Aliases & Classifications for Otitis Media

MalaCards integrated aliases for Otitis Media:

Name: Otitis Media 57 12 29 55 3 44 15 73
Otitis Media, Susceptibility to 57 13
Otitis Media, Chronic/recurrent 57
Infectious Otitis Media 73
Come/rom 57
Oms 57

Characteristics:

OMIM:

57
Inheritance:
familial predisposition


HPO:

32
otitis media:
Inheritance familial predisposition


Classifications:



External Ids:

OMIM 57 166760
Disease Ontology 12 DOID:10754
ICD10 33 H66.9 H66.90
ICD9CM 35 382.9
MeSH 44 D010033
NCIt 50 C34885
MedGen 42 C1833692

Summaries for Otitis Media

Disease Ontology : 12 A otitis which involves inflammation of the middle ear.

MalaCards based summary : Otitis Media, also known as otitis media, susceptibility to, is related to suppurative otitis media and haemophilus influenzae. An important gene associated with Otitis Media is OMS (Otitis Media, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cedax and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include tonsil, bone and testes, and related phenotypes are recurrent otitis media and hematopoietic system

Wikipedia : 76 Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis... more...

Description from OMIM: 166760

Related Diseases for Otitis Media

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 497)
# Related Disease Score Top Affiliating Genes
1 suppurative otitis media 33.7 CD40LG IL1B TLR2 TLR4
2 haemophilus influenzae 31.5 CXCL8 IL1B TLR2 TNF
3 mycobacterium abscessus 31.2 CXCL8 TLR2 TNF
4 mycobacterium fortuitum 31.2 CXCL8 LACTB
5 mycobacterium chelonae 31.1 CXCL8 TLR2
6 septic arthritis 30.9 CXCL8 TLR2 TLR4
7 osteomyelitis 30.9 CXCL8 IL1B IL6 TNF
8 fasciitis 30.8 CXCL8 IL6 TNF
9 tonsillitis 30.7 CD79A CXCL8 IL1B IL6 TNF
10 wegener granulomatosis 30.6 CXCL8 IL10 IL6 TNF
11 common cold 30.6 CCL11 CXCL8 RNASE3
12 rhinitis 30.5 CCL11 CXCL8 IGHE RNASE3
13 aseptic meningitis 30.4 CXCL8 IL10 IL1B TNF
14 arthritis 30.3 CXCL8 IL10 IL1B IL6 TNF
15 cytomegalovirus infection 30.3 CXCL8 IL10 IL6 TNF
16 conjunctivitis 30.2 CCL11 CXCL8 IL6 RNASE3
17 chorioamnionitis 30.1 CXCL8 IL1B IL6 TLR4 TNF
18 listeriosis 30.1 IL10 IL6 MBL2 TNF
19 lymphadenitis 30.0 CXCL8 IL10 IL1B TLR4 TNF
20 helicobacter pylori infection 30.0 CXCL8 IL10 IL1B TLR4 TNF
21 appendicitis 30.0 CXCL8 IL10 IL1B IL6 TNF
22 reactive arthritis 30.0 CD79A IL10 IL6 TNF
23 allergic rhinitis 29.9 CCL11 CXCL8 IGHE IL10 RNASE3
24 streptococcal meningitis 29.9 CD40LG MBL2 TNF
25 crohn's disease 29.9 IL10 IL1B IL6 TLR4 TNF
26 extrapulmonary tuberculosis 29.9 IL10 IL1B MBL2 TLR2
27 keratoconjunctivitis sicca 29.7 CD79A IL10 IL1B IL6 TNF
28 meningoencephalitis 29.5 CD40LG CD79A IL6
29 pneumocystosis 29.4 CD40LG CD79A TNF
30 bacterial meningitis 29.4 CXCL8 IL10 IL1B IL6 TLR2 TNF
31 peritonitis 29.4 CXCL8 IL10 IL1B IL6 TLR2 TNF
32 keratoconjunctivitis 29.3 CCL11 CD79A CXCL8 RNASE3 TNF
33 churg-strauss syndrome 29.2 CD40LG IL10 RNASE3 TNF
34 lyme disease 28.9 CD40LG IL1B IL6 TLR2 TNF
35 inflammatory bowel disease 28.1 CCL11 CXCL8 IL10 IL1B IL6 TLR2
36 meningitis 27.9 CD40LG CXCL8 IL10 IL1B IL6 LACTB
37 bronchitis 27.8 CCL11 CD40LG CD79A CXCL8 RNASE3 TNF
38 middle ear disease 26.9 A2ML1 CD40LG CD79A CXCL8 FBXO11 IL1B
39 pneumonia 26.4 CCL11 CD40LG CXCL8 IL10 IL1B IL6
40 bronchiolitis 26.2 CCL11 CD40LG CXCL8 IGHE IL10 IL6
41 asthma 25.8 CCL11 CD40LG CD79A CXCL8 IGHE IL10
42 acute serous otitis media 12.6
43 non-suppurative otitis media 12.6
44 chronic purulent otitis media 12.6
45 purulent acute otitis media 12.5
46 chronic tubotympanic suppurative otitis media 12.5
47 acute allergic serous otitis media 12.4
48 acute sanguinous otitis media 12.4
49 acute allergic sanguinous otitis media 12.4
50 adhesive otitis media 12.3

Comorbidity relations with Otitis Media via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Bronchitis
Cholesteatoma of Middle Ear Chronic Myocardial Ischemia
Deficiency Anemia Heart Disease
Hypertension, Essential Labyrinthitis
Mastoiditis Otitis Externa
Pneumococcal Meningitis

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to Otitis Media

Symptoms & Phenotypes for Otitis Media

Symptoms via clinical synopsis from OMIM:

57
Ears:
susceptibility to otitis media


Clinical features from OMIM:

166760

Human phenotypes related to Otitis Media:

32
# Description HPO Frequency HPO Source Accession
1 recurrent otitis media 32 HP:0000403

MGI Mouse Phenotypes related to Otitis Media:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 TNF IL1B IL6 MBL2 CCL11 CD40LG
2 homeostasis/metabolism MP:0005376 10.03 TNF IL1B IL6 MBL2 MUC5AC CD40LG
3 immune system MP:0005387 9.97 IL1B IL6 MBL2 CCL11 CD40LG MUC5AC
4 integument MP:0010771 9.56 TNF IL1B IL6 CD40LG TLR2 FBXO11
5 neoplasm MP:0002006 9.17 TNF IL1B IL6 CD79A TLR2 TLR4

Drugs & Therapeutics for Otitis Media

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cedax 18 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 255)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
2
Halofantrine Approved Phase 4 69756-53-2 37393
3
Montelukast Approved Phase 4,Phase 3,Not Applicable 158966-92-8 5281040
4
Dexlansoprazole Approved, Investigational Phase 4,Not Applicable 138530-94-6, 103577-45-3 9578005
5
Lansoprazole Approved, Investigational Phase 4,Not Applicable 103577-45-3 3883
6
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
7
Cefdinir Approved Phase 4,Phase 2,Phase 3 91832-40-5 6915944
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 437-38-7 3345
9
Morphine Approved, Investigational Phase 4 57-27-2 5288826
10
Oseltamivir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 204255-11-8, 196618-13-0 65028
11
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
12
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
13
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
15
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
16
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
17 Strawberry Approved, Nutraceutical Phase 4
18
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
19
BCG vaccine Investigational Phase 4
20 Andrographolide Investigational Phase 4 5508-58-7
21 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Clavulanic Acid Phase 4,Phase 3,Phase 2,Not Applicable
26 Anti-Asthmatic Agents Phase 4,Not Applicable
27 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
28 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Leukotriene Antagonists Phase 4,Not Applicable
31 Respiratory System Agents Phase 4,Not Applicable
32 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
33 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
34 Anesthetics, General Phase 4,Phase 2,Phase 3,Not Applicable
35 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Vaccines Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Antitubercular Agents Phase 4,Phase 3,Phase 1,Not Applicable
39 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
40 Platelet Aggregation Inhibitors Phase 4,Not Applicable
41 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Protective Agents Phase 4,Phase 3,Phase 1,Not Applicable
43 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
44 Fluoroquinolones Phase 4,Phase 3,Phase 2,Phase 1
45 Antibiotics, Antitubercular Phase 4,Phase 3,Not Applicable
46 Antacids Phase 4,Not Applicable
47 Anti-Ulcer Agents Phase 4,Not Applicable
48 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
49 Proton Pump Inhibitors Phase 4,Not Applicable
50 Cephalosporins Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 305)
# Name Status NCT ID Phase Drugs
1 Amoxicillin Clavulanate in Treatment of Acute Otitis Media Unknown status NCT00299455 Phase 4 amoxicillin-clavulanate;Placebo
2 The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children Unknown status NCT00393159 Phase 4
3 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
4 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children Completed NCT00189462 Phase 4 Montelukast
5 Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children Completed NCT00539149 Phase 4 Amoxycillin;Placebo equivalent to amoxycillin
6 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
7 A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media Completed NCT00645112 Phase 4 cefdinir (Omnicef);azithromycin
8 A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media Completed NCT00644943 Phase 4 cefdinir (Omnicef);amoxicillin
9 Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy Completed NCT01244126 Phase 4 Intranasal fentanyl;morphine IM;IV morphine
10 Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) Completed NCT00419380 Phase 4 dornase alfa (Pulmozyme®)
11 Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age Completed NCT00593502 Phase 4 oseltamivir;placebo
12 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
13 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) Completed NCT01800747 Phase 4
14 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
15 Hutterite Influenza Prevention Study Completed NCT00877396 Phase 4
16 A Study to Evaluate the Safety of HIN1 Monovalent Vaccine (MEDI3414) in Children 2 to 17 Years of Age Completed NCT00946101 Phase 4
17 A Study to Evaluate the Safety of H1N1 Monovalent Vaccine (MEDI3414) in Healthy Adults Completed NCT00945893 Phase 4
18 Live Versus Inactivated Influenza Vaccine Study in Hutterite Children Completed NCT01653015 Phase 4
19 Clinical Trial of Clinical Efficiency and Safety of Ergoferon in Treatment of Influenza Completed NCT01804946 Phase 4 Ergoferon;Oseltamivir
20 Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children Recruiting NCT02935374 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate;Macrolide
21 Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children Recruiting NCT02653742 Phase 4 Ketorolac;Fentanyl
22 Group A Pharyngitis in Children: The GASPARD Study Recruiting NCT03264911 Phase 4 Amoxicillin or Placebo
23 A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis Recruiting NCT03132610 Phase 4 andrographolide sulfonate;andrographolide sulfonate simulation
24 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis Recruiting NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
25 The Benefit and Harm of Fever Suppression by Antipyretics in Influenza Recruiting NCT01891084 Phase 4 Paracetamol;Placebo;Backup NSAID ibuprofen
26 Pneumococcal Vaccines Early and in Combination Active, not recruiting NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
27 Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life Enrolling by invitation NCT01735084 Phase 4
28 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
29 Otiprio Versus Ciprodex Tympanostomy Tube Outcomes Not yet recruiting NCT03347461 Phase 4 Otiprio;Ciprodex
30 A Study of Tamiflu (Oseltamivir) for Treatment of Influenza With a Focus on (H1N1) 2009 Flu Strain Terminated NCT01032837 Phase 4 Oseltamivir;Oseltamivir;Placebo
31 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
32 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
33 Preventing Early Childhood Caries in Indigenous Children: the Baby Teeth Talk Study Unknown status NCT02151916 Phase 3
34 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Unknown status NCT01619462 Phase 3
35 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children Completed NCT01044030 Phase 3 Xylitol syrup;Placebo
36 Improving Otitis Media Care With Clinical Decision Support Completed NCT00581711 Phase 3
37 Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Completed NCT02858388 Phase 3
38 Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence Completed NCT02345447 Phase 3 Herbal-based medication;Placebo
39 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes Completed NCT02600559 Phase 3 OTO-201 (ciprofloxacin)
40 Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children Completed NCT00781521 Phase 3 ofloxacin otic solution 0.3%
41 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00578474 Phase 3 Moxidex otic solution;Ofloxacin otic solution
42 Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children Completed NCT02541760 Phase 3 Monteleukast;Mometasone
43 Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media Completed NCT00638534 Phase 3 Telithromycin (HMR3647)
44 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Completed NCT02044341 Phase 3 AR01;Glycerin ear drops
45 Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes Completed NCT00378417 Phase 3
46 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) Completed NCT02432105 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
47 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 Completed NCT02436304 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
48 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00579189 Phase 3 Moxidex otic solution;Moxifloxacin otic solution
49 Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children Completed NCT03116737 Phase 3 Benzocaine Otic Solution;Placebo
50 Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry Completed NCT01244581 Phase 3 Amoxicillin-clavulanate;Placebo

Search NIH Clinical Center for Otitis Media

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: otitis media

Genetic Tests for Otitis Media

Genetic tests related to Otitis Media:

# Genetic test Affiliating Genes
1 Otitis Media 29

Anatomical Context for Otitis Media

MalaCards organs/tissues related to Otitis Media:

41
Tonsil, Bone, Testes, Lung, Brain, Neutrophil, Colon

Publications for Otitis Media

Articles related to Otitis Media:

(show top 50) (show all 1690)
# Title Authors Year
1
Clinical role of vitamin D in prognosis of otitis media with effusion. ( 29447793 )
2018
2
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
3
To Evaluate and Compare the Result of Ossiculoplasty Using Different Types of Graft Materials and Prosthesis in Cases of Ossicular Discontinuity in Chronic Suppurative Otitis Media Cases. ( 29456937 )
2018
4
In vivo detection of nanometer-scale structural changes of the human tympanic membrane in otitis media. ( 29884809 )
2018
5
Otitis Media with Effusion (OME) in Urban Pediatric Population in a Tertiary Care Centre: A Clinical Study. ( 29977853 )
2018
6
A pilot study to investigate the therapeutic effect of Valsalva maneuver on otitis media with effusion in adults. ( 29914826 )
2018
7
Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media. ( 29073815 )
2018
8
Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. ( 29322750 )
2018
9
The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. ( 29951099 )
2018
10
Air Pollution and Otitis Media in Children: A Systematic Review of Literature. ( 29401661 )
2018
11
Ambulatory Visits for Otitis Media before and after the Introduction of Pneumococcal Conjugate Vaccination. ( 29958675 )
2018
12
The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis. ( 29885746 )
2018
13
No evidence of cholesteatoma in untreated otitis media with effusion in children with primary ciliary dyskinesia. ( 29447810 )
2018
14
Response to comment: Eustachian tube diameter: Is it associated with chronic otitis media development? ( 29426733 )
2018
15
Group A streptococcus acute otitis media progressing to neuroinvasive disease in adults. ( 29942780 )
2018
16
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
17
Pneumococcal phenotype and interaction with nontypeable<i>Haemophilus influenzae</i>as determinants of otitis media progression. ( 29378791 )
2018
18
The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. ( 29888693 )
2018
19
The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1I^, IL-1RA Is Favorably Associated With Chronic Otitis Media. ( 29433161 )
2018
20
International consensus (ICON) on management of otitis media with effusion in children. ( 29398506 )
2018
21
Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. ( 29671212 )
2018
22
Risk of childhood otitis media with focus on potentially modifiable factors: A Danish follow-up cohort study. ( 29447878 )
2018
23
Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control. ( 29415741 )
2018
24
Development of an ear cap in chronic suppurative otitis media using additive manufacturing and TRIZ. ( 29916767 )
2018
25
Air pollution influences the incidence of otitis media in children: A national population-based study. ( 29953484 )
2018
26
Anatomical anomalies of the Eustachian tube and chronic otitis media. ( 29395282 )
2018
27
Optimal control of asthma improved eosinophilic otitis media. ( 29423372 )
2018
28
Tympanostomy tubes for serous otitis media and risk of recurrences. ( 29447881 )
2018
29
The Impact of Clinical Pathways on Antibiotic Prescribing for Acute Otitis Media and Pharyngitis in the Emergency Department. ( 29561517 )
2018
30
Successful treatment of eosinophilic otitis media associated with severe bronchial asthma with an anti-IL-5 monoclonal antibody, mepolizumab. ( 29909018 )
2018
31
Meningitis as a consequence of otitis media in a child referred from the newborn hearing screening programme: A missed opportunity. ( 29427298 )
2018
32
Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model. ( 29449589 )
2018
33
Aerobic bacteria associated with chronic suppurative otitis media in Angola. ( 29720274 )
2018
34
Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats. ( 29947185 )
2018
35
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
36
Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma. ( 29681564 )
2018
37
Prevalence of otitis media and risk-factors for sensorineural hearing loss among infants attending Child Welfare Clinics in the Solomon Islands. ( 29958609 )
2018
38
Genetic counseling in an indigenous Filipino community with a high prevalence of A2ML1-related otitis media. ( 29949068 )
2018
39
Neurological Complications of Acute and Chronic Otitis Media. ( 29445883 )
2018
40
Intracochlear Pressures in Simulated Otitis Media With Effusion: A Temporal Bone Study. ( 29912830 )
2018
41
Innovative Use of Tympanometry and Scintigraphy in Preoperative Assessment of the Patients with Chronic Otitis Media. ( 29977845 )
2018
42
Factors affecting the outcome of adenoidectomy in children treated for chronic otitis media with effusion. ( 29426724 )
2018
43
Gradenigo Syndrome Induced by Suppurative Otitis Media. ( 29894453 )
2018
44
Agreement between diagnoses of otitis media by audiologists and otolaryngologists in Aboriginal Australian children. ( 29954312 )
2018
45
Development and Administration of Chronic Suppurative Otitis Media Questionnaire-12 (COMQ-12) and Chronic Otitis Media Outcome Test-15 (COMOT-15) in Kannada. ( 29619096 )
2018
46
Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children. ( 29395516 )
2018
47
Management of Chronic Suppurative Otitis Media and Otosclerosis in Developing Countries. ( 29525390 )
2018
48
Effects of salso-bromo-iodine thermal water in children suffering from otitis media with effusion: a randomized controlled pilot study. ( 29446785 )
2018
49
Cochlear Implantation in Chronic Otitis Media With Cholesteatoma and Open Cavities: Long-term Surgical Outcomes. ( 29227448 )
2018
50
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018

Variations for Otitis Media

Expression for Otitis Media

LifeMap Discovery
Genes differentially expressed in tissues of Otitis Media patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PNLIPRP3 pancreatic lipase-related protein 3 Blood - 6.47 0.003
2 FAM20A family with sequence similarity 20, member A Blood + 3.09 0.015
Search GEO for disease gene expression data for Otitis Media.

Pathways for Otitis Media

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL11 CD40LG CD79A CXCL8 IGHE IL10
2
Show member pathways
13.46 CCL11 CD40LG CXCL8 IL10 IL1B IL6
3
Show member pathways
13.4 CCL11 CD40LG CXCL8 IGHE IL10 IL1B
4
Show member pathways
13.32 CCL11 CD40LG CXCL8 IL10 IL1B IL6
5
Show member pathways
13.07 CXCL8 IL10 IL1B IL6 MBL2 TLR2
6
Show member pathways
12.93 CCL11 CD40LG CXCL8 IL10 IL1B IL6
7
Show member pathways
12.84 CXCL8 IL1B IL6 TLR2 TLR4 TNF
8
Show member pathways
12.78 CXCL8 IL1B IL6 TLR4 TNF
9
Show member pathways
12.76 CD40LG IL1B IL6 TLR2 TLR4 TNF
10
Show member pathways
12.68 CXCL8 IL10 IL1B IL6 TNF
11 12.62 CD40LG CD79A IL10 IL1B TLR2 TNF
12
Show member pathways
12.61 CXCL8 IL6 TLR2 TLR4 TNF
13
Show member pathways
12.58 CD40LG IL1B TLR2 TLR4 TNF
14
Show member pathways
12.52 IL10 IL1B IL6 TLR2 TLR4 TNF
15
Show member pathways
12.48 CD40LG IL10 IL1B IL6 TNF
16
Show member pathways
12.34 CXCL8 IL1B IL6 TLR4 TNF
17
Show member pathways
12.33 CXCL8 IL6 TLR2 TLR4 TNF
18
Show member pathways
12.32 IL10 IL1B IL6 TLR2 TLR4 TNF
19
Show member pathways
12.31 CD40LG IL10 IL1B TLR2 TLR4 TNF
20 12.27 IL10 IL1B IL6 TLR2 TLR4 TNF
21
Show member pathways
12.25 CXCL8 IL1B IL6 MUC5AC MUC5B TLR2
22
Show member pathways
12.24 IL10 IL1B IL6 TNF
23 12.24 CXCL8 IL10 IL1B IL6 TNF
24 12.22 IL6 TLR2 TLR4 TNF
25
Show member pathways
12.19 CCL11 CXCL8 IL1B IL6 TLR2 TLR4
26
Show member pathways
12.19 CCL11 CXCL8 IL1B IL6 MUC5AC MUC5B
27
Show member pathways
12.12 CCL11 CXCL8 IL10 IL1B IL6
28 12.08 CXCL8 IL1B IL6 TLR4 TNF
29 12.05 CD79A IL10 IL6 TNF
30 11.97 CXCL8 IL1B IL6 TNF
31 11.96 CD40LG CXCL8 IL1B TLR4 TNF
32 11.91 CXCL8 IL1B IL6 TLR2 TLR4 TNF
33 11.9 CXCL8 IL1B IL6 TLR4
34 11.82 IL10 IL1B IL6 TNF
35 11.79 IL10 IL1B TNF
36
Show member pathways
11.77 CD40LG CXCL8 TNF
37 11.76 CXCL8 IL10 IL1B IL6 TLR4 TNF
38 11.76 CCL11 CXCL8 IGHE IL10 IL1B IL6
39 11.74 CCL11 CD40LG IGHE IL10
40
Show member pathways
11.72 CD40LG CXCL8 IL1B IL6 TNF
41 11.64 CCL11 CXCL8 IL1B IL6 MUC5B TNF
42 11.6 IL1B TLR2 TLR4 TNF
43 11.6 CXCL8 IL10 IL1B IL6 TNF
44 11.55 CCL11 CXCL8 IL6
45 11.54 CXCL8 IL1B IL6 TLR2 TLR4 TNF
46 11.53 IL1B IL6 TNF
47 11.48 CXCL8 IL10 IL1B IL6 TLR2 TLR4
48 11.44 IL10 IL1B IL6 TNF
49 11.44 IL10 IL1B IL6 TLR4 TNF
50 11.37 IL1B IL6 TNF

GO Terms for Otitis Media

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 A2ML1 CCL11 CD40LG CXCL8 IGHE IL10
2 external side of plasma membrane GO:0009897 9.55 CD40LG CD79A IGHE TLR4 TNF
3 extracellular space GO:0005615 9.4 A2ML1 CCL11 CD40LG CXCL8 IL10 IL1B

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 CXCL8 IL10 IL1B TLR2 TLR4
2 defense response to bacterium GO:0042742 9.95 IGHE IL10 MBL2 RNASE3 TLR4 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.92 CXCL8 IL10 IL6 TLR4 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.91 CCL11 CXCL8 IGHE IL10 IL1B IL6
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.9 IL10 IL1B IL6 TNF
6 B cell differentiation GO:0030183 9.87 CD40LG CD79A IL10
7 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
8 neutrophil chemotaxis GO:0030593 9.86 CCL11 CXCL8 IL1B
9 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
10 positive regulation of T cell proliferation GO:0042102 9.85 CD40LG IL1B IL6
11 defense response to Gram-positive bacterium GO:0050830 9.85 IL6 MBL2 RNASE3 TLR2 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.81 IL1B TLR4 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B TLR4 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL1B TLR2 TLR4 TNF
15 positive regulation of phagocytosis GO:0050766 9.8 IL1B MBL2 TNF
16 B cell proliferation GO:0042100 9.78 CD40LG CD79A IL10
17 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR4 TNF
18 positive regulation of interleukin-12 production GO:0032735 9.76 CD40LG TLR2 TLR4
19 positive regulation of interleukin-10 production GO:0032733 9.75 CD40LG TLR2 TLR4
20 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 MBL2 TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
22 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CD40LG IL1B IL6 TLR2 TLR4 TNF
23 response to molecule of bacterial origin GO:0002237 9.72 CXCL8 IL10 TLR2
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
25 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TLR4 TNF
26 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
27 regulation of cytokine secretion GO:0050707 9.7 TLR2 TLR4
28 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
29 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
30 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
32 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 TLR4
34 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
36 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
37 regulation of immunoglobulin secretion GO:0051023 9.64 CD40LG TNF
38 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
39 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
40 positive regulation of chemokine production GO:0032722 9.62 IL6 TLR2 TLR4 TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
42 inflammatory response GO:0006954 9.61 CCL11 CD40LG CXCL8 IL10 IL1B IL6
43 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B IL6 TLR2 TLR4 TNF
44 immune response GO:0006955 9.32 CCL11 CD40LG CXCL8 IGHE IL10 IL1B
45 positive regulation of transcription by RNA polymerase II GO:0045944 10.2 IL10 IL1B IL6 SHOX TLR2 TLR4
46 negative regulation of cell proliferation GO:0008285 10.08 CXCL8 IL10 IL1B IL6 TLR2
47 positive regulation of gene expression GO:0010628 10.05 IL1B IL6 TLR2 TLR4 TNF
48 regulation of signaling receptor activity GO:0010469 10.04 CCL11 CD40LG CXCL8 IL10 IL1B IL6

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 CD40LG CXCL8 IL10 IL1B IL6
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
3 lipopolysaccharide binding GO:0001530 9.13 RNASE3 TLR2 TLR4

Sources for Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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