MCID: OST115
MIFTS: 38

Osteonecrosis of the Jaw

Categories: Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Osteonecrosis of the Jaw

MalaCards integrated aliases for Osteonecrosis of the Jaw:

Name: Osteonecrosis of the Jaw 60

Classifications:



External Ids:

ICD10 via Orphanet 35 K10.2
UMLS via Orphanet 75 C2711248
Orphanet 60 ORPHA399293

Summaries for Osteonecrosis of the Jaw

MalaCards based summary : Osteonecrosis of the Jaw is related to osteonecrosis and periodontal disease. An important gene associated with Osteonecrosis of the Jaw is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include bone, prostate and t cells, and related phenotype is renal/urinary system.

Wikipedia : 77 Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the... more...

Related Diseases for Osteonecrosis of the Jaw

Diseases related to Osteonecrosis of the Jaw via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 32.6 CYP2C8 FDPS VEGFA
2 periodontal disease 30.6 DEFB1 DEFB4A IL17A
3 arthritis 30.3 HLA-DQB1 HLA-DRB1 IL17A TGFB1
4 rheumatoid arthritis 30.1 HLA-DQB1 HLA-DRB1 IL17A TGFB1 VEGFA
5 myeloma, multiple 10.8
6 osteoporosis 10.8
7 breast cancer 10.7
8 prostate cancer 10.6
9 prostate cancer, hereditary, 8 10.6
10 prostate cancer, hereditary, 6 10.6
11 bone mineral density quantitative trait locus 8 10.5
12 bone mineral density quantitative trait locus 15 10.5
13 osteomyelitis 10.5
14 cerebrotendinous xanthomatosis 10.4
15 periodontitis 10.3
16 central nervous system vasculitis 10.3 HLA-DRB1 IL17A
17 chronic inflammatory demyelinating polyradiculoneuropathy 10.3 HLA-DRB1 IL17A
18 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
19 rapidly involuting congenital hemangioma 10.3
20 cystic echinococcosis 10.3 HLA-DRB1 IL17A
21 endophthalmitis 10.3 DEFB1 VEGFA
22 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
23 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
24 hypersomnia 10.3 HLA-DQB1 HLA-DRB1
25 corneal abscess 10.2 DEFB1 DEFB4A
26 metal allergy 10.2 HLA-DQB1 HLA-DRB1
27 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
28 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
29 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
30 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
31 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
32 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
33 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
34 bone disease 10.2
35 bone resorption disease 10.2
36 thrombophilia 10.2
37 whipple disease 10.2 HLA-DQB1 HLA-DRB1
38 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
39 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
40 microscopic colitis 10.2 HLA-DQB1 HLA-DRB1
41 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
42 diabetes mellitus 10.2
43 herpes zoster 10.2
44 fasciitis 10.2
45 necrotizing fasciitis 10.2
46 bowenoid papulosis 10.2
47 juvenile myasthenia gravis 10.2 HLA-DRB1 TGFB1
48 intestinal disease 10.2 DEFB4A IL17A VEGFA
49 vulvovaginal candidiasis 10.2 DEFB1 DEFB4A
50 peanut allergy 10.2 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Osteonecrosis of the Jaw:



Diseases related to Osteonecrosis of the Jaw

Symptoms & Phenotypes for Osteonecrosis of the Jaw

MGI Mouse Phenotypes related to Osteonecrosis of the Jaw:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 CYP19A1 HLA-DQB1 IL17A SEMA4D TGFB1 VEGFA

Drugs & Therapeutics for Osteonecrosis of the Jaw

Search Clinical Trials , NIH Clinical Center for Osteonecrosis of the Jaw

Genetic Tests for Osteonecrosis of the Jaw

Anatomical Context for Osteonecrosis of the Jaw

MalaCards organs/tissues related to Osteonecrosis of the Jaw:

42
Bone, Prostate, T Cells, Kidney, Endothelial, Bone Marrow, Myeloid

Publications for Osteonecrosis of the Jaw

Articles related to Osteonecrosis of the Jaw:

(show top 50) (show all 1091)
# Title Authors Year
1
Necrotizing fasciitis as a complication of osteonecrosis of the jaw related to oral bisphosphonate application in a patient with osteoporosis: a case report. ( 30288621 )
2019
2
Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis. ( 30832685 )
2019
3
Comparison of the histopathological characteristics of osteomyelitis, medication-related osteonecrosis of the jaw, and osteoradionecrosis. ( 30054185 )
2019
4
Value of pre-operative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study. ( 30984311 )
2019
5
Comparison of findings of radiographic and fractal dimension analyses on panoramic radiographs of patients with early-stage and advanced-stage medication-related osteonecrosis of the jaw. ( 31005615 )
2019
6
Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model. ( 31006496 )
2019
7
Pharmacogenomics of osteonecrosis of the jaw. ( 31022475 )
2019
8
A case report of Bisphosphonate Related Osteonecrosis of the Jaw treated by photodynamic therapy. ( 31022581 )
2019
9
Medication-related osteonecrosis of the jaw. Implant presence-triggered osteonecrosis: Case series and literature review. ( 31035023 )
2019
10
Surgical Management of Medication-Related Osteonecrosis of the Jaw Is Associated With Improved Disease Resolution: A Retrospective Cohort Study. ( 31054989 )
2019
11
Preventing medication-related osteonecrosis of the jaw. ( 31068319 )
2019
12
Antiresorptive Agents and Anti-Angiogenesis Drugs in the Development of Osteonecrosis of the Jaw. ( 31080196 )
2019
13
Response to Comment-Osteonecrosis of the Jaw in Myeloma Patients Receiving Denosumab or Zoledronic Acid. Comment on Pivotal Trial by Raje et al. Published in Lancet Oncology. ( 31100871 )
2019
14
Risk factors of medication-related osteonecrosis of the jaw: a retrospective study in a Turkish subpopulation. ( 31106139 )
2019
15
Bibliometric Analysis of Medication-Related Osteonecrosis of the Jaw: High Citation Rates but Low Evidence. ( 31108060 )
2019
16
Medication-related Osteonecrosis of the Jaw: A Literature Review. ( 31109863 )
2019
17
The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw. ( 30641942 )
2019
18
Is the conservative non-surgical management of medication-related osteonecrosis of the jaw an appropriate treatment option for early stages? A long-term single-center cohort study. ( 30642734 )
2019
19
Denosumab-related osteonecrosis of the jaw: a report of 2 cases and review of the literature. ( 30644830 )
2019
20
Surgical therapy for medication-related osteonecrosis of the jaw in osteoporotic patients treated with antiresorptive agents. ( 30647474 )
2019
21
Medication-related osteonecrosis of the jaw after long-term bisphosphonate treatment in a cat. ( 30663796 )
2019
22
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (1), role of imaging in drug-related osteonecrosis of the jaw: An up-to-date review (secondary publication). ( 30705708 )
2019
23
Zoledronate treatment duration is linked to bisphosphonate-related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis. ( 30712276 )
2019
24
Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab-a review. ( 30713092 )
2019
25
Antiresorptive Agent-Related Osteonecrosis of the Jaw (ARONJ): A Twist of Fate in the Bone. ( 30713280 )
2019
26
Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw. ( 30715621 )
2019
27
Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid. ( 30719580 )
2019
28
Correction to: Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells. ( 30721386 )
2019
29
Effects of pH alteration on the pathogenesis of medication-related osteonecrosis of the jaw. ( 30738857 )
2019
30
Both non-surgical dental treatment and extractions increase the risk of medication-related osteonecrosis of the jaw: case-control study. ( 30747305 )
2019
31
Increased risk of bisphosphonate-related osteonecrosis of the jaw in patients with Sjögren's syndrome: nationwide population-based cohort study. ( 30765404 )
2019
32
The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: a case series. ( 30794883 )
2019
33
Osteoporosis therapy in patients with inflammatory rheumatic diseases and osteonecrosis of the jaw. ( 30796524 )
2019
34
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication). ( 30815045 )
2019
35
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (4), CT and MR imaging findings of antiresorptive agent-related osteonecrosis of the jaws/medication-related osteonecrosis of the jaw (secondary publication). ( 30815046 )
2019
36
Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments: Systematic review. ( 30818312 )
2019
37
Clinical significance of periosteal reaction as a predictive factor for treatment outcome of medication-related osteonecrosis of the jaw. ( 30830278 )
2019
38
Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): a qualitative study in England. ( 30833319 )
2019
39
Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management. ( 30840997 )
2019
40
Osteonecrosis of the jaw in the era of targeted therapy and immunotherapy in oncology. ( 30847290 )
2019
41
Medication-Related Osteonecrosis of the Jaw: The Use of Leukocyte-Platelet-Rich Fibrin as an Adjunct in the Treatment. ( 30908443 )
2019
42
Is vitamin D deficiency a risk factor for osteonecrosis of the jaw in patients with cancer? A matched case-control study. ( 30929994 )
2019
43
Ultrasonic Piezoelectric Bone Surgery Combined with L-PRF and Pedicled Buccal Fat Pad Flap in Denosumab-Related Osteonecrosis of the Jaw. ( 30939553 )
2019
44
Tc-99m hydroxymethylene diphosphonate scintigraphy, computed tomography, and magnetic resonance imaging of osteonecrosis in the mandible: Osteoradionecrosis versus medication-related osteonecrosis of the jaw. ( 30941288 )
2019
45
Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw. ( 30949253 )
2019
46
Imaging modalities for drug-related osteonecrosis of the jaw (2), Overview of the position paper on medication-related osteonecrosis of the jaw and the current status of the MRONJ in Japan. ( 30949254 )
2019
47
Medication-related osteonecrosis of the jaw in a minipig model: Parameters for developing a macroscopic, radiological, and microscopic grading scheme. ( 30952472 )
2019
48
Vasculature submucosal changes at early stages of osteonecrosis of the jaw (ONJ). ( 30953717 )
2019
49
Use of Radium-223 Dichloride in Patients With Osteonecrosis of the Jaw Induced by Zoledronic Acid: Report of 2 Cases. ( 30956096 )
2019
50
☆Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (5), utility of bone scintigraphy and 18F-FDG PET/CT in early detection and risk assessment of medication-related osteonecrosis of the jaw (secondary publication). ( 30956739 )
2019

Variations for Osteonecrosis of the Jaw

Expression for Osteonecrosis of the Jaw

Search GEO for disease gene expression data for Osteonecrosis of the Jaw.

Pathways for Osteonecrosis of the Jaw

GO Terms for Osteonecrosis of the Jaw

Cellular components related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 DEFB1 DEFB103B DEFB4A IL17A SEMA4D TGFB1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQB1 HLA-DRB1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DQB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 9.16 HLA-DQB1 HLA-DRB1
5 Golgi lumen GO:0005796 8.92 DEFB1 DEFB103B DEFB4A TGFB1

Biological processes related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.71 SEMA4D TGFB1 VEGFA
2 chemotaxis GO:0006935 9.69 DEFB1 DEFB103B DEFB4A
3 defense response GO:0006952 9.67 DEFB1 DEFB103B DEFB4A
4 defense response to Gram-positive bacterium GO:0050830 9.61 DEFB1 DEFB103B DEFB4A
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 SEMA4D TGFB1 VEGFA
6 mammary gland development GO:0030879 9.55 CYP19A1 TGFB1
7 defense response to Gram-negative bacterium GO:0050829 9.54 DEFB1 DEFB103B DEFB4A
8 positive regulation of protein complex assembly GO:0031334 9.52 TGFB1 VEGFA
9 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.48 TGFB1 VEGFA
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DQB1 HLA-DRB1
11 antimicrobial humoral response GO:0019730 9.43 DEFB1 DEFB103B DEFB4A
12 positive chemotaxis GO:0050918 9.33 DEFB103B DEFB4A VEGFA
13 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.32 HLA-DQB1 HLA-DRB1
14 immune response GO:0006955 9.1 DEFB1 DEFB4A HLA-DQB1 HLA-DRB1 IL17A SEMA4D
15 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1

Molecular functions related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.61 IL17A TGFB1 VEGFA
2 peptide antigen binding GO:0042605 9.4 HLA-DQB1 HLA-DRB1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP19A1 CYP2C8
4 steroid hydroxylase activity GO:0008395 9.32 CYP19A1 CYP2C8
5 aromatase activity GO:0070330 9.26 CYP19A1 CYP2C8
6 MHC class II receptor activity GO:0032395 9.16 HLA-DQB1 HLA-DRB1
7 chemoattractant activity GO:0042056 9.13 DEFB103B DEFB4A VEGFA
8 CCR6 chemokine receptor binding GO:0031731 8.8 DEFB1 DEFB103B DEFB4A

Sources for Osteonecrosis of the Jaw

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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