MCID: OST017
MIFTS: 63

Osteomyelitis

Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases
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Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 11 19 75 28 53 43 14 16 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:1019
ICD9CM 34 730.1
MeSH 43 D010019
SNOMED-CT 68 203181001
ICD10 31 M86 M86.9
UMLS 71 C0008707 C0029443

Summaries for Osteomyelitis

GARD: 19 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system.

MalaCards based summary: Osteomyelitis is related to sapho syndrome and chronic recurrent multifocal osteomyelitis, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clonidine and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Disease Ontology: 11 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia: 75 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1588)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 32.2 TNF LPIN2 IL1RN FBLIM1 CXCL8 CRP
2 chronic recurrent multifocal osteomyelitis 32.0 TNFSF11 TNF NLRP3 LPIN2 IL6 IL1RN
3 osteopetrosis 31.7 TNFSF11 TNF IFNG CTSK ACP5
4 osteopetrosis, autosomal dominant 2 31.7 TNFSF11 CTSK ACP5
5 serum amyloid a amyloidosis 31.5 TNF NLRP3 IL6 CRP
6 septic arthritis 31.5 TNFSF11 TNF TLR2 PPP3CA IL6 IL1B
7 epidural abscess 31.3 IFNG CRP
8 osteonecrosis 31.2 IL10 BMP2 ACP5
9 toxic shock syndrome 31.1 TNF TLR2 IL6 IL1RN IL1B IL1A
10 actinomycosis 31.1 TNF IL10 CRP
11 cryptococcosis 31.1 TNF IL10 IFNG
12 cellulitis 31.0 TNFSF11 TNF IL6 IL1B CXCL8 CRP
13 haemophilus influenzae 31.0 TNF TLR2 IL1B CXCL8
14 peripheral vascular disease 31.0 TNF IL6 IL1B CRP
15 infective endocarditis 31.0 PPP3CA IL6 CXCL8 CRP
16 myositis 31.0 TNF IL6 IL1B IL1A IFNG
17 back pain 31.0 IL6 IL1RN IL1B IL10 CXCL8 CRP
18 macs syndrome 31.0 TNF IL10 IFNGR1 IFNG
19 periostitis 30.9 TNF LPIN2 IL1RN IL1B IL1A CRP
20 aspergillosis 30.9 TNF TLR2 IL6 IL1RN IL1B IL1A
21 fasciitis 30.9 TNF IL6 IL1RN IFNG CXCL8
22 mucormycosis 30.9 TNF IL6 IL10 IFNG CRP
23 bone disease 30.9 TNFSF11 TNF IL6 CTSK BMP2 ACP5
24 skeletal tuberculosis 30.8 IFNG CRP
25 melioidosis 30.8 TNF TLR2 IL6 IL10 IFNG
26 decubitus ulcer 30.8 TNF IL6 IL1B IL10 CXCL8 CRP
27 deficiency anemia 30.8 TNF IL6 IL1B IL10 CRP
28 endocarditis 30.8 TNF TLR2 IL6 IL1A IL10 IFNG
29 tenosynovitis 30.7 TNF IL6 IL1B CRP
30 pustulosis of palm and sole 30.7 TNF LPIN2 IL1RN CXCL8 CRP
31 blastomycosis 30.7 TNF IL6 CRP
32 spondylitis 30.7 TNFSF11 TNF IL6 IL1B IL10 IFNG
33 mycobacterium chelonae 30.7 TLR2 CXCL8
34 inflammatory bowel disease 1 30.7 TNF TLR2 IL6 IL1B IL10
35 alcohol use disorder 30.7 TNF IL6 IL1B CRP
36 smallpox 30.7 TNF IL1RN IL1B IFNG
37 bursitis 30.7 TNF IL6 IL1B CRP
38 compartment syndrome 30.6 TNF IL6 CRP
39 bell's palsy 30.6 TNF IL6 CRP
40 adult syndrome 30.6 TNF IL6 CRP
41 myelitis 30.6 TNF IL6 IL10 CXCL8
42 urinary tract infection 30.6 TNF TLR2 IL6 IL1B IL10 CXCL8
43 syphilis 30.6 TNF TLR2 CRP
44 q fever 30.6 TNF TLR2 IL6 IL1B IL10 IFNG
45 chickenpox 30.6 TNF IL6 IL1B IL10 IFNG CRP
46 necrotizing fasciitis 30.6 TNF IL6 IL1B CXCL8 CRP
47 mycobacterium marinum 30.6 TLR2 CXCL8
48 aortic aneurysm 30.6 TNF IL6 IL1B IL10 CXCL8 CRP
49 invasive aspergillosis 30.6 TNF TLR2 IL6 IL10 CRP
50 acquired immunodeficiency syndrome 30.5 TNF IL6 IL1B IL10 IFNG CRP

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


bone pain; pain in limb

GenomeRNAi Phenotypes related to Osteomyelitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.14 ACP5 BMP2 CASP1 CRP CTSK CXCL8
2 no effect GR00402-S-2 10.14 ACP5 CASP1 CRP IFNG IFNGR1 IL10
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.73 CXCL8 IL10 IL1A IL1B NLRP3 TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.73 CASP1 CXCL8 IL10 IL1B NLRP3 TNF

MGI Mouse Phenotypes related to Osteomyelitis:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.44 BMP2 CASP1 CRP CTSK IFNG IFNGR1
2 growth/size/body region MP:0005378 10.37 BMP2 CASP1 CTSK FBLIM1 IFNG IL10
3 nervous system MP:0003631 10.36 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
4 immune system MP:0005387 10.35 ACP5 BMP2 CASP1 CRP CTSK FBLIM1
5 neoplasm MP:0002006 10.26 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
6 cardiovascular system MP:0005385 10.22 BMP2 CASP1 CRP IFNG IFNGR1 IL10
7 cellular MP:0005384 10.21 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
8 endocrine/exocrine gland MP:0005379 10.18 CASP1 CTSK FBLIM1 IFNG IFNGR1 IL10
9 digestive/alimentary MP:0005381 10.16 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
10 liver/biliary system MP:0005370 10.14 IFNG IFNGR1 IL10 IL6 LPIN2 NLRP3
11 limbs/digits/tail MP:0005371 10.13 ACP5 BMP2 CTSK FBLIM1 IL10 NLRP3
12 hematopoietic system MP:0005397 10.11 ACP5 BMP2 CASP1 CTSK FBLIM1 IFNG
13 reproductive system MP:0005389 10.1 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
14 skeleton MP:0005390 10.1 ACP5 BMP2 CTSK FBLIM1 IFNG IFNGR1
15 mortality/aging MP:0010768 9.8 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
16 integument MP:0010771 9.4 CASP1 IFNG IFNGR1 IL10 IL1A IL1B

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-91-8, 4205-90-7 2803 20179
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530
3
Cefazolin Approved Phase 4 25953-19-9 33255
4
Dalbavancin Approved, Investigational Phase 4 171500-79-1 16134627
5
Nafcillin Approved, Investigational Phase 4 985-16-0, 147-52-4 8982
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
7
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
8
Dicloxacillin Approved, Investigational, Vet_approved Phase 4 3116-76-5 18381
9
Flucloxacillin Approved, Investigational Phase 4 5250-39-5, 34214-51-2 21319
10
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
11
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294
12
Oritavancin Approved, Investigational Phase 4 171099-57-3 16136912
13
Vancomycin Approved Phase 4 1404-90-6 14969
14
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
15
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
17
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
18 Adrenergic alpha-Agonists Phase 4
19 Adrenergic Agonists Phase 4
20 Antihypertensive Agents Phase 4
21 Sympatholytics Phase 4
22 Folate Phase 4
23 Vitamin B9 Phase 4
24 beta-Lactamase Inhibitors Phase 4
25 Vitamin B Complex Phase 4
26 Coagulase Phase 4
27 Dermatologic Agents Phase 4
28 Antitubercular Agents Phase 4
29 Amoxicillin-Potassium Clavulanate Combination Phase 4
30 Vitamins Phase 4
31 Trace Elements Phase 4
32 Photosensitizing Agents Phase 4
33
Vitamin B2 Phase 4
34 Micronutrients Phase 4
35 Gentamicins Phase 4
36 Analgesics, Opioid Phase 4
37
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
38
Tannic acid Approved Phase 3 1401-55-4 16129878 16129778
39
Ertapenem Approved, Investigational Phase 3 153832-46-3 150610
40
Tigecycline Approved Phase 3 220620-09-7 5282044
41
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1, 93107-08-5 2764
42
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
43
Sulfamethoxazole Approved Phase 3 723-46-6 5329
44
Clindamycin Approved, Vet_approved Phase 3 18323-44-9, 24729-96-2 29029
45
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
46
Cefotaxime Approved Phase 3 63527-52-6 5742673 456256
47
Fusidic acid Approved, Investigational Phase 3 6990-06-3 3000226
48
Ofloxacin Approved Phase 3 82419-36-1 4583
49
Rifampicin Approved Phase 3 13292-46-1 135512673 5381226 135900090
50
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study Completed NCT02123628 Phase 4 duration of the antibiotic therapy
3 Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
4 Clonidine for Tourniquet-related Pain in Children: A Pilot Study Recruiting NCT04564430 Phase 4 Catapresan
5 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
6 CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
7 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
8 Oral-only Antibiotics for Bone and Joint Infections in Children - A Nationwide Randomized Controlled Trial Recruiting NCT04563325 Phase 4 Oral co-amoxiclav or oral dicloxacillin only;IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
9 BonE and Joint Infections - Simplifying Treatment in Children Trial Recruiting NCT04538053 Phase 4 Oral cefalexin only;IV cefazolin or IV flucloxacillin followed by oral cefalexin
10 Anchoring Intermittent Long Acting Antimicrobials to Medication for Opioid Use Disorder Treatment to Facilitate Structured Transitions of Care for People Who Use Drugs Admitted to the Hospital With Invasive Infections Not yet recruiting NCT05521880 Phase 4 Oritavancin
11 Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial Not yet recruiting NCT05421741 Phase 4 Antibiotic coated intramedullary Nail
12 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
13 Comparison of Medical and Medical-surgical Management of Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
14 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
15 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
16 A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline Versus Ertapenem for the Treatment of Foot Infections in Subjects With Diabetes Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
17 Three Weeks Versus Six Weeks Antibiotic Therapy for Nonsurgically Treated Diabetic Foot Osteomyelitis : a Multicenter, Randomized, Open-label and Controlled Study Not yet recruiting NCT05074147 Phase 3 Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks
18 A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to Gram-Positive Organisms Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
19 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
20 Phase 1/2 Trial of Ceftaroline for the Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Completed NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
21 A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthetic Hip or Knee Joint Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
22 A Phase 2, Single-center, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-Positive Organisms Completed NCT02685033 Phase 2 Dalbavancin;Comparator
23 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
24 A Phase IIa Randomized, Parallel Group, Double-blind, Repeat Dose, Investigating the Safety, Tolerability, and Efficacy of Phage Treatment and Standard of Care Antimicrobials for Patients With Diabetic Foot Osteomyelitis Recruiting NCT05177107 Phase 2
25 A Multi-center, Randomized, Controlled Feasibility Trial of Stimulan-VG and Debridement With an Abbreviated Course of Systemic Antibiotics to Debridement and a Full Course of Systemic Antibiotics for the Treatment of Diabetic Foot Osteomyelitis of the Forefoot Not yet recruiting NCT05539963 Phase 2 Stimulan-VG;Systemic Antibiotics
26 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) Terminated NCT02168816 Phase 2 Intravenous Antibacterial Agent;Oral Antibacterial Agent
27 A Phase 2, Multicenter, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-positive Organisms Terminated NCT03091439 Phase 2 Dalbavancin;Standard of Care
28 Exploration of the Use of [124I]FIAU Positron Emission Tomography-Computed Tomography Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection. Terminated NCT01764919 Phase 2
29 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Completed NCT03802552 Phase 1 Cefadroxil;Cephalexin
30 Plasma-Based Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections Unknown status NCT03846804
31 Prospective Randomized Clinical Trial Comparing Efficacy Surgical Versus Medical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903 Ciprofloxacin;Amoxicillin-Potassium Clavulanate Combination;Sulfamethoxazole trimethoprim
32 Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis: a Randomized Multicentre Trial Unknown status NCT04436328
33 A Prospective, Randomized Trial Comparing Vancomycin With Trimethoprim/Sulfamethoxazole for the Treatment of MRSA Osteomyelitis Unknown status NCT00324922 trimethoprim-sulfamethoxazole;vancomycin
34 The Effect of Fungal Infection on the Outcome Among Diabetic Patients With Foot Osteomyelitis Unknown status NCT04041739
35 Assessment of White Blood Cell SPECT/CT in Monitoring Antibiotic Treatment in Patients With Diabetic Foot Osteomyelitis Unknown status NCT02927678
36 Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis Unknown status NCT01473979
37 Sensitivity, Specificity and Predictive Value of High Resolution (B-Mode) Ultrasonography (HRUS) for the Detection of Osteomyelitis in Chronic Wound Patients Unknown status NCT02198755
38 Development of Risk Score Model and Decision Tree Algorithm for Predicting Bloodstream Infections (BSIs) or Other Invasive Infections With Carbapenem Resistant Klebisella Penumoniae (CRKp) in CRKp Colonized Patients (DETERMINE) Unknown status NCT04229511
39 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
40 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Completed NCT02308774
41 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Completed NCT02165579
42 Hematogenous Osteomyelitis in Childhood Can Relapse Dozens of Years in Adulthood Completed NCT03898219
43 Pressure Ulcer-associated Osteomyelitis: Retrospective Evaluation of a Two-stage Surgical Strategy (Debridement With Vacuum-assisted Closure Therapy and Reconstruction) With Prolonged Antimicrobial Therapy Completed NCT03010293
44 Biofilm Formation Increases Treatment Failure in Staphylococcus Epidermidis Device-related Osteomyelitis in Human Patients Completed NCT02640937
45 Studying on the Difference Between Foot Osteomyelitis Patients With or Without Diabetes Completed NCT04240964
46 Determining of Independent Risk Factors for Three Critical Stages of the Diabetic Foot Infections Without Using the Well-known Classification Systems: Osteomyelitis, Amputation and Major Amputation Completed NCT02736253
47 SPONDIMMO : Multicentered Descriptive Prospective Study of Immobilization and Neurological Complication in Patients With Vertebral Osteomyelitis. Completed NCT04655950
48 Drug Delivery Devices for Osteomyelitis Completed NCT02968693 Vancomycin
49 Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis Completed NCT01125839
50 Inflammatory Biomarkers to Diagnose and Monitor Diabetic Foot Osteomyelitis Completed NCT04025853

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ciprofloxacin

Cochrane evidence based reviews: osteomyelitis

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 28

Anatomical Context for Osteomyelitis

Organs/tissues related to Osteomyelitis:

FMA: Bone, Bone Marrow
MalaCards : Bone, Bone Marrow, Spinal Cord, Skin, Prostate, Neutrophil, Heart

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 24824)
# Title Authors PMID Year
1
Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency. 53 62
19880337 2010
2
Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein-2 for vertebral osteomyelitis. 53 62
17233287 2007
3
RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. 53 62
17032395 2006
4
Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. 53 62
15872059 2005
5
[The study of the antioxidant enzymes in erythrocytes in lung diseases]. 53 62
12838770 2003
6
Genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. 53 62
11865431 2002
7
Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. 53 62
11792597 2002
8
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. 53 62
11139207 2001
9
Antimicrobial treatment of chronic osteomyelitis. 53 62
10101310 1999
10
Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. 53 62
9581562 1997
11
The effect of growth temperature on Staphylococcus aureus binding to type I collagen. 53 62
7715422 1994
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 53 62
8382334 1993
13
Radiologic finding of intraosseous gas: A rare case of emphysematous osteomyelitis of the foot. 62
36471739 2023
14
Image-guided percutaneous bone biopsy for pediatric osteomyelitis: correlating MRI findings, tissue pathology and culture, and effect on clinical management. 62
35882659 2023
15
Management of bone diseases: looking at scaffold-based strategies for drug delivery. 62
35816230 2023
16
Hybrid imaging of Diabetic Foot Infections. 62
36089528 2023
17
PET-Computed Tomography in Bone and Joint Infections. 62
36442966 2023
18
D-dimer may aid in the diagnosis of pediatric musculoskeletal infections: a prospective study. 62
35703242 2023
19
First recorded outbreak of Veronaea botryosa in North American amphibians: Clinicopathologic features of a rare cause of phaeohyphomycosis in captive White's tree frogs (Litoria caerulea). 62
36193194 2022
20
Synergistic Antibacterial Effect and Mechanism of Allicin and an Enterobacter cloacae Bacteriophage. 62
36472428 2022
21
Unstable Ankle Fractures in Neuropathic Diabetics. 62
36107123 2022
22
A European survey on post-mortem inspection of finishing pigs: Total condemnation criteria to declare meat unfit for human consumption. 62
35932591 2022
23
A Novel Technique of Robotic-Assisted Simple Cystectomy During Urinary Diversion for Benign Indications. 62
36462582 2022
24
Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions. 62
36453574 2022
25
Comparison of the clinical outcomes between vascularized bone graft and the Masquelet technique for the reconstruction of Gustilo type III open tibial fractures. 62
36451238 2022
26
Isolation of Lactococcus garvieae NEP21 from raw cow (Bos indicus) milk in Nepal. 62
36470377 2022
27
Management patterns and outcomes of patients hospitalized with diabetic foot ulcers at one tertiary care hospital. 62
36474123 2022
28
A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection. 62
36382133 2022
29
Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients. 62
36031963 2022
30
Plantar Skin Defect Reconstruction: A Large Series With a 15-Year Follow-up. 62
33393408 2022
31
Management of Seymour Fractures in Children and Adolescents: A Systematic Review and Meta-Analysis. 62
34810026 2022
32
Intensive Glycemic Control for Diabetic Foot Ulcer Healing: A Multicentric, Randomized, Parallel Arm, Single-Blind, Controlled Study Protocol (INGLOBE Study). 62
32907433 2022
33
Preventing osteolytic lesions and osteomyelitis in multiple myeloma. 62
36388641 2022
34
The dark satanic mills: Evaluating patterns of health in England during the industrial revolution. 62
36335796 2022
35
Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component. 62
35802244 2022
36
Two phenotypes of chronic recurrent multifocal osteomyelitis with different patterns of bone involvement. 62
36456962 2022
37
Review on skeletal disorders caused by Staphylococcus spp. in poultry. 62
35076352 2022
38
Distally Based Peroneal Artery Perforator-Plus Fasciocutaneous Flap to Reconstruct Soft Tissue Defect Combined With Chronic Osteomyelitis in the Lateral Malleolus. 62
32912022 2022
39
Squamous cell carcinoma complicating chronic osteomyelitis: A systematic review and case series. 62
34969605 2022
40
Four cases of abdominal expander implantation in adult chronic osteomyelitis of lower extremity with soft tissue defect and literature review. 62
35302286 2022
41
Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw. 62
36345763 2022
42
Local Antibiotic Delivery Systems in the Surgical Treatment of Diabetic Foot Osteomyelitis: Again, No Benefit? 62
33295248 2022
43
Escalation of antimicrobial resistance among MRSA part 2: focus on infections and treatment. 62
36469648 2022
44
[Clinical characteristics of 18 children with chronic nonbacterial osteomyelitis]. 62
36444429 2022
45
Kingella kingae Osteomyelitis Should be Ruled out in Pediatric Langerhans Cell Histiocytosis. 62
36102720 2022
46
Emphysematous osteomyelitis of the spine mimicking esophageal rupture. 62
35905773 2022
47
Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review. 62
36351221 2022
48
Sacral Insufficiency Fractures After Total Pubectomy for Osteomyelitis: A Case Series. 62
36115424 2022
49
Prospective Validation of the Value of Adding Osteomyelitis to Moderate and Severe Categories of Diabetic Foot Infections. 62
35924359 2022
50
Diagnostic performance of quantitative Ga-SPECT/CT for patients with lower-limb osteomyelitis. 62
36450868 2022

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CASP1 CRP CTSK CXCL8 IFNG IFNGR1
2
Show member pathways
13.88 BMP2 CXCL8 FBLIM1 IL10 IL1A IL1B
3
Show member pathways
13.72 BMP2 CASP1 CXCL8 IFNG IL10 IL1A
4
Show member pathways
13.61 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
5
Show member pathways
13.54 TNF TLR2 PPP3CA IL6 IL1B IL1A
6
Show member pathways
13.5 BMP2 CXCL8 IL10 IL1A IL1B IL6
7
Show member pathways
13.41 TNFSF11 TNF IL6 IL1B IL1A IL10
8
Show member pathways
13.4 TNFSF11 TNF IL6 IL1RN IL1B IL1A
9
Show member pathways
13.35 PPP3CA NLRP3 IL6 IL1B IL1A IL10
10
Show member pathways
12.93 TNF TLR2 IL6 IL1B IL1A CXCL8
11
Show member pathways
12.88 TNF PPP3CA IL6 IL1B IL1A
12
Show member pathways
12.81 TNF TLR2 IL6 IL1B IL1A BMP2
13
Show member pathways
12.77 TNFSF11 TNF TLR2 PPP3CA IL1B IL1A
14 12.76 NLRP3 IL6 IL1B IL10 CASP1
15
Show member pathways
12.75 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
16
Show member pathways
12.74 TNF IL1B IL1A IFNGR1 IFNG
17
Show member pathways
12.73 TNF TLR2 PPP3CA IL6 IL1RN IL1B
18
Show member pathways
12.66 IFNG IL10 IL1B IL6 TNF
19 12.66 TNFSF11 TNF TLR2 PPP3CA IL1RN IL1B
20
Show member pathways
12.65 TNF TLR2 NLRP3 IL6 IL1B CXCL8
21
Show member pathways
12.46 TNF IL6 IL1B IL1A IFNGR1 IFNG
22 12.45 TNF PPP3CA IL1B IL1A
23
Show member pathways
12.34 TNF TLR2 IL6 CXCL8
24 12.31 TNF TLR2 IL6 IFNGR1 IFNG
25 12.27 TNF IL6 IL1RN IL1B IL1A IL10
26 12.18 TNF IL6 IL1B IL1A IL10 IFNGR1
27 12.15 TNF LPIN2 IL6 BMP2
28 12.12 TNF IL6 IL1B IL1A IL10 CXCL8
29 12.1 IL6 IL1B IL1A IFNG CXCL8 BMP2
30 12.09 TNF IL6 IL10 IFNG
31
Show member pathways
12.05 TNF TLR2 IL6 IL1RN IL1B IL1A
32
Show member pathways
12.04 NLRP3 IL1B IL1A CASP1
33 12.04 TNF PPP3CA IL6 IL1B IL1A IFNG
34 12.01 TNF IL1B IL1A IL10 IFNG CXCL8
35
Show member pathways
11.98 TLR2 IL6 IL1B IFNG
36
Show member pathways
11.96 IFNG IFNGR1 IL1B NLRP3 TNF
37 11.92 TNF IL6 IL1B IL10 IFNG
38 11.91 TNF IL1B IL10 IFNG
39 11.91 TNFSF11 IL6 CTSK BMP2
40
Show member pathways
11.91 TNF TLR2 IL6 IL1B IL10 IFNGR1
41 11.9 IL6 IFNGR1 IFNG
42 11.9 TNF IL6 IL10 IFNG CRP
43 11.88 TNF IL6 IL1B CXCL8
44 11.88 PPP3CA IL6 IL1B IFNGR1 IFNG
45 11.84 IL6 IL10 IFNG CXCL8
46
Show member pathways
11.82 IL6 CXCL8 CRP
47 11.82 IL6 IFNG CXCL8
48 11.82 TNF IL6 IL1A IL10 CXCL8
49 11.81 IL6 IL10 IFNG
50 11.8 TNF IL6 IL1B CXCL8

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 TNFSF11 TNF NLRP3 IL6 IL1RN IL1B
2 extracellular space GO:0005615 9.7 BMP2 CRP CTSK CXCL8 IFNG IL10

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.63 BMP2 IL10 IL1A IL1B IL6 LPIN2
2 signal transduction GO:0007165 10.61 CASP1 CXCL8 IFNG IFNGR1 IL10 IL1B
3 apoptotic process GO:0006915 10.49 TNF TLR2 NLRP3 IL1B IL1A IFNG
4 negative regulation of cell population proliferation GO:0008285 10.43 BMP2 CXCL8 IL10 IL1A IL1B IL6
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.38 CASP1 IL1A IL1B TNF TNFSF11
6 defense response to virus GO:0051607 10.36 CASP1 IFNG IL6 NLRP3 TLR2
7 cytokine-mediated signaling pathway GO:0019221 10.35 TNFSF11 IL6 IL1B IL1A IFNGR1
8 positive regulation of JNK cascade GO:0046330 10.3 TNFSF11 TNF IL1B IL1A
9 positive regulation of tumor necrosis factor production GO:0032760 10.3 IFNG IFNGR1 IL1A IL6 TLR2
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.27 TNFSF11 TNF TLR2 NLRP3 IL6 IL1B
11 positive regulation of interleukin-8 production GO:0032757 10.25 IL1B IL6 TLR2 TNF
12 response to glucocorticoid GO:0051384 10.24 TNF IL6 IL1RN IL10
13 calcium-mediated signaling GO:0019722 10.23 TNFSF11 TNF PPP3CA CXCL8
14 regulation of insulin secretion GO:0050796 10.23 IFNG IL1B IL6 TNF
15 cellular response to virus GO:0098586 10.22 NLRP3 IL6 IFNGR1 IFNG
16 positive regulation of inflammatory response GO:0050729 10.22 TNF TLR2 NLRP3 IL1B IFNG CASP1
17 positive regulation of interleukin-1 beta production GO:0032731 10.21 TNF NLRP3 IL6 IFNG CASP1
18 positive regulation of nitric oxide biosynthetic process GO:0045429 10.2 TNF IL1B IFNG
19 osteoclast differentiation GO:0030316 10.2 TNFSF11 TNF BMP2
20 positive regulation of cytokine production GO:0001819 10.2 TNF IL1B IL1A IL10 IFNG
21 lipopolysaccharide-mediated signaling pathway GO:0031663 10.19 IL1B TLR2 TNF
22 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.19 TNF IL1B IL1A
23 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.19 TNF IL6 IL10
24 positive regulation of mitotic nuclear division GO:0045840 10.18 TNF IL1B IL1A
25 liver regeneration GO:0097421 10.18 TNF IL6 IL10
26 microglial cell activation GO:0001774 10.18 TNF TLR2 IFNGR1 IFNG
27 positive regulation of interleukin-6 production GO:0032755 10.18 TNF TLR2 IL6 IL1B IL1A IFNG
28 defense response to Gram-positive bacterium GO:0050830 10.18 ACP5 CRP IL1B IL6 NLRP3 TLR2
29 positive regulation of vascular endothelial growth factor production GO:0010575 10.17 IL6 IL1B IL1A
30 positive regulation of DNA-binding transcription factor activity GO:0051091 10.17 TNFSF11 TNF PPP3CA IL6 IL1B IL10
31 negative regulation of neurogenesis GO:0050768 10.16 TNF IL6 IL1B
32 bone resorption GO:0045453 10.16 TNFSF11 CTSK ACP5
33 inflammatory response GO:0006954 10.16 TNF TLR2 NLRP3 IL6 IL1RN IL1B
34 positive regulation of amyloid-beta formation GO:1902004 10.14 TNF IFNGR1 IFNG
35 response to lipopolysaccharide GO:0032496 10.14 TNF TLR2 IL1B IL1A IL10 ACP5
36 positive regulation of glial cell proliferation GO:0060252 10.13 TNF IL6 IL1B
37 positive regulation of osteoclast differentiation GO:0045672 10.13 IFNG PPP3CA TNF TNFSF11
38 cellular response to lipopolysaccharide GO:0071222 10.13 CASP1 CXCL8 IL10 IL1A IL1B IL6
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.12 TNF IL1B IFNG
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.11 TNF IL1B IL10
41 negative regulation of amyloid-beta clearance GO:1900222 10.09 TNF IFNGR1 IFNG
42 positive regulation of neuroinflammatory response GO:0150078 10.09 TNF IL6 IL1B
43 positive regulation of chemokine production GO:0032722 10.09 TNF TLR2 IL6 IL1B IFNG
44 negative regulation of lipid storage GO:0010888 10.08 TNF IL6 CRP
45 vascular endothelial growth factor production GO:0010573 10.07 TNF IL6 IL1B
46 astrocyte activation GO:0048143 10.06 IFNG IFNGR1 IL1B TNF
47 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 10.03 IL6 IL1RN
48 positive regulation of immature T cell proliferation in thymus GO:0033092 10.03 IL1B IL1A
49 negative regulation of cytokine production involved in immune response GO:0002719 10.02 TNF IL10
50 positive regulation of fever generation GO:0031622 10.02 TNF IL1B

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.6 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 9.35 IL1RN IL1B IL1A

Sources for Osteomyelitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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