 3
10 Randomized, Multicentric, Prospective, Double-blind Study: Effectiveness of Adding Allogenic Stem Cells to a Platelet-poor Plasma Scaffold After Arthroscopic Debridement and Microfractures in Patients With Osteochondral Lesions of the Talus Recruiting NCT03905824 Phase 3
11 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
12 A Multi-center, Single-blind, Randomized, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Adding CARTISTEM® on Microfracture in Patients With Talar Chondral or Osteochondral Defect Enrolling by invitation NCT04310215 Phase 3
13 Evaluation of the Composite of Cancellous and Demineralized Bone Plug (CR-Plug) for Repair of Osteochondral Defects in High-Load-Bearing Region and Low-Load-Bearing Region of the Femoral Condyle Terminated NCT00984594 Phase 3
14 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
15 Treatment of Osteochondral Lesion of Talus With Processed Osteochondral Allograft Unknown status NCT02736318 Phase 1, Phase 2
16 Second Line Treatment of Knee Osteochondral Lesion With Decellularized Treated Osteochondral Allograft. Phase IIa Trial Unknown status NCT02430558 Phase 1, Phase 2
17 Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents. Completed NCT01300754 Phase 1, Phase 2
18 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
19 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
20 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
21 An Observational, Prospective, Multicentre Study of Patients With Outerbridge Grade III / IV Chondral and/or Osteochondral Defects of the Knee Treated With Nanofractured Autologous Matrix-induced Chondrogenesis Unknown status NCT03625180
22 Fascial Distortion Model Manual Therapy and Painful Shoulder Syndrome Unknown status NCT03521778
23 Repair of Articular Osteochondral Defect Unknown status NCT01409447
24 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
25 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
26 Comparison of the Outcomes of the Treatment of Semiepiphysiodesis Using Hinged and Conventional 8-figure Plates: A Randomized Controlled Clinical Trial Unknown status NCT03378206
27 Comparison Between the Subglotic Diameter and the Epiphyseal Diameter of the Radius in Children for Prediction of Appropriate Endotracheal Tube Sizes Unknown status NCT03713385
28 Therapeutic Effects and Safety of Percutaneous Disc Decompression With Coblation Nucleoplasty in Cervical Vertigo Unknown status NCT03485768
29 Mesenchymal Stem Cell Transplantation in the Treatment of Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
30 "One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions Unknown status NCT02005861
31 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
32 Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results Unknown status NCT03908931
33 Extracorporeal Shock Wave Therapy for Pain-Relief After Arthroscopy for Osteochondral Lesions of the Talus Unknown status NCT03750253
34 Clinical Trial of the Safety and Efficacy of Allogenic Umbilical Cord Blood-derived Mesenchymal Stem Cell Product With Microfracture for Osteochondral Lesion of Talus Patients Unknown status NCT02338375 Early Phase 1
35 Comparing Outcomes of Microfracture Versus Microfracture and Bone Marrow Aspirate Concentrate for the Treatment of Osteochondral Lesions of the Talus Unknown status NCT03856021
36 Clinical and Radiological Results of Osteochondral Repair Using MaioRegen in Knee and Ankle Surgery Unknown status NCT02345564
37 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Completed NCT01754298
38 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Completed NCT02397278 Platelet rich plasma (PRP)
39 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
40 Follow-Up Study Evaluating the Long-Term Outcomes of ChondroMimetic in the Treatment of Osteochondral Defects (Extension Study of Protocol 0MCM0107) Completed NCT03385642
41 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects (OCD) Completed NCT02423629
42 Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis in Adolescent Girls Completed NCT03851367
43 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Completed NCT01471236
44 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
45 The Effects of Custom-made Insoles on Foot Pressure Redistribution and Spatio - Temporal Gait Parameters in Sever Disease Completed NCT03787316
46 Yulin Orthopedics Hospital of Chinese and Western Medicine Completed NCT03129230
47 AN INVESTIGATION INTENDED TO EVALUATE THE LONG-TERM EFFICACY AND SAFETY OF GENOTROPIN IN CHILDREN WITH SGA DWARFISM WITHOUT EPIPHYSEAL CLOSURE. (RETROSPECTIVE STUDY) Completed NCT01897766 Somatropin
48 Comparative Effects of Sustained Natural Apophyseal Glides and Mechanical Cervical Traction in the Management of Cervical Radiculopathy Completed NCT03362567
49 Volar Plates for Distal Radius : Can Epiphyseal Screw Length be Predicted Completed NCT03634865
50 A Multicentre, Open Label, Observational, Non-interventional Study to Evaluate on Long-term Safety and Efficacy of Norditropin® Formulation in Patients With SGA Short Stature Without Closure of Epiphyseal Discs Completed NCT01110928 somatropin

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel, autologous cultured chondrocytes for treatment of cartilage defects
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel) PMIDs: 17515233 17590152 16510814

Genetic Tests for Osteochondrosis

Anatomical Context for Osteochondrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

19
Bone

MalaCards organs/tissues related to Osteochondrosis:

40
Bone, Bone Marrow, Spinal Cord, Skin, Pituitary, Eye, Retina

Publications for Osteochondrosis

Articles related to Osteochondrosis:

(show top 50) (show all 4515)
# Title Authors PMID Year
1
Tennis overuse injuries in the upper extremity. 61
33009583 2021
2
Influence of osteochondrosis on the longevity and racing performance of standardbred trotters and pacers. 61
33460472 2021
3
Validity of Ultrasound Compared with Magnetic Resonance Imaging in Evaluation of Osteochondritis Dissecans of the Distal Femur in Children. 61
30704293 2021
4
Comparison Between Osteochondral Autograft Transplantation and Arthroscopic Fragment Resection for Large Capitellar Osteochondritis Dissecans in Adolescent Athletes: A Minimum 5 Years' Follow-up. 61
33705216 2021
5
Safety and performance of biodegradable magnesium-based implants in children and adolescents. 61
33775413 2021
6
Limiting the Pitch Count in Youth Baseball Pitchers Decreases Elbow Pain. 61
33796588 2021
7
Overuse Elbow Injuries in Youth Gymnasts. 61
33780632 2021
8
Towards a definition of Ancient Rare Diseases (ARD): Presenting a complex case of probable Legg-Calvé-Perthes Disease from the North Caucasian Bronze Age (2200-1650 cal BCE). 61
33360164 2021
9
A Modification of the Cheli Craniolateral Approach for Minimally Invasive Treatment of Osteochondritis Dissecans of the Shoulder in Dogs: Description of the Technique and Outcome in 164 Cases. 61
33232983 2021
10
Prevalence of hypovitaminosis D in patients with juvenile osteochondritis dissecans. 61
33281101 2021
11
Magnetic Resonance Imaging in Osteochondritis Dissecans of the Humeral Capitellum: Preoperative Assessment of Lesion Size and Lateral Wall Integrity. 61
33795154 2021
12
Novel Magnetic Resonance Imaging Classification of Osteochondritis Dissecans of the Knee: A Reliability Study. 61
33782366 2021
13
The Shoulder Joint and Common Abnormalities. 61
33446362 2021
14
Canine Elbow Dysplasia: Ununited Anconeal Process, Osteochondritis Dissecans, and Medial Coronoid Process Disease. 61
33558015 2021
15
Internal Fixation of Osteochondritis Dissecans Using PushLock Suture Anchors. 61
33738205 2021
16
The Use of Elbow Arthroscopy for Management of the Pediatric Elbow: A Systematic Review of Indications and Outcomes. 61
33539972 2021
17
Prevalence and Severity of Juvenile Osteochondritis Dissecans in Patients With Juvenile Idiopathic Arthritis. 61
33718500 2021
18
Radiological, vascular osteochondrosis occurs in the distal tarsus, and may cause osteoarthritis. 61
33534938 2021
19
Osteochondrosis of Ischiopubic Synchondrosis: Van Neck-Odelberg Disease. 61
32941843 2021
20
Electromagnetic navigation reduces radiation exposure for retrograde drilling in osteochondrosis dissecans of the talus. 61
33536008 2021
21
Treatment of advanced stage osteochondrosis dissecans in the adolescent elbow using a hyaloronic acid-based scaffold: a case series of 5 patients. 61
33543384 2021
22
Osteochondral autograft transplantation versus autologous bone-cartilage paste grafting for the treatment of knee osteochondritis dissecans. 61
32959150 2021
23
The nonoperative treatment of osteochondritis dissecans of the knee. 61
33315689 2021
24
Ankle Morphology and Juvenile Osteochondritis Dissecans (JOCD) of the Talus: Is There an Association? An MRI Study. 61
33229961 2021
25
Degenerative spine disease: Italian position paper on acquisition, interpretation and reporting of Magnetic Resonance Imaging. 61
33575851 2021
26
A high rate of children and adolescents return to sport after surgical treatment of osteochondritis dissecans of the elbow: a systematic review and meta-analysis. 61
33620512 2021
27
Predictors of Failure of Return to Play in Youth Baseball Players After Capitellar Osteochondritis Dissecans: Focus on Elbow Valgus Laxity and Radiocapitellar Congruity. 61
33321050 2021
28
Editorial Commentary: Early Operative Management of "Stable" Osteochondritis Dissecans Lesions Confers Greater Value in Skeletally Immature Patients. 61
33546800 2021
29
Cost-Effectiveness Analysis of Nonoperative Management Versus Early Drilling for Stable Osteochondritis Dissecans Lesions of the Knee in Skeletally Immature Patients. 61
33271176 2021
30
Surgical Fixation of Chondral-Only Fragments of the Knee: A Case Series With a Mean 4-Year Follow-up. 61
33521156 2021
31
Radiographic diagnosis and surgical management for successful outcomes for osteochondrosis in Japanese Black calves. 61
33390374 2021
32
Distinguishing between congenital phenomena and traumatic experiences: Osteochondrosis versus osteochondritis. 61
33551611 2021
33
The dimensions of "failed back surgery syndrome": what is behind a label? 61
32875358 2021
34
Rheumatic immune-related adverse events associated with immune checkpoint inhibitors compared with placebo in oncologic patients: a systemic review and meta-analysis. 61
33633822 2021
35
Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans. 61
33423507 2021
36
Development of the blood supply to the growth cartilage of the medial femoral condyle of foals. 61
32144821 2021
37
Progression of Epiphyseal Cartilage and Bone Pathology in Surgically Treated Cases of Osteochondritis Dissecans of the Elbow. 61
33196301 2021
38
Management of bilateral osteochondritis dissecans of the trochlea in a skeletally immature patient. 61
33504536 2021
39
Multiple Osteochondritis Dissecans in Multiple Joints. 61
33575051 2021
40
Predictive factors for developing osteochondritis dissecans after surgery for discoid lateral meniscus are younger age and shorter meniscal width. 61
31642945 2021
41
Performance of PROMIS Scores Compared to Legacy Metrics in Evaluating Outcomes after Surgical Treatment for Osteochondritis Dissecans of the Humeral Capitellum. 61
33486062 2021
42
Lateral wall fixation with bone pegs for advanced osteochondritis dissecans of the humeral capitellum. 61
33554161 2021
43
A novel three-dimensional MRI-CT image fusion technique for precise preoperative evaluation and treatment of capitellar osteochondritis dissecans. 61
33454801 2021
44
Evaluation and Surgical Management of Knee Osteochondritis Dissecans and Adolescent Cartilage Injuries. 61
33438925 2021
45
What's New in Osteochondritis Dissecans of the Knee, Elbow, and Ankle. 61
33438926 2021
46
A novel mutation in the ACAN gene in a family with autosomal dominant short stature and intervertebral disc disease. 61
33298914 2020
47
Dual diagnosis of osteogenesis imperfecta (OI) and short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD) reveals a cumulative effect on stature caused by mutations in COL1A1 and ACAN genes. 61
32980524 2020
48
Lameness in fattening pigs - Mycoplasma hyosynoviae, osteochondropathy and reduced dietary phosphorus level as three influencing factors: a case report. 61
33323132 2020
49
Osteochondral Autograft Transfer for Capitellar Chondral and Osteochondral Defects. 61
33294333 2020
50
Risk factors for hospital admission in patients undergoing outpatient anterior cruciate ligament reconstruction: A national database study. 61
33071518 2020

Variations for Osteochondrosis

Expression for Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for Osteochondrosis

Pathways related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 TGFB1 OSM IGF2 IGF1 COL9A3 COL9A2
2
Show member pathways
13.28 TGFB1 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
3
Show member pathways
12.87 TGFB1 IGF2 IGF1 COL9A3 COL9A2 COL9A1
4
Show member pathways
12.81 OSM IGF2 IGF1 COL9A3 COL9A2 COL9A1
5
Show member pathways
12.74 IGF1 COL9A3 COL9A2 COL9A1 COL2A1
6
Show member pathways
12.69 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
7
Show member pathways
12.46 TGFB1 MMP16 MATN3 COL9A3 COL9A2 COL9A1
8
Show member pathways
11.96 COL9A3 COL9A2 COL9A1 COL2A1 CD36
9 11.9 TGFB1 OSM NR3C1 IGF1
10 11.85 TGFB1 COL2A1 ACAN
11 11.82 TGFB1 OSM CD36
12 11.74 TGFB1 IGF1 COL2A1 ACAN
13 11.49 MMP16 IGF2 IGF1 COL2A1
14 11.47 TGFB1 IGF2 IGF1 COL2A1 ACAN
15 11.45 TGFB1 IGF2 IGF1
16 11.35 VDR NR3C1 IGF1
17 11.25 COL9A3 COL9A2 COL9A1
18 11.19 TGFB1 MATN3 COL9A3 COL9A2 COL9A1 ACAN
19 10.71 VDR TGFB1
20 10.23 TGFB1 OSM IGF2 IGF1 COL9A3 COL9A2

GO Terms for Osteochondrosis

Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.13 TGFB1 OSM MMP16 MATN3 IGF2 IGF1
2 extracellular space GO:0005615 10.1 TGFB1 OSM IGF2 IGF1 COL9A3 COL9A2
3 endoplasmic reticulum lumen GO:0005788 9.85 MATN3 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
4 collagen-containing extracellular matrix GO:0062023 9.76 TGFB1 MATN3 COL9A3 COL9A2 COL9A1 COL2A1
5 basement membrane GO:0005604 9.73 COL9A3 COL9A1 COL2A1 ACAN
6 Golgi lumen GO:0005796 9.65 TGFB1 MMP16 ACAN
7 platelet alpha granule lumen GO:0031093 9.63 TGFB1 IGF2 IGF1
8 collagen type IX trimer GO:0005594 9.43 COL9A3 COL9A2 COL9A1
9 collagen trimer GO:0005581 9.43 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1 CD36
10 extracellular matrix GO:0031012 9.28 TGFB1 MMP16 MATN3 COL9A3 COL9A2 COL9A1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.83 VDR TGFB1 IGF1 CD36
2 ossification GO:0001503 9.69 MMP16 IGF2 COL2A1
3 platelet degranulation GO:0002576 9.62 TGFB1 IGF2 IGF1 CD36
4 positive regulation of MAPK cascade GO:0043410 9.56 OSM IGF2 IGF1 CD36
5 extracellular matrix organization GO:0030198 9.56 MMP16 MATN3 COL9A3 COL9A2 COL9A1 COL2A1
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.55 TGFB1 OSM IGF2 IGF1 CD36
7 positive regulation of interleukin-17 production GO:0032740 9.54 TGFB1 OSM
8 positive regulation of cell division GO:0051781 9.54 TGFB1 OSM IGF2
9 positive regulation of glycogen biosynthetic process GO:0045725 9.49 IGF2 IGF1
10 positive regulation of transcription regulatory region DNA binding GO:2000679 9.48 TGFB1 IGF1
11 intestinal absorption GO:0050892 9.46 VDR CD36
12 keratan sulfate catabolic process GO:0042340 9.43 GALNS ACAN
13 cell activation GO:0001775 9.4 TGFB1 IGF1
14 skeletal system development GO:0001501 9.23 VDR MMP16 MATN3 IGF2 IGF1 COL9A2

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 TGFB1 OSM IGF2 IGF1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.35 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1
3 insulin-like growth factor receptor binding GO:0005159 9.26 IGF2 IGF1
4 extracellular matrix structural constituent GO:0005201 9.17 MATN3 COL9A3 COL9A2 COL9A1 COL2A1 COL24A1

Sources for Osteochondrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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