MCID: OST097
MIFTS: 36

Osteoporotic Fracture

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

MalaCards integrated aliases for Osteoporotic Fracture:

Name: Osteoporotic Fracture 56
Osteoporotic Fractures 74

Classifications:



External Ids:

UMLS 74 C0521170

Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteoporosis and osteonecrosis. An important gene associated with Osteoporotic Fracture is LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include bone, breast and liver, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 osteoporosis 30.2 COL1A1 ESR1 IL6 TNFRSF11B
2 osteonecrosis 29.6 MTHFR TNFRSF11B
3 chronic kidney failure 29.4 IL6 MTHFR TNFRSF11B
4 periodontal disease 29.2 IL6 TNFRSF11B
5 bone resorption disease 29.2 COL1A1 ESR1 IL6 TNFRSF11B
6 bone disease 29.2 COL1A1 IL6 TNFRSF11B
7 bone mineral density quantitative trait locus 18 11.9
8 osteoarthritis 10.5
9 bone mineral density quantitative trait locus 8 10.4
10 bone mineral density quantitative trait locus 15 10.4
11 breast cancer 10.4
12 rheumatoid arthritis 10.3
13 arthritis 10.3
14 bone mineral density quantitative trait locus 3 10.3
15 liver disease 10.3
16 nonalcoholic fatty liver disease 10.2
17 fatty liver disease 10.2
18 diabetes mellitus 10.2
19 spinal cord injury 10.2
20 atrial fibrillation 10.2
21 pelvic organ prolapse 10.1 COL1A1 ESR1
22 prostate cancer 10.1
23 prostate cancer, hereditary, 8 10.1
24 macular degeneration, age-related, 1 10.1
25 prostate cancer, hereditary, 6 10.1
26 hepatitis 10.1
27 hepatitis c 10.1
28 sudden sensorineural hearing loss 10.0 IL6 MTHFR
29 collagen disease 10.0 COL1A1 IL6
30 endometrial disease 10.0 ESR1 IL6
31 vaginitis 10.0 ESR1 IL6
32 gastroschisis 10.0 IL6 MTHFR
33 ischemic heart disease 10.0 IL6 MTHFR
34 encephalomalacia 10.0 IL6 MTHFR
35 central retinal vein occlusion 10.0 IL6 MTHFR
36 nephrolithiasis, calcium oxalate 10.0
37 schizophrenia 10.0
38 aging 10.0
39 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 10.0
40 body mass index quantitative trait locus 1 10.0
41 anorexia nervosa 10.0
42 pulmonary disease, chronic obstructive 10.0
43 hepatitis c virus 10.0
44 hyperprolactinemia 10.0
45 nephrolithiasis 10.0
46 hyperparathyroidism 10.0
47 disease of mental health 10.0
48 impotence 10.0
49 kidney disease 10.0
50 rere-related disorders 10.0

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

MGI Mouse Phenotypes related to Osteoporotic Fracture:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.99 COL1A1 ESR1 IL6 LGR4 MTHFR TNFRSF11B
2 cardiovascular system MP:0005385 9.95 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
3 cellular MP:0005384 9.93 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
4 immune system MP:0005387 9.89 COL1A1 ESR1 IL6 LGR4 TNFRSF11B
5 integument MP:0010771 9.88 COL1A1 ESR1 IL6 LGR4 MTHFR
6 mortality/aging MP:0010768 9.88 COL1A1 ESR1 IL6 LGR4 MTHFR TNFRSF11B
7 adipose tissue MP:0005375 9.86 COL1A1 ESR1 IL6 LGR4
8 digestive/alimentary MP:0005381 9.83 COL1A1 ESR1 IL6 LGR4
9 liver/biliary system MP:0005370 9.83 COL1A1 ESR1 IL6 LGR4 MTHFR
10 nervous system MP:0003631 9.77 COL1A1 ESR1 IL6 LGR4 MTHFR
11 limbs/digits/tail MP:0005371 9.76 COL1A1 ESR1 MTHFR TNFRSF11B
12 no phenotypic analysis MP:0003012 9.62 COL1A1 ESR1 LGR4 MTHFR
13 renal/urinary system MP:0005367 9.56 COL1A1 ESR1 IL6 LGR4
14 reproductive system MP:0005389 9.55 COL1A1 ESR1 IL6 LGR4 MTHFR
15 skeleton MP:0005390 9.35 COL1A1 ESR1 IL6 MTHFR TNFRSF11B
16 vision/eye MP:0005391 8.92 COL1A1 IL6 LGR4 MTHFR

Drugs & Therapeutics for Osteoporotic Fracture

Search Clinical Trials , NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

42
Bone, Breast, Liver, Testes, Heart, Kidney, Spinal Cord

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 1266)
# Title Authors Year
1
Letter: nonalcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. ( 30868628 )
2019
2
Letter: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density-authors' reply. ( 30868629 )
2019
3
Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. ( 30600540 )
2019
4
Association between hepatitis C virus infection and osteoporotic fracture risk among postmenopausal women: a cross-sectional investigation in Taiwan. ( 30782676 )
2019
5
Kidney Stones and Risk of Osteoporotic Fracture in Chronic Kidney Disease. ( 30760766 )
2019
6
Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study. ( 30620891 )
2019
7
Does Trabecular Bone Score (TBS) improve the predictive ability of FRAX® for major osteoporotic fractures according to the Japanese Population-Based Osteoporosis (JPOS) cohort study? ( 29468478 )
2019
8
Gender differences in anti-osteoporosis drug treatment after osteoporotic fractures. ( 29536198 )
2019
9
Risk of Osteoporotic Fractures after Thyroid-stimulating Hormone Suppression Therapy in Patients with Thyroid Cancer. ( 30899724 )
2019
10
Prospective risk of osteoporotic fractures in patients with advanced chronic obstructive pulmonary disease. ( 29661041 )
2019
11
Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women. ( 30837644 )
2019
12
Locked Plating and Advanced Augmentation Techniques in Osteoporotic Fractures. ( 30850075 )
2019
13
Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study. ( 30887076 )
2019
14
Healthcare Resource Utilization and Direct Medical Costs for Patients With Osteoporotic Fractures in China. ( 30909083 )
2019
15
The risk of subsequent osteoporotic fractures is decreased in subjects experiencing fracture while on denosumab: results from the FREEDOM and FREEDOM Extension studies. ( 30244369 )
2019
16
Caregiving Intensity and Mortality in Older Women, Accounting for Time-Varying and Lagged Caregiver Status: The Caregiver-Study of Osteoporotic Fractures Study. ( 30649308 )
2019
17
Nordic Innovative Trials to Evaluate osteoPorotic Fractures (NITEP) Collaboration: The Nordic DeltaCon Trial protocol-non-operative treatment versus reversed total shoulder arthroplasty in patients 65 years of age and older with a displaced proximal humerus fracture: a prospective, randomised controlled trial. ( 30700485 )
2019
18
Corrigendum to: The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study. ( 30753451 )
2019
19
High Postural Sway Is an Independent Risk Factor for Osteoporotic Fractures but Not for Mortality in Elderly Women. ( 30811685 )
2019
20
Identifying Unmet Treatment Needs for Patients With Osteoporotic Fracture: Feasibility Study for an Electronic Clinical Surveillance System. ( 29691201 )
2018
21
MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression. ( 29786747 )
2018
22
Discrete particle model for cement infiltration within open-cell structures: Prevention of osteoporotic fracture. ( 29898001 )
2018
23
Hepatitis C virus infection and risk of osteoporotic fracture: A systematic review and meta-analysis. ( 29322660 )
2018
24
Validated computational framework for efficient systematic evaluation of osteoporotic fracture fixation in the proximal humerus. ( 29728330 )
2018
25
Therapist's practice patterns for subsequent fall/osteoporotic fracture prevention for patients with a distal radius fracture. ( 29705078 )
2018
26
Comments on Li et al.: Meta-analysis of hypertension and osteoporotic fracture risk in women and men. ( 28986611 )
2018
27
Prevalence and Associated Risk Factors of Sarcopenia in Female Patients with Osteoporotic Fracture. ( 29564307 )
2018
28
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29651509 )
2018
29
Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT. ( 29314261 )
2018
30
Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture. ( 29464358 )
2018
31
Higher dietary glycemic index and glycemic load values increase the risk of osteoporotic fracture in the PREvenciA^n con DIeta MEDiterrA!nea (PREDIMED)-Reus trial. ( 29746627 )
2018
32
Impact of a fracture liaison service on patient management after an osteoporotic fracture: the CHUV FLS. ( 29376552 )
2018
33
The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. ( 29304151 )
2018
34
Dual modulation of bone formation and resorption with zoledronic acid-loaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study. ( 29079514 )
2018
35
The analysis of MSTMOVCF (Multi-segment thoracolumbar mild osteoporotic fractures surgery or conservative treatment) based on ASTLOF (the assessment system of thoracolumbar osteoporotic fracture). ( 29844542 )
2018
36
Usefulness of the Trabecular Bone Score for assessing the risk of osteoporotic fracture. ( 29329765 )
2018
37
Association of gout with osteoporotic fractures. ( 29955945 )
2018
38
Development of a risk assessment tool for osteoporotic fracture prevention: A claims data approach. ( 29421456 )
2018
39
Anxa2 attenuates osteoblast growth and is associated with hip BMD and osteoporotic fracture in Chinese elderly. ( 29570731 )
2018
40
Treatment costs and cost drivers among osteoporotic fracture patients in Japan: a retrospective database analysis. ( 29696390 )
2018
41
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29067485 )
2018
42
Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing. ( 29216500 )
2018
43
The use of a femoral distractor in the presence of an intramedullary nail proximal to an osteoporotic fracture. ( 29543057 )
2018
44
Meta-analysis of hypertension and osteoporotic fracture risk in women and men: response to comments by RodrA-guez et al. ( 28986610 )
2018
45
Association of Bone Morphogenetic Protein (BMP)/Smad Signaling Pathway with Fracture Healing and Osteogenic Ability in Senile Osteoporotic Fracture in Humans and Rats. ( 29938690 )
2018
46
Characteristics of bone biochemical indices in predicting secondary osteoporotic fracture after intertrochanteric fracture in elderly women. ( 29662773 )
2018
47
Surgery for Multisegment Thoracolumbar Mild Osteoporotic Fractures: Revised Assessment System of Thoracolumbar Osteoporotic Fracture. ( 29588238 )
2018
48
Incidence and risk factors of medical complications and direct medical costs after osteoporotic fracture among patients in China. ( 29488018 )
2018
49
The association between 10-year fracture risk by FRAX and osteoporotic fractures with disease activity in patients with rheumatoid arthritis. ( 30039267 )
2018
50
Association of Nonalcoholic Fatty Liver Disease With Osteoporotic Fractures: A Cross-Sectional Retrospective Study of Chinese Individuals. ( 30083134 )
2018

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

Pathways related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 COL1A1 IL6
2 11.32 COL1A1 IL6
3 11.24 COL1A1 IL6
4 10.65 IL6 MTHFR
5 10.45 COL1A1 IL6 TNFRSF11B
6 10.1 COL1A1 TNFRSF11B

GO Terms for Osteoporotic Fracture

Biological processes related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.48 ESR1 IL6
2 platelet activation GO:0030168 9.46 COL1A1 IL6
3 response to estradiol GO:0032355 9.43 COL1A1 ESR1
4 osteoblast differentiation GO:0001649 9.4 COL1A1 LGR4
5 positive regulation of canonical Wnt signaling pathway GO:0090263 9.37 COL1A1 LGR4
6 response to drug GO:0042493 9.33 COL1A1 MTHFR TNFRSF11B
7 response to nutrient GO:0007584 9.32 COL1A1 TNFRSF11B
8 response to estrogen GO:0043627 9.26 ESR1 TNFRSF11B
9 positive regulation of transcription, DNA-templated GO:0045893 9.26 COL1A1 ESR1 IL6 LGR4
10 negative regulation of bone resorption GO:0045779 8.62 IL6 TNFRSF11B

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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