OSTEOP
MCID: OST002
MIFTS: 73

Osteoporosis (OSTEOP)

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Osteoporosis

MalaCards integrated aliases for Osteoporosis:

Name: Osteoporosis 56 12 74 73 36 54 6 42 43 15 37 62 39 17 71
Postmenopausal Osteoporosis 73 29 6 17 32
Osteoporosis, Postmenopausal 56 71
Osteoporosis, Involutional 56 13
Bone Mineral Density Quantitative Trait Locus; Bmnd 56
Bone Mineral Density Variation Qtl, Osteoporosis 56
Bone Mineral Density, Quantitative Trait Locus 39
Bone Mineral Density Quantitative Trait Locus 56
Osteoporosis, Postmenopausal, Susceptibility 56
Osteoporosis, Susceptibility to 56
Osteoporosis Postmenopausal 54
Involutional Osteoporosis 73
Osteoporosis, Senile 71
Senile Osteoporosis 73
Osteop 73
Bmnd 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
osteoporosis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11476
OMIM 56 166710
KEGG 36 H01593
ICD9CM 34 733.0 733.00
MeSH 43 D010024
NCIt 49 C3298
SNOMED-CT 67 64859006
SNOMED-CT via HPO 68 263681008
UMLS 71 C0029456 C0029458 C0029459

Summaries for Osteoporosis

MedlinePlus : 42 Osteoporosis is a disease that thins and weakens the bones. Your bones become fragile and fracture (break) easily, especially the bones in the hip, spine, and wrist. In the United States, millions of people either already have osteoporosis or are at high risk due to low bone mass. Anyone can develop osteoporosis, but it is more common in older women. Risk factors include Getting older Being small and thin Having a family history of osteoporosis Taking certain medicines Being a white or Asian woman Having low bone density Osteoporosis is a silent disease. You might not know you have it until you break a bone. A bone mineral density test is the best way to check your bone health. To keep bones strong, eat a diet rich in calcium and vitamin D, exercise, and do not smoke. If needed, medicines can also help. It is also important to try to avoid falling down. Falls are the number one cause of fractures in older adults. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteoporosis, also known as postmenopausal osteoporosis, is related to osteoporosis, juvenile and bone mineral density quantitative trait locus 15, and has symptoms including tremor, angina pectoris and back pain. An important gene associated with Osteoporosis is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Osteoclast differentiation and Mineral absorption. The drugs Linagliptin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include Bone, and related phenotypes are osteoporosis and limbs/digits/tail

Disease Ontology : 12 A bone resorption disease characterized by decreased density of normally mineralized bone which results in the thinning of bone tissue and decreased mechanical strength.

KEGG : 36 Osteoporosis is a common disease characterised by a generalised reduction in bone mineral density (BMD), microarchitectural deterioration of bone tissue and an increased risk of fracture. Since BMD values fall progressively with age, the prevalence of osteoporosis increases with age. It has been estimated that approximately 50% of all women will have osteoporosis by the age of 80. Studies in twins and families indicate that genetic factors play an important role in the regulation of BMD and other determinants of osteoporotic fracture risk. Osteoporosis is a polygenic disorder, determined by the effects of several genes, each with relatively modest effects. Population-based studies and case-control studies have similarly identified polymorphisms in several candidate genes that have been associated with bone mass or osteoporotic fracture, including the vitamin D receptor, oestrogen receptor and collagen gene. Bisphosphonates, and in some patients denosumab, are first-line drugs for osteoporosis.

UniProtKB/Swiss-Prot : 73 Osteoporosis: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.

PubMed Health : 62 About osteoporosis: Having weak bones that easily break is a sign of osteoporosis. It is normal for your bones to become less dense as you grow older, but osteoporosis speeds up this process. This condition can particularly lead to problems in older age because broken bones do not heal as easily in older people as they do in young people, and the consequences are more serious. In general, osteoporosis is more common in women, and they often develop it at a younger age. Getting older does not mean that you will automatically develop osteoporosis, but the risk does increase with age. People over the age of 70 are more likely to have low bone density. Plus, the risk of falling increases in old age, which then also makes fractures more likely. But there are several things you can do to protect and strengthen your bones – even if you are already older.

Wikipedia : 74 Osteoporosis is a disease in which bone weakening increases the risk of a broken bone. It is the most... more...

More information from OMIM: 166710

Related Diseases for Osteoporosis

Diseases in the Osteoporosis family:

Osteoporosis, Juvenile Juvenile Primary Osteoporosis
Lrp5-Related Primary Osteoporosis

Diseases related to Osteoporosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 1063, show less)
# Related Disease Score Top Affiliating Genes
1 osteoporosis, juvenile 35.9 WNT1 LRP5 COL1A2 COL1A1
2 bone mineral density quantitative trait locus 15 34.6 PDLIM4 CALCR
3 bone disease 33.9 VDR LRP5 ESR1 DANCR COL1A1
4 bone resorption disease 33.6 VDR LRP5 ESR1 COL1A2 COL1A1 CALCR
5 brittle bone disorder 32.4 WNT1 LRP5 COL1A2 COL1A1
6 sclerosteosis 32.1 VDR LRP5 COL1A1
7 scleroderma, familial progressive 31.4 COL1A2 COL1A1
8 van buchem disease 31.4 VDR LRP5 COL1A1
9 scoliosis 31.3 VDR ESR1 COL1A2 COL1A1
10 otosclerosis 31.2 VDR COL1A2 COL1A1
11 col1a1/2 osteogenesis imperfecta 31.1 COL1A2 COL1A1
12 bone cancer 30.9 VDR ESR1 COL1A1
13 osteogenesis imperfecta, type iii 30.7 WNT1 COL1A2 COL1A1
14 protrusio acetabuli 30.7 VDR ESR1
15 osteogenesis imperfecta, type v 30.6 COL1A2 COL1A1
16 ehlers-danlos syndrome, classic type, 1 30.5 COL1A2 COL1A1
17 syringomyelia 30.4 VDR COL1A1
18 bone mineral density quantitative trait locus 9 12.8
19 bone mineral density quantitative trait locus 10 12.8
20 bone mineral density quantitative trait locus 11 12.8
21 bone mineral density quantitative trait locus 13 12.8
22 bone mineral density quantitative trait locus 14 12.8
23 osteoporosis-pseudoglioma syndrome 12.8
24 bone mineral density quantitative trait locus 4 12.7
25 bone mineral density quantitative trait locus 5 12.7
26 bone mineral density quantitative trait locus 6 12.7
27 nephrolithiasis/osteoporosis, hypophosphatemic, 1 12.6
28 glucocorticoid-induced osteoporosis 12.6
29 juvenile primary osteoporosis 12.6
30 nephrolithiasis/osteoporosis, hypophosphatemic, 2 12.5
31 osteoporosis and oculocutaneous hypopigmentation syndrome 12.5
32 macroepiphyseal dysplasia with osteoporosis, wrinkled skin, and aged appearance 12.3
33 hajdu-cheney syndrome 12.2
34 growth failure, microcephaly, mental retardation, cataracts, large joint contractures, osteoporosis, cortical dysplasia, and cerebellar atrophy 12.2
35 dominant hypophosphatemia with nephrolithiasis or osteoporosis 12.2
36 bone mineral density quantitative trait locus 8 12.2
37 amino aciduria with mental deficiency, dwarfism, muscular dystrophy, osteoporosis, and acidosis 12.2
38 cutis laxa osteoporosis 12.1
39 osteoporosis-macrocephaly-blindness-joint hyperlaxity syndrome 12.1
40 lrp5-related primary osteoporosis 12.1
41 bone mineral density quantitative trait locus 18 12.0
42 bone mineral density quantitative trait locus 16 11.8
43 premature ovarian failure 1 11.7
44 werner syndrome 11.6
45 aromatase deficiency 11.6
46 bone mineral density quantitative trait locus 12 11.6
47 rickets 11.6
48 syndromic x-linked intellectual disability snyder type 11.6
49 lysinuric protein intolerance 11.5
50 mental retardation, x-linked, syndromic, snyder-robinson type 11.5
51 geroderma osteodysplasticum 11.5
52 hyperparathyroidism 11.5
53 premature aging syndrome, okamoto type 11.5
54 cerebrotendinous xanthomatosis 11.4
55 acth-secreting pituitary adenoma 11.4
56 cholangitis, primary sclerosing 11.4
57 spondyloocular syndrome 11.4
58 cleidocranial dysplasia 11.4
59 anorexia nervosa 11.4
60 celiac disease 1 11.4
61 systemic mastocytosis 11.4
62 eating disorder 11.3
63 osteopetrosis 11.3
64 hypogonadotropic hypogonadism 11.3
65 multicentric osteolysis, nodulosis, and arthropathy 11.3
66 graves' disease 11.3
67 turner syndrome 11.3
68 severe congenital neutropenia 11.3
69 pituitary adenoma 4, acth-secreting 11.3
70 homocystinuria 11.3
71 calvarial doughnut lesions with bone fragility 11.3
72 exudative vitreoretinopathy 11.3
73 spinal disease 11.3
74 cleft palate, isolated 11.3
75 menkes disease 11.3
76 parathyroid carcinoma 11.3
77 dyskeratosis congenita 11.3
78 kallmann syndrome 11.3
79 47, xxy 11.3
80 winchester syndrome 11.3
81 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.2
82 mucolipidosis iii alpha/beta 11.2
83 nestor-guillermo progeria syndrome 11.2
84 bone remodeling disease 11.2 VDR LRP5 ESR1 COL1A2 COL1A1 CALCR
85 hyperparathyroidism 1 11.1
86 dyskeratosis congenita, autosomal recessive 1 11.1
87 hyaline fibromatosis syndrome 11.1
88 mucolipidosis iii gamma 11.1
89 prader-willi habitus, osteopenia, and camptodactyly 11.1
90 osteogenesis imperfecta, type xii 11.1
91 dyskeratosis congenita, autosomal dominant 2 11.1
92 osteogenesis imperfecta, type xiii 11.1
93 dyskeratosis congenita, autosomal recessive 5 11.1
94 pigmented nodular adrenocortical disease, primary, 4 11.1
95 dyskeratosis congenita, autosomal dominant 6 11.1
96 ehlers-danlos syndrome, classic-like, 2 11.1
97 odontochondrodysplasia 11.1 WNT1 LRP5 COL1A2 COL1A1
98 dyskeratosis congenita, autosomal dominant 1 11.0
99 hyperparathyroidism 2 with jaw tumors 11.0
100 singleton-merten syndrome 1 11.0
101 aspartylglucosaminuria 11.0
102 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 11.0
103 acth-independent macronodular adrenal hyperplasia 11.0
104 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 11.0
105 achalasia-addisonianism-alacrima syndrome 11.0
106 glycogen storage disease ia 11.0
107 growth hormone insensitivity with immunodeficiency 11.0
108 diarrhea 2, with microvillus atrophy 11.0
109 bruck syndrome 1 11.0
110 parana hard-skin syndrome 11.0
111 rothmund-thomson syndrome, type 2 11.0
112 spondyloepimetaphyseal dysplasia, sponastrime type 11.0
113 dyskeratosis congenita, x-linked 11.0
114 kallmann syndrome with spastic paraplegia 11.0
115 stuve-wiedemann syndrome 11.0
116 pigmented nodular adrenocortical disease, primary, 2 11.0
117 pigmented nodular adrenocortical disease, primary, 1 11.0
118 osteogenesis imperfecta, type viii 11.0
119 candidiasis, familial, 6 11.0
120 dyskeratosis congenita, autosomal recessive 2 11.0
121 dyskeratosis congenita, autosomal recessive 3 11.0
122 dyskeratosis congenita, autosomal dominant 3 11.0
123 pigmented nodular adrenocortical disease, primary, 3 11.0
124 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 11.0
125 estrogen resistance 11.0
126 acth-independent macronodular adrenal hyperplasia 2 11.0
127 analbuminemia 11.0
128 dyskeratosis congenita, autosomal recessive 6 11.0
129 thrombocytopenia 6 11.0
130 ovarian dysgenesis 8 11.0
131 primary pigmented nodular adrenocortical disease 11.0
132 46 xy gonadal dysgenesis 11.0
133 atypical werner syndrome 11.0
134 neonatal adrenoleukodystrophy 11.0
135 singleton-merten syndrome 11.0
136 idiopathic infantile hypercalcemia 11.0
137 pelvic organ prolapse 11.0 ESR1 COL1A2 COL1A1
138 osteogenesis imperfecta, type iv 10.9 WNT1 COL1A2 COL1A1
139 bone mineral density quantitative trait locus 3 10.9
140 ehlers-danlos/osteogenesis imperfecta syndrome 10.9 COL1A2 COL1A1
141 arthrochalasia ehlers-danlos syndrome 10.9 COL1A2 COL1A1
142 high bone mass osteogenesis imperfecta 10.9 COL1A2 COL1A1
143 larsen-like syndrome 10.9 COL1A2 COL1A1
144 type i ehlers-danlos syndrome 10.9 COL1A2 COL1A1
145 fibrogenesis imperfecta ossium 10.9 COL1A2 COL1A1
146 classic ehlers-danlos syndrome 10.8 COL1A2 COL1A1
147 gliofibroma 10.8 COL1A2 COL1A1
148 osteoarthritis 10.8
149 osteogenesis imperfecta, type vi 10.8 COL1A2 COL1A1
150 osteonecrosis 10.8
151 hypogonadism 10.8
152 hypogonadotropism 10.8
153 osteomalacia 10.8
154 diffuse scleroderma 10.8 COL1A2 COL1A1
155 back pain 10.7
156 osteogenesis imperfecta, type vii 10.7 COL1A2 COL1A1
157 osteonecrosis of the jaw 10.7
158 rheumatoid arthritis 10.7
159 x-linked alport syndrome 10.6 COL1A2 COL1A1
160 secondary hyperparathyroidism 10.6
161 arthritis 10.6
162 mammary paget's disease 10.6
163 triiodothyronine receptor auxiliary protein 10.6
164 primary hyperparathyroidism 10.6
165 inflammatory bowel disease 10.6
166 hyperthyroidism 10.6
167 diabetes mellitus 10.6
168 cole-carpenter syndrome 10.5 COL1A2 COL1A1
169 periodontitis 10.5
170 body mass index quantitative trait locus 1 10.5
171 amenorrhea 10.5
172 pulmonary disease, chronic obstructive 10.5
173 inflammatory spondylopathy 10.5
174 spondylitis 10.5
175 chronic kidney disease 10.5
176 spondyloarthropathy 1 10.5
177 thalassemia 10.5
178 spinal cord injury 10.5
179 insulin-like growth factor i 10.4
180 mastocytosis 10.4
181 liver disease 10.4
182 aging 10.4
183 liver cirrhosis 10.4
184 alcohol use disorder 10.4
185 arterial calcification, generalized, of infancy, 1 10.4
186 prostate cancer 10.4
187 kidney disease 10.4
188 avascular necrosis 10.4
189 endometrial cancer 10.4
190 primary biliary cirrhosis 10.4
191 alcohol dependence 10.4
192 myeloma, multiple 10.4
193 autoimmune disease 10.4
194 rheumatic disease 10.4
195 chronic pain 10.4
196 crohn's disease 10.4
197 atherosclerosis susceptibility 10.3
198 hypothyroidism 10.3
199 lipid metabolism disorder 10.3
200 osteogenic sarcoma 10.3
201 arthropathy 10.3
202 breast cancer 10.3
203 nephrolithiasis, calcium oxalate 10.3
204 body mass index quantitative trait locus 11 10.3
205 paget's disease of bone 10.3
206 lung disease 10.3
207 cystic fibrosis 10.3
208 body mass index quantitative trait locus 9 10.3
209 body mass index quantitative trait locus 8 10.3
210 body mass index quantitative trait locus 4 10.3
211 body mass index quantitative trait locus 10 10.3
212 body mass index quantitative trait locus 7 10.3
213 body mass index quantitative trait locus 12 10.3
214 body mass index quantitative trait locus 14 10.3
215 body mass index quantitative trait locus 18 10.3
216 body mass index quantitative trait locus 19 10.3
217 body mass index quantitative trait locus 20 10.3
218 systemic lupus erythematosus 10.3
219 graves disease 1 10.3
220 beta-thalassemia 10.3
221 renal osteodystrophy 10.3
222 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
223 hemosiderosis 10.3
224 47,xyy 10.3
225 rare hereditary hemochromatosis 10.3
226 lupus erythematosus 10.3
227 yemenite deaf-blind hypopigmentation syndrome 10.2
228 hydrops, lactic acidosis, and sideroblastic anemia 10.2
229 synovitis 10.2
230 hyperglycemia 10.2
231 coronary heart disease 1 10.2
232 endometrial hyperplasia 10.2
233 fibrosis of extraocular muscles, congenital, 1 10.2
234 vascular disease 10.2
235 paraplegia 10.2
236 connective tissue disease 10.2
237 endosteal hyperostosis, autosomal dominant 10.2
238 temporal arteritis 10.2
239 autosomal recessive disease 10.2
240 premature menopause 10.2
241 muscular dystrophy 10.2
242 rapidly involuting congenital hemangioma 10.2
243 lactose intolerance 10.2
244 cholestasis 10.2
245 cerebral palsy 10.2
246 acromegaly 10.2
247 cerebrovascular disease 10.2
248 peptic ulcer disease 10.2
249 depression 10.2
250 hyperprolactinemia 10.2
251 lymphocytic leukemia 10.2
252 urticaria 10.2
253 enthesopathy 10.2
254 acroosteolysis 10.2
255 hypercholesterolemia, familial, 1 10.2
256 spondylolisthesis 10.2
257 hypogonadism, male 10.2
258 osteomyelitis 10.2
259 hypoparathyroidism 10.2
260 vitamin k deficiency bleeding 10.2
261 heart disease 10.2
262 esophagitis 10.2
263 algoneurodystrophy 10.2
264 muscular atrophy 10.2
265 gastrointestinal system disease 10.2
266 ulcerative colitis 10.2
267 reflex sympathetic dystrophy 10.1
268 leukemia, acute lymphoblastic 10.1
269 hyperostosis 10.1
270 gastritis 10.1
271 juvenile rheumatoid arthritis 10.1
272 cataract 10.1
273 48,xyyy 10.1
274 pik3ca-related overgrowth syndrome 10.1
275 dermatomyositis 10.1
276 spondylosis 10.1
277 dermatitis 10.1
278 bone inflammation disease 10.1
279 pemphigus 10.1
280 growth hormone deficiency 10.1
281 idiopathic hypercalciuria 10.1
282 thyroid carcinoma 10.1
283 multiple sclerosis 10.1
284 muscular dystrophy, duchenne type 10.1
285 psoriatic arthritis 10.1
286 benign paroxysmal positional nystagmus 10.1
287 constipation 10.1
288 arteriosclerosis 10.1
289 congestive heart failure 10.1
290 rare disease in surgical orthopedic 10.1
291 gastroesophageal reflux 10.1
292 mastocytosis, cutaneous 10.1
293 homocysteinemia 10.1
294 deficiency anemia 10.1
295 hyperphosphatemia 10.1
296 hemiplegia 10.1
297 conn's syndrome 10.1
298 myopathy 10.1
299 degenerative disc disease 10.1
300 alzheimer disease 10.1
301 periodontitis, chronic 10.1
302 uveitis 10.1
303 gout 10.1
304 impotence 10.1
305 ankylosis 10.1
306 pustulosis of palm and sole 10.1
307 adenoma 10.1
308 psoriasis 10.1
309 hypopituitarism 10.1
310 dysphagia 10.1
311 esophageal cancer 10.1
312 sarcoidosis 1 10.1
313 schizophrenia 10.1
314 hemochromatosis, type 1 10.1
315 asthma 10.1
316 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
317 peripheral vascular disease 10.1
318 hypophosphatemia 10.1
319 gingival recession 10.1
320 neutropenia 10.1
321 leukemia 10.1
322 nephrocalcinosis 10.1
323 diarrhea 10.1
324 renal tubular acidosis 10.1
325 hyperinsulinism 10.1
326 iron metabolism disease 10.1
327 complex regional pain syndrome 10.1
328 cellulitis 10.1
329 skin disease 10.1
330 end stage renal failure 10.1
331 fatty liver disease 10.1
332 cytokine deficiency 10.1
333 arteries, anomalies of 10.0
334 colorectal cancer 10.0
335 helicobacter pylori infection 10.0
336 stroke, ischemic 10.0
337 pitt-hopkins syndrome 10.0
338 metabolic acidosis 10.0
339 fibrous dysplasia 10.0
340 non-alcoholic fatty liver disease 10.0
341 hyperuricemia 10.0
342 dental caries 10.0
343 bronchitis 10.0
344 vasculitis 10.0
345 cholangitis 10.0
346 bronchiectasis 10.0
347 neurofibromatosis, type iv, of riccardi 10.0
348 hypoascorbemia 10.0
349 creatinine clearance quantitative trait locus 10.0
350 gastric cancer 10.0
351 leukemia, acute lymphoblastic 3 10.0
352 exanthem 10.0
353 sleep apnea 10.0
354 atrial fibrillation 10.0
355 childhood acute lymphocytic leukemia 10.0
356 respiratory failure 10.0
357 nephrotic syndrome 10.0
358 dementia 10.0
359 gonadal dysgenesis 10.0
360 exostosis 10.0
361 idiopathic interstitial pneumonia 10.0
362 osteitis fibrosa 10.0
363 pulmonary fibrosis 10.0
364 rhinitis 10.0
365 indolent systemic mastocytosis 10.0
366 spinal stenosis 10.0
367 collagen disease 10.0
368 hemophilia 10.0
369 premature aging 10.0
370 pemphigus vulgaris, familial 10.0
371 down syndrome 10.0
372 myasthenia gravis 10.0
373 alacrima, achalasia, and mental retardation syndrome 10.0
374 hyperlipoproteinemia, type iii 10.0
375 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
376 colitis 10.0
377 idiopathic scoliosis 10.0
378 siderosis 10.0
379 coronary artery anomaly 10.0
380 allergic hypersensitivity disease 10.0
381 goiter 10.0
382 ehlers-danlos syndrome 10.0
383 calcinosis 10.0
384 hepatitis c 10.0
385 endometriosis 10.0
386 systemic scleroderma 10.0
387 poliomyelitis 10.0
388 fibromyalgia 10.0
389 monoclonal gammopathy of uncertain significance 10.0
390 septic arthritis 10.0
391 diabetes mellitus, noninsulin-dependent 9.9
392 retinal detachment 9.9
393 leprosy 3 9.9
394 proteasome-associated autoinflammatory syndrome 1 9.9
395 pycnodysostosis 9.9
396 bulimia nervosa 9.9
397 myocardial infarction 9.9
398 hepatitis c virus 9.9
399 sexual disorder 9.9
400 estrogen-receptor positive breast cancer 9.9
401 spondyloarthropathy 9.9
402 polycystic ovary syndrome 9.9
403 iron deficiency anemia 9.9
404 thrombocytopenia 9.9
405 epilepsy 9.9
406 epidermolysis bullosa 9.9
407 plasmacytoma 9.9
408 thyroid gland disease 9.9
409 intestinal disease 9.9
410 parathyroid adenoma 9.9
411 neuropathy 9.9
412 pulmonary embolism 9.9
413 irritable bowel syndrome 9.9
414 alopecia 9.9
415 hypoglycemia 9.9
416 hansen's disease 9.9
417 polymyositis 9.9
418 differentiated thyroid carcinoma 9.9
419 rare surgical neurologic disease 9.9
420 hepatocellular carcinoma 9.9
421 hypertriglyceridemia, familial 9.9
422 migraine with or without aura 1 9.9
423 myositis 9.9
424 osteogenesis imperfecta, type i 9.9
425 pernicious anemia 9.9
426 scheuermann disease 9.9
427 trichorhinophalangeal syndrome, type i 9.9
428 lipoid congenital adrenal hyperplasia 9.9
429 hypophosphatemic rickets, x-linked recessive 9.9
430 ataxia and polyneuropathy, adult-onset 9.9
431 pituitary adenoma, prolactin-secreting 9.9
432 xanthomatosis 9.9
433 dermatitis, atopic 9.9
434 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
435 microvascular complications of diabetes 3 9.9
436 microvascular complications of diabetes 4 9.9
437 microvascular complications of diabetes 6 9.9
438 microvascular complications of diabetes 7 9.9
439 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.9
440 peripheral artery disease 9.9
441 lymphoma 9.9
442 crohn's colitis 9.9
443 infant gynecomastia 9.9
444 gynecomastia 9.9
445 peptic esophagitis 9.9
446 childhood type dermatomyositis 9.9
447 mental depression 9.9
448 substance abuse 9.9
449 acute kidney failure 9.9
450 gingivitis 9.9
451 skin carcinoma 9.9
452 radiculopathy 9.9
453 neuromuscular disease 9.9
454 hypokalemia 9.9
455 epidermolysis bullosa dystrophica 9.9
456 pancreatitis 9.9
457 infertility 9.9
458 sleep disorder 9.9
459 peripheral nervous system disease 9.9
460 lymphopenia 9.9
461 herpes zoster 9.9
462 pulmonary emphysema 9.9
463 hemophilic arthropathy 9.9
464 splenomegaly 9.9
465 brain injury 9.9
466 hypotonia 9.9
467 hypoxia 9.9
468 spasticity 9.9
469 systemic autoimmune disease 9.9
470 overgrowth syndrome 9.9
471 corneal dystrophy, epithelial basement membrane 9.8
472 neurofibromatosis, type i 9.8
473 mccune-albright syndrome 9.8
474 hutchinson-gilford progeria syndrome 9.8
475 neural tube defects 9.8
476 spondylosis, cervical 9.8
477 thrombophilia due to thrombin defect 9.8
478 persistent hyperplastic primary vitreous, autosomal recessive 9.8
479 immune deficiency disease 9.8
480 mend syndrome 9.8
481 arts syndrome 9.8
482 rett syndrome 9.8
483 allergic rhinitis 9.8
484 major depressive disorder 9.8
485 major affective disorder 8 9.8
486 major affective disorder 9 9.8
487 premature ovarian failure 7 9.8
488 non-alcoholic steatohepatitis 9.8
489 sensorineural hearing loss 9.8
490 nasopharyngitis 9.8
491 gastric ulcer 9.8
492 prostatic hypertrophy 9.8
493 quadriplegia 9.8
494 cardiovascular system disease 9.8
495 exocrine pancreatic insufficiency 9.8
496 sclerosing cholangitis 9.8
497 primary hypertrophic osteoarthropathy 9.8
498 candidiasis 9.8
499 viral hepatitis 9.8
500 hepatitis b 9.8
501 autoimmune hepatitis 9.8
502 psychotic disorder 9.8
503 hemoglobinopathy 9.8
504 prostatic adenoma 9.8
505 acute pancreatitis 9.8
506 adenocarcinoma 9.8
507 testicular cancer 9.8
508 interstitial lung disease 9.8
509 bipolar disorder 9.8
510 mood disorder 9.8
511 purpura 9.8
512 pituitary adenoma 9.8
513 milk allergy 9.8
514 adrenal adenoma 9.8
515 bullous pemphigoid 9.8
516 atrophic gastritis 9.8
517 amyloidosis 9.8
518 meningitis 9.8
519 hypervitaminosis d 9.8
520 trichorhinophalangeal syndrome 9.8
521 aminoaciduria 9.8
522 distal renal tubular acidosis 9.8
523 oncogenic osteomalacia 9.8
524 age-related hearing loss 9.8
525 autonomic dysfunction 9.8
526 syncope 9.8
527 traumatic brain injury 9.8
528 inflammatory myopathy with abundant macrophages 9.8
529 vitreoretinopathy 9.8
530 amyotrophic lateral sclerosis 1 9.7
531 bladder cancer 9.7
532 multiple endocrine neoplasia, type i 9.7
533 exostoses, multiple, type i 9.7
534 hand skill, relative 9.7
535 hernia, hiatus 9.7
536 hypercalciuria, absorptive, 2 9.7
537 hypercalcemia, infantile, 1 9.7
538 hyperostosis frontalis interna 9.7
539 hypertension, essential 9.7
540 inclusion body myositis 9.7
541 marfan syndrome 9.7
542 ovarian cancer 9.7
543 polykaryocytosis inducer 9.7
544 prader-willi syndrome 9.7
545 pulmonary fibrosis, idiopathic 9.7
546 scoliosis, isolated 1 9.7
547 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 9.7
548 diabetes mellitus, insulin-dependent 9.7
549 gaucher disease, type i 9.7
550 hypervitaminosis a 9.7
551 familial mediterranean fever 9.7
552 shwachman-diamond syndrome 1 9.7
553 pituitary hormone deficiency, combined, 2 9.7
554 sjogren syndrome 9.7
555 hypothyroidism, congenital, nongoitrous, 4 9.7
556 fabry disease 9.7
557 taqi polymorphism 9.7
558 prostatic hyperplasia, benign 9.7
559 macular degeneration, age-related, 1 9.7
560 sickle cell anemia 9.7
561 langerhans cell histiocytosis 9.7
562 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.7
563 huntington disease-like 2 9.7
564 anxiety 9.7
565 prostate cancer, hereditary, 4 9.7
566 intraocular pressure quantitative trait locus 9.7
567 lung cancer susceptibility 3 9.7
568 microvascular complications of diabetes 5 9.7
569 fatty liver disease, nonalcoholic 1 9.7
570 graft-versus-host disease 9.7
571 bone mineral density quantitative trait locus 17 9.7
572 pulmonary hypertension 9.7
573 chlamydia pneumonia 9.7
574 brachydactyly 9.7
575 female breast cancer 9.7
576 vitamin b12 deficiency 9.7
577 progesterone-receptor positive breast cancer 9.7
578 pain agnosia 9.7
579 myelomeningocele 9.7
580 recessive dystrophic epidermolysis bullosa 9.7
581 stickler syndrome 9.7
582 silicosis 9.7
583 pre-eclampsia 9.7
584 glucose intolerance 9.7
585 short bowel syndrome 9.7
586 fanconi syndrome 9.7
587 microphthalmia 9.7
588 renal hypertension 9.7
589 portal hypertension 9.7
590 hydrocephalus 9.7
591 cholesteatoma of middle ear 9.7
592 ovarian disease 9.7
593 hydronephrosis 9.7
594 sarcoma 9.7
595 chlamydia 9.7
596 blind hypotensive eye 9.7
597 visual epilepsy 9.7
598 low compliance bladder 9.7
599 secondary hyperparathyroidism of renal origin 9.7
600 acute leukemia 9.7
601 guillain-barre syndrome 9.7
602 dental fluorosis 9.7
603 hypophosphatasia 9.7
604 adult-onset still's disease 9.7
605 46 xx gonadal dysgenesis 9.7
606 gingival disease 9.7
607 angioedema 9.7
608 ectropion 9.7
609 endogenous depression 9.7
610 lymphadenitis 9.7
611 pneumothorax 9.7
612 cystitis 9.7
613 ichthyosis 9.7
614 duodenal ulcer 9.7
615 neuritis 9.7
616 gaucher's disease 9.7
617 vaginitis 9.7
618 lateral sclerosis 9.7
619 hemangioma 9.7
620 glomerulonephritis 9.7
621 antiphospholipid syndrome 9.7
622 lipomatosis 9.7
623 inappropriate adh syndrome 9.7
624 histiocytosis 9.7
625 mixed connective tissue disease 9.7
626 empty sella syndrome 9.7
627 gastric adenocarcinoma 9.7
628 anovulation 9.7
629 craniopharyngioma 9.7
630 thrombophlebitis 9.7
631 pseudohypoparathyroidism 9.7
632 glucose metabolism disease 9.7
633 spindle cell sarcoma 9.7
634 atrophic rhinitis 9.7
635 human immunodeficiency virus infectious disease 9.7
636 severe combined immunodeficiency 9.7
637 acquired immunodeficiency syndrome 9.7
638 diffuse idiopathic skeletal hyperostosis 9.7
639 compartment syndrome 9.7
640 b-cell lymphoma 9.7
641 osteochondrosis 9.7
642 duodenitis 9.7
643 subacute delirium 9.7
644 myeloid leukemia 9.7
645 intermediate coronary syndrome 9.7
646 hard palate cancer 9.7
647 achalasia 9.7
648 postpartum depression 9.7
649 diabetic neuropathy 9.7
650 dystrophinopathies 9.7
651 satb2-associated syndrome 9.7
652 sickle cell disease 9.7
653 chronic graft versus host disease 9.7
654 glioma 9.7
655 secondary adrenal insufficiency 9.7
656 skeletal dysplasias 9.7
657 spondylarthropathy 9.7
658 stevens-johnson syndrome/toxic epidermal necrolysis 9.7
659 tuberculous meningitis 9.7
660 multiple endocrine neoplasia 9.7
661 pituitary tumors 9.7
662 postherpetic neuralgia 9.7
663 seizure disorder 9.7
664 glial tumor 9.7
665 progeroid syndrome 9.7
666 glomerular disease 9.7
667 undetermined colitis 9.7
668 neurofibromatosis, type ii 9.6
669 pseudohypoparathyroidism, type ia 9.6
670 angelman syndrome 9.6
671 epidermolytic hyperkeratosis 9.6
672 burkitt lymphoma 9.6
673 arthrogryposis, distal, type 3 9.6
674 cardiac arrhythmia 9.6
675 carpal tunnel syndrome 9.6
676 leukocyte adhesion deficiency, type i 9.6
677 chiari malformation type i 9.6
678 coloboma of macula 9.6
679 exostoses, multiple, type ii 9.6
680 exudative vitreoretinopathy 1 9.6
681 factor viii deficiency 9.6
682 fibrodysplasia ossificans progressiva 9.6
683 hair whorl 9.6
684 renal cell carcinoma, nonpapillary 9.6
685 hypogonadotropic hypogonadism 7 with or without anosmia 9.6
686 multiple system atrophy 1 9.6
687 ichthyosis vulgaris 9.6
688 hyper-ige recurrent infection syndrome 1, autosomal dominant 9.6
689 jacobsen syndrome 9.6
690 leukemia, chronic lymphocytic 9.6
691 lipomatosis, multiple symmetric 9.6
692 moebius syndrome 9.6
693 facioscapulohumeral muscular dystrophy 1 9.6
694 myelopathy, htlv-1-associated 9.6
695 oculopharyngeal muscular dystrophy 9.6
696 gnathodiaphyseal dysplasia 9.6
697 otitis media 9.6
698 papillomatosis, confluent and reticulated 9.6
699 parkinson disease, late-onset 9.6
700 pheochromocytoma 9.6
701 pityriasis rubra pilaris 9.6
702 protoporphyria, erythropoietic, 1 9.6
703 pulmonary hypertension, primary, 1 9.6
704 dowling-degos disease 1 9.6
705 retinoblastoma 9.6
706 schistosoma mansoni infection, susceptibility/ 9.6
707 spondyloepimetaphyseal dysplasia, strudwick type 9.6
708 syringomyelia, noncommunicating isolated 9.6
709 thrombophilia due to activated protein c resistance 9.6
710 thyroid cancer, nonmedullary, 1 9.6
711 tobacco addiction 9.6
712 trigeminal neuralgia 9.6
713 tuberous sclerosis 1 9.6
714 urate oxidase, pseudogene 9.6
715 varicose veins 9.6
716 vitreoretinopathy, neovascular inflammatory 9.6
717 von hippel-lindau syndrome 9.6
718 neuropathy, hereditary sensory and autonomic, type iia 9.6
719 arachnoid cysts, intracranial 9.6
720 lung cancer 9.6
721 craniodiaphyseal dysplasia 9.6
722 neuropathy, hereditary sensory and autonomic, type iii 9.6
723 enterocolitis 9.6
724 galactorrhea 9.6
725 glycogen storage disease ii 9.6
726 renal glucosuria 9.6
727 ovarian dysgenesis 1 9.6
728 lymphoma, hodgkin, classic 9.6
729 hutterite cerebroosteonephrodysplasia syndrome 9.6
730 mckusick-kaufman syndrome 9.6
731 chylomicron retention disease 9.6
732 muscular dystrophy, limb-girdle, autosomal recessive 2 9.6
733 myelofibrosis 9.6
734 gyrate atrophy of choroid and retina 9.6
735 osteoid osteoma 9.6
736 osteopetrosis, autosomal recessive 1 9.6
737 pancreatic cancer 9.6
738 laron syndrome 9.6
739 taurodontism 9.6
740 mayer-rokitansky-kuster-hauser syndrome 9.6
741 spondylocostal dysostosis 1, autosomal recessive 9.6
742 xeroderma pigmentosum, variant type 9.6
743 alopecia, congenital 9.6
744 coats disease 9.6
745 hemophilia a 9.6
746 hemophilia b 9.6
747 lowe oculocerebrorenal syndrome 9.6
748 norrie disease 9.6
749 kearns-sayre syndrome 9.6
750 oncocytoma 9.6
751 deafness, aminoglycoside-induced 9.6
752 gonadal agenesis 9.6
753 gallbladder disease 1 9.6
754 transsexuality 9.6
755 suppression of tumorigenicity 12 9.6
756 hypocalcemia, autosomal dominant 1 9.6
757 dental anomalies and short stature 9.6
758 dermatitis herpetiformis, familial 9.6
759 leukemia, acute myeloid 9.6
760 bone mineral density quantitative trait locus 1 9.6
761 hemochromatosis, type 2a 9.6
762 ossification of the posterior longitudinal ligament of spine 9.6
763 cervical cancer 9.6
764 chudley-mccullough syndrome 9.6
765 aceruloplasminemia 9.6
766 orthostatic intolerance 9.6
767 huntington disease-like 3 9.6
768 lymphoma, non-hodgkin, familial 9.6
769 paragangliomas 3 9.6
770 late-onset retinal degeneration 9.6
771 bone mineral density quantitative trait locus 2 9.6
772 genitopatellar syndrome 9.6
773 muscular dystrophy-dystroglycanopathy , type c, 5 9.6
774 epileptic encephalopathy, early infantile, 6 9.6
775 carotid intimal medial thickness 2 9.6
776 severe cutaneous adverse reaction 9.6
777 leukoencephalopathy, arthritis, colitis, and hypogammaglobulinema 9.6
778 carney complex variant 9.6
779 aplastic anemia 9.6
780 mevalonic aciduria 9.6
781 asthma-related traits 4 9.6
782 bone mineral density quantitative trait locus 7 9.6
783 glass syndrome 9.6
784 hypophosphatemic rickets, autosomal recessive, 2 9.6
785 alpha-1-antitrypsin deficiency 9.6
786 complement component 3 deficiency, autosomal recessive 9.6
787 microcephaly, epilepsy, and diabetes syndrome 9.6
788 myelodysplastic syndrome 9.6
789 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.6
790 leptin deficiency or dysfunction 9.6
791 leptin receptor deficiency 9.6
792 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.6
793 osteogenesis imperfecta, type xv 9.6
794 seizures, scoliosis, and macrocephaly/microcephaly syndrome 9.6
795 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.6
796 hyperparathyroidism 4 9.6
797 helix syndrome 9.6
798 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.6
799 angina pectoris 9.6
800 tendinitis 9.6
801 tendinosis 9.6
802 kashin-beck disease 9.6
803 erythema multiforme 9.6
804 loeys-dietz syndrome 9.6
805 variola major 9.6
806 congenital generalized lipodystrophy 9.6
807 arterial calcification of infancy 9.6
808 paraganglioma 9.6
809 limb ischemia 9.6
810 colorectal adenoma 9.6
811 fibroma 9.6
812 adrenal gland pheochromocytoma 9.6
813 autosomal recessive hypophosphatemic rickets 9.6
814 autism spectrum disorder 9.6
815 paraphilia disorder 9.6
816 alexithymia 9.6
817 microscopic colitis 9.6
818 ileitis 9.6
819 persistent hyperplastic primary vitreous 9.6
820 parietal foramina 9.6
821 pollen allergy 9.6
822 drug allergy 9.6
823 autosomal recessive congenital ichthyosis 9.6
824 muscular disease 9.6
825 acromesomelic dysplasia 9.6
826 superior semicircular canal dehiscence 9.6
827 nodal marginal zone lymphoma 9.6
828 hemochromatosis type 2 9.6
829 corneal disease 9.6
830 dry eye syndrome 9.6
831 cholelithiasis 9.6
832 tuberculoid leprosy 9.6
833 pneumoconiosis 9.6
834 anthracosis 9.6
835 yaws 9.6
836 bacterial infectious disease 9.6
837 protein-losing enteropathy 9.6
838 open-angle glaucoma 9.6
839 chronic pyelonephritis 9.6
840 chronic frontal sinusitis 9.6
841 frontal sinusitis 9.6
842 lepromatous leprosy 9.6
843 microcephaly 9.6
844 transsexualism 9.6
845 intracranial aneurysm 9.6
846 lipoid nephrosis 9.6
847 discitis 9.6
848 pulpitis 9.6
849 allergic conjunctivitis 9.6
850 erysipelas 9.6
851 tetanus 9.6
852 bladder calculus 9.6
853 pyelonephritis 9.6
854 diphtheria 9.6
855 horner's syndrome 9.6
856 autonomic neuropathy 9.6
857 chondrocalcinosis 9.6
858 hyperandrogenism 9.6
859 palindromic rheumatism 9.6
860 protein-energy malnutrition 9.6
861 postmenopausal atrophic vaginitis 9.6
862 neurogenic bladder 9.6
863 common variable immunodeficiency 9.6
864 oligohydramnios 9.6
865 cartilage disease 9.6
866 spinal muscular atrophy 9.6
867 tarsal tunnel syndrome 9.6
868 vestibular neuronitis 9.6
869 locked-in syndrome 9.6
870 leiomyoma 9.6
871 sialolithiasis 9.6
872 scleritis 9.6
873 tuberous sclerosis 9.6
874 eclampsia 9.6
875 patent foramen ovale 9.6
876 sick sinus syndrome 9.6
877 polyneuropathy 9.6
878 schistosomiasis 9.6
879 iritis 9.6
880 toxic shock syndrome 9.6
881 frozen shoulder 9.6
882 ochronosis 9.6
883 shoulder impingement syndrome 9.6
884 labyrinthitis 9.6
885 cholera 9.6
886 avoidant personality disorder 9.6
887 personality disorder 9.6
888 normal pressure hydrocephalus 9.6
889 thrombocytopenia due to platelet alloimmunization 9.6
890 keratosis 9.6
891 ventricular septal defect 9.6
892 heart septal defect 9.6
893 neuroendocrine tumor 9.6
894 mitral valve stenosis 9.6
895 thyroid gland cancer 9.6
896 giant cell tumor 9.6
897 neuroma 9.6
898 encephalomalacia 9.6
899 post-traumatic stress disorder 9.6
900 hereditary multiple exostoses 9.6
901 essential thrombocythemia 9.6
902 myeloproliferative neoplasm 9.6
903 thrombocytosis 9.6
904 hepatitis 9.6
905 gastroenteritis 9.6
906 generalized atherosclerosis 9.6
907 hyperpituitarism 9.6
908 basal cell carcinoma 9.6
909 orchitis 9.6
910 testicular disease 9.6
911 agammaglobulinemia 9.6
912 kidney cancer 9.6
913 myoma 9.6
914 bilirubin metabolic disorder 9.6
915 auditory system disease 9.6
916 glycogen storage disease 9.6
917 nonspecific interstitial pneumonia 9.6
918 bruxism 9.6
919 severe acute respiratory syndrome 9.6
920 pulmonary tuberculosis 9.6
921 bursitis 9.6
922 cystic kidney disease 9.6
923 papillary carcinoma 9.6
924 cutis laxa 9.6
925 skin squamous cell carcinoma 9.6
926 tropical spastic paraparesis 9.6
927 lysosomal storage disease 9.6
928 demyelinating disease 9.6
929 myelitis 9.6
930 causalgia 9.6
931 lipid pneumonia 9.6
932 central nervous system disease 9.6
933 bacterial vaginosis 9.6
934 palmoplantar keratosis 9.6
935 breast disease 9.6
936 plague 9.6
937 necrobiosis lipoidica 9.6
938 chronic wasting disease 9.6
939 superior mesenteric artery syndrome 9.6
940 olfactory neuroblastoma 9.6
941 leukorrhea 9.6
942 vaginal discharge 9.6
943 lung squamous cell carcinoma 9.6
944 thyroid gland papillary carcinoma 9.6
945 dentinogenesis imperfecta 9.6
946 intracranial thrombosis 9.6
947 hypertrichosis 9.6
948 carcinosarcoma 9.6
949 polyradiculoneuropathy 9.6
950 seminoma 9.6
951 macular retinal edema 9.6
952 bartter disease 9.6
953 pseudohypoaldosteronism 9.6
954 persian gulf syndrome 9.6
955 hypotrichosis 9.6
956 familial retinoblastoma 9.6
957 uremia 9.6
958 calciphylaxis 9.6
959 aggressive systemic mastocytosis 9.6
960 movement disease 9.6
961 eunuchism 9.6
962 ovarian cyst 9.6
963 chronic inflammatory demyelinating polyradiculoneuropathy 9.6
964 eye disease 9.6
965 adenosine deaminase deficiency 9.6
966 hemolytic anemia 9.6
967 brown-sequard syndrome 9.6
968 acute stress disorder 9.6
969 epithelioid sarcoma 9.6
970 conjunctivitis 9.6
971 reactive arthritis 9.6
972 renal oncocytoma 9.6
973 combined t cell and b cell immunodeficiency 9.6
974 plasma cell neoplasm 9.6
975 inherited metabolic disorder 9.6
976 kummell's disease 9.6
977 myositis ossificans 9.6
978 mitochondrial metabolism disease 9.6
979 premenstrual tension 9.6
980 active peptic ulcer disease 9.6
981 neuroblastoma 9.6
982 childhood leukemia 9.6
983 complement component 3 deficiency 9.6
984 retinal degeneration 9.6
985 localized scleroderma 9.6
986 dermatitis herpetiformis 9.6
987 nervous system disease 9.6
988 smallpox 9.6
989 fascioliasis 9.6
990 viral infectious disease 9.6
991 exophthalmos 9.6
992 iridocyclitis 9.6
993 acute myocardial infarction 9.6
994 diabetes insipidus 9.6
995 fasciitis 9.6
996 necrotizing fasciitis 9.6
997 pathologic nystagmus 9.6
998 tenosynovitis 9.6
999 peripheral vertigo 9.6
1000 alopecia areata 9.6
1001 hypereosinophilic syndrome 9.6
1002 myotonic dystrophy 9.6
1003 cleidocranial dysplasia spectrum disorder 9.6
1004 hypermobile ehlers-danlos syndrome 9.6
1005 isolated gonadotropin-releasing hormone deficiency 9.6
1006 juvenile hereditary hemochromatosis 9.6
1007 kat6b-related disorders 9.6
1008 mitochondrial disorders 9.6
1009 multiple epiphyseal dysplasia, recessive 9.6
1010 spondylocostal dysostosis, autosomal recessive 9.6
1011 allergic encephalomyelitis 9.6
1012 central congenital hypothyroidism 9.6
1013 chiari malformation 9.6
1014 chromosomal triplication 9.6
1015 chromosome 20p duplication 9.6
1016 dentinogenesis imperfecta type 2 9.6
1017 dwarfism 9.6
1018 epilepsy progressive myoclonic type 3 9.6
1019 germ cells tumors 9.6
1020 glossodynia 9.6
1021 heparin-induced thrombocytopenia 9.6
1022 homologous wasting disease 9.6
1023 htlv-1 associated myelopathy/tropical spastic paraparesis 9.6
1024 hyperadrenalism 9.6
1025 idiopathic neutropenia 9.6
1026 lathyrism 9.6
1027 lymphangiectasis 9.6
1028 medullary sponge kidney 9.6
1029 ovarian epithelial cancer 9.6
1030 precocious puberty 9.6
1031 primary intestinal lymphangiectasia 9.6
1032 pure autonomic failure 9.6
1033 pustular psoriasis 9.6
1034 slc4a1-associated distal renal tubular acidosis 9.6
1035 spastic paraparesis 9.6
1036 sudden sensorineural hearing loss 9.6
1037 synovial chondromatosis 9.6
1038 thrombasthenia 9.6
1039 transverse myelitis 9.6
1040 raynaud phenomenon 9.6
1041 bunion 9.6
1042 combined pituitary hormone deficiency 9.6
1043 cytomegalovirus infection 9.6
1044 dysautonomia 9.6
1045 headache 9.6
1046 posttransplant acute limbic encephalitis 9.6
1047 congenital hypogonadotropic hypogonadism 9.6
1048 cerebrofacial arteriovenous metameric syndrome 9.6
1049 familial calcium pyrophosphate deposition 9.6
1050 isolated bone marrow mastocytosis 9.6
1051 autosomal dominant epidermolytic ichthyosis 9.6
1052 autosomal recessive malignant osteopetrosis 9.6
1053 bone sarcoma 9.6
1054 amelia 9.6
1055 eosinophilic colitis 9.6
1056 traumatic avascular necrosis 9.6
1057 idiopathic avascular necrosis 9.6
1058 erythema multiforme major 9.6
1059 autoimmune hypoparathyroidism 9.6
1060 acute liver failure 9.6
1061 moderate and severe traumatic brain injury 9.6
1062 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.6
1063 acute adrenal insufficiency 9.6

Comorbidity relations with Osteoporosis via Phenotypic Disease Network (PDN): (showing 85, show less)


Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Alzheimer Disease
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Asthma
Benign Essential Hypertension Bronchiectasis
Bronchitis Bronchopneumonia
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Pulmonary Heart Disease
Chylomicron Retention Disease Conjunctivitis
Conn's Syndrome Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Dyskinesia of Esophagus
Dysthymic Disorder Esophagitis
Femoral Vein Thrombophlebitis Gastroesophageal Reflux
Generalized Anxiety Disorder Generalized Atherosclerosis
Heart Disease Hyperparathyroidism
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Idiopathic Interstitial Pneumonia
Inflammatory Bowel Disease 1 Intervertebral Disc Disease
Intestinal Obstruction Iron Deficiency Anemia
Irritable Bowel Syndrome Macular Degeneration, Age-Related, 1
Major Depressive Disorder Marasmus
Monoclonal Paraproteinemia Neurogenic Bladder
Nutritional Deficiency Disease Opioid Addiction
Oral Candidiasis Osteoarthritis
Osteoarthritis with Mild Chondrodysplasia Osteomalacia
Osteoporosis, Juvenile Paralytic Ileus
Paraplegia Parkinson Disease, Late-Onset
Pelvic Organ Prolapse Pernicious Anemia
Plasma Cell Neoplasm Polymyositis
Postinflammatory Pulmonary Fibrosis Postmenopausal Atrophic Vaginitis
Postsurgical Hypothyroidism Premature Ovarian Failure 7
Protein-Energy Malnutrition Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2
Pyelonephritis Respiratory Failure
Retinitis Pigmentosa and Erythrocytic Microcytosis Rheumatoid Arthritis
Rickets Scheuermann Disease
Schizophreniform Disorder Sideroblastic Anemia
Sjogren Syndrome Spinal Cord Disease
Spondyloarthropathy 1 Status Asthmaticus
Swallowing Disorders Systemic Lupus Erythematosus
Temporal Arteritis Thrombophilia Due to Thrombin Defect
Transient Cerebral Ischemia Venous Insufficiency
Vulvovaginal Candidiasis

Graphical network of the top 20 diseases related to Osteoporosis:



Diseases related to Osteoporosis

Symptoms & Phenotypes for Osteoporosis

Human phenotypes related to Osteoporosis:

31 (showing 1, show less)
# Description HPO Frequency HPO Source Accession
1 osteoporosis 31 HP:0000939

Symptoms via clinical synopsis from OMIM:

56
Skel:
postmenopausal osteoporosis

Clinical features from OMIM:

166710

UMLS symptoms related to Osteoporosis:


tremor, angina pectoris, back pain, sciatica, equilibration disorder, muscle cramp, pelvic pain

MGI Mouse Phenotypes related to Osteoporosis:

45 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 CALCR COL1A1 COL1A2 ESR1 LRP5 VDR

Drugs & Therapeutics for Osteoporosis

PubMed Health treatment related to Osteoporosis: 62

Even if someone already has osteoporosis , it is important for them to do regular exercise and get enough calcium and vitamin D . In Germany, statutory health insurances cover the cost of calcium or vitamin D supplements if a doctor has prescribed them. Osteoporosis can be treated with several drugs designed to slow bone loss and increase the production of new bone tissue . These include bisphosphonates and some hormonal or hormone -like medications. These kinds of drugs can have different types of side effects, though, and may not be suitable for everyone. They are only considered if someone has already broken a bone, or if their risk of bone fractures is high – for example, if their bone density is very low or if they have a combination of different risk factors, like low body weight, old age and a higher risk of falling . Hormone products, like those used to treat menopause symptoms , can also lower the risk of osteoporosis -related bone fractures when taken over the long term. But long-term hormone therapy during or after menopause increases the risk of cardiovascular diseases and breast cancer . For this reason it is only rarely recommended as treatment for osteoporosis. The pros and cons of this treatment should be carefully weighed.

Drugs for Osteoporosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 636, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linagliptin Approved Phase 4 668270-12-0 10096344
2
Dinoprostone Approved Phase 4 363-24-6 5280360
3
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
4
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
5
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Sodium citrate Approved, Investigational Phase 4 68-04-2
8
Tibolone Approved, Investigational Phase 4 5630-53-5
9
Potassium citrate Approved, Investigational, Vet_approved Phase 4
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Atorvastatin Approved Phase 4 134523-00-5 60823
12
Cinacalcet Approved Phase 4 226256-56-0 156419
13
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
14
Etanercept Approved, Investigational Phase 4 185243-69-0
15
Pamidronate Approved Phase 4 40391-99-9 4674
16
Montelukast Approved Phase 4 158966-92-8 5281040
17
Adalimumab Approved Phase 4 331731-18-1 16219006
18
Norethindrone Approved Phase 4 68-22-4 6230
19
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
20
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
21
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
22
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
23
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
24
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
25
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
26
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
27
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
28
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
29
Gliclazide Approved Phase 4 21187-98-4 3475
30
Basiliximab Approved, Investigational Phase 4 179045-86-4, 152923-56-3
31
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
32
Ribavirin Approved Phase 4 36791-04-5 37542
33
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
34
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
35
Liraglutide Approved Phase 4 204656-20-2 44147092
36
Azathioprine Approved Phase 4 446-86-6 2265
37
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
38
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
39
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
40
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
41
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446