Osteonecrosis of the Jaw disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OST115 MIFTS: 42	Osteonecrosis of the Jaw Categories: Bone diseases, Oral diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Osteonecrosis of the Jaw

MalaCards integrated aliases for Osteonecrosis of the Jaw:

Name: Osteonecrosis of the Jaw ⁵⁸ ⁷⁵

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Other diseases of jaws

Inflammatory conditions of jaws

Orphanet: ⁵⁸

Rare systemic and rhumatological diseases

Rare bone diseases

External Ids:

ICD10 via Orphanet ³² K10.2

UMLS via Orphanet ⁷² C2711248

Orphanet ⁵⁸ ORPHA399293

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Summaries for Osteonecrosis of the Jaw

Orphanet: ⁵⁸ A rare osteonecrosis characterized by an exposed necrotic lesion in the mandible or maxilla present for more than eight weeks, arising as a complication of antiresorptive medication, dental interventions, or trauma and infections. Patients may present with pain, altered neurosensory functions, secondary infections, and (in advanced stages) pathological fractures, or fistulae.

MalaCards based summary: Osteonecrosis of the Jaw is related to osteonecrosis and periapical periodontitis. An important gene associated with Osteonecrosis of the Jaw is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Chlorhexidine and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and bone marrow, and related phenotypes are growth/size/body region and renal/urinary system

Wikipedia: ⁷⁵ Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the... more...

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Related Diseases for Osteonecrosis of the Jaw

Diseases related to Osteonecrosis of the Jaw via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)

#	Related Disease	Score	Top Affiliating Genes
1	osteonecrosis	31.5	VEGFA TGFB1 NFATC1 IL17A CYP2C8
2	periapical periodontitis	30.5	SIRT1 IL17A
3	osteoporosis	30.2	VEGFA TGFB1 SIRT1 NFATC1 IL17A HLA-DRB1
4	pemphigus	30.0	IL17A HLA-DRB1 HLA-DQB1
5	bone inflammation disease	30.0	VEGFA IL17A HLA-DRB1
6	sarcoidosis 1	29.9	IL17A HLA-DRB1 HLA-DQB1
7	systemic scleroderma	29.8	VEGFA IL17A HLA-DRB1
8	autoimmune disease	29.7	TGFB1 IL17A HLA-DRB1 HLA-DQB1
9	hypothyroidism	29.6	VEGFA IL17A HLA-DRB1 HLA-DQB1
10	type 1 diabetes mellitus	29.6	VEGFA IL17A HLA-DRB1 HLA-DQB1
11	inflammatory bowel disease	28.9	TGFB1 NFATC1 IL17A HLA-DRB1 CYLD
12	dilated cardiomyopathy	28.8	VEGFA TGFB1 SIRT1 IL17A HLA-DRB1 HLA-DQB1
13	diabetes mellitus	28.5	VEGFA TGFB1 SIRT1 PARP1 IL17A HLA-DRB1
14	gnathodiaphyseal dysplasia	11.2
15	myeloma, multiple	11.0
16	bone disease	11.0
17	bone mineral density quantitative trait locus 8	10.9
18	bone mineral density quantitative trait locus 15	10.9
19	osteomyelitis	10.9
20	mammary paget's disease	10.8
21	rapidly involuting congenital hemangioma	10.7
22	periodontitis	10.7
23	twin-reversed arterial perfusion sequence	10.5
24	bone cancer	10.5
25	kidney cancer	10.5
26	renal cell carcinoma, nonpapillary	10.5
27	endosteal hyperostosis, autosomal dominant	10.5
28	prostate cancer	10.5
29	paget's disease of bone	10.5
30	actinomycosis	10.5
31	chronic recurrent multifocal osteomyelitis	10.5
32	rickets	10.5
33	rheumatoid arthritis	10.4
34	maxillary sinusitis	10.4
35	avascular necrosis	10.4
36	prostate cancer, hereditary, 8	10.4
37	brittle bone disorder	10.4
38	prostate cancer, hereditary, 6	10.4
39	fibrous dysplasia	10.4
40	breast cancer	10.4
41	tatton-brown-rahman syndrome	10.4
42	lymphoproliferative syndrome	10.4
43	mucositis	10.4
44	47 xxx syndrome	10.4
45	osteoporosis, juvenile	10.3
46	short stature, onychodysplasia, facial dysmorphism, and hypotrichosis	10.3
47	adult respiratory distress syndrome	10.3
48	gingivitis	10.3
49	collecting duct carcinoma	10.3
50	herpes zoster	10.3

Graphical network of the top 20 diseases related to Osteonecrosis of the Jaw:

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Symptoms & Phenotypes for Osteonecrosis of the Jaw

MGI Mouse Phenotypes related to Osteonecrosis of the Jaw:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.14	BCL6 CYLD HLA-DQB1 HLA-DRB1 IL17A NFATC1
2	renal/urinary system	MP:0005367	10	HLA-DQB1 IL17A PARP1 SEMA4D SIRT1 TGFB1
3	immune system	MP:0005387	10	BCL6 CYLD HERC4 HLA-DQB1 IL17A NFATC1
4	liver/biliary system	MP:0005370	9.98	BCL6 HLA-DQB1 IL17A NFATC1 SIRT1 TGFB1
5	cellular	MP:0005384	9.97	BCL6 CYLD HERC4 HLA-DQB1 NFATC1 PARP1
6	digestive/alimentary	MP:0005381	9.91	CYLD HLA-DQB1 IL17A NFATC1 SIRT1 TGFB1
7	respiratory system	MP:0005388	9.76	BCL6 CYLD HLA-DQB1 IL17A NFATC1 SIRT1
8	hematopoietic system	MP:0005397	9.7	BCL6 CYLD HERC4 HLA-DQB1 IL17A NFATC1
9	integument	MP:0010771	9.23	BCL6 CYLD IL17A NFATC1 PARP1 SIRT1

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Drugs & Therapeutics for Osteonecrosis of the Jaw

Drugs for Osteonecrosis of the Jaw (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Chlorhexidine

Approved, Vet_approved, Withdrawn

Phase 4

55-56-1

2713 9552079

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Clavulanic acid

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Clindamycin

Approved, Vet_approved

Phase 4

18323-44-9, 24729-96-2

29029

Cathine

Approved, Experimental, Illicit, Vet_approved, Withdrawn

Phase 4

14838-15-4, 492-39-7

131954576 4786 26934

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Antibiotics, Antitubercular

Phase 4

Anti-Bacterial Agents

Phase 4

Penicillins

Phase 4

Anti-Infective Agents, Local

Phase 4

Clindamycin phosphate

Phase 4

32603

Clindamycin palmitate

Phase 4

Chlorhexidine gluconate

Phase 4

Disinfectants

Phase 4

Amoxicillin-Potassium Clavulanate Combination

Phase 4

Anti-Infective Agents

Phase 4

Chlorpheniramine, phenylpropanolamine drug combination

Phase 4

Dermatologic Agents

Phase 4

Pentoxifylline

Approved, Investigational

Phase 3

6493-05-6

4740

Tocopherol

Approved, Investigational

Phase 3

1406-66-2

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

Phase 3

59-02-9, 10191-41-0

2116 14985

Tocotrienol

Investigational

Phase 3

6829-55-6

9929901

Radiation-Protective Agents

Phase 3

Vitamins

Phase 3

Trace Elements

Phase 3

Phosphodiesterase Inhibitors

Phase 3

Vasodilator Agents

Phase 3

Platelet Aggregation Inhibitors

Phase 3

Antioxidants

Phase 3

Micronutrients

Phase 3

Protective Agents

Phase 3

Tocotrienols

Phase 3

Tocopherols

Phase 3

Lidocaine, Prilocaine Drug Combination

Phase 1, Phase 2

Angiogenesis Inhibitors

Phase 1, Phase 2

Anesthetics

Phase 1, Phase 2

Levofloxacin

Approved, Investigational

100986-85-4

149096

Ofloxacin

Approved

82419-36-1

4583

Parathyroid hormone

Approved, Investigational

9002-64-6

Denosumab

Approved

615258-40-7

Miconazole

Approved, Investigational, Vet_approved

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

23593-75-1

2812

Teriparatide

Approved, Investigational

52232-67-4

16133850 155817470

Risedronic acid

Approved, Investigational

105462-24-6

5245

Alendronic acid

Approved

121268-17-5, 66376-36-1

2088

Etidronic acid

Approved

2809-21-4, 7414-83-7

3305

Pamidronic acid

Approved

40391-99-9

4674

Ibandronate

Approved, Investigational

114084-78-5

60852

Tiludronic acid

Approved, Investigational, Vet_approved

89987-06-4

60937

Cholecalciferol

Approved, Nutraceutical, Vet_approved

67-97-0, 1406-16-2

5280795 10883523

Interventional clinical trials:

(show all 25)

#	Name	Status	NCT ID	Phase	Drugs
1	A Multicenter Randomized Controlled Open-label Trial of Conservative Management Versus Minimally Invasive Treatment With Leukocyte- and Platelet-rich Fibrin Versus Primary Surgery in Patients With Newly Diagnosed Osteonecrosis of the Jaw	Not yet recruiting	NCT04512638	Phase 4	Antibiotics;Chlorhexidine mouthwash
2	Plasma Rich in Growth Factors for Treatment of Medication Related Osteonecrosis of the Jaw: a Multicenter, Randomized, Clinical Trial	Unknown status	NCT03390777	Phase 2, Phase 3
3	Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment	Enrolling by invitation	NCT03040778	Phase 3	Pentoxifylline;Placebo;Tocopherol
4	OZOPROMAF: Validation Study of the Use of Ozonotherapy in Mronj Management- Protocol of Ozone by Infiltrations in Patients With Osteonecrosis of the Jaws Drug Related	Suspended	NCT05036837	Phase 1, Phase 2	OZOPROMAF_SEQ1
5	Prospective Randomized Clinical Study: Role of Platelet Rich Fibrin (PRF) in the Tooth Extraction Site in the Prevention of Jaw Osteonecrosis on Patients Under Bisphosphonates Therapy	Unknown status	NCT02198001		tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine)
6	Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay.	Unknown status	NCT02218554
7	The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw	Unknown status	NCT03418454
8	Efficacy and Safety on the Use of Bisphosphonates in Paediatrics	Completed	NCT04012320
9	Root Canal Treatment of Compromised Teeth as Alternative Treatment in Patients Under Bisphosphonate Therapy: 60-month Results of a Prospective Clinical Study	Completed	NCT04399720
10	Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer	Completed	NCT01325142
11	A Non-interventional Pharmacovigilance Study of Osteonecrosis of the Jaw and Infection Leading to Hospitalization Among Patients With Cancer Treated With XGEVA™ or Zoledronic Acid in Sweden, Denmark, and Norway	Completed	NCT01967160
12	Trans-PBRN Case-control Study of Osteonecrosis of the Jaws	Completed	NCT01130389
13	Osteonecrosis of the Jaw (ONJ) Case Registry	Completed	NCT01666106
14	Retrospective Cohort Study of ONJ	Completed	NCT01201330
15	Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer: Concordance Study	Completed	NCT00858585
16	Survey of Oncology Practitioners Prescribing XGEVA® in Europe to Evaluate Their Knowledge of XGEVA® Summary of Product Characteristics Pertaining to Osteonecrosis of the Jaw	Completed	NCT01998607
17	S0702: A Prospective Observational Multicenter Cohort Study to Assess the Incidence of Osteonecrosis of the Jaw (ONJ) in Cancer Patients With Bone Metastases Starting Zoledronic Acid Treatment	Completed	NCT00874211
18	The Effect of Concentrated Growth Factor (CGF) in Surgical Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ) in Osteoporosis Patients: a Randomized Controlled Study	Completed	NCT04531800
19	Conservative Versus Surgical Treatment for Medication Related Osteonecrosis of the Jaws (MRONJ) Stages I and II, a Quasi-experimental Clinical Trial With Discovery of Salivary Biomarkers	Recruiting	NCT04584840
20	International, Multicenter, Prospective Registry to Collect Data of Treatment Patterns of Patients With Medication-related Osteonecrosis of the Jaw (MRONJ) and Their Outcome	Recruiting	NCT02932501
21	Phototherapy With Low Level Laser in the Prevention and Treatment of Oral Lesions (Mucositis, Hyposalivation and Osteonecrosis) Resulting From Anti-neoplastic Treatment With Chemotherapy or Radiotherapy.	Recruiting	NCT04717765
22	Biomarker Identification in Orthopaedic and Oral Maxillofacial Subjects	Active, not recruiting	NCT01875458
23	Surgical Management of Stage-2 Medication-Related Osteonecrosis of the Jaw With Transplantation of Human Amniotic Membrane	Active, not recruiting	NCT04967963
24	Pilot Study: Local and Systemic Changes in Osteonecrosis of the Jawbone	Enrolling by invitation	NCT05329558
25	POPULATION PHARMACOMETRICS FOR ASSESSING RISK OF BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW (BRONJ)	Withdrawn	NCT02069340		zoledronic acid

Search NIH Clinical Center for Osteonecrosis of the Jaw

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Genetic Tests for Osteonecrosis of the Jaw

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Anatomical Context for Osteonecrosis of the Jaw

Organs/tissues related to Osteonecrosis of the Jaw:

MalaCards : Bone, Breast, Bone Marrow, Prostate, T Cells, Endothelial, Lung

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Publications for Osteonecrosis of the Jaw

Articles related to Osteonecrosis of the Jaw:

(show top 50) (show all 2818)

#	Title	Authors	PMID	Year
1	Quantitative Real-Time Gene Profiling of Human Alveolar Osteoblasts Using a One-Step System. ⁶²	Coates DE...Milne TJ	36418701	2023
2	World Workshop on Oral Medicine VII: Oral adverse effects to biologic agents in patients with inflammatory disorders. A scoping review. ⁶²	France K...Carey B	36455995	2022
3	A systematic review and meta-analysis of interventional studies of bisphosphonates and denosumab in multiple myeloma and future perspectives. ⁶²	Chatziravdeli V...Zintzaras E	36458395	2022
4	Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw. ⁶²	Minami Y...Ogura I	36345763	2022
5	Response to: Prognosis of metastatic bone cancer and myeloma patients and long‑term risk of medication‑related osteonecrosis of the jaw (MRONJ): some critical points. ⁶²	Hata H...Kitagawa Y	36318340	2022
6	Prognosis of metastatic bone cancer and myeloma patients and long-term risk of medication-related osteonecrosis of the jaw (MRONJ): some critical points. ⁶²	Fusco V...Palmeri S	35882670	2022
7	Evaluation of advanced platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam. ⁶²	Straub A...Hartmann S	35941396	2022
8	Osteonecrosis of the Jaw Caused by Denosumab in Treatment-Naïve and Pre-Treatment with Zoledronic Acid Groups: A Time-to-Onset Study Using the Japanese Adverse Drug Event Report (JADER) Database. ⁶²	Hasegawa S...Nakamura M	35933498	2022
9	Assessment of clinical guidelines for medication-related osteonecrosis of the jaw: current status and future directions. ⁶²	Barrette LX...Rajasekaran K	36241597	2022
10	Platelet-derived growth factors from a single donor by apheresis and one freeze-thaw cycle for treating medication-related osteonecrosis of the jaw. ⁶²	Vidan-Estevez J...Seco-Calvo J	36169261	2022
11	Convolutional neural network for automated classification of osteonecrosis and related mandibular trabecular patterns. ⁶²	Baseri Saadi S...Jacobs R	36389628	2022
12	The Role of Bone Grafts in Preventing Medication-Related Osteonecrosis of the Jaw: Histomorphometric, Immunohistochemical, and Clinical Evaluation in Animal Model. ⁶²	da Silva JR...Hochuli-Vieira E	36387320	2022
13	Incidence and risk factors for medication-related osteonecrosis after tooth extraction in cancer patients-A systematic review. ⁶²	Schwech N...Gabre P	36464958	2022
14	Correction to: Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw. ⁶²	Moll S...Klingelhoffer C	34841455	2022
15	Is medication related osteonecrosis of the jaw around implants a rare entity? A case series with a focus on etiopathophysiology. ⁶²	Massaad J...Magremanne M	34922047	2022
16	Re: AAOMS Position Paper on Medication-Related Osteonecrosis of the Jaw-2022 Update. ⁶²	Campisi G...Fusco V	36332990	2022
17	A liquid chromatography-tandem mass spectrometry method for the quantification of ampicillin/sulbactam and clindamycin in jawbone, plasma, and platelet-rich fibrin: Application to patients with osteonecrosis of the jaw. ⁶²	Stapf M...Scherf-Clavel O	36435082	2022
18	Medication-related osteonecrosis of the jaw triggered by endodontic failure in oncologic patients. ⁶²	Tempesta A...Limongelli L	36403223	2022
19	Organic Bone Matrix Component Type I and V Collagen Are Not Destructed in Bisphosphonate-Associated Osteonecrosis of the Jaws. ⁶²	Acil Y...Gulses A	36422230	2022
20	Clinical risk factors for severity and prognosis of antiresorptive agent-related osteonecrosis of the jaw: a retrospective observational study. ⁶²	Nashi M...Takenobu T	36166107	2022
21	The "Phoenix Jaw" Phenomenon Revisited: Two Cases of Bisphosphonate-Related Mandible Osteonecrosis Surgically Treated with Complete Bone Regeneration. ⁶²	Romanos GN...Samonis G	36123026	2022
22	Actinomycosis and osteonecrosis of the jaw: Every why hides a why. ⁶²	Arnal Etienne A...Magremanne M	35640875	2022
23	Medication-related osteonecrosis of the jaw: Prosthodontic considerations. ⁶²	Ali IE...Sumita Y	34984072	2022
24	Osteonecrosis of the jaw among cancer patients in Denmark: risk and prognosis. ⁶²	Gadgaard NR...Ehrenstein V	35279336	2022
25	Long-term consequences of osteoporosis therapy with denosumab. ⁶²	Bandeira F...Bilezikian JP	36382761	2022
26	Bone Concentration of Ampicillin/Sulbactam: A Pilot Study in Patients with Osteonecrosis of the Jaw. ⁶²	Straub A...Hartmann S	36429636	2022
27	A comparative study of the clinical characteristics of patients with medication-related osteonecrosis of the jaw and osteoporosis or malignancy. ⁶²	Feng Z...Zhang Y	35668004	2022
28	Analysis of the effect of zoledronic acid on gene differences in rat jaw. ⁶²	Zhang S...Dong R	35390513	2022
29	Bone Morphogenetic Protein 2 Plus Leukocyte and Platelet-Rich Fibrin for the Treatment of MRONJ. ⁶²	Moraes-da-Silva AF...Santos PSDS	36217220	2022
30	Bevacizumab and sunitinib mediate osteogenic and pro-inflammatory molecular changes in primary human alveolar osteoblasts in vitro. ⁶²	Hofmann E...Gotz W	35171372	2022
31	Cytoprotective effect of Fridericia chica (Bonpl.) L.G. Lohmann extract associated with geranylgeraniol enriched-fraction from Bixa orellana L. on epithelial cells treated with bisphosphonate. ⁶²	Machado Junior RJ...Foglio MA	36226767	2022
32	Medication-related osteonecrosis of the jaw after tooth extraction in patients receiving pharmaceutical treatment for osteoporosis: A retrospective cohort study. ⁶²	Seki K...Iinuma T	36299343	2022
33	Maximum standardized uptake value of normal structures in the head and neck with bone SPECT/CT. ⁶²	Tezuka Y...Ogura I	34989162	2022
34	Treatment outcomes of proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for locally advanced oral cancer in the elderly. ⁶²	Kitabatake T...Mitsudo K	35125267	2022
35	Medication-related osteonecrosis of the jaw and successful implant treatment in a patient on high-dose antiresorptive medication: A case report. ⁶²	Ottesen C...Gotfredsen K	35894761	2022
36	The Effect of Antiresorptive Drug Holidays on Medication-Related Osteonecrosis of the Jaw: A Systematic Review and Meta-Analysis. ⁶²	Aboalela AA...Almohammadi DS	36415385	2022
37	Reply to Potential Issues With the Use of Teriparatide After Denosumab-Related Osteonecrosis of the Jaw. ⁶²	Everts-Graber J...Lehmann T	35924400	2022
38	Denosumab-Related Osteonecrosis of the Jaw May Not Be a Subject of Teriparatide Treatment. ⁶²	Park KS...Kim KJ	35751544	2022
39	Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw. ⁶²	Hadad H...Avila Souza F	36192619	2022
40	Idiopathic lingual mandibular sequestration and its relationship to medication-related osteonecrosis of the jaws (MRONJ): mini review. ⁶²	Vyas R...Katz J	36169274	2022
41	Association Between Malignant Diseases and Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review and Meta-Analysis. ⁶²	Yao S...Zhang B	36184756	2022
42	Vascular Analysis of Soft Tissues Around the Bone Lesion in Osteoradionecrosis, Medication-Related Osteonecrosis, and Infectious Osteomyelitis of the Jaw. ⁶²	Wang Z...Du Y	36201691	2022
43	Medication-Related Osteonecrosis of the Jaw: 14 Years' Retrospective Study on Pathogenetic Trigger Events. ⁶²	Marino R...Nastro Siniscalchi E	36201694	2022
44	Medication-related osteonecrosis of the jaw, a risk to reassess in osteoporotic patients. ⁶²	Debieve M...Magremanne M	36273739	2022
45	Medication-Related Osteonecrosis of the Jaw Associated in a Patient Treated With Etanercept. ⁶²	Nisi M...Graziani F	35184115	2022
46	Possible association of methotrexate use with osteonecrosis of the jaw: Systematic review. ⁶²	Milosavljevic M...Jankovic S	35306206	2022
47	One changing and challenging scenario: the treatment of cancer patients with bone metastases by bisphosphonates and denosumab, the cost-benefit evaluation of different options, and the risk of medication-related osteonecrosis of the jaw (MRONJ). ⁶²	Fusco V...Bedogni A	35312858	2022
48	Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study. ⁶²	Winter A...Hartmann S	36141982	2022
49	Medication-related osteonecrosis of the jaw after dental clearance: Prevalence in an oncology center. ⁶²	Hajeri S...Alturkistany Y	36092518	2022
50	Osteonecrosis of the jaw in primary dental care: Recognition and referral. ⁶²	Burns M...Patel V	36073051	2022

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Genes for Osteonecrosis of the Jaw

Genes related to Osteonecrosis of the Jaw (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	8.67	GeneCards inferred via : Publications (show sections)
2	SIRT1	Sirtuin 1	Protein Coding	8.41	GeneCards inferred via : Publications (show sections)
3	BCL6	BCL6 Transcription Repressor	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
4	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
5	HERC4	HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
6	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
7	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
8	IL17A	Interleukin 17A	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
9	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
10	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
11	RBMS3	RNA Binding Motif Single Stranded Interacting Protein 3	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
12	SEMA4D	Semaphorin 4D	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
13	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)
14	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	8.06	GeneCards inferred via : Publications (show sections)

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Variations for Osteonecrosis of the Jaw

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Expression for Osteonecrosis of the Jaw

Search GEO for disease gene expression data for Osteonecrosis of the Jaw.

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Pathways for Osteonecrosis of the Jaw

Pathways related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.53	VEGFA TGFB1 NFATC1 IL17A HLA-DRB1 HLA-DQB1
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.96	BCL6 HLA-DQB1 HLA-DRB1 IL17A TGFB1 VEGFA
3	NF-kappaB Signaling ³	12.27	NFATC1 IL17A CYLD BCL6
4	Vitamin D receptor pathway ⁷⁴	12	TGFB1 HLA-DRB1 BCL6
5	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.89	NFATC1 IL17A HLA-DRB1
6	Clock-controlled autophagy in bone metabolism ⁷⁴	11.45	TGFB1 SEMA4D NFATC1
7	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.29	VEGFA TGFB1 IL17A BCL6
8	Th17 cell differentiation pathway ⁷⁴	11.27	TGFB1 NFATC1 IL17A
9	THC Differentiation Pathway ⁶⁴	11.26	NFATC1 HLA-DRB1 HLA-DQB1
10	Cytokines and inflammatory response ⁷⁴	11.03	TGFB1 HLA-DRB1
11	Prostaglandin signaling ⁷⁴	10.99	VEGFA IL17A
12	Allograft rejection ⁷⁴	10.99	VEGFA TGFB1 IL17A HLA-DRB1 HLA-DQB1
13	Glypican 1 network ⁶¹	10.8	VEGFA TGFB1
14	Interactions between LOXL4 and oxidative stress pathway ⁷⁴	10.77	TGFB1 SIRT1
15	Immune infiltration in pancreatic cancer ⁷⁴	10.76	VEGFA TGFB1 IL17A
16	NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence ⁷⁴	10.73	SIRT1 PARP1
17	NAD metabolism, sirtuins and aging ⁷⁴	10.47	SIRT1 PARP1

Sources

GO Terms for Osteonecrosis of the Jaw

Biological processes related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.89	VEGFA TGFB1 SEMA4D
2	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.88	VEGFA SIRT1 SEMA4D
3	cellular response to transforming growth factor beta stimulus	GO:0071560	9.83	TGFB1 PARP1 NFATC1
4	positive regulation of protein phosphorylation	GO:0001934	9.81	VEGFA TGFB1 SIRT1 SEMA4D HLA-DRB1
5	positive regulation of transcription regulatory region DNA binding	GO:2000679	9.69	TGFB1 PARP1
6	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.65	VEGFA TGFB1 SIRT1
7	positive regulation of vascular permeability	GO:0043117	9.63	VEGFA TGFB1
8	positive regulation of smooth muscle cell differentiation	GO:0051152	9.5	SIRT1 TGFB1
9	immunoglobulin production involved in immunoglobulin-mediated immune response	GO:0002381	9.4	HLA-DRB1 HLA-DQB1
10	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	9.37	HLA-DRB1 HLA-DQB1
11	positive regulation of histone deacetylation	GO:0031065	9.35	TGFB1 SIRT1 BCL6
12	macrophage differentiation	GO:0030225	9.23	VEGFA SIRT1 PARP1 HLA-DRB1