Aliases & Classifications for Osteoid Osteoma

MalaCards integrated aliases for Osteoid Osteoma:

Name: Osteoid Osteoma 57 70

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal recessive vs. viral or other etiology


HPO:

31
osteoid osteoma:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM® 57 259550
MedGen 41 C0029441
UMLS 70 C0029441

Summaries for Osteoid Osteoma

MalaCards based summary : Osteoid Osteoma is related to arthritis and sarcoma, and has symptoms including pain An important gene associated with Osteoid Osteoma is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are Focal Adhesion and Pathways in cancer. The drugs Zoledronic Acid and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are osteoma and osteoid osteoma

Wikipedia : 73 An osteoid osteoma is a benign (non-cancerous) bone tumor that arises from osteoblasts and some... more...

More information from OMIM: 259550

Related Diseases for Osteoid Osteoma

Diseases related to Osteoid Osteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.0 PTGS2 FOS
2 sarcoma 29.8 PTGS2 FOS
3 osteoblastoma 11.0
4 scoliosis 10.9
5 plica syndrome 10.9
6 synovitis 10.9
7 osteomyelitis 10.8
8 back pain 10.6
9 osteogenic sarcoma 10.5
10 tenosynovitis 10.5
11 chondroblastoma 10.4
12 torticollis 10.4
13 fibrous dysplasia 10.4
14 osteochondrosis 10.4
15 chronic pain 10.4
16 overgrowth syndrome 10.4
17 bone disease 10.3
18 exostosis 10.3
19 chondroma 10.3
20 arthropathy 10.3
21 radiculopathy 10.3
22 osteochondritis dissecans 10.3
23 periostitis 10.3
24 myositis 10.3
25 fibroma 10.3
26 hyperostosis 10.3
27 myositis ossificans 10.3
28 muscular atrophy 10.3
29 enchondroma 10.3
30 rare tumor 10.3
31 carpal tunnel syndrome 10.2
32 reflex sympathetic dystrophy 10.2
33 aneurysmal bone cysts 10.2
34 tendinitis 10.2
35 algoneurodystrophy 10.2
36 epicondylitis 10.2
37 enthesopathy 10.2
38 spondylolysis 10.2
39 cellulitis 10.2
40 spindle cell sarcoma 10.2
41 juvenile rheumatoid arthritis 10.2
42 osteoarthritis 10.2
43 exophthalmos 10.2
44 osteochondroma 10.2
45 paresthesia 10.2
46 avascular necrosis 10.2
47 spondylolisthesis 10.1
48 chronic recurrent multifocal osteomyelitis 10.1
49 ewing sarcoma 10.1
50 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1

Graphical network of the top 20 diseases related to Osteoid Osteoma:



Diseases related to Osteoid Osteoma

Symptoms & Phenotypes for Osteoid Osteoma

Human phenotypes related to Osteoid Osteoma:

31
# Description HPO Frequency HPO Source Accession
1 osteoma 31 HP:0100246
2 osteoid osteoma 31 HP:0030433

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Skel:
osteoid osteoma

Clinical features from OMIM®:

259550 (Updated 20-May-2021)

UMLS symptoms related to Osteoid Osteoma:


pain

Drugs & Therapeutics for Osteoid Osteoma

Drugs for Osteoid Osteoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zoledronic Acid Approved Phase 3 118072-93-8 68740
2 Pharmaceutical Solutions Phase 3
3 Diphosphonates Phase 3
4 Analgesics Phase 3
5 Anesthetics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Osteoid Osteoma With MR Guided High Intensity Focused Ultrasound Unknown status NCT02302651 Phase 2, Phase 3
2 Phase III Study to Compare the Effectiveness of Magnetic Resonance Guided Focused Ultrasound With Computed Tomography Guided Radiofrequency Ablation for Treatment of Osteoid Osteomas Recruiting NCT02923011 Phase 3
3 Non-inferiority Trial of Three Cycles of Zoledronic Acid Versus Percutaneous Thermal Ablation in Osteoid Osteoma Recruiting NCT02739555 Phase 3 Acide Zoledronique
4 Pivotal / Phase II Clinical Trial of Magnetic Resonance-Guided Focused Ultrasound (MR-HIFU) Treatment of Painful Osteoid Osteoma in Children and Young Adults Recruiting NCT04658771 Phase 2
5 Treatment Outcome After Surgical Treatment of Osteoid Osteoma, a Retrospective Study Completed NCT01466010
6 OsteoCool Tumor Ablation Post-Market Study (OPuS One) Completed NCT03249584
7 Magnetic Resonance-Guided High Intensity Focused Ultrasound for Pain Management of Osteoid Osteoma and Benign Bone Tumors in Children and Young Adults Completed NCT02618369
8 Safety and Feasibility of MR-Guided High Intensity Focused Ultrasound (MR-HIFU) Ablation of Osteoid Osteoma in Children Active, not recruiting NCT02349971

Search NIH Clinical Center for Osteoid Osteoma

Genetic Tests for Osteoid Osteoma

Anatomical Context for Osteoid Osteoma

MalaCards organs/tissues related to Osteoid Osteoma:

40
Bone, Bone Marrow, Skin, Spinal Cord, Smooth Muscle, Eye, Colon

Publications for Osteoid Osteoma

Articles related to Osteoid Osteoma:

(show top 50) (show all 2361)
# Title Authors PMID Year
1
Bone Tumors Occurring in the Soft Tissues: A Review of the Clinical, Imaging, and Histopathologic Findings. 61
32665061 2021
2
Ischial osteoid osteoma: A cause of persistent hip pain in an adolescent patient with bilateral femoroacetabular impingement. 61
33680272 2021
3
Soft tissue recurrence of an osteoid osteoma: an exceptional observation. 61
32964242 2021
4
Osteoid Osteoma of the Atlas in a Boy: Clinical and Imaging Features-A Case Report and Review of the Literature. 61
33111305 2021
5
Differential Diagnosis of Facet Joint Disorders. 61
33481690 2021
6
A CT-free protocol to treat osteoid osteoma of the hip region in childhood and adolescence by percutaneous drilling and by hip arthroscopy. 61
33656954 2021
7
Osteoid osteoma: the great mimicker. 61
33683492 2021
8
A bicentric propensity score matching study comparing percutaneous computed tomography-guided radiofrequency Ablation to Magnetic Resonance-guided Focused Ultrasounds for the treatment of osteoid osteoma. 61
33775816 2021
9
Percutaneous computed tomography-guided radiofrequency ablation of a spinal osteoid osteoma abutting the dura: a case report and review of the literature. 61
33709268 2021
10
Percutaneous Ablative Therapies for the Management of Osteoid Osteomas: A Systematic Review and Meta-Analysis. 61
33709278 2021
11
Which is the optimal minimally invasive treatment for osteoid osteoma of the hip? A systematic review and proportional meta-analysis. 61
33563522 2021
12
Osteoid osteoma in the ankle and foot. An overview of 50 years of experience. 61
32370948 2021
13
[Three-year-old child with osteoid osteoma of the thumb: Diagnostic and therapeutic challenge]. 61
33588495 2021
14
Painless osteoid osteoma of the distal phalanx of a toe. 61
33623663 2021
15
[Osteoid osteoma: unusual cause of chronic pain in the wrist in a child]. 61
33458994 2021
16
Bone Tumours of the Talus: 18-Year Cohort of Patients With Rare Osteoid Lesions. 61
33791180 2021
17
Robotic-Assisted Tubular Transoral Parapharyngeal Approach to the Ventral Craniovertebral Junction. 61
33647934 2021
18
A preliminary comparative study of percutaneous CT-guided cryoablation with surgical resection for osteoid osteoma. 61
33520471 2021
19
Computed Tomography-Guided Radiofrequency Ablation of Osteoid Osteoma in Atypical Sites: Efficacy and Safety in a Large Case Series. 61
32111469 2021
20
Computed tomography-guided percutaneous radiofrequency and laser ablation for the treatment of osteoid osteoma - long-term follow-up from 5 to 10 years. 61
33708270 2021
21
Imaging-guided radiofrequency ablation of osteoid osteoma in typical and atypical sites: Long term follow up. 61
33735214 2021
22
Schwannoma of the lumbar spine, presenting with pain of the knee, like an osteoid osteoma, in a 10-year-old girl. 61
33489164 2021
23
Typical and Atypical Radiographic Features of Symptomatic Osteoblastoma in the Spine. 61
33065353 2021
24
Image-guided Cryotherapy for Musculoskeletal Tumors. 61
32842945 2021
25
Arthroscopic management of intra- and juxta-articular osteoid osteoma of the upper extremity: a systematic review of the literature. 61
32504238 2020
26
Surgical Management of Triquetral Osteoid Osteoma with Adjunct Tetracycline for Intraoperative Visualization: A Case Report. 61
33512929 2020
27
CT-guided Percutaneous Radiofrequency Ablation of Osteoid Osteoma with Double Nidi in One Session. 61
33397068 2020
28
Gamma Probe-Guided Surgery in Postoperative Recurrent Osteoid Osteoma of Left Index Finger. 61
33031247 2020
29
Intraarticular Osteoid Osteoma: MRI Characteristics and Clinical Presentation Before and After Radiofrequency Ablation Compared to Extraarticular Osteoid Osteoma. 61
32643768 2020
30
Osteoid osteoma of the hook of the hamate presenting as ulnar-sided wrist pain: A case report. 61
33101564 2020
31
Radiofrequency ablation vs microwave ablation for osteoid osteomas: long-term results. 61
32564104 2020
32
Impact of Magnetic Resonance Imaging (MRI) Findings on Management of Symptomatic Patients Following Radiofrequency Ablation (RFA) of Osteoid Osteoma (OO). 61
33235978 2020
33
Navigation assisted tubular resection of lumbar osteoid osteoma: how I do it. 61
32519162 2020
34
[Tumors affecting the temporomandibular joint - a literature review]. 61
33059872 2020
35
Primary Bone Tumors in North of Jordan. 61
33605114 2020
36
The malignant transformation of osteoid osteoma in the cervical spine to high-grade osteosarcoma: a case report and review of literature. 61
33140986 2020
37
Magnetic resonance imaging evaluation of osteoid osteoma: utility of the dark rim sign. 61
32845349 2020
38
Osteoid osteoma of the hip: imaging features. 61
32561955 2020
39
[An adolescent man with pain at night in his lower right leg]. 61
33201642 2020
40
CT-guided radiofrequency ablation for osteoid osteomas: a systematic review. 61
32518986 2020
41
Atypical Enostoses-Series of Ten Cases and Literature Review. 61
33065973 2020
42
MR Imaging of Osteoid Osteoma: Pearls and Pitfalls. 61
32980095 2020
43
Osteoid Osteoma of the Body of the Vertebrae Causing Painful Scoliosis. 61
33708686 2020
44
CT-guided radiofrequency ablation of osteoid osteoma: established concepts and new ideas. 61
32520586 2020
45
Percutaneous thermal ablation for treatment of osteoid osteoma: a systematic review and analysis. 61
32270226 2020
46
Osteoid osteoma in older adults: clinical success rate of percutaneous image-guided thermal ablation. 61
32586642 2020
47
Is radiofrequency ablation safe and effective in treating osteoid osteomas? A prospective single-center study with atypical cases. 61
33021151 2020
48
Juxta-Articular Osteoid Osteoma of the Calcaneus in a Young Athlete Treated With Subtalar Arthroscopic Excision: A Case Report. 61
32923501 2020
49
Computed tomography guided radiofrequency ablation of multifocal osteoid osteoma. 61
32577146 2020
50
Juvenile Osteoid Osteoma of the Distal Phalanx of the Second Digit. 61
32997767 2020

Variations for Osteoid Osteoma

Expression for Osteoid Osteoma

Search GEO for disease gene expression data for Osteoid Osteoma.

Pathways for Osteoid Osteoma

Pathways related to Osteoid Osteoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 PTGS2 FOS
2 12.32 PTGS2 FOS
3
Show member pathways
12.22 PTGS2 FOS
4
Show member pathways
12.17 PTGS2 FOS
5
Show member pathways
12.16 PTGS2 FOS
6
Show member pathways
12.15 PTGS2 FOS
7
Show member pathways
12.09 PTGS2 FOS
8
Show member pathways
12.08 PTGS2 FOS
9
Show member pathways
11.99 PTGS2 FOS
10 11.92 PTGS2 FOS
11
Show member pathways
11.88 PTGS2 FOS
12
Show member pathways
11.81 PTGS2 FOS
13
Show member pathways
11.81 PTGS2 FOS
14
Show member pathways
11.73 PTGS2 FOS
15
Show member pathways
11.68 PTGS2 FOS
16
Show member pathways
11.64 PTGS2 FOS
17 11.45 PTGS2 FOS
18
Show member pathways
11.38 PTGS2 FOS
19 11.31 PTGS2 FOS
20 11.2 PTGS2 FOS
21
Show member pathways
10.84 PTGS2 FOS
22
Show member pathways
10.42 PTGS2 FOS

GO Terms for Osteoid Osteoma

Cellular components related to Osteoid Osteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.62 PTGS2 FOS

Biological processes related to Osteoid Osteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.4 PTGS2 FOS
2 response to drug GO:0042493 9.37 PTGS2 FOS
3 cytokine-mediated signaling pathway GO:0019221 9.32 PTGS2 FOS
4 aging GO:0007568 9.26 PTGS2 FOS
5 response to lipopolysaccharide GO:0032496 9.16 PTGS2 FOS
6 response to organic cyclic compound GO:0014070 8.96 PTGS2 FOS
7 response to cytokine GO:0034097 8.62 PTGS2 FOS

Sources for Osteoid Osteoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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