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MCID: OST003
MIFTS: 67

Osteonecrosis

Categories: Blood diseases, Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Osteonecrosis

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MalaCards integrated aliases for Osteonecrosis:

Name: Osteonecrosis 39 12 77 44 45 15 17
Aseptic Necrosis 12 30
Bone Necrosis 12 74
Avascular Necrosis of Bone 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


Sources

Summaries for Osteonecrosis

About this section
MedlinePlus : 44 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down. You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well. No one is sure what causes the disease. Risk factors include Long-term steroid treatment Alcohol abuse Joint injuries Having certain diseases, including arthritis and cancer Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteonecrosis, also known as aseptic necrosis, is related to osteonecrosis of the jaw and legg-calve-perthes disease, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Osteonecrosis is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Selenium Micronutrient Network. The drugs Alendronate and Zoledronic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 An ischemic bone disease that results in necrosis located in bone.

Wikipedia : 77 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Sources

Related Diseases for Osteonecrosis

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Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis of the jaw 33.8 CYP2C8 FDPS VEGFA
2 legg-calve-perthes disease 32.6 COL2A1 SERPINC1 SERPINE1
3 myeloma, multiple 30.9 ABCB1 TNFRSF11B TNFSF11 VEGFA
4 thrombophilia 30.8 F2 MTHFR SERPINC1 SERPINE1
5 osteomyelitis 30.6 ACP5 BMP2 TNFSF11
6 disseminated intravascular coagulation 30.3 F2 SERPINC1 SERPINE1
7 antiphospholipid syndrome 30.3 F2 MTHFR SERPINC1
8 protein s deficiency 30.1 F2 MTHFR SERPINC1
9 kummell's disease 30.1 TNFRSF11B TNFSF11
10 osteoporotic fracture 30.0 MTHFR TNFRSF11B
11 thrombosis 30.0 F2 MTHFR SERPINC1 SERPINE1
12 periodontitis 30.0 BGLAP RUNX2 TNFRSF11B TNFSF11
13 villonodular synovitis 30.0 ACP5 TNFSF11
14 renal osteodystrophy 29.9 BGLAP PTH TNFRSF11B
15 antithrombin iii deficiency 29.9 F2 MTHFR SERPINC1
16 protein c deficiency 29.9 F2 MTHFR SERPINC1
17 endosteal hyperostosis, autosomal dominant 29.7 BMP2 TNFRSF11B TNFSF11
18 paget's disease of bone 29.7 BGLAP TNFRSF11B TNFSF11
19 giant cell tumor 29.7 BGLAP TNFRSF11B TNFSF11
20 heart disease 29.4 F2 MTHFR SERPINC1 SERPINE1 VEGFA
21 pseudoarthrosis 29.4 BMP2 BMP7 PTH
22 hyperparathyroidism 29.2 ACP5 BGLAP PTH TNFRSF11B
23 vascular disease 29.0 F2 MTHFR PLG SERPINC1 SERPINE1 TNFRSF11B
24 bone resorption disease 28.7 ACP5 BGLAP BMP2 PTH RUNX2 TNFRSF11B
25 osteoporosis 28.6 ACP5 BGLAP BMP2 CYP3A4 FDPS PTH
26 glucocorticoid-induced osteoporosis 28.4 ACP5 BGLAP BMP2 PTH RUNX2 TNFRSF11B
27 bone disease 28.3 ACP5 BGLAP BMP7 COL2A1 PTH RUNX2
28 dysbaric osteonecrosis 12.5
29 avascular necrosis of femoral head, primary, 1 11.8
30 familial avascular necrosis of the femoral head 11.6
31 kohler's disease 11.4
32 freiberg's disease 11.4
33 kienbock's disease 11.4
34 osgood-schlatter's disease 11.3
35 panner disease 11.3
36 sinding-larsen-johansson disease 11.3
37 thiemann disease 11.0
38 gaucher disease, type iii 11.0
39 leukemia 10.5
40 inferior vena cava interruption 10.5 MTHFR SERPINE1
41 systemic lupus erythematosus 10.5
42 lupus erythematosus 10.5
43 lymphocytic leukemia 10.4
44 neonatal stroke 10.4 MTHFR SERPINE1
45 amaurosis fugax 10.4 MTHFR SERPINE1
46 leukemia, acute lymphoblastic 10.4
47 hemifacial spasm 10.4 MTHFR VEGFA
48 breast cancer 10.4
49 mesenteric vascular occlusion 10.4 F2 MTHFR
50 sudden sensorineural hearing loss 10.4 F2 MTHFR

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to Osteonecrosis
Sources

Symptoms & Phenotypes for Osteonecrosis

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UMLS symptoms related to Osteonecrosis:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Osteonecrosis:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 ABCB1 BMP2 BMP7 COL2A1 F2 PLG
2 growth/size/body region MP:0005378 10.34 ABCB1 BMP2 BMP7 COL2A1 F2 MTHFR
3 hematopoietic system MP:0005397 10.29 ABCB1 BMP2 BMP7 F2 PLG PTH
4 immune system MP:0005387 10.29 ABCB1 BMP2 BMP7 COL2A1 F2 PLG
5 homeostasis/metabolism MP:0005376 10.27 ABCB1 BMP2 COL2A1 F2 MTHFR PLG
6 mortality/aging MP:0010768 10.21 ABCB1 BMP2 BMP7 COL2A1 F2 MTHFR
7 craniofacial MP:0005382 10.15 BMP2 BMP7 COL2A1 PTH RUNX2 TNFRSF11B
8 digestive/alimentary MP:0005381 10.14 ABCB1 BMP2 BMP7 COL2A1 F2 PLG
9 limbs/digits/tail MP:0005371 10.09 BMP2 BMP7 COL2A1 MTHFR PTH RUNX2
10 integument MP:0010771 10.06 BMP7 F2 MTHFR PLG RUNX2 SERPINE1
11 nervous system MP:0003631 10.02 ABCB1 BMP2 BMP7 COL2A1 F2 MTHFR
12 liver/biliary system MP:0005370 10.01 ABCB1 COL2A1 MTHFR PLG RUNX2 SERPINC1
13 reproductive system MP:0005389 9.96 ABCB1 BMP2 BMP7 F2 MTHFR PLG
14 respiratory system MP:0005388 9.76 BMP7 COL2A1 F2 PLG RUNX2 SERPINE1
15 skeleton MP:0005390 9.65 BMP2 BMP7 COL2A1 F2 MTHFR PTH
16 vision/eye MP:0005391 9.23 BMP7 COL2A1 MTHFR PLG RUNX2 SERPINC1
Sources

Drugs & Therapeutics for Osteonecrosis

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Drugs for Osteonecrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 267)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4,Phase 2,Phase 1 66376-36-1, 121268-17-5 2088
2
Zoledronic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118072-93-8 68740
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Propofol Approved, Investigational, Vet_approved Phase 4,Early Phase 1 2078-54-8 4943
8
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
9
Tocopherol Approved, Investigational Phase 4,Phase 3 1406-66-2 14986
10
Rivaroxaban Approved Phase 4 366789-02-8
11
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
12
Dalteparin Approved Phase 4 9005-49-6
13
Enoxaparin Approved Phase 4 9005-49-6 772
14
Methyclothiazide Approved Phase 4 135-07-9 4121
15
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
16
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
17
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
18
Mycophenolic acid Approved Phase 4 24280-93-1 446541
19
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
20
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
21
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
22
Desflurane Approved Phase 4 57041-67-5 42113
23
Acetaminophen Approved Phase 4 103-90-2 1983
24
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
25
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
26
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
27
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
28
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
29
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-02-9 14985
30
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
31
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
32 Tocotrienol Investigational Phase 4,Phase 3 6829-55-6
33 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
35 Anesthetics Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
36 Diphosphonates Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2,Not Applicable
38 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
40 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antitubercular Agents Phase 4,Not Applicable
42 Methylprednisolone Acetate Phase 4
43 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
44 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
45 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
48 Prednisolone acetate Phase 4
49 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Early Phase 1
50 Central Nervous System Depressants Phase 4,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 360)
# Name Status NCT ID Phase Drugs
1 Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis Unknown status NCT00265252 Phase 4 Alendronate
2 W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate Unknown status NCT02327949 Phase 4
3 Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases Completed NCT00434447 Phase 4 Zoledronic acid
4 Comparison of Ceramic-on-Ceramic and Ceramic-on-Highly-Cross-Linked Polyethylene Bearings Completed NCT01806766 Phase 4
5 A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients Completed NCT01345097 Phase 4
6 Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years Old Completed NCT02338596 Phase 4
7 Effectiveness of DiscontinuinG bisphosphonatEs Study: R21 Pilot Study Completed NCT02139007 Phase 4 Alendronate
8 Management of Mandibular ORN: PENTO as Medical Treatment Completed NCT02368457 Phase 4 Pentoxifylline and Tocopherol
9 Ceramic-on-Ceramic Versus Ceramic-on-HXLPE THA Completed NCT03639532 Phase 4
10 Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty Completed NCT02379663 Phase 4 Rivaroxaban;Enoxaparin
11 Benefit of Orthopedic Navigation in the ARThroplasty of the Hip Completed NCT01496300 Phase 4
12 Safety and Efficacy of Cerezyme® Infusions Every 4 Weeks Versus Every 2 Weeks in Type 1 Gaucher Disease Completed NCT00364858 Phase 4 Cerezyme
13 The 3DKneeâ„¢ System: A Post-Market Study Completed NCT00764673 Phase 4
14 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
15 A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathonâ„¢ and Enduronâ„¢ Polyethylene Cup Liners in Primary Total Hip Replacement Completed NCT00208442 Phase 4
16 Phase IV Study to Evaluate Calcineurin Inhibitor Reduced, Steroid Free Immunosuppression After Renal Transplantation Completed NCT00724022 Phase 4 Basiliximab, Tacrolimus, MMF, Prednisolon;Basiliximab, Tacrolimus, MMF;Tacrolimus, MMF, rATG
17 Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI Recruiting NCT02893293 Phase 4 Ferumoxytol-enhanced magnetic resonance imaging
18 Prolonged Protection From Bone Disease in Multiple Myeloma Recruiting NCT02286830 Phase 4 Zoledronic acid
19 Post Approval Study: NOVATION Ceramic Articulation Hip System Recruiting NCT00715143 Phase 4
20 Opioid-Free Shoulder Arthroplasty Active, not recruiting NCT03540030 Phase 4 Gabapentin;Celecoxib;toradol;acetaminophen;regional block;propofol;IV lidocaine;rocuronium;vecuronium;sevoflurane;desflurane
21 A Randomised Single Centre Study to Compare the Long-term Performance of Acrylocâ„¢ and Palacos® R Bone Cements in Primary Total Hip Replacement Terminated NCT00208403 Phase 4
22 Trilogy AB Acetabular Hip System Post Approval Study Terminated NCT00715026 Phase 4
23 Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System Terminated NCT00546598 Phase 4
24 Clinical Study Comparing Two Implant Surface Finishes in Patients Undergoing Cementless Total Hip Replacement Terminated NCT00306917 Phase 4
25 Multi-centre Study to Assess the Long-term Performance of the Deltamotion Cup System in Primary Hip Replacement Surgery Terminated NCT01635166 Phase 4
26 An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMAâ„¢ Hip in Primary Total Hip Replacement Terminated NCT01134445 Phase 4
27 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacleâ„¢ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
28 A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMAâ„¢ Hip in Primary Total Hip Replacement Terminated NCT00208455 Phase 4
29 Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem Terminated NCT01422564 Phase 4
30 A Single Centre Study to Assess the Long-term Performance of the DePuy ASRâ„¢ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
31 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stemâ„¢ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
32 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASRâ„¢ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
33 A Single Centre Study to Assess the Long-term Performance of the Pinnacleâ„¢ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
34 A Multi-centre Study to Assess the Long-term Performance of the Summitâ„¢ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
35 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASRâ„¢ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
36 A Two Centre Study to Assess the Long-term Performance of the Pinnacleâ„¢ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
37 Optetrak Posterior Stabilized Versus Optetrak Hi-Flex Withdrawn NCT00808613 Phase 4
38 A Multi-centre Study to Assess the Long-term Performance of the Pinnacleâ„¢ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
39 Implantation of Bone Marrow Cells to Treat Avascular Necrosis of Femoral Head (ANFH) Unknown status NCT01613612 Phase 2, Phase 3
40 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
41 ALL-SCT BFM International- HSCT in Children and Adolescents With ALL Unknown status NCT01423500 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
42 Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral Head Completed NCT00505219 Phase 3
43 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
44 Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
45 Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis Completed NCT00523341 Phase 3
46 Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement Completed NCT00869206 Phase 3 zoledronic acid
47 Simultaneous Study of Gemcitabine-Docetaxel Combination Adjuvant Treatment, as Well as Extended Bisphosphonate and Surveillance-Trial Completed NCT02181101 Phase 3 FEC-DocGemzar adjuvant chemotherapy;FEC-Doc adjuvant chemotherapy;Zoledronic acid i.v. 2 years;Zoledronic acid i.v. 5 years
48 Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Completed NCT01924286 Phase 3 Prednisone;Placebo
49 Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee. Completed NCT02709486 Phase 3 Tanezumab;Tanezumab;Placebo
50 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo

Search NIH Clinical Center for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC�, cultured cartilage for chondral lesion
PREOB�, autologous osteoblasts for bone disorders
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC�) PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677

Cochrane evidence based reviews: osteonecrosis

Sources

Genetic Tests for Osteonecrosis

About this section

Genetic tests related to Osteonecrosis:

# Genetic test Affiliating Genes
1 Aseptic Necrosis 30
Sources

Anatomical Context for Osteonecrosis

About this section

MalaCards organs/tissues related to Osteonecrosis:

42
Bone, Bone Marrow, Testes, Breast, Endothelial, Prostate, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Osteonecrosis:

20
Bone
Sources

Publications for Osteonecrosis

About this section

Articles related to Osteonecrosis:

(show top 50) (show all 3587)
# Title Authors Year
1
Corticosteroid dose increase is a risk factor for nonalcoholic fatty liver disease and contralateral osteonecrosis of the femoral head: a case report. ( 30782153 )
2019
2
Avascular osteonecrosis in kidney transplant recipients: Risk factors in a recent cohort study and evaluation of the role of secondary hyperparathyroidism. ( 30794689 )
2019
3
Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia: Early Diagnosis and New Treatment Strategies. ( 30842156 )
2019
4
Osteonecrosis in children with acute lymphoblastic leukemia: A report from Children's Cancer Hospital Egypt (CCHE). ( 30183135 )
2019
5
Actinomyces Orbital Osteomyelitis in the Setting of Multiple Myeloma and Bisphosphonate-Related Osteonecrosis. ( 30763286 )
2019
6
Short-term outcomes after anatomic total shoulder arthroplasty in patients with osteoarthritis versus osteonecrosis. ( 30906752 )
2019
7
Does unicompartmental knee arthroplasty have worse outcomes in spontaneous osteonecrosis of the knee than in medial compartment osteoarthritis? A systematic review and meta-analysis. ( 30680456 )
2019
8
Comparative evaluation of SPECT/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis. ( 30806799 )
2019
9
Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis. ( 30832685 )
2019
10
Core Decompression for Post-Arthroscopic Osteonecrosis of the Lateral Tibial Plateau. ( 30871297 )
2019
11
Naringin regulates bone metabolism in glucocorticoid-induced osteonecrosis of the femoral head via the Akt/Bad signal cascades. ( 30878453 )
2019
12
Treatment of osteonecrosis of the femoral head by core decompression and implantation of fully functional ex vivo-expanded bone marrow-derived mesenchymal stem cells: a proof-of-concept study. ( 30881048 )
2019
13
An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head. ( 30889646 )
2019
14
Is There a Role of Pharmacological Treatments in the Prevention or Treatment of Osteonecrosis of the Femoral Head?: A Systematic Review. ( 30899719 )
2019
15
Medication-Related Osteonecrosis of the Jaw: The Use of Leukocyte-Platelet-Rich Fibrin as an Adjunct in the Treatment. ( 30908443 )
2019
16
A 3D Printed Porous Titanium Alloy Rod with Diamond Crystal Lattice for Treatment of the Early-Stage Femoral Head Osteonecrosis in Sheep. ( 30911283 )
2019
17
Association of Traditional Chinese Medicine Therapy with Risk of Total Hip Replacement in Patients with Nontraumatic Osteonecrosis of the Femoral Head: A Population-Based Cohort Study. ( 30915147 )
2019
18
MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis. ( 30551361 )
2019
19
Drilling of bone: Effect of drill bit geometries on thermal osteonecrosis risk regions. ( 30572787 )
2019
20
Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head. ( 30587927 )
2019
21
Influence of induced infection in medication-related osteonecrosis of the jaw development after tooth extraction: A study in rats. ( 30595476 )
2019
22
Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review. ( 30595601 )
2019
23
Involvement of tumor necrosis factor alpha in steroid-associated osteonecrosis of the femoral head: friend or foe? ( 30606261 )
2019
24
Impact of IL1R1 and IL1R2 gene polymorphisms on risk of osteonecrosis of the femoral head from a case-control study. ( 30623603 )
2019
25
Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw. ( 30624969 )
2019
26
Epidemiology of osteonecrosis among older adults in Sweden. ( 30627759 )
2019
27
Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats. ( 30631095 )
2019
28
Prevalence of CAM deformity and its influence on therapy success in patients with osteonecrosis of the femoral head. ( 30636359 )
2019
29
Evaluation of medication-related osteonecrosis of the jaw using the Japanese Adverse Drug Event Report database. ( 30636879 )
2019
30
The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw. ( 30641942 )
2019
31
Is the conservative non-surgical management of medication-related osteonecrosis of the jaw an appropriate treatment option for early stages? A long-term single-center cohort study. ( 30642734 )
2019
32
Denosumab-related osteonecrosis of the jaw: a report of 2 cases and review of the literature. ( 30644830 )
2019
33
Clinical characteristics and role of whole-body bone scan in multifocal osteonecrosis. ( 30646869 )
2019
34
Surgical therapy for medication-related osteonecrosis of the jaw in osteoporotic patients treated with antiresorptive agents. ( 30647474 )
2019
35
Repair of osteonecrosis of the femoral head : 3D printed Cervi cornus Colla deproteinized bone scaffolds. ( 30656386 )
2019
36
Medication-related osteonecrosis of the jaw after long-term bisphosphonate treatment in a cat. ( 30663796 )
2019
37
Systemic comorbidities are associated with medication-related osteonecrosis of the jaws: case-control study. ( 30674072 )
2019
38
Medication-related osteonecrosis: Patients with a hidden risk of MRONJ. ( 30679851 )
2019
39
Osteonecrosis of the jaws caused by bisphosphonate treatment and oxidative stress in mice. ( 30680026 )
2019
40
Epidemiology, Cause, and Anatomy of Osteonecrosis of the Foot and Ankle. ( 30685003 )
2019
41
Core Decompression and Bone Grafting for Osteonecrosis of the Talus: A Critical Analysis of the Current Evidence. ( 30685004 )
2019
42
Vascularized Pedicle Graft for Talar Osteonecrosis. ( 30685006 )
2019
43
Association of TIMP4 gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China. ( 30697482 )
2019
44
Volume of hip synovitis detected on contrast-enhanced magnetic resonance imaging is associated with disease severity after collapse in osteonecrosis of the femoral head. ( 30697641 )
2019
45
IL-4 gene polymorphisms and their relation to steroid-induced osteonecrosis of the femoral head in Chinese population. ( 30697966 )
2019
46
The radiological and clinical follow-up of osteonecrosis in cancer patients. ( 30698062 )
2019
47
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (1), role of imaging in drug-related osteonecrosis of the jaw: An up-to-date review (secondary publication). ( 30705708 )
2019
48
Zoledronate Treatment Duration Is Linked to Bisphosphonate-Related ONJ Prevalence in Rice Rats with Generalized Periodontitis. ( 30712276 )
2019
49
Antiresorptive Agent-Related Osteonecrosis of the Jaw (ARONJ): A Twist of Fate in the Bone. ( 30713280 )
2019
50
Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw. ( 30715621 )
2019
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Variations for Osteonecrosis

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Expression for Osteonecrosis

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Search GEO for disease gene expression data for Osteonecrosis.
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Pathways for Osteonecrosis

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Pathways related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 67
Show member pathways
 12.61 BMP2 BMP7 COL2A1 PLG SERPINE1
2
Selenium Micronutrient Network 1
Show member pathways
 12.21 F2 MTHFR PLG SERPINE1
3
Formation of Fibrin Clot (Clotting Cascade) 67
Show member pathways
 12 F2 PLG SERPINC1 SERPINE1
4
Complement and coagulation cascades 38 1
11.92 F2 PLG SERPINC1 SERPINE1
5
Statin Pathway - Generalized, Pharmacokinetics 62
Show member pathways
 11.84 ABCB1 CYP2C8 CYP3A4
6
Parathyroid hormone synthesis, secretion and action 38
11.78 BGLAP PTH RUNX2 TNFSF11
7
Rheumatoid arthritis 38
11.75 ACP5 TNFSF11 VEGFA
8
Imatinib Pathway, Pharmacokinetics/Pharmacodynamics 62
Show member pathways
 11.65 ABCB1 CYP2C8 CYP3A4
9
Signaling by BMP 67
Show member pathways
 11.62 BMP2 BMP7 RUNX2
10
Paroxetine Pathway, Pharmacokinetics 62
Show member pathways
 11.59 ABCB1 CYP2C8 CYP3A4
11
HIF-1-alpha transcription factor network 1
11.54 ABCB1 SERPINE1 VEGFA
12
Phenytoin Pathway, Pharmacokinetics 62
Show member pathways
 11.52 ABCB1 CYP2C8 CYP3A4
13
Cell adhesion_ECM remodeling 23
11.49 COL2A1 PLG SERPINE1
14
Irinotecan Pathway 1
Show member pathways
 11.43 ABCB1 CYP2C8 CYP3A4
15
Endochondral Ossification 1
11.37 BMP7 COL2A1 PTH RUNX2 VEGFA
16
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11.15 BGLAP PTH RUNX2 TNFSF11
17
Erlotinib Pathway, Pharmacokinetics 62
Show member pathways
 10.99 ABCB1 CYP2C8 CYP3A4
18
Drug Induction of Bile Acid Pathway 1
10.86 ABCB1 CYP3A4
19
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 62
10.8 ABCB1 CYP3A4
20
Warfarin Pathway, Pharmacodynamics 62
10.8 BGLAP F2
21
Osteoclast Signaling 1
10.78 ACP5 TNFRSF11B TNFSF11
22
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.75 BGLAP CYP3A4 PTH RUNX2 TNFRSF11B TNFSF11
23
Dissolution of Fibrin Clot 67
10.73 PLG SERPINE1
24
Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics 62
10.72 ABCB1 CYP2C8 CYP3A4
25
Taxane Pathway, Pharmacokinetics 62
10.61 ABCB1 CYP2C8 CYP3A4
26
Vinka Alkaloid Pathway, Pharmacokinetics 62
10.6 ABCB1 CYP3A4
27
Osteoblast Signaling 1
10.4 BGLAP PTH TNFRSF11B TNFSF11
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GO Terms for Osteonecrosis

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Cellular components related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BGLAP BMP2 BMP7 COL2A1 F2 PLG
2 endoplasmic reticulum lumen GO:0005788 9.62 BGLAP COL2A1 F2 SERPINC1
3 collagen-containing extracellular matrix GO:0062023 9.55 BMP7 COL2A1 PLG SERPINC1 SERPINE1
4 platelet alpha granule lumen GO:0031093 9.43 PLG SERPINE1 VEGFA
5 extracellular space GO:0005615 9.4 BGLAP BMP2 BMP7 COL2A1 F2 PLG

Biological processes related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 ABCB1 BGLAP MTHFR PTH TNFRSF11B
2 osteoblast differentiation GO:0001649 9.84 BGLAP BMP2 RUNX2
3 BMP signaling pathway GO:0030509 9.81 BMP2 BMP7 RUNX2
4 cartilage development GO:0051216 9.8 BMP2 BMP7 COL2A1
5 positive regulation of osteoblast differentiation GO:0045669 9.77 BMP2 BMP7 RUNX2
6 odontogenesis of dentin-containing tooth GO:0042475 9.76 BMP2 BMP7 RUNX2
7 regulation of signaling receptor activity GO:0010469 9.76 BMP2 BMP7 F2 PTH SERPINE1 TNFRSF11B
8 bone development GO:0060348 9.72 BGLAP COL2A1 TNFSF11
9 hemostasis GO:0007599 9.71 F2 PLG SERPINC1
10 bone mineralization GO:0030282 9.69 BGLAP BMP2 PTH
11 mammary gland alveolus development GO:0060749 9.67 TNFSF11 VEGFA
12 chondrocyte differentiation GO:0002062 9.67 BMP2 COL2A1 RUNX2
13 regulation of osteoclast differentiation GO:0045670 9.66 BGLAP TNFSF11
14 positive regulation of ossification GO:0045778 9.65 BMP2 PTH
15 positive regulation of blood coagulation GO:0030194 9.65 F2 SERPINE1
16 regulation of blood coagulation GO:0030193 9.65 F2 SERPINC1
17 response to inorganic substance GO:0010035 9.64 BGLAP TNFRSF11B
18 embryonic skeletal joint morphogenesis GO:0060272 9.63 BMP7 COL2A1
19 mesenchymal cell differentiation GO:0048762 9.63 BMP2 BMP7
20 positive regulation of bone mineralization GO:0030501 9.63 BMP2 BMP7 PTH
21 oxidative demethylation GO:0070989 9.62 CYP2C8 CYP3A4
22 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.61 BMP2 RUNX2
23 proteoglycan metabolic process GO:0006029 9.61 BMP2 COL2A1
24 bone resorption GO:0045453 9.61 ACP5 PTH TNFSF11
25 fibrinolysis GO:0042730 9.58 F2 PLG SERPINE1
26 lipid hydroxylation GO:0002933 9.57 CYP2C8 CYP3A4
27 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.56 BMP2 RUNX2
28 cellular response to BMP stimulus GO:0071773 9.56 BMP2 BMP7 COL2A1 RUNX2
29 response to vitamin D GO:0033280 9.54 BGLAP BMP7 PTH
30 mesenchyme development GO:0060485 9.52 BMP2 BMP7
31 negative regulation of fibrinolysis GO:0051918 9.5 F2 PLG SERPINE1
32 skeletal system development GO:0001501 9.5 BGLAP BMP2 BMP7 COL2A1 PTH RUNX2
33 ossification GO:0001503 9.17 ACP5 BGLAP BMP2 BMP7 COL2A1 RUNX2
34 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 BMP2 BMP7 PTH RUNX2 SERPINE1 TNFSF11
35 positive regulation of gene expression GO:0010628 10 BMP2 BMP7 RUNX2 TNFSF11 VEGFA

Molecular functions related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 BMP2 BMP7 F2 VEGFA
2 heparin binding GO:0008201 9.46 BMP7 F2 SERPINC1 VEGFA
3 BMP receptor binding GO:0070700 9.37 BMP2 BMP7
4 estrogen 16-alpha-hydroxylase activity GO:0101020 9.32 CYP2C8 CYP3A4
5 cytokine activity GO:0005125 9.02 BMP2 BMP7 TNFRSF11B TNFSF11 VEGFA
6 caffeine oxidase activity GO:0034875 8.96 CYP2C8 CYP3A4
Sources

Sources for Osteonecrosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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