Otitis Media disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

OM MCID: OTT002 MIFTS: 68	Otitis Media (OM) Categories: Ear diseases, Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Otitis Media

MalaCards integrated aliases for Otitis Media:

Name: Otitis Media ⁵⁷ ¹² ⁷⁵ ²⁹ ⁵⁵ ³ ⁴⁴ ¹⁵ ⁷³

Otitis Media, Susceptibility to ⁵⁷ ¹³ ⁶

Otitis Media, Chronic/recurrent ⁵⁷ ⁷⁵

Come/rom ⁵⁷ ⁷⁵

Oms ⁵⁷ ⁷⁵

Infectious Otitis Media ⁷³

Om ⁷⁵

Characteristics:

OMIM:

⁵⁷

Inheritance:
familial predisposition

HPO:

³²

otitis media:
Inheritance polygenic inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Ear diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the ear and mastoid process

Diseases of middle ear and mastoid

Suppurative and unspecified otitis media

Otitis media, unspecified

External Ids:

OMIM ⁵⁷ 166760

Disease Ontology ¹² DOID:10754

ICD10 ³³ H66.9 H66.90

ICD9CM ³⁵ 382.9

MeSH ⁴⁴ D010033

NCIt ⁵⁰ C34885

SNOMED-CT ⁶⁸ 65363002

MedGen ⁴² C1833692

UMLS ⁷³ C0029882 C2827407

Sources

Summaries for Otitis Media

UniProtKB/Swiss-Prot : ⁷⁵ Otitis media: An inflammation of the middle ear resulting in earache, fever, hearing disturbance, and vertigo.

MalaCards based summary : Otitis Media, also known as otitis media, susceptibility to, is related to suppurative otitis media and haemophilus influenzae. An important gene associated with Otitis Media is A2ML1 (Alpha-2-Macroglobulin Like 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cedax and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, tonsil and colon, and related phenotypes are recurrent otitis media and hematopoietic system

Disease Ontology : ¹² A otitis which involves inflammation of the middle ear.

Wikipedia : ⁷⁶ Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis... more...

Description from OMIM: 166760

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Related Diseases for Otitis Media

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 520)

#	Related Disease	Score	Top Affiliating Genes
1	suppurative otitis media	34.5	IL1B TLR2 TLR4
2	haemophilus influenzae	31.3	CXCL8 IL1B TLR2 TNF
3	tonsillitis	30.7	CD79A CXCL8 IL1B IL6 TNF
4	septic arthritis	30.7	CXCL8 TLR2 TLR4
5	rhinitis	30.7	CCL11 CXCL8 IGHE RNASE3
6	mycobacterium fortuitum	30.5	CXCL8 LACTB
7	mycobacterium abscessus	30.5	CXCL8 TLR2 TNF
8	meningitis	30.5	TNF TLR2 MBL2 LACTB IL6 IL1B
9	mycobacterium chelonae	30.5	CXCL8 TLR2
10	arthritis	30.5	CXCL8 IL10 IL1B IL6 TNF
11	ige responsiveness, atopic	30.4	IGHE IL10 RNASE3
12	allergic rhinitis	30.4	CCL11 CXCL8 IGHE IL10 RNASE3
13	paraneoplastic syndromes	30.3	IL1B IL6
14	milk allergy	30.3	CD79A IL10 RNASE3
15	osteomyelitis	30.3	CXCL8 IL10 IL1B IL6 TNF
16	conjunctivitis	30.2	CCL11 CXCL8 IL6 RNASE3
17	fasciitis	30.2	CXCL8 IL6 TNF
18	common cold	30.1	CCL11 CXCL8 MUC5AC RNASE3
19	churg-strauss syndrome	30.1	IL10 RNASE3 TNF
20	bacterial meningitis	30.0	TNF TLR2 IL6 IL1B IL10 CXCL8
21	monocytic leukemia	30.0	CXCL8 IL1B IL6 TNF
22	aseptic meningitis	30.0	CXCL8 IL10 IL1B TNF
23	sleep apnea	30.0	CXCL8 IL1B IL6 TNF
24	cytomegalovirus infection	30.0	CXCL8 IL1B IL6 TNF
25	bacterial sepsis	30.0	CXCL8 IL10 TLR4 TNF
26	lyme disease	29.9	IL1B IL6 TLR2 TNF
27	chorioamnionitis	29.9	CXCL8 IL1B IL6 TLR4 TNF
28	acquired immunodeficiency syndrome	29.9	IL10 IL1B IL6 TNF
29	middle ear disease	29.9	TNF TLR4 TLR2 MUC5B MUC5AC IL6
30	lymphadenitis	29.9	CXCL8 IL10 IL1B TLR4 TNF
31	appendicitis	29.9	CXCL8 IL10 IL1B IL6 TNF
32	bone inflammation disease	29.8	CXCL8 IL10 IL1B IL6 TNF
33	keratoconjunctivitis	29.8	CCL11 CXCL8 RNASE3 TNF
34	viral infectious disease	29.8	CXCL8 IL10 IL1B IL6 TNF
35	extrapulmonary tuberculosis	29.8	IL10 IL1B MBL2 TLR2
36	pulmonary tuberculosis	29.8	IL10 MBL2 TLR2 TNF
37	keratoconjunctivitis sicca	29.8	CD79A IL10 IL1B IL6 TNF
38	bronchitis	29.7	CCL11 CXCL8 LACTB RNASE3 TNF
39	respiratory allergy	29.7	CCL11 IGHE IL10 RNASE3
40	listeriosis	29.7	IL6 MBL2 TNF
41	peritonitis	29.7	TNF TLR2 IL6 IL1B IL10 CXCL8
42	asthma	29.7	TNF TLR4 RNASE3 MUC5AC IL6 IL1B
43	bronchiolitis	29.5	TNF TLR4 RNASE3 MUC5B IL6 IL10
44	pneumonia	29.5	TNF TLR4 TLR2 MUC5B MBL2 LACTB
45	pulmonary disease, chronic obstructive	29.4	TNF TLR2 RNASE3 MUC5AC IL6 CXCL8
46	chlamydia	29.3	TNF TLR4 TLR2 IL6 IL1B IL10
47	inflammatory bowel disease	28.9	CCL11 CXCL8 IL10 IL1B IL6 MUC2
48	acute serous otitis media	12.8
49	chronic purulent otitis media	12.8
50	non-suppurative otitis media	12.8

Comorbidity relations with Otitis Media via Phenotypic Disease Network (PDN): (show all 11)

Acute Cystitis	Bronchitis
Cholesteatoma of Middle Ear	Chronic Myocardial Ischemia
Deficiency Anemia	Heart Disease
Hypertension, Essential	Labyrinthitis
Mastoiditis	Otitis Externa
Pneumococcal Meningitis

Graphical network of the top 20 diseases related to Otitis Media:

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Symptoms & Phenotypes for Otitis Media

Symptoms via clinical synopsis from OMIM:

⁵⁷

Ears:
susceptibility to otitis media

Clinical features from OMIM:

166760

Human phenotypes related to Otitis Media:

³²

#	Description	HPO Frequency	HPO Source Accession
1	recurrent otitis media ³²		HP:0000403

MGI Mouse Phenotypes related to Otitis Media:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10	CCL11 CD79A IL10 IL1B IL6 MBL2
2	homeostasis/metabolism	MP:0005376	9.93	CD79A FBXO11 IL10 IL1B IL6 MBL2
3	digestive/alimentary	MP:0005381	9.92	FBXO11 IL10 IL6 MUC2 MUC5AC TLR2
4	immune system	MP:0005387	9.77	CCL11 CD79A FBXO11 IL10 IL1B IL6
5	neoplasm	MP:0002006	9.23	CD79A IL10 IL1B IL6 MUC2 TLR2

Sources

Drugs & Therapeutics for Otitis Media

FDA approved drugs:

#	Drug Name	Active Ingredient(s) ¹⁸	Company	Approval Date
1	Cedax ¹⁸	CEFTIBUTEN DIHYDRATE	Schering-Plough	December 1995
FDA Label: Cedax Disease/s that Drug Treats:chronic bronchitis, infection of the middle ear, pharyngitis/tonsillitis Indications and Usage: ¹⁸ CEDAX (ceftibuten) is indicated for the treatment of individuals with mild-to-moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below (see DOSAGE AND ADMINISTRATION and CLINICAL STUDIES sections). Acute Bacterial Exacerbations of Chronic Bronchitis due to Haemophilus influenzae (including Î²-lactamase-producing strains), Moraxella catarrhalis (including Î²-lactamaseproducing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only). NOTE: In acute bacterial exacerbations of chronic bronchitis clinical trials where Moraxella catarrhalis was isolated from infected sputum at baseline, ceftibuten clinical efficacy was 22% less than control. Acute Bacterial Otitis Media due to Haemophilus influenzae (including Î²-lactamase-producing strains), Moraxella catarrhalis (including Î²-lactamase-producing strains), or Streptococcus pyogenes. NOTE: Although ceftibuten used empirically was equivalent to comparators in the treatment of clinically and/or microbiologically documented acute otitis media, the efficacy against Streptococcus pneumoniae was 23% less than control. Therefore, ceftibuten should be given empirically only when adequate antimicrobial coverage against Streptococcus pneumoniae has been previously administered. Pharyngitis and Tonsillitis due to Streptococcus pyogenes. NOTE: Only penicillin by the intramuscular route of administration has been shown to be effective in the prophylaxis of rheumatic fever. Ceftibuten is generally effective in the eradication of Streptococcus pyogenes from the oropharynx; however, data establishing the efficacy of the CEDAX product for the prophylaxis of subsequent rheumatic fever are not available. DrugBank Targets: ¹⁶ Peptidoglycan synthase FtsI\|Penicillin-binding protein 1A\|Penicillin-binding protein 1B\|Penicillin-binding protein 2 Mechanism of Action: ¹⁸ Target: - Action: - FDA: -

Drugs for Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 269)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Amoxicillin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

26787-78-0

33613

Halofantrine

Approved

Phase 4

69756-53-2

37393

Montelukast

Approved

Phase 4,Phase 3,Not Applicable

158966-92-8

5281040

Strawberry

Approved

Phase 4

Lansoprazole

Approved, Investigational

Phase 4,Not Applicable

103577-45-3

3883

Dexlansoprazole

Approved, Investigational

Phase 4,Not Applicable

103577-45-3, 138530-94-6

9578005

Azithromycin

Approved

Phase 4,Phase 3,Phase 2

83905-01-5

55185 447043

Cefdinir

Approved

Phase 4,Phase 2,Phase 3

91832-40-5

6915944

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3

437-38-7

3345

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Oseltamivir

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

204255-11-8, 196618-13-0

65028

Ibuprofen

Approved

Phase 4,Not Applicable

15687-27-1

3672

Acetaminophen

Approved

Phase 4,Phase 2,Not Applicable

103-90-2

1983

Histamine

Approved, Investigational

Phase 4,Phase 3,Not Applicable

51-45-6, 75614-87-8

774

Fluticasone

Approved, Experimental

Phase 4

90566-53-3

62924

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2

1177-87-3

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

85721-33-1

2764

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2

50-02-2

5743

Levofloxacin

Approved, Investigational

Phase 4,Phase 3

100986-85-4

149096

Ofloxacin

Approved

Phase 4,Phase 3

82419-36-1

4583

Ketorolac

Approved

Phase 4

66635-83-4, 74103-06-3

3826

Phenylephrine

Approved

Phase 4,Not Applicable

59-42-7

6041

Oxymetazoline

Approved, Investigational

Phase 4,Not Applicable

1491-59-4

4636

Ephedrine

Approved

Phase 4,Not Applicable

299-42-3

9294

Pseudoephedrine

Approved

Phase 4,Not Applicable

90-82-4

7028

Cetirizine

Approved

Phase 4

83881-51-0

2678

Methylprednisolone

Approved, Vet_approved

Phase 4,Early Phase 1

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4,Early Phase 1

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4,Early Phase 1

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Early Phase 1

302-25-0

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

BCG vaccine

Investigational

Phase 4

Andrographolide

Investigational

Phase 4

5508-58-7

Prednisolone hemisuccinate

Experimental

Phase 4,Early Phase 1

2920-86-7

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Amoxicillin-Potassium Clavulanate Combination

Phase 4,Phase 3,Phase 2

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Clavulanic Acids

Phase 4,Phase 3,Phase 2,Not Applicable

beta-Lactamase Inhibitors

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1

Anti-Asthmatic Agents

Phase 4,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1

Leukotriene Antagonists

Phase 4,Not Applicable

Respiratory System Agents

Phase 4,Not Applicable

Hormones

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1

Heptavalent Pneumococcal Conjugate Vaccine

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Vaccines

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Anesthetics, General

Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 322)

#	Name	Status	NCT ID	Phase	Drugs
1	Amoxicillin Clavulanate in Treatment of Acute Otitis Media	Unknown status	NCT00299455	Phase 4	amoxicillin-clavulanate;Placebo
2	The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children	Unknown status	NCT00393159	Phase 4
3	Acute Otitis Media (AOM) Therapy Trial in Young Children	Completed	NCT00377260	Phase 4	amoxicillin-clavulanate;Placebo
4	A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children	Completed	NCT00189462	Phase 4	Montelukast
5	Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children	Completed	NCT00539149	Phase 4	Amoxycillin;Placebo equivalent to amoxycillin
6	Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children	Completed	NCT01082029	Phase 4	Lansoprazole;Placebo
7	A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media	Completed	NCT00645112	Phase 4	cefdinir (Omnicef);azithromycin
8	A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media	Completed	NCT00644943	Phase 4	cefdinir (Omnicef);amoxicillin
9	Pneumococcal Vaccines Early and in Combination	Completed	NCT01174849	Phase 4	Synflorix;Prevenar13;COMBO
10	Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy	Completed	NCT01244126	Phase 4	Intranasal fentanyl;morphine IM;IV morphine
11	Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)	Completed	NCT00419380	Phase 4	dornase alfa (Pulmozyme®)
12	Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age	Completed	NCT00593502	Phase 4	oseltamivir;placebo
13	Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children.	Completed	NCT01694108	Phase 4
14	Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics)	Completed	NCT01800747	Phase 4
15	DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect	Completed	NCT00424905	Phase 4	Bacillus clausii
16	Hutterite Influenza Prevention Study	Completed	NCT00877396	Phase 4
17	A Study to Evaluate the Safety of HIN1 Monovalent Vaccine (MEDI3414) in Children 2 to 17 Years of Age	Completed	NCT00946101	Phase 4
18	A Study to Evaluate the Safety of H1N1 Monovalent Vaccine (MEDI3414) in Healthy Adults	Completed	NCT00945893	Phase 4
19	Live Versus Inactivated Influenza Vaccine Study in Hutterite Children	Completed	NCT01653015	Phase 4
20	Clinical Trial of Clinical Efficiency and Safety of Ergoferon in Treatment of Influenza	Completed	NCT01804946	Phase 4	Ergoferon;Oseltamivir
21	Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children	Recruiting	NCT02935374	Phase 4	Amoxicillin;Amoxicillin-Potassium Clavulanate;Macrolide
22	Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children	Recruiting	NCT02653742	Phase 4	Ketorolac;Fentanyl
23	Group A Pharyngitis in Children: The GASPARD Study	Recruiting	NCT03264911	Phase 4	Amoxicillin or Placebo
24	A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis	Recruiting	NCT03132610	Phase 4	andrographolide sulfonate;andrographolide sulfonate simulation
25	Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis	Recruiting	NCT03134443	Phase 4	Andrographolide sulfonate;Andrographolide sulfonate simulation
26	The Benefit and Harm of Fever Suppression by Antipyretics in Influenza	Recruiting	NCT01891084	Phase 4	Paracetamol;Placebo;Backup NSAID ibuprofen
27	Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life	Active, not recruiting	NCT01735084	Phase 4
28	Efficacy and Cost Analysis of Steroid Spray in Treatment of Otitis Media With Effusion	Not yet recruiting	NCT03590912	Phase 4	Fluticasone Nasal;Anti Histamine plus Nasal decongestents;Steroid Drug
29	N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media	Not yet recruiting	NCT00956748	Phase 4	Ciprodex;Ciprodex and 2% NAC
30	Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present	Not yet recruiting	NCT03655665	Phase 4	Ofloxacin otic solution
31	A Study of Tamiflu (Oseltamivir) for Treatment of Influenza With a Focus on (H1N1) 2009 Flu Strain	Terminated	NCT01032837	Phase 4	Oseltamivir;Oseltamivir;Placebo
32	Otiprio Versus Ciprodex Tympanostomy Tube Outcomes	Withdrawn	NCT03347461	Phase 4	Otiprio;Ciprodex
33	A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media	Unknown status	NCT00271778	Phase 3
34	PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease	Unknown status	NCT00310349	Phase 3
35	Preventing Early Childhood Caries in Indigenous Children: the Baby Teeth Talk Study	Unknown status	NCT02151916	Phase 3
36	Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children	Unknown status	NCT01619462	Phase 3
37	Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children	Completed	NCT01044030	Phase 3	Xylitol syrup;Placebo
38	Improving Otitis Media Care With Clinical Decision Support	Completed	NCT00581711	Phase 3
39	Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media	Completed	NCT02858388	Phase 3
40	Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence	Completed	NCT02345447	Phase 3	Herbal-based medication;Placebo
41	Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes	Completed	NCT02600559	Phase 3	OTO-201 (ciprofloxacin)
42	Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children	Completed	NCT00781521	Phase 3	ofloxacin otic solution 0.3%
43	A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes	Completed	NCT00578474	Phase 3	Moxidex otic solution;Ofloxacin otic solution
44	Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children	Completed	NCT02541760	Phase 3	Monteleukast;Mometasone
45	Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media	Completed	NCT00638534	Phase 3	Telithromycin (HMR3647)
46	Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media	Completed	NCT02044341	Phase 3	AR01;Glycerin ear drops
47	Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes	Completed	NCT00378417	Phase 3
48	Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT)	Completed	NCT02432105	Phase 3	EXE844 Sterile Otic Suspension, 0.3%
49	Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2	Completed	NCT02436304	Phase 3	EXE844 Sterile Otic Suspension, 0.3%
50	Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes	Completed	NCT00579189	Phase 3	Moxidex otic solution;Moxifloxacin otic solution

Search NIH Clinical Center for Otitis Media

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

acetyl sulfisoxazole

antipyrine

benzocaine

benzocaine pwdr

ceftibuten dihydrate

sulfisoxazole

sulfisoxazole diolamine

Cochrane evidence based reviews: otitis media

Sources

Genetic Tests for Otitis Media

Genetic tests related to Otitis Media:

#	Genetic test	Affiliating Genes
1	Otitis Media ²⁹

Sources

Anatomical Context for Otitis Media

MalaCards organs/tissues related to Otitis Media:

⁴¹

Bone, Tonsil, Colon, Testes, Neutrophil, Brain, Lung

Sources

Publications for Otitis Media

Articles related to Otitis Media:

(show top 50) (show all 2528)

#	Title	Authors	Year
1	A mixed-methods study of the management of hearing loss associated with otitis media with effusion in children with Down syndrome. ( 30222906 )	Hall A...Schilder AGM	2019
2	The use of bone conduction hearing implants in paediatric chronic otitis media: An audit of outcomes of 32 devices in 22 patients. ( 30270554 )	Dawe N...Johnson IJM	2019
3	Diagnostic Accuracy, Prescription Behavior, and Watchful Waiting Efficacy for Pediatric Acute Otitis Media. ( 30311779 )	Brinker DL...Hackman N	2019
4	Studying PCV impact on clinical presentation of otitis media helps to understand its pathogenesis. ( 30497832 )	Ben-Shimol S...Dagan R	2019
5	The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )	Delrue S...Somers T	2019
6	Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis. ( 30540698 )	Berling Holm K...von Unge M	2019
7	Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress. ( 30551453 )	Guo H...Xu LJ	2019
8	Probiotics in the treatment of otitis media. The past, the present and the future. ( 30554684 )	Coleman A...Cervin A	2019
9	Characteristics of children with refractory acute otitis media treated at the pediatric emergency department. ( 30554692 )	Pitaro J...Lapointe A	2019
10	Clinical role of vitamin D in prognosis of otitis media with effusion. ( 29447793 )	Akcan F.A....A9nlA1 A.^.	2018
11	Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )	Singer A.E.A....Mohamed A.R.	2018
12	To Evaluate and Compare the Result of Ossiculoplasty Using Different Types of Graft Materials and Prosthesis in Cases of Ossicular Discontinuity in Chronic Suppurative Otitis Media Cases. ( 29456937 )	Kumar S....Gakhar S.	2018
13	In vivo detection of nanometer-scale structural changes of the human tympanic membrane in otitis media. ( 29884809 )	Dsouza R....Boppart S.A.	2018
14	Otitis Media with Effusion (OME) in Urban Pediatric Population in a Tertiary Care Centre: A Clinical Study. ( 29977853 )	Bandyopadhyay T....Raman E.V.	2018
15	A pilot study to investigate the therapeutic effect of Valsalva maneuver on otitis media with effusion in adults. ( 29914826 )	Han J.J....Park S.N.	2018
16	Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media. ( 29073815 )	Deng R....Chen B.	2018
17	Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. ( 29322750 )	DI Pierro F....Giannattasio A.	2018
18	The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. ( 29951099 )	Darmawan A.B....Surono A.	2018
19	Air Pollution and Otitis Media in Children: A Systematic Review of Literature. ( 29401661 )	Bowatte G....Dharmage S.C.	2018
20	Ambulatory Visits for Otitis Media before and after the Introduction of Pneumococcal Conjugate Vaccination. ( 29958675 )	Kawai K....Kenna M.A.	2018
21	The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis. ( 29885746 )	Okada M....Hato N.	2018
22	No evidence of cholesteatoma in untreated otitis media with effusion in children with primary ciliary dyskinesia. ( 29447810 )	Ghedia R....Harcourt J.	2018
23	Response to comment: Eustachian tube diameter: Is it associated with chronic otitis media development? ( 29426733 )	Paltura C....KA1lekAsi M.	2018
24	Group A streptococcus acute otitis media progressing to neuroinvasive disease in adults. ( 29942780 )	Patel K.M....Nau G.J.	2018
25	Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )	Adriztina I....Lubis Y.M.	2018
26	Pneumococcal phenotype and interaction with nontypeable<i>Haemophilus influenzae</i>as determinants of otitis media progression. ( 29378791 )	Lewnard J.A....Dagan R.	2018
27	The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. ( 29888693 )	Ersoy B....Sipal S.	2018
28	The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1I^, IL-1RA Is Favorably Associated With Chronic Otitis Media. ( 29433161 )	A1ivkoviA8 M....StankoviA8 A.	2018
29	International consensus (ICON) on management of otitis media with effusion in children. ( 29398506 )	Simon F....Teissier N.	2018
30	Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. ( 29671212 )	Punia R.S....Chander J.	2018
31	Risk of childhood otitis media with focus on potentially modifiable factors: A Danish follow-up cohort study. ( 29447878 )	KA...e P.	2018
32	Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control. ( 29415741 )	Thorrington D....van Hoek A.J.	2018
33	Development of an ear cap in chronic suppurative otitis media using additive manufacturing and TRIZ. ( 29916767 )	Mawale M.B....Dahake S.W.	2018
34	Air pollution influences the incidence of otitis media in children: A national population-based study. ( 29953484 )	Park M....Park M.K.	2018
35	Anatomical anomalies of the Eustachian tube and chronic otitis media. ( 29395282 )	Lou Z....Lou Z.	2018
36	Optimal control of asthma improved eosinophilic otitis media. ( 29423372 )	Seo Y....Tagaya E.	2018
37	Tympanostomy tubes for serous otitis media and risk of recurrences. ( 29447881 )	Klopp-Dutote N....Page C.	2018
38	The Impact of Clinical Pathways on Antibiotic Prescribing for Acute Otitis Media and Pharyngitis in the Emergency Department. ( 29561517 )	Dona D....Giaquinto C.	2018
39	Successful treatment of eosinophilic otitis media associated with severe bronchial asthma with an anti-IL-5 monoclonal antibody, mepolizumab. ( 29909018 )	Suzaki I....Kobayashi H.	2018
40	Meningitis as a consequence of otitis media in a child referred from the newborn hearing screening programme: A missed opportunity. ( 29427298 )	Matarazzo L....Barbi E.	2018
41	Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model. ( 29449589 )	Mulay A....Bingle C.D.	2018
42	Aerobic bacteria associated with chronic suppurative otitis media in Angola. ( 29720274 )		2018
43	Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats. ( 29947185 )		2018
44	Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )		2018
45	Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma. ( 29681564 )		2018
46	Prevalence of otitis media and risk-factors for sensorineural hearing loss among infants attending Child Welfare Clinics in the Solomon Islands. ( 29958609 )		2018
47	Genetic counseling in an indigenous Filipino community with a high prevalence of A2ML1-related otitis media. ( 29949068 )		2018
48	Neurological Complications of Acute and Chronic Otitis Media. ( 29445883 )		2018
49	Intracochlear Pressures in Simulated Otitis Media With Effusion: A Temporal Bone Study. ( 29912830 )		2018
50	Innovative Use of Tympanometry and Scintigraphy in Preoperative Assessment of the Patients with Chronic Otitis Media. ( 29977845 )		2018

Sources

Genes for Otitis Media

Genes related to Otitis Media (1 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	A2ML1	Alpha-2-Macroglobulin Like 1	Protein Coding	619.02	Molecular basis known ⁵⁷ Susceptibility factor ⁵⁷ Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Variants (show sections)	27484237
2	FBXO11	F-Box Protein 11	Protein Coding	34.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
3	TLR2	Toll Like Receptor 2	Protein Coding	28.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16884531 11867630 19434266
4	RNASE3	Ribonuclease A Family Member 3	Protein Coding	27.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16883790 8516010 9230321 (more) 8643262 10669113 8822719
5	MBL2	Mannose Binding Lectin 2	Protein Coding	26.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8403525 15742161 16750996 (more) 15882439 11077335 16893079 10897301
6	IL1B	Interleukin 1 Beta	Protein Coding	24.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	24.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TNF	Tumor Necrosis Factor	Protein Coding	24.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	23.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	TLR4	Toll Like Receptor 4	Protein Coding	23.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL6	Interleukin 6	Protein Coding	23.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CD79A	CD79a Molecule	Protein Coding	23.12	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15882439 1625088 18008233 (more) 20198985 15563731 2206498
13	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	22.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12737295
14	SHOX	Short Stature Homeobox	Protein Coding	22.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	10575123 17456178 10823798
15	IL10	Interleukin 10	Protein Coding	22.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	22.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	LACTB	Lactamase Beta	Protein Coding	22.01	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19718741 16540890 2060691 (more) 2375816 9727652
18	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	19.96	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19718741 18957283 16540890
19	OMS	Otitis Media, Susceptibility To	Genetic Locus	17.65	GeneCards inferred via : Publications Gene name (show sections)
20	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	12.76	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16620332 10471862 16883790 (more) 1625088
21	ALB	Albumin	Protein Coding	12.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	IL4	Interleukin 4	Protein Coding	12.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Otitis Media

ClinVar genetic disease variations for Otitis Media:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	A2ML1	NM_144670.5(A2ML1): c.2478_2485dupGGCTAAAT (p.Ser829Trpfs)	duplication	Pathogenic,risk factor	rs863224951	GRCh37	Chromosome 12, 9004820: 9004827
2	A2ML1	NM_144670.5(A2ML1): c.2478_2485dupGGCTAAAT (p.Ser829Trpfs)	duplication	Pathogenic,risk factor	rs863224951	GRCh38	Chromosome 12, 8852224: 8852231

Sources

Expression for Otitis Media

Genes differentially expressed in tissues of Otitis Media patients vs. healthy controls: ³⁵

#	Gene	Description	Tissue	Up/Dn	Fold Change (log2)	P value
1	PNLIPRP3	pancreatic lipase-related protein 3	Blood	-	6.47	0.003
2	FAM20A	family with sequence similarity 20, member A	Blood	+	3.09	0.015

Search GEO for disease gene expression data for Otitis Media.

Sources

Pathways for Otitis Media

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.02	CCL11 CD79A CXCL8 IGHE IL10 IL1B
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.44	CCL11 CXCL8 IL10 IL1B IL6 TLR2
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.37	CCL11 CXCL8 IGHE IL10 IL1B IL6
4	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	13.07	CXCL8 IL1B IL6 TLR2 TLR4 TNF
5	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	13.05	CXCL8 IL10 IL1B IL6 MBL2 TLR2
6	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.92	CCL11 CXCL8 IL10 IL1B IL6 RNASE3
7	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.83	CXCL8 IL1B IL6 TLR2 TLR4 TNF
8	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ³⁷ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁷ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁵	12.78	CXCL8 IL1B IL6 TLR4 TNF
9	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.72	IL1B IL6 TLR2 TLR4 TNF
10	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.64	IL10 IL1B IL6 TLR2 TLR4 TNF
11	NF-kappaB Signaling ⁴	12.6	CD79A IL10 IL1B TLR2 TNF
12	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.43	IL1B MUC2 MUC5AC MUC5B
13	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.43	IL10 IL1B IL6 TNF
14	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.36	CXCL8 IL1B IL6 TLR4 TNF
15	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.32	CXCL8 IL6 TLR2 TLR4 TNF
16	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.31	IL10 IL1B TLR2 TLR4 TNF
17	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.3	CXCL8 IL10 IL1B IL6 TNF
18	Tuberculosis ³⁷	12.29	IL10 IL1B IL6 TLR2 TLR4 TNF
19	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.26	CCL11 CXCL8 IL1B IL6 MUC5AC MUC5B
20	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.24	IL10 IL1B IL6 TNF
21	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.23	CXCL8 IL10 IL1B IL6 TNF
22	Colorectal Cancer Metastasis ⁶⁴	12.22	IL6 TLR2 TLR4 TNF
23	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.22	CCL11 CXCL8 IL1B IL6 TLR2 TLR4
24	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	12.12	IL10 IL1B IL6 TLR2 TLR4 TNF
25	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.11	CCL11 CXCL8 IL10 IL1B IL6
26	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	12.1	IL1B IL6 TLR2 TLR4 TNF
27	Spinal Cord Injury ¹	12.08	CXCL8 IL1B IL6 TLR4 TNF
28	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.04	CD79A IL10 IL6 TNF
29	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12	CXCL8 IL1B IL6 MUC2 MUC5AC MUC5B
30	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.96	CXCL8 IL1B IL6 TNF
31	NF-kappa B signaling pathway ³⁷	11.94	CXCL8 IL1B TLR4 TNF
32	Rheumatoid arthritis ³⁷	11.91	CXCL8 IL1B IL6 TLR2 TLR4 TNF
33	Salmonella infection (KEGG) ³⁷	11.89	CXCL8 IL1B IL6 TLR4
34	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.87	CXCL8 IL6 TLR4
35	Interleukin-4 and 13 signaling ⁶⁶	11.86	CCL11 CXCL8 IGHE IL10 IL1B IL6
36	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.82	IL10 IL1B IL6 TNF
37	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.79	IL10 IL1B TNF
38	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.79	CCL11 IL10 IL1B IL6 TNF
39	Pertussis ³⁷	11.79	CXCL8 IL10 IL1B IL6 TLR4 TNF
40	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.72	CXCL8 IL1B IL6 TNF
41	IL4-mediated signaling events ¹	11.68	CCL11 IGHE IL10
42	Lung fibrosis ¹	11.68	CCL11 CXCL8 IL1B IL6 MUC5B TNF
43	Interleukin-10 signaling ⁶⁶	11.6	CXCL8 IL10 IL1B IL6 TNF
44	MSP-RON Signaling ⁶⁴	11.59	IL1B TLR2 TLR4 TNF
45	Legionellosis ³⁷	11.59	CXCL8 IL1B IL6 TLR2 TLR4 TNF
46	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.54	CCL11 CXCL8 IL6
47	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.52	IL1B IL6 TNF
48	IL-10 Pathway ⁶⁴	11.44	IL10 IL1B IL6 TLR4 TNF
49	African trypanosomiasis ³⁷	11.43	IL10 IL1B IL6 TNF
50	Development and heterogeneity of the ILC family ¹	11.36	IL1B IL6 TNF

Sources

GO Terms for Otitis Media

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	A2ML1 CCL11 CXCL8 IGHE IL10 IL1B
2	extracellular space	GO:0005615	9.36	A2ML1 CCL11 CXCL8 IL10 IL1B IL6

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to bacterium	GO:0042742	9.97	IGHE IL10 MBL2 RNASE3 TLR4 TNF
2	response to lipopolysaccharide	GO:0032496	9.96	IL10 IL1B TLR2 TLR4
3	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.92	IL1B IL6 TLR2 TLR4 TNF
4	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.91	IL10 IL1B IL6 TNF
5	defense response to Gram-negative bacterium	GO:0050829	9.89	IL6 RNASE3 TLR4
6	neutrophil chemotaxis	GO:0030593	9.88	CCL11 CXCL8 IL1B
7	positive regulation of JNK cascade	GO:0046330	9.88	IL1B TLR4 TNF
8	positive regulation of inflammatory response	GO:0050729	9.87	TLR2 TLR4 TNF
9	response to glucocorticoid	GO:0051384	9.87	IL10 IL1B IL6 TNF
10	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.85	MUC2 MUC5AC MUC5B
11	cellular response to lipopolysaccharide	GO:0071222	9.85	CXCL8 IL10 IL1B IL6 TLR4 TNF
12	O-glycan processing	GO:0016266	9.84	MUC2 MUC5AC MUC5B
13	defense response to Gram-positive bacterium	GO:0050830	9.83	IL6 MBL2 RNASE3 TLR2 TNF
14	positive regulation of interferon-gamma production	GO:0032729	9.82	IL1B TLR4 TNF
15	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.82	IL1B TLR4 TNF
16	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.81	IL1B TLR2 TLR4 TNF
17	positive regulation of phagocytosis	GO:0050766	9.8	IL1B MBL2 TNF
18	cytokine-mediated signaling pathway	GO:0019221	9.8	CCL11 CXCL8 IGHE IL10 IL1B IL6
19	negative regulation of interleukin-6 production	GO:0032715	9.78	IL10 TLR4 TNF
20	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.78	IL1B TLR2 TLR4 TNF
21	negative regulation of neurogenesis	GO:0050768	9.77	IL1B IL6 TNF
22	positive regulation of glial cell proliferation	GO:0060252	9.75	IL1B IL6 TNF
23	negative regulation of growth of symbiont in host	GO:0044130	9.73	IL10 MBL2 TNF
24	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.72	IL10 IL1B TNF
25	regulation of cytokine secretion	GO:0050707	9.71	TLR2 TLR4
26	I-kappaB phosphorylation	GO:0007252	9.71	TLR2 TLR4
27	response to molecule of bacterial origin	GO:0002237	9.71	CXCL8 IL10 TLR2
28	positive regulation of interleukin-8 production	GO:0032757	9.71	IL1B TLR2 TLR4 TNF
29	cellular response to lipoteichoic acid	GO:0071223	9.7	TLR2 TLR4
30	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.69	TLR4 TNF
31	negative regulation of lipid storage	GO:0010888	9.69	IL6 TNF
32	endothelial cell apoptotic process	GO:0072577	9.69	IL10 TNF
33	positive regulation of chemokine biosynthetic process	GO:0045080	9.68	IL1B TNF
34	positive regulation of MHC class II biosynthetic process	GO:0045348	9.67	IL10 TLR4
35	regulation of establishment of endothelial barrier	GO:1903140	9.67	IL1B TNF
36	negative regulation of cytokine secretion involved in immune response	GO:0002740	9.66	IL10 TNF
37	positive regulation of fever generation	GO:0031622	9.65	IL1B TNF
38	chronic inflammatory response to antigenic stimulus	GO:0002439	9.64	IL1B TNF
39	sequestering of triglyceride	GO:0030730	9.63	IL1B TNF
40	positive regulation of neuroinflammatory response	GO:0150078	9.63	IL1B IL6 TNF
41	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.62	IL1B TNF
42	receptor biosynthetic process	GO:0032800	9.62	IL10 TNF
43	positive regulation of chemokine production	GO:0032722	9.62	IL6 TLR2 TLR4 TNF
44	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.6	TLR2 TLR4
45	inflammatory response	GO:0006954	9.56	CCL11 CXCL8 IL10 IL1B IL6 TLR2
46	positive regulation of interleukin-6 production	GO:0032755	9.55	IL1B IL6 TLR2 TLR4 TNF
47	immune response	GO:0006955	9.28	CCL11 CXCL8 IGHE IL10 IL1B IL6
48	positive regulation of transcription by RNA polymerase II	GO:0045944	10.22	IL10 IL1B IL6 SHOX TLR2 TLR4
49	innate immune response	GO:0045087	10.11	IGHE MBL2 RNASE3 TLR2 TLR4
50	negative regulation of cell proliferation	GO:0008285	10.08	CXCL8 IL10 IL1B IL6 TLR2

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide receptor activity	GO:0001875	9.16	TLR2 TLR4
2	lipopolysaccharide binding	GO:0001530	9.13	RNASE3 TLR2 TLR4
3	cytokine activity	GO:0005125	9.1	CCL11 CXCL8 IL10 IL1B IL6 TNF

Sources

Sources for Otitis Media

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Otitis Media (OM)

Aliases & Classifications for Otitis Media

MalaCards integrated aliases for Otitis Media:

Characteristics:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Otitis Media

Related Diseases for Otitis Media

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Otitis Media via Phenotypic Disease Network (PDN): (show all 11)

Graphical network of the top 20 diseases related to Otitis Media:

Symptoms & Phenotypes for Otitis Media

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

Human phenotypes related to Otitis Media:

MGI Mouse Phenotypes related to Otitis Media:

Drugs & Therapeutics for Otitis Media

FDA approved drugs:

Drugs for Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: otitis media

Genetic Tests for Otitis Media

Genetic tests related to Otitis Media:

Anatomical Context for Otitis Media

MalaCards organs/tissues related to Otitis Media:

Publications for Otitis Media

Articles related to Otitis Media:

Genes for Otitis Media

Genes related to Otitis Media (1 elite genes):

Variations for Otitis Media

ClinVar genetic disease variations for Otitis Media:

Expression for Otitis Media

Pathways for Otitis Media

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

GO Terms for Otitis Media

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

Sources for Otitis Media

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :