MCID: OST008
MIFTS: 32

Osteosclerotic Myeloma

Categories: Blood diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Osteosclerotic Myeloma

MalaCards integrated aliases for Osteosclerotic Myeloma:

Name: Osteosclerotic Myeloma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9541
SNOMED-CT 67 42215000
UMLS 71 C1510415

Summaries for Osteosclerotic Myeloma

MalaCards based summary : Osteosclerotic Myeloma is related to poems syndrome and chronic polyneuropathy. An important gene associated with Osteosclerotic Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Allograft rejection and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include bone, lung and skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Osteosclerotic Myeloma

Diseases related to Osteosclerotic Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
# Related Disease Score Top Affiliating Genes
1 poems syndrome 32.4 VEGFA MYOM2 IL6 IL1B
2 chronic polyneuropathy 30.4 MAG CD40LG
3 papilledema 29.9 VEGFA MYOM2 CD40LG
4 amyloidosis 29.8 MYOM2 IL6 CD40LG
5 polyneuropathy 29.4 VEGFA MAG IL6 IL1B CD40LG
6 myeloma, multiple 29.2 VEGFA MYOM2 MAEA IL6 CD40LG
7 bone disease 29.2 VEGFA IL6 IL1B
8 plasma cell neoplasm 28.9 VEGFA MYOM2 MAEA IL6 CD40LG
9 peripheral nervous system disease 28.7 VEGFA MYOM2 MAG IL6 IL1B CD40LG
10 neuropathy 10.6
11 asymmetric motor neuropathy 10.3 MYOM2 MAG
12 endosteal hyperostosis, autosomal dominant 10.3
13 non-secretory myeloma 10.3 MYOM2 CD40LG
14 spastic paraplegia 75, autosomal recessive 10.3 MYOM2 MAG
15 heavy chain disease 10.3 MYOM2 CD40LG
16 smoldering myeloma 10.3 MYOM2 CD40LG
17 scarlet fever 10.3 MYOM2 CD40LG
18 alpha chain disease 10.3 MYOM2 CD40LG
19 acute poststreptococcal glomerulonephritis 10.3 MYOM2 CD40LG
20 autoimmune neuropathy 10.3 MAG CD40LG
21 miller fisher syndrome 10.2 MAG CD40LG
22 streptococcal toxic-shock syndrome 10.2 MYOM2 IL6
23 dowling-degos disease 1 10.2
24 hypothyroidism 10.2
25 demyelinating polyneuropathy 10.2
26 autoimmune disease of peripheral nervous system 10.2 MAG CD40LG
27 wallerian degeneration 10.2 VEGFA MAG
28 necrotizing fasciitis 10.2 MYOM2 IL6
29 endocrine exophthalmos 10.2 IL6 CD40LG
30 chorioretinal scar 10.2 VEGFA CD40LG
31 aortitis 10.2 IL6 CD40LG
32 solitary osseous plasmacytoma 10.2 MYOM2 MAEA
33 tenosynovitis 10.2 IL6 CD40LG
34 pyuria 10.2 IL6 CD40LG
35 scleral disease 10.2 IL6 CD40LG
36 lung abscess 10.2 IL6 CD40LG
37 central retinal artery occlusion 10.2 VEGFA CD40LG
38 chlamydia pneumonia 10.2 IL6 CD40LG
39 hantavirus pulmonary syndrome 10.2 VEGFA CD40LG
40 choroiditis 10.2 VEGFA CD40LG
41 iritis 10.2 IL6 CD40LG
42 iridocyclitis 10.2 IL6 CD40LG
43 hydrops, lactic acidosis, and sideroblastic anemia 10.2
44 plasmacytoma 10.2
45 hypertrichosis 10.2
46 polyradiculoneuropathy 10.2
47 fungal meningitis 10.2 IL6 CD40LG
48 vaginal discharge 10.1 IL6 CD40LG
49 trichomoniasis 10.1 IL6 CD40LG
50 epididymis disease 10.1 IL6 CD40LG

Graphical network of the top 20 diseases related to Osteosclerotic Myeloma:



Diseases related to Osteosclerotic Myeloma

Symptoms & Phenotypes for Osteosclerotic Myeloma

MGI Mouse Phenotypes related to Osteosclerotic Myeloma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CD40LG IL1B IL6 MAEA MAG VEGFA
2 immune system MP:0005387 9.43 CD40LG IL1B IL6 MAEA MAG VEGFA
3 integument MP:0010771 9.02 CD40LG IL1B IL6 MAEA VEGFA

Drugs & Therapeutics for Osteosclerotic Myeloma

Search Clinical Trials , NIH Clinical Center for Osteosclerotic Myeloma

Genetic Tests for Osteosclerotic Myeloma

Anatomical Context for Osteosclerotic Myeloma

MalaCards organs/tissues related to Osteosclerotic Myeloma:

40
Bone, Lung, Skin, Kidney, B Cells, Bone Marrow, Eye

Publications for Osteosclerotic Myeloma

Articles related to Osteosclerotic Myeloma:

(show top 50) (show all 112)
# Title Authors PMID Year
1
Osteosclerotic myeloma without features of POEMS syndrome. 61
31407256 2019
2
History, Diagnosis, and Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy. 61
29866282 2018
3
Autoimmune haemolytic anaemia and neuropathy with IgA osteosclerotic myeloma: a case report. 61
28826828 2017
4
Osteolytic-variant POEMS syndrome: an uncommon presentation of "osteosclerotic" myeloma. 61
28343327 2017
5
Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome. 61
27365880 2016
6
POEMS syndrome associated with plasmacytoma of the clivus: "Time discovers the truth". 61
26469713 2016
7
[Chronic kidney disease associated with Poems syndrome: Report of one case]. 61
27401385 2016
8
[Transition to aggressive phase in a multiple myeloma patient with IgH/CCND1 translocation and diffuse osteosclerotic lesions]. 61
27169455 2016
9
The role of radiotherapy in the management of POEMS syndrome. 61
25431020 2014
10
Diagnosis and treatment of chronic acquired demyelinating polyneuropathies. 61
24980070 2014
11
Papilledema as the initial presentation of Castleman disease. 61
24423600 2014
12
Circulating plasma cells with Russell bodies in osteosclerotic myeloma. 61
24006527 2013
13
Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma. 61
23671753 2013
14
[The effect of lenalidomide on rare blood disorders: Langerhans cell histiocytosis, multicentric Castleman disease, POEMS syndrome, Erdheim-Chester disease and angiomatosis]. 61
23256832 2012
15
Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. 61
22611150 2012
16
[Clinical observation of thalidomide combined with VAD regimen for treatment of osteosclerotic myeloma (POEMS syndrome)]. 61
22541096 2012
17
[POEMS syndrome and osteosclerotic myeloma]. 61
22012823 2011
18
[Crow-Fukase syndrome (POEMS syndrome)]. 61
21301037 2011
19
Myelomagenesis: capturing early microenvironment changes. 61
21232654 2011
20
Osteosclerotic myeloma with POEMS syndrome. 61
20047930 2010
21
[POEMS syndrome: a case report]. 61
19406440 2009
22
A case report of POEMS syndrome developing during the clinical course of immune thrombocytopenic purpura. 61
17957571 2007
23
POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin lesions) syndrome: a South America's report. 61
17665027 2007
24
Cytodiagnosis of multiple myeloma presenting as orbital involvement: a case report. 61
16901345 2006
25
Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report. 61
16845298 2006
26
Polyneuropathy in Osteosclerotic Myeloma Coexisting With Hyaline Vascular Castleman's Disease. 61
19078779 2005
27
POEMS Syndrome. 61
16304404 2005
28
CIDP and isolated osteosclerotic myeloma. 61
15623724 2004
29
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. 61
15884463 2004
30
Different clinical, electrophysiological and immunological features of CIDP associated with paraproteinaemia. 61
12956862 2003
31
Immunotherapy of idiopathic inflammatory neuropathies. 61
12929187 2003
32
[Primary amyloidosis associated with osteosclerotic myeloma]. 61
12646089 2003
33
Neuropathies associated with IgG and IgA monoclonal gammopathy. 61
12407307 2002
34
Strontium-89: a novel treatment for a case of osteosclerotic myeloma associated with life-threatening neuropathy. 61
12181052 2002
35
Clinical images: Osteosclerotic myeloma associated with the POEMS syndrome. 61
12124883 2002
36
[A man with plasma cell dyscrasia and polyneuropathy due to POEMS syndrome]. 61
11876037 2002
37
Paraproteinemic Neuropathy. 61
11180752 2001
38
[POEMS syndrome disclosed by ophthalmological manifestation]. 61
11139732 2000
39
Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. 61
10339470 1999
40
A man with worsening weakness. 61
10780192 1999
41
Clinical aspects of multiple myeloma and related disorders including amyloidosis. 61
10192881 1999
42
[POEMS syndrome]. 61
10883513 1999
43
POEMS syndrome with vascular lesions: a role for interleukin-1beta and interleukin-6 increase--a case report. 61
9822051 1998
44
POEMS syndrome with vascular lesions and renal carcinoma - possible role of cytokines. 61
9620893 1998
45
Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy. 61
9667789 1998
46
[A case of polyneuropathy associated with osteosclerotic myeloma]. 61
9711125 1998
47
Pearls and pitfalls in the horror cinema. 61
9608623 1998
48
Multiple myeloma associated with diffuse osteosclerotic bone lesions: a clinical entity distinct from osteosclerotic myeloma (POEMS syndrome). 61
9395194 1997
49
Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy. 61
9236797 1997
50
[POEMS syndrome]. 61
9255373 1997

Variations for Osteosclerotic Myeloma

Expression for Osteosclerotic Myeloma

Search GEO for disease gene expression data for Osteosclerotic Myeloma.

Pathways for Osteosclerotic Myeloma

GO Terms for Osteosclerotic Myeloma

Biological processes related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 VEGFA IL6 IL1B
2 negative regulation of apoptotic process GO:0043066 9.56 VEGFA MAEA IL6 CD40LG
3 positive regulation of cell division GO:0051781 9.52 VEGFA IL1B
4 positive regulation of epithelial to mesenchymal transition GO:0010718 9.51 IL6 IL1B
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.5 IL6 IL1B CD40LG
6 positive regulation of p38MAPK cascade GO:1900745 9.48 VEGFA IL1B
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.46 IL6 IL1B
8 negative regulation of neurogenesis GO:0050768 9.43 IL6 IL1B
9 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.4 VEGFA IL1B
10 positive regulation of glial cell proliferation GO:0060252 9.37 IL6 IL1B
11 positive regulation of neuroinflammatory response GO:0150078 9.16 IL6 IL1B
12 cardiac muscle fiber development GO:0048739 8.96 VEGFA MYOM2
13 positive regulation of T cell proliferation GO:0042102 8.8 IL6 IL1B CD40LG

Molecular functions related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 VEGFA IL6 IL1B CD40LG

Sources for Osteosclerotic Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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