MCID: OST017
MIFTS: 64

Osteomyelitis

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 74 52 29 54 43 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1019
ICD9CM 34 730.1 730.10
MeSH 43 D010019
SNOMED-CT 67 40970001
ICD10 32 M86 M86.9
UMLS 71 C0008707 C0029443

Summaries for Osteomyelitis

NIH Rare Diseases : 52 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise , or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system . The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues . This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue.

MalaCards based summary : Osteomyelitis is related to sapho syndrome and chronic recurrent multifocal osteomyelitis, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Metronidazole and Moxifloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 74 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1243)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 33.8 LPIN2 IL1RN CXCL8
2 chronic recurrent multifocal osteomyelitis 33.7 TNFSF11 TNF NLRP3 LPIN2 IL6 IL1RN
3 mycobacterium fortuitum 33.1 IFNGR1 CXCL8
4 osteopetrosis 32.6 TNFSF11 TNF CTSK ACP5
5 chronic granulomatous disease 32.5 TNF IL1B IFNG CXCL8 CASP1
6 toxic shock syndrome 31.6 TNF TLR4 TLR2 IL6 IL1RN IL1B
7 cellulitis 31.6 TNF IL6 IL10
8 septic arthritis 31.3 TLR4 TLR2 PPP3CA IFNG CXCL8
9 haemophilus influenzae 31.2 TNF TLR2 CXCL8
10 necrotizing fasciitis 31.1 IL6 IL1RN CXCL8
11 cryptococcosis 31.1 TNF IL10 IFNG
12 chickenpox 31.0 TNF IL6 IL10 IFNG
13 neurofibromatosis, type ii 31.0 TNF TLR2 IL6 IL1RN CXCL8
14 spinal cord injury 31.0 TNF IL6 CXCL8
15 endocarditis 31.0 TNF TLR2 IL6 IL10 IFNG CXCL8
16 infective endocarditis 31.0 TNF TLR2 IL6
17 pustulosis of palm and sole 31.0 TNF LPIN2 IL1RN CXCL8
18 osteonecrosis 31.0 TNFSF11 TNF IL10 BMP2 ACP5
19 fasciitis 30.9 TNF IL6 IL1RN IFNG CXCL8
20 myositis 30.9 TNF IL6 IL1B IFNG CXCL8
21 lung abscess 30.9 TNF IL6 IFNG
22 spondylitis 30.9 TNFSF11 TNF IL6 IL1RN IL10 IFNG
23 mycobacterium chelonae 30.9 TLR2 CXCL8
24 sarcoidosis 1 30.9 TNF IL1RN IL1B IFNG
25 smallpox 30.8 TNF IL1RN IL1B IFNG
26 pyoderma 30.8 TNF NLRP3 IL1RN CXCL8
27 immune deficiency disease 30.8 TNF IL6 IL10 IFNGR1 IFNG
28 vascular disease 30.8 TNF TLR4 IL6 IL10 IFNG
29 myelitis 30.8 TNF IL6 IL10 CXCL8
30 pyoderma gangrenosum 30.8 TNF NLRP3 IL1RN CXCL8
31 mycobacterium marinum 30.7 TLR2 CXCL8
32 synovitis 30.7 TNFSF11 TNF IL6 IL1RN IL1B CXCL8
33 sporotrichosis 30.7 TNF IL10 IFNG
34 pericarditis 30.6 TNF IL6 IL1RN IL1B IFNG CXCL8
35 crohn's colitis 30.6 TNF IL1B IFNG CXCL8
36 mycobacterium kansasii 30.6 TLR2 NLRP3 CXCL8
37 aortitis 30.6 TNF IL6 IL1RN
38 encephalitis 30.6 TNF IL6 IL1B IL10
39 poliomyelitis 30.6 TNF IL10 IFNG
40 exanthem 30.6 TNF NLRP3 IL6 IL1RN IL10 CXCL8
41 cervical adenitis 30.6 NLRP3 IL1RN IL1B
42 mammary paget's disease 30.5 TNFSF11 CTSK ACP5
43 bone resorption disease 30.5 TNFSF11 TNF IL6 CTSK BMP2 ACP5
44 radiculopathy 30.5 IL6 IL10 CXCL8 BMP2
45 interferon gamma, receptor 1, deficiency 30.5 IFNGR1 IFNG
46 purpura 30.5 TNF IL6 IL10
47 endophthalmitis 30.5 TNF TLR2 IL6 CXCL8
48 osteoarthritis 30.5 TNFSF11 TNF IL6 IL1RN IL1B CXCL8
49 endosteal hyperostosis, autosomal dominant 30.5 TNFSF11 CTSK BMP2 ACP5
50 prosthetic joint infection 30.5 TLR4 TLR2 IL6 IL1B

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


bone pain, pain in limb

MGI Mouse Phenotypes related to Osteomyelitis:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.47 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
2 homeostasis/metabolism MP:0005376 10.45 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
3 immune system MP:0005387 10.44 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
4 cellular MP:0005384 10.4 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
5 growth/size/body region MP:0005378 10.39 BMP2 CTSK IFNG IL10 IL1B IL1RN
6 cardiovascular system MP:0005385 10.37 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
7 mortality/aging MP:0010768 10.34 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
8 digestive/alimentary MP:0005381 10.31 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
9 integument MP:0010771 10.27 CASP1 IFNG IFNGR1 IL10 IL1B IL1RN
10 endocrine/exocrine gland MP:0005379 10.26 CASP1 CTSK FBLIM1 IFNG IFNGR1 IL10
11 nervous system MP:0003631 10.2 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
12 craniofacial MP:0005382 10.12 BMP2 CTSK IFNG IL10 IL1B TNF
13 liver/biliary system MP:0005370 10.11 IFNG IFNGR1 IL10 IL6 LPIN2 NLRP3
14 limbs/digits/tail MP:0005371 10.08 BMP2 CTSK FBLIM1 IL10 NLRP3 TLR4
15 neoplasm MP:0002006 10.07 CASP1 IFNG IFNGR1 IL10 IL1B IL6
16 muscle MP:0005369 10.01 IFNG IL10 IL6 PPP3CA TLR2 TLR4
17 reproductive system MP:0005389 10 BMP2 CASP1 CTSK IFNG IFNGR1 IL10
18 renal/urinary system MP:0005367 9.86 CASP1 IFNG IFNGR1 IL6 NLRP3 PPP3CA
19 respiratory system MP:0005388 9.56 CTSK IFNG IL10 IL6 TLR2 TLR4
20 skeleton MP:0005390 9.5 BMP2 CTSK FBLIM1 IFNG IFNGR1 IL10

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 305)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4 443-48-1 4173
2
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
5
Polyestradiol phosphate Approved Phase 4 28014-46-2
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
9
Teicoplanin Approved, Investigational Phase 4 61036-62-2
10
Cefazolin Approved Phase 4 25953-19-9 656510 33255
11
Nafcillin Approved, Investigational Phase 4 147-52-4, 985-16-0 8982
12
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
13
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
14
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
15
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
16
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
17
Vancomycin Approved Phase 4 1404-90-6 441141 14969
18
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
19
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
20
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
21
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
22 Topoisomerase Inhibitors Phase 4
23 Antiparasitic Agents Phase 4
24 Antiprotozoal Agents Phase 4
25 Norgestimate, ethinyl estradiol drug combination Phase 4
26 Contraceptive Agents Phase 4
27 Estradiol 17 beta-cypionate Phase 4
28 Contraceptives, Oral, Combined Phase 4
29 Contraceptives, Oral Phase 4
30 Estradiol 3-benzoate Phase 4
31 Cytochrome P-450 CYP3A Inducers Phase 4
32 Vitamin B Complex Phase 4
33 Vitamin B9 Phase 4
34 Folate Phase 4
35 Coagulase Phase 4
36 Trace Elements Phase 4
37 Micronutrients Phase 4
38 Vitamins Phase 4
39 Nutrients Phase 4
40 Vitamin B2 Phase 4
41 Dermatologic Agents Phase 4
42 Photosensitizing Agents Phase 4
43 Floxacillin Phase 4
44 penicillins Phase 4
45 Penicillin G Benzathine Phase 4
46 Penicillin G Procaine Phase 4
47
Denosumab Approved Phase 3 615258-40-7
48
Piperacillin Approved Phase 3 66258-76-2 43672
49
Tazobactam Approved Phase 3 89786-04-9 123630
50
Tigecycline Approved Phase 3 220620-09-7 5282044

Interventional clinical trials:

(show top 50) (show all 157)
# Name Status NCT ID Phase Drugs
1 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
3 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
4 Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study Completed NCT02123628 Phase 4 duration of the antibiotic therapy
5 Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
6 Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
7 CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
8 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
9 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
10 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
11 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
12 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
13 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
14 Comparison of Medical and Medical-surgical Management of Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
15 A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers Withdrawn NCT00338702 Phase 4
16 Platelet Gel for Digital Ulcers in Patients With SSc: a Randomized Controlled Trial Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
17 A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline Versus Ertapenem for the Treatment of Foot Infections in Subjects With Diabetes Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
18 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
19 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Completed NCT03174366 Phase 3 Denosumab
20 A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Efficacy and Safety of Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium in the Treatment of Diabetic Foot Infections in Chinese Adults Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
21 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
22 A Phase III, Multicenter, Open-Label Study To Evaluate The Efficacy, Safety, and Pharmacokinetics of Gammaplex® in Primary Immunodeficiency Diseases Completed NCT00278954 Phase 3
23 A Phase II/III Study of the Safety and Efficacy of NC-503 in Patients Suffering From Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3 NC-503 (Anti-amyloidotic (AA) Agent)
24 Effectiveness and Safety of an Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers of the Fore Foot: a Prospective Randomised Pilot Study Completed NCT01586481 Phase 3
25 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
26 Double Blind, Randomized, Placebo Controlled Clinical Trial for the Treatment of Diabetic Foot Ulcers, Using a Nitric Oxide Releasing Patch: PATHON Completed NCT00428727 Phase 3 Controlled nitric oxide releasing patch;placebo patch
27 Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
28 Randomised Control Study for Inactive Chronic Hepatitis B Patients With Low Viral Load, With Peg-Interferon (INACTIVE) Active, not recruiting NCT02992704 Phase 2, Phase 3 Peginterferon Alfa-2A
29 A Multicenter Phase 3 Trial of Biotherapy Using Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU) Not yet recruiting NCT04176120 Phase 3
30 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
31 A Randomized Placebo-controlled Double-blinded Trial of the Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin Not yet recruiting NCT04104178 Phase 3 Clindamycin;Placebo
32 A Randomized, Open-Label, Multi-Center Study to Compare the Safety and Efficacy of Apligraf Versus Standard Therapy (i.e., Saline Moistened Dressing Regimen) in the Treatment of Diabetic (Primarily Neuropathic) Foot Ulcers Terminated NCT00512538 Phase 3
33 A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to Gram-Positive Organisms Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
34 Arthrotomy With Irrigation and Debridement Versus Serial Arthrocentesis as Treatment for Septic Arthritis in Adults Withdrawn NCT00313365 Phase 3
35 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
36 ASSESSMENT OF CELLULAR INFLAMMATION FOLLOWING ACUTE MYOCARDIAL INFARCTION Application Of Ultrasmall Superparamagnetic Particles Of Iron Oxide Unknown status NCT01995799 Phase 2
37 A Phase 2, Single-center, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-Positive Organisms Completed NCT02685033 Phase 2 Dalbavancin;Comparator
38 A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthetic Hip or Knee Joint Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
39 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
40 Initial Safety and Pharmacokinetics Trial of Immune Globulin to Staphylococcus Aureus Capsule Polysaccharide (Altastaph) in Subjects With S. Aureus Bacteremia and Persistent Fever Completed NCT00063089 Phase 1, Phase 2 S. aureus Immune Globulin Intravenous (Human) 5%
41 Topic Insulin Accelerates Wound in Diabetes Completed NCT01295177 Phase 1, Phase 2 topic cream insulin
42 Phase I/II Open Label FIH Single Center Clinical Study Aimed to Evaluate the Safety and the Efficacy of BonoFill in Reconstructing the Bone. Completed NCT02153268 Phase 1, Phase 2
43 The Use of Antimicrobial Synthetic Bone Grafts in the Treatment of Bone Infection Recruiting NCT03945864 Phase 1, Phase 2
44 Phase I/II Open Label First in Human Single Center Clinical Study Aimed to Evaluate the Safety and Efficacy of BonoFill-II in Reconstructing Maxillofacial Bone Recruiting NCT02842619 Phase 1, Phase 2
45 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
46 Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease Recruiting NCT02813629 Phase 2
47 Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a Neonatal Intensive Care Unit Recruiting NCT02967432 Phase 2 Mupirocin Topical Ointment;Petroleum Jelly
48 Phase 2a Randomized, Single-Blind, Placebo-Controlled, 12-week Escalating Dose Study to Assess the Safety, Tolerability and Clinical Activity of 3 Concentrations of Locally Applied MBN-101 to Infected Bone Sites Active, not recruiting NCT02436876 Phase 2 MBN-101
49 Phase 1/2 Trial of Ceftaroline for the Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Active, not recruiting NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
50 A Phase 2, Multicenter, Open-label, Randomized, Comparator-controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Known or Suspected to be Due to Gram-positive Organisms Terminated NCT03091439 Phase 2 Dalbavancin;Standard of Care

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ciprofloxacin

Cochrane evidence based reviews: osteomyelitis

Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 29

Anatomical Context for Osteomyelitis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

19
Bone, Bone Marrow

MalaCards organs/tissues related to Osteomyelitis:

40
Bone, Skin, Bone Marrow, Testes, Heart, Spinal Cord, Prostate

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 21630)
# Title Authors PMID Year
1
Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency. 54 61
19880337 2010
2
Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein-2 for vertebral osteomyelitis. 54 61
17233287 2007
3
RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. 54 61
17032395 2006
4
Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. 54 61
15872059 2005
5
[The study of the antioxidant enzymes in erythrocytes in lung diseases]. 54 61
12838770 2003
6
Genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. 54 61
11865431 2002
7
Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. 54 61
11792597 2002
8
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. 54 61
11139207 2001
9
Antimicrobial treatment of chronic osteomyelitis. 54 61
10101310 1999
10
Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. 54 61
9581562 1997
11
The effect of growth temperature on Staphylococcus aureus binding to type I collagen. 54 61
7715422 1994
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 54 61
8382334 1993
13
Bilateral End-Organ Endophthalmitis in Setting of Serratia marcescens Urosepsis on 18F-FDG PET/CT. 61
31876818 2020
14
Osteomyelitis following an undisplaced basal skull fracture. 61
32027641 2020
15
Which Preoperative Factors are Associated with Not Attaining Acceptable Levels of Pain and Function After TKA? Findings from an International Multicenter Study. 61
32039954 2020
16
Reduction of Radiation Dose and Scanning Time While Preserving Diagnostic Yield: A Comparison of Battery-Powered and Manual Bone Biopsy Systems. 61
32029464 2020
17
Outcome of different treatments for chronic diffuse sclerosing osteomyelitis of the mandible: a systematic review of published papers. 61
32035697 2020
18
Candida albicans skull base osteomyelitis due to malignant otitis externa: the role of echinocandin therapy associated with surgical debridement. 61
30981455 2020
19
Management of bone defects due to infected non-union or chronic osteomyelitis with autologous non-vascularized free fibular grafts. 61
31718793 2020
20
Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis. 61
31759168 2020
21
Invasive Salmonella Enteritidis infection complicated by bacterial meningitis and vertebral osteomyelitis shortly after influenza A infection in an immunocompetent young adult. 61
31445818 2020
22
IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2. 61
31713625 2020
23
Trauma-associated Pott's puffy tumor: an ophthalmologic perspective. 61
30773962 2020
24
Abbreviated MRI of the foot in patients with suspected osteomyelitis. 61
31463805 2020
25
Hydrogen sulfide promotes lipopolysaccharide-induced apoptosis of osteoblasts by inhibiting the AKT/NF-κB signaling pathway. 61
32037087 2020
26
Pediatric Musculoskeletal Infections. 61
31779837 2020
27
Incidence, types and outcomes of sternal wound infections after cardiac surgery in Saudi Arabia. A retrospective medical chart review. 61
32020152 2020
28
The Osteoarticular Infection in a Pediatric Emergency Setting: A Challenging Diagnosis. 61
31895291 2020
29
A Scoping Review on the Use of Antibiotic-Impregnated Beads and Applications to Vascular Surgery. 61
31736431 2020
30
Effects of isosorbide mononitrate loaded nanoparticles conjugated with anti-Staphylococcus aureus α-toxin on Staphylococcus aureus biofilms. 61
32010298 2020
31
Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway. 61
31431733 2020
32
Incidence of Bacterial Chondronecrosis with Osteomyelitis (Femoral Head Necrosis) Induced by a Model of Skeletal Stress and its Correlation with Subclinical Necrotic Enteritis. 61
32024196 2020
33
The role of soluble urokinase plasminogen activator receptor (suPAR) in the diagnostics of diabetic foot infection. 61
31713451 2020
34
Limb Salvage Rates and Functional Outcomes using a Longitudinal Slit Arteriotomy End to Side Anastomosis for Limb Threatening Defects in a High-risk Patient Population. 61
32039971 2020
35
Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics. 61
30772132 2020
36
Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review. 61
32008574 2020
37
The Emergent Evaluation and Treatment of Neck and Back Pain. 61
31757249 2020
38
Arthroscopic Treatment of Acute Septic Arthritis of the Hip Joint in Pediatric Patients Aged 10 Years or Younger. 61
31734041 2020
39
Subchondral lucencies of the proximal tibia in 17 horses. 61
32031290 2020
40
Bone and soft tissue infections in patients with diabetic foot. 61
31650327 2020
41
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. 61
31819212 2020
42
Metastatic infection during Staphylococcus aureus bacteremia. 61
31676266 2020
43
Hemicorporectomy - the ultimate solution of terminal pelvic sepsis. 61
31986986 2020
44
In vitro time-kill kinetics of dalbavancin against Staphylococcus spp. biofilms over prolonged exposure times. 61
31761480 2020
45
Correction to: Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis. 61
32014003 2020
46
Skull base osteomyelitis: clinical and radiologic analysis of a rare and multifaceted pathological entity. 61
32036506 2020
47
Atherogenic Index of Plasma: A Potential Biomarker for Clinical Diagnosis of Diabetic Foot Osteomyelitis. 61
31369351 2020
48
Risk factors associated with recurrence of extremity osteomyelitis treated with the induced membrane technique. 61
31771787 2020
49
Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis. 61
32024700 2020
50
Transient osteomyelitis of the distal radius in a three-year-old patient. 61
31663320 2020

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 TNFSF11 TNF TLR4 TLR2 PPP3CA NLRP3
2
Show member pathways
13.8 TNFSF11 TNF TLR4 PPP3CA IL6 IL1RN
3
Show member pathways
13.6 TNF IL6 IL1B IL10 IFNGR1 IFNG
4
Show member pathways
13.52 TNFSF11 TNF TLR4 TLR2 IL6 IL1B
5
Show member pathways
13.5 TNFSF11 TNF IL6 IL1RN IL1B IL10
6
Show member pathways
13.4 TNFSF11 TNF IL6 IL1B IL10 CXCL8
7
Show member pathways
13.29 TNF TLR4 TLR2 PPP3CA IL1B IFNGR1
8
Show member pathways
13.19 TNF TLR4 TLR2 NLRP3 IL6 IL1B
9
Show member pathways
13.09 TNF TLR4 TLR2 PPP3CA IL6 IL1B
10
Show member pathways
12.95 TNF IL6 IL1B IL10 IFNG CXCL8
11
Show member pathways
12.93 TNF TLR4 TLR2 NLRP3 IL6 IL1B
12
Show member pathways
12.92 TNF TLR4 IL6 IL1B IFNG CXCL8
13 12.9 TNF TLR2 IL6 IL1B IFNGR1 IFNG
14
Show member pathways
12.82 TNF TLR4 TLR2 IL6 IL1B BMP2
15
Show member pathways
12.75 TNFSF11 TNF TLR4 TLR2 PPP3CA IL1B
16
Show member pathways
12.75 TNF TLR4 TLR2 PPP3CA IL6 IL1B
17
Show member pathways
12.74 TNF TLR4 TLR2 PPP3CA IL6 IL1B
18 12.73 TNFSF11 TNF TLR2 PPP3CA IL1RN IL1B
19
Show member pathways
12.71 TNF PPP3CA IL10 IFNGR1 IFNG
20
Show member pathways
12.68 TNF IL6 IL1B IL10 IFNG
21 12.55 TNF TLR4 NLRP3 IL1B CXCL8 CASP1
22
Show member pathways
12.54 TNFSF11 PPP3CA IL10 CTSK ACP5
23
Show member pathways
12.51 TNF TLR2 IL6 IL1B IFNG CXCL8
24
Show member pathways
12.5 TNF TLR4 IL6 IL1B IFNGR1 IFNG
25 12.48 TNF TLR4 NLRP3 IL6 IL1B CXCL8
26
Show member pathways
12.44 TNF IL6 IL1B IL10 IFNG CXCL8
27
Show member pathways
12.44 TNF TLR4 TLR2 IL1B IL10 IFNGR1
28
Show member pathways
12.42 IL6 IL10 IFNGR1 IFNG
29 12.41 TNF TLR4 NLRP3 IL6 IL1B CXCL8
30
Show member pathways
12.4 TNF IL6 IL10 CXCL8
31
Show member pathways
12.4 TNF TLR2 IL6 IL1RN IL1B CXCL8
32
Show member pathways
12.39 TNF IL6 IL1B IFNG
33
Show member pathways
12.39 TNF TLR4 TLR2 IL6 CXCL8
34
Show member pathways
12.38 TNF TLR4 NLRP3 IL1B IFNGR1 IFNG
35
Show member pathways
12.37 TNF PPP3CA NLRP3 IL6 IL1B IL10
36 12.36 TNF TLR4 TLR2 IL6 IFNGR1 IFNG
37 12.35 TNF IL6 IL1RN IL1B IL10 CXCL8
38
Show member pathways
12.33 TNF TLR4 TLR2 IL6 IL1B IFNGR1
39
Show member pathways
12.22 TNF TLR4 TLR2 IL6 IL1B IFNG
40 12.19 TNF TLR4 PPP3CA IL6 IL1B IFNG
41
Show member pathways
12.17 TNF TLR4 TLR2 IL6 IL1B IL10
42 12.17 TNF TLR4 TLR2 PPP3CA IL6 IL1B
43 12.16 TNF LPIN2 IL6 BMP2
44 12.16 TNF IL6 IL1B IL10 CXCL8
45 12.14 TNFSF11 TNF PPP3CA IL1B IFNGR1 IFNG
46 12.12 IL6 IL1B IFNG CXCL8 BMP2
47 12.1 TNF IL6 IL10 IFNG
48 12.1 TNFSF11 TNF TLR4 IL1B CXCL8
49 12.09 TNF TLR4 NLRP3 IL6 IL1B IL10
50 12.07 TLR4 IL6 IFNGR1 IFNG

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNFSF11 TNF NLRP3 IL6 IL1RN IL1B
2 extracellular space GO:0005615 9.32 TNFSF11 TNF IL6 IL1RN IL1B IL10
3 NLRP3 inflammasome complex GO:0072559 9.16 NLRP3 CASP1

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.37 TLR4 TLR2 NLRP3 IL6 IL1RN IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.17 TNFSF11 TNF TLR4 TLR2 PPP3CA NLRP3
3 negative regulation of cell proliferation GO:0008285 10.15 TLR2 IL6 IL1B IL10 CXCL8 BMP2
4 positive regulation of protein phosphorylation GO:0001934 10.03 TNF IL1B IFNG BMP2
5 response to lipopolysaccharide GO:0032496 10.03 TLR4 TLR2 IL1B IL10 ACP5
6 immune response GO:0006955 10.02 TNFSF11 TNF TLR4 TLR2 IL6 IL1RN
7 activation of MAPK activity GO:0000187 10 TNF TLR4 IL1B BMP2
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10 TNFSF11 TNF TLR4 IL1RN IL1B CASP1
9 defense response to Gram-positive bacterium GO:0050830 9.98 TNF TLR2 NLRP3 IL6 ACP5
10 positive regulation of inflammatory response GO:0050729 9.97 TNF TLR4 TLR2 IL1B
11 regulation of inflammatory response GO:0050727 9.96 TNF TLR4 NLRP3 CASP1
12 positive regulation of gene expression GO:0010628 9.96 TNFSF11 TNF TLR4 TLR2 PPP3CA IL6
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNFSF11 TNF TLR4 TLR2 NLRP3 IL6
14 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL1RN IL10
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.93 TNF TLR4 TLR2 IL1B
16 positive regulation of JNK cascade GO:0046330 9.93 TNFSF11 TNF TLR4 IL1RN IL1B
17 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 TNFSF11 TNF PPP3CA IL6 IL1B IL10
18 cellular response to mechanical stimulus GO:0071260 9.92 TLR4 IL1B CASP1
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 IFNG
20 cellular response to organic cyclic compound GO:0071407 9.92 TNF IL1B BMP2
21 regulation of insulin secretion GO:0050796 9.92 TNF IL1B IFNG
22 apoptotic signaling pathway GO:0097190 9.92 TNF TLR4 CASP1
23 negative regulation of tumor necrosis factor production GO:0032720 9.91 TLR4 IL10 ACP5
24 humoral immune response GO:0006959 9.91 TNF IL6 IFNG
25 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.9 TNF NLRP3 CASP1
26 positive regulation of phagocytosis GO:0050766 9.9 TNF IL1B IFNG
27 positive regulation of epithelial to mesenchymal transition GO:0010718 9.89 IL6 IL1B BMP2
28 positive regulation of interferon-gamma production GO:0032729 9.89 TNF TLR4 IL1B
29 toll-like receptor signaling pathway GO:0002224 9.89 TLR4 TLR2 CTSK
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.89 TNF TLR4 IL1B IFNG
31 negative regulation of interleukin-6 production GO:0032715 9.88 TNF TLR4 IL10
32 positive regulation of interleukin-1 beta secretion GO:0050718 9.88 TLR4 NLRP3 CASP1
33 positive regulation of interleukin-6 secretion GO:2000778 9.88 TNF TLR4 TLR2 IL1B
34 positive regulation of JAK-STAT cascade GO:0046427 9.87 TNF IL6 IL10
35 negative regulation of neurogenesis GO:0050768 9.87 TNF IL6 IL1B
36 positive regulation of interleukin-12 production GO:0032735 9.87 TLR4 TLR2 IFNG
37 lipopolysaccharide-mediated signaling pathway GO:0031663 9.87 TNF TLR4 TLR2 IL1B
38 microglial cell activation GO:0001774 9.86 TNF TLR2 IFNGR1 IFNG
39 bone resorption GO:0045453 9.85 TNFSF11 CTSK ACP5
40 positive regulation of osteoclast differentiation GO:0045672 9.85 TNFSF11 TNF IFNG
41 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR4 TLR2 IL1B
42 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR4 TLR2 IL6 IL1RN IL1B
43 positive regulation of glial cell proliferation GO:0060252 9.83 TNF IL6 IL1B
44 positive regulation of amyloid-beta formation GO:1902004 9.83 TNF IFNGR1 IFNG
45 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.83 TNF IL1B IFNG
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.82 TNF IL1B IL10
47 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.82 TLR4 TLR2 IFNG
48 cytokine-mediated signaling pathway GO:0019221 9.81 TNFSF11 TNF IL6 IL1RN IL1B IL10
49 positive regulation of neuroinflammatory response GO:0150078 9.8 TNF IL6 IL1B
50 positive regulation of chemokine production GO:0032722 9.8 TNF TLR4 TLR2 IL6

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 TNFSF11 TNF TLR4 TLR2 SPTLC1 PPP3CA
2 cytokine activity GO:0005125 9.28 TNFSF11 TNF IL6 IL1RN IL1B IL10
3 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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