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MCID: OST017
MIFTS: 63

Osteomyelitis

Categories: Rare diseases, Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Osteomyelitis

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MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 76 53 29 55 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Osteomyelitis

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NIH Rare Diseases : 53 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to chronic recurrent multifocal osteomyelitis and mycobacterium fortuitum, and has symptoms including pain in limb and bone pain. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ciprofloxacin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include bone or, bone and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 76 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

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Related Diseases for Osteomyelitis

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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 541)
# Related Disease Score Top Affiliating Genes
1 chronic recurrent multifocal osteomyelitis 33.2 CASP1 FBLIM1 IL1B LPIN2
2 mycobacterium fortuitum 32.8 CXCL8 IFNGR1
3 toxic shock syndrome 30.9 CXCL8 IFNG IL1B IL6 TNF
4 chronic granulomatous disease 30.6 IFNG IL1B TNF
5 q fever 30.6 IFNG IL1B TNF
6 melioidosis 30.5 IFNG IL6 TNF
7 interferon gamma, receptor 1, deficiency 30.4 IFNG IFNGR1
8 paracoccidioidomycosis 30.2 IFNG IL6 TNF
9 extrapulmonary tuberculosis 30.1 IFNG IL1B IL1RN
10 endocarditis 30.1 CXCL8 IL6 TNF
11 esophagitis 30.0 CXCL8 IL1B IL6
12 pneumonia 30.0 CXCL8 IL1B IL6 TNF
13 acute transverse myelitis 29.9 CXCL8 IL6
14 spondylitis 29.8 IL1RN IL6 TNF
15 pyelonephritis 29.8 CXCL8 IL1B IL6 TNF
16 reactive arthritis 29.8 IFNG IL6 TNF
17 haemophilus influenzae 29.8 CXCL8 IL1B TNF
18 transverse myelitis 29.7 CXCL8 IL6 TNF
19 prostatitis 29.7 CXCL8 IL1B IL6 TNF
20 conjunctivitis 29.7 CXCL8 IFNG IL6
21 otitis media 29.7 CXCL8 IL1B IL6 TNF
22 fasciitis 29.7 CXCL8 IL6 TNF
23 adult-onset still's disease 29.7 IL1B IL1RN IL6 TNF
24 ulcerative colitis 29.6 CXCL8 IL1B IL6 TNF
25 meningitis 29.6 CXCL8 IFNG IL1B IL6 TNF
26 appendicitis 29.6 CXCL8 IL1B IL6 TNF
27 acquired immunodeficiency syndrome 29.5 IFNG IL1B IL6 TNF
28 bacterial meningitis 29.3 CXCL8 IL1B IL6 TNF
29 peritonitis 29.3 CXCL8 IL1B IL6 TNF
30 osteonecrosis 29.3 ACP5 BMP2 TNFSF11
31 lymphadenitis 29.3 CXCL8 IFNG IFNGR1 IL1B TNF
32 wegener granulomatosis 29.2 CXCL8 IFNG IL6 TNF
33 colitis 29.2 CXCL8 IFNG IL1B IL6 TNF
34 familial mediterranean fever 29.2 CASP1 IL1B IL1RN TNF
35 synovitis 29.1 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
36 autoimmune disease 29.1 IFNG IL1B IL1RN IL6 TNF
37 myeloma, multiple 29.0 CXCL8 IL6 TNF TNFSF11
38 brucellosis 29.0 CXCL8 IFNG IL1RN IL6 TNF
39 joint disorders 28.9 IL1B IL1RN IL6 TNF TNFSF11
40 gingivitis 28.7 CXCL8 IL1A IL1B IL6 TNF
41 diabetes mellitus 28.5 IFNG IL1A IL1B IL1RN IL6 TNF
42 psoriasis 28.5 CXCL8 IFNG IL1A IL1B IL6 TNF
43 arthritis 28.4 CXCL8 IFNG IL1A IL1B IL1RN IL6
44 typhoid fever 28.2 CASP1 IFNG IFNGR1 IL1B IL6 TNF
45 inflammatory bowel disease 26.6 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
46 rheumatoid arthritis 25.5 ACP5 CTSK CXCL8 IFNG IL1A IL1B
47 osteoporosis 25.4 ACP5 BMP2 CTSK IFNG IL1A IL1B
48 osteomyelitis, sterile multifocal, with periostitis and pustulosis 12.2
49 orbital osteomyelitis 12.1
50 majeed syndrome 12.0

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis
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Symptoms & Phenotypes for Osteomyelitis

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UMLS symptoms related to Osteomyelitis:


pain in limb, bone pain

MGI Mouse Phenotypes related to Osteomyelitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 IL6 IL1A IL1B LPIN2 PPP3CA IL1RN
2 hematopoietic system MP:0005397 10.3 TNF IL6 IL1A IL1B LPIN2 PPP3CA
3 immune system MP:0005387 10.25 IL6 IL1A IL1B LPIN2 PPP3CA IL1RN
4 cardiovascular system MP:0005385 10.21 IL1RN IL6 IL1A LPIN2 IL1B TNF
5 cellular MP:0005384 10.19 IL1RN IFNGR1 IL6 TNF CASP1 CTSK
6 mortality/aging MP:0010768 10.1 IL1RN SPTLC1 IFNGR1 IL6 LPIN2 IL1B
7 digestive/alimentary MP:0005381 10.02 IFNGR1 IL6 TNF CTSK BMP2 IFNG
8 integument MP:0010771 10.02 IL6 IL1A IL1B IL1RN TNF TNFSF11
9 nervous system MP:0003631 9.9 SPTLC1 IL6 LPIN2 IL1B PPP3CA TNF
10 neoplasm MP:0002006 9.86 IL6 IL1A IL1B TNF TNFSF11 IFNG
11 reproductive system MP:0005389 9.7 SPTLC1 IL6 LPIN2 IL1RN TNF TNFSF11
12 skeleton MP:0005390 9.32 IL6 IL1B IL1RN TNF TNFSF11 IFNGR1
Sources

Drugs & Therapeutics for Osteomyelitis

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Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 258)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 85721-33-1 2764
2
Sulfamethoxazole Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 738-70-5 5578
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
5
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 1404-90-6 441141 14969
6
Cefepime Approved, Investigational Phase 4,Phase 2,Early Phase 1 88040-23-7 5479537
7
Cefotaxime Approved Phase 4,Early Phase 1 63527-52-6 456256 5742673
8
Cefoxitin Approved Phase 4,Early Phase 1 35607-66-0 441199
9
Ceftriaxone Approved Phase 4,Early Phase 1 73384-59-5 5479530 5361919
10
Doxycycline Approved, Investigational, Vet_approved Phase 4,Early Phase 1 564-25-0 54671203
11
Fusidic Acid Approved, Investigational Phase 4,Phase 2,Phase 3 6990-06-3 3000226
12
Levofloxacin Approved, Investigational Phase 4,Early Phase 1 100986-85-4 149096
13
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 165800-03-3 441401
14
Ofloxacin Approved Phase 4,Early Phase 1 82419-36-1 4583
15
Rifampicin Approved Phase 4,Early Phase 1 13292-46-1 5458213 5381226
16
Dalbavancin Approved, Investigational Phase 4,Phase 3,Phase 2 91097-81-3, 171500-79-1 122186
17
Nafcillin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 985-16-0, 147-52-4 8982
18
Teicoplanin Approved, Investigational Phase 4,Phase 3,Phase 2 61036-62-2
19
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 18323-44-9 29029
20
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 59-30-3 6037
22
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 58-05-9 143 6006
23
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
24 Gentamicins Phase 4,Early Phase 1
25 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Antimalarials Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
29 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
30 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
31 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable,Early Phase 1
32 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
33 Folic Acid Antagonists Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
34 Renal Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
35 Topoisomerase Inhibitors Phase 4,Phase 2,Not Applicable,Early Phase 1
36 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
37 Vitamin B Complex Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
38 Antibodies Phase 4,Phase 3,Phase 2
39 Immunoglobulins Phase 4,Phase 3,Phase 2
40 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
41 Micronutrients Phase 4,Phase 1
42 Trace Elements Phase 4,Phase 1
43 methicillin Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
44 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
45 Cytochrome P-450 CYP3A Inducers Phase 4,Early Phase 1
46 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Early Phase 1
47 gamma-Globulins Phase 4,Phase 3,Phase 2
48 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
49 Clindamycin palmitate Phase 4,Phase 2,Phase 3,Early Phase 1
50 Clindamycin phosphate Phase 4,Phase 2,Phase 3,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 134)
# Name Status NCT ID Phase Drugs
1 CERAMENTâ„¢|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
3 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
4 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
5 Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
6 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
7 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
8 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
9 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
10 Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures Enrolling by invitation NCT02400112 Phase 4 Vancomycin
11 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
12 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
13 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
14 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
15 Use of Santyl Within an Accountable Care Organization Withdrawn NCT02716519 Phase 4
16 Platelet Gel in Systemic Sclerosis Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
17 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
18 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
19 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
20 Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers Completed NCT01586481 Phase 3
21 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
22 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
23 Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections Completed NCT00423657 Phase 3 ceftaroline;vancomycin plus aztreonam;Placebo
24 Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections Completed NCT00424190 Phase 3 IV Vancomycin plus IV Aztreonam;Ceftaroline
25 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
26 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
27 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
28 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
29 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
30 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
31 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
32 Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
33 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
34 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
35 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
36 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
37 Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Completed NCT02066402 Phase 3 Tedizolid (BAY119-2631);Placebo Tedizolid (BAY119-2631);Linezolid;Placebo Linezolid
38 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Recruiting NCT03174366 Phase 3 Denosumab
39 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
40 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
41 Study of Octanorm Subcutaneous IG in Patients With PID Recruiting NCT01888484 Phase 3
42 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
43 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
44 Nebulized Epinephrine and Oral Dexamethasone in Bronchiolitis Not yet recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
45 Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections. Terminated NCT02202135 Phase 3 Ceftaroline fosamil;Vancomycin;Aztreonam
46 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
47 Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
48 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
49 Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Subjects With Osteomyelitis Completed NCT02685033 Phase 2 Dalbavancin;Comparator
50 Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Osteomyelitis

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Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 29
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Anatomical Context for Osteomyelitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

19
Bone Or

MalaCards organs/tissues related to Osteomyelitis:

41
Bone, Skin, Testes, Bone Marrow, Spinal Cord, Kidney, Lung
Sources

Publications for Osteomyelitis

About this section

Articles related to Osteomyelitis:

(show top 50) (show all 1516)
# Title Authors Year
1
<i>Mycobacterium kansasii</i> osteomyelitis - a masquerading disease. ( 29568531 )
2018
2
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report. ( 29443819 )
2018
3
The role of whole-body magnetic resonance imaging in diagnosing chronic recurrent multifocal osteomyelitis. ( 29904495 )
2018
4
The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29718410 )
2018
5
The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29596638 )
2018
6
Pyomyositis and osteomyelitis: an unusual cause of abdominal pain. ( 29559487 )
2018
7
Biologic treatment for chronic recurrent multifocal osteomyelitis: report of four cases and review of the literature. ( 29127574 )
2018
8
A severe case of &amp;lt;em&amp;gt;Mycobacterium ulcerans&amp;lt;/em&amp;gt; (Buruli ulcer) osteomyelitis requiring a below-knee amputation. ( 29642809 )
2018
9
Vancomycin incorporated chitosan/gelatin coatings coupled with TiO<sub>2</sub>-SrHAP surface modified cp-titanium for osteomyelitis treatment. ( 29395341 )
2018
10
Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )
2018
11
Optimising diagnostic strategies in emphysematous osteomyelitis. ( 29939336 )
2018
12
Abscess originating from osteomyelitis as a cause of lower urinary tract symptoms (LUTS) and acute urinary retention. ( 29930185 )
2018
13
Chronic recurrent multifocal osteomyelitis in pediatrics: A diagnostic challenge. ( 29776891 )
2018
14
Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. ( 29124297 )
2018
15
Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity. ( 29425755 )
2018
16
Escherichia coli isolates from femoral bone marrow of broilers exhibit diverse pheno- and genotypic characteristics that do not correlate with macroscopic lesions of bacterial chondronecrosis with osteomyelitis (BCO). ( 29451003 )
2018
17
In this issue - July 2018: Recommendations on equine PPIDa88A^a88Prevalence of alphaviruses in horses in North Queenslanda88A^a88Endoscopic transection of uterine tube bands in maresa88A^a88Radiography vs CT in osteomyelitis in foalsa88A^a88Transmission of BVDV to alpacasa88A^a88Dietary pH balance in cows with milk fever. ( 29944748 )
2018
18
Osteomyelitis of the pubic symphysis after transrectal biopsies of the prostate. ( 29935934 )
2018
19
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis. ( 29866071 )
2018
20
Management of Pediatric Acute Hematogenous Osteomyelitis, Part I: Antimicrobial Stewardship Approach and Review of Therapies for Methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes, and Kingella kingae. ( 29920709 )
2018
21
Genome Sequence of Staphylococcus aureus Ex1, Isolated from a Patient with Spinal Osteomyelitis. ( 29954915 )
2018
22
Dynamic contrast-enhanced magnetic resonance imaging for differentiating osteomyelitis from acute neuropathic arthropathy in the complicated diabetic foot. ( 29654348 )
2018
23
Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )
2018
24
Chronic non-suppurative mandibular osteomyelitis with proliferative periostitis: A review. ( 29435520 )
2018
25
Bone inflammation and chronic recurrent multifocal osteomyelitis. ( 29565497 )
2018
26
Update on the genetics of nonbacterial osteomyelitis in humans. ( 29912021 )
2018
27
Chronic Recurrent Multifocal Osteomyelitis of the Mandible: A Diagnostic Challenge. ( 29652766 )
2018
28
Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products. ( 29391581 )
2018
29
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
30
Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical picture and radiography. ( 29844940 )
2018
31
Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis. ( 29403199 )
2018
32
Mandibular Involvement in Recurrent Multifocal Osteomyelitis Associated with SAPHO Syndrome. ( 29387665 )
2018
33
Cranial Osteomyelitis: The Old Enemy Is Back. ( 29958369 )
2018
34
Campylobacter jejuni vertebral osteomyelitis or tuberculosis: persisting diagnostic ambiguity - Authors' reply. ( 29412960 )
2018
35
Beyond ulcers and osteomyelitis: imaging of less common musculoskeletal complications in diabetes mellitus. ( 29419313 )
2018
36
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
37
Lower-Extremity Osteomyelitis Treatment Using Calcium Sulfate/Hydroxyapatite Bone Void Filler with Antibiotics <sub>Seven-Year Retrospective Study</sub>. ( 29932757 )
2018
38
Comparison of conventional radiography and computed tomography as aids in the diagnosis of osteomyelitis in 11 foals. ( 29944745 )
2018
39
Chronic recurrent multifocal osteomyelitis: a case report. ( 29454377 )
2018
40
COULD OZONE TREATMENT BE A PROMISING ALTERNATIVE FOR OSTEOMYELITIS? AN EXPERIMENTAL STUDY. ( 29977149 )
2018
41
Medication-related osteonecrosis of the jaw, osteoradionecrosis, and osteomyelitis: A comparative histopathological study. ( 29723337 )
2018
42
A case of chronic granulomatous craniofacial osteomyelitis. ( 29942784 )
2018
43
Serum procollagen type 1 N propeptide: A novel diagnostic test for diabetic foot osteomyelitis - A case-control study. ( 29937901 )
2018
44
Going Bone Deep: Osseous Rosai-Dorfman Disease in an Adult with Recurrent, Culture-Negative Osteomyelitis. ( 29888015 )
2018
45
Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )
2018
46
Osteomyelitis in Cat-Scratch Disease: A Never-Ending Dilemma-A Case Report and Literature Review. ( 29808150 )
2018
47
Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder. ( 29425711 )
2018
48
Combined Labeled Leukocyte and Technicium 99 Sulfur Colloid Bone Marrow Imaging: Differentiating Primary Pyomyositis Pseudotumor from Osteomyelitis and Multiple Bone Infarcts. ( 29772988 )
2018
49
Campylobacter jejuni vertebral osteomyelitis or tuberculosis: persisting diagnostic ambiguity. ( 29412958 )
2018
50
Dalbavancin for treatment of implant-related methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model. ( 29941909 )
2018
Sources

Variations for Osteomyelitis

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Expression for Osteomyelitis

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Search GEO for disease gene expression data for Osteomyelitis.
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Pathways for Osteomyelitis

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Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.08 CASP1 CTSK CXCL8 IFNG IFNGR1 IL1A
2
PEDF Induced Signaling 64
Show member pathways
 13.74 BMP2 CASP1 CXCL8 IFNG IFNGR1 IL1A
3
TGF-Beta Pathway 64
Show member pathways
 13.56 BMP2 CXCL8 IFNG IFNGR1 IL1A IL1B
4
Akt Signaling 64
Show member pathways
 13.44 BMP2 CXCL8 IL1A IL1B IL6 TNF
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.43 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
6
PAK Pathway 64
Show member pathways
 13.36 BMP2 CASP1 CXCL8 IL1A IL1B IL6
7
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.11 CASP1 CTSK CXCL8 IFNG IFNGR1 IL1B
8
Allograft rejection 1 37
Show member pathways
 12.97 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
9
Pathways in cancer 37
12.87 BMP2 CXCL8 IFNG IFNGR1 IL6
10
IL-2 Pathway 64
Show member pathways
 12.87 IFNG IFNGR1 IL1A IL1B PPP3CA TNF
11
Influenza A 37
Show member pathways
 12.86 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
12
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.85 CASP1 CXCL8 IFNG IL1B IL6 TNF
13
MAPK signaling pathway 1 37
12.81 CASP1 IL1A IL1B PPP3CA TNF
14
NF-KappaB Family Pathway 64
Show member pathways
 12.76 BMP2 IL1A IL1B IL6 TNF
15
4-1BB Pathway 64
Show member pathways
 12.72 IFNG IFNGR1 IL1A IL1B TNF
16
Regulation of IFNA signaling 66
Show member pathways
 12.72 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
17
NF-kappaB Signaling 4
12.66 IFNG IL1B IL1RN PPP3CA TNF TNFSF11
18
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.64 CXCL8 IFNGR1 IL6 PPP3CA TNF
19
TRAF Pathway 64
Show member pathways
 12.61 CASP1 IL1A IL1B PPP3CA TNF TNFSF11
20
T cell receptor signaling pathway 37
Show member pathways
 12.55 IFNG IL1A IL1B IL6 PPP3CA TNF
21
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.53 IFNG IFNGR1 PPP3CA TNF
22
Th17 cell differentiation 37
Show member pathways
 12.51 IFNG IFNGR1 IL1A IL1B IL6 PPP3CA
23
RANK Signaling in Osteoclasts 64
Show member pathways
 12.45 ACP5 CTSK PPP3CA TNFSF11
24
IL-17 Family Signaling Pathways 65
Show member pathways
 12.42 CXCL8 IFNG IL1B IL6 TNF
25
Folate Metabolism 1
Show member pathways
 12.38 IFNG IL1B IL6 TNF
26
IL-1 signaling pathway 1
Show member pathways
 12.35 CASP1 IL1A IL1B IL1RN
27
Th1 Differentiation Pathway 65
Show member pathways
 12.35 IFNG IFNGR1 IL1B IL6 TNF
28
Toxoplasmosis 37
Show member pathways
 12.35 IFNG IFNGR1 IL1A IL1B TNF
29
IL-1 Family Signaling Pathways 65
Show member pathways
 12.33 CXCL8 IL1A IL1B IL1RN IL6 TNF
30
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.32 CXCL8 IL1A IL6 TNF
31
Necroptosis 37
Show member pathways
 12.32 CASP1 IFNG IFNGR1 IL1A IL1B TNF
32
C-type lectin receptor signaling pathway 37
Show member pathways
 12.31 CASP1 IL1B IL6 PPP3CA TNF
33
Toll Comparative Pathway 64
Show member pathways
 12.3 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
34
Bacterial infections in CF airways 22
Show member pathways
 12.29 CXCL8 IFNG IFNGR1 IL1B IL6 TNF
35
Tuberculosis 37
12.29 IFNG IFNGR1 IL1A IL1B IL6 PPP3CA
36
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.27 CXCL8 IL1A IL1B IL1RN IL6 TNF
37
Colorectal Cancer Metastasis 64
12.25 IFNG IFNGR1 IL6 TNF
38
Cellular senescence (KEGG) 37
12.23 CXCL8 IL1A IL6 PPP3CA
39
Fluid shear stress and atherosclerosis 37
12.16 IFNG IL1A IL1B TNF
40
Adipogenesis 1
12.14 BMP2 IL6 LPIN2 TNF
41
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.14 BMP2 CASP1 CXCL8 IFNG IFNGR1 IL1A
42
Interleukin-4 and 13 signaling 66
12.11 CXCL8 IL1A IL1B IL6 TNF
43
AGE-RAGE signaling pathway in diabetic complications 37
12.03 CXCL8 IL1A IL1B IL6 TNF
44
Amoebiasis 37
12.01 CXCL8 IFNG IL1B IL6 TNF
45
Senescence and Autophagy in Cancer 1
12.01 BMP2 CXCL8 IFNG IL1A IL1B IL6
46
Hematopoietic cell lineage 37
11.99 IL1A IL1B IL6 TNF
47
Spinal Cord Injury 1
11.99 CXCL8 IFNG IL1A IL1B IL6 PPP3CA
48
NF-kappa B signaling pathway 37
11.98 CXCL8 IL1B TNF TNFSF11
49
TNF signaling pathway 37
11.97 IL1B IL6 TNF
50
HIF-1 signaling pathway 37
11.93 IFNG IFNGR1 IL6
Sources

GO Terms for Osteomyelitis

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Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BMP2 CASP1 CTSK CXCL8 IFNG IL1A
2 extracellular space GO:0005615 9.32 BMP2 CTSK CXCL8 IFNG IL1A IL1B

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 BMP2 IFNG PPP3CA TNF
2 inflammatory response GO:0006954 9.95 BMP2 CXCL8 IL1A IL1B IL1RN IL6
3 response to lipopolysaccharide GO:0032496 9.94 ACP5 CASP1 CXCL8 IL1B
4 positive regulation of protein phosphorylation GO:0001934 9.92 BMP2 IFNG IL1B TNF
5 positive regulation of gene expression GO:0010628 9.91 BMP2 IFNG IL1A IL1B IL6 PPP3CA
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 TNF TNFSF11
7 cellular response to lipopolysaccharide GO:0071222 9.88 CASP1 CXCL8 IL6 TNF
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.88 CASP1 IL1A IL1B TNF TNFSF11
9 defense response to Gram-positive bacterium GO:0050830 9.87 ACP5 IL6 TNF
10 interleukin-1-mediated signaling pathway GO:0070498 9.87 IL1A IL1B IL1RN
11 cellular response to organic cyclic compound GO:0071407 9.85 BMP2 IL1B TNF
12 regulation of insulin secretion GO:0050796 9.84 IFNG IL1B TNF
13 response to glucocorticoid GO:0051384 9.83 IL1RN IL6 TNF
14 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 IL1B IL6 PPP3CA TNF TNFSF11
15 humoral immune response GO:0006959 9.81 IFNG IL6 TNF
16 calcium-mediated signaling GO:0019722 9.81 CXCL8 PPP3CA TNFSF11
17 positive regulation of JNK cascade GO:0046330 9.8 IL1A IL1B TNF TNFSF11
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IFNG IL1B TNF
19 positive regulation of interleukin-6 production GO:0032755 9.76 IL1A IL1B IL6 TNF
20 immune response GO:0006955 9.76 CXCL8 IFNG IL1A IL1B IL1RN IL6
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.75 IL1A IL1B TNF
22 positive regulation of cytokine secretion GO:0050715 9.74 CASP1 IL1A TNF
23 bone resorption GO:0045453 9.72 ACP5 CTSK TNFSF11
24 positive regulation of osteoclast differentiation GO:0045672 9.71 IFNG TNF TNFSF11
25 regulation of osteoclast differentiation GO:0045670 9.7 TNF TNFSF11
26 positive regulation of calcineurin-NFAT signaling cascade GO:0070886 9.69 PPP3CA TNF
27 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.69 IFNG IFNGR1
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IFNG IL1B TNF
29 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 IL1A IL1B
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
31 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.68 IL1A IL1B
32 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
33 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
34 ectopic germ cell programmed cell death GO:0035234 9.65 IL1A IL1B
35 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
36 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
37 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL1RN IL6
38 interleukin-1 beta production GO:0032611 9.61 CASP1 IL1B
39 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
40 regulation of signaling receptor activity GO:0010469 9.61 BMP2 CXCL8 IFNG IL1A IL1B IL1RN
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 IFNG TNF
42 fever generation GO:0001660 9.5 IL1A IL1B IL1RN
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG IL1B TNF
44 cytokine-mediated signaling pathway GO:0019221 9.28 CASP1 CXCL8 IFNGR1 IL1A IL1B IL1RN
45 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 BMP2 IL1A IL1B IL6 LPIN2 PPP3CA
46 negative regulation of cell proliferation GO:0008285 10.04 BMP2 CXCL8 IL1A IL1B IL6

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 BMP2 CXCL8 IFNG IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
Sources

Sources for Osteomyelitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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