MCID: OST008
MIFTS: 38

Osteosclerotic Myeloma

Categories: Blood diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Osteosclerotic Myeloma

MalaCards integrated aliases for Osteosclerotic Myeloma:

Name: Osteosclerotic Myeloma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9541
SNOMED-CT 68 42215000
UMLS 73 C1510415

Summaries for Osteosclerotic Myeloma

MalaCards based summary : Osteosclerotic Myeloma is related to poems syndrome and peripheral nervous system disease. An important gene associated with Osteosclerotic Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Influenza A and NF-KappaB Family Pathway. Affiliated tissues include bone, b cells and lung, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Osteosclerotic Myeloma

Diseases related to Osteosclerotic Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 poems syndrome 33.4 IL1B IL6 MYOM2 TNF
2 peripheral nervous system disease 30.5 IL6 MAG MYOM2 TNF
3 chronic polyneuropathy 30.3 MAG MYOM2
4 polyneuropathy 10.5
5 neuropathy 10.4
6 plasma protein metabolism disease 10.3 MAG MYOM2
7 streptococcal meningitis 10.3 MYOM2 TNF
8 cysticercosis 10.3 IL1B IL6
9 vaginal disease 10.3 IL1B IL6
10 vaginitis 10.3 IL1B IL6
11 autoimmune gastritis 10.3 IL6 TNF
12 meconium aspiration syndrome 10.3 IL6 TNF
13 listeriosis 10.2 IL6 TNF
14 louse-borne relapsing fever 10.2 IL6 TNF
15 mononeuritis multiplex 10.2 MAG MYOM2
16 burning mouth syndrome 10.2 IL6 TNF
17 posterior urethral valves 10.2 IL6 TNF
18 mononeuritis of upper limb and mononeuritis multiplex 10.2 MAG MYOM2
19 actinic prurigo 10.2 IL1B TNF
20 jejunoileitis 10.2 IL1B TNF
21 crohn's colitis 10.2 IL1B TNF
22 dental pulp disease 10.2 IL1B TNF
23 congenital cytomegalovirus 10.2 IL1B TNF
24 solitary osseous plasmacytoma 10.2 CD79A MYOM2
25 extramedullary plasmacytoma 10.2 IL6 MYOM2
26 scorpion envenomation 10.2 IL6 TNF
27 recurrent corneal erosion 10.2 IL1B IL6
28 bagassosis 10.2 IL1B IL6
29 exudative glomerulonephritis 10.2 IL1B TNF
30 paraneoplastic syndromes 10.2 IL1B IL6
31 periodontitis, chronic 10.2 IL1B IL6
32 leukomalacia 10.2 IL6 TNF
33 polyclonal hypergammaglobulinemia 10.2 IL6 MYOM2
34 miller fisher syndrome 10.2 MAG TNF
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
36 microscopic colitis 10.2 CD79A TNF
37 critical limb ischemia 10.2 IL6 TNF
38 staphylococcal toxic shock syndrome 10.2 IL1B TNF
39 cardiogenic shock 10.2 IL6 TNF
40 kashin-beck disease 10.2 IL1B TNF
41 null-cell leukemia 10.2 IL6 TNF
42 rheumatoid lung disease 10.2 IL1B TNF
43 retinitis pigmentosa 55 10.2 IL6 TNF
44 uremic pruritus 10.2 IL1B IL6
45 burns 10.1 IL1B TNF
46 anca-associated vasculitis 10.1 IL6 TNF
47 funisitis 10.1 IL1B IL6
48 impetigo 10.1 IL6 MYOM2
49 meningococcemia 10.1 IL1B IL1RN
50 streptococcal toxic-shock syndrome 10.1 IL6 MYOM2 TNF

Graphical network of the top 20 diseases related to Osteosclerotic Myeloma:



Diseases related to Osteosclerotic Myeloma

Symptoms & Phenotypes for Osteosclerotic Myeloma

MGI Mouse Phenotypes related to Osteosclerotic Myeloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 CD79A IL1B IL1RN IL6 MAG PLG
2 cardiovascular system MP:0005385 9.91 IL1B IL1RN IL6 PDGFC PLG TNF
3 homeostasis/metabolism MP:0005376 9.91 CD79A IL1B IL1RN IL6 MAG PDGFC
4 immune system MP:0005387 9.76 CD79A IL1B IL1RN IL6 MAG PLG
5 neoplasm MP:0002006 9.35 CD79A IL1B IL6 PLG TNF
6 nervous system MP:0003631 9.23 CD79A IL1B IL6 MAG PDGFC PLG

Drugs & Therapeutics for Osteosclerotic Myeloma

Search Clinical Trials , NIH Clinical Center for Osteosclerotic Myeloma

Genetic Tests for Osteosclerotic Myeloma

Anatomical Context for Osteosclerotic Myeloma

MalaCards organs/tissues related to Osteosclerotic Myeloma:

41
Bone, B Cells, Lung, Heart, Lymph Node, Eye, Bone Marrow

Publications for Osteosclerotic Myeloma

Articles related to Osteosclerotic Myeloma:

(show all 37)
# Title Authors Year
1
Autoimmune haemolytic anaemia and neuropathy with IgA osteosclerotic myeloma: a case report. ( 28826828 )
2017
2
Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome. ( 27365880 )
2016
3
Circulating plasma cells with Russell bodies in osteosclerotic myeloma. ( 24006527 )
2013
4
Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma. ( 23671753 )
2013
5
Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. ( 22611150 )
2012
6
Osteosclerotic myeloma with POEMS syndrome. ( 20047930 )
2010
7
Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report. ( 16845298 )
2006
8
Polyneuropathy in Osteosclerotic Myeloma Coexisting With Hyaline Vascular Castleman's Disease. ( 19078779 )
2005
9
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. ( 15884463 )
2004
10
CIDP and isolated osteosclerotic myeloma. ( 15623724 )
2004
11
Clinical images: Osteosclerotic myeloma associated with the POEMS syndrome. ( 12124883 )
2002
12
Strontium-89: a novel treatment for a case of osteosclerotic myeloma associated with life-threatening neuropathy. ( 12181052 )
2002
13
Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy. ( 9667789 )
1998
14
Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy. ( 9236797 )
1997
15
Multiple myeloma associated with diffuse osteosclerotic bone lesions: a clinical entity distinct from osteosclerotic myeloma (POEMS syndrome). ( 9395194 )
1997
16
Osteosclerotic myeloma and 'POEMS' syndrome. ( 8813338 )
1996
17
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. A case report. ( 1541970 )
1992
18
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. ( 1953537 )
1991
19
Osteosclerotic myeloma with polyneuropathy and hypocalcemia. ( 2539870 )
1989
20
Case report 572. Osteosclerotic myeloma (POEMS) syndrome. ( 2588035 )
1989
21
Osteosclerotic myeloma variants. ( 3363376 )
1988
22
Successful treatment of peripheral neuropathy with chemotherapy in osteosclerotic myeloma. ( 3039073 )
1987
23
Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. ( 2993255 )
1985
24
Osteosclerotic myeloma complicated by diffuse arteritis, vascular calcification and extensive cutaneous necrosis. ( 3920544 )
1985
25
'Incomplete' pyroglobulin-gamma disease in a patient with osteosclerotic myeloma. ( 6438794 )
1984
26
Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy. ( 6325905 )
1984
27
Melphalan-induced pulmonary fibrosis in osteosclerotic myeloma. ( 6404091 )
1983
28
Osteosclerotic myeloma and peripheral neuropathy. ( 6296727 )
1983
29
Diffuse nonsecretory osteosclerotic myeloma with extensive erythrophagocytosis. ( 6858968 )
1983
30
Osteosclerotic myeloma with polyneuropathy. ( 6254342 )
1980
31
Osteosclerotic myeloma with polyneuropathy and ectopic secretion of calcitonin. ( 203470 )
1978
32
Osteosclerotic myeloma (a case report and review of literature). ( 680785 )
1978
33
Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. ( 559975 )
1977
34
Osteosclerotic myeloma. ( 184307 )
1976
35
Osteosclerotic myeloma with peripheral neuropathy. ( 4371433 )
1974
36
Osteosclerotic myeloma and peripheral neuropathy. A case report. ( 4329504 )
1971
37
The relation between chronic polyneuropathy and osteosclerotic myeloma. ( 6075207 )
1967

Variations for Osteosclerotic Myeloma

Expression for Osteosclerotic Myeloma

Search GEO for disease gene expression data for Osteosclerotic Myeloma.

Pathways for Osteosclerotic Myeloma

Pathways related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 IL1B IL6 PLG TNF
2
Show member pathways
12.58 IL1B IL6 PDGFC TNF
3
Show member pathways
12.47 IL1B IL6 PLG TNF
4 12.43 CD79A IL1B IL1RN TNF
5
Show member pathways
12.19 IL1B IL6 PLG TNF
6
Show member pathways
12.15 IL1B IL6 PDGFC TNF
7 12.12 IL1B IL6 TNF
8
Show member pathways
12.1 IL1B IL6 TNF
9
Show member pathways
12.08 IL1B IL6 TNF
10
Show member pathways
12.06 A2M PLG VWF
11
Show member pathways
12.04 IL1B IL1RN IL6 TNF
12 11.99 IL1B IL1RN IL6 TNF
13 11.98 A2M PLG VWF
14
Show member pathways
11.95 IL1B IL6 TNF
15 11.89 CD79A IL6 TNF
16 11.88 IL1B IL6 TNF
17 11.86 IL1B IL6 TNF
18 11.8 IL1B IL6 TNF
19
Show member pathways
11.79 A2M PLG TNF
20 11.77 IL1B IL6 TNF
21 11.76 IL1B IL6 TNF
22 11.73 IL1B IL6 TNF
23
Show member pathways
11.66 IL1B IL6 PLG TNF
24 11.65 IL1B IL6 TNF
25 11.63 IL1B IL6 TNF
26 11.55 IL1B IL6 TNF
27
Show member pathways
11.54 IL1B IL6 TNF
28 11.54 IL1B IL6 MAG TNF
29 11.46 IL1B IL6 TNF
30 11.4 IL1B IL6 TNF
31 11.38 IL6 PLG TNF
32 11.34 IL1B IL6 TNF
33 11.18 IL1B IL6 TNF
34 11.15 IL1B IL6 TNF
35 11.1 IL1B IL6 TNF
36 11.09 IL1B IL6 TNF
37 11.04 IL1B IL6 TNF
38 11.02 IL1B TNF
39 11.01 IL6 TNF
40 10.96 IL1B IL6 TNF
41 10.95 IL6 TNF
42 10.95 IL1B IL1RN IL6 TNF
43 10.87 A2M IL1B IL1RN IL6 TNF
44 10.86 IL1B TNF

GO Terms for Osteosclerotic Myeloma

Cellular components related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 A2M IL1B IL1RN IL6 PDGFC PLG
2 extracellular region GO:0005576 9.23 A2M IL1B IL1RN IL6 PDGFC PLG
3 platelet alpha granule lumen GO:0031093 9.13 A2M PLG VWF

Biological processes related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 IL1B IL1RN IL6 TNF
2 inflammatory response GO:0006954 9.91 IL1B IL1RN IL6 TNF
3 regulation of signaling receptor activity GO:0010469 9.88 IL1B IL1RN IL6 PDGFC TNF
4 cytokine-mediated signaling pathway GO:0019221 9.87 IL1B IL1RN IL6 TNF
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 IL1B IL1RN TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B IL6 TNF
7 platelet degranulation GO:0002576 9.79 A2M PLG VWF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 IL1B IL6 TNF
9 positive regulation of JNK cascade GO:0046330 9.75 IL1B IL1RN TNF
10 cellular response to lipopolysaccharide GO:0071222 9.71 IL1B IL1RN IL6 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.66 IL1B TNF
12 positive regulation of chemokine production GO:0032722 9.64 IL6 TNF
13 blood coagulation, intrinsic pathway GO:0007597 9.64 A2M VWF
14 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.63 IL1B TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
18 positive regulation of JUN kinase activity GO:0043507 9.61 IL1B IL1RN TNF
19 positive regulation of astrocyte differentiation GO:0048711 9.59 IL1B MAG
20 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
21 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
22 response to glucocorticoid GO:0051384 9.56 IL1B IL1RN IL6 TNF
23 negative regulation of glutamate secretion GO:0014050 9.55 IL1B IL1RN
24 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
25 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6 TNF
26 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.52 IL1RN IL6
27 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
28 positive regulation of glial cell proliferation GO:0060252 9.5 IL1B IL6 TNF
29 sequestering of triglyceride GO:0030730 9.49 IL1B TNF
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
31 positive regulation of interleukin-6 production GO:0032755 9.46 IL1B IL1RN IL6 TNF
32 positive regulation of neuroinflammatory response GO:0150078 9.13 IL1B IL6 TNF
33 chronic inflammatory response to antigenic stimulus GO:0002439 8.8 IL1B IL1RN TNF

Molecular functions related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
2 protease binding GO:0002020 9.13 A2M TNF VWF
3 cytokine activity GO:0005125 8.92 IL1B IL1RN IL6 TNF

Sources for Osteosclerotic Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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