MCID: OST011
MIFTS: 52

Osteomalacia

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteomalacia

MalaCards integrated aliases for Osteomalacia:

Name: Osteomalacia 12 76 53 55 15 73
Adult Rickets 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10573
ICD9CM 35 268.2
NCIt 50 C26838

Summaries for Osteomalacia

NIH Rare Diseases : 53 Osteomalacia is a disease that is characterized by a weakening of the bone, often due to a deficiency of vitamin D. This vitamin supports the development of the bones of the body, so when there are low levels of vitamin D, the bones are not strong enough. Symptoms of osteomalacia can include muscle weakness, bone pain, and walking with a waddling gait. Pain is especially likely to occur in the lower back, hips, and legs. The weakening of the bones may also cause them to easily fracture.  Osetomalacia can be caused by having a low level of vitamin D in the diet or lack of sun exposure. The condition may also be the result of an underlying disease such as celiac disease, or kidney or liver disorders.  Diagnosis of osteomalacia is possible through blood or urine tests to check for vitamin D levels or a bone biopsy. Treatment options include supplementing the diet with more vitamin D or calcium. Any underlying condition will also need to be treated.  

MalaCards based summary : Osteomalacia, also known as adult rickets, is related to oncogenic osteomalacia and hypophosphatasia. An important gene associated with Osteomalacia is DMP1 (Dentin Matrix Acidic Phosphoprotein 1), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A bone remodeling disease that has material basis in a vitamin D deficiency which results in softening located in bone.

Wikipedia : 76 Osteomalacia is the softening of the bones caused by impaired bone metabolism primarily due to... more...

Related Diseases for Osteomalacia

Diseases related to Osteomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 oncogenic osteomalacia 33.1 DMP1 FGF23 PHEX PTHLH SFRP4
2 hypophosphatasia 32.6 ALPL PHEX
3 autosomal recessive hypophosphatemic rickets 31.8 DMP1 FGF23 PHEX
4 hypophosphatemic rickets, x-linked dominant 31.1 DMP1 FGF23 PHEX SFRP4 VDR
5 hypophosphatasia, adult 30.7 ALPL BGLAP CALCA
6 raine syndrome 30.6 DMP1 FGF23
7 hypophosphatemic rickets, x-linked recessive 30.6 CYP24A1 DMP1 FGF23 PHEX SFRP4 VDR
8 rickets 30.6 ALPL BGLAP DMP1 FGF23 PHEX VDR
9 paraneoplastic syndromes 30.5 FGF23 PTHLH
10 hypophosphatemic rickets, autosomal dominant 29.8 FGF23 PHEX SFRP4
11 hypophosphatemic rickets with hypercalciuria, hereditary 29.4 DMP1 FGF23 PHEX SFRP4
12 hypophosphatemia 29.3 BGLAP DMP1 FGF23 PHEX SFRP4
13 renal osteodystrophy 29.2 BGLAP CALCA CASR FGF23 VDR
14 fibrous dysplasia 29.1 BGLAP CALCA FGF23
15 pseudohypoparathyroidism 28.7 BGLAP PTHLH
16 osteitis fibrosa 28.6 BGLAP CALCA CASR
17 hypoparathyroidism 27.9 BGLAP CASR FGF23 PTHLH
18 secondary hyperparathyroidism of renal origin 27.5 BGLAP CALCA CASR FGF23 VDR
19 primary hyperparathyroidism 26.7 BGLAP CALCA CASR FGF23 PTHLH VDR
20 hyperparathyroidism 26.6 BGLAP CALCA CASR FGF23 PHEX PTHLH
21 parathyroid adenoma 26.4 BGLAP CALCA CASR PTHLH VDR
22 bone disease 25.6 ALPL BGLAP CALCA CASR FGF23 PTHLH
23 osteoporosis 25.5 ALPL BGLAP CALCA CASR CYP24A1 FGF23
24 axial osteomalacia 12.5
25 osteomalacia, sclerosing, with cerebral calcification 11.9
26 fanconi renotubular syndrome 1 11.1
27 renal tubular acidosis, distal 11.1
28 renal tubular acidosis, distal, autosomal dominant 10.8
29 hypophosphatemic rickets, autosomal recessive, 1 10.8
30 vitamin d hydroxylation-deficient rickets, type 1a 10.8
31 dent disease 1 10.8
32 nephrolithiasis, x-linked recessive, with renal failure 10.8
33 hypophosphatemic rickets, autosomal recessive, 2 10.8
34 fanconi renotubular syndrome 2 10.8
35 fanconi renotubular syndrome 3 10.8
36 osteopetrosis 10.8
37 kienbock's disease 10.8
38 slc4a1-associated distal renal tubular acidosis 10.8
39 opsismodysplasia 10.7 FGF23 PHEX
40 familial tumoral calcinosis 10.6 FGF23 PHEX
41 arterial calcification of infancy 10.6 FGF23 PHEX
42 hypervitaminosis d 10.6 FGF23 VDR
43 enthesopathy 10.4 DMP1 FGF23 PHEX
44 impaired renal function disease 10.4 BGLAP FGF23
45 fanconi syndrome 10.3
46 pyle disease 10.2 PTHLH SFRP4
47 extraskeletal chondroma 10.1 BGLAP PTHLH
48 adult syndrome 10.1
49 renal tubular acidosis 10.1
50 hepatitis 10.1

Comorbidity relations with Osteomalacia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Osteoporosis

Graphical network of the top 20 diseases related to Osteomalacia:



Diseases related to Osteomalacia

Symptoms & Phenotypes for Osteomalacia

MGI Mouse Phenotypes related to Osteomalacia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 SFRP4 VDR PTHLH FGF23 CASR CYP24A1
2 homeostasis/metabolism MP:0005376 10.1 SFRP4 VDR PTHLH CASR NR1I2 CYP24A1
3 hematopoietic system MP:0005397 10.03 SFRP4 VDR PTHLH FGF23 CASR PHEX
4 digestive/alimentary MP:0005381 10.02 SFRP4 VDR PTHLH CASR PHEX ALPL
5 immune system MP:0005387 9.97 SFRP4 VDR PTHLH FGF23 CASR PHEX
6 mortality/aging MP:0010768 9.91 PTHLH SFRP4 VDR FGF23 NR1I2 CASR
7 craniofacial MP:0005382 9.89 PTHLH VDR ALPL PHEX DMP1
8 limbs/digits/tail MP:0005371 9.87 SFRP4 VDR PTHLH PHEX DMP1 ALPL
9 renal/urinary system MP:0005367 9.76 SFRP4 VDR CASR PHEX CYP24A1 DMP1
10 reproductive system MP:0005389 9.5 SFRP4 VDR PTHLH FGF23 NR1I2 CYP24A1
11 skeleton MP:0005390 9.28 SFRP4 VDR PTHLH CASR PHEX CYP24A1

Drugs & Therapeutics for Osteomalacia

Drugs for Osteomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 1406-16-2
3
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 67-97-0 6221 5280795
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
5 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
7 Immunoglobulin G Phase 4,Phase 2,Phase 3,Phase 1
8 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1
9 Ergocalciferols Phase 4,Phase 1,Phase 2,Not Applicable
10 Hormones Phase 4,Phase 3,Phase 1
11 Micronutrients Phase 4,Phase 1,Phase 2,Not Applicable
12 Trace Elements Phase 4,Phase 1,Phase 2,Not Applicable
13 Vitamins Phase 4,Phase 1,Phase 2,Not Applicable
14 Retinol palmitate Phase 4
15 Calciferol Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable
16 Vitamin D2 Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable
17 retinol Nutraceutical Phase 4
18
Teriparatide Approved, Investigational Phase 3 52232-67-4 16133850
19
Bazedoxifene Approved, Investigational Phase 3 198481-32-2
20
Denosumab Approved Phase 3,Phase 2 615258-40-7
21 Mitogens Phase 3,Phase 2,Phase 1
22 Estrogen Receptor Modulators Phase 3
23 Estrogens Phase 3
24 Hormone Antagonists Phase 3,Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
26 Selective Estrogen Receptor Modulators Phase 3
27 Antibodies, Monoclonal Phase 3,Phase 2
28
Somatostatin Approved, Investigational Phase 2,Early Phase 1 38916-34-6, 51110-01-1 53481605
29
Tetracycline Approved, Vet_approved Phase 2 60-54-8 5353990
30 Calcifediol Phase 1, Phase 2 19356-17-3
31 Cariostatic Agents Phase 2
32 Fluorides Phase 2
33 Protective Agents Phase 2
34 Anti-Bacterial Agents Phase 2
35 Anti-Infective Agents Phase 2
36 Calcium, Dietary Phase 1, Phase 2,Not Applicable
37 Calcimimetic Agents Phase 1
38 Cinacalcet Hydrochloride Phase 1
39
Menthol Approved Early Phase 1 2216-51-5 16666
40
Acetylcholine Approved Not Applicable 51-84-3 187
41
Nitroprusside Approved, Investigational Not Applicable 15078-28-1 11963622
42
Iron Approved 7439-89-6 23925
43
Cimetidine Approved, Investigational 51481-61-9 2756
44
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
45 Pharmaceutical Solutions Early Phase 1
46 Anabolic Agents
47 Diphosphonates
48 Hydroxycholecalciferols
49 Arginine Vasopressin
50 Liver Extracts

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4 25 OH vitamin D
2 A Single Wintertime Dose of Vitamin D3 to Prevent Winter Decline in Vitamin D Status in Healthy Adults Completed NCT01924910 Phase 4
3 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Completed NCT02238418 Phase 4 Cholecalciferol vial (100 000 UI)
4 Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in Japan Completed NCT02531867 Phase 4
5 A Pilot Study to Evaluate the Effect of Forsteo (Teriparatide, 1-34-rh-PTH) in Anorexia Nervosa Patients With Low Bone Mineral Density and Increased Bone Fagility (FAN-Trial) Unknown status NCT01801397 Phase 3 osteoanabolic therapy
6 Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP) Completed NCT01176266 Phase 2, Phase 3 asfotase alfa
7 Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women Completed NCT00205777 Phase 3 Bazedoxifene Acetate
8 Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis Completed NCT00523341 Phase 3
9 A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia Active, not recruiting NCT03233126 Phase 3 KRN23
10 Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02537431 Phase 3
11 Combination Osteogenic Therapy in Established Osteoporosis Completed NCT00018447 Phase 2 PTH 1-34;MFPSR-fluoride
12 Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP) Completed NCT01163149 Phase 2 asfotase alfa;asfotase alfa
13 A Transiliac Crest Bone Histology and Histomorphometry Study in Postmenopausal Women With Low Bone Mass or Osteoporosis Previously Treated With Denosumab Completed NCT00887965 Phase 2 Previous denosumab
14 Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP) Completed NCT00952484 Phase 2
15 Nursing-Home Residents Given Bread Fortified With Vitamin D3 Completed NCT00789503 Phase 1, Phase 2
16 Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP) Completed NCT01205152 Phase 2
17 Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP) Completed NCT01203826 Phase 2
18 Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP) Completed NCT00744042 Phase 1, Phase 2
19 A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome Active, not recruiting NCT02722798 Phase 2 KRN23
20 Study of KRN23 in Adult Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS) Active, not recruiting NCT02304367 Phase 2 KRN23
21 Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors Active, not recruiting NCT01967537 Phase 2 68Gallium DOTATATE
22 BGJ398 for the Treatment of Tumor-Induced Osteomalacia Not yet recruiting NCT03510455 Phase 2 BGJ398
23 Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP) Withdrawn NCT00894075 Phase 2
24 A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia Completed NCT02181764 Phase 1 KRN23
25 Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP) Completed NCT00739505 Phase 1
26 Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets) Terminated NCT01748812 Phase 1 Osteomalacia
27 68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia Unknown status NCT01524016 Early Phase 1 68Ga-DOTATATE
28 Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia Unknown status NCT02331966
29 Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia Unknown status NCT01660308
30 Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy Unknown status NCT02814591
31 Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP) Approved for marketing NCT02496689
32 Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia Completed NCT00099762
33 Serum FGF-23 and Vitamin D Deficiency Completed NCT01102751
34 Maternal and Infant Vitamin Status During the First Nine Months of Infant Life Completed NCT02548520
35 Serum Sclerostin Level & Treatment of Vitamin D Deficiency Completed NCT01553344
36 Vitamin D, Bones, Nutritional and Cardiovascular Status Completed NCT01832623 Not Applicable
37 Does Intravenous Iron Therapy Decrease Serum Phosphorous Levels? Completed NCT02420119
38 Vitamin D Supplementation and Sunlight Exposure in Brazilian Women Living in Opposite Latitudes (The D-SOL Study) Completed NCT03318029 Not Applicable
39 APOSTrophe Study (Parenteral Nutrition and Bone Trophicity) Impact of a Long-term Parenteral Nutrition on Bone Metabolism Measured by High Resolution Peripheral Quantitative Computer Tomography (HR-pQCT) in Children and Young Adults Completed NCT02368496 Not Applicable
40 Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation Completed NCT01079923 Not Applicable
41 The Effect of Vitamin D Repletion on Small Low Density Lipoprotein (LDL) Particle Number in Subjects at Elevated Cardiovascular Risk Completed NCT01008384 Not Applicable
42 Replacement of Vitamin D in Patients With Active Tuberculosis Completed NCT01130311 Not Applicable Cholecalciferol;Saline injection
43 Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism Completed NCT03027349
44 Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09 Completed NCT02235493
45 Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP) Completed NCT02104219
46 A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP) Completed NCT01419028
47 Evaluation and Treatment of Skeletal Diseases Recruiting NCT00024804
48 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
49 Hypovitaminosis D Prediction Score Recruiting NCT02822651 Not Applicable
50 Natural History Study of Patients With Hypophosphatasia (HPP) Recruiting NCT02237625

Search NIH Clinical Center for Osteomalacia

Genetic Tests for Osteomalacia

Anatomical Context for Osteomalacia

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomalacia:

19
Bone

MalaCards organs/tissues related to Osteomalacia:

41
Bone, Liver, Kidney, Testes, Prostate, Thyroid, Brain

Publications for Osteomalacia

Articles related to Osteomalacia:

(show top 50) (show all 753)
# Title Authors Year
1
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil. ( 29343941 )
2018
2
Hypophosphatemic Osteomalacia with Multiple Bone Fractures: ADV-Induced Fanconi's Syndrome. ( 29399572 )
2018
3
Tumora89induced hypophosphatemic osteomalacia as a rare cause of bone pain. ( 29600968 )
2018
4
Severe FGF23-based hypophosphataemic osteomalacia due to ferric carboxymaltose administration. ( 29298794 )
2018
5
Osteomalacia, renal Fanconi syndrome, and bone tumor. ( 29614898 )
2018
6
Phosphaturic Mesenchymal Tumor Without Osteomalacia: Additional Confirmation of the "Non-Phosphaturic" Variant, with Emphasis on the Roles of FGF23 Chromogenic in situ Hybridization and FN1-FGFR1 Fluorescence in situ Hybridization. ( 29514106 )
2018
7
A Challenging Case of Tumor-Induced Osteomalacia: Pathophysiological and Clinical Implications. ( 29736882 )
2018
8
Clinical and laboratory features of patients with osteomalacia initially presenting with neurological manifestations. ( 29623355 )
2018
9
Correction to: Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in SjAPgren's syndrome: a case report and review of the literature. ( 29380163 )
2018
10
Maxillary tumour-induced osteomalacia. ( 29571670 )
2018
11
Occult phosphaturic mesenchymal tumor of femur cortex causing oncogenic osteomalacia: Diagnostic challenges and clinical outcomes. ( 29442350 )
2018
12
Oncogenic Osteomalacia. ( 29319792 )
2018
13
An Uncommon Case of Bilateral Pathologic Hip Fractures: Antiviral Drug-induced Osteomalacia in a Patient with Hepatitis B. ( 29896460 )
2018
14
Tumor-Induced Osteomalacia Caused by a Parotid Basal Cell Adenoma Detected by 68Ga-DOTANOC PET/CT. ( 29659384 )
2018
15
Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series. ( 29769119 )
2018
16
Tumor-induced hypophosphatemic osteomalacia: description of 2 cases. ( 29776656 )
2018
17
SjAPgren's Syndrome Associated with Fanconi's Syndrome and Osteomalacia. ( 29610453 )
2018
18
Diagnostic performance and impact on patient management of <sup>68</sup>Ga-DOTA-TOC PET/CT for detecting osteomalacia-associated tumours. ( 29532101 )
2018
19
Acquired hypophosphatemic osteomalacia is easily misdiagnosed or neglected by rheumatologists: A report of 9 cases. ( 29904418 )
2018
20
Identification of a novel loss-of-function PHEX mutation, Ala720Ser, in a sporadic case of adult-onset hypophosphatemic osteomalacia. ( 28982589 )
2018
21
Targeted resequencing of phosphorus metabolisma89related genes in 86 patients with hypophosphatemic rickets/osteomalacia. ( 29901142 )
2018
22
The Findings on Bone Scintigraphy in Patients With Suspected Tumor-Induced Osteomalacia Should Not Be Overlooked. ( 29504962 )
2018
23
Osteomalacia Due to Drug-Induced Fanconi Syndrome. ( 29575761 )
2018
24
Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach. ( 29655998 )
2018
25
Tumor-induced osteomalacia in association with PTEN-negative Cowden syndrome. ( 29380000 )
2018
26
Bone histomorphometry in the evaluation of osteomalacia. ( 29955631 )
2018
27
Prevention of rickets and osteomalacia in the UK: political action overdue. ( 29661756 )
2018
28
Hypocalcemia and osteomalacia after bariatric surgery. ( 29263738 )
2017
29
Is there any link between tumor-induced osteomalacia and psoriasis? A case report. ( 28852641 )
2017
30
Definitive surgical treatment of osteomalacia induced by skull base tumor and determination of the half-life of serum fibroblast growth factor 23. ( 28768937 )
2017
31
Selective blood sampling for FGF-23 in tumor-induced osteomalacia. ( 29026610 )
2017
32
Correction to Oncogenic osteomalacia: role of Ga-68 DOTANOC PET/CT scan in identifying the culprit lesion and its management. ( 29034744 )
2017
33
Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in SjAPgren's syndrome: a case report and review of the literature. ( 28725949 )
2017
34
Oncogenic Osteomalacia: An Approach to Diagnosis with a Case Report. ( 28571152 )
2017
35
A distinctive patchy osteomalacia characterises Phospho1-deficient mice. ( 28737011 )
2017
36
Iron Supplementation-Induced Phosphaturic Osteomalacia: FGF23 is the Culprit. ( 29281120 )
2017
37
The Foot That Broke Both Hips: A Case Report and Literature Review of Tumor-Induced Osteomalacia. ( 29104808 )
2017
38
Antiepileptic therapy, osteomalacia, and synchronous fractures: Don't lose looser zones. ( 29026776 )
2017
39
A case of oncogenic osteomalacia owing to inguinal tumor. ( 29744113 )
2017
40
Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B. ( 28851305 )
2017
41
A Case of an Insufficiency Fracture of the Medial Proximal Tibia Secondary to Osteomalacia Associated with Long-Term Saccharated Ferric Oxide Administration. ( 28744387 )
2017
42
A case report of phosphaturic mesenchymal tumor-induced osteomalacia. ( 29390586 )
2017
43
Tumour-induced osteomalacia. ( 28703216 )
2017
44
Tumor-induced osteomalacia. ( 29021995 )
2017
45
Tumour-induced osteomalacia. ( 28703220 )
2017
46
Pathological fractures in a patient with severe osteomalacia and hyperparathyroidism: a multidisciplinary challenge. ( 28840440 )
2017
47
Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones. ( 28081649 )
2017
48
Tumor-induced Osteomalacia: A Sherlock Holmes Approach to Diagnosis and Management. ( 28713755 )
2017
49
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
50
Successful CT guided cryoablation of phosphaturic mesenchymal tumor in the soft tissues causing tumor-induced osteomalacia: a case report. ( 27921126 )
2017

Variations for Osteomalacia

Expression for Osteomalacia

Search GEO for disease gene expression data for Osteomalacia.

Pathways for Osteomalacia

GO Terms for Osteomalacia

Cellular components related to Osteomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ALPL BGLAP CALCA FGF23 PTHLH SFRP4
2 extracellular region GO:0005576 9.17 ALPL BGLAP CALCA DMP1 FGF23 PTHLH

Biological processes related to Osteomalacia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 CASR NR1I2 SFRP4 VDR
2 cellular protein metabolic process GO:0044267 9.77 CALCA DMP1 FGF23
3 osteoblast differentiation GO:0001649 9.72 ALPL BGLAP CYP24A1
4 cellular calcium ion homeostasis GO:0006874 9.71 CALCA CASR VDR
5 ossification GO:0001503 9.7 BGLAP CASR DMP1
6 skeletal system development GO:0001501 9.65 ALPL BGLAP PHEX PTHLH VDR
7 lipid homeostasis GO:0055088 9.61 NR1I2 VDR
8 response to lipid GO:0033993 9.59 NR1I2 VDR
9 regulation of bone mineralization GO:0030500 9.58 BGLAP FGF23
10 vasodilation GO:0042311 9.58 CALCA CASR
11 osteoblast development GO:0002076 9.57 BGLAP PTHLH
12 bone mineralization GO:0030282 9.54 BGLAP PHEX PTHLH
13 cellular response to parathyroid hormone stimulus GO:0071374 9.51 FGF23 PHEX
14 vitamin D metabolic process GO:0042359 9.5 CYP24A1 FGF23 VDR
15 phosphate ion homeostasis GO:0055062 9.49 FGF23 SFRP4
16 vitamin D receptor signaling pathway GO:0070561 9.48 CYP24A1 VDR
17 vitamin D catabolic process GO:0042369 9.46 CYP24A1 FGF23
18 biomineral tissue development GO:0031214 9.46 ALPL BGLAP DMP1 PHEX
19 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.43 FGF23 VDR
20 response to sodium phosphate GO:1904383 9.4 FGF23 PHEX
21 response to vitamin D GO:0033280 9.26 ALPL BGLAP CYP24A1 PHEX
22 cellular response to vitamin D GO:0071305 8.92 BGLAP CASR FGF23 PHEX

Molecular functions related to Osteomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 9.16 NR1I2 VDR
2 transcription factor activity, RNA polymerase II transcription factor binding GO:0001076 8.96 NR1I2 VDR
3 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 8.62 NR1I2 VDR

Sources for Osteomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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