MCID: OST017
MIFTS: 64

Osteomyelitis

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 76 53 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1019
ICD9CM 35 730.1 730.10
MeSH 44 D010019
SNOMED-CT 68 40970001
ICD10 33 M86 M86.9

Summaries for Osteomyelitis

NIH Rare Diseases : 53 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to chronic recurrent multifocal osteomyelitis and mycobacterium fortuitum, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and bone marrow, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 76 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)
# Related Disease Score Top Affiliating Genes
1 chronic recurrent multifocal osteomyelitis 34.3 FBLIM1 IL1B LPIN2
2 mycobacterium fortuitum 32.3 CXCL8 IFNGR1
3 toxic shock syndrome 31.6 CXCL8 IFNG IL10 IL1B IL6 TNF
4 osteopetrosis, autosomal dominant 2 31.3 ACP5 CTSK TNFSF11
5 melioidosis 30.1 IFNG IL10 IL6 TNF
6 sporotrichosis 30.1 IFNG IL10
7 q fever 30.1 IFNG IL10 IL1B IL6 TNF
8 osteonecrosis 30.0 ACP5 BMP2 TNFSF11
9 endocarditis 30.0 CXCL8 IL10 IL6 TNF
10 synovitis 29.9 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
11 arthritis 29.9 TNFSF11 TNF IL6 IL1RN IL1B IL1A
12 necrotizing fasciitis 29.9 CXCL8 IL1RN IL6
13 salmonellosis 29.9 IFNG IFNGR1 IL1B
14 pneumonia 29.8 CXCL8 IL10 IL1B IL6 TNF
15 fasciitis 29.8 CXCL8 IL6 TNF
16 neuritis 29.8 IFNG IL1B TNF
17 meningitis 29.8 CXCL8 IFNG IL10 IL1B IL6 TNF
18 typhoid fever 29.8 IFNG IFNGR1 IL1B IL6 TNF
19 rheumatic fever 29.8 IL10 IL6 TNF
20 interferon gamma, receptor 1, deficiency 29.8 IFNG IFNGR1
21 poliomyelitis 29.7 IFNG IL10 TNF
22 acute pyelonephritis 29.7 CXCL8 IL10 IL6
23 critical limb ischemia 29.7 IL6 TNF
24 paracoccidioidomycosis 29.7 IFNG IL10 IL6 TNF
25 myeloma, multiple 29.6 CXCL8 IL6 TNF TNFSF11
26 familial mediterranean fever 29.6 IL1B IL1RN TNF
27 extrapulmonary tuberculosis 29.6 IFNG IL10 IL1B
28 systemic lupus erythematosus 29.6 CXCL8 IFNG IL10 IL1B IL6 TNF
29 pyelonephritis 29.6 CXCL8 IL10 IL1B IL6 TNF
30 otitis media 29.6 CXCL8 IL10 IL1B IL6 TNF
31 arteries, anomalies of 29.6 IL1B IL6 TNF
32 peripheral nervous system disease 29.6 IL6 SPTLC1 TNF
33 sarcoidosis 1 29.6 IFNG IL1B TNF
34 acquired immunodeficiency syndrome 29.6 IFNG IL10 IL1B IL6 TNF
35 human immunodeficiency virus infectious disease 29.5 IFNG IL10 IL6 TNF
36 aspergillosis 29.5 IFNG IL10 TNF
37 reactive arthritis 29.5 IFNG IL10 TNF
38 ulcerative colitis 29.5 CXCL8 IFNG IL10 IL1B IL6 TNF
39 colitis 29.5 CXCL8 IFNG IL10 IL1B IL6 TNF
40 appendicitis 29.5 CXCL8 IL10 IL1B IL6 TNF
41 diabetes mellitus 29.5 IFNG IL1A IL1B IL1RN IL6 TNF
42 peritonitis 29.5 CXCL8 IL10 IL1B IL6 TNF
43 spondylitis 29.5 IL1RN IL6 TNF
44 bacterial sepsis 29.5 CXCL8 IL10 TNF
45 acute transverse myelitis 29.4 CXCL8 IL10 IL6
46 radiculopathy 29.4 CXCL8 IL1A IL6
47 adult-onset still's disease 29.4 IL1B IL1RN IL6 TNF
48 common variable immunodeficiency 29.4 IFNG IL10 IL6 TNF
49 joint disorders 29.4 IL1B IL1RN IL6 TNF TNFSF11
50 haemophilus influenzae 29.4 CXCL8 IL1B TNF

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


bone pain, pain in limb

MGI Mouse Phenotypes related to Osteomyelitis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ANO5 BMP2 CTSK IFNG IFNGR1 IL10
2 hematopoietic system MP:0005397 10.32 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
3 immune system MP:0005387 10.28 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
4 cardiovascular system MP:0005385 10.25 BMP2 IFNG IFNGR1 IL10 IL1A IL1B
5 cellular MP:0005384 10.24 ANO5 BMP2 CTSK FBLIM1 IFNG IFNGR1
6 growth/size/body region MP:0005378 10.24 BMP2 CTSK IFNG IL10 IL1B IL1RN
7 mortality/aging MP:0010768 10.15 BMP2 IFNG IFNGR1 IL10 IL1B IL1RN
8 craniofacial MP:0005382 10.07 BMP2 CTSK IFNG IL10 IL1B TNF
9 integument MP:0010771 10.06 IFNG IFNGR1 IL10 IL1A IL1B IL1RN
10 digestive/alimentary MP:0005381 10.05 BMP2 CTSK IFNG IFNGR1 IL10 IL6
11 nervous system MP:0003631 9.9 BMP2 CTSK IFNG IFNGR1 IL10 IL1B
12 muscle MP:0005369 9.87 ANO5 IFNG IL10 IL6 PPP3CA TNF
13 neoplasm MP:0002006 9.86 IFNG IFNGR1 IL10 IL1A IL1B IL6
14 reproductive system MP:0005389 9.7 ANO5 BMP2 IFNG IFNGR1 IL10 IL1RN
15 skeleton MP:0005390 9.36 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 58-05-9 6006 143
2
Trimethoprim Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 738-70-5 5578
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 85721-33-1 2764
4
Sulfamethoxazole Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 723-46-6 5329
5
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 1404-90-6 14969 441141
6
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
7
Doxycycline Approved, Investigational, Vet_approved Phase 4,Early Phase 1 564-25-0 54671203
8
Levofloxacin Approved, Investigational Phase 4,Early Phase 1 100986-85-4 149096
9
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 165800-03-3 441401
10
Cefoxitin Approved Phase 4,Early Phase 1 35607-66-0 441199
11
Rifampicin Approved Phase 4,Early Phase 1 13292-46-1 5458213 5381226
12
Cefepime Approved, Investigational Phase 4,Phase 2,Early Phase 1 88040-23-7 5479537
13
Cefotaxime Approved Phase 4,Early Phase 1 63527-52-6 456256 5742673
14
Fusidic Acid Approved, Investigational Phase 4,Phase 2,Phase 3 6990-06-3 3000226
15
Ofloxacin Approved Phase 4,Early Phase 1 82419-36-1 4583
16
Ceftriaxone Approved Phase 4,Early Phase 1 73384-59-5 5479530 5361919
17
Nafcillin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 985-16-0, 147-52-4 8982
18
Teicoplanin Approved, Investigational Phase 4,Phase 3,Phase 2 61036-62-2
19
Dalbavancin Approved, Investigational Phase 4,Phase 3,Phase 2 91097-81-3, 171500-79-1 122186
20
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 18323-44-9 29029
21
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 59-30-3 6037
23
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
24 Gentamicins Phase 4,Early Phase 1
25 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
26 Vitamin B9 Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
27 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
28 Topoisomerase Inhibitors Phase 4,Phase 2,Not Applicable,Early Phase 1
29 Vitamin B Complex Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
30 Anti-Infective Agents, Urinary Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
31 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
32 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Folic Acid Antagonists Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
34 Renal Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
35 Antimalarials Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
36 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
38 Folate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
39 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable,Early Phase 1
40 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
42 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
43 Antibodies Phase 4,Phase 3,Phase 2
44 Immunoglobulins Phase 4,Phase 3,Phase 2
45 Micronutrients Phase 4,Phase 1
46 Trace Elements Phase 4,Phase 1
47 methicillin Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
48 Nucleic Acid Synthesis Inhibitors Phase 4,Early Phase 1
49 Cytochrome P-450 CYP3A Inducers Phase 4,Early Phase 1
50 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 146)
# Name Status NCT ID Phase Drugs
1 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
3 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
4 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
5 Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
6 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
7 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
8 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
9 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
10 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
11 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
12 Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures Terminated NCT02400112 Phase 4 Vancomycin
13 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
14 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
15 Use of Santyl Within an Accountable Care Organization Withdrawn NCT02716519 Phase 4
16 Platelet Gel in Systemic Sclerosis Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
17 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
18 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
19 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
20 Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers Completed NCT01586481 Phase 3
21 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
22 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
23 Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections Completed NCT00423657 Phase 3 ceftaroline;vancomycin plus aztreonam;Placebo
24 Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections Completed NCT00424190 Phase 3 IV Vancomycin plus IV Aztreonam;Ceftaroline
25 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
26 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
27 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
28 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
29 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
30 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
31 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
32 Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
33 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
34 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
35 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
36 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
37 Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Completed NCT02066402 Phase 3 Tedizolid (BAY119-2631);Placebo Tedizolid (BAY119-2631);Linezolid;Placebo Linezolid
38 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
39 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
40 Study of Octanorm Subcutaneous IG in Patients With PID Recruiting NCT01888484 Phase 3
41 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
42 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Active, not recruiting NCT03174366 Phase 3 Denosumab
43 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
44 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
45 Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections. Terminated NCT02202135 Phase 3 Ceftaroline fosamil;Vancomycin;Aztreonam
46 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
47 Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
48 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
49 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
50 Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Participants With Osteomyelitis Completed NCT02685033 Phase 2 Dalbavancin;Comparator

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: osteomyelitis

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 29

Anatomical Context for Osteomyelitis

MalaCards organs/tissues related to Osteomyelitis:

41
Bone, Testes, Bone Marrow, Skin, Spinal Cord, Lung, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

19
Bone Or

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 2521)
# Title Authors Year
1
Evolution of chronic recurrent multifocal osteomyelitis in a child shown by MRI. ( 30364530 )
2019
2
<i>Mycobacterium kansasii</i> osteomyelitis - a masquerading disease. ( 29568531 )
2018
3
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report. ( 29443819 )
2018
4
The role of whole-body magnetic resonance imaging in diagnosing chronic recurrent multifocal osteomyelitis. ( 29904495 )
2018
5
The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29718410 )
2018
6
The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29596638 )
2018
7
Pyomyositis and osteomyelitis: an unusual cause of abdominal pain. ( 29559487 )
2018
8
Biologic treatment for chronic recurrent multifocal osteomyelitis: report of four cases and review of the literature. ( 29127574 )
2018
9
A severe case of &amp;lt;em&amp;gt;Mycobacterium ulcerans&amp;lt;/em&amp;gt; (Buruli ulcer) osteomyelitis requiring a below-knee amputation. ( 29642809 )
2018
10
Vancomycin incorporated chitosan/gelatin coatings coupled with TiO<sub>2</sub>-SrHAP surface modified cp-titanium for osteomyelitis treatment. ( 29395341 )
2018
11
Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )
2018
12
Response to Dr. Jolobe: &amp;quot;Optimising diagnostic strategies in emphysematous osteomyelitis&amp;quot;. ( 29939346 )
2018
13
Optimising diagnostic strategies in emphysematous osteomyelitis. ( 29939336 )
2018
14
Abscess originating from osteomyelitis as a cause of lower urinary tract symptoms (LUTS) and acute urinary retention. ( 29930185 )
2018
15
Chronic recurrent multifocal osteomyelitis in pediatrics: A diagnostic challenge. ( 29776891 )
2018
16
Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. ( 29124297 )
2018
17
Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity. ( 29425755 )
2018
18
Escherichia coli isolates from femoral bone marrow of broilers exhibit diverse pheno- and genotypic characteristics that do not correlate with macroscopic lesions of bacterial chondronecrosis with osteomyelitis (BCO). ( 29451003 )
2018
19
In this issue - July 2018: Recommendations on equine PPIDa88A^a88Prevalence of alphaviruses in horses in North Queenslanda88A^a88Endoscopic transection of uterine tube bands in maresa88A^a88Radiography vs CT in osteomyelitis in foalsa88A^a88Transmission of BVDV to alpacasa88A^a88Dietary pH balance in cows with milk fever. ( 29944748 )
2018
20
Osteomyelitis of the pubic symphysis after transrectal biopsies of the prostate. ( 29935934 )
2018
21
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis. ( 29866071 )
2018
22
Management of Pediatric Acute Hematogenous Osteomyelitis, Part I: Antimicrobial Stewardship Approach and Review of Therapies for Methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes, and Kingella kingae. ( 29920709 )
2018
23
Genome Sequence of Staphylococcus aureus Ex1, Isolated from a Patient with Spinal Osteomyelitis. ( 29954915 )
2018
24
Dynamic contrast-enhanced magnetic resonance imaging for differentiating osteomyelitis from acute neuropathic arthropathy in the complicated diabetic foot. ( 29654348 )
2018
25
Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )
2018
26
Chronic non-suppurative mandibular osteomyelitis with proliferative periostitis: A review. ( 29435520 )
2018
27
Bone inflammation and chronic recurrent multifocal osteomyelitis. ( 29565497 )
2018
28
Update on the genetics of nonbacterial osteomyelitis in humans. ( 29912021 )
2018
29
Chronic Recurrent Multifocal Osteomyelitis of the Mandible: A Diagnostic Challenge. ( 29652766 )
2018
30
Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products. ( 29391581 )
2018
31
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
32
Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical picture and radiography. ( 29844940 )
2018
33
Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis. ( 29403199 )
2018
34
Mandibular Involvement in Recurrent Multifocal Osteomyelitis Associated with SAPHO Syndrome. ( 29387665 )
2018
35
Cranial Osteomyelitis: The Old Enemy Is Back. ( 29958369 )
2018
36
Campylobacter jejuni vertebral osteomyelitis or tuberculosis: persisting diagnostic ambiguity - Authors' reply. ( 29412960 )
2018
37
Beyond ulcers and osteomyelitis: imaging of less common musculoskeletal complications in diabetes mellitus. ( 29419313 )
2018
38
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
39
Lower-Extremity Osteomyelitis Treatment Using Calcium Sulfate/Hydroxyapatite Bone Void Filler with Antibiotics <sub>Seven-Year Retrospective Study</sub>. ( 29932757 )
2018
40
Comparison of conventional radiography and computed tomography as aids in the diagnosis of osteomyelitis in 11 foals. ( 29944745 )
2018
41
Chronic recurrent multifocal osteomyelitis: a case report. ( 29454377 )
2018
42
COULD OZONE TREATMENT BE A PROMISING ALTERNATIVE FOR OSTEOMYELITIS? AN EXPERIMENTAL STUDY. ( 29977149 )
2018
43
Medication-related osteonecrosis of the jaw, osteoradionecrosis, and osteomyelitis: A comparative histopathological study. ( 29723337 )
2018
44
A case of chronic granulomatous craniofacial osteomyelitis. ( 29942784 )
2018
45
Serum procollagen type 1 N propeptide: A novel diagnostic test for diabetic foot osteomyelitis - A case-control study. ( 29937901 )
2018
46
Going Bone Deep: Osseous Rosai-Dorfman Disease in an Adult with Recurrent, Culture-Negative Osteomyelitis. ( 29888015 )
2018
47
Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )
2018
48
Osteomyelitis in Cat-Scratch Disease: A Never-Ending Dilemma-A Case Report and Literature Review. ( 29808150 )
2018
49
Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder. ( 29425711 )
2018
50
Combined Labeled Leukocyte and Technicium 99 Sulfur Colloid Bone Marrow Imaging: Differentiating Primary Pyomyositis Pseudotumor from Osteomyelitis and Multiple Bone Infarcts. ( 29772988 )
2018

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 CTSK CXCL8 IFNG IFNGR1 IL10 IL1A
2
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13.77 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
3
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13.6 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
4
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13.47 BMP2 CXCL8 IL10 IL1A IL1B IL6
5
Show member pathways
13.47 CXCL8 IFNG IFNGR1 IL10 IL1A IL1B
6
Show member pathways
13.37 BMP2 CXCL8 IL10 IL1A IL1B IL6
7
Show member pathways
13.13 CTSK CXCL8 IFNG IFNGR1 IL10 IL1B
8
Show member pathways
13.11 CXCL8 IFNGR1 IL1B IL6 PPP3CA TNF
9
Show member pathways
13 CXCL8 IFNG IFNGR1 IL10 IL1A IL1B
10
Show member pathways
12.91 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
11 12.88 BMP2 CXCL8 IFNG IFNGR1 IL6
12
Show member pathways
12.82 CXCL8 IFNG IL1B IL6 TNF
13
Show member pathways
12.76 BMP2 IL1A IL1B IL6 TNF
14
Show member pathways
12.74 IFNG IFNGR1 IL1A IL1B TNF
15
Show member pathways
12.72 IFNG IFNGR1 IL10 IL1A IL1B IL6
16
Show member pathways
12.7 IFNG IFNGR1 IL10 PPP3CA TNF
17 12.7 IFNG IL10 IL1B IL1RN PPP3CA TNF
18
Show member pathways
12.68 IL1A IL1B PPP3CA TNF TNFSF11
19
Show member pathways
12.66 IFNG IL10 IL1B IL6 TNF
20
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12.57 IFNG IL10 IL1A IL1B IL6 PPP3CA
21
Show member pathways
12.54 IFNG IFNGR1 PPP3CA TNF
22
Show member pathways
12.5 ACP5 CTSK IL10 PPP3CA TNFSF11
23
Show member pathways
12.46 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
24
Show member pathways
12.43 IFNG IFNGR1 IL10 IL6
25
Show member pathways
12.43 CXCL8 IFNG IL1B IL6 TNF
26
Show member pathways
12.41 IFNG IFNGR1 IL10 IL1A IL1B TNF
27
Show member pathways
12.39 IFNG IL1B IL6 TNF
28
Show member pathways
12.38 CXCL8 IL1A IL1B IL1RN IL6 TNF
29
Show member pathways
12.36 BMP2 CXCL8 IFNG IL10 IL1A IL1B
30
Show member pathways
12.33 CXCL8 IL1A IL6 TNF
31
Show member pathways
12.33 CXCL8 IFNG IFNGR1 IL1B IL6 TNF
32
Show member pathways
12.32 IL10 IL1B IL6 PPP3CA TNF
33
Show member pathways
12.32 IFNG IFNGR1 IL1A IL1B TNF
34 12.28 CXCL8 IL10 IL1A IL1B IL1RN IL6
35 12.25 IFNG IFNGR1 IL6 TNF
36 12.24 CXCL8 IL1A IL6 PPP3CA
37
Show member pathways
12.22 IFNG IFNGR1 IL10 IL1B IL6 TNF
38
Show member pathways
12.21 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
39 12.18 IFNG IFNGR1 IL10 IL1A IL1B IL6
40 12.17 IFNG IL1A IL1B TNF
41 12.15 CXCL8 IL10 IL1A IL1B IL6 TNF
42 12.14 BMP2 IL6 LPIN2 TNF
43
Show member pathways
12.12 IFNG IL1B IL6 TNF
44 12.1 BMP2 CXCL8 IFNG IL1A IL1B IL6
45 12.08 IFNG IL10 IL6 TNF
46 12.08 CXCL8 IFNG IL1A IL1B IL6 PPP3CA
47 12.06 CXCL8 IL1A IL1B IL6 TNF
48 12.04 CXCL8 IFNG IL10 IL1B IL6 TNF
49 11.99 IL1A IL1B IL6 TNF
50 11.98 CXCL8 IL1B TNF TNFSF11

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BMP2 CTSK CXCL8 IFNG IL10 IL1A
2 extracellular space GO:0005615 9.36 BMP2 CTSK CXCL8 IFNG IL10 IL1A

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.97 BMP2 IFNG IL1B TNF
2 positive regulation of gene expression GO:0010628 9.97 BMP2 IFNG IL1A IL1B IL6 PPP3CA
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B IL1RN TNF TNFSF11
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TNF TNFSF11
5 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IL10 IL1B IL1RN IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.9 ACP5 IL6 TNF
7 ossification GO:0001503 9.89 ACP5 BMP2 TNFSF11
8 calcium-mediated signaling GO:0019722 9.88 CXCL8 PPP3CA TNFSF11
9 neutrophil chemotaxis GO:0030593 9.88 CXCL8 IL1B IL1RN
10 cellular response to organic cyclic compound GO:0071407 9.87 BMP2 IL1B TNF
11 positive regulation of JNK cascade GO:0046330 9.87 IL1B IL1RN TNF TNFSF11
12 regulation of insulin secretion GO:0050796 9.86 IFNG IL1B TNF
13 inflammatory response GO:0006954 9.86 BMP2 CXCL8 IL10 IL1A IL1B IL1RN
14 humoral immune response GO:0006959 9.85 IFNG IL6 TNF
15 interleukin-1-mediated signaling pathway GO:0070498 9.83 IL1A IL1B IL1RN
16 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL1RN IL6 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IFNG IL1B TNF
18 positive regulation of JUN kinase activity GO:0043507 9.81 IL1B IL1RN TNF
19 immune response GO:0006955 9.81 CXCL8 IFNG IL10 IL1A IL1B IL1RN
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
21 response to glucocorticoid GO:0051384 9.8 IL10 IL1B IL1RN IL6 TNF
22 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 IL10 IL1B IL6 PPP3CA TNF TNFSF11
23 positive regulation of cytokine secretion GO:0050715 9.79 IL10 IL1A TNF
24 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
25 bone resorption GO:0045453 9.77 ACP5 CTSK TNFSF11
26 positive regulation of osteoclast differentiation GO:0045672 9.76 IFNG TNF TNFSF11
27 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
28 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
29 regulation of osteoclast differentiation GO:0045670 9.72 TNF TNFSF11
30 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
31 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.72 IFNG IFNGR1
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG IL1B TNF
33 negative regulation of interleukin-12 production GO:0032695 9.71 ACP5 IL10
34 positive regulation of astrocyte differentiation GO:0048711 9.71 BMP2 IL1B
35 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
37 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL10 IL1RN
38 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
39 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
40 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
41 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
42 negative regulation of glutamate secretion GO:0014050 9.68 IL1B IL1RN
43 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
44 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
45 positive regulation of neuroinflammatory response GO:0150078 9.67 IL1B IL6 TNF
46 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL1RN IL6
47 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.65 IL1B IL1RN TNF
49 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IFNG IL1B TNF

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 BMP2 CXCL8 IFNG IL10 IL1A IL1B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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