Categories: Blood diseases, Bone diseases, Rare diseases

Aliases & Classifications for Osteonecrosis

MalaCards integrated aliases for Osteonecrosis:

Name: Osteonecrosis 12 74 58 42 43 15 37 17 32
Bone Necrosis 12 58 71
Aseptic Necrosis 12 29
Avascular Necrosis of Bone 12


Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases

External Ids:

Disease Ontology 12 DOID:10159
MeSH 43 D010020
ICD10 via Orphanet 33 M87.0 M87.1 M87.2 more
UMLS via Orphanet 72 C0029445
Orphanet 58 ORPHA399158
UMLS 71 C0003977 C0027543 C0029445 more

Summaries for Osteonecrosis

MedlinePlus : 42 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down. You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well. No one is sure what causes the disease. Risk factors include Long-term steroid treatment Alcohol misuse Joint injuries Having certain diseases, including arthritis and cancer Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteonecrosis, also known as bone necrosis, is related to osteonecrosis of the jaw and avascular necrosis, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Osteonecrosis is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Folate Metabolism and Wnt / Hedgehog / Notch. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related phenotypes are growth/size/body region and cardiovascular system

Disease Ontology : 12 An ischemic bone disease that results in necrosis located in bone.

Wikipedia : 74 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Osteonecrosis

Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 715)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis of the jaw 34.4 VEGFA NFATC1 FDPS CYP2C8
2 avascular necrosis 33.7 COL2A1 BMP2 ABCB1
3 thrombophilia due to thrombin defect 31.3 SERPINE1 MTHFR F2
4 childhood acute lymphocytic leukemia 31.1 VEGFA MTHFR ABCB1
5 osteomyelitis 31.1 TNFSF11 TNF NFATC1 BMP2 ACP5
6 exostosis 31.0 COL2A1 BMP2 BGLAP
7 sickle cell anemia 31.0 TNF MTHFR F2
8 protein s deficiency 30.9 SERPINE1 MTHFR F2
9 antiphospholipid syndrome 30.9 TNF SERPINE1 MTHFR F2
10 protein c deficiency 30.9 SERPINE1 MTHFR F2
11 osteochondritis dissecans 30.9 COL2A1 BMP7 BMP2
12 mucositis 30.8 VEGFA MTHFR ABCB1
13 thrombophilia due to activated protein c resistance 30.8 SERPINE1 MTHFR F2
14 disseminated intravascular coagulation 30.8 TNF SERPINE1 F2
15 gaucher's disease 30.8 TNF BGLAP ACP5
16 arthropathy 30.8 TNFSF11 TNFRSF11B TNF COL2A1
17 osteoarthritis 30.6 TNFSF11 TNFRSF11B TNF RUNX2 COL2A1 BMP2
18 osteomalacia 30.6 TNFSF11 PTH BGLAP
19 bone cancer 30.5 TNFSF11 TNFRSF11B PTH BMP2
20 inflammatory bowel disease 30.5 VEGFA TNF NFATC1 MTHFR F2 BGLAP
21 villonodular synovitis 30.5 TNFSF11 ACP5
22 bone inflammation disease 30.5 VEGFA TNFSF11 TNFRSF11B TNF COL2A1
23 exanthem 30.5 VEGFA TNF F2
24 mammary paget's disease 30.5 TNFSF11 TNFRSF11B PTH FDPS BGLAP ACP5
25 thrombophlebitis 30.4 TNF SERPINE1 MTHFR F2
26 homocysteinemia 30.4 SERPINE1 MTHFR F2
27 sudden sensorineural hearing loss 30.4 MTHFR F2
28 endosteal hyperostosis, autosomal dominant 30.4 TNFSF11 TNFRSF11B NFATC1 LRP5 BMP2 ACP5
29 leukostasis 30.4 VEGFA TNF NFATC1
30 fibrous dysplasia 30.4 TNFSF11 TNFRSF11B RUNX2 BGLAP
31 synovitis 30.4 VEGFA TNFSF11 TNFRSF11B TNF COL2A1 ACP5
32 pigmented villonodular synovitis 30.3 TNFSF11 TNFRSF11B ACP5
33 kummell's disease 30.3 TNFSF11 TNFRSF11B DKK1
34 catastrophic antiphospholipid syndrome 30.3 SERPINE1 MTHFR
35 spondylitis 30.3 TNFSF11 TNF DKK1
36 pulmonary embolism 30.3 SERPINE1 MTHFR F2
37 hellp syndrome 30.2 VEGFA SERPINE1 MTHFR F2
38 periodontitis 30.2 VEGFA TNFSF11 TNFRSF11B TNF RUNX2 BGLAP
39 peripheral vascular disease 30.2 VEGFA SERPINE1 MTHFR F2
40 periodontitis, chronic 30.2 TNFSF11 TNFRSF11B
41 vascular disease 30.2 VEGFA TNFRSF11B TNF SERPINE1 PTH MTHFR
42 placenta disease 30.2 VEGFA TNF MTHFR F2
43 dental pulp necrosis 30.2 TNFSF11 BMP2 BGLAP
44 hypothyroidism 30.1 VEGFA TNFRSF11B TNF SERPINE1 F2 BGLAP
45 eclampsia 30.1 VEGFA TNF SERPINE1 MTHFR F2
46 periapical periodontitis 30.1 TNFSF11 TNFRSF11B TNF ACP5
47 hyperparathyroidism 30.0 TNFSF11 TNFRSF11B PTH BGLAP ACP5
48 poems syndrome 30.0 VEGFA TNFSF11 TNFRSF11B TNF
49 paget's disease of bone 30.0 TNFSF11 TNFRSF11B PTH DKK1 BGLAP ACP5
50 gorham's disease 30.0 VEGFA TNFSF11 PTH

Graphical network of the top 20 diseases related to Osteonecrosis:

Diseases related to Osteonecrosis

Symptoms & Phenotypes for Osteonecrosis

UMLS symptoms related to Osteonecrosis:

back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Osteonecrosis:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.43 ABCB1 BMP2 BMP7 COL2A1 DKK1 F2
2 cardiovascular system MP:0005385 10.4 ABCB1 BMP2 BMP7 COL2A1 F2 LRP5
3 hematopoietic system MP:0005397 10.36 ABCB1 BGLAP BMP2 BMP7 F2 LRP5
4 cellular MP:0005384 10.35 BGLAP BMP2 COL2A1 DKK1 F2 LRP5
5 craniofacial MP:0005382 10.35 BMP2 BMP7 COL2A1 DKK1 LRP5 NFATC1
6 immune system MP:0005387 10.35 ABCB1 BGLAP BMP2 BMP7 COL2A1 F2
7 homeostasis/metabolism MP:0005376 10.34 ABCB1 BGLAP BMP2 COL2A1 DKK1 F2
8 mortality/aging MP:0010768 10.27 ABCB1 BMP2 BMP7 COL2A1 DKK1 F2
9 limbs/digits/tail MP:0005371 10.25 BMP2 BMP7 COL2A1 DKK1 LRP5 MTHFR
10 digestive/alimentary MP:0005381 10.21 ABCB1 BMP2 BMP7 COL2A1 F2 NFATC1
11 embryo MP:0005380 10.2 BMP2 BMP7 COL2A1 DKK1 F2 LRP5
12 endocrine/exocrine gland MP:0005379 10.19 ABCB1 BGLAP BMP7 LRP5 PTH RUNX2
13 integument MP:0010771 10.11 BMP7 F2 MTHFR NFATC1 RUNX2 SERPINE1
14 liver/biliary system MP:0005370 10.06 ABCB1 COL2A1 LRP5 MTHFR NFATC1 RUNX2
15 nervous system MP:0003631 10.06 ABCB1 BMP2 BMP7 COL2A1 DKK1 F2
16 reproductive system MP:0005389 9.96 ABCB1 BGLAP BMP2 BMP7 F2 MTHFR
17 respiratory system MP:0005388 9.85 BMP7 COL2A1 DKK1 F2 NFATC1 RUNX2
18 skeleton MP:0005390 9.83 BGLAP BMP2 BMP7 COL2A1 DKK1 F2
19 vision/eye MP:0005391 9.32 BMP7 COL2A1 DKK1 LRP5 MTHFR PTH

Drugs & Therapeutics for Osteonecrosis

Drugs for Osteonecrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 223)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Zoledronic Acid Approved Phase 4 118072-93-8 68740
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Neuroprotective Agents Phase 4
9 Methylprednisolone Acetate Phase 4
10 Parenteral Nutrition Solutions Phase 4
11 Ferrosoferric Oxide Phase 4
12 Immunologic Factors Phase 4
13 Viscosupplements Phase 4
14 Adjuvants, Immunologic Phase 4
Tranexamic Acid Approved Phase 3 1197-18-8 5526
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
Calcium carbonate Approved, Investigational Phase 3 471-34-1
Denosumab Approved Phase 3 615258-40-7
Alendronate Approved Phase 2, Phase 3 66376-36-1, 121268-17-5 2088
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
rituximab Approved Phase 3 174722-31-7 10201696
inotuzumab ozogamicin Approved, Investigational Phase 3 635715-01-4
Allopurinol Approved Phase 3 315-30-0 2094
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
Pegaspargase Approved, Investigational Phase 3 130167-69-0
leucovorin Approved Phase 3 58-05-9 6006 143
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
Daunorubicin Approved Phase 3 20830-81-3 30323
Mercaptopurine Approved Phase 3 50-44-2 667490
Thioguanine Approved Phase 3 154-42-7 2723601
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
Etoposide Approved Phase 3 33419-42-0 36462
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
Ichthammol Approved Phase 3 8029-68-3
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3 67-97-0 5280795 6221
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
Calcitriol Approved, Nutraceutical Phase 2, Phase 3 32222-06-3 5280453 134070

Interventional clinical trials:

(show top 50) (show all 215)
# Name Status NCT ID Phase Drugs
1 Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis Unknown status NCT00265252 Phase 4 Alendronate
2 Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery Unknown status NCT03190642 Phase 4 Methylprednisolone
3 A Phase IV, Multi-center, Open Label, Single Arm Clinical Trial to Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
4 Randomized, Prospective, Multi-center, Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
5 A Phase IV Study of Zoledronic Acid Therapy in Patients With Bone Metastases From Breast Cancer or Hormone Resistant Prostate Cancer, or Bone Involvement From Multiple Myeloma, Assessing Long-term Efficacy and Safety Completed NCT00434447 Phase 4 Zoledronic acid
6 Comparison of Ceramic-on-Ceramic and Ceramic-on-Highly-Cross-Linked Polyethylene Bearings in Primary Cementless Total Hip Arthroplasty in the Same Patients Completed NCT01806766 Phase 4
7 A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients Completed NCT01345097 Phase 4
8 Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment Completed NCT02368457 Phase 4 Pentoxifylline and Tocopherol
9 Comparison of the Outcomes of Ultra-Short Anatomic and Conventional Cementless Stems in Patients Younger Than Fifty-Five Years Old Completed NCT02338596 Phase 4
10 Efficacy of Lower Dose Prednisolone in the Induction of Remission of Lupus Nephritis Completed NCT04146220 Phase 4 Prednisolone
11 Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI Recruiting NCT02893293 Phase 4 Ferumoxytol-enhanced magnetic resonance imaging
12 Magnolia Study Prolonged Protection From Bone Disease in Multiple Myeloma. An Open Label Phase 3 Multicenter International Randomised Trial Recruiting NCT02286830 Phase 4 Zoledronic acid
13 The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) Versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: a Randomized, Double-blind Control Trial Active, not recruiting NCT02984228 Phase 4 Hyaluronic Acid
14 A Prospective, Single-center, Non-randomized, Consecutive Series Clinical Study Comparing the Functional Differences Between a Standard Posterior Stabilized Total Knee Replacement and a High-flexion Posterior Stabilized Total Knee Replacement Withdrawn NCT00808613 Phase 4
15 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Unknown status NCT01892514 Phase 3
16 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
17 Use of Tranexamic Acid(TNA) in Preventing Blood Loss During and After Total Hip Arthroplasty Unknown status NCT02587845 Phase 3 Tranexamic Acid (IV);Tranexamic Acid (Topical)
18 Zoledronate Versus Ibandronate Comparative Evaluation: A Randomized Phase III, Open-Label, Multicenter, Parallel Group Clinical Trial to Evaluate and Compare the Efficacy, Safety Profile and Tolerability of Oral Ibandronate Versus Intravenous Zoledronate in the Treatment of Breast Cancer Patients With Bone Metastases Unknown status NCT00326820 Phase 3 ibandronate sodium;zoledronic acid;Zolendronic Acid
19 Metabolic, Endocrine, and Central Effects of Genistein Aglycone in Glucocorticoid Induced Osteoporosis Unknown status NCT03040531 Phase 2, Phase 3 Alendronate Oral Tablet
20 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
21 Multi-center Clinical Trial of the Application of Ixmyelocel-T in the Treatment of Osteonecrosis of the Femoral Head Completed NCT00505219 Phase 3
22 Multicenter, Open-labeled, Randomized Clinical Trial to Determine the Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
23 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
24 A Randomized, Phase III Study of Standard Dosing Versus Longer Dosing Interval of Zoledronic Acid in Metastatic Cancer Completed NCT00869206 Phase 3 zoledronic acid
25 Preventing Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Completed NCT01924286 Phase 3 Prednisone;Placebo
26 Effect of Zoledronic Acid on Chemotherapy Induced Bone Loss in Non-Hodgkin's Lymphoma Patients Receiving Chemotherapy Completed NCT00352846 Phase 3 Zoledronic Acid;Vitamin D;Calcium Carbonate
27 Aspirin (Acetylsalicylic Acid) in the Prevention of Collapse of the Femoral Head in Early-stage Non-traumatic Osteonecrosis: a Two-year Multicenter, Prospective, Randomized, Double-blind, Placebo-controlled Study Recruiting NCT03405974 Phase 3 Aspirin;Placebo
28 Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks - A Non-Inferiority Phase III Trial Recruiting NCT02051218 Phase 3 Denosumab (reduced dosing);Denosumab (standard dosing)
29 A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL Recruiting NCT03150693 Phase 3 Allopurinol;Cytarabine;Daunorubicin Hydrochloride;Vincristine Sulfate;Dexamethasone;Pegylated L-Asparaginase;Methotrexate;Cyclophosphamide;Mercaptopurine;Doxorubicin;Thioguanine
30 Evaluation of the Efficacy and Tolerability of Alendronate Versus Denosumab in Kidney Transplant Patients With Reduced Bone Mineral Density Recruiting NCT04169698 Phase 2, Phase 3 Denosumab 60 mg/ml [Prolia];Alendronate 70Mg Tab
31 A Randomized Placebo Controlled Trial Testing The Effect of Zoledronic Acid on Hip Osteoarthritis Recruiting NCT04303026 Phase 3 Zoledronic Acid;Saline 0.9%
32 A Phase III Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia (B-ALL) Including a Stratum Evaluating Dasatinib (NSC#732517) in Patients With Ph-Like Tyrosine Kinase Inhibitor (TKI) Sensitive Mutations Active, not recruiting NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
33 Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment Enrolling by invitation NCT03040778 Phase 3 Pentoxifylline;Placebo;Tocopherol
34 Plasma Rich in Growth Factors for Treatment of Medication Related Osteonecrosis of the Jaw: a Multicenter, Randomized, Clinical Trial Not yet recruiting NCT03390777 Phase 2, Phase 3
35 Phase 3, Pivotal, Multicentre, Randomised, Double-blind Controlled Study to Evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Osteonecrosis of the Femoral Head Terminated NCT01529008 Phase 3 Core decompression/PREOB® implantation;Core decompression/placebo implantation
36 Double Blind Randomized Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis Stage 1 and 2 Terminated NCT02114489 Phase 3 ibandronate;Placebo
37 Efficacy and Safety of Etoricoxib in Acute Soft Tissue Rheumatism Affecting the Shoulder Terminated NCT00876317 Phase 3 Etoricoxib 60 mg;Etoricoxib 90 mg
38 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Unknown status NCT02448121 Phase 1, Phase 2
39 Evaluation of Safety and Performance of Macroporous Biphasic Calcium Phosphate Granules Combined With Cellulosic-Derived Gel, in Filling Bones Gap After Aseptic Osteonecrosis Biopsy of Femur Head. Unknown status NCT00289575 Phase 2
40 The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSC) Unknown status NCT03180463 Phase 1, Phase 2 Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#)
41 A Randomised Controlled Trial of Bisphosphonate Therapy in Osteonecrosis of the Hip Unknown status NCT00781261 Phase 2 Zoledronic Acid;Placebo
42 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Unknown status NCT02065167 Phase 2
43 Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study Unknown status NCT00760682 Phase 2
44 PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells Completed NCT01700920 Phase 2
45 Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD- A Phase I/II Clinical Trial Completed NCT02824653 Phase 1, Phase 2
46 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Completed NCT01605383 Phase 1, Phase 2
47 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
48 Effect of Hydroxyurea on Fetal Hemoglobin Synthesis in Patients With Sickle Cell Anemia Completed NCT00001197 Phase 2 Hydroxyurea
49 A Randomized Controlled Trial of Core Decompression With or Without Cement Packing for Osteonecrosis of the Femoral Head - Long Term Results Completed NCT04233125 Phase 1, Phase 2
50 Effect of Cycle Ergometer in the Rehabilitation of Elderly Patients With Total Hip Arthroplasty: Randomized Controlled Trial Completed NCT01622465 Phase 2

Search NIH Clinical Center for Osteonecrosis

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC, cultured cartilage for chondral lesion
PREOB, autologous osteoblasts for bone disorders
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC) PMIDs: 19393556 10738867 16226641 12043781 16233853 19802670 10679677 11284883 16233778

Cochrane evidence based reviews: osteonecrosis

Genetic Tests for Osteonecrosis

Genetic tests related to Osteonecrosis:

# Genetic test Affiliating Genes
1 Aseptic Necrosis 29

Anatomical Context for Osteonecrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteonecrosis:


MalaCards organs/tissues related to Osteonecrosis:

Bone, Bone Marrow, Breast, Testes, Endothelial, Prostate, Kidney

Publications for Osteonecrosis

Articles related to Osteonecrosis:

(show top 50) (show all 11006)
# Title Authors PMID Year
Bisphosphonate-related osteonecrosis of the jaw: Current clinical significance and treatment strategy review. 61 42
32470236 2020
Efficacy of total hip arthroplasty for the treatment of patients with femoral head avascular necrosis: A protocol for systematic review and meta-analysis. 42
32443366 2020
Efficacy of extracorporeal shock wave combined spinal core decompression for the treatment of patients with femoral head necrosis: A protocol for systematic review and meta-analysis. 42
32481326 2020
Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis. 61
32405574 2020
Agrimonia pilosa polysaccharide and its sulfate derives facilitate cell proliferation and osteogenic differentiation of MC3T3-E1 cells by targeting miR-107. 61
31786295 2020
Whole-joint magnetic resonance imaging to assess osteonecrosis in pediatric patients with acute lymphoblastic lymphoma. 61
32472969 2020
Pinocembrin alleviates glucocorticoid-induced apoptosis by activating autophagy via suppressing the PI3K/Akt/mTOR pathway in osteocytes. 61
32470335 2020
Primary total hip replacement in Ficat-Arlet stage 3 and 4 osteonecrosis: a retrospective study at a minimum 12-year follow-up. 61
32107641 2020
Alveolar bone histological necrosis observed prior to extractions in patients, who received bone-targeting agents. 61
32011077 2020
The feasibility of locating the affected bone of BRONJ with indocyanine green. 61
32031311 2020
Surgical hip dislocation with femoral osteotomy and bone grafting prevents head collapse in hips with advanced necrosis. 61
31204506 2020
Suboptimal outcomes after internal fixation for displaced intracapsular femoral neck fractures in 50- to 60-year-old patients. 61
31232109 2020
Twelve-month outcome in juvenile proliferative lupus nephritis: results of the German registry study. 61
32193650 2020
Nicotinamide mononucleotide attenuates glucocorticoid‑induced osteogenic inhibition by regulating the SIRT1/PGC‑1α signaling pathway. 61
32377728 2020
New therapeutic opportunities for COVID-19 patients with Tocilizumab: Possible correlation of interleukin-6 receptor inhibitors with osteonecrosis of the jaws. 61
32209313 2020
Valgus Correctability and Meniscal Extrusion Were Associated With Alignment After Unicompartmental Knee Arthroplasty. 61
32324667 2020
Intra-articular pathology affects outcomes after joint preserving surgery for osteonecrosis of the femoral head. 61
32246165 2020
Treatment of avascular osteonecrosis of femoral head by core decompression and platelet-rich plasma: a prospective not controlled study. 61
32483678 2020
Efficacy of bone marrow stem cells combined with core decompression in the treatment of osteonecrosis of the femoral head: A PRISMA-compliant meta-analysis. 61
32569171 2020
Incidence of and risk factors for medication-related osteonecrosis of the jaw in women with breast cancer with bone metastasis: a population-based study. 61
32536575 2020
CORR Insights®: Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized Controlled Trial. 61
32118607 2020
A 3D printed porous titanium alloy rod with biogenic lamellar configuration for treatment of the early-stage femoral head osteonecrosis in sheep. 61
32250947 2020
Digital Subtraction Angiography and Magnetic Resonance Imaging-Based Staging of Circulatory Obstruction in the Femoral Head During Osteonecrosis of the Femoral Head Development. 61
32501844 2020
Core Decompression Combined with Implantation of Autologous Bone Marrow Concentrate with Tricalcium Phosphate Does Not Prevent Radiographic Progression in Early Stage Osteonecrosis of the Hip. 61
32489535 2020
Quantitative evaluation of anti-resorptive agent-related osteonecrosis of the jaw using bone single photon emission computed tomography in clinical settings: relationship between clinical stage and imaging. 61
32557015 2020
Comment on "The Effect of Platelet-Rich Fibrin Membrane in Surgical Therapy of Medication-Related Osteonecrosis of the Jaw" by Szentpeteri et al. 61
32504560 2020
Is bone marrow edema syndrome a precursor of hip or knee osteonecrosis? Results of 49 patients and review of the literature. 61
32558648 2020
Association Between Genetic Polymorphisms of CR2 Gene and the Risk of Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Han Male Population. 61
32552036 2020
Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice. 61
32142911 2020
Fibula allograft propping as an effective treatment for early-stage osteonecrosis of the femoral head: a systematic review. 61
32493388 2020
Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized, Controlled Trial. 61
31899739 2020
Curved Intertrochanteric Varus Osteotomy vs Total Hip Arthroplasty for Osteonecrosis of the Femoral Head in Patients Under 50 Years Old. 61
32063410 2020
Role of Local Flaps to Achieve Primary Wound Closure in Medication-Related Osteonecrosis of the Jaws Osseous-Resective Surgery. 61
32149968 2020
Influence of ridge preservation procedures on extraction socket healing under antiresorptive therapy: An experimental study in rabbits. 61
32537909 2020
Long-term impact of bone-modifying agents for the treatment of bone metastases: a systematic review. 61
32535678 2020
Replacing one evil with another: Is the fibula really a dispensable spare part available for transfer in patients with medication-related osteonecrosis of the jaws? 61
32102764 2020
High incidence of "in-out-in" posterosuperior screws after cannulated screw fixation of femoral neck fractures. 61
32556582 2020
Influence of bone density, drill diameter, drilling speed, and irrigation on temperature changes during implant osteotomies: an in vitro study. 61
32533265 2020
miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis. 61
32395770 2020
Comprehensive analysis on orthopedic drilling: A state-of-the-art review. 61
32186229 2020
Management of bone metastasis with intravenous bisphosphonates in breast cancer: a systematic review and meta-analysis of dosing frequency. 61
32060705 2020
Zoledronate Inhibits Osteoclast Differentiation via Suppressing Vascular Endothelial Growth Factor Receptor 2 Expression. 61
32274606 2020
Evaluation and Management of Carpal Fractures Other Than the Scaphoid. 61
32501853 2020
Assessment of inflammatory jaw pathologies using bone SPECT/CT maximum standardized uptake value. 61
32491931 2020
Uveitis Therapy: The Corticosteroid Options. 61
32350761 2020
Bisphosphonate-Induced Osteonecrosis of the Jaws (BIONJ). 61
32346224 2020
A Novel Disorder of Osteoporosis, Osteonecrosis, and Metaphyseal Fracture. 61
32537551 2020
Development of a novel minimally invasive technique to washout necrotic bone marrow content from epiphyseal bone: A preliminary cadaveric bone study. 61
32146150 2020
Osteonecrosis and Multifocal Bone Infarction in Systemic Lupus Erythematosus. 61
32453296 2020
Computed tomography imaging features of osteomyelitis of the jaw: comparison between antiresorptive medication-related conditions and medication-unrelated conditions. 61
31983632 2020

Variations for Osteonecrosis

Expression for Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for Osteonecrosis

Pathways related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
Show member pathways
6 11.74 TNF BMP7 BMP2
Show member pathways
Show member pathways
11.6 RUNX2 BMP7 BMP2
14 11.37 VEGFA TNFSF11 DKK1
15 11.33 VEGFA NFATC1 BMP2
17 10.9 TNFSF11 TNF COL2A1 BMP7 BMP2
18 10.84 TNFSF11 TNFRSF11B ACP5
20 10.7 DKK1 BMP2

GO Terms for Osteonecrosis

Cellular components related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFA TNFSF11 TNFRSF11B TNF SERPINE1 PTH
2 extracellular space GO:0005615 9.4 VEGFA TNFSF11 TNFRSF11B TNF SERPINE1 PTH

Biological processes related to Osteonecrosis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.11 VEGFA TNFSF11 TNF LRP5 F2 DKK1
2 positive regulation of transcription, DNA-templated GO:0045893 10.04 TNF RUNX2 NFATC1 LRP5 BMP7 BMP2
3 extracellular matrix organization GO:0030198 9.96 TNFRSF11B TNF SERPINE1 COL2A1
4 response to drug GO:0042493 9.92 TNFRSF11B PTH MTHFR BGLAP ABCB1
5 positive regulation of protein phosphorylation GO:0001934 9.89 VEGFA TNF F2 BMP2
6 positive regulation of gene expression GO:0010628 9.87 VEGFA TNFSF11 TNF RUNX2 DKK1 BMP7
7 animal organ morphogenesis GO:0009887 9.85 TNFSF11 TNF BMP7 BMP2
8 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 VEGFA TNFSF11 TNF SERPINE1 RUNX2 PTH
9 BMP signaling pathway GO:0030509 9.83 RUNX2 BMP7 BMP2
10 cartilage development GO:0051216 9.82 COL2A1 BMP7 BMP2
11 positive regulation of MAP kinase activity GO:0043406 9.78 VEGFA TNFSF11 TNF
12 odontogenesis of dentin-containing tooth GO:0042475 9.76 RUNX2 BMP7 BMP2
13 chondrocyte differentiation GO:0002062 9.73 RUNX2 COL2A1 BMP2
14 positive regulation of bone mineralization GO:0030501 9.71 PTH BMP7 BMP2
15 positive regulation of osteoblast differentiation GO:0045669 9.71 RUNX2 LRP5 BMP7 BMP2
16 bone resorption GO:0045453 9.67 TNFSF11 PTH ACP5
17 bone development GO:0060348 9.67 TNFSF11 LRP5 COL2A1 BGLAP
18 positive regulation of osteoblast proliferation GO:0033690 9.65 LRP5 BMP2
19 osteoblast development GO:0002076 9.65 RUNX2 LRP5 BGLAP
20 embryonic skeletal joint morphogenesis GO:0060272 9.64 COL2A1 BMP7
21 negative regulation of fibrinolysis GO:0051918 9.64 SERPINE1 F2
22 mesenchymal cell differentiation GO:0048762 9.63 BMP7 BMP2
23 negative regulation of cardiac muscle cell differentiation GO:2000726 9.63 DKK1 BMP2
24 response to vitamin D GO:0033280 9.63 PTH BMP7 BGLAP
25 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.62 RUNX2 BMP2
26 negative regulation of vascular wound healing GO:0061044 9.62 TNF SERPINE1
27 proteoglycan metabolic process GO:0006029 9.61 COL2A1 BMP2
28 regulation of osteoclast differentiation GO:0045670 9.61 TNFSF11 TNF BGLAP
29 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.6 RUNX2 BMP2
30 mesenchyme development GO:0060485 9.58 BMP7 BMP2
31 cellular response to BMP stimulus GO:0071773 9.56 RUNX2 COL2A1 BMP7 BMP2
32 skeletal system development GO:0001501 9.5 TNFRSF11B RUNX2 PTH COL2A1 BMP7 BMP2
33 ossification GO:0001503 9.17 TNFSF11 RUNX2 COL2A1 BMP7 BMP2 BGLAP

Molecular functions related to Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 VEGFA F2 DKK1 BMP7 BMP2
2 BMP receptor binding GO:0070700 9.26 BMP7 BMP2
3 co-receptor binding GO:0039706 9.16 DKK1 BMP2
4 cytokine activity GO:0005125 9.1 VEGFA TNFSF11 TNFRSF11B TNF BMP7 BMP2

Sources for Osteonecrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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