Osteochondrosis of the Metatarsal Bone disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A rare bone disease characterized by avascular necrosis of a metatarsal head, most commonly involving the second, but also the third or fourth, metatarsal. Patients may present with pain on weight-bearing, swelling, and tenderness. Radiological features include widening of the metatarsophalangeal joint space and flattening of the affected metatarsal head, at later stages metatarsal head sclerosis, cortical thickening, and intra-articular loose bodies. The condition can be bilateral in some cases and shows a significant predilection for females in the second or third decade of life.

MalaCards based summary: Osteochondrosis of the Metatarsal Bone, also known as avascular necrosis of the metatarsal bone, is related to freiberg's disease and osteonecrosis. Affiliated tissues include bone and cortex, and related phenotypes are arthritis and joint stiffness

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Related Diseases for Osteochondrosis of the Metatarsal Bone

Diseases related to Osteochondrosis of the Metatarsal Bone via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	freiberg's disease	11.1
2	osteonecrosis	10.3
3	osteochondrosis	10.2
4	avascular necrosis	10.2
5	synovitis	10.0
6	arthropathy	10.0
7	osteoarthritis	10.0
8	dieterich's disease	10.0

Graphical network of the top 20 diseases related to Osteochondrosis of the Metatarsal Bone:

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Symptoms & Phenotypes for Osteochondrosis of the Metatarsal Bone

Human phenotypes related to Osteochondrosis of the Metatarsal Bone:

⁵⁸ ³⁰ (show all 19)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	arthritis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001369
2	joint stiffness ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001387
3	arthralgia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002829
4	difficulty walking ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002355
5	pedal edema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010741
6	osteochondrosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0040188
7	chondritis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100662
8	progressive joint destruction ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005187
9	foot pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025238
10	sclerosis of foot bone ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100925
11	structural foot deformity ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010219
12	flattened metatarsal heads ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005194
13	abnormality of metatarsal epiphysis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010630
14	abnormality of the second metatarsal bone ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0040034
15	thickened cortex of bones ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100039
16	abnormality of the third metatarsal bone ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0010672
17	abnormality of the fifth metatarsal bone ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0008089
18	abnormality of the fourth metatarsal bone ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0040035
19	avascular necrosis ⁵⁸		Occasional (29-5%)

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Drugs & Therapeutics for Osteochondrosis of the Metatarsal Bone

Search Clinical Trials, NIH Clinical Center for Osteochondrosis of the Metatarsal Bone

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Genetic Tests for Osteochondrosis of the Metatarsal Bone

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Anatomical Context for Osteochondrosis of the Metatarsal Bone

Organs/tissues related to Osteochondrosis of the Metatarsal Bone:

MalaCards : Bone, Cortex

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Publications for Osteochondrosis of the Metatarsal Bone

Articles related to Osteochondrosis of the Metatarsal Bone:

(show all 41)

#	Title	Authors	PMID	Year
1	Arthroscopic Treatment of Freiberg Disease - Case Report. ⁶²	Atilano Carvalho P...Torres A	36226204	2022
2	Description of a Revision Technique for Failed Polyvinyl Alcohol Hydrogel Implant in Patient with Freiberg's Disease. ⁶²	Elamin D...Chami G	34400091	2022
3	Management of acute lesser toe pain. ⁶²	Ray J...Shah A	33406375	2021
4	Differential diagnosis portfolio of a pediatric rheumatologist: eight cases, eight stories. ⁶²	Cakan M...Ayaz NA	32656661	2021
5	Interpositional Arthroplasty With Extensor Digitorum Brevis Tendon in Freiberg Disease. ⁶²	Cevik N...Ozkan Y	32674687	2020
6	Surgical Management of Freiberg Disease by Dorsal Closing Wedge Osteotomy. ⁶²	Dhar SA...Dar TA	33403078	2020
7	Synthetic Cartilage Implant Hemiarthroplasty for Second MTP Joint Osteoarthrosis. ⁶²	Kilmartin TE...Posmyk L	32505725	2020
8	Freiberg's Infarction as the First Clinical Presentation of Sneddon Syndrome. ⁶²	Samanta D...Cobb S	33531949	2020
9	Comparison of Osteochondral Autologous Transplantation and Dorsiflexion Closing Wedge Metatarsal Osteotomy for Late-Stage Freiberg Disease in Adults. ⁶²	Kim SJ...Kim GL	32036676	2020
10	Arthroscopic Dorsal Closing-Wedge Osteotomy of Metatarsal Head for Management of Freiberg Infraction. ⁶²	Lui TH...Fan AKH	31890497	2019
11	Osteochondral Autologous Transplantation Versus Dorsal Closing Wedge Metatarsal Osteotomy for the Treatment of Freiberg Infraction in Athletes: A Randomized Controlled Study With 3-Year Follow-up. ⁶²	Georgiannos D...Bisbinas I	31298927	2019
12	Magnetic resonance imaging of subchondral insufficiency fractures of the lower limb. ⁶²	Lee S...Saifuddin A	30706108	2019
13	Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones. ⁶²	Achar S...Yamanaka J	31083875	2019
14	[Comparison between dorsiflexion osteotomy and implant arthroplasty for advanced Freiberg disease]. ⁶²	Wu S...Zhang H	31090349	2019
15	Freiberg Disease and Avascular Necrosis of the Metatarsal Heads. ⁶²	Wax A...Leland R	30685014	2019
16	Treatment of Freiberg Disease. ⁶²	Seybold JD...Zide JR	29362030	2018
17	Return to sporting activity after osteochondral autograft transplantation for Freiberg disease in young athletes. ⁶²	Ishimatsu T...Yamamoto T	28484850	2017
18	Atypical Presentation of Acute Freiberg Disease. ⁶²	Kenny L...Parvin B	28231970	2017
19	Midterm clinical results of osteochondral autograft transplantation for advanced stage Freiberg disease. ⁶²	Miyamoto W...Kawano H	26419957	2016
20	Long-term Follow-up of Dorsal Wedge Osteotomy for Pediatric Freiberg Disease. ⁶²	Pereira BS...Duarte RM	26276134	2016
21	Late Stage Freiberg Infraction in a Division I Collegiate Tennis Player. ⁶²	Faircloth J...Edwards DS	27299057	2015
22	Extra-articular dorsal closing-wedge osteotomy to treat late-stage Freiberg disease using polyblend sutures: technical tips and clinical results. ⁶²	Ikoma K...Kubo T	24867357	2014
23	Single-photon Emission Tomography/Computed Tomography Delineation of Freiberg Infraction. ⁶²	Currie GM...Hashmi R	31051944	2014
24	[Headles cannulated screw for the treatment of Freiberg disease]. ⁶²	Li CH...Wang WL	24654527	2013
25	[Freiberg disease, a rare cause of metatarsalgia]. ⁶²	de Pablo Marquez B...Lozano Soldevilla B	24055588	2013
26	Second metatarsophalangeal joint pathology and freiberg disease. ⁶²	Shane A...Thurston P	23827490	2013
27	Simultaneous development of Dieterich disease and Freiberg disease. ⁶²	Conesa X...Novell J	23363812	2013
28	Operative treatment of Freiberg disease using extra-articular dorsal closing-wedge osteotomy: technical tip and clinical outcomes in 13 patients. ⁶²	Lee HJ...Min WK	23386770	2013
29	Osteochondral autograft transplantation for advanced stage Freiberg disease in adolescent athletes: a report of 3 cases and surgical procedures. ⁶²	Tsuda E...Sato H	21868689	2011
30	Bilateral Freiberg disease. ⁶²	Kim KJ...Cho CS	21654273	2011
31	Women's musculoskeletal foot conditions exacerbated by shoe wear: an imaging perspective. ⁶²	Goud A...Weissman BN	21731927	2011
32	Osteochondrosis: common causes of pain in growing bones. ⁶²	Atanda A...O'Brien K	21302869	2011
33	[Swanson double-stem silicone implant arthroplasty in the treatment of Freiberg disease]. ⁶²	Wen JM...Wu XB	19594037	2009
34	Avascular necrosis of the 1st metatarsal head. ⁶²	Gurevich M...Katzman A	19026196	2008
35	Late-stage Freiberg disease treated by osteochondral plug transplantation: a case series. ⁶²	Miyamoto W...Ochi M	18778677	2008
36	Foot problems in the adolescent. ⁶²	Kean JR	18605397	2007
37	Treatment of Freiberg disease with intra-articular dorsal wedge osteotomy and absorbable pin fixation. ⁶²	Lee SK...Gong HS	17257537	2007
38	Arthroscopic Keller technique for Freiberg disease. ⁶²	Carro LP...Abad J	15243427	2004
39	A new surgical technique for treating bilateral Freiberg disease. ⁶²	Hayashi K...Yamagami N	12098131	2002
40	Forefoot pain involving the metatarsal region: differential diagnosis with MR imaging. ⁶²	Ashman CJ...Yu JS	11706214	2001
41	Freiberg disease complicating unrelated trauma. ⁶²	Binek R...Rubenstein H	3399446	1988

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Genes for Osteochondrosis of the Metatarsal Bone

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Variations for Osteochondrosis of the Metatarsal Bone

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Expression for Osteochondrosis of the Metatarsal Bone

Search GEO for disease gene expression data for Osteochondrosis of the Metatarsal Bone.

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Pathways for Osteochondrosis of the Metatarsal Bone

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GO Terms for Osteochondrosis of the Metatarsal Bone

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MCID: OST177 MIFTS: 21	Osteochondrosis of the Metatarsal Bone Categories: Bone diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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