MCID: OST017
MIFTS: 65

Osteomyelitis

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 75 53 29 55 44 15 17 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:1019
ICD9CM 35 730.1 730.10
MeSH 44 D010019
SNOMED-CT 68 40970001
ICD10 33 M86 M86.9
UMLS 72 C0008707 C0029443

Summaries for Osteomyelitis

NIH Rare Diseases : 53 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to chronic recurrent multifocal osteomyelitis and toxic shock syndrome, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ceftriaxone and Norgestimate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 75 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1079)
# Related Disease Score Top Affiliating Genes
1 chronic recurrent multifocal osteomyelitis 33.8 LPIN2 IL1B FBLIM1 CASP1
2 toxic shock syndrome 32.1 TNF IL6 IL1B IL10 IFNG
3 spondylitis 31.4 TNF IL6 IL1RN
4 osteopetrosis, autosomal dominant 2 31.4 TNFSF11 CTSK ACP5
5 endocarditis 31.3 TNF IL6 IL10
6 exanthem 31.0 TNF IL6 IL1RN
7 aspergillosis 30.9 TNF IL10 IFNG
8 peripheral nervous system disease 30.7 TNF SPTLC1 IL6
9 immune deficiency disease 30.7 IL1A IL10 IFNGR1
10 otitis media 30.7 TNF IL6 IL1B IL10
11 crohn's colitis 30.6 TNF IL1B IFNG
12 synovitis 30.6 TNFSF11 TNF IL6 IL1RN IL1B
13 melioidosis 30.6 TNF IL6 IL10 IFNG
14 sarcoidosis 1 30.6 TNF IL1B IFNG
15 reactive arthritis 30.5 TNF IL10 IFNG
16 pneumonia 30.5 TNF IL6 IL1B IL10
17 meningitis 30.5 TNF IL6 IL1B IL10 IFNG
18 interferon gamma, receptor 1, deficiency 30.5 IFNGR1 IFNG
19 pulmonary tuberculosis 30.5 TNF IL10 IFNGR1 IFNG
20 acute respiratory distress syndrome 30.5 TNF IL6 IL1B
21 salmonellosis 30.5 IL1B IFNGR1 IFNG CASP1
22 lung disease 30.5 TNF IL6 IL1B IL10
23 juvenile rheumatoid arthritis 30.4 TNF IL6 IL1RN IL1B
24 gastroenteritis 30.4 TNF IL6 IL1B IL10
25 appendicitis 30.4 TNF IL6 IL1B IL10
26 peritonitis 30.4 TNF IL6 IL1B IL10
27 pyelonephritis 30.4 TNF IL6 IL1B IL10
28 radiculopathy 30.4 IL6 IL1A IL10
29 poliomyelitis 30.4 TNF IL10 IFNG
30 leprosy 3 30.3 TNF IL10 IFNG
31 lymphadenitis 30.3 TNF IL1B IL10 IFNGR1 IFNG
32 neuritis 30.3 TNF IL1B IFNG
33 pericarditis 30.3 TNF IL6 IL1RN IL1B IFNG
34 brucellosis 30.3 TNF IL6 IL1RN IL10 IFNG
35 mycobacterium tuberculosis 1 30.3 TNF IL10 IFNGR1 IFNG
36 bacterial meningitis 30.3 TNF IL6 IL1B IL10
37 osteonecrosis 30.3 TNFSF11 BMP2 ACP5
38 perinatal necrotizing enterocolitis 30.3 TNF IL6 IL1B
39 prostatitis 30.2 TNF IL6 IL1B IL10
40 acquired immunodeficiency syndrome 30.2 TNF IL6 IL1B IL10 IFNG
41 inflammatory bowel disease 30.1 TNF IL6 IL1B IL10 IFNG
42 q fever 30.1 TNF IL6 IL1B IL10 IFNG
43 rheumatic fever 30.1 TNF IL6 IL10
44 endosteal hyperostosis, autosomal dominant 30.1 TNFSF11 CTSK BMP2
45 sporotrichosis 30.1 IL10 IFNG
46 cerebral palsy 30.1 TNF IL6 IL1B
47 periodontitis, chronic 30.1 TNFSF11 IL6 IL1B
48 paracoccidioidomycosis 30.0 TNF IL6 IL10 IFNG
49 middle ear disease 30.0 TNF IL6 IL1B
50 autoimmune disease 30.0 TNF IL6 IL1B IL10 IFNG

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


bone pain, pain in limb

MGI Mouse Phenotypes related to Osteomyelitis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ANO5 BMP2 CASP1 CTSK IFNG IFNGR1
2 hematopoietic system MP:0005397 10.35 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
3 immune system MP:0005387 10.31 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
4 cardiovascular system MP:0005385 10.29 BMP2 CASP1 IFNG IFNGR1 IL10 IL1A
5 cellular MP:0005384 10.28 ANO5 BMP2 CASP1 CTSK FBLIM1 IFNG
6 growth/size/body region MP:0005378 10.24 BMP2 CTSK IFNG IL10 IL1B IL1RN
7 mortality/aging MP:0010768 10.18 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
8 digestive/alimentary MP:0005381 10.11 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
9 integument MP:0010771 10.1 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
10 craniofacial MP:0005382 10.07 BMP2 CTSK IFNG IL10 IL1B TNF
11 nervous system MP:0003631 9.93 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
12 neoplasm MP:0002006 9.91 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
13 muscle MP:0005369 9.87 ANO5 IFNG IL10 IL6 PPP3CA TNF
14 reproductive system MP:0005389 9.73 ANO5 BMP2 CASP1 IFNG IFNGR1 IL10
15 skeleton MP:0005390 9.36 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 308)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
2
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
3
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
4
Metronidazole Approved Phase 4 443-48-1 4173
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
9
Teicoplanin Approved, Investigational Phase 4 61036-62-2
10
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
11
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
12
Cefazolin Approved Phase 4 25953-19-9 656510 33255
13
Nafcillin Approved, Investigational Phase 4 985-16-0, 147-52-4 8982
14
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
15
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
16
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
17
Vancomycin Approved Phase 4 1404-90-6 441141 14969
18
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
19
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
20
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
21 Antiparasitic Agents Phase 4
22 Topoisomerase Inhibitors Phase 4
23 Antiprotozoal Agents Phase 4
24 Contraceptives, Oral Phase 4
25 Contraceptive Agents Phase 4
26 Contraceptives, Oral, Combined Phase 4
27 Norgestimate, ethinyl estradiol drug combination Phase 4
28 Estradiol 3-benzoate Phase 4
29 Estradiol 17 beta-cypionate Phase 4
30 Cytochrome P-450 CYP3A Inducers Phase 4
31 Cytochrome P-450 Enzyme Inducers Phase 4
32 Nucleic Acid Synthesis Inhibitors Phase 4
33 Vitamin B9 Phase 4
34 Folate Phase 4
35 Vitamin B Complex Phase 4
36 Micronutrients Phase 4
37 Trace Elements Phase 4
38 Vitamins Phase 4
39 Nutrients Phase 4
40 Vitamin B2 Phase 4
41 Dermatologic Agents Phase 4
42 Photosensitizing Agents Phase 4
43 Floxacillin Phase 4
44 penicillins Phase 4
45 Penicillin G Benzathine Phase 4
46 Penicillin G Procaine Phase 4
47
Tazobactam Approved Phase 3 89786-04-9 123630
48
Piperacillin Approved Phase 3 66258-76-2 43672
49
Ertapenem Approved, Investigational Phase 3 153832-46-3 150610
50
Tigecycline Approved Phase 3 220620-09-7 5282044

Interventional clinical trials:

(show top 50) (show all 152)
# Name Status NCT ID Phase Drugs
1 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
3 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
4 Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study Completed NCT02123628 Phase 4 duration of the antibiotic therapy
5 Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
6 Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
7 CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
8 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
9 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
10 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
11 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
12 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
13 Comparison of Medical and Medical-surgical Management of Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
14 A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers Withdrawn NCT00338702 Phase 4
15 Platelet Gel for Digital Ulcers in Patients With SSc: a Randomized Controlled Trial Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
16 A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline Versus Ertapenem for the Treatment of Foot Infections in Subjects With Diabetes Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
17 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
18 A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Efficacy and Safety of Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium in the Treatment of Diabetic Foot Infections in Chinese Adults Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
19 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
20 A Phase III, Multicenter, Open-Label Study To Evaluate The Efficacy, Safety, and Pharmacokinetics of Gammaplex® in Primary Immunodeficiency Diseases Completed NCT00278954 Phase 3
21 A Phase II/III Study of the Safety and Efficacy of NC-503 in Patients Suffering From Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3 NC-503 (Anti-amyloidotic (AA) Agent)
22 Effectiveness and Safety of an Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers of the Fore Foot: a Prospective Randomised Pilot Study Completed NCT01586481 Phase 3
23 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
24 Double Blind, Randomized, Placebo Controlled Clinical Trial for the Treatment of Diabetic Foot Ulcers, Using a Nitric Oxide Releasing Patch: PATHON Completed NCT00428727 Phase 3 Controlled nitric oxide releasing patch;placebo patch
25 Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
26 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Active, not recruiting NCT03174366 Phase 3 Denosumab
27 Randomised Control Study for Inactive Chronic Hepatitis B Patients With Low Viral Load, With Peg-Interferon (INACTIVE) Active, not recruiting NCT02992704 Phase 2, Phase 3 Peginterferon Alfa-2A
28 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
29 A Randomized, Open-Label, Multi-Center Study to Compare the Safety and Efficacy of Apligraf Versus Standard Therapy (i.e., Saline Moistened Dressing Regimen) in the Treatment of Diabetic (Primarily Neuropathic) Foot Ulcers Terminated NCT00512538 Phase 3
30 A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to Gram-Positive Organisms Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
31 Arthrotomy With Irrigation and Debridement Versus Serial Arthrocentesis as Treatment for Septic Arthritis in Adults Withdrawn NCT00313365 Phase 3
32 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
33 ASSESSMENT OF CELLULAR INFLAMMATION FOLLOWING ACUTE MYOCARDIAL INFARCTION Application Of Ultrasmall Superparamagnetic Particles Of Iron Oxide Unknown status NCT01995799 Phase 2
34 A Phase 2, Single-center, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-Positive Organisms Completed NCT02685033 Phase 2 Dalbavancin;Comparator
35 A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthetic Hip or Knee Joint Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
36 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
37 Initial Safety and Pharmacokinetics Trial of Immune Globulin to Staphylococcus Aureus Capsule Polysaccharide (Altastaph) in Subjects With S. Aureus Bacteremia and Persistent Fever Completed NCT00063089 Phase 1, Phase 2 S. aureus Immune Globulin Intravenous (Human) 5%
38 Topic Insulin Accelerates Wound in Diabetes Completed NCT01295177 Phase 1, Phase 2 topic cream insulin
39 Phase I/II Open Label FIH Single Center Clinical Study Aimed to Evaluate the Safety and the Efficacy of BonoFill in Reconstructing the Bone. Completed NCT02153268 Phase 1, Phase 2
40 The Use of Antimicrobial Synthetic Bone Grafts in the Treatment of Bone Infection Recruiting NCT03945864 Phase 1, Phase 2
41 Phase 1/2 Trial of Ceftaroline for the Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Recruiting NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
42 Phase I/II Open Label First in Human Single Center Clinical Study Aimed to Evaluate the Safety and Efficacy of BonoFill-II in Reconstructing Maxillofacial Bone Recruiting NCT02842619 Phase 1, Phase 2
43 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
44 Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease Recruiting NCT02813629 Phase 2
45 Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a Neonatal Intensive Care Unit Recruiting NCT02967432 Phase 2 Mupirocin Topical Ointment;Petroleum Jelly
46 Phase 2a Randomized, Single-Blind, Placebo-Controlled, 12-week Escalating Dose Study to Assess the Safety, Tolerability and Clinical Activity of 3 Concentrations of Locally Applied MBN-101 to Infected Bone Sites Active, not recruiting NCT02436876 Phase 2 MBN-101
47 A Phase 2, Multicenter, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-positive Organisms Terminated NCT03091439 Phase 2 Dalbavancin;Standard of Care
48 Exploration of the Use of [124I]FIAU Positron Emission Tomography-Computed Tomography Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection. Terminated NCT01764919 Phase 2
49 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) Terminated NCT02168816 Phase 2 Intravenous Antibacterial Agent;Oral Antibacterial Agent
50 Autologous Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Distraction Osteogenesis in Patients With Limb-length Discrepancy Completed NCT01210950 Phase 1

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Aztreonam
Cephalexin
Ciprofloxacin
Clindamycin
Cloxacillin

Cochrane evidence based reviews: osteomyelitis

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 29

Anatomical Context for Osteomyelitis

MalaCards organs/tissues related to Osteomyelitis:

41
Bone, Skin, Bone Marrow, Testes, Spinal Cord, Heart, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

19
Bone, Bone Marrow

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 21199)
# Title Authors PMID Year
1
Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency. 9 38
19880337 2010
2
Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein-2 for vertebral osteomyelitis. 9 38
17233287 2007
3
RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. 9 38
17032395 2006
4
Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. 9 38
15872059 2005
5
[The study of the antioxidant enzymes in erythrocytes in lung diseases]. 9 38
12838770 2003
6
Genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. 9 38
11865431 2002
7
Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. 9 38
11792597 2002
8
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. 9 38
11139207 2001
9
Antimicrobial treatment of chronic osteomyelitis. 9 38
10101310 1999
10
Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. 9 38
9581562 1997
11
The effect of growth temperature on Staphylococcus aureus binding to type I collagen. 9 38
7715422 1994
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 9 38
8382334 1993
13
Preparation, in vitro release and antibacterial activity evaluation of rifampicin and moxifloxacin-loaded poly(D,L-lactide-co-glycolide) microspheres. 38
30892092 2019
14
Early diagnosis of jaw osteomyelitis by easy digitalized panoramic analysis. 38
30800645 2019
15
Imaging modalities for drug-related osteonecrosis of the jaw (2), Overview of the position paper on medication-related osteonecrosis of the jaw and the current status of the MRONJ in Japan. 38
30949254 2019
16
Novel insight into the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ). 38
31193410 2019
17
Development of bone regeneration strategies using human periosteum-derived osteoblasts and oxygen-releasing microparticles in mandibular osteomyelitis model of miniature pig. 38
31116505 2019
18
Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating. 38
31349530 2019
19
Percutaneous image-guided bone biopsy of osteomyelitis in the foot and pelvis has a low impact on guiding antibiotics management: a retrospective analysis of 60 bone biopsies. 38
30778640 2019
20
Sternoclavicular septic arthritis caused by Staphylococcus aureus: excellent results from medical treatment and limited surgery. 38
31355687 2019
21
Salmonella enterica Serovar Panama, an Understudied Serovar Responsible for Extraintestinal Salmonellosis Worldwide. 38
31262982 2019
22
The microbiology of chronic osteomyelitis: Changes over ten years. 38
31319142 2019
23
Sensitivity of Serologic Testing for Dogs Diagnosed with Coccidioidomycosis on Histology: 52 Cases (2012-2013). 38
31433229 2019
24
Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen. 38
30484215 2019
25
Role of 18F-flurodeoxyglucose in orthopaedic implant-related infection: review of literature and experience. 38
31365498 2019
26
Radiological diagnosis of chronic recurrent multifocal osteomyelitis using whole-body MRI-based lesion distribution patterns. 38
31280883 2019
27
Commentary on: radiological diagnosis of chronic recurrent multifocal osteomyelitis using whole-body MRI-based lesion distribution patterns. 38
31272598 2019
28
Assessing the fusion of the ischiopubic synchondrosis using predictive modeling. 38
30701593 2019
29
Clinical significance of IgG4 in sinonasal and skull base inflammatory pseudotumor. 38
31203383 2019
30
Mycotic Pseudoaneurysm of Internal Carotid Artery Induced by Skull Base Osteomyelitis. 38
31348132 2019
31
Antisense yycG Regulation of Antibiotic Sensitivity of Methicillin-Resistant Staphylococcus aureus in Chronic Osteomyelitis. 38
31038392 2019
32
Histological score for degrees of severity in an implant-associated infection model in mice. 38
31020411 2019
33
The routes of infection spread in central skull-base osteomyelitis and the diagnostic role of CT and MRI scans. 38
31370785 2019
34
The Effect of Withholding Antibiotics Prior to Bone Biopsy in Patients With Suspected Osteomyelitis: A Meta-analysis of the Literature. 38
31356178 2019
35
An open-label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis. 38
31376297 2019
36
Amphotericin B Induction with Voriconazole Consolidation as Salvage Therapy for FKS-Associated Echinocandin Resistance in Candida glabrata Septic Arthritis and Osteomyelitis. 38
31345844 2019
37
Double-stranded RNA is a novel molecular target in osteomyelitis pathogenesis: a translational avian model for human bacterial chondronecrosis with osteomyelitis. 38
31381888 2019
38
Interferon Gamma-1b Does Not Increase Markers of Bone Resorption in Autosomal Dominant Osteopetrosis. 38
30889272 2019
39
Diagnostic challenges in infective endocarditis: is PET/CT the solution? 38
30847769 2019
40
Asymptomatic Bone Marrow Edema Detected by 67Ga Scintigraphy. 38
31274623 2019
41
The role of reconstructive microsurgery in treating lower-extremity chronic wounds. 38
31148396 2019
42
Autologous lipotransfer for bone defects secondary to osteomyelitis: A report of a novel method and systematic review of the literature. 38
30916475 2019
43
Significant Suppression of Staphylococcus aureus Colonization on Intramedullary Ti6Al4V Implants Surface-Grafted with Vancomycin-Bearing Polymer Brushes. 38
31313901 2019
44
A rare case: sclerosing osteomyelitis of the frontal bone. 38
31129705 2019
45
Primary sternal osteomyelitis due to coagulase-negative staphylococci. 38
31427040 2019
46
Treatment of bone and joint infections caused by Enterobacter cloacae with a fluoroquinolone-cotrimoxazole combination. 38
31096009 2019
47
Robotic harvesting of the omental flap: a case report and mini-review of the use of robots in reconstructive surgery. 38
30911884 2019
48
[Histopathological Charcot score on intraoperative tissue samples from the foot : A prospective investigation]. 38
31278600 2019
49
Physeal separation in pediatric osteomyelitis. 38
31093724 2019
50
Current Status of Molecular Imaging of Infection: A Primer. 38
31012760 2019

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TNFSF11 TNF PPP3CA IL6 IL1RN IL1B
2
Show member pathways
13.74 TNFSF11 TNF PPP3CA IL6 IL1RN IL1B
3
Show member pathways
13.58 TNF IL6 IL1B IL1A IL10 IFNGR1
4
Show member pathways
13.45 TNFSF11 TNF IL6 IL1RN IL1B IL1A
5
Show member pathways
13.44 TNFSF11 TNF IL6 IL1B IL1A IL10
6
Show member pathways
13.36 TNFSF11 TNF IL6 IL1B IL1A IL10
7
Show member pathways
13.2 TNF IL6 IL1B IL10 IFNGR1 IFNG
8
Show member pathways
12.98 TNF PPP3CA IL6 IL1B IL1A IL10
9 12.81 TNF PPP3CA IL1B IL1A CASP1
10
Show member pathways
12.81 TNF IL6 IL1B IFNG CASP1
11
Show member pathways
12.76 TNF IL6 IL1B IL1A BMP2
12
Show member pathways
12.73 TNF IL1B IL1A IFNGR1 IFNG
13
Show member pathways
12.7 TNFSF11 TNF PPP3CA IL1B IL1A CASP1
14
Show member pathways
12.69 TNF PPP3CA IL10 IFNGR1 IFNG
15 12.66 TNFSF11 TNF PPP3CA IL1RN IL1B IL10
16
Show member pathways
12.66 TNF PPP3CA IL6 IL1B IL1A IL10
17
Show member pathways
12.65 TNF IL6 IL1B IL10 IFNG
18
Show member pathways
12.65 TNF PPP3CA IL6 IL1B IL1A IL10
19
Show member pathways
12.53 TNF PPP3CA IFNGR1 IFNG
20
Show member pathways
12.5 TNFSF11 PPP3CA IL10 CTSK ACP5
21
Show member pathways
12.44 TNF IL6 IL1B IL1A IFNGR1 IFNG
22
Show member pathways
12.42 IL6 IL10 IFNGR1 IFNG
23
Show member pathways
12.38 TNF IL6 IL1B IFNG
24
Show member pathways
12.38 TNF IL6 IL1B IFNG
25
Show member pathways
12.38 TNF IL1B IL1A IL10 IFNGR1 IFNG
26
Show member pathways
12.38 TNF IL6 IL1B IL1A IL10 IFNG
27
Show member pathways
12.35 IL1RN IL1B IL1A CASP1
28
Show member pathways
12.33 TNF IL6 IL1RN IL1B IL1A
29
Show member pathways
12.33 TNF IL1B IL1A IFNGR1 IFNG CASP1
30
Show member pathways
12.32 TNF PPP3CA IL6 IL1B IL10 CASP1
31
Show member pathways
12.29 TNF IL6 IL1B IFNGR1 IFNG
32 12.28 TNF IL6 IL1RN IL1B IL1A IL10
33 12.24 TNF IL6 IFNGR1 IFNG
34 12.17 TNF IL1B IL1A IFNG
35
Show member pathways
12.17 TNF IL6 IL1B IL10 IFNGR1 IFNG
36
Show member pathways
12.15 IL6 IL1B IL1A IL10 IFNGR1 IFNG
37 12.14 TNF LPIN2 IL6 BMP2
38
Show member pathways
12.12 TNF IL6 IL1B IFNG
39 12.12 TNF IL6 IL1B IL1A IL10
40 12.11 TNF PPP3CA IL6 IL1B IL1A IL10
41 12.1 TNF PPP3CA IL6 IL1B IL1A IFNG
42 12.08 IL6 IL1B IL1A IFNG BMP2
43 12.07 TNF IL6 IL10 IFNG
44 12.05 TNF IL6 IL1B IL10 IFNG
45 12 TNF IL6 IL1B IL1A
46 11.99 TNF IL6 IL1B IL1A
47 11.97 IL6 IFNGR1 IFNG
48 11.96 IL6 IL10 IFNGR1 IFNG
49 11.94 TNFSF11 TNF IL1B
50 11.9 TNF IFNG BMP2

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 extracellular space GO:0005615 9.32 TNFSF11 TNF IL6 IL1RN IL1B IL1A

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 TNF PPP3CA IFNG BMP2
2 positive regulation of protein phosphorylation GO:0001934 9.96 TNF IL1B IFNG BMP2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNFSF11 TNF IL6 IL1B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TNFSF11 TNF IL1RN IL1B CASP1
5 defense response to Gram-positive bacterium GO:0050830 9.89 TNF IL6 ACP5
6 ossification GO:0001503 9.88 TNFSF11 BMP2 ACP5
7 positive regulation of JNK cascade GO:0046330 9.87 TNFSF11 TNF IL1RN IL1B
8 cellular response to organic cyclic compound GO:0071407 9.86 TNF IL1B BMP2
9 immune response GO:0006955 9.86 TNFSF11 TNF IL6 IL1RN IL1B IL1A
10 regulation of insulin secretion GO:0050796 9.85 TNF IL1B IFNG
11 cellular response to lipopolysaccharide GO:0071222 9.85 TNF IL6 IL1RN IL1B IL10 CASP1
12 humoral immune response GO:0006959 9.84 TNF IL6 IFNG
13 interleukin-1-mediated signaling pathway GO:0070498 9.83 IL1RN IL1B IL1A
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B IFNG
15 positive regulation of interleukin-6 production GO:0032755 9.81 TNF IL6 IL1RN IL1B
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 TNF IL1B IL1A
17 positive regulation of cytokine secretion GO:0050715 9.78 TNF IL1A IL10
18 negative regulation of neurogenesis GO:0050768 9.77 TNF IL6 IL1B
19 bone resorption GO:0045453 9.76 TNFSF11 CTSK ACP5
20 positive regulation of gene expression GO:0010628 9.76 TNFSF11 TNF PPP3CA IL6 IL1B IL1A
21 positive regulation of osteoclast differentiation GO:0045672 9.75 TNFSF11 TNF IFNG
22 positive regulation of glial cell proliferation GO:0060252 9.73 TNF IL6 IL1B
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 TNF IL1B IFNG
24 regulation of osteoclast differentiation GO:0045670 9.71 TNFSF11 TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.71 TNF IL10
26 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNGR1 IFNG
27 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.71 IL1B IL1A
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 TNF IL1B IL10
29 negative regulation of interleukin-12 production GO:0032695 9.7 IL10 ACP5
30 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL1RN IL10
31 negative regulation of lipid storage GO:0010888 9.69 TNF IL6
32 positive regulation of chemokine biosynthetic process GO:0045080 9.68 TNF IL1B
33 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
34 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
35 ectopic germ cell programmed cell death GO:0035234 9.67 IL1B IL1A
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 TNF IL10
37 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
38 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL6 IL1RN
39 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
40 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
41 receptor biosynthetic process GO:0032800 9.62 TNF IL10
42 response to glucocorticoid GO:0051384 9.62 TNF IL6 IL1RN IL10
43 fever generation GO:0001660 9.61 IL1B IL1A
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.6 TNF IFNG
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IL1B IFNG
46 positive regulation of DNA-binding transcription factor activity GO:0051091 9.43 TNFSF11 TNF PPP3CA IL6 IL1B IL10
47 positive regulation of astrocyte differentiation GO:0048711 9.4 BMP2
48 positive regulation of JUN kinase activity GO:0043507 9.33 TNF
49 cytokine-mediated signaling pathway GO:0019221 9.28 TNFSF11 TNF IL6 IL1RN IL1B IL1A
50 chronic inflammatory response to antigenic stimulus GO:0002439 9.13 TNF

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TNFSF11 TNF IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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