Aliases & Classifications for Otitis Externa

MalaCards integrated aliases for Otitis Externa:

Name: Otitis Externa 12 44 15 73
Swimmer's Ear 12 76
Acute Infective Otitis Externa 73
Infective Otitis Externa 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9463
ICD9CM 35 380.1 380.10
MeSH 44 D010032
NCIt 50 C3299
ICD10 33 H60 H62.4

Summaries for Otitis Externa

Disease Ontology : 12 An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infections.

MalaCards based summary : Otitis Externa, also known as swimmer's ear, is related to otomycosis and malignant otitis externa. An important gene associated with Otitis Externa is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Glioma. The drugs Cipro and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain.

Wikipedia : 76 Otitis externa, also called swimmer\'s ear, is inflammation of the ear canal. It often presents with ear... more...

Related Diseases for Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 otomycosis 31.7 CALM1 CALM2 CALM3
2 malignant otitis externa 12.7
3 chronic fungal otitis externa 12.2
4 beach ear 11.8
5 acute infection of pinna 11.1
6 perichondritis of auricle 11.1
7 otitis media 10.5
8 osteomyelitis 10.4
9 mastoiditis 10.2
10 cholesteatoma of external ear 10.2
11 dermatitis 10.2
12 pyoderma 10.2
13 langerhans cell histiocytosis 10.1
14 cervicitis 10.1
15 contact dermatitis 10.1
16 histiocytosis 10.1
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
18 arthritis 10.0
19 lemierre's syndrome 10.0
20 suppurative otitis media 10.0
21 squamous cell carcinoma 10.0
22 allergic contact dermatitis 10.0
23 cranial nerve palsy 10.0
24 pneumonia 10.0
25 adenoma 10.0
26 septic arthritis 10.0
27 leishmaniasis 10.0
28 myoclonus and ataxia 9.9
29 leukemia, acute lymphoblastic 9.9
30 cutaneous leishmaniasis 9.9
31 leukemia 9.9
32 skin disease 9.9
33 adenoiditis 9.9
34 immunoglobulin alpha deficiency 9.9
35 sensorineural hearing loss 9.9
36 lymphoblastic leukemia 9.9
37 tonsillitis 9.9
38 nasopharyngitis 9.9
39 meningoencephalitis 9.9
40 ecthyma 9.9
41 optic neuritis 9.9
42 myringitis bullosa hemorrhagica 9.9
43 multiple cranial nerve palsy 9.9
44 facial paralysis 9.9
45 papilledema 9.9
46 cholera 9.9
47 cystitis 9.9
48 neuritis 9.9
49 relapsing polychondritis 9.9
50 adenocarcinoma 9.9

Comorbidity relations with Otitis Externa via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Heart Disease
Hypertension, Essential Ischemic Heart Disease
Otitis Media

Graphical network of the top 20 diseases related to Otitis Externa:



Diseases related to Otitis Externa

Symptoms & Phenotypes for Otitis Externa

Drugs & Therapeutics for Otitis Externa

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cipro 18 CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE Bayer June 1997

Drugs for Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 3,Phase 2,Phase 1 85721-33-1 2764
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
3
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
4
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
5 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
6
Iodine Approved, Investigational Phase 3 7553-56-2 807
7
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
8
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
9
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
10
Dipivefrin Approved Phase 3,Phase 2,Phase 1 52365-63-6 3105
11
Povidone-iodine Approved Phase 3 25655-41-8
12
Polyestradiol phosphate Approved Phase 3 28014-46-2
13
Povidone Approved Phase 3 9003-39-8
14
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
15 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
16 glucocorticoids Phase 3,Phase 2
17
protease inhibitors Phase 3,Phase 2
18 Gastrointestinal Agents Phase 3,Phase 2
19 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Phase 2,Phase 1
20 HIV Protease Inhibitors Phase 3,Phase 2
21 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Phase 1
22 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
23 Hormone Antagonists Phase 3,Phase 2
24 Dexamethasone 21-phosphate Phase 3,Phase 2
25 Hormones Phase 3,Phase 2
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
27 Peripheral Nervous System Agents Phase 3,Phase 2
28 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
29 Antibiotics, Antitubercular Phase 3,Phase 2
30 Anti-Infective Agents Phase 3,Phase 2,Phase 1
31 Antiemetics Phase 3,Phase 2
32 Anti-Inflammatory Agents Phase 3,Phase 2
33 BB 1101 Phase 3,Phase 2
34 Autonomic Agents Phase 3,Phase 2
35 Antineoplastic Agents, Hormonal Phase 3,Phase 2
36 cadexomer iodine Phase 3
37 Fluoroquinolones Phase 3
38 Ciprofloxacin, hydrocortisone drug combination Phase 3
39 Contraceptive Agents Phase 3
40 Contraceptives, Oral Phase 3
41 Contraceptives, Oral, Combined Phase 3
42 Cortisol succinate Phase 3
43 Norgestimate, ethinyl estradiol drug combination Phase 3
44 Nucleic Acid Synthesis Inhibitors Phase 3
45 Hydrocortisone 17-butyrate 21-propionate Phase 3
46 Hydrocortisone acetate Phase 3
47 Hydrocortisone-17-butyrate Phase 3
48 Estradiol 17 beta-cypionate Phase 3
49 Estradiol 3-benzoate Phase 3
50 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Comparative Efficacy and Safety of Two Ciprofloxacin 0.3% and Dexamethasone 0.1% Formulations in Subjects With Acute Otitis Externa Unknown status NCT02216071 Phase 3 Ciprodex®;EXL CDOS (Ciprofloxacin 0.3% and Dexamethasone 0.1%) Sterile Otic Suspension
2 Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. Unknown status NCT00967317 Phase 3 Auris-Sedina;Otosynalar®
3 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535560 Phase 3 AL-60371, 0.3% otic suspension;AL-60371 Vehicle
4 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535599 Phase 3 AL-60371, 0.3% Otic Suspension
5 Phase 3 Study of OTO-201 in Acute Otitis Externa Completed NCT02801370 Phase 3 12 mg ciprofloxacin;Sham Control
6 FST-201 in the Treatment of Acute Otitis Externa Completed NCT00961675 Phase 3 FST201 (dexamethasone 0.1% with povidone-iodine 1%);Ciprodex (Ciprofloxacin 0.3%; dexamethasone 0.1% )
7 A Phase III Study of an Otic Formulation in Acute Otitis Externa Completed NCT00750633 Phase 3 Moxidex otic solution;Moxifloxacin otic solution;Dexamethasone phosphate otic solution
8 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Completed NCT00980876 Phase 3 Cipro HC;Ciprofloxacin HCl and Hydrocortisone
9 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa Recruiting NCT03196973 Phase 3 DF289 plus DF277;DF289;DF277
10 A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa Terminated NCT01910155 Phase 3 Ciprofloxacin/Dexamethasone;Ciprodex (R);Placebo
11 FST-201 In The Treatment of Acute Otitis Externa Terminated NCT00945802 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;ciprofloxacin 0.3%, dexamethasone 0.1%
12 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
13 Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R) Unknown status NCT01584271 Phase 2
14 OTO-201 for the Treatment of Otitis Externa Completed NCT02511561 Phase 2 OTO-201 (ciprofloxacin)
15 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
16 A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis Completed NCT01447017 Phase 2 DPK-060;Placebo for DPK-060 ear drops
17 Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa Completed NCT00872209 Phase 1, Phase 2 0.3% Ciprofloxacin Ear Drops;0.3% Ciprofloxacin Foam Otic Cipro
18 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis Completed NCT01157819 Phase 2 0.3% Ciprofloxacin Ear Drops;FoamOtic Cipro
19 Topical Voltaren in Otitis Externa Terminated NCT00523120 Phase 2 diclofenac sodium;dexotc
20 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) Completed NCT02918773 Not Applicable
21 Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations Completed NCT02558738
22 Evaluation of Middle Ear Implantation Completed NCT00451503 Not Applicable

Search NIH Clinical Center for Otitis Externa

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: otitis externa

Genetic Tests for Otitis Externa

Anatomical Context for Otitis Externa

MalaCards organs/tissues related to Otitis Externa:

41
Bone, Skin, Brain, Tonsil, Testes

Publications for Otitis Externa

Articles related to Otitis Externa:

(show top 50) (show all 595)
# Title Authors Year
1
External auditory canal cholesteatoma and benign necrotising otitis externa: clinical study of 95 cases in the Capital Region of Denmark. ( 29888691 )
2018
2
Ceruminous adenoma mimicking otitis externa. ( 29796271 )
2018
3
Imaging in the Diagnosis and Management of Necrotizing Otitis Externa: A Survey of Practice Patterns. ( 29738387 )
2018
4
Malignant Otitis Externa Outcomes: A Study of the University HealthSystem Consortium Database. ( 29962250 )
2018
5
Comparison of clinical outcomes of three different packing materials in the treatment of severe acute otitis externa. ( 29895341 )
2018
6
Necrotising otitis externa in the immunocompetent patient: case series. ( 29173202 )
2018
7
Aviation Fuel Exposure Resulting in Otitis Externa with Vertigo. ( 29921359 )
2018
8
In vitro antimicrobial activity of narasin against common clinical isolates associated with canine otitis externa. ( 29363210 )
2018
9
Otitis externa. ( 29369930 )
2018
10
Seasonal variation of Pseudomonas aeruginosa in culture positive otitis externa in South East England. ( 29976272 )
2018
11
Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance. ( 29429416 )
2018
12
Advanced Imaging Techniques in Skull Base Osteomyelitis Due to Malignant Otitis Externa. ( 29416952 )
2018
13
A case of otitis externa caused by non-01/non-0139 Vibrio cholerae after exposure at a Mediterranean bathing site. ( 29791126 )
2018
14
Optimising the use of otowicks in otitis externa. ( 28693628 )
2017
15
Impact of a terbinafine-florfenicol-betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners. ( 28295766 )
2017
16
Survey of otitis externa in American Cocker Spaniels in Finland. ( 28241842 )
2017
17
Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. ( 28483146 )
2017
18
The treatment of pseudoaneurysms with flow diverters after malignant otitis externa. ( 28992722 )
2017
19
Adenoids in paediatric chronic rhinosinusitis, deep neck space infections and optimising otowicks in otitis externa. ( 28841132 )
2017
20
The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats. ( 29283096 )
2017
21
Contribution of oral triamcinolone to treating proliferative and necrotising otitis externa in a 14-year-old Persian cat. ( 28491450 )
2017
22
A Case of Cutaneous Leishmaniasis guyanensis Mimicking Otitis Externa. ( 28811000 )
2017
23
Otitis externa in military divers: more frequent and less harmful than reported. ( 28357818 )
2017
24
The role of surgery in necrotizing otitis externa. ( 28122107 )
2017
25
Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. ( 28301961 )
2017
26
Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. ( 27806892 )
2017
27
Evaluation of a single-administration ototopical treatment for canine otitis externa: a randomised trial. ( 29177053 )
2017
28
Lyric hearing aid: a rare cause of benign necrotising otitis externa/external ear canal cholesteatoma. ( 29191823 )
2017
29
Langerhans Cell Histiocytosis Presenting as Chronic Otitis Externa. ( 28045847 )
2017
30
Epidemiological study of dogs with otitis externa in Cape Breton, Nova Scotia. ( 28216686 )
2017
31
Antibacterial and Antifungal Activity of Essential Oils against Pathogens Responsible for Otitis Externa in Dogs and Cats. ( 28930236 )
2017
32
Is malignant otitis externa on the increase? A retrospective review of cases. ( 28231368 )
2017
33
Fungal malignant otitis externa. ( 28348261 )
2017
34
Management of Necrotizing Otitis Externa: Our Experience with Forty-Three Patients. ( 29360092 )
2017
35
Comparison of Microbiological Flora in the External Auditory Canal of Normal Ear and an Ear with Acute Otitis Externa. ( 29207743 )
2017
36
Necrotising otitis externa due to Scopulariopsis brevicaulis in a patient without predisposing factors. ( 28473174 )
2017
37
Antibacterial effect of N-acetylcysteine on common canine otitis externa isolates. ( 27122224 )
2016
38
Antimicrobial resistance, integron carriage, and gyrA and gyrB mutations in Pseudomonas aeruginosa isolated from dogs with otitis externa and pyoderma in Brazil. ( 26833540 )
2016
39
Otitis externa lecture online. ( 27770104 )
2016
40
Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy. ( 27570137 )
2016
41
Kit to help owners administer treatment for otitis externa. ( 27450853 )
2016
42
Comparison of Boric Acid and Combination Drug of Polymyxin, Neomycin and Hydrocortisone (polymyxin NH) in the Treatment of Acute Otitis Externa. ( 27630871 )
2016
43
Clinical evaluation of an antiinflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results. ( 26743397 )
2016
44
Is there a real benefit of hyperbaric oxygenotherapy in the treatment of necrotizing otitis externa? ( 28994886 )
2016
45
Treatment for otitis externa in dogs. ( 26966310 )
2016
46
Recurrent malignant otitis externa with multiple cranial nerve involvement: A case report. ( 29648753 )
2016
47
Serum Malassezia-specific IgE in dogs with recurrent Malassezia otitis externa without concurrent skin disease. ( 27288851 )
2016
48
Efficacy of medical grade honey in the management of canine otitis externa - a pilot study. ( 26929137 )
2016
49
Determination of N-acylhomoserine lactones of Pseudomonas aeruginosa in clinical samples from dogs with otitis externa. ( 27756390 )
2016
50
Bacterial Otitis Externa in Patients Attending an ENT Clinic in Babol, North of Iran. ( 27127584 )
2016

Variations for Otitis Externa

Expression for Otitis Externa

Search GEO for disease gene expression data for Otitis Externa.

Pathways for Otitis Externa

Pathways related to Otitis Externa according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CALM1 CALM2 CALM3 DOCK8
2
Show member pathways
12.61 CALM1 CALM2 CALM3
3
Show member pathways
12.58 CALM1 CALM2 CALM3
4
Show member pathways
12.58 CALM1 CALM2 CALM3
5
Show member pathways
12.58 CALM1 CALM2 CALM3
6
Show member pathways
12.57 CALM1 CALM2 CALM3
7
Show member pathways
12.55 CALM1 CALM2 CALM3
8
Show member pathways
12.53 CALM1 CALM2 CALM3
9
Show member pathways
12.52 CALM1 CALM2 CALM3
10
Show member pathways
12.52 CALM1 CALM2 CALM3
11
Show member pathways
12.51 CALM1 CALM2 CALM3
12
Show member pathways
12.47 CALM1 CALM2 CALM3
13
Show member pathways
12.46 CALM1 CALM2 CALM3
14
Show member pathways
12.45 CALM1 CALM2 CALM3
15
Show member pathways
12.44 CALM1 CALM2 CALM3
16
Show member pathways
12.42 CALM1 CALM2 CALM3
17
Show member pathways
12.42 CALM1 CALM2 CALM3
18
Show member pathways
12.41 CALM1 CALM2 CALM3
19
Show member pathways
12.4 CALM1 CALM2 CALM3
20
Show member pathways
12.38 CALM1 CALM2 CALM3
21
Show member pathways
12.33 CALM1 CALM2 CALM3
22
Show member pathways
12.32 CALM1 CALM2 CALM3
23
Show member pathways
12.31 CALM1 CALM2 CALM3
24
Show member pathways
12.3 CALM1 CALM2 CALM3
25
Show member pathways
12.29 CALM1 CALM2 CALM3
26
Show member pathways
12.28 CALM1 CALM2 CALM3
27
Show member pathways
12.27 CALM1 CALM2 CALM3
28 12.25 CALM1 CALM2 CALM3
29
Show member pathways
12.24 CALM1 CALM2 CALM3
30
Show member pathways
12.24 CALM1 CALM2 CALM3
31
Show member pathways
12.22 CALM1 CALM2 CALM3
32
Show member pathways
12.22 CALM1 CALM2 CALM3
33
Show member pathways
12.21 CALM1 CALM2 CALM3
34
Show member pathways
12.19 CALM1 CALM2 CALM3
35
Show member pathways
12.16 CALM1 CALM2 CALM3
36
Show member pathways
12.16 CALM1 CALM2 CALM3
37
Show member pathways
12.15 CALM1 CALM2 CALM3
38
Show member pathways
12.14 CALM1 CALM2 CALM3
39 12.12 CALM1 CALM2 CALM3
40
Show member pathways
12.1 CALM1 CALM2 CALM3
41
Show member pathways
12.1 CALM1 CALM2 CALM3
42
Show member pathways
12.08 CALM1 CALM2 CALM3
43
Show member pathways
12.07 CALM1 CALM2 CALM3
44
Show member pathways
12.06 CALM1 CALM2 CALM3
45 12.05 CALM1 CALM2 CALM3
46
Show member pathways
12.04 CALM1 CALM2 CALM3
47
Show member pathways
12.02 CALM1 CALM2 CALM3
48 11.98 CALM1 CALM2 CALM3
49 11.98 CALM1 CALM2 CALM3
50
Show member pathways
11.94 CALM1 CALM2 CALM3

GO Terms for Otitis Externa

Cellular components related to Otitis Externa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.58 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.54 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Otitis Externa according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
2 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
3 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
4 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
7 positive regulation of protein autophosphorylation GO:0031954 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
12 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.63 CALM1 CALM2 CALM3
13 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
14 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.58 CALM1 CALM2 CALM3
15 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
16 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
17 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
18 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
19 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
20 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otitis Externa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.65 CALM1 CALM2 CALM3
2 protein domain specific binding GO:0019904 9.63 CALM1 CALM2 CALM3
3 ion channel binding GO:0044325 9.58 CALM1 CALM2 CALM3
4 disordered domain specific binding GO:0097718 9.54 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.5 CALM1 CALM2 CALM3
6 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
7 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
8 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
9 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Otitis Externa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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