MCID: OST097
MIFTS: 41

Osteoporotic Fracture

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

MalaCards integrated aliases for Osteoporotic Fracture:

Name: Osteoporotic Fracture 55
Osteoporotic Fractures 73

Classifications:



External Ids:

UMLS 73 C0521170

Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteonecrosis and cerebrovascular disease. An important gene associated with Osteoporotic Fracture is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and AGE-RAGE signaling pathway in diabetic complications. The drugs Teriparatide and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and bone marrow, and related phenotypes are growth/size/body region and integument

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 29.3 MTHFR TNFRSF11B
2 cerebrovascular disease 29.2 IL6 MTHFR
3 periodontitis 28.9 IL6 TNFRSF11B
4 periodontal disease 28.7 IL6 TNFRSF11B
5 osteoporosis 28.7 COL1A1 ESR1 IL6 TNFRSF11B
6 bone mineral density quantitative trait locus 18 11.7
7 aging 10.3
8 pelvic organ prolapse 10.2 COL1A1 ESR1
9 osteoarthritis 10.1
10 sudden sensorineural hearing loss 10.1 IL6 MTHFR
11 gastroschisis 10.1 IL6 MTHFR
12 endometrial disease 10.1 ESR1 IL6
13 vaginitis 10.1 ESR1 IL6
14 encephalomalacia 10.1 IL6 MTHFR
15 central retinal vein occlusion 10.1 IL6 MTHFR
16 rheumatoid arthritis 10.1
17 arthritis 10.1
18 hematopoietic stem cell transplantation 10.1 IL6 MTHFR
19 endometritis 10.1 ESR1 IL6
20 retinal vein occlusion 10.0 IL6 MTHFR
21 placenta disease 10.0 IL6 MTHFR
22 female reproductive system disease 10.0 ESR1 IL6
23 breast cancer 10.0
24 reproductive system disease 10.0 ESR1 IL6
25 cerebral palsy 10.0 IL6 MTHFR
26 arteries, anomalies of 9.9 IL6 MTHFR
27 conjunctivitis 9.9
28 atrial fibrillation 9.9
29 type i 9.9
30 hyperprolactinemia 9.9
31 diabetes mellitus 9.9
32 postural hypotension 9.9
33 cervicitis 9.9
34 endometriosis 9.9 ESR1 IL6
35 osteogenesis imperfecta, type i 9.8 COL1A1 TNFRSF11B
36 hyperostosis 9.8 COL1A1 TNFRSF11B
37 hellp syndrome 9.8 IL6 MTHFR
38 diabetic angiopathy 9.8 MTHFR TNFRSF11B
39 atherosclerosis susceptibility 9.8 ESR1 IL6
40 bone remodeling disease 9.8 ESR1 TNFRSF11B
41 carotid stenosis 9.8 MTHFR TNFRSF11B
42 insulin-like growth factor i 9.8
43 empty sella syndrome 9.8
44 spinal cord injury 9.8
45 dystonia 9.8
46 muscular dystrophy, duchenne type 9.8
47 spinal stenosis 9.8
48 cervical dystonia 9.8
49 body mass index quantitative trait locus 1 9.8
50 anorexia nervosa 9.8

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

MGI Mouse Phenotypes related to Osteoporotic Fracture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.77 COL1A1 ESR1 IL6 MTHFR TNFRSF11B
2 integument MP:0010771 9.62 COL1A1 ESR1 IL6 MTHFR
3 limbs/digits/tail MP:0005371 9.56 COL1A1 ESR1 MTHFR TNFRSF11B
4 mortality/aging MP:0010768 9.55 ESR1 IL6 MTHFR TNFRSF11B COL1A1
5 reproductive system MP:0005389 9.26 COL1A1 ESR1 IL6 MTHFR
6 skeleton MP:0005390 9.02 COL1A1 ESR1 IL6 MTHFR TNFRSF11B

Drugs & Therapeutics for Osteoporotic Fracture

Drugs for Osteoporotic Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 52232-67-4 16133850
2
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
3
Denosumab Approved Phase 4,Phase 3,Not Applicable 615258-40-7
4
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
5
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
6
Etidronic acid Approved Phase 4,Phase 3 7414-83-7, 2809-21-4 3305
7
Zoledronic acid Approved Phase 4,Phase 3 118072-93-8 68740
8
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
9
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
10 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
11 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
12 Ergocalciferols Phase 4,Phase 3,Phase 2
13 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable
14 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
16 Risedronate Sodium Phase 4,Phase 3 115436-72-1
17 calcium channel blockers Phase 4,Phase 3
18 Central Nervous System Depressants Phase 4
19 Sodium Channel Blockers Phase 4
20 Anesthetics Phase 4,Phase 3,Phase 2
21 Anesthetics, Local Phase 4
22 Diphosphonates Phase 4,Phase 3,Phase 2,Not Applicable
23 Diuretics, Potassium Sparing Phase 4
24 Anti-Arrhythmia Agents Phase 4
25 Peripheral Nervous System Agents Phase 4,Phase 2
26 Hypoglycemic Agents Phase 4
27 Liver Extracts Phase 4
28 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2
29 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2
30
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
31
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
32
Alendronate Approved Phase 3 121268-17-5, 66376-36-1 2088
33
Tamoxifen Approved Phase 3 10540-29-1 2733526
34
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
35
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
36
Buserelin Approved, Investigational Phase 3 57982-77-1
37
Flutamide Approved, Investigational Phase 3 13311-84-7 3397
38
Goserelin Approved Phase 3 65807-02-5 47725 5311128
39
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
40
Bicalutamide Approved Phase 3 90357-06-5 56069 2375
41
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 6221 5280795
42
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
43 Deslorelin Investigational, Vet_approved Phase 3 57773-65-6
44 glucocorticoids Phase 3,Phase 2,Not Applicable
45 Androgens Phase 3
46 Hormone Antagonists Phase 3,Phase 2,Not Applicable
47 Hormones Phase 3,Phase 2,Not Applicable
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
49 Ibandronic acid Phase 3
50 Selective Estrogen Receptor Modulators Phase 3

Interventional clinical trials:

(show top 50) (show all 142)
# Name Status NCT ID Phase Drugs
1 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
2 Vertebroplasty Compared With a Sham-procedure for Painful Acute Osteoporotic Vertebral Fractures Completed NCT01537770 Phase 4
3 Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting Completed NCT01847898 Phase 4
4 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
5 Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) Recruiting NCT02589600 Phase 4 Zoledronic acid
6 Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty Recruiting NCT02148848 Phase 4 Risedronate
7 Preventing Osteoporosis Using Denosumab Recruiting NCT02753283 Phase 4 denosumab;Placebo
8 Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer Unknown status NCT00957606 Phase 3
9 Early Rehabilitation After Hip Fracture Unknown status NCT00133640 Phase 3 cholecalciferol
10 Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women Unknown status NCT00697463 Phase 2, Phase 3 Teriparatide (PTH 1-34)
11 Secondary Prevention of Osteoporotic Fractures in Residents of Long-Term Care Facilities Completed NCT00280943 Phase 2, Phase 3
12 BONDIR Study: A Study of Intravenous Bonviva (Ibandronate) After Recent Vertebral Osteoporotic Fracture in Patients With Osteoporosis. Completed NCT00493623 Phase 3 Placebo;ibandronate [Bonviva/Boniva]
13 Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture Completed NCT00046254 Phase 3 Zoledronic Acid
14 Vertebroplasty for the Treatment of Fractures Due to Osteoporosis Completed NCT00068822 Phase 3
15 Secondary Prevention of Osteoporosis Completed NCT00421343 Phase 3 alendronate with cholecalciferol;calcium carbonate with cholecalciferol
16 Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer Completed NCT00859703 Phase 3 Risedronate;Placebo
17 Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing Completed NCT01293721 Phase 2, Phase 3
18 Low-magnitude High-frequency Vibration Study on Fracture Rate in Community Elderly Completed NCT00973167 Phase 2, Phase 3
19 The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis Completed NCT00252421 Phase 3 Nitroglycerin ointment 15 mg/day daily for 24 month;Placebo ointment daily for 24 month
20 BREAST CANCER AND EXERCISE Completed NCT00639210 Phase 3
21 Calcium and Vitamin D Malnutrition in Elderly Women Completed NCT00352170 Phase 3
22 Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy Completed NCT00053898 Phase 3 anastrozole;tamoxifen citrate
23 Bone Mineral Density in Postmenopausal Women With Primary Breast Cancer Who Are Receiving Treatment on Clinical Trial CAN-NCIC-MA27 Completed NCT00354302 Phase 3 alendronate sodium;calcium gluconate;risedronate sodium
24 Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis Completed NCT00670319 Phase 3 Raloxifene HCL;Raloxifene HCL;Placebo
25 Comparison of the Effects of 2 Drugs on Lumbar Spine Volumetric BMD in Men With Glucocorticoid-Induced Osteoporosis Completed NCT00503399 Phase 3 Teriparatide;Risedronate
26 Oligopin Supplementation and Bone Turnover Markers and Antioxidant Changes in Postmenopausal Osteopenic Women Recruiting NCT03260803 Phase 3 Oligopin;Placebo
27 Effect of Teriparatide on Fracture Healing in Patients With Incomplete Atypical Femur Fractures Recruiting NCT01896011 Phase 3
28 Different Durations of Adjuvant Anastrozole Therapy After 2 to 3 Years Tamoxifen Therapy in Breast Cancer Active, not recruiting NCT00301457 Phase 3 Anastrozole
29 Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer Active, not recruiting NCT01546987 Phase 3 bicalutamide;buserelin;flutamide;goserelin acetate;leuprolide acetate;orteronel;triptorelin
30 Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet. Enrolling by invitation NCT03027557 Phase 3 Cinacalcet 30 mg Tablet;Denosumab Inj 60 mg/ml
31 Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy Terminated NCT01512446 Phase 3 Alendronate;Placebo
32 Effects of Whole Body Vibration on Postmenopausal Risk-factors in Elderly Women Terminated NCT00667667 Phase 3
33 Evaluation of the Proximal Femoral Nail Antirotation With Cement Augmentation in Osteoporotic Femoral Neck Fractures Unknown status NCT01235169 Phase 1, Phase 2
34 Phase 2a Study on Intravenous Infusion of Autologous Osteoblastic Cells in Severe Osteoporosis Unknown status NCT02061995 Phase 2 PREOB® Intravenous Infusion
35 Effectiveness of Physiotherapy for Osteoporotic Spinal Fracture Completed NCT00638768 Phase 2
36 Can Parathyroid Hormone Injections Reverse Glucocorticoid-induced Osteoporosis Completed NCT00004993 Phase 2 Parathyroid hormone (hPTH 1-34)
37 Shock Wave Therapy for Osteoporosis Completed NCT02630381 Phase 2
38 Study Evaluating Changes In Bone Mineral Density (BMD), And Safety Of Rhbmp-2/CPM In Subjects With Decreased BMD Completed NCT00752557 Phase 2 rhBMP-2/CPM injection and bisphosphonates, calcium, and vitamin D (oral bisphosphonate therapy);rhBMP-2/CPM injection and bisphosphonates, calcium, and vitamin D (oral bisphosphonate therapy);bisphosphonates, calcium, and vitamin D
39 Tocilizumab for Patients With Giant Cell Arteritis Completed NCT01450137 Phase 2 Tocilizumab + Glucocorticoids (GCs);Placebo + Glucocorticoids (GCs)
40 Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome Completed NCT01051778 Phase 2 enoxaparin 40mg plus low dose aspirin;Heparin calcium5,000 U twice daily plus low dose aspirin
41 PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial Recruiting NCT02972424 Phase 2 Teriparatide Prefilled Syringe;Placebo
42 Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts Terminated NCT01532076 Phase 2
43 Gene-Polymorphies in the P2X7 Gene in Patients With Osteoporotic Fractures Unknown status NCT00293189
44 Secondary Fracture Prevention in Patients Who Suffered From Osteoporotic Fracture Unknown status NCT02223572 Not Applicable
45 Osteoporosis and Knee Insufficiency Fracture Unknown status NCT02332681
46 Study of A Special Vessel Subtype in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture Unknown status NCT02750046 Not Applicable
47 RCT: Added Value of Coordinator for the Management of Hip Fracture Patients Unknown status NCT01785381 Not Applicable
48 Prevalence and Predictors of Osteoporosis in the Beijing's Urban Population Unknown status NCT01476150
49 Osteoprosis in Type 2 Diabetic Patients- a Cohort Study Unknown status NCT01846533
50 Osteoporosis Coordinator for Low Volume Community Hospitals Unknown status NCT00511693 Not Applicable

Search NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

41
Bone, Prostate, Bone Marrow, Liver, Heart, Neutrophil, Testes

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 452)
# Title Authors Year
1
Identifying Unmet Treatment Needs for Patients With Osteoporotic Fracture: Feasibility Study for an Electronic Clinical Surveillance System. ( 29691201 )
2018
2
MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression. ( 29786747 )
2018
3
Discrete particle model for cement infiltration within open-cell structures: Prevention of osteoporotic fracture. ( 29898001 )
2018
4
Hepatitis C virus infection and risk of osteoporotic fracture: A systematic review and meta-analysis. ( 29322660 )
2018
5
Validated computational framework for efficient systematic evaluation of osteoporotic fracture fixation in the proximal humerus. ( 29728330 )
2018
6
Therapist's practice patterns for subsequent fall/osteoporotic fracture prevention for patients with a distal radius fracture. ( 29705078 )
2018
7
Comments on Li et al.: Meta-analysis of hypertension and osteoporotic fracture risk in women and men. ( 28986611 )
2018
8
Prevalence and Associated Risk Factors of Sarcopenia in Female Patients with Osteoporotic Fracture. ( 29564307 )
2018
9
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29651509 )
2018
10
Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT. ( 29314261 )
2018
11
Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture. ( 29464358 )
2018
12
Higher dietary glycemic index and glycemic load values increase the risk of osteoporotic fracture in the PREvenciA^n con DIeta MEDiterrA!nea (PREDIMED)-Reus trial. ( 29746627 )
2018
13
Impact of a fracture liaison service on patient management after an osteoporotic fracture: the CHUV FLS. ( 29376552 )
2018
14
The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. ( 29304151 )
2018
15
Dual modulation of bone formation and resorption with zoledronic acid-loaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study. ( 29079514 )
2018
16
The analysis of MSTMOVCF (Multi-segment thoracolumbar mild osteoporotic fractures surgery or conservative treatment) based on ASTLOF (the assessment system of thoracolumbar osteoporotic fracture). ( 29844542 )
2018
17
Usefulness of the Trabecular Bone Score for assessing the risk of osteoporotic fracture. ( 29329765 )
2018
18
Association of gout with osteoporotic fractures. ( 29955945 )
2018
19
Development of a risk assessment tool for osteoporotic fracture prevention: A claims data approach. ( 29421456 )
2018
20
Anxa2 attenuates osteoblast growth and is associated with hip BMD and osteoporotic fracture in Chinese elderly. ( 29570731 )
2018
21
Treatment costs and cost drivers among osteoporotic fracture patients in Japan: a retrospective database analysis. ( 29696390 )
2018
22
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29067485 )
2018
23
Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing. ( 29216500 )
2018
24
The use of a femoral distractor in the presence of an intramedullary nail proximal to an osteoporotic fracture. ( 29543057 )
2018
25
Meta-analysis of hypertension and osteoporotic fracture risk in women and men: response to comments by RodrA-guez et al. ( 28986610 )
2018
26
Association of Bone Morphogenetic Protein (BMP)/Smad Signaling Pathway with Fracture Healing and Osteogenic Ability in Senile Osteoporotic Fracture in Humans and Rats. ( 29938690 )
2018
27
Characteristics of bone biochemical indices in predicting secondary osteoporotic fracture after intertrochanteric fracture in elderly women. ( 29662773 )
2018
28
Surgery for Multisegment Thoracolumbar Mild Osteoporotic Fractures: Revised Assessment System of Thoracolumbar Osteoporotic Fracture. ( 29588238 )
2018
29
Incidence and risk factors of medical complications and direct medical costs after osteoporotic fracture among patients in China. ( 29488018 )
2018
30
The Role of Exercises in Osteoporotic Fracture Prevention and Current Care Gaps. Where Are We Now? Recent Updates. ( 28786812 )
2017
31
Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease. ( 28530467 )
2017
32
Validity of major osteoporotic fracture diagnosis codes in the Clinical Data Analysis and Reporting System in Hong Kong. ( 28371079 )
2017
33
Community osteoporosis screening services for the prevention of osteoporotic fractures in population health: a literature review. ( 28448327 )
2017
34
The application of the FRIDEX calibration of the FRAX tool to determine the absolute risk of osteoporotic fracture among Spanish women. ( 29221875 )
2017
35
Healthcare Costs of Osteoporotic Fracture in Korea: Information from the National Health Insurance Claims Database, 2008-2011. ( 28642857 )
2017
36
Assessment of osteoporotic fracture risk in urban Indian population using quantitative ultrasonography & FRAX tool. ( 29578195 )
2017
37
Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. ( 28587685 )
2017
38
Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. ( 28451733 )
2017
39
Risk of Osteoporotic Fracture After Steroid Injections in Patients With Medicare. ( 29099886 )
2017
40
High incidence of vertebral osteoporotic fracture within the first year after liver transplantation. ( 28516878 )
2017
41
The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exercise to reduce risk of osteoporotic fracture in older men with low bone mass. ( 28611110 )
2017
42
Evaluating osteoporotic fracture risk with the Fracture Risk Assessment Tool in Chinese patients with rheumatoid arthritis. ( 28471962 )
2017
43
The Efficacy of Bisphosphonates for Prevention of Osteoporotic Fracture: An Update Meta-analysis. ( 28326300 )
2017
44
Relationship between vitamin D, osteoporotic fracture and falls. ( 28625513 )
2017
45
A Model for Assessing the Clinical and Economic Benefits of Bone-forming Agents for Reducing Fractures in Postmenopausal Women at High, Near-term Risk of Osteoporotic Fracture. ( 28629610 )
2017
46
Increased detection of genetic loci associated with risk predictors of osteoporotic fracture using a pleiotropic cFDR method. ( 28373146 )
2017
47
Association between renin-angiotensin-aldosterone system blockade and future osteoporotic fracture risk in hypertensive population: A population-based cohort study in Taiwan. ( 29145244 )
2017
48
Prevalence and incidence of osteoporotic fractures in patients on long-term glucocorticoid treatment for rheumatic diseases: the Glucocorticoid Induced OsTeoporosis TOol (GIOTTO) study. ( 28535619 )
2017
49
Organic Gallium Treatment Improves Osteoporotic Fracture Healing Through Affecting the OPG/RANKL Ratio and Expression of Serum Inflammatory Cytokines in Ovariectomized Rats. ( 28836172 )
2017
50
Getting Osteoporotic Fracture Risk Into Vascular Structure and Functiona88- Do You Know Your FRAX(Ar) Score? ( 28331114 )
2017

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

Pathways related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 COL1A1 IL6
2 11.32 COL1A1 IL6
3 11.24 COL1A1 IL6
4 10.65 IL6 MTHFR
5 10.45 COL1A1 IL6 TNFRSF11B
6 10.1 COL1A1 TNFRSF11B

GO Terms for Osteoporotic Fracture

Biological processes related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 COL1A1 ESR1 IL6
2 skeletal system development GO:0001501 9.46 COL1A1 TNFRSF11B
3 platelet activation GO:0030168 9.43 COL1A1 IL6
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.4 ESR1 IL6
5 response to estradiol GO:0032355 9.37 COL1A1 ESR1
6 response to nutrient GO:0007584 9.26 COL1A1 TNFRSF11B
7 response to estrogen GO:0043627 9.16 ESR1 TNFRSF11B
8 response to drug GO:0042493 9.13 COL1A1 MTHFR TNFRSF11B
9 negative regulation of bone resorption GO:0045779 8.62 IL6 TNFRSF11B

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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