MCID: OST097
MIFTS: 36

Osteoporotic Fracture

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

MalaCards integrated aliases for Osteoporotic Fracture:

Name: Osteoporotic Fracture 56
Osteoporotic Fractures 74

Classifications:



External Ids:

UMLS 74 C0521170

Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteoporosis and osteonecrosis. An important gene associated with Osteoporotic Fracture is LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include bone, heart and kidney, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 osteoporosis 30.2 COL1A1 ESR1 IL6 TNFRSF11B
2 osteonecrosis 29.6 MTHFR TNFRSF11B
3 bone disease 29.4 COL1A1 IL6 TNFRSF11B
4 chronic kidney failure 29.4 IL6 MTHFR TNFRSF11B
5 periodontal disease 29.2 IL6 TNFRSF11B
6 bone resorption disease 29.2 COL1A1 ESR1 IL6 TNFRSF11B
7 bone mineral density quantitative trait locus 18 11.9
8 bone mineral density quantitative trait locus 8 10.6
9 bone mineral density quantitative trait locus 15 10.6
10 osteoarthritis 10.5
11 breast cancer 10.4
12 rheumatoid arthritis 10.4
13 arthritis 10.4
14 bone mineral density quantitative trait locus 3 10.3
15 liver disease 10.3
16 atrial fibrillation 10.2
17 nonalcoholic fatty liver disease 10.2
18 fatty liver disease 10.2
19 diabetes mellitus 10.2
20 spinal cord injury 10.2
21 pelvic organ prolapse 10.1 COL1A1 ESR1
22 prostate cancer 10.1
23 prostate cancer, hereditary, 8 10.1
24 macular degeneration, age-related, 1 10.1
25 prostate cancer, hereditary, 6 10.1
26 hepatitis 10.1
27 hepatitis c 10.1
28 sudden sensorineural hearing loss 10.0 IL6 MTHFR
29 collagen disease 10.0 COL1A1 IL6
30 endometrial disease 10.0 ESR1 IL6
31 vaginitis 10.0 ESR1 IL6
32 gastroschisis 10.0 IL6 MTHFR
33 nephrolithiasis, calcium oxalate 10.0
34 schizophrenia 10.0
35 insulin-like growth factor i 10.0
36 aging 10.0
37 body mass index quantitative trait locus 1 10.0
38 anorexia nervosa 10.0
39 pulmonary disease, chronic obstructive 10.0
40 hepatitis c virus 10.0
41 hyperprolactinemia 10.0
42 nephrolithiasis 10.0
43 hyperparathyroidism 10.0
44 impotence 10.0
45 kidney disease 10.0
46 rere-related disorders 10.0
47 depression 10.0
48 ischemic heart disease 10.0 IL6 MTHFR
49 encephalomalacia 10.0 IL6 MTHFR
50 central retinal vein occlusion 10.0 IL6 MTHFR

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

MGI Mouse Phenotypes related to Osteoporotic Fracture:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.99 COL1A1 ESR1 IL6 LGR4 MTHFR TNFRSF11B
2 cardiovascular system MP:0005385 9.95 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
3 cellular MP:0005384 9.93 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
4 immune system MP:0005387 9.89 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
5 integument MP:0010771 9.88 COL1A1 ESR1 IL6 LGR4 MTHFR
6 mortality/aging MP:0010768 9.88 COL1A1 ESR1 IL6 LGR4 MTHFR TNFRSF11B
7 adipose tissue MP:0005375 9.86 COL1A1 ESR1 IL6 LGR4
8 digestive/alimentary MP:0005381 9.83 COL1A1 ESR1 IL6 LGR4
9 liver/biliary system MP:0005370 9.83 COL1A1 ESR1 IL6 LGR4 MTHFR
10 nervous system MP:0003631 9.77 COL1A1 ESR1 IL6 LGR4 MTHFR
11 limbs/digits/tail MP:0005371 9.76 COL1A1 ESR1 MTHFR TNFRSF11B
12 no phenotypic analysis MP:0003012 9.62 COL1A1 ESR1 LGR4 MTHFR
13 renal/urinary system MP:0005367 9.56 COL1A1 ESR1 IL6 LGR4
14 reproductive system MP:0005389 9.55 COL1A1 ESR1 IL6 LGR4 MTHFR
15 skeleton MP:0005390 9.35 COL1A1 ESR1 IL6 MTHFR TNFRSF11B
16 vision/eye MP:0005391 8.92 COL1A1 IL6 LGR4 MTHFR

Drugs & Therapeutics for Osteoporotic Fracture

Search Clinical Trials , NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

42
Bone, Heart, Kidney, Prostate, Spinal Cord, Testes, Thyroid

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 1304)
# Title Authors Year
1
Letter: nonalcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. ( 30868628 )
2019
2
Letter: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density-authors' reply. ( 30868629 )
2019
3
Systematic review and meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. ( 30600540 )
2019
4
Association between hepatitis C virus infection and osteoporotic fracture risk among postmenopausal women: a cross-sectional investigation in Taiwan. ( 30782676 )
2019
5
Kidney Stones and Risk of Osteoporotic Fracture in Chronic Kidney Disease. ( 30760766 )
2019
6
Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture. ( 30962808 )
2019
7
A coordination project for improvement of osteoporosis medication use among patients who sustained osteoporotic fracture(s). ( 31008370 )
2019
8
Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study. ( 30620891 )
2019
9
Gender differences in anti-osteoporosis drug treatment after osteoporotic fractures. ( 29536198 )
2019
10
Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture. ( 29464358 )
2019
11
Does Trabecular Bone Score (TBS) improve the predictive ability of FRAX® for major osteoporotic fractures according to the Japanese Population-Based Osteoporosis (JPOS) cohort study? ( 29468478 )
2019
12
A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk. ( 30623214 )
2019
13
Letter to editor: Risk Factors for Cement Loosening after Vertebroplasty for Osteoporotic Fracture with Intravertebral Cleft: A retrospective Analysis. ( 30703861 )
2019
14
Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls. ( 30711642 )
2019
15
MiR-214-3p delays fracture healing in rats with osteoporotic fracture through inhibiting BMP/Smad signaling pathway. ( 30720150 )
2019
16
Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene. ( 30729116 )
2019
17
Insertion/deletion polymorphism in the 3' untranslated region of COL1A2 disrupts its interaction with microRNA-382 and leads to decreased susceptibility to osteoporotic fracture. ( 30825231 )
2019
18
Genetic risk factors identified in populations of European descent do not improve the prediction of osteoporotic fracture and bone mineral density in Chinese populations. ( 30988369 )
2019
19
Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation. ( 31002319 )
2019
20
National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention. ( 31009943 )
2019
21
Sustained-release of sclerostin single-chain antibody fragments using Poly (lactic-co-glycolic acid) microspheres for osteoporotic fracture repair. ( 31012249 )
2019
22
Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture. ( 31086410 )
2019
23
Risk of Osteoporotic Fractures after Thyroid-stimulating Hormone Suppression Therapy in Patients with Thyroid Cancer. ( 30899724 )
2019
24
Prospective risk of osteoporotic fractures in patients with advanced chronic obstructive pulmonary disease. ( 29661041 )
2019
25
The risk of subsequent osteoporotic fractures is decreased in subjects experiencing fracture while on denosumab: results from the FREEDOM and FREEDOM Extension studies. ( 30244369 )
2019
26
The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study. ( 30376054 )
2019
27
Adding Lateral Spine Imaging for Vertebral Fractures to Densitometric Screening: Improving Ascertainment of Patients at High Risk of Incident Osteoporotic Fractures. ( 30395687 )
2019
28
Socioeconomic status and risk of osteoporotic fractures and the use of DXA scans: data from the Danish population-based ROSE study. ( 30465216 )
2019
29
Caregiving Intensity and Mortality in Older Women, Accounting for Time-Varying and Lagged Caregiver Status: The Caregiver-Study of Osteoporotic Fractures Study. ( 30649308 )
2019
30
Nordic Innovative Trials to Evaluate osteoPorotic Fractures (NITEP) Collaboration: The Nordic DeltaCon Trial protocol-non-operative treatment versus reversed total shoulder arthroplasty in patients 65 years of age and older with a displaced proximal humerus fracture: a prospective, randomised controlled trial. ( 30700485 )
2019
31
Corrigendum to: The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study. ( 30753451 )
2019
32
High Postural Sway Is an Independent Risk Factor for Osteoporotic Fractures but Not for Mortality in Elderly Women. ( 30811685 )
2019
33
Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women. ( 30837644 )
2019
34
Locked Plating and Advanced Augmentation Techniques in Osteoporotic Fractures. ( 30850075 )
2019
35
Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study. ( 30887076 )
2019
36
Healthcare Resource Utilization and Direct Medical Costs for Patients With Osteoporotic Fractures in China. ( 30909083 )
2019
37
PROFILE OF PATIENTS WITH OSTEOPOROTIC FRACTURES AND FACTORS THAT DECREASE PREVENTION. ( 30988654 )
2019
38
Correction to: Acetylcholinesterase inhibitors and the risk of osteoporotic fractures: nested case-control study. ( 30989401 )
2019
39
A Region-Based Deep Level Set Formulation for Vertebral Bone Segmentation of Osteoporotic Fractures. ( 31011954 )
2019
40
The Effect of Intraoperative Vertebral Anesthesia on Osteoporotic Fractures Treated With Percutaneous Kyphoplasty: A Prospective Cohort Study. ( 31021875 )
2019
41
Investigation of Comorbidity, Trauma History, and Osteoporotic Fractures in the Postmenopausal Population: A Nationwide, Observational, and Cross-Sectional Study of Korean Orthopedic Outpatient Clinics. ( 31079428 )
2019
42
Health State Utility Values of Osteoporotic Fractures among Korean women. ( 31092075 )
2019
43
Association of Nonalcoholic Fatty Liver Disease With Osteoporotic Fractures: A Cross-Sectional Retrospective Study of Chinese Individuals. ( 30083134 )
2018
44
Association of gout with osteoporotic fractures. ( 29955945 )
2018
45
Hepatitis C virus infection and risk of osteoporotic fracture: A systematic review and meta-analysis. ( 29322660 )
2018
46
Chronic kidney disease, cardiovascular disease, and osteoporotic fractures in patients with and without HIV in the US Veteran's Affairs Administration System. ( 30378450 )
2018
47
Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease. ( 28530467 )
2018
48
Effects of Milk and Dairy Products on the Prevention of Osteoporosis and Osteoporotic Fractures in Europeans and Non-Hispanic Whites from North America: A Systematic Review and Updated Meta-Analysis. ( 31089740 )
2018
49
A coordination project for improvement of osteoporosis medication use among patients who sustained an osteoporotic fracture: The Israeli experience. ( 30775556 )
2018
50
Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease. ( 30574465 )
2018

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

Pathways related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 COL1A1 IL6
2 11.32 COL1A1 IL6
3 11.24 COL1A1 IL6
4 10.65 IL6 MTHFR
5 10.45 COL1A1 IL6 TNFRSF11B
6 10.1 COL1A1 TNFRSF11B

GO Terms for Osteoporotic Fracture

Biological processes related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.48 ESR1 IL6
2 platelet activation GO:0030168 9.46 COL1A1 IL6
3 response to estradiol GO:0032355 9.43 COL1A1 ESR1
4 osteoblast differentiation GO:0001649 9.4 COL1A1 LGR4
5 positive regulation of canonical Wnt signaling pathway GO:0090263 9.37 COL1A1 LGR4
6 response to drug GO:0042493 9.33 COL1A1 MTHFR TNFRSF11B
7 response to nutrient GO:0007584 9.32 COL1A1 TNFRSF11B
8 response to estrogen GO:0043627 9.26 ESR1 TNFRSF11B
9 positive regulation of transcription, DNA-templated GO:0045893 9.26 COL1A1 ESR1 IL6 LGR4
10 negative regulation of bone resorption GO:0045779 8.62 IL6 TNFRSF11B

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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