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MCID: OST017
MIFTS: 63

Osteomyelitis

Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Osteomyelitis

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MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 73 20 29 54 15 17 70 32

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1019
ICD9CM 34 730.1
SNOMED-CT 67 203181001
ICD10 32 M86 M86.9
UMLS 70 C0008707 C0029443
Sources

Summaries for Osteomyelitis

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GARD : 20 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to sapho syndrome and chronic recurrent multifocal osteomyelitis, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fusidic Acid and Cefepime have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 73 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Sources

Related Diseases for Osteomyelitis

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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1369)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 32.4 LPIN2 FBLIM1 CXCL8
2 chronic recurrent multifocal osteomyelitis 32.1 TNFSF11 TNF NLRP3 LPIN2 IL6 IL1RN
3 mycobacterium fortuitum 32.0 IFNGR1 CXCL8
4 petrositis 31.9 IFNG CRP
5 osteopetrosis 31.7 TNFSF11 TNF IFNG CTSK ACP5
6 chronic granulomatous disease 31.7 TNF IL1B IFNG CXCL8 CASP1
7 septic arthritis 31.6 TNF PPP3CA IFNG CXCL8 CRP
8 toxic shock syndrome 31.4 TNF IL6 IL1RN IL1B IL10 IFNG
9 periostitis 31.3 LPIN2 IL1RN CRP
10 cellulitis 31.2 TNFSF11 TNF IL6 CRP
11 osteonecrosis 31.0 TNFSF11 TNF IL1B BMP2 ACP5
12 haemophilus influenzae 31.0 TNF CXCL8
13 infective endocarditis 31.0 TNF IL6 CRP
14 acne 31.0 TNF IL6 IL1RN IL1B IL1A CXCL8
15 endocarditis 30.9 TNF IL6 IL1A IL10 IFNG CXCL8
16 cryptococcosis 30.9 TNF IL10 IFNG
17 melioidosis 30.9 TNF IL6 IL10 IFNG
18 actinomycosis 30.9 TNF IL6 IL1B IL10 CRP
19 sickle cell anemia 30.9 TNF IL6 IL1B IL10 CXCL8 CRP
20 invasive aspergillosis 30.8 IL10 IFNG CXCL8
21 skeletal tuberculosis 30.8 TNF IFNG CRP
22 fasciitis 30.8 TNF IL6 IL1RN IFNG CXCL8
23 tenosynovitis 30.8 TNF IL6 IL1B CRP
24 spinal cord injury 30.8 TNF IL6 CXCL8
25 pyoderma gangrenosum 30.8 TNF NLRP3 CXCL8
26 prosthetic joint infection 30.8 IL6 IL1B CRP
27 mycobacterium tuberculosis 1 30.8 TNF IL10 IFNGR1 IFNG
28 disease by infectious agent 30.8 TNF IL6 IL1RN IL1B IL10 IFNGR1
29 myositis 30.7 TNF IL6 IL1B IL1A IFNG CXCL8
30 q fever 30.7 TNF IL6 IL1B IL10 IFNG
31 vascular disease 30.7 TNF IL6 IL1A IL10 IFNG CRP
32 bursitis 30.7 TNF IL6 IL1B CRP
33 mycobacterium abscessus 30.7 TNF NLRP3 CXCL8
34 chickenpox 30.7 TNF IL6 IL10 IFNG CRP
35 aspergillosis 30.7 TNF IL6 IL1B IL1A IL10 IFNG
36 smallpox 30.7 TNF IL1RN IL1B IFNG
37 decubitus ulcer 30.7 TNF IL6 IL1B IL1A CRP
38 ankylosis 30.7 TNFSF11 TNF BMP2
39 spondylitis 30.7 TNFSF11 TNF IL6 IL1B IL10 IFNG
40 compartment syndrome 30.7 TNF IL6 CRP
41 syphilis 30.6 TNF IL6 IFNG CRP
42 nocardiosis 30.6 TNF IFNG CRP
43 necrotizing fasciitis 30.6 IL6 IL1RN IL1B CXCL8 CRP
44 mycobacterium kansasii 30.6 NLRP3 CXCL8
45 chronic ulcer of skin 30.6 TNF IL6 IL1B CRP
46 lung abscess 30.6 TNF IL6 IFNG CRP
47 pycnodysostosis 30.6 TNFSF11 CTSK ACP5
48 myelitis 30.5 TNF IL6 IL10 CXCL8
49 enterocolitis 30.5 TNF IL6 IL10 CXCL8
50 pyoderma 30.5 TNF NLRP3 IL1B CXCL8 CRP

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis
Sources

Symptoms & Phenotypes for Osteomyelitis

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UMLS symptoms related to Osteomyelitis:


bone pain; pain in limb

GenomeRNAi Phenotypes related to Osteomyelitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CXCL8 IL10 IL1A IL1B NLRP3 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 CXCL8 IL10 IL1B NLRP3 TNF

MGI Mouse Phenotypes related to Osteomyelitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 BMP2 CASP1 CRP CTSK IFNG IFNGR1
2 hematopoietic system MP:0005397 10.38 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
3 growth/size/body region MP:0005378 10.37 BMP2 CASP1 CTSK FBLIM1 IFNG IL10
4 immune system MP:0005387 10.36 BMP2 CASP1 CRP CTSK FBLIM1 IFNG
5 cardiovascular system MP:0005385 10.3 BMP2 CASP1 CRP IFNG IFNGR1 IL10
6 mortality/aging MP:0010768 10.17 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
7 digestive/alimentary MP:0005381 10.16 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
8 integument MP:0010771 10.14 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
9 nervous system MP:0003631 9.97 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
10 limbs/digits/tail MP:0005371 9.91 BMP2 CTSK FBLIM1 IL10 NLRP3 TNF
11 neoplasm MP:0002006 9.91 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
12 reproductive system MP:0005389 9.77 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
13 skeleton MP:0005390 9.4 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
Sources

Drugs & Therapeutics for Osteomyelitis

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Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 234)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fusidic Acid Approved, Investigational Phase 4 6990-06-3 3000226
2
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
5
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
6
Sulfamethoxazole Approved Phase 4 723-46-6 5329
7
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
8
Ofloxacin Approved Phase 4 82419-36-1 4583
9
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
10
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
11
Vancomycin Approved Phase 4 1404-90-6 441141 14969
12
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
14
Nafcillin Approved, Investigational Phase 4 147-52-4, 985-16-0 8982
15
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
16
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
17
Dicloxacillin Approved, Investigational, Vet_approved Phase 4 3116-76-5 18381
18
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
19
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
20
Cefazolin Approved Phase 4 25953-19-9 656510 33255
21
Clonidine Approved Phase 4 4205-90-7 2803
22
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
23
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
24
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
25
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
26 Folic Acid Antagonists Phase 4
27 Antiparasitic Agents Phase 4
28 Antiprotozoal Agents Phase 4
29 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
30 Antimalarials Phase 4
31 Cytochrome P-450 Enzyme Inhibitors Phase 4
32 Vitamin B9 Phase 4
33 Folate Phase 4
34 Vitamin B Complex Phase 4
35 beta-Lactamase Inhibitors Phase 4
36 Coagulase Phase 4
37 Amoxicillin-Potassium Clavulanate Combination Phase 4
38 Clavulanic Acids Phase 4
39 Antitubercular Agents Phase 4
40 Dermatologic Agents Phase 4
41 Micronutrients Phase 4
42 Trace Elements Phase 4
43 Nutrients Phase 4
44 Photosensitizing Agents Phase 4
45 Vitamins Phase 4
46 Vitamin B2 Phase 4
47 Pharmaceutical Solutions Phase 4
48 Analgesics Phase 4
49 Adrenergic alpha-Agonists Phase 4
50 Adrenergic Agonists Phase 4

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 CERAMENTâ„¢|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
3 Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study Completed NCT02123628 Phase 4 duration of the antibiotic therapy
4 CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
5 Oral-only Antibiotics for Bone and Joint Infections in Children - A Nationwide Randomized Controlled Trial Recruiting NCT04563325 Phase 4 Oral co-amoxiclav or oral dicloxacillin only;IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
6 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
7 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
8 Clonidine for Tourniquet-related Pain in Children: A Pilot Study Not yet recruiting NCT04564430 Phase 4 Catapresan
9 BonE and Joint Infections - Simplifying Treatment in Children Trial Not yet recruiting NCT04538053 Phase 4 Oral cefalexin only;IV cefazolin followed by oral cefalexin
10 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
11 Comparison of Medical and Medical-surgical Management of Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
12 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
13 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
14 A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline Versus Ertapenem for the Treatment of Foot Infections in Subjects With Diabetes Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
15 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
16 A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to Gram-Positive Organisms Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
17 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
18 A Phase 2, Single-center, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-Positive Organisms Completed NCT02685033 Phase 2 Dalbavancin;Comparator
19 Phase 1/2 Trial of Ceftaroline for the Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Completed NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
20 A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthetic Hip or Knee Joint Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
21 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
22 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Active, not recruiting NCT03009045 Phase 2 Tedizolid
23 The Use of Antimicrobial Synthetic Bone Grafts in the Treatment of Bone Infection Active, not recruiting NCT03945864 Phase 1, Phase 2
24 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) Terminated NCT02168816 Phase 2 Intravenous Antibacterial Agent;Oral Antibacterial Agent
25 A Phase 2, Multicenter, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-positive Organisms Terminated NCT03091439 Phase 2 Dalbavancin;Standard of Care
26 Exploration of the Use of [124I]FIAU Positron Emission Tomography-Computed Tomography Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection. Terminated NCT01764919 Phase 2
27 A Prospective, Non-Randomized, Open-Label Study on the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
28 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
29 Correlation Between Middle Turbinate Histopathology and Computed Tomography Staging in Chronic Rhinosinusitis Unknown status NCT00899561
30 Sensitivity, Specificity and Predictive Value of High Resolution (B-Mode) Ultrasonography (HRUS) for the Detection of Osteomyelitis in Chronic Wound Patients Unknown status NCT02198755
31 Prospective Randomized Clinical Trial Comparing Efficacy Surgical Versus Medical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903 Ciprofloxacin;Amoxicillin-Potassium Clavulanate Combination;Sulfamethoxazole trimethoprim
32 A Prospective, Randomized Trial Comparing Vancomycin With Trimethoprim/Sulfamethoxazole for the Treatment of MRSA Osteomyelitis Unknown status NCT00324922 trimethoprim-sulfamethoxazole;vancomycin
33 Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics Unknown status NCT02099240 Early Phase 1 oral antibiotics
34 Assessment of White Blood Cell SPECT/CT in Monitoring Antibiotic Treatment in Patients With Diabetic Foot Osteomyelitis Unknown status NCT02927678
35 Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis Unknown status NCT01473979
36 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
37 Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection Completed NCT03808285
38 Can we Improve the Treatment of Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures by Using Perioperative Immunoinflammatory Markers? Completed NCT03459261
39 Randomized Study Comparing Different Durations of Antibiotic Treatment for Diabetic Foot Infections Completed NCT03615807 Antibiotic duration
40 Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis Completed NCT01125839
41 Acinetobacter Baumannii-related Osteomyelitis: Clinical and Epidemiological Characterization Completed NCT03559530 Antimicrobial
42 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Completed NCT02165579
43 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Completed NCT02308774
44 Pilot Evaluation of PCR Multiplex Tests for a Rapid Diagnosis of Bone Infections in Diabetic Foot Completed NCT03434288
45 Risk Factors Associated With Recurrence and Life-threatening Complications for Patients Hospitalized With Chronic Suppurative Osteomyelitis of the Jaw Completed NCT01670422
46 LOOP- Long- and Midterm Outcomes of Osteoarticular Infections in Paediatric Patients. Completed NCT03827980
47 Studying on the Difference Between Foot Osteomyelitis Patients With or Without Diabetes Completed NCT04240964
48 Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections Completed NCT02311452
49 SPONDIMMO : Multicentered Descriptive Prospective Study of Immobilization and Neurological Complication in Patients With Vertebral Osteomyelitis. Completed NCT04655950
50 Drug Delivery Devices for Osteomyelitis Completed NCT02968693 Vancomycin

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ciprofloxacin
Sources

Genetic Tests for Osteomyelitis

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Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis (disease) 29
Sources

Anatomical Context for Osteomyelitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

19
Bone, Bone Marrow

MalaCards organs/tissues related to Osteomyelitis:

40
Bone, Skin, Bone Marrow, Spinal Cord, Heart, Kidney, Prostate
Sources

Publications for Osteomyelitis

About this section

Articles related to Osteomyelitis:

(show top 50) (show all 23025)
# Title Authors PMID Year
1
Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency. 61 54
19880337 2010
2
Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein-2 for vertebral osteomyelitis. 61 54
17233287 2007
3
RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. 54 61
17032395 2006
4
Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. 54 61
15872059 2005
5
[The study of the antioxidant enzymes in erythrocytes in lung diseases]. 54 61
12838770 2003
6
Genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. 61 54
11865431 2002
7
Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. 54 61
11792597 2002
8
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. 54 61
11139207 2001
9
Antimicrobial treatment of chronic osteomyelitis. 54 61
10101310 1999
10
Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. 54 61
9581562 1997
11
The effect of growth temperature on Staphylococcus aureus binding to type I collagen. 54 61
7715422 1994
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 61 54
8382334 1993
13
Medium-term outcomes of multi-disciplinary surgical management of non-ischemic diabetic heel ulcers. 61
33717969 2021
14
The current burden of diabetic foot disease. 61
33680841 2021
15
Conservative surgery for chronic diabetic foot osteomyelitis: Procedures and recommendations. 61
33680830 2021
16
One-stage debridement and bone transport versus first-stage debridement and second-stage bone transport for the management of lower limb post-traumatic osteomyelitis. 61
33659183 2021
17
Bladder neck necrosis resulting in fistulae to rectum and bilateral thighs post radical prostatectomy and salvage radiotherapy. 61
33665122 2021
18
Direct admission versus transfer to a tertiary hospital for definitive management of lower extremity injuries: Systematic review and meta-analysis. 61
33740786 2021
19
Impact of the COVID-19 Epidemic on hospitalization for diabetic foot ulcers during lockdown: A French nationwide population-based study. 61
33797791 2021
20
Morbidity and Mortality of Spinal Epidural Abscess in End-Stage Renal Disease Patients: A Case-Control Study. 61
33637307 2021
21
Unusual Osteoblastoma of the First Metatarsal Bone Treated by Total Resection and Fibular Autograft: A Case Report. 61
33798119 2021
22
Reconstruction using a free vascularised medial femoral condyle corticoperiosteal flap for osteomyelitis of the juxta-articular distal radius: A case report and literature review. 61
33665305 2021
23
Q fever vertebral osteomyelitis among adults: a case series and literature review. 61
33475036 2021
24
Chronic Q fever vertebral osteomyelitis, an underrecognized clinical entity. 61
33475041 2021
25
Pain for Greater Than 4 Days Is Highly Predictive of Concomitant Osteomyelitis in Children With Septic Arthritis. 61
33577239 2021
26
A Pediatric Case of Gingival Swelling and Chilblains as Previously Unrecognized Manifestations of Chronic Nonbacterial Osteomyelitis. 61
31972737 2021
27
Surgical management of garre's osteomyelitis in an 8-year-old child. 61
33642412 2021
28
The management of concomitant septic arthritis of the knee and femoral osteomyelitis - A case series and literature review. 61
33665307 2021
29
Bone single-photon emission computed tomography-CT peak standardized uptake value for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw. 61
33180378 2021
30
Diagnostic Accuracy of Bone Culture Versus Biopsy in Diabetic Foot Osteomyelitis. 61
33739950 2021
31
Polymicrobial Skull Base Osteomyelitis Related to Chronic Sphenoiditis and Endoscopic Sinus Surgery. 61
32990341 2021
32
Clinical characteristics of pediatric synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the first Chinese case series from a single center. 61
32929648 2021
33
Early-Phase SPECT/CT for Diagnosing Osteomyelitis: A Retrospective Pilot Study. 61
33289359 2021
34
Role or oritavancin and dalbavancin in acute bacterial skin and skin structure infections and other potential indications. 61
33405480 2021
35
The impact of gender on the clinical presentation, management, and surgical outcomes of patients with native-joint septic arthritis. 61
32613746 2021
36
Clear Cell Change in Reactive Angiogenesis: A Potential Diagnostic Pitfall. 61
33002917 2021
37
Euphorbia helioscopia L.: A phytochemical and pharmacological overview. 61
33440297 2021
38
Compared outcomes of femoral shaft fracture treatment in school-age children in Sub-Saharan Africa: Primary open reduction and intramedullary K-wire fixation versus traction followed by spica cast. 61
33642403 2021
39
From a plant secretion to the promising bone grafts: Cryogels of silicon-integrated quince seed mucilage by microwave-assisted sol-gel reaction. 61
33454223 2021
40
Medications for Opioid use Disorder Associated With Less Against Medical Advice Discharge Among Persons Who Inject Drugs Hospitalized With an Invasive Infection. 61
32804690 2021
41
A single K-wire to prevent poor outcomes in closed soft-tissue mallet finger management due to patient non-compliance. 61
33517533 2021
42
Long-term outcome of persons with diabetic and non-diabetic neuro-osteoarthropathy after foot correction using external fixation. 61
32949070 2021
43
Long-term results after internal partial forefoot amputation (resection): a retrospective analysis. 61
32266517 2021
44
Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma. 61
33806515 2021
45
Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis. 61
33778997 2021
46
Large exudative retinal detachment with choroidal granuloma unmasking disseminated tuberculosis: imaging and management. 61
33789862 2021
47
Paradoxical Psoriasis in Children Receiving Anti-TNFα Treatment for Inflammatory/autoimmune Disease. 61
33761130 2021
48
[Acute haematogenous osteomyelitis in Lisbon: An unexpectedly high association with myositis and arthritis]. 61
33674248 2021
49
Whole-body magnetic resonance imaging in inflammatory diseases: Where are we now? Results of an International Survey by the European Society of Musculoskeletal Radiology. 61
33454461 2021
50
Transmetatarsal Amputation Outcomes When Utilized to Address Foot Gangrene and Infection: A Retrospective Chart Review. 61
33218867 2021
Sources

Variations for Osteomyelitis

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Expression for Osteomyelitis

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Search GEO for disease gene expression data for Osteomyelitis.
Sources

Pathways for Osteomyelitis

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Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.13 TNFSF11 TNF PPP3CA NLRP3 IL6 IL1RN
2
ERK Signaling 63
Show member pathways
 13.89 TNFSF11 TNF IL6 IL1B IL1A IL10
3
PEDF Induced Signaling 63
Show member pathways
 13.79 TNFSF11 TNF PPP3CA IL6 IL1RN IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.62 TNF IL6 IL1B IL1A IL10 IFNGR1
5
Akt Signaling 63
Show member pathways
 13.49 TNFSF11 TNF IL6 IL1B IL1A IL10
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.48 TNFSF11 TNF IL6 IL1RN IL1B IL1A
7
PAK Pathway 63
Show member pathways
 13.42 TNFSF11 TNF IL6 IL1B IL1A IL10
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.27 TNF PPP3CA NLRP3 IL6 IL1B IL10
9
Human cytomegalovirus infection 36
Show member pathways
 13.02 TNF PPP3CA IL6 IL1B IFNGR1 CXCL8
10
Allograft rejection 36 1
Show member pathways
 12.98 TNF IL6 IL1B IL1A IL10 IFNG
11
Measles 36
Show member pathways
 12.93 TNF NLRP3 IL6 IL1B IL1A IFNGR1
12
IL-2 Pathway 63
Show member pathways
 12.88 TNF PPP3CA IL1B IL1A IFNGR1 IFNG
13
Herpes simplex virus 1 infection 36
12.86 TNF IL6 IL1B IFNGR1 IFNG
14
Salmonella infection (KEGG) 36
Show member pathways
 12.84 TNF NLRP3 IL6 IL1B CXCL8 CASP1
15
MAPK signaling pathway 36 1
12.83 TNF PPP3CA IL1B IL1A CASP1
16
NF-KappaB Family Pathway 63
Show member pathways
 12.78 TNF IL6 IL1B IL1A BMP2
17
T cell receptor signaling pathway 36
Show member pathways
 12.75 TNF PPP3CA IL6 IL1B IL1A IL10
18
4-1BB Pathway 63
Show member pathways
 12.74 TNF IL1B IL1A IFNGR1 IFNG
19
Th17 cell differentiation 36
Show member pathways
 12.74 TNF PPP3CA IL6 IL1B IL1A IL10
20
NF-kappaB Signaling 4
12.72 TNFSF11 TNF PPP3CA IL1RN IL1B IL10
21
Immune response NFAT in immune response 23
Show member pathways
 12.71 TNF PPP3CA IL10 IFNGR1 IFNG
22
TRAF Pathway 63
Show member pathways
 12.71 TNFSF11 TNF PPP3CA IL1B IL1A CASP1
23
Immune response IL-23 signaling pathway 23
Show member pathways
 12.67 TNF IL6 IL1B IL10 IFNG
24
RANK Signaling in Osteoclasts 63
Show member pathways
 12.6 TNFSF11 TNF PPP3CA IL1B IL1A IL10
25
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.57 TNF NLRP3 IL6 IL1B CXCL8 CASP1
26
Shigellosis 36
12.51 TNF NLRP3 IL1B CXCL8 CASP1
27
Toll Comparative Pathway 63
Show member pathways
 12.48 TNF IL6 IL1B IL1A IFNGR1 IFNG
28
JAK-STAT signaling pathway 36
Show member pathways
 12.47 IL6 IL10 IFNGR1 IFNG
29
Selenium Micronutrient Network 1
Show member pathways
 12.44 TNF IL6 IL1B IFNG CRP
30
IL-17 Family Signaling Pathways 64
Show member pathways
 12.44 TNF IL6 IL1B IFNG CXCL8
31
Toxoplasmosis 36
Show member pathways
 12.43 TNF IL1B IL1A IL10 IFNGR1 IFNG
32
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.4 TNF IL6 IL10 CXCL8
33
NOD-like receptor signaling pathway 36
12.4 TNF NLRP3 IL6 IL1B CXCL8 CASP1
34
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.4 TNF IL6 IL1B IL1A IL10 IFNG
35
IL-1 Family Signaling Pathways 64
Show member pathways
 12.39 TNF IL6 IL1RN IL1B IL1A CXCL8
36
IL-1 signaling pathway 1
Show member pathways
 12.37 IL1RN IL1B IL1A CASP1
37
Bacterial infections in CF airways 23
Show member pathways
 12.35 TNF IL6 IL1B IFNGR1 IFNG CXCL8
38
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.34 TNF IL6 IL1A CXCL8
39
C-type lectin receptor signaling pathway 36
Show member pathways
 12.34 TNF PPP3CA NLRP3 IL6 IL1B IL10
40
Necroptosis 36
Show member pathways
 12.32 TNF NLRP3 IL1B IL1A IFNGR1 IFNG
41
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.28 TNF IL6 IL1RN IL1B IL1A IL10
42
Colorectal Cancer Metastasis 63
12.27 TNF IL6 IFNGR1 IFNG
43
Cellular senescence (KEGG) 36
12.24 PPP3CA IL6 IL1A CXCL8
44
Tuberculosis 36
12.23 TNF PPP3CA IL6 IL1B IL1A IL10
45
Fluid shear stress and atherosclerosis 36
12.18 TNF IL1B IL1A IFNG
46
Yersinia infection 36
12.18 TNF NLRP3 IL6 IL1B IL10 CXCL8
47
Interleukin-4 and 13 signaling 65
12.16 TNF IL6 IL1B IL1A IL10 CXCL8
48
Adipogenesis 1
12.15 TNF LPIN2 IL6 BMP2
49
Senescence and Autophagy in Cancer 1
12.12 IL6 IL1B IL1A IFNG CXCL8 BMP2
50
Amoebiasis 36
12.1 TNF IL6 IL1B IL10 IFNG CXCL8
Sources

GO Terms for Osteomyelitis

About this section

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 extracellular region GO:0005576 9.47 TNFSF11 TNF NLRP3 IL6 IL1RN IL1B
3 NLRP3 inflammasome complex GO:0072559 9.16 NLRP3 CASP1

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 TNFSF11 TNF PPP3CA NLRP3 LPIN2 IL6
2 negative regulation of cell proliferation GO:0008285 10.1 IL6 IL1B IL1A IL10 CXCL8 BMP2
3 negative regulation of gene expression GO:0010629 10.07 TNF PPP3CA IFNG CXCL8 BMP2
4 positive regulation of protein phosphorylation GO:0001934 10.01 TNF IL1B IFNG BMP2
5 inflammatory response GO:0006954 9.97 TNF NLRP3 IL6 IL1RN IL1B IL1A
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNFSF11 TNF NLRP3 IL6 IL1B
7 immune response GO:0006955 9.96 TNFSF11 TNF IL6 IL1RN IL1B IL1A
8 positive regulation of tumor necrosis factor production GO:0032760 9.92 IL6 IL1A IFNGR1 IFNG
9 regulation of insulin secretion GO:0050796 9.9 TNF IL6 IL1B IFNG
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 TNF IL6 IFNG
11 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B BMP2
12 positive regulation of interleukin-8 production GO:0032757 9.88 TNF IL6 IL1B
13 humoral immune response GO:0006959 9.88 TNF IL6 IFNG
14 positive regulation of interleukin-6 production GO:0032755 9.88 TNF IL6 IL1B IL1A IFNG
15 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.87 TNF NLRP3 CASP1
16 positive regulation of phagocytosis GO:0050766 9.87 TNF IL1B IFNG
17 positive regulation of epithelial to mesenchymal transition GO:0010718 9.87 IL6 IL1B BMP2
18 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL1RN IL10
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 TNF IL1B IFNG
20 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.85 TNF IL10 BMP2
21 positive regulation of chemokine production GO:0032722 9.85 TNF IL6 IFNG
22 acute-phase response GO:0006953 9.85 IL6 IL1RN CRP
23 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNFSF11 TNF PPP3CA IL6 IL1B IL10
24 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.84 TNF IL1B IL1A
25 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10
26 microglial cell activation GO:0001774 9.83 TNF IFNGR1 IFNG
27 positive regulation of vascular endothelial growth factor production GO:0010575 9.83 IL6 IL1B IL1A
28 positive regulation of interleukin-1 beta production GO:0032731 9.83 TNF NLRP3 IL6 IFNG CASP1
29 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
30 bone resorption GO:0045453 9.81 TNFSF11 CTSK ACP5
31 positive regulation of osteoclast differentiation GO:0045672 9.8 TNFSF11 TNF IFNG
32 positive regulation of cytokine production GO:0001819 9.8 TNF IL1A IL10 IFNG CASP1
33 positive regulation of amyloid-beta formation GO:1902004 9.79 TNF IFNGR1 IFNG
34 positive regulation of glial cell proliferation GO:0060252 9.78 TNF IL6 IL1B
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 TNF IL1B IFNG
36 astrocyte activation GO:0048143 9.76 TNF IFNGR1 IFNG
37 cellular response to lipopolysaccharide GO:0071222 9.76 TNF NLRP3 IL6 IL1B IL1A IL10
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 TNF IL1B IL10
39 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.73 TNF PPP3CA
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IL10 IFNG
41 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL1RN IL10
42 response to molecule of bacterial origin GO:0002237 9.72 IL10 CXCL8
43 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
44 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6 IL1B
45 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
46 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.71 IL6 IL1RN
47 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.71 NLRP3 IL6
48 negative regulation of amyloid-beta clearance GO:1900222 9.71 TNF IFNGR1 IFNG
49 negative regulation of cytokine production involved in immune response GO:0002719 9.7 TNF IL10
50 positive regulation of fever generation GO:0031622 9.7 TNF IL1B

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Osteomyelitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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