Osteomyelitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OST017 MIFTS: 64	Osteomyelitis Categories: Bone diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis ¹² ⁷⁶ ⁵³ ²⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Other osteopathies

Osteomyelitis

Osteomyelitis, unspecified

External Ids:

Disease Ontology ¹² DOID:1019

ICD9CM ³⁵ 730.1 730.10

MeSH ⁴⁴ D010019

SNOMED-CT ⁶⁸ 40970001

ICD10 ³³ M86 M86.9

UMLS ⁷³ C0008707 C0029443

Sources

Summaries for Osteomyelitis

NIH Rare Diseases : ⁵³ Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to chronic recurrent multifocal osteomyelitis and mycobacterium fortuitum, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and bone marrow, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : ¹² A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : ⁷⁶ Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Sources

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)

#	Related Disease	Score	Top Affiliating Genes
1	chronic recurrent multifocal osteomyelitis	34.3	FBLIM1 IL1B LPIN2
2	mycobacterium fortuitum	32.3	CXCL8 IFNGR1
3	toxic shock syndrome	31.6	CXCL8 IFNG IL10 IL1B IL6 TNF
4	osteopetrosis, autosomal dominant 2	31.3	ACP5 CTSK TNFSF11
5	melioidosis	30.1	IFNG IL10 IL6 TNF
6	sporotrichosis	30.1	IFNG IL10
7	q fever	30.1	IFNG IL10 IL1B IL6 TNF
8	osteonecrosis	30.0	ACP5 BMP2 TNFSF11
9	endocarditis	30.0	CXCL8 IL10 IL6 TNF
10	synovitis	29.9	CXCL8 IL1B IL1RN IL6 TNF TNFSF11
11	arthritis	29.9	TNFSF11 TNF IL6 IL1RN IL1B IL1A
12	necrotizing fasciitis	29.9	CXCL8 IL1RN IL6
13	salmonellosis	29.9	IFNG IFNGR1 IL1B
14	pneumonia	29.8	CXCL8 IL10 IL1B IL6 TNF
15	fasciitis	29.8	CXCL8 IL6 TNF
16	neuritis	29.8	IFNG IL1B TNF
17	meningitis	29.8	CXCL8 IFNG IL10 IL1B IL6 TNF
18	typhoid fever	29.8	IFNG IFNGR1 IL1B IL6 TNF
19	rheumatic fever	29.8	IL10 IL6 TNF
20	interferon gamma, receptor 1, deficiency	29.8	IFNG IFNGR1
21	poliomyelitis	29.7	IFNG IL10 TNF
22	acute pyelonephritis	29.7	CXCL8 IL10 IL6
23	critical limb ischemia	29.7	IL6 TNF
24	paracoccidioidomycosis	29.7	IFNG IL10 IL6 TNF
25	myeloma, multiple	29.6	CXCL8 IL6 TNF TNFSF11
26	familial mediterranean fever	29.6	IL1B IL1RN TNF
27	extrapulmonary tuberculosis	29.6	IFNG IL10 IL1B
28	systemic lupus erythematosus	29.6	CXCL8 IFNG IL10 IL1B IL6 TNF
29	pyelonephritis	29.6	CXCL8 IL10 IL1B IL6 TNF
30	otitis media	29.6	CXCL8 IL10 IL1B IL6 TNF
31	arteries, anomalies of	29.6	IL1B IL6 TNF
32	peripheral nervous system disease	29.6	IL6 SPTLC1 TNF
33	sarcoidosis 1	29.6	IFNG IL1B TNF
34	acquired immunodeficiency syndrome	29.6	IFNG IL10 IL1B IL6 TNF
35	human immunodeficiency virus infectious disease	29.5	IFNG IL10 IL6 TNF
36	aspergillosis	29.5	IFNG IL10 TNF
37	reactive arthritis	29.5	IFNG IL10 TNF
38	ulcerative colitis	29.5	CXCL8 IFNG IL10 IL1B IL6 TNF
39	colitis	29.5	CXCL8 IFNG IL10 IL1B IL6 TNF
40	appendicitis	29.5	CXCL8 IL10 IL1B IL6 TNF
41	diabetes mellitus	29.5	IFNG IL1A IL1B IL1RN IL6 TNF
42	peritonitis	29.5	CXCL8 IL10 IL1B IL6 TNF
43	spondylitis	29.5	IL1RN IL6 TNF
44	bacterial sepsis	29.5	CXCL8 IL10 TNF
45	acute transverse myelitis	29.4	CXCL8 IL10 IL6
46	radiculopathy	29.4	CXCL8 IL1A IL6
47	adult-onset still's disease	29.4	IL1B IL1RN IL6 TNF
48	common variable immunodeficiency	29.4	IFNG IL10 IL6 TNF
49	joint disorders	29.4	IL1B IL1RN IL6 TNF TNFSF11
50	haemophilus influenzae	29.4	CXCL8 IL1B TNF

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Decubitus Ulcer
Deficiency Anemia	Heart Disease
Hypertension, Essential	Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:

Sources

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:

bone pain, pain in limb

MGI Mouse Phenotypes related to Osteomyelitis:

⁴⁶ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.33	ANO5 BMP2 CTSK IFNG IFNGR1 IL10
2	hematopoietic system	MP:0005397	10.32	BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
3	immune system	MP:0005387	10.28	BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
4	cardiovascular system	MP:0005385	10.25	BMP2 IFNG IFNGR1 IL10 IL1A IL1B
5	cellular	MP:0005384	10.24	ANO5 BMP2 CTSK FBLIM1 IFNG IFNGR1
6	growth/size/body region	MP:0005378	10.24	BMP2 CTSK IFNG IL10 IL1B IL1RN
7	mortality/aging	MP:0010768	10.15	BMP2 IFNG IFNGR1 IL10 IL1B IL1RN
8	craniofacial	MP:0005382	10.07	BMP2 CTSK IFNG IL10 IL1B TNF
9	integument	MP:0010771	10.06	IFNG IFNGR1 IL10 IL1A IL1B IL1RN
10	digestive/alimentary	MP:0005381	10.05	BMP2 CTSK IFNG IFNGR1 IL10 IL6
11	nervous system	MP:0003631	9.9	BMP2 CTSK IFNG IFNGR1 IL10 IL1B
12	muscle	MP:0005369	9.87	ANO5 IFNG IL10 IL6 PPP3CA TNF
13	neoplasm	MP:0002006	9.86	IFNG IFNGR1 IL10 IL1A IL1B IL6
14	reproductive system	MP:0005389	9.7	ANO5 BMP2 IFNG IFNGR1 IL10 IL1RN
15	skeleton	MP:0005390	9.36	BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10

Sources

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

leucovorin

Approved

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

58-05-9

6006 143

Trimethoprim

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

738-70-5

5578

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 2,Not Applicable,Early Phase 1

85721-33-1

2764

Sulfamethoxazole

Approved

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

723-46-6

5329

Vancomycin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

1404-90-6

14969 441141

Daptomycin

Approved, Investigational

Phase 4,Phase 3,Phase 2

103060-53-3

16129629

Doxycycline

Approved, Investigational, Vet_approved

Phase 4,Early Phase 1

564-25-0

54671203

Levofloxacin

Approved, Investigational

Phase 4,Early Phase 1

100986-85-4

149096

Linezolid

Approved, Investigational

Phase 4,Phase 3,Phase 2,Early Phase 1

165800-03-3

441401

Cefoxitin

Approved

Phase 4,Early Phase 1

35607-66-0

441199

Rifampicin

Approved

Phase 4,Early Phase 1

13292-46-1

5458213 5381226

Cefepime

Approved, Investigational

Phase 4,Phase 2,Early Phase 1

88040-23-7

5479537

Cefotaxime

Approved

Phase 4,Early Phase 1

63527-52-6

456256 5742673

Fusidic Acid

Approved, Investigational

Phase 4,Phase 2,Phase 3

6990-06-3

3000226

Ofloxacin

Approved

Phase 4,Early Phase 1

82419-36-1

4583

Ceftriaxone

Approved

Phase 4,Early Phase 1

73384-59-5

5479530 5361919

Nafcillin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Early Phase 1

985-16-0, 147-52-4

8982

Teicoplanin

Approved, Investigational

Phase 4,Phase 3,Phase 2

61036-62-2

Dalbavancin

Approved, Investigational

Phase 4,Phase 3,Phase 2

91097-81-3, 171500-79-1

122186

Clindamycin

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Early Phase 1

18323-44-9

29029

Cefazolin

Approved

Phase 4,Phase 3

25953-19-9

656510 33255

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

59-30-3

6037

Riboflavin

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4

83-88-5

493570

Gentamicins

Phase 4,Early Phase 1

Antiparasitic Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Vitamin B9

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Antiprotozoal Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Topoisomerase Inhibitors

Phase 4,Phase 2,Not Applicable,Early Phase 1

Vitamin B Complex

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Anti-Infective Agents, Urinary

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Folic Acid Antagonists

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Renal Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Antimalarials

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Antibiotics, Antitubercular

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Trimethoprim, Sulfamethoxazole Drug Combination

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Folate

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Cytochrome P-450 CYP1A2 Inhibitors

Phase 4,Phase 2,Not Applicable,Early Phase 1

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Immunoglobulins, Intravenous

Phase 4,Phase 3,Phase 2

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1

Antibodies

Phase 4,Phase 3,Phase 2

Immunoglobulins

Phase 4,Phase 3,Phase 2

Micronutrients

Phase 4,Phase 1

Trace Elements

Phase 4,Phase 1

methicillin

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 4,Early Phase 1

Cytochrome P-450 CYP3A Inducers

Phase 4,Early Phase 1

Antitubercular Agents

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 146)

#	Name	Status	NCT ID	Phase	Drugs
1	CERAMENT™\|G - Bone Healing and Re-infection Prophylaxis	Unknown status	NCT02128256	Phase 4
2	Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis	Completed	NCT02123628	Phase 4	duration of the antibiotic therapy
3	Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis	Completed	NCT00764114	Phase 4	antibiotic
4	Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects	Completed	NCT00634569	Phase 4
5	Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics	Recruiting	NCT03012529	Phase 4	Rifampin;Riboflavin Placebo
6	Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections	Recruiting	NCT03426761	Phase 4	Dalbavancin;Vancomycin
7	The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials	Recruiting	NCT03112356	Phase 4	99mTc-Leukoscan® scintigraphy
8	Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS)	Recruiting	NCT03261830	Phase 4	Cefazolin;Clindamycin;Saline
9	Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia	Recruiting	NCT02972983	Phase 4	Daptomycin
10	ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion	Enrolling by invitation	NCT02972593	Phase 4
11	Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients	Terminated	NCT01734694	Phase 4	Vancomycin;Ceftaroline;Daptomycin;Linezolid
12	Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures	Terminated	NCT02400112	Phase 4	Vancomycin
13	a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis	Withdrawn	NCT00578890	Phase 4
14	Ceftaroline in the Treatment of Bone and Joint Infections	Withdrawn	NCT02005068	Phase 4	Ceftaroline
15	Use of Santyl Within an Accountable Care Organization	Withdrawn	NCT02716519	Phase 4
16	Platelet Gel in Systemic Sclerosis	Unknown status	NCT00463125	Phase 2, Phase 3	Platelet Gel
17	Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID)	Unknown status	NCT01581593	Phase 3
18	Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)	Completed	NCT01922011	Phase 3	Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
19	Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis.	Completed	NCT00366249	Phase 3	Tigecycline;Ertapenem
20	Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers	Completed	NCT01586481	Phase 3
21	Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD)	Completed	NCT00538915	Phase 3
22	A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases	Completed	NCT01012323	Phase 3
23	Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections	Completed	NCT00423657	Phase 3	ceftaroline;vancomycin plus aztreonam;Placebo
24	Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections	Completed	NCT00424190	Phase 3	IV Vancomycin plus IV Aztreonam;Ceftaroline
25	Immune Globulin Subcutaenous (Human), 20%	Completed	NCT01412385	Phase 2, Phase 3
26	Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID)	Completed	NCT00719680	Phase 3
27	Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants	Completed	NCT01340469	Phase 3
28	Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy	Completed	NCT00419341	Phase 3
29	Gammagard Liquid and rHuPH20 in PID	Completed	NCT00814320	Phase 3
30	Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study)	Completed	NCT01461018	Phase 3
31	Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)	Completed	NCT00322556	Phase 3	Immunoglobulins Intravenous (Human)
32	Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)	Completed	NCT01370616	Phase 3	Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
33	Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy	Completed	NCT00542997	Phase 3
34	Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA"	Completed	NCT00729937	Phase 2, Phase 3	Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
35	Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study)	Completed	NCT01458171	Phase 3
36	Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study)	Completed	NCT00751621	Phase 3
37	Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)	Completed	NCT02066402	Phase 3	Tedizolid (BAY119-2631);Placebo Tedizolid (BAY119-2631);Linezolid;Placebo Linezolid
38	Staphylococcus Aureus Bacteremia Antibiotic Treatment Options	Recruiting	NCT01792804	Phase 3	Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
39	Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.	Recruiting	NCT03031210	Phase 2, Phase 3	Amoxicillin
40	Study of Octanorm Subcutaneous IG in Patients With PID	Recruiting	NCT01888484	Phase 3
41	Bronchiolitis in Infants Placebo Versus Dexamethasone Study	Recruiting	NCT03567473	Phase 3	Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
42	Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy	Active, not recruiting	NCT03174366	Phase 3	Denosumab
43	Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated	Active, not recruiting	NCT02569541	Phase 2, Phase 3	sodium fusidate
44	Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency	Not yet recruiting	NCT03492710	Phase 3
45	Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.	Terminated	NCT02202135	Phase 3	Ceftaroline fosamil;Vancomycin;Aztreonam
46	Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections	Terminated	NCT00108433	Phase 3	Cefazolin IV;Linezolid IV;Vancomycin (IV)
47	Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis	Withdrawn	NCT02344511	Phase 3	Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
48	Chronic Non-bacterial Osteomyelitis Treated With Pamidronate	Unknown status	NCT02594878	Phase 2	Pamidronatdinatrium
49	ASIS for Enbrel in Plaque Psoriasis	Unknown status	NCT02112097	Phase 1, Phase 2	Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
50	Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Participants With Osteomyelitis	Completed	NCT02685033	Phase 2	Dalbavancin;Comparator

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

ciprofloxacin

Cochrane evidence based reviews: osteomyelitis

Sources

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

#	Genetic test	Affiliating Genes
1	Osteomyelitis ²⁹

Sources

Anatomical Context for Osteomyelitis

MalaCards organs/tissues related to Osteomyelitis:

⁴¹

Bone, Testes, Bone Marrow, Skin, Spinal Cord, Lung, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

¹⁹

Bone Or

Sources

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 2521)

#	Title	Authors	Year
1	Evolution of chronic recurrent multifocal osteomyelitis in a child shown by MRI. ( 30364530 )	Gon?alves BPA...Silveira CRS	2019
2	<i>Mycobacterium kansasii</i> osteomyelitis - a masquerading disease. ( 29568531 )	Bhatt K....Banavathi K.	2018
3	Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report. ( 29443819 )	de Mesy Bentley K.L....Oh I.	2018
4	The role of whole-body magnetic resonance imaging in diagnosing chronic recurrent multifocal osteomyelitis. ( 29904495 )	Chen H.C....Nieves-Robbins N.M.	2018
5	The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29718410 )	Girschick H....Gattorno M.	2018
6	The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29596638 )	Girschick H....Gattorno M.	2018
7	Pyomyositis and osteomyelitis: an unusual cause of abdominal pain. ( 29559487 )	Fujiwara M....Araki T.	2018
8	Biologic treatment for chronic recurrent multifocal osteomyelitis: report of four cases and review of the literature. ( 29127574 )	Tronconi E....Pession A.	2018
9	A severe case of &lt;em&gt;Mycobacterium ulcerans&lt;/em&gt; (Buruli ulcer) osteomyelitis requiring a below-knee amputation. ( 29642809 )	Loftus M.J....Johnson P.D.	2018
10	Vancomycin incorporated chitosan/gelatin coatings coupled with TiO<sub>2</sub>-SrHAP surface modified cp-titanium for osteomyelitis treatment. ( 29395341 )	D N....N R.	2018
11	Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )	De LeA^n-BorrA!s R....Guiot H.M.	2018
12	Response to Dr. Jolobe: &quot;Optimising diagnostic strategies in emphysematous osteomyelitis&quot;. ( 29939346 )	Lopez Luis B.A....Ortiz-Brizuela E.	2018
13	Optimising diagnostic strategies in emphysematous osteomyelitis. ( 29939336 )	Jolobe O.M.P.	2018
14	Abscess originating from osteomyelitis as a cause of lower urinary tract symptoms (LUTS) and acute urinary retention. ( 29930185 )	Pimentel Torres J....Lima E.	2018
15	Chronic recurrent multifocal osteomyelitis in pediatrics: A diagnostic challenge. ( 29776891 )	Roig-Abraham N....MartA-nez-Morillo M.	2018
16	Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. ( 29124297 )	Berkowitz Y.J....Cassar-Pullicino V.N.	2018
17	Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity. ( 29425755 )	Chatelain S....Scolozzi P.	2018
18	Escherichia coli isolates from femoral bone marrow of broilers exhibit diverse pheno- and genotypic characteristics that do not correlate with macroscopic lesions of bacterial chondronecrosis with osteomyelitis (BCO). ( 29451003 )	GauA9mann B....Paudel S.	2018
19	In this issue - July 2018: Recommendations on equine PPIDa88A^a88Prevalence of alphaviruses in horses in North Queenslanda88A^a88Endoscopic transection of uterine tube bands in maresa88A^a88Radiography vs CT in osteomyelitis in foalsa88A^a88Transmission of BVDV to alpacasa88A^a88Dietary pH balance in cows with milk fever. ( 29944748 )	Jackson A.E.	2018
20	Osteomyelitis of the pubic symphysis after transrectal biopsies of the prostate. ( 29935934 )	Albers L.F....Roshani H.	2018
21	Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis. ( 29866071 )	Lang R....Wong A.	2018
22	Management of Pediatric Acute Hematogenous Osteomyelitis, Part I: Antimicrobial Stewardship Approach and Review of Therapies for Methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes, and Kingella kingae. ( 29920709 )	DeRonde K.J....Nicolau D.P.	2018
23	Genome Sequence of Staphylococcus aureus Ex1, Isolated from a Patient with Spinal Osteomyelitis. ( 29954915 )	Morcrette H....Studholme D.J.	2018
24	Dynamic contrast-enhanced magnetic resonance imaging for differentiating osteomyelitis from acute neuropathic arthropathy in the complicated diabetic foot. ( 29654348 )	Liao D....Li Y.	2018
25	Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )	Shirai T....Harigae H.	2018
26	Chronic non-suppurative mandibular osteomyelitis with proliferative periostitis: A review. ( 29435520 )	Taihi I....Radoi L.	2018
27	Bone inflammation and chronic recurrent multifocal osteomyelitis. ( 29565497 )	Chen Z....Feng G.	2018
28	Update on the genetics of nonbacterial osteomyelitis in humans. ( 29912021 )	Cox A.J....Ferguson P.J.	2018
29	Chronic Recurrent Multifocal Osteomyelitis of the Mandible: A Diagnostic Challenge. ( 29652766 )	Camison L....Losee J.E.	2018
30	Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products. ( 29391581 )	Niemann S....Kehrel B.E.	2018
31	Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )	Murillo O....Pallares R.	2018
32	Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical picture and radiography. ( 29844940 )	Konarzewska A....Studniarek M.	2018
33	Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis. ( 29403199 )	Vemu L....Chavali P.	2018
34	Mandibular Involvement in Recurrent Multifocal Osteomyelitis Associated with SAPHO Syndrome. ( 29387665 )	Hazboun I.M....Pfeilsticker L.N.	2018
35	Cranial Osteomyelitis: The Old Enemy Is Back. ( 29958369 )	Akhaddar A.	2018
36	Campylobacter jejuni vertebral osteomyelitis or tuberculosis: persisting diagnostic ambiguity - Authors' reply. ( 29412960 )	Puljiz I....Topic A.	2018
37	Beyond ulcers and osteomyelitis: imaging of less common musculoskeletal complications in diabetes mellitus. ( 29419313 )	Rao A....Gandikota G.	2018
38	Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )		2018
39	Lower-Extremity Osteomyelitis Treatment Using Calcium Sulfate/Hydroxyapatite Bone Void Filler with Antibiotics <sub>Seven-Year Retrospective Study</sub>. ( 29932757 )		2018
40	Comparison of conventional radiography and computed tomography as aids in the diagnosis of osteomyelitis in 11 foals. ( 29944745 )		2018
41	Chronic recurrent multifocal osteomyelitis: a case report. ( 29454377 )		2018
42	COULD OZONE TREATMENT BE A PROMISING ALTERNATIVE FOR OSTEOMYELITIS? AN EXPERIMENTAL STUDY. ( 29977149 )		2018
43	Medication-related osteonecrosis of the jaw, osteoradionecrosis, and osteomyelitis: A comparative histopathological study. ( 29723337 )		2018
44	A case of chronic granulomatous craniofacial osteomyelitis. ( 29942784 )		2018
45	Serum procollagen type 1 N propeptide: A novel diagnostic test for diabetic foot osteomyelitis - A case-control study. ( 29937901 )		2018
46	Going Bone Deep: Osseous Rosai-Dorfman Disease in an Adult with Recurrent, Culture-Negative Osteomyelitis. ( 29888015 )		2018
47	Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )		2018
48	Osteomyelitis in Cat-Scratch Disease: A Never-Ending Dilemma-A Case Report and Literature Review. ( 29808150 )		2018
49	Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder. ( 29425711 )		2018
50	Combined Labeled Leukocyte and Technicium 99 Sulfur Colloid Bone Marrow Imaging: Differentiating Primary Pyomyositis Pseudotumor from Osteomyelitis and Multiple Bone Infarcts. ( 29772988 )		2018

Sources

Genes for Osteomyelitis

Genes related to Osteomyelitis (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	42.21	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
2	LPIN2	Lipin 2	Protein Coding	32.3	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
3	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	29.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11865431 11139207 19880337
4	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	29.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11792597
5	CTSK	Cathepsin K	Protein Coding	24.65	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17032395
6	TNFSF11	TNF Superfamily Member 11	Protein Coding	24.06	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17032395
7	BMP2	Bone Morphogenetic Protein 2	Protein Coding	23.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17233287
8	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	23.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15872059
9	IL1B	Interleukin 1 Beta	Protein Coding	22.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL6	Interleukin 6	Protein Coding	22.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	TNF	Tumor Necrosis Factor	Protein Coding	22.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	FBLIM1	Filamin Binding LIM Protein 1	Protein Coding	22.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	ANO5	Anoctamin 5	Protein Coding	21.96	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
14	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	21.8	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
15	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	20.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	IFNG	Interferon Gamma	Protein Coding	20.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	IL1A	Interleukin 1 Alpha	Protein Coding	20.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	IL10	Interleukin 10	Protein Coding	20.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Osteomyelitis

Sources

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Sources

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.08	CTSK CXCL8 IFNG IFNGR1 IL10 IL1A
2	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.77	BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
3	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.6	BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.47	BMP2 CXCL8 IL10 IL1A IL1B IL6
5	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.47	CXCL8 IFNG IFNGR1 IL10 IL1A IL1B
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.37	BMP2 CXCL8 IL10 IL1A IL1B IL6
7	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	13.13	CTSK CXCL8 IFNG IFNGR1 IL10 IL1B
8	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	13.11	CXCL8 IFNGR1 IL1B IL6 PPP3CA TNF
9	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	13	CXCL8 IFNG IFNGR1 IL10 IL1A IL1B
10	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.91	CXCL8 IFNG IFNGR1 IL1A IL1B IL6
11	Pathways in cancer ³⁷	12.88	BMP2 CXCL8 IFNG IFNGR1 IL6
12	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ³⁷ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁷ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁵	12.82	CXCL8 IFNG IL1B IL6 TNF
13	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.76	BMP2 IL1A IL1B IL6 TNF
14	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.74	IFNG IFNGR1 IL1A IL1B TNF
15	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.72	IFNG IFNGR1 IL10 IL1A IL1B IL6
16	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.7	IFNG IFNGR1 IL10 PPP3CA TNF
17	NF-kappaB Signaling ⁴	12.7	IFNG IL10 IL1B IL1RN PPP3CA TNF
18	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.68	IL1A IL1B PPP3CA TNF TNFSF11
19	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.66	IFNG IL10 IL1B IL6 TNF
20	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.57	IFNG IL10 IL1A IL1B IL6 PPP3CA
21	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.54	IFNG IFNGR1 PPP3CA TNF
22	RANK Signaling in Osteoclasts ⁶⁴ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²² APRIL Pathway ⁶⁴ BAFF in B-Cell Signaling ⁶⁴ RANK Pathway ⁶⁴ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	12.5	ACP5 CTSK IL10 PPP3CA TNFSF11
23	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.46	CXCL8 IFNG IFNGR1 IL1A IL1B IL6
24	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.43	IFNG IFNGR1 IL10 IL6
25	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.43	CXCL8 IFNG IL1B IL6 TNF
26	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.41	IFNG IFNGR1 IL10 IL1A IL1B TNF
27	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.39	IFNG IL1B IL6 TNF
28	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.38	CXCL8 IL1A IL1B IL1RN IL6 TNF
29	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.36	BMP2 CXCL8 IFNG IL10 IL1A IL1B
30	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.33	CXCL8 IL1A IL6 TNF
31	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.33	CXCL8 IFNG IFNGR1 IL1B IL6 TNF
32	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.32	IL10 IL1B IL6 PPP3CA TNF
33	Necroptosis ³⁷ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.32	IFNG IFNGR1 IL1A IL1B TNF
34	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.28	CXCL8 IL10 IL1A IL1B IL1RN IL6
35	Colorectal Cancer Metastasis ⁶⁴	12.25	IFNG IFNGR1 IL6 TNF
36	Cellular senescence (KEGG) ³⁷	12.24	CXCL8 IL1A IL6 PPP3CA
37	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	12.22	IFNG IFNGR1 IL10 IL1B IL6 TNF
38	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.21	BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
39	Tuberculosis ³⁷	12.18	IFNG IFNGR1 IL10 IL1A IL1B IL6
40	Fluid shear stress and atherosclerosis ³⁷	12.17	IFNG IL1A IL1B TNF
41	Interleukin-4 and 13 signaling ⁶⁶	12.15	CXCL8 IL10 IL1A IL1B IL6 TNF
42	Adipogenesis ¹	12.14	BMP2 IL6 LPIN2 TNF
43	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	12.12	IFNG IL1B IL6 TNF
44	Senescence and Autophagy in Cancer ¹	12.1	BMP2 CXCL8 IFNG IL1A IL1B IL6
45	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.08	IFNG IL10 IL6 TNF
46	Spinal Cord Injury ¹	12.08	CXCL8 IFNG IL1A IL1B IL6 PPP3CA
47	AGE-RAGE signaling pathway in diabetic complications ³⁷	12.06	CXCL8 IL1A IL1B IL6 TNF
48	Amoebiasis ³⁷	12.04	CXCL8 IFNG IL10 IL1B IL6 TNF
49	Hematopoietic cell lineage ³⁷	11.99	IL1A IL1B IL6 TNF
50	NF-kappa B signaling pathway ³⁷	11.98	CXCL8 IL1B TNF TNFSF11

Sources

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	BMP2 CTSK CXCL8 IFNG IL10 IL1A
2	extracellular space	GO:0005615	9.36	BMP2 CTSK CXCL8 IFNG IL10 IL1A

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein phosphorylation	GO:0001934	9.97	BMP2 IFNG IL1B TNF
2	positive regulation of gene expression	GO:0010628	9.97	BMP2 IFNG IL1A IL1B IL6 PPP3CA
3	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.96	IL1B IL1RN TNF TNFSF11
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.93	IL1B IL6 TNF TNFSF11
5	cellular response to lipopolysaccharide	GO:0071222	9.91	CXCL8 IL10 IL1B IL1RN IL6 TNF
6	defense response to Gram-positive bacterium	GO:0050830	9.9	ACP5 IL6 TNF
7	ossification	GO:0001503	9.89	ACP5 BMP2 TNFSF11
8	calcium-mediated signaling	GO:0019722	9.88	CXCL8 PPP3CA TNFSF11
9	neutrophil chemotaxis	GO:0030593	9.88	CXCL8 IL1B IL1RN
10	cellular response to organic cyclic compound	GO:0071407	9.87	BMP2 IL1B TNF
11	positive regulation of JNK cascade	GO:0046330	9.87	IL1B IL1RN TNF TNFSF11
12	regulation of insulin secretion	GO:0050796	9.86	IFNG IL1B TNF
13	inflammatory response	GO:0006954	9.86	BMP2 CXCL8 IL10 IL1A IL1B IL1RN
14	humoral immune response	GO:0006959	9.85	IFNG IL6 TNF
15	interleukin-1-mediated signaling pathway	GO:0070498	9.83	IL1A IL1B IL1RN
16	positive regulation of interleukin-6 production	GO:0032755	9.83	IL1B IL1RN IL6 TNF
17	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.82	IFNG IL1B TNF
18	positive regulation of JUN kinase activity	GO:0043507	9.81	IL1B IL1RN TNF
19	immune response	GO:0006955	9.81	CXCL8 IFNG IL10 IL1A IL1B IL1RN
20	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.8	IL1A IL1B TNF
21	response to glucocorticoid	GO:0051384	9.8	IL10 IL1B IL1RN IL6 TNF
22	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.8	IL10 IL1B IL6 PPP3CA TNF TNFSF11
23	positive regulation of cytokine secretion	GO:0050715	9.79	IL10 IL1A TNF
24	negative regulation of neurogenesis	GO:0050768	9.77	IL1B IL6 TNF
25	bone resorption	GO:0045453	9.77	ACP5 CTSK TNFSF11
26	positive regulation of osteoclast differentiation	GO:0045672	9.76	IFNG TNF TNFSF11
27	positive regulation of glial cell proliferation	GO:0060252	9.73	IL1B IL6 TNF
28	negative regulation of growth of symbiont in host	GO:0044130	9.72	IL10 TNF
29	regulation of osteoclast differentiation	GO:0045670	9.72	TNF TNFSF11
30	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.72	IL1A IL1B
31	regulation of interferon-gamma-mediated signaling pathway	GO:0060334	9.72	IFNG IFNGR1
32	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.72	IFNG IL1B TNF
33	negative regulation of interleukin-12 production	GO:0032695	9.71	ACP5 IL10
34	positive regulation of astrocyte differentiation	GO:0048711	9.71	BMP2 IL1B
35	response to molecule of bacterial origin	GO:0002237	9.71	CXCL8 IL10
36	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.71	IL10 IL1B TNF
37	negative regulation of heterotypic cell-cell adhesion	GO:0034115	9.7	IL10 IL1RN
38	negative regulation of lipid storage	GO:0010888	9.7	IL6 TNF
39	endothelial cell apoptotic process	GO:0072577	9.69	IL10 TNF
40	positive regulation of chemokine biosynthetic process	GO:0045080	9.69	IL1B TNF
41	ectopic germ cell programmed cell death	GO:0035234	9.68	IL1A IL1B
42	negative regulation of glutamate secretion	GO:0014050	9.68	IL1B IL1RN
43	regulation of establishment of endothelial barrier	GO:1903140	9.68	IL1B TNF
44	negative regulation of cytokine secretion involved in immune response	GO:0002740	9.67	IL10 TNF
45	positive regulation of neuroinflammatory response	GO:0150078	9.67	IL1B IL6 TNF
46	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.65	IL1RN IL6
47	positive regulation of fever generation	GO:0031622	9.65	IL1B TNF
48	chronic inflammatory response to antigenic stimulus	GO:0002439	9.65	IL1B IL1RN TNF
49	sequestering of triglyceride	GO:0030730	9.64	IL1B TNF
50	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.63	IFNG IL1B TNF

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.32	BMP2 CXCL8 IFNG IL10 IL1A IL1B
2	interleukin-1 receptor binding	GO:0005149	9.13	IL1A IL1B IL1RN

Sources

Sources for Osteomyelitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Osteomyelitis

Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Classifications:

External Ids:

Summaries for Osteomyelitis

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Osteomyelitis:

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:

MGI Mouse Phenotypes related to Osteomyelitis:

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: osteomyelitis

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

Anatomical Context for Osteomyelitis

MalaCards organs/tissues related to Osteomyelitis:

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

Publications for Osteomyelitis

Articles related to Osteomyelitis:

Genes for Osteomyelitis

Genes related to Osteomyelitis (0 elite genes):

Variations for Osteomyelitis

Expression for Osteomyelitis

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

Sources for Osteomyelitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :