MCID: OST097
MIFTS: 44

Osteoporotic Fracture

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

MalaCards integrated aliases for Osteoporotic Fracture:

Name: Osteoporotic Fracture 55
Osteoporotic Fractures 73

Classifications:



External Ids:

UMLS 73 C0521170

Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteoporosis and osteonecrosis. An important gene associated with Osteoporotic Fracture is LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include bone, breast and prostate, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 osteoporosis 30.6 COL1A1 ESR1 IL6 TNFRSF11B
2 osteonecrosis 29.7 MTHFR TNFRSF11B
3 bone resorption disease 29.6 COL1A1 ESR1 IL6 TNFRSF11B
4 bone disease 29.4 COL1A1 IL6 TNFRSF11B
5 chronic kidney failure 29.4 IL6 MTHFR TNFRSF11B
6 periodontal disease 29.3 IL6 TNFRSF11B
7 bone mineral density quantitative trait locus 18 11.8
8 osteoarthritis 10.5
9 rheumatoid arthritis 10.3
10 arthritis 10.3
11 bone mineral density quantitative trait locus 8 10.3
12 bone mineral density quantitative trait locus 15 10.3
13 breast cancer 10.2
14 diabetes mellitus 10.2
15 spinal cord injury 10.2
16 atrial fibrillation 10.2
17 diabetes mellitus, noninsulin-dependent 10.1
18 prostate cancer 10.1
19 macular degeneration, age-related, 1 10.1
20 bone mineral density quantitative trait locus 3 10.1
21 liver disease 10.1
22 pelvic organ prolapse 10.1 COL1A1 ESR1
23 sudden sensorineural hearing loss 10.0 IL6 MTHFR
24 collagen disease 10.0 COL1A1 IL6
25 endometrial disease 10.0 ESR1 IL6
26 vaginitis 10.0 ESR1 IL6
27 gastroschisis 10.0 IL6 MTHFR
28 ischemic heart disease 10.0 IL6 MTHFR
29 encephalomalacia 10.0 IL6 MTHFR
30 schizophrenia 10.0
31 insulin-like growth factor i 10.0
32 aging 10.0
33 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 10.0
34 body mass index quantitative trait locus 1 10.0
35 anorexia nervosa 10.0
36 pulmonary disease, chronic obstructive 10.0
37 hyperprolactinemia 10.0
38 hepatitis 10.0
39 nonalcoholic fatty liver disease 10.0
40 hyperparathyroidism 10.0
41 disease of mental health 10.0
42 impotence 10.0
43 hepatitis c 10.0
44 fatty liver disease 10.0
45 depression 10.0
46 postural hypotension 10.0
47 central retinal vein occlusion 10.0 IL6 MTHFR
48 retinal vein occlusion 10.0 IL6 MTHFR
49 retinal artery occlusion 10.0 IL6 MTHFR
50 hematopoietic stem cell transplantation 10.0 IL6 MTHFR

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

MGI Mouse Phenotypes related to Osteoporotic Fracture:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.99 COL1A1 ESR1 IL6 LGR4 MTHFR TNFRSF11B
2 cardiovascular system MP:0005385 9.95 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
3 cellular MP:0005384 9.93 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
4 immune system MP:0005387 9.89 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
5 integument MP:0010771 9.88 COL1A1 ESR1 IL6 LGR4 MTHFR
6 mortality/aging MP:0010768 9.88 COL1A1 ESR1 IL6 LGR4 MTHFR TNFRSF11B
7 adipose tissue MP:0005375 9.86 COL1A1 ESR1 IL6 LGR4
8 digestive/alimentary MP:0005381 9.83 COL1A1 ESR1 IL6 LGR4
9 liver/biliary system MP:0005370 9.83 COL1A1 ESR1 IL6 LGR4 MTHFR
10 nervous system MP:0003631 9.77 COL1A1 ESR1 IL6 LGR4 MTHFR
11 limbs/digits/tail MP:0005371 9.76 COL1A1 ESR1 MTHFR TNFRSF11B
12 no phenotypic analysis MP:0003012 9.62 COL1A1 ESR1 LGR4 MTHFR
13 renal/urinary system MP:0005367 9.56 COL1A1 ESR1 IL6 LGR4
14 reproductive system MP:0005389 9.55 COL1A1 ESR1 IL6 LGR4 MTHFR
15 skeleton MP:0005390 9.35 COL1A1 ESR1 IL6 MTHFR TNFRSF11B
16 vision/eye MP:0005391 8.92 COL1A1 IL6 LGR4 MTHFR

Drugs & Therapeutics for Osteoporotic Fracture

Search Clinical Trials , NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

41
Bone, Breast, Prostate, Testes, Liver, Heart, Spinal Cord

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 1263)
# Title Authors Year
1
Prospective risk of osteoporotic fractures in patients with advanced chronic obstructive pulmonary disease. ( 29661041 )
2019
2
Identifying Unmet Treatment Needs for Patients With Osteoporotic Fracture: Feasibility Study for an Electronic Clinical Surveillance System. ( 29691201 )
2018
3
MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression. ( 29786747 )
2018
4
Discrete particle model for cement infiltration within open-cell structures: Prevention of osteoporotic fracture. ( 29898001 )
2018
5
Hepatitis C virus infection and risk of osteoporotic fracture: A systematic review and meta-analysis. ( 29322660 )
2018
6
Validated computational framework for efficient systematic evaluation of osteoporotic fracture fixation in the proximal humerus. ( 29728330 )
2018
7
Therapist's practice patterns for subsequent fall/osteoporotic fracture prevention for patients with a distal radius fracture. ( 29705078 )
2018
8
Comments on Li et al.: Meta-analysis of hypertension and osteoporotic fracture risk in women and men. ( 28986611 )
2018
9
Prevalence and Associated Risk Factors of Sarcopenia in Female Patients with Osteoporotic Fracture. ( 29564307 )
2018
10
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29651509 )
2018
11
Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT. ( 29314261 )
2018
12
Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture. ( 29464358 )
2018
13
Higher dietary glycemic index and glycemic load values increase the risk of osteoporotic fracture in the PREvenciA^n con DIeta MEDiterrA!nea (PREDIMED)-Reus trial. ( 29746627 )
2018
14
Impact of a fracture liaison service on patient management after an osteoporotic fracture: the CHUV FLS. ( 29376552 )
2018
15
The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. ( 29304151 )
2018
16
Dual modulation of bone formation and resorption with zoledronic acid-loaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study. ( 29079514 )
2018
17
The analysis of MSTMOVCF (Multi-segment thoracolumbar mild osteoporotic fractures surgery or conservative treatment) based on ASTLOF (the assessment system of thoracolumbar osteoporotic fracture). ( 29844542 )
2018
18
Usefulness of the Trabecular Bone Score for assessing the risk of osteoporotic fracture. ( 29329765 )
2018
19
Association of gout with osteoporotic fractures. ( 29955945 )
2018
20
Development of a risk assessment tool for osteoporotic fracture prevention: A claims data approach. ( 29421456 )
2018
21
Anxa2 attenuates osteoblast growth and is associated with hip BMD and osteoporotic fracture in Chinese elderly. ( 29570731 )
2018
22
Treatment costs and cost drivers among osteoporotic fracture patients in Japan: a retrospective database analysis. ( 29696390 )
2018
23
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29067485 )
2018
24
Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing. ( 29216500 )
2018
25
The use of a femoral distractor in the presence of an intramedullary nail proximal to an osteoporotic fracture. ( 29543057 )
2018
26
Meta-analysis of hypertension and osteoporotic fracture risk in women and men: response to comments by RodrA-guez et al. ( 28986610 )
2018
27
Association of Bone Morphogenetic Protein (BMP)/Smad Signaling Pathway with Fracture Healing and Osteogenic Ability in Senile Osteoporotic Fracture in Humans and Rats. ( 29938690 )
2018
28
Characteristics of bone biochemical indices in predicting secondary osteoporotic fracture after intertrochanteric fracture in elderly women. ( 29662773 )
2018
29
Surgery for Multisegment Thoracolumbar Mild Osteoporotic Fractures: Revised Assessment System of Thoracolumbar Osteoporotic Fracture. ( 29588238 )
2018
30
Incidence and risk factors of medical complications and direct medical costs after osteoporotic fracture among patients in China. ( 29488018 )
2018
31
Association of Nonalcoholic Fatty Liver Disease With Osteoporotic Fractures: A Cross-Sectional Retrospective Study of Chinese Individuals. ( 30083134 )
2018
32
Chronic kidney disease, cardiovascular disease, and osteoporotic fractures in patients with and without HIV in the US Veteran's Affairs Administration System. ( 30378450 )
2018
33
Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women. ( 30171938 )
2018
34
High Plasma Sphingosine 1-phosphate Levels Predict Osteoporotic Fractures in Postmenopausal Women: The Center of Excellence for Osteoporosis Research Study. ( 29900158 )
2018
35
Prevention and management of osteoporosis and osteoporotic fractures in persons with a spinal cord injury or disorder: A systematic scoping review. ( 29745791 )
2018
36
Left in limbo - Experiences and needs among postmenopausal women newly diagnosed with osteoporosis without preceding osteoporotic fractures: A qualitative study. ( 29392982 )
2018
37
Does Trabecular Bone Score (TBS) improve the predictive ability of FRAX® for major osteoporotic fractures according to the Japanese Population-Based Osteoporosis (JPOS) cohort study? ( 29468478 )
2018
38
Gender differences in anti-osteoporosis drug treatment after osteoporotic fractures. ( 29536198 )
2018
39
Osteoporotic fractures and obesity affect frailty progression: a longitudinal analysis of the Canadian multicentre osteoporosis study. ( 29304836 )
2018
40
Cortical Fractal Analysis and Collagen Crosslinks Content in Femoral Neck After Osteoporotic Fracture in Postmenopausal Women: Comparison with Osteoarthritis. ( 29249023 )
2018
41
Osteoporotic Fracture Risk and Health Care Burden in Patients With Cirrhosis. ( 30096060 )
2018
42
Visualisation of the unmet treatment need of osteoporotic fracture in Taiwan: A nationwide cohort study. ( 30144247 )
2018
43
Impact of bisphosphonate compliance on the risk of osteoporotic fracture in France. ( 30341636 )
2018
44
Nutritional Status and Osteoporotic Fracture Rehabilitation Outcomes in Older Adults. ( 30376425 )
2018
45
Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model. ( 30423942 )
2018
46
The association between 10-year fracture risk by FRAX and osteoporotic fractures with disease activity in patients with rheumatoid arthritis. ( 30039267 )
2018
47
FRAX tool underestimates the risk of osteoporotic fractures in mental disorders. ( 29463572 )
2018
48
Danish, national cross-sectional observational study on the prevalence of prior major osteoporotic fractures in adults presenting with hip fracture-limitations and scope for fracture liaison services in prevention of hip fracture. ( 28965215 )
2018
49
Predictors of change of trabecular bone score (TBS) in older men: results from the Osteoporotic Fractures in Men (MrOS) Study. ( 29090329 )
2018
50
OSTEOPOROTIC FRACTURES DURING BISPHOSPHONATE DRUG HOLIDAY. ( 29144808 )
2018

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

Pathways related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 COL1A1 IL6
2 11.32 COL1A1 IL6
3 11.24 COL1A1 IL6
4 10.65 IL6 MTHFR
5 10.45 COL1A1 IL6 TNFRSF11B
6 10.1 COL1A1 TNFRSF11B

GO Terms for Osteoporotic Fracture

Biological processes related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.48 ESR1 IL6
2 platelet activation GO:0030168 9.46 COL1A1 IL6
3 response to estradiol GO:0032355 9.43 COL1A1 ESR1
4 osteoblast differentiation GO:0001649 9.4 COL1A1 LGR4
5 positive regulation of canonical Wnt signaling pathway GO:0090263 9.37 COL1A1 LGR4
6 response to drug GO:0042493 9.33 COL1A1 MTHFR TNFRSF11B
7 response to nutrient GO:0007584 9.32 COL1A1 TNFRSF11B
8 response to estrogen GO:0043627 9.26 ESR1 TNFRSF11B
9 positive regulation of transcription, DNA-templated GO:0045893 9.26 COL1A1 ESR1 IL6 LGR4
10 negative regulation of bone resorption GO:0045779 8.62 IL6 TNFRSF11B

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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