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MCID: OST017
MIFTS: 63

Osteomyelitis

Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Osteomyelitis

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MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 74 20 29 54 15 17 71 32

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1019
ICD9CM 34 730.1
SNOMED-CT 67 203181001
ICD10 32 M86 M86.9
UMLS 71 C0008707 C0029443
Sources

Summaries for Osteomyelitis

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GARD : 20 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to sapho syndrome and chronic recurrent multifocal osteomyelitis, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fusidic Acid and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 74 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Sources

Related Diseases for Osteomyelitis

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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1371)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 32.4 LPIN2 FBLIM1 CXCL8
2 chronic recurrent multifocal osteomyelitis 32.2 TNFSF11 TNF NLRP3 LPIN2 IL6 IL1RN
3 mycobacterium fortuitum 32.0 IFNGR1 CXCL8
4 petrositis 31.9 IFNG CRP
5 osteopetrosis 31.7 TNFSF11 TNF IFNG CTSK ACP5
6 chronic granulomatous disease 31.7 TNF IL1B IFNG CXCL8 CASP1
7 septic arthritis 31.6 TLR2 IFNG CXCL8 CRP
8 back pain 31.4 IL6 IL1RN IL1B IL1A
9 periostitis 31.3 LPIN2 IL1RN CRP
10 cellulitis 31.2 TNFSF11 TNF IL6 CRP
11 toxic shock syndrome 31.1 TNF TLR2 IL6 IL1RN IL1B IL10
12 osteonecrosis 31.0 TNFSF11 TNF IL1B BMP2 ACP5
13 haemophilus influenzae 31.0 TNF TLR2 CXCL8
14 cryptococcosis 30.9 TNF IL10 IFNG
15 actinomycosis 30.9 TNF IL6 IL1B IL10 CRP
16 sickle cell anemia 30.9 TNF IL6 IL1B IL10 CXCL8 CRP
17 fasciitis 30.8 TNF IL6 IL1RN IFNG CXCL8
18 skeletal tuberculosis 30.8 TNF IFNG CRP
19 infective endocarditis 30.8 TNF TLR2 IL6 CRP
20 tenosynovitis 30.8 TNF IL6 IL1B CRP
21 spinal cord injury 30.8 TNF IL6 CXCL8
22 pyoderma gangrenosum 30.8 TNF NLRP3 CXCL8
23 myositis 30.8 TNF IL6 IL1B IL1A IFNG CXCL8
24 vascular disease 30.7 TNF IL6 IL1A IL10 IFNG CRP
25 acne 30.7 TNF TLR2 IL6 IL1RN IL1B IL1A
26 pyoderma 30.7 TNF NLRP3 IL1B CXCL8
27 mycobacterium chelonae 30.7 TLR2 CXCL8
28 bursitis 30.7 TNF IL6 IL1B CRP
29 endocarditis 30.7 TNF TLR2 IL6 IL1A IL10 IFNG
30 chickenpox 30.7 TNF IL6 IL10 IFNG CRP
31 invasive aspergillosis 30.7 TLR2 IL10 IFNG CXCL8
32 melioidosis 30.7 TNF TLR2 IL6 IL10 IFNG
33 spondylitis 30.7 TNFSF11 TNF IL6 IL1B IL10 IFNG
34 smallpox 30.7 TNF IL1RN IL1B IFNG
35 decubitus ulcer 30.7 TNF IL6 IL1B IL1A CRP
36 ankylosis 30.6 TNFSF11 TNF BMP2
37 necrotizing fasciitis 30.6 IL6 IL1RN IL1B CXCL8 CRP
38 nocardiosis 30.6 TNF IFNG CRP
39 compartment syndrome 30.6 TNF IL6 CRP
40 chronic ulcer of skin 30.6 TNF IL6 IL1B CRP
41 mycobacterium tuberculosis 1 30.6 TNF TLR2 IL10 IFNGR1 IFNG
42 pycnodysostosis 30.6 TNFSF11 CTSK ACP5
43 myelitis 30.6 TNF IL6 IL10 CXCL8
44 mycobacterium marinum 30.6 TLR2 CXCL8
45 prosthetic joint infection 30.5 TLR2 IL6 IL1B CRP
46 sarcoidosis 1 30.5 TNF IL1RN IL1B IL1A IFNG CRP
47 brucellosis 30.5 TNF IL6 IL1RN IL10 IFNG CXCL8
48 mycobacterium kansasii 30.5 TLR2 NLRP3 CXCL8
49 pericarditis 30.5 TNF IL6 IL1B IFNG CXCL8 CRP
50 disease by infectious agent 30.5 TNF TLR2 IL6 IL1RN IL1B IL10

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis
Sources

Symptoms & Phenotypes for Osteomyelitis

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UMLS symptoms related to Osteomyelitis:


bone pain, pain in limb

GenomeRNAi Phenotypes related to Osteomyelitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CXCL8 IL10 IL1A IL1B NLRP3 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 CXCL8 IL10 IL1B NLRP3 TNF

MGI Mouse Phenotypes related to Osteomyelitis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.42 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
2 homeostasis/metabolism MP:0005376 10.41 BMP2 CASP1 CRP CTSK IFNG IFNGR1
3 immune system MP:0005387 10.41 BMP2 CASP1 CRP CTSK FBLIM1 IFNG
4 growth/size/body region MP:0005378 10.39 BMP2 CASP1 CTSK FBLIM1 IFNG IL10
5 cardiovascular system MP:0005385 10.37 BMP2 CASP1 CRP IFNG IFNGR1 IL10
6 cellular MP:0005384 10.33 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
7 digestive/alimentary MP:0005381 10.24 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
8 endocrine/exocrine gland MP:0005379 10.22 CASP1 CTSK FBLIM1 IFNG IFNGR1 IL10
9 integument MP:0010771 10.21 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
10 mortality/aging MP:0010768 10.17 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
11 liver/biliary system MP:0005370 9.97 IFNG IFNGR1 IL10 IL6 LPIN2 NLRP3
12 nervous system MP:0003631 9.97 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
13 neoplasm MP:0002006 9.96 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
14 limbs/digits/tail MP:0005371 9.95 BMP2 CTSK FBLIM1 IL10 NLRP3 TNF
15 reproductive system MP:0005389 9.73 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
16 skeleton MP:0005390 9.44 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10
Sources

Drugs & Therapeutics for Osteomyelitis

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Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fusidic Acid Approved, Investigational Phase 4 6990-06-3 3000226
2
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
7
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
8
Ofloxacin Approved Phase 4 82419-36-1 4583
9
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
10
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
11
Vancomycin Approved Phase 4 1404-90-6 441141 14969
12
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
13
Nafcillin Approved, Investigational Phase 4 147-52-4, 985-16-0 8982
14
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
15
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
16
Dicloxacillin Approved, Investigational, Vet_approved Phase 4 3116-76-5 18381
17
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
18
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
19
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
20
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
21
Cefazolin Approved Phase 4 25953-19-9 656510 33255
22
Clonidine Approved Phase 4 4205-90-7 2803
23
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
24
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
25
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
26
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
27 Cytochrome P-450 Enzyme Inhibitors Phase 4
28 Folic Acid Antagonists Phase 4
29 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
30 Antiparasitic Agents Phase 4
31 Antiprotozoal Agents Phase 4
32 Antimalarials Phase 4
33 Vitamin B Complex Phase 4
34 Vitamin B9 Phase 4
35 beta-Lactamase Inhibitors Phase 4
36 Folate Phase 4
37 Coagulase Phase 4
38 Amoxicillin-Potassium Clavulanate Combination Phase 4
39 Antitubercular Agents Phase 4
40 Dermatologic Agents Phase 4
41 Nutrients Phase 4
42 Micronutrients Phase 4
43 Trace Elements Phase 4
44 Vitamin B2 Phase 4
45 Vitamins Phase 4
46 Photosensitizing Agents Phase 4
47 Pharmaceutical Solutions Phase 4
48 Analgesics Phase 4
49 Adrenergic alpha-Agonists Phase 4
50 Sympatholytics Phase 4

Interventional clinical trials:

(show top 50) (show all 80)
# Name Status NCT ID Phase Drugs
1 CERAMENTâ„¢|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
3 Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study Completed NCT02123628 Phase 4 duration of the antibiotic therapy
4 Oral-only Antibiotics for Bone and Joint Infections in Children - A Nationwide Randomized Controlled Trial Recruiting NCT04563325 Phase 4 Oral co-amoxiclav or oral dicloxacillin only;IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
5 CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
6 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
7 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
8 Clonidine for Tourniquet-related Pain in Children: A Pilot Study Not yet recruiting NCT04564430 Phase 4 Catapresan
9 BonE and Joint Infections - Simplifying Treatment in Children Trial Not yet recruiting NCT04538053 Phase 4 Oral cefalexin only;IV cefazolin followed by oral cefalexin
10 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
11 Comparison of Medical and Medical-surgical Management of Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
12 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
13 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
14 A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline Versus Ertapenem for the Treatment of Foot Infections in Subjects With Diabetes Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
15 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
16 A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to Gram-Positive Organisms Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
17 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
18 A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthetic Hip or Knee Joint Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
19 A Phase 2, Single-center, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-Positive Organisms Completed NCT02685033 Phase 2 Dalbavancin;Comparator
20 Phase 1/2 Trial of Ceftaroline for the Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Completed NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
21 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
22 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
23 The Use of Antimicrobial Synthetic Bone Grafts in the Treatment of Bone Infection Active, not recruiting NCT03945864 Phase 1, Phase 2
24 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) Terminated NCT02168816 Phase 2 Intravenous Antibacterial Agent;Oral Antibacterial Agent
25 A Phase 2, Multicenter, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-positive Organisms Terminated NCT03091439 Phase 2 Dalbavancin;Standard of Care
26 Exploration of the Use of [124I]FIAU Positron Emission Tomography-Computed Tomography Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection. Terminated NCT01764919 Phase 2
27 A Prospective, Non-Randomized, Open-Label Study on the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
28 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
29 Sensitivity, Specificity and Predictive Value of High Resolution (B-Mode) Ultrasonography (HRUS) for the Detection of Osteomyelitis in Chronic Wound Patients Unknown status NCT02198755
30 Correlation Between Middle Turbinate Histopathology and Computed Tomography Staging in Chronic Rhinosinusitis Unknown status NCT00899561
31 Prospective Randomized Clinical Trial Comparing Efficacy Surgical Versus Medical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903 Ciprofloxacin;Amoxicillin-Potassium Clavulanate Combination;Sulfamethoxazole trimethoprim
32 A Prospective, Randomized Trial Comparing Vancomycin With Trimethoprim/Sulfamethoxazole for the Treatment of MRSA Osteomyelitis Unknown status NCT00324922 trimethoprim-sulfamethoxazole;vancomycin
33 Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics Unknown status NCT02099240 Early Phase 1 oral antibiotics
34 Assessment of White Blood Cell SPECT/CT in Monitoring Antibiotic Treatment in Patients With Diabetic Foot Osteomyelitis Unknown status NCT02927678
35 Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis Unknown status NCT01473979
36 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
37 Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection Completed NCT03808285
38 Can we Improve the Treatment of Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures by Using Perioperative Immunoinflammatory Markers? Completed NCT03459261
39 Acinetobacter Baumannii-related Osteomyelitis: Clinical and Epidemiological Characterization Completed NCT03559530 Antimicrobial
40 Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis Completed NCT01125839
41 Randomized Study Comparing Different Durations of Antibiotic Treatment for Diabetic Foot Infections Completed NCT03615807 Antibiotic duration
42 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Completed NCT02165579
43 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Completed NCT02308774
44 Pilot Evaluation of PCR Multiplex Tests for a Rapid Diagnosis of Bone Infections in Diabetic Foot Completed NCT03434288
45 Studying on the Difference Between Foot Osteomyelitis Patients With or Without Diabetes Completed NCT04240964
46 SPONDIMMO : Multicentered Descriptive Prospective Study of Immobilization and Neurological Complication in Patients With Vertebral Osteomyelitis. Completed NCT04655950
47 LOOP- Long- and Midterm Outcomes of Osteoarticular Infections in Paediatric Patients. Completed NCT03827980
48 Hematogenous Osteomyelitis in Childhood Can Relapse Dozens of Years in Adulthood Completed NCT03898219
49 Drug Delivery Devices for Osteomyelitis Completed NCT02968693 Vancomycin
50 Risk Factors Associated With Recurrence and Life-threatening Complications for Patients Hospitalized With Chronic Suppurative Osteomyelitis of the Jaw Completed NCT01670422

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Ciprofloxacin
Sources

Genetic Tests for Osteomyelitis

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Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis (disease) 29
Sources

Anatomical Context for Osteomyelitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

19
Bone, Bone Marrow

MalaCards organs/tissues related to Osteomyelitis:

40
Bone, Skin, Bone Marrow, Spinal Cord, Brain, Prostate, Kidney
Sources

Publications for Osteomyelitis

About this section

Articles related to Osteomyelitis:

(show top 50) (show all 22824)
# Title Authors PMID Year
1
Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency. 54 61
19880337 2010
2
Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein-2 for vertebral osteomyelitis. 61 54
17233287 2007
3
RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. 61 54
17032395 2006
4
Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. 54 61
15872059 2005
5
[The study of the antioxidant enzymes in erythrocytes in lung diseases]. 54 61
12838770 2003
6
Genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. 54 61
11865431 2002
7
Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. 54 61
11792597 2002
8
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. 54 61
11139207 2001
9
Antimicrobial treatment of chronic osteomyelitis. 54 61
10101310 1999
10
Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. 61 54
9581562 1997
11
The effect of growth temperature on Staphylococcus aureus binding to type I collagen. 61 54
7715422 1994
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 61 54
8382334 1993
13
Functional Limb Restoration Through Amputation: Minimizing Pain and Optimizing Function With the Use of Advanced Amputation Techniques. 61
33378296 2021
14
Osteomyelitis Caused by Hypervirulent Klebsiella pneumoniae: The First Korean Case With Family Spread. 61
33063690 2021
15
Current Concepts in Pediatric Septic Arthritis. 61
33273402 2021
16
Osteomyelitis, osteoradionecrosis, or medication-related osteonecrosis of the jaws? Can CBCT enhance radiographic diagnosis? 61
32623770 2021
17
Long-Term Outcomes of Cochlear Implantation in Irradiated Ears of Nasopharyngeal Carcinoma Patients. 61
32815553 2021
18
Whole-body magnetic resonance imaging in inflammatory diseases: Where are we now? Results of an International Survey by the European Society of Musculoskeletal Radiology. 61
33454461 2021
19
Development of osteomyelitis following dental abscesses-influence of therapy and comorbidities. 61
32638128 2021
20
Role of ultrasound and CT in the early diagnosis and surgical treatment of primary sternal osteomyelitis caused by Salmonella: Case reports. 61
33488798 2021
21
Management of Gustilo type IIIB open tibial shaft fractures with limited resources: experience from an African trauma center. 61
31482301 2021
22
Outcomes after antibiotic megaspacer implantation in patients with severe chronic periprosthetic infections. 61
33179324 2021
23
Saving the lower limb with GlassBONEâ„¢ - Successful surgical revision of pseudarthrosis after infected open proximal tibia fracture type IIIC with bioactive glass grafting - A case report. 61
33426259 2021
24
Immediate replacement of bone flap after craniotomy for empyema in children. 61
32691196 2021
25
Risk of Complications With the Total Contact Cast in Diabetic Foot Disorders. 61
31888384 2021
26
Incidence of Odontogenic Disease in Patients With Pott's Puffy Tumor. 61
32890475 2021
27
Sequential breast implant infections due to Campylobacter fetus subsp. fetus. 61
33563526 2021
28
A study protocol for a Pilot Masked, Randomized Controlled Trial Evaluating Locally-applied Gentamicin versus Saline in Open Tibia Fractures (pGO-Tibia) in Dar es Salaam, Tanzania. 61
33568230 2021
29
Bacteria and antibiotic resistance detection in fractures of wild birds from wildlife rehabilitation centres in Spain. 61
33260016 2021
30
A Novel Low-Profile External Skeletal Fixator for Type IIIB Open Tibial Fractures: A Biomechanical and Clinical Pilot Study. 61
33595994 2021
31
Wide posterior gluteal-thigh propeller flap for reconstruction of perineal defects. 61
33030284 2021
32
Combined approach for intrapelvic abscess drainage among adults. 61
33364294 2021
33
Invasive diagnostic and therapeutic measures are unnecessary in patients with symptomatic van Neck-Odelberg disease (ischiopubic synchondrosis): a retrospective single-center study of 21 patients with median follow-up of 5 years. 61
33538214 2021
34
Improving Care and Outcomes for Pediatric Musculoskeletal Infections. 61
33414235 2021
35
Reconstruction of Tibia Fracture With Soft Tissue Defect. 61
33346537 2021
36
High-Dose Daptomycin and Clinical Applications. 61
33535792 2021
37
Mono vs. combo regimens with novel beta-lactam/beta-lactamase inhibitor combinations for the treatment of infections due to carbapenemase-producing Enterobacterales: insights from the literature. 61
33534065 2021
38
Value of antigranulocyte scintigraphy with Tc-99m-sulesomab in diagnosing combat-related infections of the musculoskeletal system. 61
30787111 2021
39
Management of Open Calcaneal Fractures with Medial Wounds by One-Stage Sequential Reduction and Frame Structure Fixation Using Percutaneous Kirschner Wires. 61
33403804 2021
40
Unusual complications of bone wax at the skull base. 61
33593449 2021
41
Treatment of Chronic Hematogenous Osteomyelitis in Children With Antibiotic Impregnated Calcium Sulphate. 61
33284138 2021
42
Microbiological diagnosis of suspected vertebral osteomyelitis with a focus on the yield of percutaneous needle biopsy: a 10-year cohort study. 61
32901378 2021
43
Pseudocarcinomatous Squamous Hyperplasia Involving Bone: A Diagnostic Pitfall Mimicking Squamous Cell Carcinoma. 61
32910020 2021
44
Psoriasis Associated With Tumor Necrosis Factor Inhibitors in Children With Inflammatory Diseases. 61
31646743 2021
45
Sternal mass caused by Mycobacterium tuberculosis in an immunocompetent young adult. 61
33580959 2021
46
Marjolin's ulcer of the forearm from 30-year-neglection of external fixator. 61
33592413 2021
47
Histopathologic findings in culture-positive secondary osteomyelitis. 61
33197866 2021
48
Mucormycosis originated total maxillary and cranial base osteonecrosis: a possible misdiagnosis to malignancy. 61
33579255 2021
49
IgG4-related disease presenting as otogenic skull base osteomyelitis. 61
32111411 2021
50
Opportunities for Stewardship in the Transition From Intravenous to Enteral Antibiotics in Hospitalized Pediatric Patients. 61
33496660 2021
Sources

Variations for Osteomyelitis

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Expression for Osteomyelitis

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Search GEO for disease gene expression data for Osteomyelitis.
Sources

Pathways for Osteomyelitis

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Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.13 TNFSF11 TNF TLR2 PPP3CA NLRP3 IL6
2
ERK Signaling 63
Show member pathways
 13.89 TNFSF11 TNF IL6 IL1B IL1A IL10
3
PEDF Induced Signaling 63
Show member pathways
 13.81 TNFSF11 TNF PPP3CA IL6 IL1RN IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.63 TNF IL6 IL1B IL1A IL10 IFNGR1
5
Akt Signaling 63
Show member pathways
 13.52 TNFSF11 TNF TLR2 IL6 IL1B IL1A
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.5 TNFSF11 TNF IL6 IL1RN IL1B IL1A
7
PAK Pathway 63
Show member pathways
 13.43 TNFSF11 TNF IL6 IL1B IL1A IL10
8
IL-2 Pathway 63
Show member pathways
 13.3 TNF TLR2 PPP3CA IL1B IL1A IFNGR1
9
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.21 TNF TLR2 IL6 IL1B IL10 IFNGR1
10
Human cytomegalovirus infection 36
Show member pathways
 13.06 TNF TLR2 PPP3CA IL6 IL1B IFNGR1
11
Allograft rejection 36 1
Show member pathways
 12.99 TNF IL6 IL1B IL1A IL10 IFNG
12
Herpes simplex virus 1 infection 36
12.91 TNF TLR2 IL6 IL1B IFNGR1 IFNG
13
Measles 36
Show member pathways
 12.9 TNF TLR2 NLRP3 IL6 IL1B IL1A
14
Salmonella infection (KEGG) 36
Show member pathways
 12.89 TNF TLR2 NLRP3 IL6 IL1B CXCL8
15
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.86 TNF TLR2 NLRP3 IL6 IL1RN IL1B
16
MAPK signaling pathway 36 1
12.83 TNF PPP3CA IL1B IL1A CASP1
17
NF-KappaB Family Pathway 63
Show member pathways
 12.82 TNF TLR2 IL6 IL1B IL1A BMP2
18
4-1BB Pathway 63
Show member pathways
 12.75 TNF IL1B IL1A IFNGR1 IFNG
19
TRAF Pathway 63
Show member pathways
 12.75 TNFSF11 TNF TLR2 PPP3CA IL1B IL1A
20
NF-kappaB Signaling 4
12.73 TNFSF11 TNF TLR2 PPP3CA IL1RN IL1B
21
Immune response NFAT in immune response 23
Show member pathways
 12.72 TNF PPP3CA IL10 IFNGR1 IFNG
22
T cell receptor signaling pathway 36
Show member pathways
 12.72 TNF TLR2 PPP3CA IL6 IL1B IL1A
23
Th17 cell differentiation 36
Show member pathways
 12.7 TNF TLR2 PPP3CA IL6 IL1B IL1A
24
Immune response IL-23 signaling pathway 23
Show member pathways
 12.68 TNF IL6 IL1B IL10 IFNG
25
RANK Signaling in Osteoclasts 63
Show member pathways
 12.53 TNFSF11 PPP3CA IL10 CTSK ACP5
26
Shigellosis 36
12.52 TNF NLRP3 IL1B CXCL8 CASP1
27
IL-17 Family Signaling Pathways 64
Show member pathways
 12.5 TNF TLR2 IL6 IL1B IFNG CXCL8
28
Toll Comparative Pathway 63
Show member pathways
 12.5 TNF IL6 IL1B IL1A IFNGR1 IFNG
29
Folate Metabolism 1
Show member pathways
 12.46 TNF IL6 IL1B IFNG CRP
30
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.44 TNF IL6 IL1B IL1A IL10 IFNG
31
Toxoplasmosis 36
Show member pathways
 12.44 TNF TLR2 IL1B IL1A IL10 IFNGR1
32
NOD-like receptor signaling pathway 36
12.41 TNF NLRP3 IL6 IL1B CXCL8 CASP1
33
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.4 TNF IL6 IL10 CXCL8
34
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.39 TNF TLR2 IL6 IL1A CXCL8
35
C-type lectin receptor signaling pathway 36
Show member pathways
 12.39 TNF PPP3CA NLRP3 IL6 IL1B IL10
36
IL-1 signaling pathway 1
Show member pathways
 12.37 IL1RN IL1B IL1A CASP1
37
Necroptosis 36
Show member pathways
 12.37 TNF NLRP3 IL1B IL1A IFNGR1 IFNG
38
Bacterial infections in CF airways 23
Show member pathways
 12.35 TNF TLR2 IL6 IL1B IFNGR1 IFNG
39
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.34 TNF IL6 IL1RN IL1B IL1A IL10
40
Colorectal Cancer Metastasis 63
12.32 TNF TLR2 IL6 IFNGR1 IFNG
41
Cellular senescence (KEGG) 36
12.25 PPP3CA IL6 IL1A CXCL8
42
Yersinia infection 36
12.25 TNF NLRP3 IL6 IL1B IL10 CXCL8
43
Fluid shear stress and atherosclerosis 36
12.19 TNF IL1B IL1A IFNG
44
Interleukin-4 and 13 signaling 65
12.18 TNF IL6 IL1B IL1A IL10 CXCL8
45
Tuberculosis 36
12.17 TNF TLR2 PPP3CA IL6 IL1B IL1A
46
Adipogenesis 1
12.16 TNF LPIN2 IL6 BMP2
47
Spinal Cord Injury 1
12.16 TNF PPP3CA IL6 IL1B IL1A IFNG
48
Senescence and Autophagy in Cancer 1
12.14 IL6 IL1B IL1A IFNG CXCL8 BMP2
49
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.1 TNF IL6 IL10 IFNG
50
AGE-RAGE signaling pathway in diabetic complications 36
12.09 TNF IL6 IL1B IL1A CXCL8
Sources

GO Terms for Osteomyelitis

About this section

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 extracellular region GO:0005576 9.47 TNFSF11 TNF NLRP3 IL6 IL1RN IL1B
3 NLRP3 inflammasome complex GO:0072559 9.16 NLRP3 CASP1

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.37 TLR2 NLRP3 IL6 IL1RN IL1B IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TNFSF11 TNF TLR2 PPP3CA NLRP3 LPIN2
3 apoptotic process GO:0006915 10.19 TLR2 NLRP3 IL1B IL1A IFNG CASP1
4 negative regulation of cell proliferation GO:0008285 10.11 TLR2 IL6 IL1B IL1A IL10 CXCL8
5 negative regulation of gene expression GO:0010629 10.09 TNF PPP3CA IFNG CXCL8 BMP2
6 positive regulation of protein phosphorylation GO:0001934 10.03 TNF IL1B IFNG BMP2
7 response to lipopolysaccharide GO:0032496 10.01 TLR2 IL1B IL10 CASP1
8 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 IL6 CRP
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNFSF11 TNF TLR2 NLRP3 IL6 IL1B
10 inflammatory response GO:0006954 9.96 TNF TLR2 NLRP3 IL6 IL1RN IL1B
11 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR2 IL1B IFNG
12 regulation of insulin secretion GO:0050796 9.93 TNF IL6 IL1B IFNG
13 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR2 IL6 IL1A IFNGR1 IFNG
14 cellular response to lipopolysaccharide GO:0071222 9.92 TNF NLRP3 IL6 IL1B IL1A IL10
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IFNG
16 cellular response to organic cyclic compound GO:0071407 9.91 TNF IL1B BMP2
17 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL1RN IL10
18 positive regulation of interleukin-8 production GO:0032757 9.91 TNF TLR2 IL6 IL1B
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.9 TNF TLR2 IL1B
20 humoral immune response GO:0006959 9.9 TNF IL6 IFNG
21 immune response GO:0006955 9.9 TNFSF11 TNF TLR2 IL6 IL1RN IL1B
22 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.89 TNF NLRP3 CASP1
23 positive regulation of phagocytosis GO:0050766 9.88 TNF IL1B IFNG
24 positive regulation of epithelial to mesenchymal transition GO:0010718 9.88 IL6 IL1B BMP2
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF IL1B IFNG
26 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 TNFSF11 TNF PPP3CA IL6 IL1B IL10
27 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.87 TNF IL10 BMP2
28 acute-phase response GO:0006953 9.87 IL6 IL1RN CRP
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.86 TNF IL1B IL1A
30 positive regulation of chemokine production GO:0032722 9.86 TNF TLR2 IL6 IFNG
31 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR2 IL1B
33 positive regulation of vascular endothelial growth factor production GO:0010575 9.85 IL6 IL1B IL1A
34 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF NLRP3 IL6 IFNG CASP1
35 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR2 IL6 IL1B IL1A IFNG
36 microglial cell activation GO:0001774 9.84 TNF TLR2 IFNGR1 IFNG
37 negative regulation of neurogenesis GO:0050768 9.83 TNF IL6 IL1B
38 bone resorption GO:0045453 9.83 TNFSF11 CTSK ACP5
39 positive regulation of cytokine production GO:0001819 9.83 TNF IL1A IL10 IFNG CASP1
40 positive regulation of osteoclast differentiation GO:0045672 9.82 TNFSF11 TNF IFNG
41 positive regulation of amyloid-beta formation GO:1902004 9.82 TNF IFNGR1 IFNG
42 positive regulation of glial cell proliferation GO:0060252 9.81 TNF IL6 IL1B
43 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 TNF IL1B IFNG
44 astrocyte activation GO:0048143 9.8 TNF IFNGR1 IFNG
45 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
46 positive regulation of neuroinflammatory response GO:0150078 9.77 TNF IL6 IL1B
47 negative regulation of amyloid-beta clearance GO:1900222 9.77 TNF IFNGR1 IFNG
48 response to molecule of bacterial origin GO:0002237 9.76 TLR2 IL10 CXCL8
49 negative regulation of lipid storage GO:0010888 9.75 TNF IL6 CRP
50 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.74 TNF PPP3CA

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Osteomyelitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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