Aliases & Classifications for Otitis Externa

MalaCards integrated aliases for Otitis Externa:

Name: Otitis Externa 12 15 73
Swimmer's Ear 12 76
Acute Infective Otitis Externa 73
Infective Otitis Externa 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9463
ICD9CM 35 380.1 380.10
NCIt 50 C3299
SNOMED-CT 68 3135009 86981007
ICD10 33 H60 H62.4

Summaries for Otitis Externa

Disease Ontology : 12 An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infections.

MalaCards based summary : Otitis Externa, also known as swimmer's ear, is related to otomycosis and malignant otitis externa. An important gene associated with Otitis Externa is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and MAPK-Erk Pathway. The drugs Cipro and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain.

Wikipedia : 76 Otitis externa, also called swimmer''s ear, is inflammation of the ear canal. It often presents with ear... more...

Related Diseases for Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 otomycosis 32.3 CALM1 CALM2 CALM3
2 malignant otitis externa 12.8
3 chronic fungal otitis externa 12.4
4 beach ear 11.9
5 acute infection of pinna 11.3
6 perichondritis of auricle 11.3
7 otitis media 10.7
8 osteomyelitis 10.6
9 mastoiditis 10.4
10 dermatitis 10.4
11 cholesteatoma of external ear 10.4
12 contact dermatitis 10.4
13 pyoderma 10.3
14 langerhans cell histiocytosis 10.3
15 allergic contact dermatitis 10.3
16 histiocytosis 10.3
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
18 arthritis 10.2
19 leukemia 10.2
20 lemierre's syndrome 10.2
21 suppurative otitis media 10.2
22 squamous cell carcinoma 10.2
23 cellulitis 10.2
24 cranial nerve palsy 10.2
25 pneumonia 10.2
26 adenoma 10.2
27 septic arthritis 10.2
28 leishmaniasis 10.2
29 myoclonus and ataxia 10.0
30 temporal arteritis 10.0
31 leukemia, acute lymphoblastic 10.0
32 cutaneous leishmaniasis 10.0
33 skin disease 10.0
34 immunoglobulin alpha deficiency 10.0
35 sensorineural hearing loss 10.0
36 lymphocytic leukemia 10.0
37 tonsillitis 10.0
38 meningoencephalitis 10.0
39 sarcoma 10.0
40 ecthyma 10.0
41 optic neuritis 10.0
42 myringitis bullosa hemorrhagica 10.0
43 multiple cranial nerve palsy 10.0
44 facial paralysis 10.0
45 papilledema 10.0
46 cholera 10.0
47 cystitis 10.0
48 neuritis 10.0
49 relapsing polychondritis 10.0
50 auditory system disease 10.0

Comorbidity relations with Otitis Externa via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Heart Disease
Hypertension, Essential Ischemic Heart Disease
Otitis Media

Graphical network of the top 20 diseases related to Otitis Externa:



Diseases related to Otitis Externa

Symptoms & Phenotypes for Otitis Externa

Drugs & Therapeutics for Otitis Externa

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cipro 18 CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE Bayer June 1997

Drugs for Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2 1177-87-3
2
Ciprofloxacin Approved, Investigational Phase 3,Phase 2,Phase 1 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
4
Dipivefrin Approved Phase 3,Phase 2,Phase 1 52365-63-6 3105
5
Povidone Approved Phase 3 9003-39-8
6
Iodine Approved, Investigational Phase 3 7553-56-2 807
7
Povidone-iodine Approved Phase 3 25655-41-8
8
Polyestradiol phosphate Approved Phase 3 28014-46-2
9
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
10
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
11
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
12
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
13 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
14
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
15
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
16 Gastrointestinal Agents Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 BB 1101 Phase 3,Phase 2
19
protease inhibitors Phase 3,Phase 2
20 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
21 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Phase 1
22 Hormone Antagonists Phase 3,Phase 2
23 Antiemetics Phase 3,Phase 2
24 Hormones Phase 3,Phase 2
25 glucocorticoids Phase 3,Phase 2
26 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Phase 2,Phase 1
27 Autonomic Agents Phase 3,Phase 2
28 Antineoplastic Agents, Hormonal Phase 3,Phase 2
29 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
30 HIV Protease Inhibitors Phase 3,Phase 2
31 Anti-Inflammatory Agents Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 3,Phase 2
33 Anti-Infective Agents Phase 3,Phase 2,Phase 1
34 Dexamethasone 21-phosphate Phase 3,Phase 2
35 Antibiotics, Antitubercular Phase 3,Phase 2
36 cadexomer iodine Phase 3
37 Blood Substitutes Phase 3
38 Anti-Infective Agents, Local Phase 3
39 Plasma Substitutes Phase 3
40 Estradiol 3-benzoate Phase 3
41 Norgestimate, ethinyl estradiol drug combination Phase 3
42 Nucleic Acid Synthesis Inhibitors Phase 3
43 Estradiol 17 beta-cypionate Phase 3
44 Fluoroquinolones Phase 3
45 Contraceptives, Oral Phase 3
46 Contraceptives, Oral, Combined Phase 3
47 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
48 Contraceptive Agents Phase 3
49 Cortisol succinate Phase 3
50 Ciprofloxacin, hydrocortisone drug combination Phase 3

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Comparative Efficacy and Safety of Two Ciprofloxacin 0.3% and Dexamethasone 0.1% Formulations in Subjects With Acute Otitis Externa Unknown status NCT02216071 Phase 3 Ciprodex®;EXL CDOS (Ciprofloxacin 0.3% and Dexamethasone 0.1%) Sterile Otic Suspension
2 Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. Unknown status NCT00967317 Phase 3 Auris-Sedina;Otosynalar®
3 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535560 Phase 3 AL-60371, 0.3% otic suspension;AL-60371 Vehicle
4 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535599 Phase 3 AL-60371, 0.3% Otic Suspension
5 Phase 3 Study of OTO-201 in Acute Otitis Externa Completed NCT02801370 Phase 3 12 mg ciprofloxacin;Sham Control
6 FST-201 in the Treatment of Acute Otitis Externa Completed NCT00961675 Phase 3 FST201 (dexamethasone 0.1% with povidone-iodine 1%);Ciprodex (Ciprofloxacin 0.3%; dexamethasone 0.1% )
7 A Phase III Study of an Otic Formulation in Acute Otitis Externa Completed NCT00750633 Phase 3 Moxidex otic solution;Moxifloxacin otic solution;Dexamethasone phosphate otic solution
8 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Completed NCT00980876 Phase 3 Cipro HC;Ciprofloxacin HCl and Hydrocortisone
9 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa Recruiting NCT03196973 Phase 3 DF289 plus DF277;DF289;DF277
10 SVT-15652 Otic Solution for the Treatment of Otomycosis Not yet recruiting NCT03686384 Phase 3 SVT-15652;Placebo
11 SVT-15652 Otic Solution for the Treatment of Otomycosis. Not yet recruiting NCT03686397 Phase 3 SVT-15652;Placebo
12 A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa Terminated NCT01910155 Phase 3 Ciprofloxacin/Dexamethasone;Ciprodex (R);Placebo
13 FST-201 In The Treatment of Acute Otitis Externa Terminated NCT00945802 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;ciprofloxacin 0.3%, dexamethasone 0.1%
14 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
15 Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R) Unknown status NCT01584271 Phase 2
16 OTO-201 for the Treatment of Otitis Externa Completed NCT02511561 Phase 2 OTO-201 (ciprofloxacin)
17 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
18 A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis Completed NCT01447017 Phase 2 DPK-060;Placebo for DPK-060 ear drops
19 Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa Completed NCT00872209 Phase 1, Phase 2 0.3% Ciprofloxacin Ear Drops;0.3% Ciprofloxacin Foam Otic Cipro
20 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis Completed NCT01157819 Phase 2 0.3% Ciprofloxacin Ear Drops;FoamOtic Cipro
21 Topical Voltaren in Otitis Externa Terminated NCT00523120 Phase 2 diclofenac sodium;dexotc
22 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Reference Center Completed NCT03768635
23 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) Completed NCT02918773 Not Applicable
24 Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations Completed NCT02558738
25 Evaluation of Middle Ear Implantation Completed NCT00451503 Not Applicable

Search NIH Clinical Center for Otitis Externa

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Otitis Externa

Anatomical Context for Otitis Externa

MalaCards organs/tissues related to Otitis Externa:

41
Bone, Skin, Brain, Liver, Testes, Tonsil, Myeloid

Publications for Otitis Externa

Articles related to Otitis Externa:

(show top 50) (show all 810)
# Title Authors Year
1
External auditory canal cholesteatoma and benign necrotising otitis externa: clinical study of 95 cases in the Capital Region of Denmark. ( 29888691 )
2018
2
Ceruminous adenoma mimicking otitis externa. ( 29796271 )
2018
3
Imaging in the Diagnosis and Management of Necrotizing Otitis Externa: A Survey of Practice Patterns. ( 29738387 )
2018
4
Malignant Otitis Externa Outcomes: A Study of the University HealthSystem Consortium Database. ( 29962250 )
2018
5
Comparison of clinical outcomes of three different packing materials in the treatment of severe acute otitis externa. ( 29895341 )
2018
6
Necrotising otitis externa in the immunocompetent patient: case series. ( 29173202 )
2018
7
Aviation Fuel Exposure Resulting in Otitis Externa with Vertigo. ( 29921359 )
2018
8
In vitro antimicrobial activity of narasin against common clinical isolates associated with canine otitis externa. ( 29363210 )
2018
9
Otitis externa. ( 29369930 )
2018
10
Seasonal variation of Pseudomonas aeruginosa in culture positive otitis externa in South East England. ( 29976272 )
2018
11
Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance. ( 29429416 )
2018
12
Advanced Imaging Techniques in Skull Base Osteomyelitis Due to Malignant Otitis Externa. ( 29416952 )
2018
13
A case of otitis externa caused by non-01/non-0139 Vibrio cholerae after exposure at a Mediterranean bathing site. ( 29791126 )
2018
14
Malignant Otitis Externa: A Retrospective Analysis and Treatment Outcomes. ( 30197809 )
2018
15
The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa. ( 30464914 )
2018
16
Complicated Necrotizing Otitis Externa Progressing to Coalescent Mastoiditis and Temporal Lobe Abscess. ( 30367858 )
2018
17
A Lateral Neck Myeloid Sarcoma Presenting as Acute Otitis Externa. ( 30551696 )
2018
18
Diagnosis and treatment of necrotising otitis externa and diabetic foot osteomyelitis - similarities and differences. ( 30149824 )
2018
19
Additive value of 99mTechnetium methylene diphosphonate hybrid single-photon emission computed tomography/computed tomography in the diagnosis of skull base osteomyelitis in otitis externa patients compared to planar bone scintigraphy. ( 30505228 )
2018
20
Necrotising otitis externa due to Scopulariopsis brevicaulis in a patient without predisposing factors. ( 28473174 )
2018
21
Otitis Externa in Secondary Care: A Change in Our Practice Following a Full Cycle Audit. ( 29983763 )
2018
22
In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa. ( 30017076 )
2018
23
Ear canal microbiota - a comparison between healthy dogs and atopic dogs without clinical signs of otitis externa. ( 30084115 )
2018
24
Analysis of the otic mycobiota in dogs with otitis externa compared to healthy individuals. ( 30088292 )
2018
25
Comparison of two ear cytological collection techniques in dogs with otitis externa. ( 30109742 )
2018
26
Use of Systemic Antibiotics for Acute Otitis Externa: Impact of a Clinical Practice Guideline. ( 30124617 )
2018
27
Genetic relationships and population structure of Malassezia pachydermatis strains isolated from dogs with otitis externa and healthy dogs. ( 30130476 )
2018
28
Ciprofloxacin otic suspension (Otiprio) for acute otitis externa. ( 30133425 )
2018
29
A randomized placebo-controlled trial of the efficacy and safety of a terbinafine, florfenicol and betamethasone topical ear formulation in dogs for the treatment of bacterial and/or fungal otitis externa. ( 30170597 )
2018
30
Necrotizing Otitis Externa-Analysis of 83 Cases: Clinical Findings and Course of Disease. ( 30239427 )
2018
31
Ciprofloxacin Otic Suspension (Otiprio) for Acute Otitis Externa. ( 30285176 )
2018
32
The significance of tissue biopsy for fungi in necrotizing otitis externa. ( 30291437 )
2018
33
A randomized, controlled, single-blinded, multicenter evaluation of the efficacy and safety of a once weekly two dose otic gel containing florfenicol, terbinafine and betamethasone administered for the treatment of canine otitis externa. ( 30305092 )
2018
34
Acute otitis externa because of negative pressure wound therapy applied over the head and ear canal for scalping treatment. ( 30379394 )
2018
35
Pseudomonas otitis externa in dogs. ( 30410185 )
2018
36
Necrotizing Otitis Externa. ( 30449798 )
2018
37
In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa. ( 30548715 )
2018
38
Optimising the use of otowicks in otitis externa. ( 28693628 )
2017
39
Impact of a terbinafine-florfenicol-betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners. ( 28295766 )
2017
40
Survey of otitis externa in American Cocker Spaniels in Finland. ( 28241842 )
2017
41
Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. ( 28483146 )
2017
42
The treatment of pseudoaneurysms with flow diverters after malignant otitis externa. ( 28992722 )
2017
43
Adenoids in paediatric chronic rhinosinusitis, deep neck space infections and optimising otowicks in otitis externa. ( 28841132 )
2017
44
The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats. ( 29283096 )
2017
45
Contribution of oral triamcinolone to treating proliferative and necrotising otitis externa in a 14-year-old Persian cat. ( 28491450 )
2017
46
A Case of Cutaneous Leishmaniasis guyanensis Mimicking Otitis Externa. ( 28811000 )
2017
47
Otitis externa in military divers: more frequent and less harmful than reported. ( 28357818 )
2017
48
The role of surgery in necrotizing otitis externa. ( 28122107 )
2017
49
Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. ( 28301961 )
2017
50
Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. ( 27806892 )
2017

Variations for Otitis Externa

Expression for Otitis Externa

Search GEO for disease gene expression data for Otitis Externa.

Pathways for Otitis Externa

Pathways related to Otitis Externa according to GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CALM1 CALM2 CALM3 DOCK8
2
Show member pathways
12.67 CALM1 CALM2 CALM3
3
Show member pathways
12.59 CALM1 CALM2 CALM3
4
Show member pathways
12.59 CALM1 CALM2 CALM3
5
Show member pathways
12.59 CALM1 CALM2 CALM3
6
Show member pathways
12.58 CALM1 CALM2 CALM3
7
Show member pathways
12.56 CALM1 CALM2 CALM3
8
Show member pathways
12.54 CALM1 CALM2 CALM3
9
Show member pathways
12.53 CALM1 CALM2 CALM3
10
Show member pathways
12.53 CALM1 CALM2 CALM3
11
Show member pathways
12.52 CALM1 CALM2 CALM3
12
Show member pathways
12.49 CALM1 CALM2 CALM3
13
Show member pathways
12.48 CALM1 CALM2 CALM3
14
Show member pathways
12.47 CALM1 CALM2 CALM3
15
Show member pathways
12.45 CALM1 CALM2 CALM3
16
Show member pathways
12.43 CALM1 CALM2 CALM3
17
Show member pathways
12.43 CALM1 CALM2 CALM3
18
Show member pathways
12.42 CALM1 CALM2 CALM3
19
Show member pathways
12.4 CALM1 CALM2 CALM3
20
Show member pathways
12.39 CALM1 CALM2 CALM3
21
Show member pathways
12.33 CALM1 CALM2 CALM3
22
Show member pathways
12.33 CALM1 CALM2 CALM3
23
Show member pathways
12.32 CALM1 CALM2 CALM3
24
Show member pathways
12.31 CALM1 CALM2 CALM3
25
Show member pathways
12.31 CALM1 CALM2 CALM3
26
Show member pathways
12.29 CALM1 CALM2 CALM3
27
Show member pathways
12.29 CALM1 CALM2 CALM3
28
Show member pathways
12.28 CALM1 CALM2 CALM3
29 12.26 CALM1 CALM2 CALM3
30
Show member pathways
12.25 CALM1 CALM2 CALM3
31
Show member pathways
12.24 CALM1 CALM2 CALM3
32
Show member pathways
12.23 CALM1 CALM2 CALM3
33
Show member pathways
12.22 CALM1 CALM2 CALM3
34
Show member pathways
12.22 CALM1 CALM2 CALM3
35
Show member pathways
12.21 CALM1 CALM2 CALM3
36
Show member pathways
12.2 CALM1 CALM2 CALM3
37
Show member pathways
12.16 CALM1 CALM2 CALM3
38
Show member pathways
12.16 CALM1 CALM2 CALM3
39
Show member pathways
12.14 CALM1 CALM2 CALM3
40 12.13 CALM1 CALM2 CALM3
41
Show member pathways
12.11 CALM1 CALM2 CALM3
42
Show member pathways
12.11 CALM1 CALM2 CALM3
43
Show member pathways
12.09 CALM1 CALM2 CALM3
44
Show member pathways
12.08 CALM1 CALM2 CALM3
45
Show member pathways
12.06 CALM1 CALM2 CALM3
46 12.06 CALM1 CALM2 CALM3
47
Show member pathways
12.05 CALM1 CALM2 CALM3
48
Show member pathways
12.03 CALM1 CALM2 CALM3
49 11.99 CALM1 CALM2 CALM3
50 11.98 CALM1 CALM2 CALM3

GO Terms for Otitis Externa

Cellular components related to Otitis Externa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.61 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
3 myelin sheath GO:0043209 9.54 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
5 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
6 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
7 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
8 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Otitis Externa according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.77 CALM1 CALM2 CALM3
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
5 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
6 regulation of heart rate GO:0002027 9.72 CALM1 CALM2 CALM3
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 positive regulation of protein autophosphorylation GO:0031954 9.69 CALM1 CALM2 CALM3
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
11 regulation of synaptic vesicle exocytosis GO:2000300 9.65 CALM1 CALM3
12 response to amphetamine GO:0001975 9.65 CALM1 CALM3
13 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
14 activation of adenylate cyclase activity GO:0007190 9.64 CALM1 CALM3
15 positive regulation of DNA binding GO:0043388 9.64 CALM2 CALM3
16 positive regulation of nitric-oxide synthase activity GO:0051000 9.63 CALM1 CALM3
17 response to corticosterone GO:0051412 9.63 CALM1 CALM3
18 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
19 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.62 CALM1 CALM3
20 regulation of synaptic vesicle endocytosis GO:1900242 9.62 CALM1 CALM3
21 establishment of protein localization to membrane GO:0090150 9.61 CALM1 CALM3
22 regulation of high voltage-gated calcium channel activity GO:1901841 9.61 CALM1 CALM3
23 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 establishment of protein localization to mitochondrial membrane GO:0090151 9.56 CALM1 CALM3
26 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
27 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
28 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
29 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
30 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
31 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otitis Externa according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.72 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.65 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.58 CALM1 CALM2 CALM3
4 calcium-dependent protein binding GO:0048306 9.56 CALM1 CALM3
5 enzyme regulator activity GO:0030234 9.54 CALM1 CALM3
6 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
7 phosphatidylinositol 3-kinase binding GO:0043548 9.52 CALM1 CALM3
8 nitric-oxide synthase binding GO:0050998 9.51 CALM1 CALM3
9 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
10 calcium channel inhibitor activity GO:0019855 9.49 CALM1 CALM2
11 nitric-oxide synthase regulator activity GO:0030235 9.46 CALM1 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.43 CALM1 CALM3
13 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
14 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
15 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
16 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Otitis Externa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....