Osteonecrosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OST003 MIFTS: 66	Osteonecrosis Categories: Blood diseases, Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Osteonecrosis

MalaCards integrated aliases for Osteonecrosis:

Name: Osteonecrosis ³⁸ ¹² ⁷⁶ ⁴³ ⁴⁴ ¹⁵

Aseptic Necrosis ¹² ²⁹

Bone Necrosis ¹² ⁷³

Avascular Necrosis of Bone ¹²

Classifications:

MalaCards categories:
Anatomical: Bone diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Other osteopathies

Osteonecrosis

Osteonecrosis due to drugs

Osteonecrosis due to previous trauma

Osteonecrosis, unspecified

Osteopathies in diseases classified elsewhere

Osteonecrosis due to haemoglobinopathy

Osteonecrosis in other diseases classified elsewhere

External Ids:

Disease Ontology ¹² DOID:10159

ICD10 ³³ M87 M87.9 M87.1 more

ICD9CM ³⁵ 732.3 733.41 733.42 more

MeSH ⁴⁴ D010020

NCIt ⁵⁰ C34404 C34841 C34880 more

SNOMED-CT ⁶⁸ 17926002 29281007 34686004 more

UMLS ⁷³ C0003977 C0027543 C0029445 more

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Summaries for Osteonecrosis

MedlinePlus : ⁴³ Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down. You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well. No one is sure what causes the disease. Risk factors include Long-term steroid treatment Alcohol abuse Joint injuries Having certain diseases, including arthritis and cancer Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteonecrosis, also known as aseptic necrosis, is related to osteonecrosis of the jaw and legg-calve-perthes disease, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Osteonecrosis is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Rheumatoid arthritis. The drugs Alendronate and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : ¹² An ischemic bone disease that results in necrosis located in bone.

Wikipedia : ⁷⁶ Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

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Related Diseases for Osteonecrosis

Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)

#	Related Disease	Score	Top Affiliating Genes
1	osteonecrosis of the jaw	33.7	CYP2C8 FDPS VEGFA
2	legg-calve-perthes disease	32.4	COL2A1 SERPINC1 SERPINE1
3	myeloma, multiple	30.8	ABCB1 TNFRSF11B TNFSF11 VEGFA
4	thrombophilia	30.6	F2 MTHFR SERPINC1 SERPINE1
5	osteomyelitis	30.5	ACP5 BMP2 TNFSF11
6	disseminated intravascular coagulation	30.1	F2 SERPINC1 SERPINE1
7	protein s deficiency	30.0	F2 MTHFR SERPINC1
8	kummell's disease	29.9	TNFRSF11B TNFSF11
9	villonodular synovitis	29.9	ACP5 TNFSF11
10	periodontitis	29.9	BGLAP RUNX2 TNFRSF11B TNFSF11
11	renal osteodystrophy	29.9	BGLAP PTH TNFRSF11B
12	osteoporotic fracture	29.8	MTHFR TNFRSF11B
13	antithrombin iii deficiency	29.7	F2 MTHFR SERPINC1
14	protein c deficiency	29.7	F2 MTHFR SERPINC1
15	antiphospholipid syndrome	29.7	F2 MTHFR SERPINC1
16	endosteal hyperostosis, autosomal dominant	29.6	BMP2 TNFRSF11B TNFSF11
17	thrombosis	29.6	F2 MTHFR SERPINC1 SERPINE1
18	giant cell tumor	29.6	BGLAP TNFRSF11B TNFSF11
19	pseudoarthrosis	29.4	BMP2 BMP7 PTH
20	hyperparathyroidism	29.4	ACP5 BGLAP PTH TNFRSF11B
21	vascular disease	29.3	F2 MTHFR SERPINC1 SERPINE1 TNFRSF11B VEGFA
22	bone resorption disease	29.2	ACP5 BGLAP BMP2 PTH RUNX2 TNFRSF11B
23	osteoporosis	29.1	ACP5 BGLAP BMP2 COL2A1 CYP3A4 FDPS
24	paget's disease of bone	29.0	ACP5 BGLAP PTH TNFRSF11B TNFSF11
25	glucocorticoid-induced osteoporosis	28.9	ACP5 BGLAP BMP2 PTH RUNX2 TNFRSF11B
26	bone disease	28.8	ACP5 BGLAP BMP7 COL2A1 PTH RUNX2
27	dysbaric osteonecrosis	12.5
28	avascular necrosis of femoral head, primary, 1	11.7
29	familial avascular necrosis of the femoral head	11.6
30	kohler's disease	11.4
31	freiberg's disease	11.3
32	kienbock's disease	11.3
33	osgood-schlatter's disease	11.2
34	panner disease	11.2
35	sinding-larsen-johansson disease	11.2
36	thiemann disease	11.0
37	gaucher disease, type iii	11.0
38	systemic lupus erythematosus	10.4
39	lymphocytic leukemia	10.4
40	lupus erythematosus	10.4
41	leukemia	10.4
42	leukemia, acute lymphoblastic	10.4
43	arthritis	10.3
44	inferior vena cava interruption	10.3	MTHFR SERPINE1
45	breast cancer	10.3
46	prostate cancer	10.3
47	neonatal stroke	10.3	MTHFR SERPINE1
48	amaurosis fugax	10.3	MTHFR SERPINE1
49	hemifacial spasm	10.3	MTHFR VEGFA
50	mesenteric vascular occlusion	10.3	F2 MTHFR

Graphical network of the top 20 diseases related to Osteonecrosis:

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Symptoms & Phenotypes for Osteonecrosis

UMLS symptoms related to Osteonecrosis:

back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Osteonecrosis:

⁴⁶ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.26	ABCB1 BMP2 BMP7 COL2A1 F2 PTH
2	growth/size/body region	MP:0005378	10.26	ABCB1 BMP2 BMP7 COL2A1 F2 MTHFR
3	hematopoietic system	MP:0005397	10.2	ABCB1 BMP2 BMP7 F2 PTH RUNX2
4	immune system	MP:0005387	10.18	ABCB1 BMP2 BMP7 COL2A1 F2 PTH
5	homeostasis/metabolism	MP:0005376	10.17	ABCB1 BMP2 COL2A1 F2 MTHFR PTH
6	craniofacial	MP:0005382	10.11	BMP2 BMP7 COL2A1 PTH RUNX2 TNFRSF11B
7	mortality/aging	MP:0010768	10.07	ABCB1 BMP2 BMP7 COL2A1 F2 MTHFR
8	digestive/alimentary	MP:0005381	10.04	ABCB1 BMP2 BMP7 COL2A1 F2 RUNX2
9	limbs/digits/tail	MP:0005371	10.02	BMP2 BMP7 COL2A1 MTHFR PTH RUNX2
10	liver/biliary system	MP:0005370	9.87	ABCB1 COL2A1 MTHFR RUNX2 SERPINC1 SERPINE1
11	reproductive system	MP:0005389	9.81	ABCB1 BMP2 BMP7 F2 MTHFR RUNX2
12	respiratory system	MP:0005388	9.5	BMP7 COL2A1 F2 RUNX2 SERPINE1 TNFSF11
13	skeleton	MP:0005390	9.32	BMP2 BMP7 COL2A1 F2 MTHFR PTH

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Drugs & Therapeutics for Osteonecrosis

Drugs for Osteonecrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Alendronate

Approved

Phase 4,Phase 2,Phase 1

66376-36-1, 121268-17-5

2088

Zoledronic acid

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

118072-93-8

68740

Pentoxifylline

Approved, Investigational

Phase 4,Phase 3

6493-05-6

4740

Tocopherol

Approved, Investigational

Phase 4,Phase 3

1406-66-2

14986

Heparin

Approved, Investigational

Phase 4

9005-49-6

772 46507594

Enoxaparin

Approved

Phase 4

9005-49-6

772

Rivaroxaban

Approved

Phase 4

366789-02-8

Dalteparin

Approved

Phase 4

9005-49-6

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Vitamin E

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 3

59-02-9

14985

Serine

Approved, Nutraceutical

Phase 4

56-45-1

5951

Tocotrienol

Investigational

Phase 4,Phase 3

6829-55-6

Bone Density Conservation Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Diphosphonates

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Anesthetics

Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Vitamins

Phase 4,Phase 3,Phase 2,Phase 1

Phosphodiesterase Inhibitors

Phase 4,Phase 3

Vasodilator Agents

Phase 4,Phase 3

Free Radical Scavengers

Phase 4,Phase 3

Tocotrienols

Phase 4,Phase 3

Trace Elements

Phase 4,Phase 3,Phase 2

Micronutrients

Phase 4,Phase 3,Phase 2

Radiation-Protective Agents

Phase 4,Phase 3

Tocopherols

Phase 4,Phase 3

Platelet Aggregation Inhibitors

Phase 4,Phase 3

Antioxidants

Phase 4,Phase 3

Protective Agents

Phase 4,Phase 3

protease inhibitors

Phase 4

calcium heparin

Phase 4

Factor Xa Inhibitors

Phase 4

Heparin, Low-Molecular-Weight

Phase 4

Anticoagulants

Phase 4

Antithrombins

Phase 4

Antithrombin III

Phase 4

HIV Protease Inhibitors

Phase 4

Serine Proteinase Inhibitors

Phase 4

Pharmaceutical Solutions

Phase 4,Phase 2,Not Applicable

Hematinics

Phase 4,Not Applicable

Ferrosoferric Oxide

Phase 4,Not Applicable

Parenteral Nutrition Solutions

Phase 4,Not Applicable

Adjuvants, Immunologic

Phase 4

Viscosupplements

Phase 4

Thiotepa

Approved, Investigational

Phase 3

52-24-4

5453

Fludarabine

Approved

Phase 3

75607-67-9, 21679-14-1

30751

Etoposide

Approved

Phase 3

33419-42-0

36462

Denosumab

Approved

Phase 3,Phase 1,Phase 2

615258-40-7

Docetaxel

Approved, Investigational

Phase 3,Phase 2

114977-28-5

148124

Gemcitabine

Approved

Phase 3

95058-81-4

60750

Interventional clinical trials:

(show top 50) (show all 201)

#	Name	Status	NCT ID	Phase	Drugs
1	Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis	Unknown status	NCT00265252	Phase 4	Alendronate
2	Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases	Completed	NCT00434447	Phase 4	Zoledronic acid
3	Comparison of Ceramic-on-Ceramic and Ceramic-on-Highly-Cross-Linked Polyethylene Bearings	Completed	NCT01806766	Phase 4
4	A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients	Completed	NCT01345097	Phase 4
5	Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years Old	Completed	NCT02338596	Phase 4
6	Effectiveness of DiscontinuinG bisphosphonatEs Study: R21 Pilot Study	Completed	NCT02139007	Phase 4	Alendronate
7	Management of Mandibular ORN: PENTO as Medical Treatment	Completed	NCT02368457	Phase 4	Pentoxifylline and Tocopherol
8	Ceramic-on-Ceramic Versus Ceramic-on-HXLPE THA	Completed	NCT03639532	Phase 4
9	Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty	Completed	NCT02379663	Phase 4	Rivaroxaban;Enoxaparin
10	Benefit of Orthopedic Navigation in the ARThroplasty of the Hip	Completed	NCT01496300	Phase 4
11	Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI	Recruiting	NCT02893293	Phase 4	Ferumoxytol-enhanced magnetic resonance imaging
12	Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis	Recruiting	NCT02984228	Phase 4	Hyaluronic Acid
13	Prolonged Protection From Bone Disease in Multiple Myeloma	Recruiting	NCT02286830	Phase 4	Zoledronic acid
14	Optetrak Posterior Stabilized Versus Optetrak Hi-Flex	Withdrawn	NCT00808613	Phase 4
15	Implantation of Bone Marrow Cells to Treat Avascular Necrosis of Femoral Head (ANFH)	Unknown status	NCT01613612	Phase 2, Phase 3
16	Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia	Unknown status	NCT01423747	Phase 3	VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
17	ALL-SCT BFM International- HSCT in Children and Adolescents With ALL	Unknown status	NCT01423500	Phase 3	VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
18	Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral Head	Completed	NCT00505219	Phase 3
19	Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial	Completed	NCT00532220	Phase 3	Ibandronate IV;Placebo
20	Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head	Completed	NCT00939900	Phase 3	zoledronic acid (aclasta)
21	Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis	Completed	NCT00523341	Phase 3
22	Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement	Completed	NCT00869206	Phase 3	zoledronic acid
23	Simultaneous Study of Gemcitabine-Docetaxel Combination Adjuvant Treatment, as Well as Extended Bisphosphonate and Surveillance-Trial	Completed	NCT02181101	Phase 3	FEC-DocGemzar adjuvant chemotherapy;FEC-Doc adjuvant chemotherapy;Zoledronic acid i.v. 2 years;Zoledronic acid i.v. 5 years
24	Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone	Completed	NCT01924286	Phase 3	Prednisone;Placebo
25	Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee.	Completed	NCT02709486	Phase 3	Tanezumab;Tanezumab;Placebo
26	N-Acetylcysteine in Patients With Sickle Cell Disease	Completed	NCT01849016	Phase 3	N-Acetylcysteine;Placebo
27	Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip	Recruiting	NCT03405974	Phase 3	Aspirin;Placebo
28	Study on Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral Head	Recruiting	NCT01529008	Phase 3	Core decompression/PREOB® implantation;Core decompression/placebo implantation
29	Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)	Recruiting	NCT03040778	Phase 3	Pentoxifylline;Placebo;Tocopherol
30	Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents	Recruiting	NCT02684708	Phase 3	cyclophosphamide, vincristine, prednisone, dacarbazine;cyclo, vcr, pred, dacarb,etop and doxo
31	Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks	Recruiting	NCT02051218	Phase 3	Denosumab (reduced dosing);Denosumab (standard dosing)
32	Efficacy and Safety of Systemic Treatments of Bone Metastases From Kidney Cancer in Patients Treated With Targeted Therapies	Recruiting	NCT03408652	Phase 3	denosumab
33	Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy.	Recruiting	NCT02609828	Phase 3	Tanezumab
34	Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head	Active, not recruiting	NCT01892514	Phase 3
35	ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee	Active, not recruiting	NCT01458782	Phase 2, Phase 3
36	Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2)	Active, not recruiting	NCT01908751	Phase 3	Vitamin D;Vitamin D Placebo
37	Study of Skeletal Response to Eliglustat in Patients With Gaucher Disease	Enrolling by invitation	NCT02536755	Phase 3	eliglustat GZ385660
38	Plasma Rich in Growth Factors for Treatment of Medication Related Osteonecrosis of the Jaw	Not yet recruiting	NCT03390777	Phase 2, Phase 3
39	Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis	Terminated	NCT02114489	Phase 3	ibandronate;Placebo
40	Comparison of Ibandronate - Zoledronate Regarding Nephrotoxicity in Multiple Myeloma	Terminated	NCT02739594	Phase 3	Ibandronate;Zoledronate
41	A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement	Terminated	NCT00208468	Phase 3
42	Osteonecrosis of the Hip and Bisphosphonate Treatment	Unknown status	NCT00781261	Phase 2	Zoledronic Acid;Placebo
43	MBCP Safety and Performance in the Osteonecrosis of Femur Head	Unknown status	NCT00289575	Phase 2
44	PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells	Completed	NCT01700920	Phase 2
45	Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral Head	Completed	NCT02890537	Phase 2	Core decompression/PREOB® implantation;Core decompression/BMC implantation
46	Effect of Cycle Ergometer in the Rehabilitation of Elderly Patients With Total Hip Arthroplasty	Completed	NCT01622465	Phase 2
47	Safety and Effectiveness of Alendronate for Bone Mineral Density in HIV-infected Children and Adolescents	Completed	NCT00921557	Phase 2	Alendronate;Placebo
48	Shock Wave Therapy for Osteoporosis	Completed	NCT02630381	Phase 2
49	MK-5442 in the Treatment of Osteoporosis in Postmenopausal Women Previously Treated With an Oral Bisphosphonate (MK-5442-012)	Completed	NCT00996801	Phase 2	MK-5442;Placebo to MK-5442;Alendronate Sodium;Vitamin D3;Calcium carbonate;Placebo to Alendronate
50	Comparative Study of Neoadjuvant Chemotherapy With and Without Zometa for Management of Locally Advanced Breast Cancers	Completed	NCT01367288	Phase 2	Zometa + Neoadjuvant therapy;Neoadjuvant therapy

Search NIH Clinical Center for Osteonecrosis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Osteonecrosis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Osteonecrosis:

	JACC�, cultured cartilage for chondral lesion
	PREOB�, autologous osteoblasts for bone disorders

Embryonic/Adult Cultured Cells Related to Osteonecrosis:

Cultured cartilage (JACC�) PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677

Cochrane evidence based reviews: osteonecrosis

Sources

Genetic Tests for Osteonecrosis

Genetic tests related to Osteonecrosis:

#	Genetic test	Affiliating Genes
1	Aseptic Necrosis ²⁹

Sources

Anatomical Context for Osteonecrosis

MalaCards organs/tissues related to Osteonecrosis:

⁴¹

Bone, Bone Marrow, Testes, Breast, Endothelial, Prostate, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Osteonecrosis:

¹⁹

Bone

Sources

Publications for Osteonecrosis

Articles related to Osteonecrosis:

(show top 50) (show all 2582)

#	Title	Authors	Year
1	Severe bilateral knee osteonecrosis in a young man with human immunodeficiency virus. ( 30425776 )	McCurdie DFK...Sandhu DGS	2019
2	MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis. ( 30551361 )	Dai Z...Sun Z	2019
3	Osteonecrosis in children with acute lymphoblastic leukemia: A report from Children's Cancer Hospital Egypt (CCHE). ( 30183135 )	Ali N...Sidhom I	2019
4	Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective. ( 29955628 )	George E.L....Saunders M.M.	2018
5	Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )	Sakamoto K....Horibe K.	2018
6	Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management. ( 29799056 )	Toh C.L....Dutton A.	2018
7	Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review. ( 29977926 )	Sacco R....Blythe J.S.J.	2018
8	Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteenA year follow-up. ( 29594456 )	Wang W....Gao F.	2018
9	Chronic myelogenous leukemia presenting with osteonecrosis of the jaw as a rare but debilitating toxicity of dasatinib: a case report and literature review. ( 29941400 )	Won A.M....Chambers M.	2018
10	Association of common comorbidities with osteonecrosis: a nationwide population-based case-control study in Denmark. ( 29439082 )	Dima A....Thomsen R.W.	2018
11	Osteonecrosis of the Jaw and Rebound Hypercalcemia in Young People Treated With Denosumab for Giant Cell Tumor of Bone. ( 29211870 )	Uday S....HAPgler W.	2018
12	Short stem survival after osteonecrosis of the femoral head. ( 29396635 )	Schnurr C....Eysel P.	2018
13	Enhanced bone defect repairing effects in glucocorticoid-induced osteonecrosis of the femoral head using a porous nano-lithium-hydroxyapatite/gelatin microsphere/erythropoietin composite scaffold. ( 29369309 )	Li D....Kang P.	2018
14	Development of antiresorptive agent-related osteonecrosis of the jaw after dental implant removal: a case report. ( 29870295 )	Yamamoto S....Takenobu T.	2018
15	Efficacy of bisphosphonates in the treatment of femoral head osteonecrosis: A PRISMA-compliant meta-analysis of animal studies and clinical trials. ( 29362430 )	Li D....Kang P.	2018
16	Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice. ( 29729428 )	Kuroshima S....Sawase T.	2018
17	Early removal of sequestrum in patients affected by medication-related osteonecrosis of the jaw. ( 29422306 )	Kharazmi M....Hallberg P.	2018
18	Machine learning to predict the occurrence of bisphosphonate-related osteonecrosis of the jaw associated with dental extraction: A preliminary report. ( 29698784 )	Kim D.W....Cha I.H.	2018
19	The biological basis for concentrated iliac crest aspirate to enhance core decompression in the treatment of osteonecrosis. ( 29435623 )	Goodman S.B.	2018
20	Th17 and IL-17 exhibit higher levels in osteonecrosis of the femoral head and have a positive correlation with severity of pain. ( 29952419 )	Zou D....Li J.	2018
21	Correction to : Hip osteonecrosis: stem cells for life or behead and arthroplasty? ( 29934718 )	Hernigou P....Hernigou J.	2018
22	Diving, Dysbaric Osteonecrosis ( 29493935 )	White T.C....Cooper J.S.	2018
23	Conservative surgical treatment of medication related osteonecrosis of the jaw (MRONJ) lesions in patients affected by osteoporosis exposed to oral bisphosphonates: 24 months follow-up. ( 29802059 )	Nisi M....Gabriele M.	2018
24	Microbial population changes in patients with medication-related osteonecrosis of the jaw treated with systemic antibiotics. ( 29325851 )	De Bruyn L....Politis C.	2018
25	Recommendations for the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Systematic Review. ( 29747794 )	Aparecida Cariolatto F....Bonilauri Ferreira A.P.	2018
26	Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-NaA^ve Patient: A Comprehensive Review of the Literature. ( 29850569 )	Pimolbutr K....Fedele S.	2018
27	Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )	Martini G....Di Palma A.	2018
28	Osteonecrosis of the Jaw in a Patient With Bone Metastatic Prostate Cancer After Long-term Bisphosphonate Treatment With Severe Deterioration Following Radium-223. ( 29861164 )	Herlofson B.B....Bruland A.9.S.	2018
29	Thrombophilia-Associated Factors in Patients with Spontaneous Osteonecrosis of the Knee. ( 29308659 )	Marom N....Hetsroni I.	2018
30	Osteonecrosis of the jaws: a 14-year retrospective survey of hospital admissions. ( 29432652 )	McGowan K....Acton C.	2018
31	Accuracy of MRI diagnosis of early osteonecrosis of the femoral head: a meta-analysis and systematic review. ( 29973239 )	Zhang Y.Z....Zheng W.	2018
32	Comment on &quot;Nasolabial Flap Improves Healing in Medication-Related Osteonecrosis of the Jaw&quot; by Lemound etA al. ( 29902417 )	Myoken Y....Fujita Y.	2018
33	The association with xerostomia from sialadenitis and the jaw osteonecrosis in head and neck cancer population: a nationwide cohort study. ( 29725850 )	Huang Y.F....Chang C.T.	2018
34	Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis. ( 29289789 )	Messer J.G....Aguirre J.I.	2018
35	FGF2 and FAM201A affect the development of osteonecrosis of the femoral head after femoral neck fracture. ( 29382571 )	Huang G....Shi J.	2018
36	Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. ( 29408511 )	Elsayed R....Elsalanty M.E.	2018
37	Comparing osteonecrosis clinical phenotype, timing, and risk factors in children and young adults treated for acute lymphoblastic leukemia. ( 29943905 )		2018
38	Medication-related osteonecrosis of the jaw incidence in patients exposed concomitantly to bone resorption inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors: is it generalizable to all solid tumors? ( 29860712 )		2018
39	Antiresorptive drug-related osteonecrosis of the jaws, literature review and 5A years of experience. ( 29948937 )		2018
40	A new 3D printed titanium metal trabecular bone reconstruction system for early osteonecrosis of the femoral head. ( 29952948 )		2018
41	Vitamin D supplementation: Hypothetical effect on medication-related osteonecrosis of the jaw. ( 29857915 )		2018
42	The role of the subchondral layer in osteonecrosis of the femoral head: analysis based on HR-QCT in comparison to MRI findings. ( 29979104 )		2018
43	Osteonecrosis of the jaw in patients transitioning from bisphosphonates to denosumab treatment for osteoporosis. ( 29713913 )		2018
44	High-energy extracorporeal shock wave therapy for nontraumatic osteonecrosis of the femoral head. ( 29394948 )		2018
45	Auto-Fluorescence and Histopathologic Evaluation of Medication-Related Osteonecrosis of the Jaws: Perspectives for Treatment. ( 29944562 )		2018
46	Authors' reply: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management. ( 29796683 )		2018
47	Extravascular Hydrophobic Surfaces, Fat Droplets, and the Connection With Decompression Illness: Spinal, Joint Pain, and Dysbaric Osteonecrosis. ( 29636703 )		2018
48	Medication-related osteonecrosis of the jaw, osteoradionecrosis, and osteomyelitis: A comparative histopathological study. ( 29723337 )		2018
49	The influence of alendronate and tooth extraction on the incidence of osteonecrosis of the jaw among osteoporotic subjects. ( 29694412 )		2018
50	Duration of treatment with bisphosphonates at the time of osteonecrosis of the jaw onset in patients with rheumatoid arthritis. Review. ( 29325766 )		2018

Sources

Genes for Osteonecrosis

Genes related to Osteonecrosis (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BMP2	Bone Morphogenetic Protein 2	Protein Coding	24.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	23.84	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TNFSF11	TNF Superfamily Member 11	Protein Coding	23.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	23.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	23.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	22.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	RUNX2	Runt Related Transcription Factor 2	Protein Coding	22.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	SERPINE1	Serpin Family E Member 1	Protein Coding	22.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	F2	Coagulation Factor II, Thrombin	Protein Coding	22.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	22.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	22.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	22.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	22.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	PTH	Parathyroid Hormone	Protein Coding	21.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	21.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	SERPINC1	Serpin Family C Member 1	Protein Coding	21.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	21.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	BMP7	Bone Morphogenetic Protein 7	Protein Coding	21.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Osteonecrosis

Sources

Expression for Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Sources

Pathways for Osteonecrosis

Pathways related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	Parathyroid hormone synthesis, secretion and action ³⁷	11.78	BGLAP PTH RUNX2 TNFSF11
2	Rheumatoid arthritis ³⁷	11.71	ACP5 TNFSF11 VEGFA
3	Statin Pathway - Generalized, Pharmacokinetics ⁶¹ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶¹ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶¹ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶¹ Fluvastatin Pathway, Pharmacokinetics ⁶¹ Ibuprofen Pathway, Pharmacokinetics ⁶¹ Pravastatin Pathway, Pharmacokinetics ⁶¹ Rosiglitazone Pathway, Pharmacokinetics ⁶¹ Rosuvastatin Pathway, Pharmacokinetics ⁶¹	11.68	ABCB1 CYP2C8 CYP3A4
4	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Show member pathways Clozapine Pathway, Pharmacokinetics ⁶¹ Doxepin Pathway, Pharmacokinetics ⁶¹ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Gefitinib Pathway, Pharmacokinetics ⁶¹ Nevirapine Pathway, Pharmacokinetics ⁶¹ Pazopanib Pathway, Pharmacokinetics ⁶¹ Warfarin Pathway, Pharmacokinetics ⁶¹	11.61	ABCB1 CYP2C8 CYP3A4
5	Clomipramine Pathway, Pharmacokinetics ⁶¹ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶¹ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁶ Citalopram Pathway, Pharmacokinetics ⁶¹ Clopidogrel Pathway, Pharmacokinetics ⁶¹ Colchicine Metabolic Pathway ¹ Imipramine/Desipramine Pathway, Pharmacokinetics ⁶¹ Lidocaine metabolism ¹ Olanzapine Pathway, Pharmacokinetics ⁶¹ Paroxetine Pathway, Pharmacokinetics ⁶¹ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶¹ Venlafaxine Pathway, Pharmacokinetics ⁶¹ Verapamil Pathway, Pharmacokinetics ⁶¹	11.57	ABCB1 CYP2C8 CYP3A4
6	Signaling by BMP ⁶⁶ Show member pathways BMP receptor signaling ¹ Bone Morphogenic Protein (BMP) Signalling and Regulation ¹	11.56	BMP2 BMP7 RUNX2
7	HIF-1-alpha transcription factor network ¹	11.5	ABCB1 SERPINE1 VEGFA
8	Phenytoin Pathway, Pharmacokinetics ⁶¹ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶¹ Carbamazepine Pathway, Pharmacokinetics ⁶¹ Cyclophosphamide Pathway, Pharmacokinetics ⁶¹ Efavirenz Pathway, Pharmacokinetics ⁶¹ Sorafenib Pharmacokinetics ⁶¹	11.48	ABCB1 CYP2C8 CYP3A4
9	Irinotecan Pathway ¹ Show member pathways Irinotecan Pathway, Pharmacodynamics ⁶¹ Irinotecan Pathway, Pharmacokinetics ⁶¹ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	11.39	ABCB1 CYP2C8 CYP3A4
10	Endochondral Ossification ¹	11.37	BMP7 COL2A1 PTH RUNX2 VEGFA
11	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.15	BGLAP PTH RUNX2 TNFSF11
12	Erlotinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Dasatinib Pathway, Pharmacokinetics ⁶¹	10.99	ABCB1 CYP2C8 CYP3A4
13	Drug Induction of Bile Acid Pathway ¹	10.83	ABCB1 CYP3A4
14	Osteoclast Signaling ¹	10.78	ACP5 TNFRSF11B TNFSF11
15	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.77	ABCB1 CYP3A4
16	Warfarin Pathway, Pharmacodynamics ⁶¹	10.76	BGLAP F2
17	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.75	BGLAP CYP3A4 PTH RUNX2 TNFRSF11B TNFSF11
18	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.72	ABCB1 CYP2C8 CYP3A4
19	Taxane Pathway, Pharmacokinetics ⁶¹	10.61	ABCB1 CYP2C8 CYP3A4
20	Vinka Alkaloid Pathway, Pharmacokinetics ⁶¹	10.56	ABCB1 CYP3A4
21	Osteoblast Signaling ¹	10.4	BGLAP PTH TNFRSF11B TNFSF11

Sources

GO Terms for Osteonecrosis

Cellular components related to Osteonecrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	BGLAP BMP2 BMP7 COL2A1 F2 PTH
2	endoplasmic reticulum lumen	GO:0005788	9.56	BGLAP COL2A1 F2 SERPINC1
3	collagen-containing extracellular matrix	GO:0062023	9.46	BMP7 COL2A1 SERPINC1 SERPINE1
4	extracellular space	GO:0005615	9.36	BGLAP BMP2 BMP7 COL2A1 F2 PTH

Biological processes related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 35)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.97	BMP2 BMP7 RUNX2 TNFSF11 VEGFA
2	animal organ morphogenesis	GO:0009887	9.84	BMP2 BMP7 TNFSF11
3	steroid metabolic process	GO:0008202	9.84	CYP2C8 CYP3A4 FDPS
4	osteoblast differentiation	GO:0001649	9.83	BGLAP BMP2 RUNX2
5	response to drug	GO:0042493	9.83	ABCB1 BGLAP MTHFR PTH TNFRSF11B
6	BMP signaling pathway	GO:0030509	9.8	BMP2 BMP7 RUNX2
7	cartilage development	GO:0051216	9.78	BMP2 BMP7 COL2A1
8	regulation of signaling receptor activity	GO:0010469	9.76	BMP2 BMP7 F2 PTH SERPINE1 TNFRSF11B
9	positive regulation of osteoblast differentiation	GO:0045669	9.75	BMP2 BMP7 RUNX2
10	odontogenesis of dentin-containing tooth	GO:0042475	9.73	BMP2 BMP7 RUNX2
11	bone development	GO:0060348	9.7	BGLAP COL2A1 TNFSF11
12	mammary gland alveolus development	GO:0060749	9.66	TNFSF11 VEGFA
13	regulation of osteoclast differentiation	GO:0045670	9.65	BGLAP TNFSF11
14	positive regulation of ossification	GO:0045778	9.65	BMP2 PTH
15	bone mineralization	GO:0030282	9.65	BGLAP BMP2 PTH
16	positive regulation of blood coagulation	GO:0030194	9.64	F2 SERPINE1
17	regulation of blood coagulation	GO:0030193	9.64	F2 SERPINC1
18	response to inorganic substance	GO:0010035	9.63	BGLAP TNFRSF11B
19	chondrocyte differentiation	GO:0002062	9.63	BMP2 COL2A1 RUNX2
20	embryonic skeletal joint morphogenesis	GO:0060272	9.62	BMP7 COL2A1
21	mesenchymal cell differentiation	GO:0048762	9.62	BMP2 BMP7
22	negative regulation of fibrinolysis	GO:0051918	9.61	F2 SERPINE1
23	oxidative demethylation	GO:0070989	9.6	CYP2C8 CYP3A4
24	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO:1901522	9.59	BMP2 RUNX2
25	proteoglycan metabolic process	GO:0006029	9.58	BMP2 COL2A1
26	positive regulation of bone mineralization	GO:0030501	9.58	BMP2 BMP7 PTH
27	cellular response to BMP stimulus	GO:0071773	9.56	BMP2 BMP7 COL2A1 RUNX2
28	lipid hydroxylation	GO:0002933	9.55	CYP2C8 CYP3A4
29	regulation of odontogenesis of dentin-containing tooth	GO:0042487	9.54	BMP2 RUNX2
30	bone resorption	GO:0045453	9.54	ACP5 PTH TNFSF11
31	response to vitamin D	GO:0033280	9.5	BGLAP BMP7 PTH
32	skeletal system development	GO:0001501	9.5	BGLAP BMP2 BMP7 COL2A1 PTH RUNX2
33	mesenchyme development	GO:0060485	9.49	BMP2 BMP7
34	ossification	GO:0001503	9.17	ACP5 BGLAP BMP2 BMP7 COL2A1 RUNX2
35	positive regulation of transcription by RNA polymerase II	GO:0045944	10.05	BMP2 BMP7 PTH RUNX2 SERPINE1 TNFSF11

Molecular functions related to Osteonecrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.56	BMP2 BMP7 F2 VEGFA
2	heparin binding	GO:0008201	9.46	BMP7 F2 SERPINC1 VEGFA
3	BMP receptor binding	GO:0070700	9.37	BMP2 BMP7
4	estrogen 16-alpha-hydroxylase activity	GO:0101020	9.32	CYP2C8 CYP3A4
5	cytokine activity	GO:0005125	9.02	BMP2 BMP7 TNFRSF11B TNFSF11 VEGFA
6	caffeine oxidase activity	GO:0034875	8.96	CYP2C8 CYP3A4

Sources

Sources for Osteonecrosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia