Categories: Blood diseases, Bone diseases, Rare diseases

Aliases & Classifications for Osteonecrosis

MalaCards integrated aliases for Osteonecrosis:

Name: Osteonecrosis 12 73 58 42 44 15 37 17 32
Bone Necrosis 12 58 70
Avascular Necrosis of Bone 12 29
Aseptic Necrosis 12


Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases

External Ids:

Disease Ontology 12 DOID:10159
MeSH 44 D010020
ICD10 via Orphanet 33 M87.0 M87.1 M87.2 more
UMLS via Orphanet 71 C0029445
Orphanet 58 ORPHA399158
UMLS 70 C0003977 C0027543 C0029445 more

Summaries for Osteonecrosis

MedlinePlus : 42 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down. You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well. No one is sure what causes the disease. Risk factors include Long-term steroid treatment Alcohol misuse Joint injuries Having certain diseases, including arthritis and cancer Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteonecrosis, also known as bone necrosis, is related to osteonecrosis of the jaw and myeloma, multiple, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Osteonecrosis is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Folate Metabolism and Wnt / Hedgehog / Notch. The drugs Chlorhexidine and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 An ischemic bone disease that results in necrosis located in bone.

Wikipedia : 73 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Osteonecrosis

Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 732)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis of the jaw 32.5 VEGFA NFATC1 FDPS CYP2C8
2 myeloma, multiple 31.1 VEGFA TNFSF11 TNF DKK1 ABCB1
3 osteomyelitis 31.0 TNFSF11 TNF NFATC1 BMP2 ACP5
4 osteoarthritis 30.9 TNFSF11 TNF COL2A1 BGLAP
5 exostosis 30.8 COL2A1 BMP2 BGLAP
6 gaucher's disease 30.8 MTHFR F2 COL2A1 BGLAP ACP5
7 antiphospholipid syndrome 30.7 TNF SERPINE1 MTHFR F2
8 osteomalacia 30.7 PTH CYP3A4 BGLAP
9 mammary paget's disease 30.6 TNFSF11 PTH FDPS BGLAP ACP5
10 mucositis 30.6 VEGFA MTHFR ABCB1
11 protein c deficiency 30.6 SERPINE1 MTHFR F2
12 thrombophilia due to thrombin defect 30.6 SERPINE1 MTHFR F2
13 disseminated intravascular coagulation 30.6 TNF SERPINE1 F2
14 thrombophilia due to activated protein c resistance 30.5 SERPINE1 MTHFR F2
15 pulmonary embolism 30.5 SERPINE1 MTHFR F2
16 synovitis 30.5 VEGFA TNFSF11 TNF COL2A1 ACP5
17 periodontitis 30.5 TNFSF11 TNF RUNX2 BGLAP ACP5
18 beta-thalassemia 30.4 TNFSF11 MTHFR F2 BGLAP
19 thrombophlebitis 30.3 SERPINE1 MTHFR F2
20 tendinitis 30.3 VEGFA TNF ACP5
21 vascular disease 30.3 VEGFA TNF SERPINE1 PTH MTHFR F2
22 arthritis 30.2 VEGFA TNFSF11 TNF PTH COL2A1 ACP5
23 bone inflammation disease 30.2 VEGFA TNFSF11 TNF COL2A1 ACP5
24 leukostasis 30.2 VEGFA TNF NFATC1
25 homocysteinemia 30.2 SERPINE1 MTHFR F2
26 cellulitis 30.2 TNFSF11 TNF F2
27 exanthem 30.2 VEGFA TNF F2 CYP3A4
28 renal osteodystrophy 30.1 TNFSF11 PTH BGLAP ACP5
29 sudden sensorineural hearing loss 30.1 MTHFR F2
30 hyperparathyroidism 30.1 TNFSF11 PTH BGLAP ACP5
31 kummell's disease 30.1 TNFSF11 DKK1
32 spondylitis 30.1 TNFSF11 TNF DKK1
33 paget's disease of bone 30.0 TNFSF11 TNF PTH DKK1 BGLAP ACP5
34 rheumatoid arthritis 30.0 VEGFA TNFSF11 TNF PTH MTHFR COL2A1
35 catastrophic antiphospholipid syndrome 30.0 SERPINE1 MTHFR
36 migraine with or without aura 1 30.0 TNF MTHFR F2 CYP3A4
37 hellp syndrome 30.0 VEGFA SERPINE1 MTHFR F2
38 peripheral vascular disease 30.0 VEGFA SERPINE1 MTHFR F2
39 hepatitis a 30.0 TNF F2 CYP3A4
40 spondylolisthesis 30.0 PTH BMP7 BMP2
41 eclampsia 29.9 VEGFA TNF MTHFR F2
42 placenta disease 29.9 VEGFA TNF MTHFR F2
43 cerebrovascular disease 29.9 TNF SERPINE1 MTHFR F2
44 spondyloarthropathy 1 29.9 TNFSF11 TNF PTH BGLAP
45 secondary hyperparathyroidism 29.8 PTH BMP7 BGLAP ACP5
46 poems syndrome 29.8 VEGFA TNFSF11 TNF
47 gorham's disease 29.8 VEGFA TNFSF11 PTH
48 gingival recession 29.8 TNFSF11 TNF BMP2
49 metaphyseal dysplasia 29.8 RUNX2 COL2A1 ACP5
50 spondylolysis 29.8 BMP7 BMP2

Graphical network of the top 20 diseases related to Osteonecrosis:

Diseases related to Osteonecrosis

Symptoms & Phenotypes for Osteonecrosis

UMLS symptoms related to Osteonecrosis:

back pain; sciatica; muscle cramp

MGI Mouse Phenotypes related to Osteonecrosis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.39 ABCB1 BMP2 BMP7 COL2A1 DKK1 F2
2 homeostasis/metabolism MP:0005376 10.38 ABCB1 BGLAP BMP2 BMP7 COL2A1 DKK1
3 cardiovascular system MP:0005385 10.35 ABCB1 BMP2 BMP7 COL2A1 F2 LRP5
4 craniofacial MP:0005382 10.3 BMP2 BMP7 COL2A1 DKK1 LRP5 NFATC1
5 immune system MP:0005387 10.3 ABCB1 BGLAP BMP2 BMP7 COL2A1 F2
6 hematopoietic system MP:0005397 10.27 ABCB1 BGLAP BMP2 BMP7 LRP5 NFATC1
7 endocrine/exocrine gland MP:0005379 10.22 ABCB1 BGLAP BMP7 F2 LRP5 PTH
8 digestive/alimentary MP:0005381 10.2 ABCB1 BMP2 BMP7 COL2A1 F2 NFATC1
9 mortality/aging MP:0010768 10.2 ABCB1 BMP2 BMP7 COL2A1 DKK1 F2
10 embryo MP:0005380 10.19 BMP2 BMP7 COL2A1 DKK1 F2 LRP5
11 limbs/digits/tail MP:0005371 10.18 BMP2 BMP7 COL2A1 DKK1 LRP5 MTHFR
12 integument MP:0010771 10.09 BMP7 F2 MTHFR NFATC1 RUNX2 SERPINE1
13 liver/biliary system MP:0005370 10.02 ABCB1 COL2A1 LRP5 MTHFR NFATC1 RUNX2
14 reproductive system MP:0005389 9.96 ABCB1 BGLAP BMP2 BMP7 F2 MTHFR
15 respiratory system MP:0005388 9.85 BMP7 COL2A1 DKK1 F2 NFATC1 RUNX2
16 skeleton MP:0005390 9.83 BGLAP BMP2 BMP7 COL2A1 DKK1 F2
17 vision/eye MP:0005391 9.32 BMP7 COL2A1 DKK1 LRP5 MTHFR PTH

Drugs & Therapeutics for Osteonecrosis

Drugs for Osteonecrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
6 Ferrosoferric Oxide Phase 4
7 Hematinics Phase 4
8 Parenteral Nutrition Solutions Phase 4
9 Chlorhexidine gluconate Phase 4
10 Antibiotics, Antitubercular Phase 4
11 Anti-Infective Agents, Local Phase 4
12 Anti-Bacterial Agents Phase 4
13 Clindamycin palmitate Phase 4
14 Clavulanic Acids Phase 4
15 penicillins Phase 4
16 Clindamycin phosphate Phase 4
17 Amoxicillin-Potassium Clavulanate Combination Phase 4
18 Anti-Infective Agents Phase 4
19 Disinfectants Phase 4
20 Dermatologic Agents Phase 4
21 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
24 Anti-Inflammatory Agents Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Analgesics Phase 3
27 Cyclooxygenase Inhibitors Phase 3
28 Fibrinolytic Agents Phase 3
29 Antirheumatic Agents Phase 3
30 Anti-Inflammatory Agents, Non-Steroidal Phase 3
31 Antipyretics Phase 3
32 Vasodilator Agents Phase 3
33 Radiation-Protective Agents Phase 3
34 Phosphodiesterase Inhibitors Phase 3
35 Platelet Aggregation Inhibitors Phase 3
36 Mitogens Phase 2, Phase 3
37 Ibandronic Acid Phase 3
Atorvastatin Approved Phase 2 134523-00-5 60823
39 Calcium, Dietary Phase 2
40 Pharmaceutical Solutions Phase 2
41 Polymethyl Methacrylate Phase 1, Phase 2
42 Antihypertensive Agents Phase 2
43 Anticholesteremic Agents Phase 2
44 Antimetabolites Phase 2
45 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
46 Lipid Regulating Agents Phase 2
47 Hypolipidemic Agents Phase 2
Calcium Nutraceutical Phase 2 7440-70-2 271
Alendronate Approved Phase 1 121268-17-5, 66376-36-1 2088
Coal tar Approved Phase 1 8007-45-2

Interventional clinical trials:

(show top 50) (show all 117)
# Name Status NCT ID Phase Drugs
1 Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis Unknown status NCT00265252 Phase 4 Alendronate
2 Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment Completed NCT02368457 Phase 4 Pentoxifylline and Tocopherol
3 Comparison of Ceramic-on-Ceramic and Ceramic-on-Highly-Cross-Linked Polyethylene Bearings in Primary Cementless Total Hip Arthroplasty in the Same Patients Completed NCT01806766 Phase 4
4 A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients Completed NCT01345097 Phase 4
5 Comparison of the Outcomes of Ultra-Short Anatomic and Conventional Cementless Stems in Patients Younger Than Fifty-Five Years Old Completed NCT02338596 Phase 4
6 Magnolia Study Prolonged Protection From Bone Disease in Multiple Myeloma. An Open Label Phase 3 Multicenter International Randomised Trial Recruiting NCT02286830 Phase 4 Zoledronic acid
7 Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI Recruiting NCT02893293 Phase 4 Ferumoxytol-enhanced magnetic resonance imaging
8 A Multicenter Randomized Controlled Open-label Trial of Conservative Management Versus Minimally Invasive Treatment With Leukocyte- and Platelet-rich Fibrin Versus Primary Surgery in Patients With Newly Diagnosed Osteonecrosis of the Jaw Not yet recruiting NCT04512638 Phase 4 Antibiotics;Chlorhexidine mouthwash
9 A Prospective, Single-center, Non-randomized, Consecutive Series Clinical Study Comparing the Functional Differences Between a Standard Posterior Stabilized Total Knee Replacement and a High-flexion Posterior Stabilized Total Knee Replacement Withdrawn NCT00808613 Phase 4
10 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Unknown status NCT01892514 Phase 3
11 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
12 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
13 Multi-center Clinical Trial of the Application of Ixmyelocel-T in the Treatment of Osteonecrosis of the Femoral Head Completed NCT00505219 Phase 3
14 Aspirin (Acetylsalicylic Acid) in the Prevention of Collapse of the Femoral Head in Early-stage Non-traumatic Osteonecrosis: a Two-year Multicenter, Prospective, Randomized, Double-blind, Placebo-controlled Study Recruiting NCT03405974 Phase 3 Aspirin;Placebo
15 Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment Enrolling by invitation NCT03040778 Phase 3 Pentoxifylline;Placebo;Tocopherol
16 Plasma Rich in Growth Factors for Treatment of Medication Related Osteonecrosis of the Jaw: a Multicenter, Randomized, Clinical Trial Not yet recruiting NCT03390777 Phase 2, Phase 3
17 Phase 3, Pivotal, Multicentre, Randomised, Double-blind Controlled Study to Evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Osteonecrosis of the Femoral Head Terminated NCT01529008 Phase 3 Core decompression/PREOB® implantation;Core decompression/placebo implantation
18 Double Blind Randomized Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis Stage 1 and 2 Terminated NCT02114489 Phase 3 ibandronate;Placebo
19 A Randomised Controlled Trial of Bisphosphonate Therapy in Osteonecrosis of the Hip Unknown status NCT00781261 Phase 2 Zoledronic Acid;Placebo
20 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Unknown status NCT02448121 Phase 1, Phase 2
21 Evaluation of Safety and Performance of Macroporous Biphasic Calcium Phosphate Granules Combined With Cellulosic-Derived Gel, in Filling Bones Gap After Aseptic Osteonecrosis Biopsy of Femur Head. Unknown status NCT00289575 Phase 2
22 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Unknown status NCT02065167 Phase 2
23 Treatment of Osteoporosis With Unfocused Extracorporeal Shock Wave Therapy: Pilot Study Completed NCT02630381 Phase 2
24 PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells Completed NCT01700920 Phase 2
25 A Randomized Controlled Trial of Core Decompression With or Without Cement Packing for Osteonecrosis of the Femoral Head - Long Term Results Completed NCT04233125 Phase 1, Phase 2
26 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
27 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Completed NCT01605383 Phase 1, Phase 2
28 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
29 Effect of Cycle Ergometer in the Rehabilitation of Elderly Patients With Total Hip Arthroplasty: Randomized Controlled Trial Completed NCT01622465 Phase 2
30 Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma Recruiting NCT04401267 Phase 2 Intensive Antihypertensive Therapy;Conventional Antihypertensive Therapy
31 The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSC) Suspended NCT03180463 Phase 1, Phase 2 Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#)
32 AVN Prevention With Lipitor in Lupus Erythematosus APLLE Trial Terminated NCT00412841 Phase 2 Atorvastatin;Placebo
33 A Randomized, Double-blind, Placebo-controlled, Proof of Concept Study of Zoledronic Acid in Spontaneous Osteonecrosis of the Knee (SONK) Withdrawn NCT00477217 Phase 2 Zoledronic acid
34 Intravenous Zoledronic Acid for the Treatment of Osteoporosis and Osteonecrosis in Children With Leukemia: A Pilot Study Withdrawn NCT02632903 Phase 2 Zoledronic acid
35 Phase I Clinical Trial of Use of Autologous Bone Marrow Stem Cells Seeded on Porous Tricalcium Phosphate Matrix and Demineralized Bone Matrix in Patients With Osteonecrosis (MSC/ONM) Unknown status NCT02566681 Phase 1
36 Safety and Efficacy of Hyper Baric Oxygen Therapy (HBOT) in Patients Presenting With Spontaneous Osteonecrosis of the Knee Unknown status NCT01950858 Phase 1
37 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock's Disease) Unknown status NCT02646007 Phase 1
38 Treatment of Osteonecrosis of the Femoral Head With Implantation of Autologous Bone Marrow Cells, a Pilot Study Completed NCT00821470 Phase 1
39 Randomized Controlled Trial of Hyperbaric Oxygen in Patients Who Have Taken Bisphosphonates Completed NCT00462098 Phase 1
40 Bone Marrow Derived CD133+ Stem Cells Transplantation in Femoral Head Osteonecrosis Completed NCT01198080 Phase 1
41 A Phase 1, Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study of the Safety and Tolerability of Intravenous LLP2A-Alendronate in Adult Men and Women With Osteopenia Secondary to Glucocorticoids Active, not recruiting NCT03197623 Phase 1 LLP2A-ALENDRONATE;Placebo
42 Double Blind, Phase I, Randomized, Parallel Group Study of Hip Decompression Compared to Hip Decompression Supplemented at the Point of Care With Adipose Derived Regenerative Cells for Bilateral Pre-Collapse Femoral Head Osteonecrosis Suspended NCT03269409 Phase 1
43 A Comparison of Two Different Surgical Techniques to Preserve the Bony Supply and Improve Implant Longevity in Hip Resurfacing Arthroplasty Unknown status NCT00913679
44 Part I: Incidence, Clinical Course and Significance of MRI for Early Diagnosis of Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL) Part II: Susceptibility for Aseptic Osteonecroses in Children and Adolescents With Chemotherapy for ALL or LBL Unknown status NCT01619124
45 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
46 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Auto Grafting Unknown status NCT02291900
47 Prospective Randomized Clinical Study: Role of Platelet Rich Fibrin (PRF) in the Tooth Extraction Site in the Prevention of Jaw Osteonecrosis on Patients Under Bisphosphonates Therapy Unknown status NCT02198001 tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine)
48 Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay. Unknown status NCT02218554
49 Steroid Induced Osteoporosis in the Pediatric Population Ancillary Study- Osteonecrosis in Children With Acute Lymphoblastic Leukemia Unknown status NCT01104324
50 Molecular Genetic Study of Avascular Necrosis of the Femoral Head-Revealing ANFH Pathogenesis Mechanism by Cell and Animal Models Unknown status NCT00260897

Search NIH Clinical Center for Osteonecrosis

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC, cultured cartilage for chondral lesion
PREOB, autologous osteoblasts for bone disorders
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC) PMIDs: 19393556 10738867 16226641 12043781 16233853 19802670 10679677 11284883 16233778

Cochrane evidence based reviews: osteonecrosis

Genetic Tests for Osteonecrosis

Genetic tests related to Osteonecrosis:

# Genetic test Affiliating Genes
1 Avascular Necrosis of Bone 29

Anatomical Context for Osteonecrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteonecrosis:


MalaCards organs/tissues related to Osteonecrosis:

Bone, Bone Marrow, Breast, Endothelial, Prostate, Kidney, Liver

Publications for Osteonecrosis

Articles related to Osteonecrosis:

(show top 50) (show all 11674)
# Title Authors PMID Year
Bisphosphonate for spontaneous osteonecrosis of the knee: A protocol for systematic review and meta-analysis of randomized controlled trials. 42 61
33285686 2020
Development and validation of a nomogram for predicting the probability of nontraumatic osteonecrosis of the femoral head in Chinese population. 61 42
33244062 2020
Shotgun metagenome sequencing identification of a set of genes encoded by Actinomyces associated with medication-related osteonecrosis of the jaw. 61 42
33253207 2020
The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials. 61
33336610 2021
Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts. 61
33553512 2021
Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307). 61
32929540 2021
Prevalence of medication related osteonecrosis of the jaw in patients treated with sequential antiresorptive drugs: systematic review and meta-analysis. 61
33190182 2021
An MSC bone-homing compound, Rab001, increases bone mass and reduces the incidence of osteonecrosis in a glucocorticoid-induced osteonecrosis mouse model. 61
33319413 2021
Do irradiated osteo-articular recycled tumor autografts still hold promise for biological joint reconstruction? Our experience with acetabular and proximal ulna ECRT. 61
33717950 2021
Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols. 61
32646890 2021
Distance to the pediatric oncology center does not affect survival in children with acute lymphoblastic leukemia: a report from CYP-C. 61
33231123 2021
The Use of Biologics for Hip Preservation. 61
33483876 2021
Osteonecrosis in Adults With Acute Lymphoblastic Leukemia: An Unmet Clinical Need. 61
33718802 2021
Total Hip Arthroplasty in Adolescents and Young Adults for Management of Advanced Corticosteroid-Induced Osteonecrosis Secondary to Treatment for Hematologic Malignancies. 61
33281023 2021
Bone single-photon emission computed tomography-CT peak standardized uptake value for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw. 61
33180378 2021
The role, efficacy and outcome measures for teriparatide use in the management of medication-related osteonecrosis of the jaw. 61
32800674 2021
Long-term outcomes of curved intertrochanteric varus osteotomy combined with bone impaction grafting for non-traumatic osteonecrosis of the femoral head. 61
33789486 2021
Bisphosphonate Therapy for Treating Osteonecrosis in Pediatric Leukemia Patients: A Systematic Review. 61
32324697 2021
Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris). 61
33515777 2021
Reciprocal effect of microRNA-224 on osteogenesis and adipogenesis in steroid-induced osteonecrosis of the femoral head. 61
33453444 2021
Comparison of Radiographic and Pathologic Diagnosis of Osteonecrosis of the Femoral Head. 61
33534621 2021
Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages. 61
33563553 2021
Is medication-related osteonecrosis of the jaw associated with tumor necrosis factor-α inhibition? 61
33408034 2021
Medication-related osteonecrosis of the mandible: an unusual presentation and treatment. 61
32847710 2021
Percutaneous Radiofrequency Ablation of Appendicular Skeleton Chondroblastoma-an Experience from a Tertiary Care Cancer Center. 61
33612370 2021
miR-27a promotes osteogenic differentiation in glucocorticoid-treated human bone marrow mesenchymal stem cells by targeting PI3K. 61
33532936 2021
Bisphosphonate Drug Holidays in Primary Care: When and What to Do Next? 61
33528743 2021
Antioxidant and anti-sickling activity of glucal-based triazoles compounds - An in vitro and in silico study. 61
33636439 2021
Closed Pantalar Dislocations: Characteristics, Treatment Approaches, and Outcomes. 61
33475300 2021
Short-Term Outcomes of Total Hip Arthroplasty after Liver Transplantation. 61
33665276 2021
Finite element simulation and integration of CEM43 °C and Arrhenius Models for ultrasonic-assisted skull bone grinding: A thermal dose model. 61
33781484 2021
Histological evaluation of thermal damage to Osteocytes: A comparative study of conventional and ultrasonic-assisted bone grinding. 61
33781475 2021
Effect of the use of a surgical guide on heat generation during implant placement: A comparative in vitro study. 61
33754500 2021
Analysis of factors determining thermal changes at osteotomy site in dental implant placement - An in-vitro study. 61
33680325 2021
Antiresorptive agent-related osteonecrosis of the jaw in prostate cancer patients with bone metastasis treated with bone-modifying agents. 61
32886176 2021
Influence of prostate cancer status on the prevalence of medication-related osteonecrosis of the jaw. 61
33431343 2021
Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model. 61
33786320 2021
Safety of Intravenous Bisphosphonates for the Treatment of Hypercalcemia in Patients With Preexisting Renal Dysfunction. 61
32847379 2021
[Atypical arthritis of the hands : Collagenosis-part 1]. 61
33779767 2021
[Relationship and risk factors of osteonecrosis of femoral head after internal fixation of femoral neck fracture with serum bone metabolism and vasoactive factors]. 61
33787163 2021
CaO2/gelatin oxygen slow-releasing microspheres facilitate tissue engineering efficiency for the osteonecrosis of femoral head by enhancing the angiogenesis and survival of grafted bone marrow mesenchymal stem cells. 61
33651043 2021
Potential roles of extracellular vesicles in osteonecrosis of femoral head: A systematic review. 61
33359121 2021
[Experimental study on improvement of osteonecrosis of femoral head with exosomes derived from miR-27a-overexpressing vascular endothelial cells]. 61
33719246 2021
CircRNA_25487 inhibits bone repair in trauma-induced osteonecrosis of femoral head by sponging miR-134-3p through p21. 61
33426239 2021
Hip pathologies in mucopolysaccharidosis type III. 61
33741007 2021
Comment on: "Team approach: Management of osteonecrosis in children with acute lymphoblastic leukemia: An ounce of prevention is worth a pound of cure: Consideration of prophylactic pamidronate. 61
33047874 2021
Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations. 61
33106839 2021
Bone pain at leukemia diagnosis and other risk factors for symptomatic osteonecrosis in children with acute lymphoblastic leukemia. 61
33788395 2021
Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits. 61
33681418 2021
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling. 61
33147653 2021

Variations for Osteonecrosis

Expression for Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for Osteonecrosis

Pathways related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
Show member pathways
4 11.77 TNF BMP7 BMP2
Show member pathways
11.63 RUNX2 BMP7 BMP2
Show member pathways
11.56 CYP3A4 CYP2C8 ABCB1
Show member pathways
11.54 CYP3A4 CYP2C8 ABCB1
Show member pathways
11.5 CYP3A4 CYP2C8 ABCB1
Show member pathways
11.42 CYP3A4 CYP2C8 ABCB1
16 11.37 VEGFA TNFSF11 DKK1
18 11.33 VEGFA NFATC1 BMP2
20 10.92 TNFSF11 TNF COL2A1 BMP7 BMP2
21 10.79 CYP3A4 CYP2C8 ABCB1
23 10.73 DKK1 BMP2
24 10.73 TNFSF11 PTH BGLAP
25 10.61 CYP3A4 ABCB1

GO Terms for Osteonecrosis

Cellular components related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TNFSF11 TNF SERPINE1 PTH F2
2 extracellular space GO:0005615 9.36 VEGFA TNFSF11 TNF SERPINE1 PTH F2

Biological processes related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.11 VEGFA TNFSF11 TNF LRP5 F2 DKK1
2 positive regulation of transcription, DNA-templated GO:0045893 10.06 TNF RUNX2 NFATC1 LRP5 BMP7 BMP2
3 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA TNF F2 BMP2
4 positive regulation of gene expression GO:0010628 9.87 VEGFA TNFSF11 TNF RUNX2 DKK1 BMP7
5 animal organ morphogenesis GO:0009887 9.85 TNFSF11 TNF BMP7 BMP2
6 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 VEGFA TNFSF11 TNF SERPINE1 RUNX2 PTH
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.84 VEGFA TNF F2
8 BMP signaling pathway GO:0030509 9.83 RUNX2 BMP7 BMP2
9 cartilage development GO:0051216 9.82 COL2A1 BMP7 BMP2
10 positive regulation of MAP kinase activity GO:0043406 9.77 VEGFA TNFSF11 TNF
11 odontogenesis of dentin-containing tooth GO:0042475 9.75 RUNX2 BMP7 BMP2
12 positive regulation of osteoblast differentiation GO:0045669 9.73 RUNX2 LRP5 BMP7 BMP2
13 chondrocyte differentiation GO:0002062 9.71 RUNX2 COL2A1 BMP2
14 positive regulation of bone mineralization GO:0030501 9.7 PTH BMP7 BMP2
15 bone resorption GO:0045453 9.67 TNFSF11 PTH ACP5
16 bone development GO:0060348 9.67 TNFSF11 LRP5 COL2A1 BGLAP
17 positive regulation of osteoblast proliferation GO:0033690 9.65 LRP5 BMP2
18 embryonic skeletal joint morphogenesis GO:0060272 9.65 COL2A1 BMP7
19 negative regulation of fibrinolysis GO:0051918 9.65 SERPINE1 F2
20 response to vitamin D GO:0033280 9.65 PTH BMP7 BGLAP
21 negative regulation of cardiac muscle cell differentiation GO:2000726 9.64 DKK1 BMP2
22 negative regulation of vascular wound healing GO:0061044 9.63 TNF SERPINE1
23 mesenchymal cell differentiation GO:0048762 9.63 BMP7 BMP2
24 osteoblast development GO:0002076 9.63 RUNX2 LRP5 BGLAP
25 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.62 RUNX2 BMP2
26 proteoglycan metabolic process GO:0006029 9.62 COL2A1 BMP2
27 endocardial cushion formation GO:0003272 9.61 BMP7 BMP2
28 lipid hydroxylation GO:0002933 9.6 CYP3A4 CYP2C8
29 regulation of osteoclast differentiation GO:0045670 9.58 TNFSF11 TNF BGLAP
30 mesenchyme development GO:0060485 9.57 BMP7 BMP2
31 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.56 RUNX2 BMP2
32 cellular response to BMP stimulus GO:0071773 9.56 RUNX2 COL2A1 BMP7 BMP2
33 skeletal system development GO:0001501 9.43 RUNX2 PTH COL2A1 BMP7 BMP2 BGLAP
34 ossification GO:0001503 9.17 TNFSF11 RUNX2 COL2A1 BMP7 BMP2 BGLAP

Molecular functions related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 9.4 BMP7 BMP2
2 co-receptor binding GO:0039706 9.37 DKK1 BMP2
3 cytokine activity GO:0005125 9.35 VEGFA TNFSF11 TNF BMP7 BMP2
4 retinoic acid 4-hydroxylase activity GO:0008401 9.32 CYP3A4 CYP2C8
5 estrogen 16-alpha-hydroxylase activity GO:0101020 9.26 CYP3A4 CYP2C8
6 caffeine oxidase activity GO:0034875 9.16 CYP3A4 CYP2C8
7 growth factor activity GO:0008083 9.02 VEGFA F2 DKK1 BMP7 BMP2

Sources for Osteonecrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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