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MCID: OST017
MIFTS: 65

Osteomyelitis

Categories: Bone diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Osteomyelitis

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MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 77 54 30 56 45 15 17 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1019
ICD9CM 36 730.1 730.10
MeSH 45 D010019
SNOMED-CT 69 40970001
ICD10 34 M86 M86.9
Sources

Summaries for Osteomyelitis

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NIH Rare Diseases : 54 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to chronic recurrent multifocal osteomyelitis and mycobacterium fortuitum, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 77 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Sources

Related Diseases for Osteomyelitis

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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 727)
# Related Disease Score Top Affiliating Genes
1 chronic recurrent multifocal osteomyelitis 34.4 FBLIM1 IL1B LPIN2
2 mycobacterium fortuitum 32.5 CXCL8 IFNGR1
3 toxic shock syndrome 31.4 CXCL8 IFNG IL10 IL1B IL6 TNF
4 osteopetrosis, autosomal dominant 2 31.2 ACP5 CTSK TNFSF11
5 sporotrichosis 30.3 IFNG IL10
6 melioidosis 30.2 IFNG IL10 IL6 TNF
7 spinal cord injury 30.2 CXCL8 IL6 TNF
8 salmonellosis 30.2 IFNG IFNGR1 IL1B
9 familial mediterranean fever 30.1 IL1B IL1RN TNF
10 endocarditis 30.1 CXCL8 IL10 IL6 TNF
11 neuritis 30.1 IFNG IL1B TNF
12 aspergillosis 30.0 IFNG IL10 TNF
13 q fever 30.0 IFNG IL10 IL1B IL6 TNF
14 interferon gamma, receptor 1, deficiency 30.0 IFNG IFNGR1
15 typhoid fever 30.0 IFNG IFNGR1 IL1B IL6 TNF
16 haemophilus influenzae 29.9 CXCL8 IL1B TNF
17 critical limb ischemia 29.9 IL6 TNF
18 necrotizing fasciitis 29.9 CXCL8 IL1RN IL6
19 osteonecrosis 29.9 ACP5 BMP2 TNFSF11
20 rheumatic fever 29.9 IL10 IL6 TNF
21 poliomyelitis 29.9 IFNG IL10 TNF
22 fasciitis 29.8 CXCL8 IL6 TNF
23 acute pyelonephritis 29.8 CXCL8 IL10 IL6
24 acquired immunodeficiency syndrome 29.8 IFNG IL10 IL1B IL6 TNF
25 diabetes mellitus 29.8 IFNG IL1A IL1B IL1RN IL6 TNF
26 pneumonia 29.8 CXCL8 IL10 IL1B IL6 TNF
27 arteries, anomalies of 29.7 IL1B IL6 TNF
28 peripheral nervous system disease 29.7 IL6 SPTLC1 TNF
29 synovitis 29.7 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
30 paracoccidioidomycosis 29.7 IFNG IL10 IL6 TNF
31 kawasaki disease 29.7 IL10 IL6 TNF
32 periodontitis, chronic 29.7 IL1B IL6 TNFSF11
33 myeloma, multiple 29.7 CXCL8 IL6 TNF TNFSF11
34 common variable immunodeficiency 29.7 IFNG IL10 IL6 TNF
35 meningitis 29.6 CXCL8 IFNG IL10 IL1B IL6 TNF
36 reactive arthritis 29.6 IFNG IL10 TNF
37 pericarditis 29.6 IFNG IL1B IL1RN IL6 TNF
38 arthritis 29.6 CXCL8 IFNG IL10 IL1A IL1B IL1RN
39 spondylitis 29.6 IL1RN IL6 TNF
40 acute pancreatitis 29.6 CXCL8 IL10 IL6
41 pyelonephritis 29.5 CXCL8 IL10 IL1B IL6 TNF
42 appendicitis 29.5 CXCL8 IL10 IL1B IL6 TNF
43 human immunodeficiency virus infectious disease 29.5 IFNG IL10 IL6 TNF
44 bacterial sepsis 29.5 CXCL8 IL10 TNF
45 adult-onset still's disease 29.5 IL1B IL1RN IL6 TNF
46 otitis media 29.4 CXCL8 IL10 IL1B IL6 TNF
47 acute transverse myelitis 29.4 CXCL8 IL10 IL6
48 joint disorders 29.4 IL1B IL1RN IL6 TNF TNFSF11
49 pulmonary tuberculosis 29.4 IFNG IFNGR1 IL10 TNF
50 prostatitis 29.4 CXCL8 IL10 IL1B IL6 TNF

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis
Sources

Symptoms & Phenotypes for Osteomyelitis

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UMLS symptoms related to Osteomyelitis:


bone pain, pain in limb

MGI Mouse Phenotypes related to Osteomyelitis:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ANO5 BMP2 CTSK IFNG IFNGR1 IL10
2 hematopoietic system MP:0005397 10.32 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
3 immune system MP:0005387 10.28 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
4 cardiovascular system MP:0005385 10.25 BMP2 IFNG IFNGR1 IL10 IL1A IL1B
5 cellular MP:0005384 10.24 ANO5 BMP2 CTSK FBLIM1 IFNG IFNGR1
6 growth/size/body region MP:0005378 10.24 BMP2 CTSK IFNG IL10 IL1B IL1RN
7 mortality/aging MP:0010768 10.15 BMP2 IFNG IFNGR1 IL10 IL1B IL1RN
8 craniofacial MP:0005382 10.07 BMP2 CTSK IFNG IL10 IL1B TNF
9 integument MP:0010771 10.06 IFNG IFNGR1 IL10 IL1A IL1B IL1RN
10 digestive/alimentary MP:0005381 10.05 BMP2 CTSK IFNG IFNGR1 IL10 IL6
11 nervous system MP:0003631 9.9 BMP2 CTSK IFNG IFNGR1 IL10 IL1B
12 muscle MP:0005369 9.87 ANO5 IFNG IL10 IL6 PPP3CA TNF
13 neoplasm MP:0002006 9.86 IFNG IFNGR1 IL10 IL1A IL1B IL6
14 reproductive system MP:0005389 9.7 ANO5 BMP2 IFNG IFNGR1 IL10 IL1RN
15 skeleton MP:0005390 9.36 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
Sources

Drugs & Therapeutics for Osteomyelitis

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Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 280)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 58-05-9 6006 143
2
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 738-70-5 5578
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 85721-33-1 2764
4
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 723-46-6 5329
5
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 1404-90-6 441141 14969
6
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
7
Rifampicin Approved Phase 4,Early Phase 1 13292-46-1 5381226 5458213
8
Ceftriaxone Approved Phase 4,Early Phase 1 73384-59-5 5479530 5361919
9
Cefotaxime Approved Phase 4,Early Phase 1 63527-52-6 456256 5742673
10
Cefoxitin Approved Phase 4,Early Phase 1 35607-66-0 441199
11
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 165800-03-3 441401
12
Levofloxacin Approved, Investigational Phase 4,Early Phase 1 100986-85-4 149096
13
Doxycycline Approved, Investigational, Vet_approved Phase 4,Early Phase 1 564-25-0 54671203
14
Fusidic Acid Approved, Investigational Phase 4,Phase 2,Phase 3 6990-06-3 3000226
15
Ofloxacin Approved Phase 4,Early Phase 1 82419-36-1 4583
16
Cefepime Approved, Investigational Phase 4,Phase 2,Early Phase 1 88040-23-7 5479537
17
Ceftaroline fosamil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 229016-73-3
18
Dalbavancin Approved, Investigational Phase 4,Phase 3,Phase 2 171500-79-1, 91097-81-3 122186
19
Nafcillin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 985-16-0, 147-52-4 8982
20
Teicoplanin Approved, Investigational Phase 4,Phase 3,Phase 2 61036-62-2
21
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
22
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 18323-44-9 29029
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 59-30-3 6037
24
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
25 Gentamicins Phase 4,Early Phase 1
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Nutrients Phase 4,Phase 1
28 Vitamin B Complex Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Trace Elements Phase 4,Phase 1
31 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Micronutrients Phase 4,Phase 1
33 Vitamin B9 Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Folate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
35 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Renal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Topoisomerase Inhibitors Phase 4,Phase 2,Not Applicable,Early Phase 1
40 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
41 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
42 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
43 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable,Early Phase 1
44 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
45 methicillin Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
46 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
47 Antibodies Phase 4,Phase 3,Phase 2
48 Immunoglobulins Phase 4,Phase 3,Phase 2
49 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
50 Vitamin B2 Phase 4

Interventional clinical trials:

(show top 50) (show all 153)
# Name Status NCT ID Phase Drugs
1 CERAMENTâ„¢|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
3 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
4 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
5 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
6 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
7 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
8 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
9 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
10 Use of Santyl Within an Accountable Care Organization Withdrawn NCT02716519 Phase 4
11 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
12 Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures Terminated NCT02400112 Phase 4 Vancomycin
13 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
14 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
15 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
16 Platelet Gel in Systemic Sclerosis Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
17 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
18 Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
19 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
20 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
21 Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers Completed NCT01586481 Phase 3
22 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Active, not recruiting NCT03174366 Phase 3 Denosumab
23 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
24 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
25 Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections. Terminated NCT02202135 Phase 3 Ceftaroline fosamil;Vancomycin;Aztreonam
26 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
27 Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections Completed NCT00423657 Phase 3 ceftaroline;vancomycin plus aztreonam;Placebo
28 Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections Completed NCT00424190 Phase 3 IV Vancomycin plus IV Aztreonam;Ceftaroline
29 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
30 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
31 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
32 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
33 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
34 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
35 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
36 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
37 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
38 Study of Octanorm Subcutaneous IG in Patients With PID Active, not recruiting NCT01888484 Phase 3
39 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
40 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
41 Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
42 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
43 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
44 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
45 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
46 Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Completed NCT02066402 Phase 3 Tedizolid (BAY119-2631);Placebo Tedizolid (BAY119-2631);Linezolid;Placebo Linezolid
47 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
48 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
49 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
50 Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Terminated NCT03091439 Phase 2 Dalbavancin;Standard of Care

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: osteomyelitis

Sources

Genetic Tests for Osteomyelitis

About this section

Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 30
Sources

Anatomical Context for Osteomyelitis

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MalaCards organs/tissues related to Osteomyelitis:

42
Bone, Testes, Skin, Bone Marrow, Spinal Cord, Prostate, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

20
Bone Or
Sources

Publications for Osteomyelitis

About this section

Articles related to Osteomyelitis:

(show top 50) (show all 3984)
# Title Authors Year
1
Evolution of chronic recurrent multifocal osteomyelitis in a child shown by MRI. ( 30364530 )
2019
2
The Dilemma of Chronic Recurrent Multifocal Osteomyelitis. ( 30616941 )
2019
3
Partial Oral Therapy for Osteomyelitis and Endocarditis - Is It Time? ( 30699312 )
2019
4
Nocardial clival osteomyelitis secondary to sphenoid sinusitis: an atypical skull base infection. ( 30607637 )
2019
5
An Unusual Etiology for Osteomyelitis in an Immunocompetent Host. ( 30615134 )
2019
6
Value of MRI in changing of diabetic foot osteomyelitis management. ( 30618124 )
2019
7
Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association. ( 30622895 )
2019
8
Extended field of view magnetic resonance imaging for suspected osteomyelitis in very young children: is it useful? ( 30623210 )
2019
9
Current health and economic burden of chronic diabetic osteomyelitis. ( 30625012 )
2019
10
Clinical analysis of 17 cases of neonatal osteomyelitis: A retrospective study. ( 30633229 )
2019
11
Short- versus long-course antibiotics in osteomyelitis: A systematic review and meta-analysis. ( 30639627 )
2019
12
Cervical osteomyelitis: A new identity of dreaded complication following pharyngeal cancer treatment. ( 30641205 )
2019
13
Factors Predicting Positive Culture in CT-Guided Bone Biopsy Performed for Suspected Osteomyelitis. ( 30645166 )
2019
14
Dalbavancin for the Treatment of Osteomyelitis in Adult Patients: A Randomized Clinical Trial of Efficacy and Safety. ( 30648126 )
2019
15
Asymmetric limb lengthening in the treatment of tibial hemimelia caused by osteomyelitis: A case report. ( 30653110 )
2019
16
Imaging of Emphysematous Osteomyelitis. ( 30653838 )
2019
17
Unrecognized staphylococcal vertebral osteomyelitis leading to fatal outcome in a previously healthy patient. ( 30656049 )
2019
18
MRI Diagnosis for Post-Traumatic Osteomyelitis of Extremities Using Conventional Metal-Artifact Reducing Protocols: Revisited. ( 30660474 )
2019
19
In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatments. ( 30678975 )
2019
20
Osteomyelitis of the Calcaneus With Pathologic Fracture. ( 30685422 )
2019
21
Diagnostic Utility of Erythrocyte Sedimentation Rate and C-Reactive Protein in Osteomyelitis of the Foot in Persons Without Diabetes. ( 30685423 )
2019
22
Outcome After Surgical Treatment of Calcaneal Osteomyelitis. ( 30688528 )
2019
23
Surgical Treatment With Thoracic Pedicle Screw Fixation of Vertebral Osteomyelitis With Long-Term Follow-up. ( 30690618 )
2019
24
Palatal actinomycosis osteomyelitis-Complication of impacted tooth in a diabetic. ( 30820977 )
2019
25
The role of real-time PCR testing in the investigation of paediatric patients with community-onset osteomyelitis and septic arthritis. ( 30706296 )
2019
26
Actinomyces Orbital Osteomyelitis in the Setting of Multiple Myeloma and Bisphosphonate-Related Osteonecrosis. ( 30763286 )
2019
27
The Impact of using the term "Diabetic Ear" for the patients with Skull Base Osteomyelitis. ( 30697101 )
2019
28
Post-traumatic osteomyelitis in Middle East war-wounded civilians: resistance to first-line antibiotics in selected bacteria over the decade 2006-2016. ( 30704410 )
2019
29
Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice. ( 30711175 )
2019
30
Single-stage treatment of infected tibial non-unions and osteomyelitis with bone marrow granulocytes precursors protecting bone graft. ( 30712154 )
2019
31
Effect of Causative Micro-organisms on Patterns of Labeled White Blood Cells in Osteomyelitis. ( 30713375 )
2019
32
Increased Fragility Fracture Rates in Older Men with Osteomyelitis. ( 30715288 )
2019
33
Osteomyelitis: A Rare Complication After Subpectoral Biceps Tenodesis. ( 30719484 )
2019
34
Discordant isolates in bone specimens from patients with recurrent foot osteomyelitis. ( 30719591 )
2019
35
Surgery is safe and effective when indicated in the acute phase of hematogenous pyogenic vertebral osteomyelitis. ( 30729831 )
2019
36
Chronic Candida osteomyelitis of hard palate and nose: A diagnostic quandary. ( 30733914 )
2019
37
Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. ( 30735536 )
2019
38
Experimental Candida albicans osteomyelitis: Microbiologic, antigenic, histologic, and 18FDG-PET-CT imaging characteristics in a newly established rabbit model. ( 30753591 )
2019
39
L-shaped corticotomy with bone flap sliding in the management of chronic tibial osteomyelitis: surgical technique and clinical results. ( 30755228 )
2019
40
Modular megaprosthesis as definite treatment of femur osteomyelitis. ( 30771799 )
2019
41
Role of fluoroethyl tyrosine positron emission tomography-computed tomography scan in differentiating ewing's sarcoma from osteomyelitis. ( 30774555 )
2019
42
Percutaneous image-guided bone biopsy of osteomyelitis in the foot and pelvis has a low impact on guiding antibiotics management: a retrospective analysis of 60 bone biopsies. ( 30778640 )
2019
43
The use of chimeric musculocutaneous posterior interosseous artery flaps for treatment of osteomyelitis and soft tissue defect in hand. ( 30779433 )
2019
44
Systematic review of randomized controlled trials on antibiotic treatment for osteomyelitis in diabetes. ( 30785639 )
2019
45
Use of Ceftaroline Fosamil in Osteomyelitis: CAPTURE Study Experience. ( 30791894 )
2019
46
Management of Mandibular Osteomyelitis With Segmental Resection, Nerve Preservation, and Immediate Reconstruction. ( 30797754 )
2019
47
Early diagnosis of jaw osteomyelitis by easy digitalized panoramic analysis. ( 30800645 )
2019
48
Mucormycotic Osteomyelitis Involving the Maxilla: A Rare Case Report and Review of the Literature. ( 30805232 )
2019
49
Comparative evaluation of SPECT/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis. ( 30806799 )
2019
50
Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis. ( 30813284 )
2019
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Variations for Osteomyelitis

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Expression for Osteomyelitis

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Search GEO for disease gene expression data for Osteomyelitis.
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Pathways for Osteomyelitis

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Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.08 CTSK CXCL8 IFNG IFNGR1 IL10 IL1A
2
PEDF Induced Signaling 65
Show member pathways
 13.77 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
3
TGF-Beta Pathway 65
Show member pathways
 13.6 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
4
Akt Signaling 65
Show member pathways
 13.47 BMP2 CXCL8 IL10 IL1A IL1B IL6
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.47 CXCL8 IFNG IFNGR1 IL10 IL1A IL1B
6
PAK Pathway 65
Show member pathways
 13.37 BMP2 CXCL8 IL10 IL1A IL1B IL6
7
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.3 CTSK CXCL8 IFNG IFNGR1 IL10 IL1B
8
Human cytomegalovirus infection 38
Show member pathways
 13.02 CXCL8 IFNGR1 IL1B IL6 PPP3CA TNF
9
Allograft rejection 1 38
Show member pathways
 13 CXCL8 IFNG IFNGR1 IL10 IL1A IL1B
10
Pathways in cancer 38
12.88 BMP2 CXCL8 IFNG IFNGR1 IL6
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.82 CXCL8 IFNG IL1B IL6 TNF
12
NF-KappaB Family Pathway 65
Show member pathways
 12.76 BMP2 IL1A IL1B IL6 TNF
13
4-1BB Pathway 65
Show member pathways
 12.74 IFNG IFNGR1 IL1A IL1B TNF
14
Th17 cell differentiation 38
Show member pathways
 12.72 IFNG IFNGR1 IL10 IL1A IL1B IL6
15
Immune response NFAT in immune response 23
Show member pathways
 12.7 IFNG IFNGR1 IL10 PPP3CA TNF
16
Influenza A 38
Show member pathways
 12.7 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
17
NF-kappaB Signaling 4
12.7 IFNG IL10 IL1B IL1RN PPP3CA TNF
18
TRAF Pathway 65
Show member pathways
 12.68 IL1A IL1B PPP3CA TNF TNFSF11
19
Immune response IL-23 signaling pathway 23
Show member pathways
 12.66 IFNG IL10 IL1B IL6 TNF
20
T cell receptor signaling pathway 38
Show member pathways
 12.57 IFNG IL10 IL1A IL1B IL6 PPP3CA
21
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.54 IFNG IFNGR1 PPP3CA TNF
22
RANK Signaling in Osteoclasts 65
Show member pathways
 12.5 ACP5 CTSK IL10 PPP3CA TNFSF11
23
Toll Comparative Pathway 65
Show member pathways
 12.46 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
24
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.43 IFNG IFNGR1 IL10 IL6
25
IL-17 Family Signaling Pathways 66
Show member pathways
 12.43 CXCL8 IFNG IL1B IL6 TNF
26
Toxoplasmosis 38
Show member pathways
 12.41 IFNG IFNGR1 IL10 IL1A IL1B TNF
27
Selenium Micronutrient Network 1
Show member pathways
 12.39 IFNG IL1B IL6 TNF
28
IL-1 Family Signaling Pathways 66
Show member pathways
 12.38 CXCL8 IL1A IL1B IL1RN IL6 TNF
29
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.36 BMP2 CXCL8 IFNG IL10 IL1A IL1B
30
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.33 CXCL8 IL1A IL6 TNF
31
Bacterial infections in CF airways 23
Show member pathways
 12.33 CXCL8 IFNG IFNGR1 IL1B IL6 TNF
32
C-type lectin receptor signaling pathway 38
Show member pathways
 12.32 IL10 IL1B IL6 PPP3CA TNF
33
Necroptosis 38
Show member pathways
 12.32 IFNG IFNGR1 IL1A IL1B TNF
34
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.28 CXCL8 IL10 IL1A IL1B IL1RN IL6
35
Colorectal Cancer Metastasis 65
12.25 IFNG IFNGR1 IL6 TNF
36
Cellular senescence (KEGG) 38
12.24 CXCL8 IL1A IL6 PPP3CA
37
Th1 Differentiation Pathway 66
Show member pathways
 12.22 IFNG IFNGR1 IL10 IL1B IL6 TNF
38
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.21 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
39
Tuberculosis 38
12.18 IFNG IFNGR1 IL10 IL1A IL1B IL6
40
Fluid shear stress and atherosclerosis 38
12.17 IFNG IL1A IL1B TNF
41
Interleukin-4 and 13 signaling 67
12.15 CXCL8 IL10 IL1A IL1B IL6 TNF
42
Adipogenesis 1
12.14 BMP2 IL6 LPIN2 TNF
43
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.12 IFNG IL1B IL6 TNF
44
Senescence and Autophagy in Cancer 1
12.1 BMP2 CXCL8 IFNG IL1A IL1B IL6
45
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.08 IFNG IL10 IL6 TNF
46
Spinal Cord Injury 1
12.08 CXCL8 IFNG IL1A IL1B IL6 PPP3CA
47
AGE-RAGE signaling pathway in diabetic complications 38
12.06 CXCL8 IL1A IL1B IL6 TNF
48
Amoebiasis 38
12.04 CXCL8 IFNG IL10 IL1B IL6 TNF
49
Hematopoietic cell lineage 38
11.99 IL1A IL1B IL6 TNF
50
NF-kappa B signaling pathway 38
11.98 CXCL8 IL1B TNF TNFSF11
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GO Terms for Osteomyelitis

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Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BMP2 CTSK CXCL8 IFNG IL10 IL1A
2 extracellular space GO:0005615 9.36 BMP2 CTSK CXCL8 IFNG IL10 IL1A

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.97 BMP2 IFNG IL1B TNF
2 positive regulation of gene expression GO:0010628 9.97 BMP2 IFNG IL1A IL1B IL6 PPP3CA
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B IL1RN TNF TNFSF11
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TNF TNFSF11
5 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IL10 IL1B IL1RN IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.89 ACP5 IL6 TNF
7 ossification GO:0001503 9.89 ACP5 BMP2 TNFSF11
8 calcium-mediated signaling GO:0019722 9.88 CXCL8 PPP3CA TNFSF11
9 neutrophil chemotaxis GO:0030593 9.88 CXCL8 IL1B IL1RN
10 cellular response to organic cyclic compound GO:0071407 9.87 BMP2 IL1B TNF
11 positive regulation of JNK cascade GO:0046330 9.87 IL1B IL1RN TNF TNFSF11
12 regulation of insulin secretion GO:0050796 9.86 IFNG IL1B TNF
13 inflammatory response GO:0006954 9.86 BMP2 CXCL8 IL10 IL1A IL1B IL1RN
14 humoral immune response GO:0006959 9.85 IFNG IL6 TNF
15 interleukin-1-mediated signaling pathway GO:0070498 9.83 IL1A IL1B IL1RN
16 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL1RN IL6 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IFNG IL1B TNF
18 immune response GO:0006955 9.81 CXCL8 IFNG IL10 IL1A IL1B IL1RN
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
20 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 IL10 IL1B IL6 PPP3CA TNF TNFSF11
21 positive regulation of cytokine secretion GO:0050715 9.79 IL10 IL1A TNF
22 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
23 bone resorption GO:0045453 9.77 ACP5 CTSK TNFSF11
24 positive regulation of osteoclast differentiation GO:0045672 9.76 IFNG TNF TNFSF11
25 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
27 regulation of osteoclast differentiation GO:0045670 9.72 TNF TNFSF11
28 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG IL1B TNF
30 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG IFNGR1
31 negative regulation of interleukin-12 production GO:0032695 9.71 ACP5 IL10
32 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
34 response to glucocorticoid GO:0051384 9.71 IL10 IL1RN IL6 TNF
35 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL10 IL1RN
36 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
37 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
39 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
40 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
42 positive regulation of neuroinflammatory response GO:0150078 9.67 IL1B IL6 TNF
43 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL1RN IL6
44 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
45 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IFNG IL1B TNF
47 fever generation GO:0001660 9.62 IL1A IL1B
48 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
49 positive regulation of vitamin D biosynthetic process GO:0060557 9.61 IFNG TNF
50 cytokine-mediated signaling pathway GO:0019221 9.61 CXCL8 IFNGR1 IL10 IL1A IL1B IL1RN

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 BMP2 CXCL8 IFNG IL10 IL1A IL1B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
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Sources for Osteomyelitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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