Osteomyelitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OST017 MIFTS: 63	Osteomyelitis Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis ¹¹ ¹⁹ ⁷⁵ ²⁸ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹ ³¹

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the musculoskeletal system and connective tissue

Other osteopathies

Osteomyelitis

Osteomyelitis, unspecified

External Ids:

Disease Ontology ¹¹ DOID:1019

ICD9CM ³⁴ 730.1

MeSH ⁴³ D010019

SNOMED-CT ⁶⁸ 203181001

ICD10 ³¹ M86 M86.9

EFO ¹⁶ EFO_0003102

UMLS ⁷¹ C0008707 C0029443

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Summaries for Osteomyelitis

GARD: ¹⁹ Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system.

MalaCards based summary: Osteomyelitis is related to sapho syndrome and chronic recurrent multifocal osteomyelitis, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clonidine and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Disease Ontology: ¹¹ A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia: ⁷⁵ Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

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Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1588)

#	Related Disease	Score	Top Affiliating Genes
1	sapho syndrome	32.2	TNF LPIN2 IL1RN FBLIM1 CXCL8 CRP
2	chronic recurrent multifocal osteomyelitis	32.0	TNFSF11 TNF NLRP3 LPIN2 IL6 IL1RN
3	osteopetrosis	31.7	TNFSF11 TNF IFNG CTSK ACP5
4	osteopetrosis, autosomal dominant 2	31.7	TNFSF11 CTSK ACP5
5	serum amyloid a amyloidosis	31.5	TNF NLRP3 IL6 CRP
6	septic arthritis	31.5	TNFSF11 TNF TLR2 PPP3CA IL6 IL1B
7	epidural abscess	31.3	IFNG CRP
8	osteonecrosis	31.2	IL10 BMP2 ACP5
9	toxic shock syndrome	31.1	TNF TLR2 IL6 IL1RN IL1B IL1A
10	actinomycosis	31.1	TNF IL10 CRP
11	cryptococcosis	31.1	TNF IL10 IFNG
12	cellulitis	31.0	TNFSF11 TNF IL6 IL1B CXCL8 CRP
13	haemophilus influenzae	31.0	TNF TLR2 IL1B CXCL8
14	peripheral vascular disease	31.0	TNF IL6 IL1B CRP
15	infective endocarditis	31.0	PPP3CA IL6 CXCL8 CRP
16	myositis	31.0	TNF IL6 IL1B IL1A IFNG
17	back pain	31.0	IL6 IL1RN IL1B IL10 CXCL8 CRP
18	macs syndrome	31.0	TNF IL10 IFNGR1 IFNG
19	periostitis	30.9	TNF LPIN2 IL1RN IL1B IL1A CRP
20	aspergillosis	30.9	TNF TLR2 IL6 IL1RN IL1B IL1A
21	fasciitis	30.9	TNF IL6 IL1RN IFNG CXCL8
22	mucormycosis	30.9	TNF IL6 IL10 IFNG CRP
23	bone disease	30.9	TNFSF11 TNF IL6 CTSK BMP2 ACP5
24	skeletal tuberculosis	30.8	IFNG CRP
25	melioidosis	30.8	TNF TLR2 IL6 IL10 IFNG
26	decubitus ulcer	30.8	TNF IL6 IL1B IL10 CXCL8 CRP
27	deficiency anemia	30.8	TNF IL6 IL1B IL10 CRP
28	endocarditis	30.8	TNF TLR2 IL6 IL1A IL10 IFNG
29	tenosynovitis	30.7	TNF IL6 IL1B CRP
30	pustulosis of palm and sole	30.7	TNF LPIN2 IL1RN CXCL8 CRP
31	blastomycosis	30.7	TNF IL6 CRP
32	spondylitis	30.7	TNFSF11 TNF IL6 IL1B IL10 IFNG
33	mycobacterium chelonae	30.7	TLR2 CXCL8
34	inflammatory bowel disease 1	30.7	TNF TLR2 IL6 IL1B IL10
35	alcohol use disorder	30.7	TNF IL6 IL1B CRP
36	smallpox	30.7	TNF IL1RN IL1B IFNG
37	bursitis	30.7	TNF IL6 IL1B CRP
38	compartment syndrome	30.6	TNF IL6 CRP
39	bell's palsy	30.6	TNF IL6 CRP
40	adult syndrome	30.6	TNF IL6 CRP
41	myelitis	30.6	TNF IL6 IL10 CXCL8
42	urinary tract infection	30.6	TNF TLR2 IL6 IL1B IL10 CXCL8
43	syphilis	30.6	TNF TLR2 CRP
44	q fever	30.6	TNF TLR2 IL6 IL1B IL10 IFNG
45	chickenpox	30.6	TNF IL6 IL1B IL10 IFNG CRP
46	necrotizing fasciitis	30.6	TNF IL6 IL1B CXCL8 CRP
47	mycobacterium marinum	30.6	TLR2 CXCL8
48	aortic aneurysm	30.6	TNF IL6 IL1B IL10 CXCL8 CRP
49	invasive aspergillosis	30.6	TNF TLR2 IL6 IL10 CRP
50	acquired immunodeficiency syndrome	30.5	TNF IL6 IL1B IL10 IFNG CRP

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Decubitus Ulcer
Deficiency Anemia	Heart Disease
Hypertension, Essential	Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:

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Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:

bone pain; pain in limb

GenomeRNAi Phenotypes related to Osteomyelitis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.14	ACP5 BMP2 CASP1 CRP CTSK CXCL8
2	no effect	GR00402-S-2	10.14	ACP5 CASP1 CRP IFNG IFNGR1 IL10
3	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.73	CXCL8 IL10 IL1A IL1B NLRP3 TNF
4	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.73	CASP1 CXCL8 IL10 IL1B NLRP3 TNF

MGI Mouse Phenotypes related to Osteomyelitis:

⁴⁵ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.44	BMP2 CASP1 CRP CTSK IFNG IFNGR1
2	growth/size/body region	MP:0005378	10.37	BMP2 CASP1 CTSK FBLIM1 IFNG IL10
3	nervous system	MP:0003631	10.36	BMP2 CASP1 CTSK IFNG IFNGR1 IL10
4	immune system	MP:0005387	10.35	ACP5 BMP2 CASP1 CRP CTSK FBLIM1
5	neoplasm	MP:0002006	10.26	CASP1 IFNG IFNGR1 IL10 IL1A IL1B
6	cardiovascular system	MP:0005385	10.22	BMP2 CASP1 CRP IFNG IFNGR1 IL10
7	cellular	MP:0005384	10.21	BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
8	endocrine/exocrine gland	MP:0005379	10.18	CASP1 CTSK FBLIM1 IFNG IFNGR1 IL10
9	digestive/alimentary	MP:0005381	10.16	BMP2 CASP1 CTSK IFNG IFNGR1 IL10
10	liver/biliary system	MP:0005370	10.14	IFNG IFNGR1 IL10 IL6 LPIN2 NLRP3
11	limbs/digits/tail	MP:0005371	10.13	ACP5 BMP2 CTSK FBLIM1 IL10 NLRP3
12	hematopoietic system	MP:0005397	10.11	ACP5 BMP2 CASP1 CTSK FBLIM1 IFNG
13	reproductive system	MP:0005389	10.1	BMP2 CASP1 CTSK IFNG IFNGR1 IL10
14	skeleton	MP:0005390	10.1	ACP5 BMP2 CTSK FBLIM1 IFNG IFNGR1
15	mortality/aging	MP:0010768	9.8	BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
16	integument	MP:0010771	9.4	CASP1 IFNG IFNGR1 IL10 IL1A IL1B

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Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Clonidine

Approved

Phase 4

4205-91-8, 4205-90-7

2803 20179

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530

Cefazolin

Approved

Phase 4

25953-19-9

33255

Dalbavancin

Approved, Investigational

Phase 4

171500-79-1

16134627

Nafcillin

Approved, Investigational

Phase 4

985-16-0, 147-52-4

8982

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Clavulanic acid

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Dicloxacillin

Approved, Investigational, Vet_approved

Phase 4

3116-76-5

18381

Flucloxacillin

Approved, Investigational

Phase 4

5250-39-5, 34214-51-2

21319

Cephalexin

Approved, Investigational, Vet_approved

Phase 4

15686-71-2

27447

Tobramycin

Approved, Investigational

Phase 4

32986-56-4

36294

Oritavancin

Approved, Investigational

Phase 4

171099-57-3

16136912

Vancomycin

Approved

Phase 4

1404-90-6

14969

Linezolid

Approved, Investigational

Phase 4

165800-03-3

441401

Daptomycin

Approved, Investigational

Phase 4

103060-53-3

16129629

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Riboflavin

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4

83-88-5

493570

Adrenergic alpha-Agonists

Phase 4

Adrenergic Agonists

Phase 4

Antihypertensive Agents

Phase 4

Sympatholytics

Phase 4

Folate

Phase 4

Vitamin B9

Phase 4

beta-Lactamase Inhibitors

Phase 4

Vitamin B Complex

Phase 4

Coagulase

Phase 4

Dermatologic Agents

Phase 4

Antitubercular Agents

Phase 4

Amoxicillin-Potassium Clavulanate Combination

Phase 4

Vitamins

Phase 4

Trace Elements

Phase 4

Photosensitizing Agents

Phase 4

Vitamin B2

Phase 4

Micronutrients

Phase 4

Gentamicins

Phase 4

Analgesics, Opioid

Phase 4

Benzocaine

Approved, Investigational

Phase 3

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 3

1401-55-4

16129878 16129778

Ertapenem

Approved, Investigational

Phase 3

153832-46-3

150610

Tigecycline

Approved

Phase 3

220620-09-7

5282044

Ciprofloxacin

Approved, Investigational

Phase 3

85721-33-1, 93107-08-5

2764

Trimethoprim

Approved, Vet_approved

Phase 3

738-70-5

5578

Sulfamethoxazole

Approved

Phase 3

723-46-6

5329

Clindamycin

Approved, Vet_approved

Phase 3

18323-44-9, 24729-96-2

29029

Levofloxacin

Approved, Investigational

Phase 3

100986-85-4

149096

Cefotaxime

Approved

Phase 3

63527-52-6

5742673 456256

Fusidic acid

Approved, Investigational

Phase 3

6990-06-3

3000226

Ofloxacin

Approved

Phase 3

82419-36-1

4583

Rifampicin

Approved

Phase 3

13292-46-1

135512673 5381226 135900090

Doxycycline

Approved, Investigational, Vet_approved

Phase 3

564-25-0

54671203

Interventional clinical trials:

(show top 50) (show all 88)

#	Name	Status	NCT ID	Phase	Drugs
1	CERAMENT™\|G - Bone Healing and Re-infection Prophylaxis	Unknown status	NCT02128256	Phase 4
2	Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study	Completed	NCT02123628	Phase 4	duration of the antibiotic therapy
3	Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis	Completed	NCT00764114	Phase 4	antibiotic
4	Clonidine for Tourniquet-related Pain in Children: A Pilot Study	Recruiting	NCT04564430	Phase 4	Catapresan
5	Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial	Recruiting	NCT04141787	Phase 4	Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
6	CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid)	Recruiting	NCT03012529	Phase 4	Rifampin;Riboflavin Placebo
7	Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections	Recruiting	NCT03426761	Phase 4	Dalbavancin;Vancomycin
8	Oral-only Antibiotics for Bone and Joint Infections in Children - A Nationwide Randomized Controlled Trial	Recruiting	NCT04563325	Phase 4	Oral co-amoxiclav or oral dicloxacillin only;IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
9	BonE and Joint Infections - Simplifying Treatment in Children Trial	Recruiting	NCT04538053	Phase 4	Oral cefalexin only;IV cefazolin or IV flucloxacillin followed by oral cefalexin
10	Anchoring Intermittent Long Acting Antimicrobials to Medication for Opioid Use Disorder Treatment to Facilitate Structured Transitions of Care for People Who Use Drugs Admitted to the Hospital With Invasive Infections	Not yet recruiting	NCT05521880	Phase 4	Oritavancin
11	Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial	Not yet recruiting	NCT05421741	Phase 4	Antibiotic coated intramedullary Nail
12	Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients	Terminated	NCT01734694	Phase 4	Vancomycin;Ceftaroline;Daptomycin;Linezolid
13	Comparison of Medical and Medical-surgical Management of Diabetic Foot Osteomyelitis	Withdrawn	NCT00578890	Phase 4
14	Ceftaroline in the Treatment of Bone and Joint Infections	Withdrawn	NCT02005068	Phase 4	Ceftaroline
15	A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms	Completed	NCT01922011	Phase 3	Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
16	A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline Versus Ertapenem for the Treatment of Foot Infections in Subjects With Diabetes	Completed	NCT00366249	Phase 3	Tigecycline;Ertapenem
17	Three Weeks Versus Six Weeks Antibiotic Therapy for Nonsurgically Treated Diabetic Foot Osteomyelitis : a Multicenter, Randomized, Open-label and Controlled Study	Not yet recruiting	NCT05074147	Phase 3	Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks
18	A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to Gram-Positive Organisms	Withdrawn	NCT02344511	Phase 3	Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
19	Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial	Unknown status	NCT02594878	Phase 2	Pamidronatdinatrium
20	Phase 1/2 Trial of Ceftaroline for the Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children	Completed	NCT02335905	Phase 1, Phase 2	Ceftaroline Fosamil
21	A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthetic Hip or Knee Joint Caused by Staphylococci	Completed	NCT00428844	Phase 2	daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
22	A Phase 2, Single-center, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-Positive Organisms	Completed	NCT02685033	Phase 2	Dalbavancin;Comparator
23	Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI	Completed	NCT01336803	Phase 2	Feraheme
24	A Phase IIa Randomized, Parallel Group, Double-blind, Repeat Dose, Investigating the Safety, Tolerability, and Efficacy of Phage Treatment and Standard of Care Antimicrobials for Patients With Diabetic Foot Osteomyelitis	Recruiting	NCT05177107	Phase 2
25	A Multi-center, Randomized, Controlled Feasibility Trial of Stimulan-VG and Debridement With an Abbreviated Course of Systemic Antibiotics to Debridement and a Full Course of Systemic Antibiotics for the Treatment of Diabetic Foot Osteomyelitis of the Forefoot	Not yet recruiting	NCT05539963	Phase 2	Stimulan-VG;Systemic Antibiotics
26	Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS)	Terminated	NCT02168816	Phase 2	Intravenous Antibacterial Agent;Oral Antibacterial Agent
27	A Phase 2, Multicenter, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-positive Organisms	Terminated	NCT03091439	Phase 2	Dalbavancin;Standard of Care
28	Exploration of the Use of [124I]FIAU Positron Emission Tomography-Computed Tomography Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection.	Terminated	NCT01764919	Phase 2
29	Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections	Completed	NCT03802552	Phase 1	Cefadroxil;Cephalexin
30	Plasma-Based Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections	Unknown status	NCT03846804
31	Prospective Randomized Clinical Trial Comparing Efficacy Surgical Versus Medical Treatment of Osteomyelitis in Diabetic Foot Ulcers	Unknown status	NCT01137903		Ciprofloxacin;Amoxicillin-Potassium Clavulanate Combination;Sulfamethoxazole trimethoprim
32	Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis: a Randomized Multicentre Trial	Unknown status	NCT04436328
33	A Prospective, Randomized Trial Comparing Vancomycin With Trimethoprim/Sulfamethoxazole for the Treatment of MRSA Osteomyelitis	Unknown status	NCT00324922		trimethoprim-sulfamethoxazole;vancomycin
34	The Effect of Fungal Infection on the Outcome Among Diabetic Patients With Foot Osteomyelitis	Unknown status	NCT04041739
35	Assessment of White Blood Cell SPECT/CT in Monitoring Antibiotic Treatment in Patients With Diabetic Foot Osteomyelitis	Unknown status	NCT02927678
36	Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis	Unknown status	NCT01473979
37	Sensitivity, Specificity and Predictive Value of High Resolution (B-Mode) Ultrasonography (HRUS) for the Detection of Osteomyelitis in Chronic Wound Patients	Unknown status	NCT02198755
38	Development of Risk Score Model and Decision Tree Algorithm for Predicting Bloodstream Infections (BSIs) or Other Invasive Infections With Carbapenem Resistant Klebisella Penumoniae (CRKp) in CRKp Colonized Patients (DETERMINE)	Unknown status	NCT04229511
39	The Registry of Hyperbaric Oxygen Therapy Treated Patients	Unknown status	NCT02483650
40	Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis	Completed	NCT02308774
41	Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis	Completed	NCT02165579
42	Hematogenous Osteomyelitis in Childhood Can Relapse Dozens of Years in Adulthood	Completed	NCT03898219
43	Pressure Ulcer-associated Osteomyelitis: Retrospective Evaluation of a Two-stage Surgical Strategy (Debridement With Vacuum-assisted Closure Therapy and Reconstruction) With Prolonged Antimicrobial Therapy	Completed	NCT03010293
44	Biofilm Formation Increases Treatment Failure in Staphylococcus Epidermidis Device-related Osteomyelitis in Human Patients	Completed	NCT02640937
45	Studying on the Difference Between Foot Osteomyelitis Patients With or Without Diabetes	Completed	NCT04240964
46	Determining of Independent Risk Factors for Three Critical Stages of the Diabetic Foot Infections Without Using the Well-known Classification Systems: Osteomyelitis, Amputation and Major Amputation	Completed	NCT02736253
47	SPONDIMMO : Multicentered Descriptive Prospective Study of Immobilization and Neurological Complication in Patients With Vertebral Osteomyelitis.	Completed	NCT04655950
48	Drug Delivery Devices for Osteomyelitis	Completed	NCT02968693		Vancomycin
49	Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis	Completed	NCT01125839
50	Inflammatory Biomarkers to Diagnose and Monitor Diabetic Foot Osteomyelitis	Completed	NCT04025853

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Ciprofloxacin

Cochrane evidence based reviews: osteomyelitis

Sources

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

#	Genetic test	Affiliating Genes
1	Osteomyelitis ²⁸

Sources

Anatomical Context for Osteomyelitis

Organs/tissues related to Osteomyelitis:

FMA: Bone, Bone Marrow

MalaCards : Bone, Bone Marrow, Spinal Cord, Skin, Prostate, Neutrophil, Heart

Sources

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 24824)

#	Title	Authors	PMID	Year
1	Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency. ⁵³ ⁶²	Marazzi MG...Casanova JL	19880337	2010
2	Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein-2 for vertebral osteomyelitis. ⁵³ ⁶²	Aryan HE...Ames CP	17233287	2007
3	RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. ⁵³ ⁶²	Montonen M...Konttinen YT	17032395	2006
4	Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. ⁵³ ⁶²	Meagher J...Filgueira L	15872059	2005
5	[The study of the antioxidant enzymes in erythrocytes in lung diseases]. ⁵³ ⁶²	Matskevich GN...Karelin AA	12838770	2003
6	Genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. ⁵³ ⁶²	Sasaki Y...Hara T	11865431	2002
7	Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. ⁵³ ⁶²	Elasri MO...Smeltzer MS	11792597	2002
8	A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. ⁵³ ⁶²	Allende LM...Arnaiz-Villena A	11139207	2001
9	Antimicrobial treatment of chronic osteomyelitis. ⁵³ ⁶²	Mader JT...Calhoun J	10101310	1999
10	Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. ⁵³ ⁶²	Ryden C...Oldberg A	9581562	1997
11	The effect of growth temperature on Staphylococcus aureus binding to type I collagen. ⁵³ ⁶²	Clark BA...Best GK	7715422	1994
12	A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. ⁵³ ⁶²	Switalski LM...Hook M	8382334	1993
13	Radiologic finding of intraosseous gas: A rare case of emphysematous osteomyelitis of the foot. ⁶²	Bhattarai V...Poudel ASK	36471739	2023
14	Image-guided percutaneous bone biopsy for pediatric osteomyelitis: correlating MRI findings, tissue pathology and culture, and effect on clinical management. ⁶²	Yen C...Desai SB	35882659	2023
15	Management of bone diseases: looking at scaffold-based strategies for drug delivery. ⁶²	Bordone M...Bettencourt A	35816230	2023
16	Hybrid imaging of Diabetic Foot Infections. ⁶²	Abikhzer G...Israel O	36089528	2023
17	PET-Computed Tomography in Bone and Joint Infections. ⁶²	Loharkar S...Basu S	36442966	2023
18	D-dimer may aid in the diagnosis of pediatric musculoskeletal infections: a prospective study. ⁶²	Topak D...Bilal O	35703242	2023
19	First recorded outbreak of Veronaea botryosa in North American amphibians: Clinicopathologic features of a rare cause of phaeohyphomycosis in captive White's tree frogs (Litoria caerulea). ⁶²	Mayer T...Fagre AC	36193194	2022
20	Synergistic Antibacterial Effect and Mechanism of Allicin and an Enterobacter cloacae Bacteriophage. ⁶²	Tao Z...Wang R	36472428	2022
21	Unstable Ankle Fractures in Neuropathic Diabetics. ⁶²	Pinzur MS	36107123	2022
22	A European survey on post-mortem inspection of finishing pigs: Total condemnation criteria to declare meat unfit for human consumption. ⁶²	Vieira-Pinto M...Laukkanen-Ninios R	35932591	2022
23	A Novel Technique of Robotic-Assisted Simple Cystectomy During Urinary Diversion for Benign Indications. ⁶²	Makedon AM...Lloyd GL	36462582	2022
24	Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions. ⁶²	Heng BC...Deng X	36453574	2022
25	Comparison of the clinical outcomes between vascularized bone graft and the Masquelet technique for the reconstruction of Gustilo type III open tibial fractures. ⁶²	Lan CY...Yu YH	36451238	2022
26	Isolation of Lactococcus garvieae NEP21 from raw cow (Bos indicus) milk in Nepal. ⁶²	Dawadi P...Bhatt LR	36470377	2022
27	Management patterns and outcomes of patients hospitalized with diabetic foot ulcers at one tertiary care hospital. ⁶²	Bhasin A...Galvin S	36474123	2022
28	A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection. ⁶²	Kitano D...Sakakibara S	36382133	2022
29	Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients. ⁶²	Pham TT...Swiss Transplant Cohort Study	36031963	2022
30	Plantar Skin Defect Reconstruction: A Large Series With a 15-Year Follow-up. ⁶²	Nazerani S...Keramati MR	33393408	2022
31	Management of Seymour Fractures in Children and Adolescents: A Systematic Review and Meta-Analysis. ⁶²	Kiely AL...Cooper LRL	34810026	2022
32	Intensive Glycemic Control for Diabetic Foot Ulcer Healing: A Multicentric, Randomized, Parallel Arm, Single-Blind, Controlled Study Protocol (INGLOBE Study). ⁶²	Rastogi A...Bal A	32907433	2022
33	Preventing osteolytic lesions and osteomyelitis in multiple myeloma. ⁶²	Dao A...Schindeler A	36388641	2022
34	The dark satanic mills: Evaluating patterns of health in England during the industrial revolution. ⁶²	Buckberry J...Crane-Kramer G	36335796	2022
35	Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component. ⁶²	Bhakta P...Lyapichev KA	35802244	2022
36	Two phenotypes of chronic recurrent multifocal osteomyelitis with different patterns of bone involvement. ⁶²	Cebecauerova D...Horvath R	36456962	2022
37	Review on skeletal disorders caused by Staphylococcus spp. in poultry. ⁶²	Szafraniec GM...Dolka B	35076352	2022
38	Distally Based Peroneal Artery Perforator-Plus Fasciocutaneous Flap to Reconstruct Soft Tissue Defect Combined With Chronic Osteomyelitis in the Lateral Malleolus. ⁶²	Luo Z...Lv G	32912022	2022
39	Squamous cell carcinoma complicating chronic osteomyelitis: A systematic review and case series. ⁶²	Corrigan RA...McNally M	34969605	2022
40	Four cases of abdominal expander implantation in adult chronic osteomyelitis of lower extremity with soft tissue defect and literature review. ⁶²	Zhang X...Zhao Z	35302286	2022
41	Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw. ⁶²	Minami Y...Ogura I	36345763	2022
42	Local Antibiotic Delivery Systems in the Surgical Treatment of Diabetic Foot Osteomyelitis: Again, No Benefit? ⁶²	Chatzipapas C...Papanas N	33295248	2022
43	Escalation of antimicrobial resistance among MRSA part 2: focus on infections and treatment. ⁶²	Lynch JP...Zhanel GG	36469648	2022
44	[Clinical characteristics of 18 children with chronic nonbacterial osteomyelitis]. ⁶²	Liu HM...Sun L	36444429	2022
45	Kingella kingae Osteomyelitis Should be Ruled out in Pediatric Langerhans Cell Histiocytosis. ⁶²	Yagupsky P	36102720	2022
46	Emphysematous osteomyelitis of the spine mimicking esophageal rupture. ⁶²	Mizumoto J	35905773	2022
47	Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review. ⁶²	Macias D...Rizk HG	36351221	2022
48	Sacral Insufficiency Fractures After Total Pubectomy for Osteomyelitis: A Case Series. ⁶²	Vasdev R...Elliott SP	36115424	2022
49	Prospective Validation of the Value of Adding Osteomyelitis to Moderate and Severe Categories of Diabetic Foot Infections. ⁶²	Aragon-Sanchez J...Rojas-Bonilla JM	35924359	2022
50	Diagnostic performance of quantitative Ga-SPECT/CT for patients with lower-limb osteomyelitis. ⁶²	Nishikawa Y...Kumita S	36450868	2022

Sources

Genes for Osteomyelitis

Genes related to Osteomyelitis (0 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	LPIN2	Lipin 2	Protein Coding	24.06	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	23	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
3	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	21.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11792597
4	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	19.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11865431 11139207 19880337
5	TNFSF11	TNF Superfamily Member 11	Protein Coding	16.7	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17032395
6	CTSK	Cathepsin K	Protein Coding	16.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17032395
7	BMP2	Bone Morphogenetic Protein 2	Protein Coding	15.88	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17233287
8	CRP	C-Reactive Protein	Protein Coding	15.77	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	15.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15872059
10	IL1B	Interleukin 1 Beta	Protein Coding	15.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	TNF	Tumor Necrosis Factor	Protein Coding	14.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	IL6	Interleukin 6	Protein Coding	14.68	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	IL10	Interleukin 10	Protein Coding	14.15	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	IFNG	Interferon Gamma	Protein Coding	14.14	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	IL1A	Interleukin 1 Alpha	Protein Coding	14.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	FBLIM1	Filamin Binding LIM Protein 1	Protein Coding	13.96	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	13.69	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	TLR2	Toll Like Receptor 2	Protein Coding	13.4	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	13.36	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	CASP1	Caspase 1	Protein Coding	13.31	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	IL4	Interleukin 4	Protein Coding	13.27	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	13.15	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	13.11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	TLR4	Toll Like Receptor 4	Protein Coding	13.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	CSF3	Colony Stimulating Factor 3	Protein Coding	13.01	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
26	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	12.97	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
27	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	12.93	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
28	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	12.7	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
29	ALPL	Alkaline Phosphatase, Biomineralization Associated	Protein Coding	12.68	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	12.53	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
31	PYCARD	PYD And CARD Domain Containing	Protein Coding	12.43	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
32	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	12.42	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
33	MMP1	Matrix Metallopeptidase 1	Protein Coding	12.36	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
34	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	12.36	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
35	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	12.34	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Osteomyelitis

Sources

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Sources

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 87)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.97	CASP1 CRP CTSK CXCL8 IFNG IFNGR1
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.88	BMP2 CXCL8 FBLIM1 IL10 IL1A IL1B
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.72	BMP2 CASP1 CXCL8 IFNG IL10 IL1A
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.61	BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
5	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.54	TNF TLR2 PPP3CA IL6 IL1B IL1A
6	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.5	BMP2 CXCL8 IL10 IL1A IL1B IL6
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.41	TNFSF11 TNF IL6 IL1B IL1A IL10
8	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.4	TNFSF11 TNF IL6 IL1RN IL1B IL1A
9	ADORA2B mediated anti-inflammatory cytokines production ⁶⁶ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ Androgen receptor signaling pathway ⁷⁴ Anti-inflammatory response favouring Leishmania parasite infection ⁶⁶ Beta-agonist/Beta-blocker Pathway, Pharmacodynamics ⁶⁰ CD163 mediating an anti-inflammatory response ⁶⁶ Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation ²² G alpha (z) signalling events ⁶⁶ G protein signaling pathways ⁷⁴ Glucagon signaling in metabolic regulation ⁶⁶ GPER1 signaling ⁶⁶ Hedgehog Signaling in Mammals ⁶⁴ Leishmania infection ⁶⁶ Leishmania parasite growth and survival ⁶⁶ LTC4-CYSLTR mediated IL4 production ⁶⁶ Relaxin Pathway ⁶⁴ Signal transduction cAMP signaling ²²	13.35	PPP3CA NLRP3 IL6 IL1B IL1A IL10
10	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.93	TNF TLR2 IL6 IL1B IL1A CXCL8
11	Alzheimer's disease and miRNA effects ⁷⁴ Show member pathways Alzheimer's disease ⁷⁴	12.88	TNF PPP3CA IL6 IL1B IL1A
12	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.81	TNF TLR2 IL6 IL1B IL1A BMP2
13	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ TNFs bind their physiological receptors ⁶⁶ TRAF Pathway ⁶⁴	12.77	TNFSF11 TNF TLR2 PPP3CA IL1B IL1A
14	Malignant pleural mesothelioma ⁷⁴	12.76	NLRP3 IL6 IL1B IL10 CASP1
15	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.75	BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
16	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.74	TNF IL1B IL1A IFNGR1 IFNG
17	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.73	TNF TLR2 PPP3CA IL6 IL1RN IL1B
18	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.66	IFNG IL10 IL1B IL6 TNF
19	NF-kappaB Signaling ³	12.66	TNFSF11 TNF TLR2 PPP3CA IL1RN IL1B
20	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.65	TNF TLR2 NLRP3 IL6 IL1B CXCL8
21	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.46	TNF IL6 IL1B IL1A IFNGR1 IFNG
22	MAPK signaling pathway ⁷⁴	12.45	TNF PPP3CA IL1B IL1A
23	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.34	TNF TLR2 IL6 CXCL8
24	Colorectal Cancer Metastasis ⁶⁴	12.31	TNF TLR2 IL6 IFNGR1 IFNG
25	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.27	TNF IL6 IL1RN IL1B IL1A IL10
26	Neuroinflammation and glutamatergic signaling ⁷⁴	12.18	TNF IL6 IL1B IL1A IL10 IFNGR1
27	Adipogenesis ⁷⁴	12.15	TNF LPIN2 IL6 BMP2
28	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12.12	TNF IL6 IL1B IL1A IL10 CXCL8
29	Senescence and autophagy in cancer ⁷⁴	12.1	IL6 IL1B IL1A IFNG CXCL8 BMP2
30	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.09	TNF IL6 IL10 IFNG
31	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.05	TNF TLR2 IL6 IL1RN IL1B IL1A
32	Inflammasomes ⁶⁶ Show member pathways Cell recruitment (pro-inflammatory response) ⁶⁶ Influenza A virus infection ⁷⁴ Interleukin-1 processing ⁶⁶ Purinergic signaling in leishmaniasis infection ⁶⁶ The AIM2 inflammasome ⁶⁶ The NLRP1 inflammasome ⁶⁶ The NLRP3 inflammasome ⁶⁶	12.04	NLRP3 IL1B IL1A CASP1
33	Spinal cord injury ⁷⁴	12.04	TNF PPP3CA IL6 IL1B IL1A IFNG
34	Allograft rejection ⁷⁴	12.01	TNF IL1B IL1A IL10 IFNG CXCL8
35	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.98	TLR2 IL6 IL1B IFNG
36	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.96	IFNG IFNGR1 IL1B NLRP3 TNF
37	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.92	TNF IL6 IL1B IL10 IFNG
38	Innate Lymphoid Cells Differentiation ⁶⁵	11.91	TNF IL1B IL10 IFNG
39	Clock-controlled autophagy in bone metabolism ⁷⁴	11.91	TNFSF11 IL6 CTSK BMP2
40	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.91	TNF TLR2 IL6 IL1B IL10 IFNGR1
41	Interferon Pathway ⁶⁴	11.9	IL6 IFNGR1 IFNG
42	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.9	TNF IL6 IL10 IFNG CRP
43	Burn wound healing ⁷⁴	11.88	TNF IL6 IL1B CXCL8
44	Th17 cell differentiation pathway ⁷⁴	11.88	PPP3CA IL6 IL1B IFNGR1 IFNG
45	AP-1 transcription factor network ⁶¹	11.84	IL6 IL10 IFNG CXCL8
46	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.82	IL6 CXCL8 CRP
47	Glucocorticoid receptor regulatory network ⁶¹	11.82	IL6 IFNG CXCL8
48	miRNAs involvement in the immune response in sepsis ⁷⁴	11.82	TNF IL6 IL1A IL10 CXCL8
49	Acute viral myocarditis ⁷⁴	11.81	IL6 IL10 IFNG
50	Lung fibrosis ⁷⁴	11.8	TNF IL6 IL1B CXCL8

Sources

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.03	TNFSF11 TNF NLRP3 IL6 IL1RN IL1B
2	extracellular space	GO:0005615	9.7	BMP2 CRP CTSK CXCL8 IFNG IL10

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.63	BMP2 IL10 IL1A IL1B IL6 LPIN2
2	signal transduction	GO:0007165	10.61	CASP1 CXCL8 IFNG IFNGR1 IL10 IL1B
3	apoptotic process	GO:0006915	10.49	TNF TLR2 NLRP3 IL1B IL1A IFNG
4	negative regulation of cell population proliferation	GO:0008285	10.43	BMP2 CXCL8 IL10 IL1A IL1B IL6
5	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	10.38	CASP1 IL1A IL1B TNF TNFSF11
6	defense response to virus	GO:0051607	10.36	CASP1 IFNG IL6 NLRP3 TLR2
7	cytokine-mediated signaling pathway	GO:0019221	10.35	TNFSF11 IL6 IL1B IL1A IFNGR1
8	positive regulation of JNK cascade	GO:0046330	10.3	TNFSF11 TNF IL1B IL1A
9	positive regulation of tumor necrosis factor production	GO:0032760	10.3	IFNG IFNGR1 IL1A IL6 TLR2
10	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.27	TNFSF11 TNF TLR2 NLRP3 IL6 IL1B
11	positive regulation of interleukin-8 production	GO:0032757	10.25	IL1B IL6 TLR2 TNF
12	response to glucocorticoid	GO:0051384	10.24	TNF IL6 IL1RN IL10
13	calcium-mediated signaling	GO:0019722	10.23	TNFSF11 TNF PPP3CA CXCL8
14	regulation of insulin secretion	GO:0050796	10.23	IFNG IL1B IL6 TNF
15	cellular response to virus	GO:0098586	10.22	NLRP3 IL6 IFNGR1 IFNG
16	positive regulation of inflammatory response	GO:0050729	10.22	TNF TLR2 NLRP3 IL1B IFNG CASP1
17	positive regulation of interleukin-1 beta production	GO:0032731	10.21	TNF NLRP3 IL6 IFNG CASP1
18	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.2	TNF IL1B IFNG
19	osteoclast differentiation	GO:0030316	10.2	TNFSF11 TNF BMP2
20	positive regulation of cytokine production	GO:0001819	10.2	TNF IL1B IL1A IL10 IFNG
21	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.19	IL1B TLR2 TNF
22	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	10.19	TNF IL1B IL1A
23	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.19	TNF IL6 IL10
24	positive regulation of mitotic nuclear division	GO:0045840	10.18	TNF IL1B IL1A
25	liver regeneration	GO:0097421	10.18	TNF IL6 IL10
26	microglial cell activation	GO:0001774	10.18	TNF TLR2 IFNGR1 IFNG
27	positive regulation of interleukin-6 production	GO:0032755	10.18	TNF TLR2 IL6 IL1B IL1A IFNG
28	defense response to Gram-positive bacterium	GO:0050830	10.18	ACP5 CRP IL1B IL6 NLRP3 TLR2
29	positive regulation of vascular endothelial growth factor production	GO:0010575	10.17	IL6 IL1B IL1A
30	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.17	TNFSF11 TNF PPP3CA IL6 IL1B IL10
31	negative regulation of neurogenesis	GO:0050768	10.16	TNF IL6 IL1B
32	bone resorption	GO:0045453	10.16	TNFSF11 CTSK ACP5
33	inflammatory response	GO:0006954	10.16	TNF TLR2 NLRP3 IL6 IL1RN IL1B
34	positive regulation of amyloid-beta formation	GO:1902004	10.14	TNF IFNGR1 IFNG
35	response to lipopolysaccharide	GO:0032496	10.14	TNF TLR2 IL1B IL1A IL10 ACP5
36	positive regulation of glial cell proliferation	GO:0060252	10.13	TNF IL6 IL1B
37	positive regulation of osteoclast differentiation	GO:0045672	10.13	IFNG PPP3CA TNF TNFSF11
38	cellular response to lipopolysaccharide	GO:0071222	10.13	CASP1 CXCL8 IL10 IL1A IL1B IL6
39	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	10.12	TNF IL1B IFNG
40	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10.11	TNF IL1B IL10
41	negative regulation of amyloid-beta clearance	GO:1900222	10.09	TNF IFNGR1 IFNG
42	positive regulation of neuroinflammatory response	GO:0150078	10.09	TNF IL6 IL1B
43	positive regulation of chemokine production	GO:0032722	10.09	TNF TLR2 IL6 IL1B IFNG
44	negative regulation of lipid storage	GO:0010888	10.08	TNF IL6 CRP
45	vascular endothelial growth factor production	GO:0010573	10.07	TNF IL6 IL1B
46	astrocyte activation	GO:0048143	10.06	IFNG IFNGR1 IL1B TNF
47	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	10.03	IL6 IL1RN
48	positive regulation of immature T cell proliferation in thymus	GO:0033092	10.03	IL1B IL1A
49	negative regulation of cytokine production involved in immune response	GO:0002719	10.02	TNF IL10
50	positive regulation of fever generation	GO:0031622	10.02	TNF IL1B