MCID: OST003
MIFTS: 60

Osteonecrosis

Categories: Blood diseases, Bone diseases, Rare diseases
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Aliases & Classifications for Osteonecrosis

MalaCards integrated aliases for Osteonecrosis:

Name: Osteonecrosis 11 58 75 41 43 14 36 16 75 31 33
Bone Necrosis 11 58 71 33
Avascular Necrosis of Bone 11 33
Aseptic Necrosis of Bone, Site Unspecified 33
Aseptic or Avascular Bone Necrosis 33
Spontaneous Osteonecrosis 33
Aseptic Necrosis of Bone 33
Aseptic Osteonecrosis 33
Necrosis of Bone Nos 33
Osteoradionecrosis 33
Aseptic Necrosis 11
Necrotizing Bone 33
Necrotic Bone 33

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 11 DOID:10159
MeSH 43 D010020
ICD10 via Orphanet 32 M87.0 M87.1 M87.2 more
UMLS via Orphanet 72 C0029445
Orphanet 58 ORPHA399158
UMLS 71 C0003977 C0027543 C0029445 more

Summaries for Osteonecrosis

MedlinePlus: 41 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down. You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well. No one is sure what causes the disease. Risk factors include : Long-term steroid treatment Alcohol misuse Joint injuries Having certain diseases, including arthritis and cancer Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary: Osteonecrosis, also known as bone necrosis, is related to osteonecrosis of the jaw and osteomyelitis, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Osteonecrosis is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Signal Transduction and Extracellular matrix organization. The drugs Pentoxifylline and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology: 11 An ischemic bone disease that results in necrosis located in bone.

Wikipedia: 75 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Osteonecrosis

Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 964)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis of the jaw 33.0 VEGFA NFATC1 CYP2C8
2 osteomyelitis 31.4 NFATC1 BMP2 ACP5
3 thrombophilia due to thrombin defect 31.0 SERPINE1 MTHFR F2
4 osteoarthritis 31.0 RUNX2 COL2A1 BMP2 BGLAP
5 cartilage disease 31.0 RUNX2 COL2A1 BMP2
6 myeloma, multiple 30.9 VEGFA MIR17 FGF2 BGLAP ACP5 ABCB1
7 osteochondrosis 30.9 PTH COL2A1 BMP2
8 antiphospholipid syndrome 30.8 SERPINE1 MTHFR F2
9 periodontitis 30.7 RUNX2 MIR17 BGLAP ACP5
10 endosteal hyperostosis, autosomal dominant 30.7 PTH NFATC1 LRP5 BMP2 ACP5
11 protein s deficiency 30.6 SERPINE1 MTHFR F2
12 mucositis 30.6 VEGFA MTHFR ABCB1
13 protein c deficiency 30.6 SERPINE1 MTHFR F2
14 beta-thalassemia 30.6 MTHFR F2 ESR1 BGLAP
15 exostosis 30.5 RUNX2 COL2A1 BMP2 BGLAP
16 arthropathy 30.5 COL2A1 BMP7 BMP2
17 thrombophilia due to activated protein c resistance 30.5 SERPINE1 MTHFR F2
18 osteochondritis dissecans 30.5 COL2A1 BMP7 BMP2
19 pulmonary embolism 30.5 SERPINE1 MTHFR F2
20 renal osteodystrophy 30.5 PTH BGLAP ACP5
21 hyperparathyroidism 30.4 PTH BGLAP ACP5
22 periapical periodontitis 30.3 RUNX2 BGLAP ACP5
23 vascular disease 30.3 VEGFA SERPINE1 MTHFR FGF2 F2 ESR1
24 kidney cancer 30.3 VEGFA MIR210 MIR17 FGF2 ABCB1
25 nutritional deficiency disease 30.3 MTHFR F2 BGLAP
26 mammary paget's disease 30.3 RUNX2 PTH NFATC1 FDPS ESR1 BGLAP
27 thrombophlebitis 30.3 SERPINE1 MTHFR F2
28 gorham's disease 30.2 VEGFA PTH
29 osseous heteroplasia, progressive 30.2 RUNX2 PTH BMP7 BMP2 BGLAP
30 osteopetrosis 30.2 RUNX2 NFATC1 LRP5 BGLAP ACP5
31 bone inflammation disease 30.2 VEGFA MIR210 MIR17 COL2A1 ACP5
32 vitamin k deficiency bleeding 30.2 PTH F2 BGLAP
33 paget's disease of bone 30.2 PTH NFATC1 FDPS BGLAP ACP5
34 osteoporosis, juvenile 30.2 RUNX2 PTH LRP5 BGLAP
35 buerger disease 30.1 VEGFA FGF2 F2
36 mccune-albright syndrome 30.1 PTH LRP5 COL2A1
37 eclampsia 30.0 VEGFA MTHFR F2
38 migraine with or without aura 1 30.0 VEGFA MTHFR F2 ESR1
39 pre-eclampsia 30.0 VEGFA SERPINE1 MTHFR MIR210 F2
40 peripheral vascular disease 30.0 VEGFA SERPINE1 MTHFR F2
41 microvascular complications of diabetes 5 30.0 VEGFA SERPINE1 MIR17 FGF2
42 hellp syndrome 30.0 VEGFA SERPINE1 MTHFR F2
43 spondylolysis 30.0 PTH BMP7 BMP2
44 kohler's disease 29.9 PTH COL2A1
45 cerebrovascular disease 29.9 MTHFR MIR210 MIR17 F2
46 hemangioma 29.9 VEGFA FGF2 F2 ESR1
47 bone giant cell tumor 29.9 RUNX2 PTH ACP5
48 arteriosclerosis 29.9 SERPINE1 RUNX2 MIR210 FGF2
49 secondary hyperparathyroidism 29.9 PTH BMP7 BGLAP ACP5
50 inflammatory bowel disease 29.8 NFATC1 MTHFR F2 BMP7 BGLAP ABCB1

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to Osteonecrosis

Symptoms & Phenotypes for Osteonecrosis

UMLS symptoms related to Osteonecrosis:


back pain; sciatica; muscle cramp

MGI Mouse Phenotypes related to Osteonecrosis:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ABCB1 BGLAP BMP2 BMP7 COL2A1 ESR1
2 growth/size/body region MP:0005378 10.34 ABCB1 BMP2 BMP7 COL2A1 ESR1 F2
3 limbs/digits/tail MP:0005371 10.26 ACP5 BMP2 BMP7 COL2A1 ESR1 LRP5
4 cardiovascular system MP:0005385 10.25 ABCB1 BMP2 BMP7 COL2A1 ESR1 F2
5 immune system MP:0005387 10.24 ABCB1 ACP5 BGLAP BMP2 BMP7 COL2A1
6 cellular MP:0005384 10.21 BGLAP BMP2 COL2A1 ESR1 F2 FDPS
7 liver/biliary system MP:0005370 10.19 ABCB1 COL2A1 ESR1 LRP5 MTHFR NFATC1
8 muscle MP:0005369 10.15 ESR1 F2 FDPS FGF2 NFATC1 RUNX2
9 digestive/alimentary MP:0005381 10.13 ABCB1 BMP2 BMP7 COL2A1 ESR1 F2
10 craniofacial MP:0005382 10.06 BMP2 BMP7 COL2A1 LRP5 NFATC1 PTH
11 skeleton MP:0005390 10.03 ACP5 BGLAP BMP2 BMP7 COL2A1 ESR1
12 reproductive system MP:0005389 9.96 ABCB1 BGLAP BMP2 BMP7 ESR1 F2
13 respiratory system MP:0005388 9.92 BMP7 COL2A1 ESR1 F2 NFATC1 RUNX2
14 hematopoietic system MP:0005397 9.83 ABCB1 ACP5 BGLAP BMP2 BMP7 ESR1
15 mortality/aging MP:0010768 9.53 ABCB1 BMP2 BMP7 COL2A1 ESR1 F2

Drugs & Therapeutics for Osteonecrosis

Drugs for Osteonecrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
2
Tocopherol Approved, Investigational Phase 4 1406-66-2
3
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9, 24729-96-2 29029
7
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
9
DL-alpha-Tocopherol Approved, Experimental, Investigational, Nutraceutical, Vet_approved Phase 4 59-02-9, 10191-41-0 2116 14985
10
Tocotrienol Investigational Phase 4 6829-55-6 9929901
11 Radiation-Protective Agents Phase 4
12 Vitamins Phase 4
13 Trace Elements Phase 4
14 Phosphodiesterase Inhibitors Phase 4
15 Vasodilator Agents Phase 4
16 Platelet Aggregation Inhibitors Phase 4
17 Antioxidants Phase 4
18 Micronutrients Phase 4
19 Protective Agents Phase 4
20 Tocotrienols Phase 4
21 Tocopherols Phase 4
22 Anesthetics Phase 4
23 Parenteral Nutrition Solutions Phase 4
24 Ferrosoferric Oxide Phase 4
25 Hematinics Phase 4
26 Antibiotics, Antitubercular Phase 4
27 Anti-Bacterial Agents Phase 4
28 Penicillins Phase 4
29 Anti-Infective Agents, Local Phase 4
30
Clindamycin phosphate Phase 4 32603
31 Clindamycin palmitate Phase 4
32 Chlorhexidine gluconate Phase 4
33 Disinfectants Phase 4
34 Amoxicillin-Potassium Clavulanate Combination Phase 4
35 Anti-Infective Agents Phase 4
36 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
37
Acetylsalicylic acid Approved, Vet_approved Phase 3 50-78-2 2244
38
Ibandronate Approved, Investigational Phase 3 114084-78-5 60852
39
Coal tar Approved Phase 2, Phase 3 8007-45-2
40 Analgesics Phase 3
41 Antirheumatic Agents Phase 3
42 Fibrinolytic Agents Phase 3
43 Antipyretics Phase 3
44 Cyclooxygenase Inhibitors Phase 3
45 Anti-Inflammatory Agents, Non-Steroidal Phase 3
46 Analgesics, Non-Narcotic Phase 3
47 Keratolytic Agents Phase 2, Phase 3
48 Dermatologic Agents Phase 2, Phase 3
49
Atorvastatin Approved Phase 2 134523-00-5 60823
50 Polymethyl Methacrylate Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 136)
# Name Status NCT ID Phase Drugs
1 Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis Unknown status NCT00265252 Phase 4 Alendronate
2 Comparison of the Outcomes of Ultra-Short Anatomic and Conventional Cementless Stems in Patients Younger Than Fifty-Five Years Old Completed NCT02338596 Phase 4
3 Comparison of Ceramic-on-Ceramic and Ceramic-on-Highly-Cross-Linked Polyethylene Bearings in Primary Cementless Total Hip Arthroplasty in the Same Patients Completed NCT01806766 Phase 4
4 A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients Completed NCT01345097 Phase 4
5 Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment Completed NCT02368457 Phase 4 Pentoxifylline and Tocopherol
6 Serial Magnetic Resonance Imaging of Longitudinal Radiotherapy-Attributable Normal Tissue Injury Recruiting NCT04265430 Phase 4
7 Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI Enrolling by invitation NCT02893293 Phase 4 Ferumoxytol-enhanced magnetic resonance imaging
8 A Multicenter Randomized Controlled Open-label Trial of Conservative Management Versus Minimally Invasive Treatment With Leukocyte- and Platelet-rich Fibrin Versus Primary Surgery in Patients With Newly Diagnosed Osteonecrosis of the Jaw Not yet recruiting NCT04512638 Phase 4 Antibiotics;Chlorhexidine mouthwash
9 Aspirin (Acetylsalicylic Acid) in the Prevention of Collapse of the Femoral Head in Early-stage Non-traumatic Osteonecrosis: a Two-year Multicenter, Prospective, Randomized, Double-blind, Placebo-controlled Study Unknown status NCT03405974 Phase 3 Aspirin;Placebo
10 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Unknown status NCT01892514 Phase 3
11 Plasma Rich in Growth Factors for Treatment of Medication Related Osteonecrosis of the Jaw: a Multicenter, Randomized, Clinical Trial Unknown status NCT03390777 Phase 2, Phase 3
12 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
13 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
14 Multi-center Clinical Trial of the Application of Ixmyelocel-T in the Treatment of Osteonecrosis of the Femoral Head Completed NCT00505219 Phase 3
15 Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment Enrolling by invitation NCT03040778 Phase 3 Pentoxifylline;Placebo;Tocopherol
16 Double Blind Randomized Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis Stage 1 and 2 Terminated NCT02114489 Phase 3 ibandronate;Placebo
17 Phase 3, Pivotal, Multicentre, Randomised, Double-blind Controlled Study to Evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Osteonecrosis of the Femoral Head Terminated NCT01529008 Phase 3 Core decompression/PREOB® implantation;Core decompression/placebo implantation
18 Efficacy of Adding Hyperbaric Oxygen Therapy to the Treatment of Late Radiation Damage of the Lower Jaw (Osteoradionecrosis). Terminated NCT00989820 Phase 2, Phase 3 hyperbaric oxygen
19 A Randomised Controlled Trial of Bisphosphonate Therapy in Osteonecrosis of the Hip Unknown status NCT00781261 Phase 2 Zoledronic Acid;Placebo
20 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Unknown status NCT02448121 Phase 1, Phase 2
21 Evaluation of Safety and Performance of Macroporous Biphasic Calcium Phosphate Granules Combined With Cellulosic-Derived Gel, in Filling Bones Gap After Aseptic Osteonecrosis Biopsy of Femur Head. Unknown status NCT00289575 Phase 2
22 Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study Unknown status NCT00760682 Phase 2
23 PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells Completed NCT01700920 Phase 2
24 A Randomized Controlled Trial of Core Decompression With or Without Cement Packing for Osteonecrosis of the Femoral Head - Long Term Results Completed NCT04233125 Phase 1, Phase 2
25 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Completed NCT01605383 Phase 1, Phase 2
26 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
27 Effect of Cycle Ergometer in the Rehabilitation of Elderly Patients With Total Hip Arthroplasty: Randomized Controlled Trial Completed NCT01622465 Phase 2
28 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Completed NCT02065167 Phase 2
29 Pilot Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed NCT01336803 Phase 2 Feraheme
30 Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma Recruiting NCT04401267 Phase 2 Intensive Antihypertensive Therapy;Conventional Antihypertensive Therapy
31 The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSC) Suspended NCT03180463 Phase 1, Phase 2 Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#)
32 OZOPROMAF: Validation Study of the Use of Ozonotherapy in Mronj Management- Protocol of Ozone by Infiltrations in Patients With Osteonecrosis of the Jaws Drug Related Suspended NCT05036837 Phase 1, Phase 2 OZOPROMAF_SEQ1
33 AVN Prevention With Lipitor in Lupus Erythematosus APLLE Trial Terminated NCT00412841 Phase 2 Atorvastatin;Placebo
34 Intravenous Zoledronic Acid for the Treatment of Osteoporosis and Osteonecrosis in Children With Leukemia: A Pilot Study Withdrawn NCT02632903 Phase 2 Zoledronic acid
35 A Randomized, Double-blind, Placebo-controlled, Proof of Concept Study of Zoledronic Acid in Spontaneous Osteonecrosis of the Knee (SONK) Withdrawn NCT00477217 Phase 2 Zoledronic acid
36 Phase I Clinical Trial of Use of Autologous Bone Marrow Stem Cells Seeded on Porous Tricalcium Phosphate Matrix and Demineralized Bone Matrix in Patients With Osteonecrosis (MSC/ONM) Unknown status NCT02566681 Phase 1
37 Safety and Efficacy of Hyper Baric Oxygen Therapy (HBOT) in Patients Presenting With Spontaneous Osteonecrosis of the Knee Unknown status NCT01950858 Phase 1
38 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock's Disease) Unknown status NCT02646007 Phase 1
39 Treatment of Osteonecrosis of the Femoral Head With Implantation of Autologous Bone Marrow Cells, a Pilot Study Completed NCT00821470 Phase 1
40 Bone Marrow Derived CD133+ Stem Cells Transplantation in Femoral Head Osteonecrosis Completed NCT01198080 Phase 1
41 Randomized Controlled Trial of Hyperbaric Oxygen in Patients Who Have Taken Bisphosphonates Completed NCT00462098 Phase 1
42 A Phase 1, Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study of the Safety and Tolerability of Intravenous LLP2A-Alendronate in Adult Men and Women With Osteopenia Secondary to Glucocorticoids Completed NCT03197623 Phase 1 LLP2A-ALENDRONATE;Placebo
43 Double Blind, Phase I, Randomized, Parallel Group Study of Hip Decompression Compared to Hip Decompression Supplemented at the Point of Care With Adipose Derived Regenerative Cells for Bilateral Pre-Collapse Femoral Head Osteonecrosis Terminated NCT03269409 Phase 1
44 The British Osteonecrosis Study: A Prospective Multi-centre Study to Examine the Natural History of Osteonecrosis in Older Children, Teenagers and Young Adults With Acute Lymphoblastic Leukaemia and Lymphoblastic Lymphoma Unknown status NCT02598401
45 Prospective Randomized Clinical Study: Role of Platelet Rich Fibrin (PRF) in the Tooth Extraction Site in the Prevention of Jaw Osteonecrosis on Patients Under Bisphosphonates Therapy Unknown status NCT02198001 tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine)
46 Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay. Unknown status NCT02218554
47 Mesenchymal Stem Cell Transplantation in the Treatment of Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
48 Local Administration of Enriched Mononuclear Cells, Platelets and Zoledronic Acid for Preventing Collapse of the Femoral Head in the Early Stage of Osteonecrosis: a Prospective, Randomized, Parallel-controlled Clinical Trial Unknown status NCT02721940 Zoledronic Acid;Normal saline
49 The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw Unknown status NCT03418454
50 Steroid Induced Osteoporosis in the Pediatric Population Ancillary Study- Osteonecrosis in Children With Acute Lymphoblastic Leukemia Unknown status NCT01104324

Search NIH Clinical Center for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC, cultured cartilage for chondral lesion
PREOB, autologous osteoblasts for bone disorders
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC) PMIDs: 19393556 10738867 16226641 12043781 16233853 10679677 16233778 19802670 11284883

Cochrane evidence based reviews: osteonecrosis

Genetic Tests for Osteonecrosis

Anatomical Context for Osteonecrosis

Organs/tissues related to Osteonecrosis:

FMA: Bone
MalaCards : Bone, Bone Marrow, Skin, Breast, Endothelial, Tongue, Prostate

Publications for Osteonecrosis

Articles related to Osteonecrosis:

(show top 50) (show all 16241)
# Title Authors PMID Year
1
Bone Concentration of Ampicillin/Sulbactam: A Pilot Study in Patients with Osteonecrosis of the Jaw. 62 41
36429636 2022
2
A review and meta-analysis of the survival rate of adult with osteonecrosis of the femoral head treated with transtrochanteric rotational osteotomy. 62 41
36451500 2022
3
Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs. 62 41
36380019 2022
4
Successful Hypoglossal Nerve Upper Airway Stimulator Implantation After Chemoradiotherapy for Oropharynx Malignancy Complicated by Mandibular Osteoradionecrosis. 62
33405965 2023
5
Process of Hard Palate Osteonecrosis Demonstrated on Serial 18F-FDG PET/CT Scans. 62
36469079 2023
6
A Custom Mouthpiece With Lip Bumper for Osteoradionecrosis Risk Reduction After Carbon-Ion Radiation Therapy for Adenoid Cystic Carcinoma of the Lip. 62
36471821 2023
7
Quantitative Real-Time Gene Profiling of Human Alveolar Osteoblasts Using a One-Step System. 62
36418701 2023
8
Skeletal Outcomes in Children and Young Adults with Glomerular Disease. 62
36171052 2022
9
World Workshop on Oral Medicine VII: Oral adverse effects to biologic agents in patients with inflammatory disorders. A scoping review. 62
36455995 2022
10
Clinical applications of adipose-derived stromal vascular fraction in veterinary practice. 62
35841195 2022
11
Feasibility of Magnetic Resonance-Guided High-Intensity-Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain. 62
35633227 2022
12
Long-Term Outcomes of Arthroscope-Assisted Bone-Ligament-Bone Reconstruction for Nonstatic Scapholunate Ligament Injury. 62
36126203 2022
13
Atorvastatin reduces zoledronic acid-induced osteonecrosis of the jaws of rats. 62
36150658 2022
14
Platelet-derived growth factors from a single donor by apheresis and one freeze-thaw cycle for treating medication-related osteonecrosis of the jaw. 62
36169261 2022
15
Ex vivo Study of Detergent-Assisted Intraosseous Bone Wash Treatment of Osteonecrosis. 62
36453529 2022
16
Long-term outcomes after humeral head replacement and total shoulder replacement for osteonecrosis of the humeral head: a mean follow-up of 8 years. 62
36471020 2022
17
RE: American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update: Quantitative Risk Assessment and Controversial Issues. 62
36464425 2022
18
The potential effect of BMSCs with miR-27a in improving steroid-induced osteonecrosis of the femoral head. 62
36473889 2022
19
The Role of Bone Grafts in Preventing Medication-Related Osteonecrosis of the Jaw: Histomorphometric, Immunohistochemical, and Clinical Evaluation in Animal Model. 62
36387320 2022
20
Incidence and risk factors for medication-related osteonecrosis after tooth extraction in cancer patients-A systematic review. 62
36464958 2022
21
Correction to: Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw. 62
34841455 2022
22
Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice. 62
36069912 2022
23
Accuracy and outcomes of virtual surgical planning and 3D-printed guides for osseous free flap reconstruction of mandibular osteoradionecrosis. 62
36384079 2022
24
Autologous platelet concentrates in extraction sockets for the prevention of osteoradionecrosis: a systematic review of controlled clinical trials. 62
35048208 2022
25
The role of hyperbaric oxygen therapy in the treatment of radiation lesions. 62
35976581 2022
26
The clinical effect of radiotherapy on pulpal microvasculature: a systematic review. 62
36473977 2022
27
Evaluation of advanced platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam. 62
35941396 2022
28
Osteonecrosis of the Jaw Caused by Denosumab in Treatment-Naïve and Pre-Treatment with Zoledronic Acid Groups: A Time-to-Onset Study Using the Japanese Adverse Drug Event Report (JADER) Database. 62
35933498 2022
29
Bone marrow mesenchymal stem cells-derived exosomes mediate nuclear receptor coactivator-3 expression in osteoblasts by delivering miR-532-5p to influence osteonecrosis of the femoral head development. 62
36116109 2022
30
Assessment of clinical guidelines for medication-related osteonecrosis of the jaw: current status and future directions. 62
36241597 2022
31
Convolutional neural network for automated classification of osteonecrosis and related mandibular trabecular patterns. 62
36389628 2022
32
Long-term experience with intraoperative electron radiation therapy boost in extremity sarcoma. 62
35856506 2022
33
Molecular Quantity Variations in Human-Mandibular-Bone Osteoid. 62
35978052 2022
34
Analysis of Factors Influencing Postoperative Femoral Head Collapse in Patients With Ficat I, II, and III Stages of Aseptic Necrosis of the Femoral Head. 62
36107128 2022
35
Response to: Prognosis of metastatic bone cancer and myeloma patients and long‑term risk of medication‑related osteonecrosis of the jaw (MRONJ): some critical points. 62
36318340 2022
36
Prognosis of metastatic bone cancer and myeloma patients and long-term risk of medication-related osteonecrosis of the jaw (MRONJ): some critical points. 62
35882670 2022
37
Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw. 62
36345763 2022
38
Osteoradionecrosis versus Cancer Recurrence: An Unresolved Clinical Dilemma. 62
36455537 2022
39
Volume and location of bone regeneration after autologous expanded mesenchymal stromal cells in hip osteonecrosis : a pilot study. 62
36464628 2022
40
Clinical Vignettes, Part II: Eyes, Teeth, and Bone. 62
36400539 2022
41
Debilitating hip degeneration in trichothiodystrophy: Association with ERCC2/XPD mutations, osteosclerosis, osteopenia, coxa valga, contractures, and osteonecrosis. 62
36103153 2022
42
Outcomes of free vascularized iliac bone flap for severe traumatic osteonecrosis of femoral head in young adults. 62
36469082 2022
43
A systematic review and meta-analysis of interventional studies of bisphosphonates and denosumab in multiple myeloma and future perspectives. 62
36458395 2022
44
ACR Appropriateness Criteria® Osteonecrosis: 2022 Update. 62
36436966 2022
45
Etiology of avascular necrosis of the hip and shoulder. Screening for Gaucher disease. 62
36457211 2022
46
Hyperbaric oxygen therapy in stage III C Kienböck disease: Time is bone. 62
36415715 2022
47
Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis. 62
36429946 2022
48
A comparative study of the clinical characteristics of patients with medication-related osteonecrosis of the jaw and osteoporosis or malignancy. 62
35668004 2022
49
Incidence and risk factors associated to Medication-Related Osteo Necrosis of the Jaw (MRONJ) in patients with osteoporosis after tooth extractions. A 12-months observational cohort study. 62
35609780 2022
50
Long-term consequences of osteoporosis therapy with denosumab. 62
36382761 2022

Variations for Osteonecrosis

Expression for Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for Osteonecrosis

Pathways related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 13.37 VEGFA SERPINE1 PTH NFATC1 LRP5 FGF2
2
Show member pathways
12.52 SERPINE1 FGF2 COL2A1 BMP7 BMP2
3 12 PTH LRP5 BGLAP ABCB1
4 11.74 FGF2 COL2A1 BMP7
5 11.61 VEGFA FGF2 BMP2
6 11.57 SERPINE1 RUNX2 ESR1
7
Show member pathways
11.53 VEGFA RUNX2 PTH FGF2 COL2A1 BMP7
8 11.5 VEGFA SERPINE1 ABCB1
10 11.46 RUNX2 PTH NFATC1 LRP5 BMP2
11 11.39 VEGFA FGF2 COL2A1
12 11.25 BMP2 NFATC1 VEGFA
13 11.2 RUNX2 PTH BGLAP
14 11.15 RUNX2 PTH FGF2 COL2A1 BMP7 BMP2
15 11.09 RUNX2 PTH BGLAP
16 10.75 CYP2C8 ABCB1
17 10.74 ESR1 ABCB1
18 10.63 RUNX2 BMP2

GO Terms for Osteonecrosis

Cellular components related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.62 VEGFA SERPINE1 PTH MIR210 MIR17 FGF2

Biological processes related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.46 RUNX2 NFATC1 LRP5 FGF2 ESR1 BMP7
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.46 BMP2 BMP7 ESR1 FGF2 LRP5 NFATC1
3 positive regulation of cell population proliferation GO:0008284 10.37 VEGFA RUNX2 LRP5 FGF2 F2 BMP2
4 positive regulation of gene expression GO:0010628 10.29 VEGFA RUNX2 PTH MIR17 FGF2 BMP7
5 positive regulation of angiogenesis GO:0045766 10.18 VEGFA SERPINE1 MIR210 FGF2
6 osteoblast differentiation GO:0001649 10.15 RUNX2 FGF2 BMP2 BGLAP
7 negative regulation of gene expression GO:0010629 10.14 VEGFA PTH MIR17 FGF2 ESR1 BMP2
8 bone mineralization GO:0030282 10.11 PTH BMP2 BGLAP
9 stem cell proliferation GO:0072089 10.1 ABCB1 FGF2 RUNX2
10 positive regulation of bone mineralization GO:0030501 10.08 PTH BMP7 BMP2
11 positive regulation of blood vessel endothelial cell migration GO:0043536 9.99 VEGFA MIR210 FGF2
12 osteoblast development GO:0002076 9.93 BGLAP LRP5 RUNX2
13 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.92 RUNX2 BMP2
14 thyroid-stimulating hormone-secreting cell differentiation GO:0060129 9.91 BMP2 FGF2
15 response to vitamin D GO:0033280 9.91 BGLAP BMP7 PTH
16 ameloblast differentiation GO:0036305 9.88 BMP2 BMP7
17 mesenchyme development GO:0060485 9.88 BMP2 BMP7
18 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.87 BMP7 ESR1
19 stem cell differentiation GO:0048863 9.87 RUNX2 FGF2 ESR1 BGLAP
20 bone development GO:0060348 9.85 BGLAP BMP2 COL2A1 LRP5
21 corticotropin hormone secreting cell differentiation GO:0060128 9.8 FGF2 BMP2
22 ossification GO:0001503 9.8 RUNX2 COL2A1 BMP7 BMP2 BGLAP
23 cellular response to BMP stimulus GO:0071773 9.76 BMP2 BMP7 COL2A1 RUNX2
24 positive regulation of epithelial tube formation GO:1905278 9.71 VEGFA FGF2
25 skeletal system development GO:0001501 9.7 RUNX2 PTH COL2A1 BMP7 BMP2 BGLAP
26 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.56 MIR17 MIR210
27 negative regulation of BMP secretion GO:2001285 9.52 MIR210 MIR17
28 positive regulation of osteoblast differentiation GO:0045669 9.36 RUNX2 MIR210 LRP5 FGF2 BMP7 BMP2

Molecular functions related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.32 VEGFA FGF2 F2 BMP7 BMP2

Sources for Osteonecrosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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