MCID: OST115
MIFTS: 38

Osteonecrosis of the Jaw

Categories: Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Osteonecrosis of the Jaw

MalaCards integrated aliases for Osteonecrosis of the Jaw:

Name: Osteonecrosis of the Jaw 60

Classifications:



External Ids:

ICD10 via Orphanet 35 K10.2
UMLS via Orphanet 75 C2711248
Orphanet 60 ORPHA399293

Summaries for Osteonecrosis of the Jaw

MalaCards based summary : Osteonecrosis of the Jaw is related to osteonecrosis and periodontal disease. An important gene associated with Osteonecrosis of the Jaw is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include bone, breast and prostate, and related phenotype is renal/urinary system.

Wikipedia : 77 Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the... more...

Related Diseases for Osteonecrosis of the Jaw

Diseases related to Osteonecrosis of the Jaw via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 32.5 CYP2C8 FDPS VEGFA
2 periodontal disease 30.5 DEFB1 DEFB4A IL17A
3 arthritis 30.4 HLA-DQB1 HLA-DRB1 IL17A TGFB1
4 rheumatoid arthritis 30.1 HLA-DQB1 HLA-DRB1 IL17A TGFB1 VEGFA
5 myeloma, multiple 10.8
6 osteoporosis 10.8
7 breast cancer 10.7
8 prostate cancer 10.6
9 prostate cancer, hereditary, 8 10.6
10 prostate cancer, hereditary, 6 10.6
11 osteomyelitis 10.5
12 bone mineral density quantitative trait locus 8 10.4
13 bone mineral density quantitative trait locus 15 10.4
14 cerebrotendinous xanthomatosis 10.4
15 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
16 periodontitis 10.3
17 rapidly involuting congenital hemangioma 10.3
18 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
19 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
20 hypersomnia 10.3 HLA-DQB1 HLA-DRB1
21 metal allergy 10.3 HLA-DQB1 HLA-DRB1
22 lichen planopilaris 10.3 HLA-DQB1 HLA-DRB1
23 type ii mixed cryoglobulinemia 10.3 HLA-DQB1 HLA-DRB1
24 beryllium disease 10.3 HLA-DQB1 HLA-DRB1
25 recurrent respiratory papillomatosis 10.3 HLA-DQB1 HLA-DRB1
26 narcolepsy 1 10.3 HLA-DQB1 HLA-DRB1
27 chronic beryllium disease 10.3 HLA-DQB1 HLA-DRB1
28 central nervous system vasculitis 10.3 HLA-DRB1 IL17A
29 lichen sclerosus 10.3 HLA-DQB1 HLA-DRB1
30 whipple disease 10.3 HLA-DQB1 HLA-DRB1
31 pityriasis rosea 10.3 HLA-DQB1 HLA-DRB1
32 pediatric multiple sclerosis 10.3 HLA-DQB1 HLA-DRB1
33 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 HLA-DRB1 IL17A
34 microscopic colitis 10.2 HLA-DQB1 HLA-DRB1
35 cystic echinococcosis 10.2 HLA-DRB1 IL17A
36 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
37 bone disease 10.2
38 bone resorption disease 10.2
39 thrombophilia 10.2
40 endophthalmitis 10.2 DEFB1 VEGFA
41 peanut allergy 10.2 HLA-DQB1 HLA-DRB1
42 pure red-cell aplasia 10.2 HLA-DQB1 HLA-DRB1
43 diabetes mellitus 10.2
44 herpes zoster 10.2
45 fasciitis 10.2
46 necrotizing fasciitis 10.2
47 panuveitis 10.2 HLA-DQB1 HLA-DRB1 IL17A
48 corneal abscess 10.2 DEFB1 DEFB4A
49 vogt-koyanagi-harada disease 10.2 HLA-DQB1 HLA-DRB1 IL17A
50 geographic tongue 10.2 HLA-DQB1 HLA-DRB1 VEGFA

Graphical network of the top 20 diseases related to Osteonecrosis of the Jaw:



Diseases related to Osteonecrosis of the Jaw

Symptoms & Phenotypes for Osteonecrosis of the Jaw

MGI Mouse Phenotypes related to Osteonecrosis of the Jaw:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 CYP19A1 HLA-DQB1 IL17A SEMA4D TGFB1 VEGFA

Drugs & Therapeutics for Osteonecrosis of the Jaw

Search Clinical Trials , NIH Clinical Center for Osteonecrosis of the Jaw

Genetic Tests for Osteonecrosis of the Jaw

Anatomical Context for Osteonecrosis of the Jaw

MalaCards organs/tissues related to Osteonecrosis of the Jaw:

42
Bone, Breast, Prostate, Endothelial, T Cells, Bone Marrow, Kidney

Publications for Osteonecrosis of the Jaw

Articles related to Osteonecrosis of the Jaw:

(show top 50) (show all 1065)
# Title Authors Year
1
Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis. ( 30832685 )
2019
2
Medication-Related Osteonecrosis of the Jaw: The Use of Leukocyte-Platelet-Rich Fibrin as an Adjunct in the Treatment. ( 30908443 )
2019
3
Influence of induced infection in medication-related osteonecrosis of the jaw development after tooth extraction: A study in rats. ( 30595476 )
2019
4
Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review. ( 30595601 )
2019
5
Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw. ( 30624969 )
2019
6
Evaluation of medication-related osteonecrosis of the jaw using the Japanese Adverse Drug Event Report database. ( 30636879 )
2019
7
The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw. ( 30641942 )
2019
8
Is the conservative non-surgical management of medication-related osteonecrosis of the jaw an appropriate treatment option for early stages? A long-term single-center cohort study. ( 30642734 )
2019
9
Denosumab-related osteonecrosis of the jaw: a report of 2 cases and review of the literature. ( 30644830 )
2019
10
Surgical therapy for medication-related osteonecrosis of the jaw in osteoporotic patients treated with antiresorptive agents. ( 30647474 )
2019
11
Medication-related osteonecrosis of the jaw after long-term bisphosphonate treatment in a cat. ( 30663796 )
2019
12
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (1), role of imaging in drug-related osteonecrosis of the jaw: An up-to-date review (secondary publication). ( 30705708 )
2019
13
Zoledronate Treatment Duration Is Linked to Bisphosphonate-Related ONJ Prevalence in Rice Rats with Generalized Periodontitis. ( 30712276 )
2019
14
Antiresorptive Agent-Related Osteonecrosis of the Jaw (ARONJ): A Twist of Fate in the Bone. ( 30713280 )
2019
15
Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw. ( 30715621 )
2019
16
Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid. ( 30719580 )
2019
17
Correction to: Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells. ( 30721386 )
2019
18
Effects of pH alteration on the pathogenesis of medication-related osteonecrosis of the jaw. ( 30738857 )
2019
19
Both non-surgical dental treatment and extractions increase the risk of medication-related osteonecrosis of the jaw: case-control study. ( 30747305 )
2019
20
Increased risk of bisphosphonate-related osteonecrosis of the jaw in patients with Sjögren's syndrome: nationwide population-based cohort study. ( 30765404 )
2019
21
The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: a case series. ( 30794883 )
2019
22
Osteoporosis therapy in patients with inflammatory rheumatic diseases and osteonecrosis of the jaw. ( 30796524 )
2019
23
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication). ( 30815045 )
2019
24
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (4), CT and MR imaging findings of antiresorptive agent-related osteonecrosis of the jaws/medication-related osteonecrosis of the jaw (secondary publication). ( 30815046 )
2019
25
Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments: Systematic review. ( 30818312 )
2019
26
Clinical significance of periosteal reaction as a predictive factor for treatment outcome of medication-related osteonecrosis of the jaw. ( 30830278 )
2019
27
Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): a qualitative study in England. ( 30833319 )
2019
28
Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management. ( 30840997 )
2019
29
Osteonecrosis of the jaw in the era of targeted therapy and immunotherapy in oncology. ( 30847290 )
2019
30
Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis. ( 30184271 )
2019
31
Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment. ( 30393090 )
2019
32
Medication-related osteonecrosis of the jaw after tooth extraction in cancer patients: a multicenter retrospective study. ( 30406309 )
2019
33
Comorbid conditions are a risk for osteonecrosis of the jaw unrelated to antiresorptive therapy. ( 30449690 )
2019
34
Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study. ( 29680992 )
2019
35
Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective. ( 29955628 )
2018
36
Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management. ( 29799056 )
2018
37
Chronic myelogenous leukemia presenting with osteonecrosis of the jaw as a rare but debilitating toxicity of dasatinib: a case report and literature review. ( 29941400 )
2018
38
Osteonecrosis of the Jaw and Rebound Hypercalcemia in Young People Treated With Denosumab for Giant Cell Tumor of Bone. ( 29211870 )
2018
39
Development of antiresorptive agent-related osteonecrosis of the jaw after dental implant removal: a case report. ( 29870295 )
2018
40
Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice. ( 29729428 )
2018
41
Early removal of sequestrum in patients affected by medication-related osteonecrosis of the jaw. ( 29422306 )
2018
42
Machine learning to predict the occurrence of bisphosphonate-related osteonecrosis of the jaw associated with dental extraction: A preliminary report. ( 29698784 )
2018
43
Conservative surgical treatment of medication related osteonecrosis of the jaw (MRONJ) lesions in patients affected by osteoporosis exposed to oral bisphosphonates: 24 months follow-up. ( 29802059 )
2018
44
Microbial population changes in patients with medication-related osteonecrosis of the jaw treated with systemic antibiotics. ( 29325851 )
2018
45
Recommendations for the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Systematic Review. ( 29747794 )
2018
46
Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-NaA^ve Patient: A Comprehensive Review of the Literature. ( 29850569 )
2018
47
Osteonecrosis of the Jaw in a Patient With Bone Metastatic Prostate Cancer After Long-term Bisphosphonate Treatment With Severe Deterioration Following Radium-223. ( 29861164 )
2018
48
Comment on "Nasolabial Flap Improves Healing in Medication-Related Osteonecrosis of the Jaw" by Lemound etA al. ( 29902417 )
2018
49
Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis. ( 29289789 )
2018
50
Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. ( 29408511 )
2018

Variations for Osteonecrosis of the Jaw

Expression for Osteonecrosis of the Jaw

Search GEO for disease gene expression data for Osteonecrosis of the Jaw.

Pathways for Osteonecrosis of the Jaw

GO Terms for Osteonecrosis of the Jaw

Cellular components related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 DEFB1 DEFB103B DEFB4A IL17A SEMA4D TGFB1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQB1 HLA-DRB1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DQB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 9.16 HLA-DQB1 HLA-DRB1
5 Golgi lumen GO:0005796 8.92 DEFB1 DEFB103B DEFB4A TGFB1

Biological processes related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.71 SEMA4D TGFB1 VEGFA
2 chemotaxis GO:0006935 9.69 DEFB1 DEFB103B DEFB4A
3 defense response GO:0006952 9.67 DEFB1 DEFB103B DEFB4A
4 defense response to Gram-positive bacterium GO:0050830 9.61 DEFB1 DEFB103B DEFB4A
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 SEMA4D TGFB1 VEGFA
6 mammary gland development GO:0030879 9.55 CYP19A1 TGFB1
7 defense response to Gram-negative bacterium GO:0050829 9.54 DEFB1 DEFB103B DEFB4A
8 positive regulation of protein complex assembly GO:0031334 9.52 TGFB1 VEGFA
9 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.48 TGFB1 VEGFA
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DQB1 HLA-DRB1
11 antimicrobial humoral response GO:0019730 9.43 DEFB1 DEFB103B DEFB4A
12 positive chemotaxis GO:0050918 9.33 DEFB103B DEFB4A VEGFA
13 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.32 HLA-DQB1 HLA-DRB1
14 immune response GO:0006955 9.1 DEFB1 DEFB4A HLA-DQB1 HLA-DRB1 IL17A SEMA4D
15 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1

Molecular functions related to Osteonecrosis of the Jaw according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.61 IL17A TGFB1 VEGFA
2 peptide antigen binding GO:0042605 9.4 HLA-DQB1 HLA-DRB1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP19A1 CYP2C8
4 steroid hydroxylase activity GO:0008395 9.32 CYP19A1 CYP2C8
5 aromatase activity GO:0070330 9.26 CYP19A1 CYP2C8
6 MHC class II receptor activity GO:0032395 9.16 HLA-DQB1 HLA-DRB1
7 chemoattractant activity GO:0042056 9.13 DEFB103B DEFB4A VEGFA
8 CCR6 chemokine receptor binding GO:0031731 8.8 DEFB1 DEFB103B DEFB4A

Sources for Osteonecrosis of the Jaw

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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