MCID: OTT001
MIFTS: 39

Otitis Externa

Categories: Ear diseases

Aliases & Classifications for Otitis Externa

MalaCards integrated aliases for Otitis Externa:

Name: Otitis Externa 12 15 17 71 32
Swimmer's Ear 12 74
Acute Infective Otitis Externa 71
Infective Otitis Externa 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9463
ICD9CM 34 380.1 380.10
NCIt 49 C3299
SNOMED-CT 67 3135009 86981007
ICD10 32 H60 H60.9 H62.4
UMLS 71 C0021355 C0029878 C0339759

Summaries for Otitis Externa

Disease Ontology : 12 An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infections.

MalaCards based summary : Otitis Externa, also known as swimmer's ear, is related to otomycosis and cranial nerve palsy. An important gene associated with Otitis Externa is ELANE (Elastase, Neutrophil Expressed). The drugs Norgestimate and Moxifloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and myeloid.

Wikipedia : 74 Otitis externa, also called swimmer's ear, is inflammation of the ear canal. It often presents with ear... more...

Related Diseases for Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 otomycosis 32.2 RHNO1 POLR2B CBSL B4GALNT2
2 cranial nerve palsy 31.1 RHNO1 CRP
3 multiple cranial nerve palsy 31.0 RHNO1 CRP
4 mastoiditis 30.9 DOCK8 DHX37 CRP
5 central retinal artery occlusion 30.4 RHNO1 CRP
6 dermatophytosis 30.1 POLR2B CBSL B4GALNT2
7 exophthalmos 30.1 RHNO1 CRP
8 tinea pedis 30.1 POLR2B B4GALNT2
9 chickenpox 30.0 DOCK8 CRP
10 mucormycosis 29.9 RHNO1 B4GALNT2
11 malignant otitis externa 13.0
12 chronic fungal otitis externa 12.6
13 beach ear 12.1
14 otitis media 11.8
15 acute infection of pinna 11.4
16 perichondritis of auricle 11.4
17 osteomyelitis 10.8
18 facial paralysis 10.6
19 dermatitis 10.6
20 suppurative otitis media 10.6
21 cholesteatoma of external ear 10.5
22 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
23 chronic purulent otitis media 10.5
24 contact dermatitis 10.5
25 cellulitis 10.4
26 cardiac rupture 10.4 ELANE CRP
27 dermatitis, atopic 10.4
28 skin disease 10.4
29 pyoderma 10.4
30 acute maxillary sinusitis 10.3 RHNO1 CRP
31 ethmoid sinusitis 10.3 RHNO1 CRP
32 cholesteatoma of middle ear 10.3
33 allergic contact dermatitis 10.3
34 acquired immunodeficiency syndrome 10.3
35 seborrheic dermatitis 10.3
36 overgrowth syndrome 10.3
37 cavernous sinus thrombosis 10.3 RHNO1 CRP
38 glossopharyngeal nerve disease 10.3 RHNO1 CRP
39 lung abscess 10.3 DOCK8 CRP
40 intracranial sinus thrombosis 10.3 RHNO1 CRP
41 subdural empyema 10.3 RHNO1 CRP
42 orbital cellulitis 10.3 RHNO1 CRP
43 acute orbital inflammation 10.3 RHNO1 CRP
44 cerebritis 10.3 RHNO1 CRP
45 noonan syndrome 8 10.3 POLR2B CBSL
46 langerhans cell histiocytosis 10.3
47 bacterial infectious disease 10.3
48 allergic hypersensitivity disease 10.3
49 histiocytosis 10.3
50 septic arthritis 10.3

Comorbidity relations with Otitis Externa via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Heart Disease
Hypertension, Essential Otitis Media

Graphical network of the top 20 diseases related to Otitis Externa:



Diseases related to Otitis Externa

Symptoms & Phenotypes for Otitis Externa

Drugs & Therapeutics for Otitis Externa

Drugs for Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
2
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
3
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
4
Polyestradiol phosphate Approved Phase 3 28014-46-2
5
carbamide peroxide Approved Phase 3 124-43-6
6
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
7
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
8
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
9
Iodine Approved, Investigational Phase 3 7553-56-2 807
10
Povidone Approved Phase 3 9003-39-8
11
Povidone-iodine Approved Phase 3 25655-41-8
12
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
14
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
15
Dipivefrin Approved Phase 3 52365-63-6 3105
16 Norgestimate, ethinyl estradiol drug combination Phase 3
17 Contraceptive Agents Phase 3
18 Estradiol 17 beta-cypionate Phase 3
19 Dexamethasone 21-phosphate Phase 3
20 Contraceptives, Oral, Combined Phase 3
21 Contraceptives, Oral Phase 3
22 Estradiol 3-benzoate Phase 3
23 Anti-Infective Agents, Local Phase 3
24 Antibiotics, Antitubercular Phase 3
25 Antitubercular Agents Phase 3
26 Hydrocortisone hemisuccinate Phase 3
27 Ciprofloxacin, hydrocortisone drug combination Phase 3
28 Hydrocortisone 17-butyrate 21-propionate Phase 3
29 Hydrocortisone-17-butyrate Phase 3
30 Plasma Substitutes Phase 3
31 Blood Substitutes Phase 3
32 cadexomer iodine Phase 3
33 Pharmaceutical Solutions Phase 3
34 Anti-Infective Agents Phase 3
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Topoisomerase Inhibitors Phase 3
37 Anti-Bacterial Agents Phase 3
38 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
39 Antiemetics Phase 3
40 HIV Protease Inhibitors Phase 3
41 Gastrointestinal Agents Phase 3
42
protease inhibitors Phase 3
43 Hormone Antagonists Phase 3
44 Autonomic Agents Phase 3
45 BB 1101 Phase 3
46 Anti-Inflammatory Agents Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 glucocorticoids Phase 3
49 Hormones Phase 3
50
Antipyrine Approved, Investigational Phase 2 60-80-0 2206

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Active-Controlled, Parallel-Group Study of the Comparative Efficacy and Safety of EXL CDOS in Subjects With Acute Otitis Externa Unknown status NCT02216071 Phase 3 Ciprodex®;EXL CDOS (Ciprofloxacin 0.3% and Dexamethasone 0.1%) Sterile Otic Suspension
2 Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. Unknown status NCT00967317 Phase 3 Auris-Sedina;Otosynalar®
3 A Phase III Study of an Otic Formulation in Acute Otitis Externa Completed NCT00750633 Phase 3 Moxidex otic solution;Moxifloxacin otic solution;Dexamethasone phosphate otic solution
4 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535560 Phase 3 AL-60371, 0.3% otic suspension;AL-60371 Vehicle
5 A Prospective, Randomized, Double-Blind, Sham-Controlled, Multicenter, Phase 3 Study of OTO-201 Given as a Single Administration for Treatment of Acute Otitis Externa Completed NCT02801370 Phase 3 12 mg ciprofloxacin;Sham Control
6 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535599 Phase 3 AL-60371, 0.3% Otic Suspension
7 A Phase III, Multicenter, Randomized, Double-Blind Clinical Trial to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution Compared to DF289 Otic Solution and to DF277 Otic Solution in the Treatment of Acute Otitis Externa (AOE) Completed NCT03196973 Phase 3 DF289 plus DF277;DF289;DF277
8 Multicentric, Double Blind, Randomized, Parallel Comparative Study Between Ciprofloxacin HCl 2 mg/mL + Hydrocortisone 10 mg/mL Ear Suspension and Cipro HC®, for the Assessment of Efficacy and Safety in Patients With Otitis Externa. Completed NCT00980876 Phase 3 Cipro HC;Ciprofloxacin HCl and Hydrocortisone
9 A Phase III Clinical Study Evaluating the Efficacy Of FST-201 Otic Suspension (Foresight Biotherapeutics, Inc.) Vs. Ciprodex Otic Suspension (Alcon Laboratories, Inc.) in Subjects With Acute Otitis Externa Completed NCT00961675 Phase 3 FST201 (dexamethasone 0.1% with povidone-iodine 1%);Ciprodex (Ciprofloxacin 0.3%; dexamethasone 0.1% )
10 A Phase III, Multicenter, Randomized, Double-Blind Clinical Trial to Assess the Efficacy and Safety of SVT-15652 Otic Solution Complared to Placebo for the Treatment of Fungal Otitis Externa (Otomycosis). Not yet recruiting NCT03686397 Phase 3 SVT-15652;Placebo
11 A Phase III, Multicenter, Randomized, Double-Blind Clinical Trial to Assess the Efficacy and Safety of SVT-15652 Otic Solution Compared to Placebo for the Treatment of Fungal Otitis Externa (Otomycosis) Not yet recruiting NCT03686384 Phase 3 SVT-15652;Placebo
12 A Multi-Center, Randomized, Double-Masked, Vehicle-Controlled Clinical Study Evaluating the Efficacy Of FST-201 (Dexamethasone 0.1%) Otic Suspension in Subjects With Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
13 A Randomized, Double-Blind, Placebo-Controlled, Parallel Design, Multiple-Site Study to Evaluate the Clinical Equivalence of Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspension (Par) Compared to CIPRODEX® (Ciprofloxacin 0.3%/Dexamethasone 0.1%) Sterile Otic Suspension (Alcon) in the Treatment of Adults With Acute Bacterial Otitis Externa Terminated NCT01910155 Phase 3 Ciprofloxacin/Dexamethasone;Ciprodex (R);Placebo
14 A Multi-Center, Randomized, Double-Masked Clinical Study Evaluating the Efficacy Of FST-201 (Dexamethasone 0.1%) Otic Suspension (Foresight Biotherapeutics, Inc.) Vs. Ciprodex (Ciprofloxacin 0.3%, Dexamethasone 0.1%) Otic Suspension (Alcon Laboratories, Inc.) in Subjects With Acute Otitis Externa Terminated NCT00945802 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;ciprofloxacin 0.3%, dexamethasone 0.1%
15 Phase II 3 Arm Double Blinded Clinical Study Evaluating the Pain Killing and Healing Time of Botanical Ear Drops, Ear Comfort(TM), in Severe External Ear Infection (AOE) Patients, Compared to Dex-Otic(R) and Otidin(R) Unknown status NCT01584271 Phase 2
16 A 1-Month, Prospective, Multicenter, Open-Label Study of OTO-201 Given as a Single Administration for Treatment of Otitis Externa Completed NCT02511561 Phase 2 OTO-201 (ciprofloxacin)
17 Safety and Efficacy of Once-Daily Dosing of Ciprodexa Otic Foam (Ciprofloxacin 0.3% and Dexamethasone 0.1% Otic Foam) Compared to Twice-Daily Dosing of Ciprodex (0.3% Ciprofloxacin and Dexamethasone 0.1% Otic Suspension) in Patients With Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
18 Bioequivalence of Ciprofloxacin 0.3%: a Randomized, Multicenter, Parallel, Comparative Study on the Safety and Efficacy of Ciprofloxacin 0.3% in a Standard Solution or Foam Solution, in Patients With Acute External Otitis. Completed NCT00872209 Phase 1, Phase 2 0.3% Ciprofloxacin Ear Drops;0.3% Ciprofloxacin Foam Otic Cipro
19 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro (0.3% Ciprofloxacin Otic Foam) Compared to Twice-Daily Dosing of Ciloxan (0.3% Ciprofloxacin Otic Solution) in Patients With Acute External Otitis Completed NCT01157819 Phase 2 0.3% Ciprofloxacin Ear Drops;FoamOtic Cipro
20 A Randomised, Parallel-group, Double-blind, Placebo-controlled Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis Completed NCT01447017 Phase 2 DPK-060;Placebo for DPK-060 ear drops
21 Topical Voltaren as an Alternative Treatment for Otitis Externa Terminated NCT00523120 Phase 2 diclofenac sodium;dexotc
22 Non Interventional Study (NIS): Clinical Investigation for Evaluation of the Safety and Efficacy of Ectoin Ear Spray and Normison Ear Spray in Skin Treatment of Outer Ear Canal Irritations: A Mulitcenter Non Interventional Study Completed NCT02558738
23 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Completed NCT03768635
24 Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients: a Randomized Controlled Trial Completed NCT01547221 clotrimazole;3% Boric acid
25 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) Completed NCT02918773
26 A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of a Probiotic on Recurrent Acute Otitis Media (rAOM) in Children Active, not recruiting NCT03614117

Search NIH Clinical Center for Otitis Externa

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acetic Acid
ACETIC ACID LIQUID
ACETIC ACID,GLACIAL LIQUID
aluminum acetate
ALUMINUM ACETATE TOPICAL POWDER
Benzocaine
BENZOCAINE PWDR
Chloramphenicol sodium succinate

Genetic Tests for Otitis Externa

Anatomical Context for Otitis Externa

MalaCards organs/tissues related to Otitis Externa:

40
Bone, Skin, Myeloid, Testes, Colon, Eye, Brain

Publications for Otitis Externa

Articles related to Otitis Externa:

(show top 50) (show all 1714)
# Title Authors PMID Year
1
Skin Infections and Outpatient Burn Management: Skin Infections in Patients With Diabetes. 61
31995351 2020
2
Candida albicans skull base osteomyelitis due to malignant otitis externa: the role of echinocandin therapy associated with surgical debridement. 61
30981455 2020
3
Otoscopy and aural cytological findings in a population of rescue cats and cases in a referral small animal hospital in England and Wales. 61
30880543 2020
4
Patulous Eustachian tube and palatine defect in a Dachshund with chronic unilateral otitis externa and otitis media. 61
31908074 2020
5
Malignant Otitis Externa is Associated with Diabetes: A Population-Based Case-Control Study. 61
31976744 2020
6
Complete genome sequence of a methicillin-resistant Staphylococcus schleiferi strain from canine otitis externa in Korea. 61
31940690 2020
7
Matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for accurate discrimination of Staphylococcus schleiferi subspecies. 61
31902510 2020
8
Fungal otitis externa and wet ear with mucopurulent should be influencing factors on tympanic membrane closure. 61
31980889 2020
9
A review of thirty-nine patients diagnosed with necrotising otitis externa over three years: Is CT imaging for diagnosis sufficient? 61
31977136 2020
10
The otic microbiota and mycobiota in a referral population of dogs in eastern USA with otitis externa. 61
31960536 2020
11
Antibacterial effect of N-acetylcysteine in combination with antimicrobials on common canine otitis externa bacterial isolates. 61
31670428 2019
12
Occult otitis media in dogs with chronic otitis externa - magnetic resonance imaging and association with otoscopic and cytological findings. 61
31858646 2019
13
Clinical techniques in Veterinary Dermatology: Regional anaesthesia of the canine ear. 61
31515861 2019
14
Extensive Skull Base Osteomyelitis Secondary to Malignant Otitis Externa. 61
30924772 2019
15
Clinical profiling and management outcome of atypical skull base osteomyelitis. 61
31818143 2019
16
Antimicrobial activity of thyme oil, oregano oil, thymol and carvacrol against sensitive and resistant microbial isolates from dogs with otitis externa. 61
31566822 2019
17
Partial vertical ear canal resection in two cats. 61
31793833 2019
18
In vitro antibacterial activity of the manuka essential oil from Leptospermum scoparium combined with Tris-EDTA against Gram-negative bacterial isolates from dogs with otitis externa. 61
31729809 2019
19
The proportion, conditions, and predictors of emergency department visits that can be potentially managed by pharmacists with expanded scope of practice. 61
30545614 2019
20
Antibiotic choice in UK general practice: rates and drivers of potentially inappropriate antibiotic prescribing. 61
31430365 2019
21
Headache in Petrous Apicitis: A Case Report of Chronic Migraine-like Headache Due to Peripheral Pathology. 61
31535370 2019
22
Diagnosis and Antibiotic Management of Otitis Media and Otitis Externa in United States Veterans. 61
31723568 2019
23
Thirty-Day Readmission and Prolonged Length of Stay in Malignant Otitis Externa. 61
31758583 2019
24
Meta-analysis does not support routine traditional nuclear medicine studies for malignant otitis. 61
31750969 2019
25
Single-use treatment for otitis externa. 61
31757904 2019
26
Clinician adherence to the clinical practice guideline: Acute otitis externa. 61
31730729 2019
27
Comparative assessment of genotypic and phenotypic correlates of Staphylococcus pseudintermedius strains isolated from dogs with otitis externa and healthy dogs. 61
31703937 2019
28
Biofilm production by pathogens associated with canine otitis externa, and the antibiofilm activity of ionophores and antimicrobial adjuvants. 61
31503362 2019
29
In vitro antimicrobial activity of narasin and monensin in combination with adjuvants against pathogens associated with canine otitis externa. 61
31710159 2019
30
Combined use of ivermectin, dimethyl sulfoxide, mineral oil and nematophagous fungi to control Rhabditis spp. 61
31630049 2019
31
Antifungal in vitro Activity of Essential Oils against Clinical Isolates of Malassezia pachydermatis from Canine Ears: A Report from a Practice Laboratory. 61
31775141 2019
32
Dogs as reservoir of methicillin resistant coagulase negative staphylococci strains - A possible neglected risk. 61
31283961 2019
33
Otitis externa in eight horses - clinical signs, treatment and prognosis. 61
31218772 2019
34
Stenotrophomonas skull base osteomyelitis presenting as necrotizing otitis externa: Unmasking by CT and MRI-case report and review. 61
31462947 2019
35
Invasive Fungal Carotiditis: A Rare Manifestation of Cranial Invasive Fungal Disease: Case Series and Systematic Review of the Literature. 61
31660355 2019
36
Seasonal Variation Of Acute Otitis Externa Presenting To Ayub Teaching Hospital, Abbottabad. 61
31933313 2019
37
Effective Inexpensive Management of Necrotizing Otitis Externa Is Possible in Resource-Poor Settings. 61
31043072 2019
38
Osteonecrosis of the External Auditory Canal Associated With Oral Sorafenib Therapy: Sorafenib and Temporal Bone Osteonecrosis. 61
31356482 2019
39
Skull base osteomyelitis: factors implicating clinical outcome. 61
30840222 2019
40
[Analysis of the emergency patients of a university ENT hospital]. 61
31242524 2019
41
A Unique Case of Malignant Otitis Externa. 61
31565987 2019
42
Extended palatoplasty as surgical treatment for nasopharyngeal stenosis in six cats. 61
31259420 2019
43
Imaging of temporal bone inflammations in children: a pictorial review. 61
31321462 2019
44
A case of otitis externa caused by Schizophyllum commune: An approach to antimicrobial stewardship using Gram staining of otorrhea in a medical clinic. 61
30905630 2019
45
Otitis Media: Rapid Evidence Review. 61
31524361 2019
46
Incidence and Risk of Various Disorders of the External Ear in Patients With Hearing Aids Treated in ENT Practices in Germany. 61
31335800 2019
47
A population-based time trend study in the incidence of malignant otitis externa. 61
31168932 2019
48
Staphylococcal scarlet fever associated with staphylococcal enterotoxin M in an elderly patient. 61
31096050 2019
49
Oral corticosteroids for painful acute otitis externa (swimmer's ear): A triple-blind randomised controlled trial. 61
31370128 2019
50
Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens. 61
31050849 2019

Variations for Otitis Externa

Expression for Otitis Externa

Search GEO for disease gene expression data for Otitis Externa.

Pathways for Otitis Externa

GO Terms for Otitis Externa

Sources for Otitis Externa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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