OM
MCID: OTT002
MIFTS: 68

Otitis Media (OM)

Categories: Ear diseases, Genetic diseases

Aliases & Classifications for Otitis Media

MalaCards integrated aliases for Otitis Media:

Name: Otitis Media 58 12 76 30 56 45 15 17 74 3
Otitis Media, Susceptibility to 58 13 6
Otitis Media, Chronic/recurrent 58 76
Come/rom 58 76
Oms 58 76
Infectious Otitis Media 74
Om 76

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
otitis media:
Inheritance polygenic inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:10754
OMIM 58 166760
ICD9CM 36 382.9
MeSH 45 D010033
NCIt 51 C34885
SNOMED-CT 69 65363002
ICD10 34 H66.9 H66.90
MedGen 43 C1833692

Summaries for Otitis Media

UniProtKB/Swiss-Prot : 76 Otitis media: An inflammation of the middle ear resulting in earache, fever, hearing disturbance, and vertigo.

MalaCards based summary : Otitis Media, also known as otitis media, susceptibility to, is related to suppurative otitis media and haemophilus influenzae. An important gene associated with Otitis Media is A2ML1 (Alpha-2-Macroglobulin Like 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cedax and Clavulanate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and tonsil, and related phenotypes are recurrent otitis media and homeostasis/metabolism

Disease Ontology : 12 A otitis which involves inflammation of the middle ear.

Wikipedia : 77 Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis... more...

Description from OMIM: 166760

Related Diseases for Otitis Media

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)
# Related Disease Score Top Affiliating Genes
1 suppurative otitis media 34.6 IL1B TLR2 TLR4
2 haemophilus influenzae 31.7 CXCL8 IL1B TLR2 TNF
3 septic arthritis 30.9 CXCL8 TLR2 TLR4
4 mycobacterium fortuitum 30.8 CXCL8 LACTB
5 ige responsiveness, atopic 30.8 IGHE IL10 RNASE3
6 rhinitis 30.8 CCL11 CXCL8 IGHE RNASE3
7 tonsillitis 30.7 CD79A CXCL8 IL1B IL6 TNF
8 mycobacterium chelonae 30.7 CXCL8 TLR2
9 spinal cord injury 30.6 CXCL8 IL6 TNF
10 arthritis 30.5 CXCL8 IL10 IL1B IL6 TNF
11 food allergy 30.4 ALB IL10 RNASE3
12 conjunctivitis 30.4 CCL11 CXCL8 IL6 RNASE3
13 pericarditis 30.4 IL1B IL6 TNF
14 duodenal ulcer 30.4 CXCL8 IL1B TNF
15 milk allergy 30.4 CD79A IL10 RNASE3
16 fasciitis 30.4 CXCL8 IL6 TNF
17 allergic rhinitis 30.4 CCL11 CXCL8 IGHE IL10 RNASE3
18 osteomyelitis 30.3 CXCL8 IL10 IL1B IL6 TNF
19 hematopoietic stem cell transplantation 30.3 IL10 IL6 TNF
20 tuberculous meningitis 30.3 CXCL8 TLR2 TNF
21 sleep apnea 30.3 CXCL8 IL1B IL6 TNF
22 churg-strauss syndrome 30.3 IL10 RNASE3 TNF
23 listeriosis 30.3 IL6 MBL2 TNF
24 meningoencephalitis 30.2 ALB CD79A IL6
25 extrapulmonary tuberculosis 30.2 IL10 IL1B TLR2
26 mycobacterium abscessus 30.1 CXCL8 TLR2 TNF
27 aseptic meningitis 30.1 CXCL8 IL10 IL1B TNF
28 cytomegalovirus infection 30.0 CXCL8 IL1B IL6 TNF
29 bacterial sepsis 30.0 CXCL8 IL10 TLR4 TNF
30 acute cystitis 30.0 ALB CXCL8 IL6
31 monocytic leukemia 30.0 CXCL8 IL1B IL6 TNF
32 lyme disease 30.0 IL1B IL6 TLR2 TNF
33 chorioamnionitis 30.0 CXCL8 IL1B IL6 TLR4 TNF
34 lymphadenitis 29.9 CXCL8 IL10 IL1B TLR4 TNF
35 rheumatic fever 29.9 IL10 IL6 MBL2 TNF
36 bone inflammation disease 29.9 CXCL8 IL10 IL1B IL6 TNF
37 keratoconjunctivitis 29.9 CCL11 CXCL8 RNASE3 TNF
38 meningitis 29.8 TNF TLR2 MBL2 LACTB IL6 IL1B
39 chlamydia 29.8 TNF TLR4 TLR2 IL6 IL1B IL10
40 respiratory allergy 29.7 CCL11 IGHE IL10 RNASE3
41 bacterial meningitis 29.7 TNF TLR2 IL6 IL1B IL10 CXCL8
42 common cold 29.6 RNASE3 MUC5AC CXCL8 CCL11 ALB
43 pulmonary tuberculosis 29.6 IL10 MBL2 TLR2 TNF
44 asthma 29.6 CCL11 CXCL8 IGHE IL10 IL1B IL6
45 middle ear disease 29.6 TNF TLR4 TLR2 MUC5B MUC5AC IL6
46 acquired immunodeficiency syndrome 29.5 ALB IL10 IL1B IL6 TNF
47 inflammatory bowel disease 29.4 IL1B IL10 CXCL8 TNF TLR4 TLR2
48 bronchitis 29.4 TNF RNASE3 LACTB CXCL8 CCL11 ALB
49 appendicitis 29.4 TNF IL6 IL1B IL10 CXCL8 ALB
50 pulmonary disease, chronic obstructive 29.4 TNF TLR2 RNASE3 MUC5AC IL6 CXCL8

Comorbidity relations with Otitis Media via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Bronchitis
Cholesteatoma of Middle Ear Chronic Myocardial Ischemia
Deficiency Anemia Heart Disease
Hypertension, Essential Labyrinthitis
Mastoiditis Otitis Externa
Pneumococcal Meningitis

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to Otitis Media

Symptoms & Phenotypes for Otitis Media

Human phenotypes related to Otitis Media:

33
# Description HPO Frequency HPO Source Accession
1 recurrent otitis media 33 HP:0000403

Symptoms via clinical synopsis from OMIM:

58
Head And Neck Ears:
otitis media

Clinical features from OMIM:

166760

MGI Mouse Phenotypes related to Otitis Media:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ALB CD79A FBXO11 IL10 IL1B IL6
2 immune system MP:0005387 9.93 CCL11 CD79A FBXO11 IL10 IL1B IL6
3 digestive/alimentary MP:0005381 9.92 ALB FBXO11 IL10 IL6 MUC5AC TLR2
4 liver/biliary system MP:0005370 9.5 ALB CD79A IL10 IL6 TLR2 TLR4
5 neoplasm MP:0002006 9.23 ALB CD79A IL10 IL1B IL6 TLR2

Drugs & Therapeutics for Otitis Media

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Cedax 19 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 274)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
3
Halofantrine Approved Phase 4 69756-53-2 37393
4
Montelukast Approved Phase 4,Phase 3,Not Applicable 158966-92-8 5281040
5
carbamide peroxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-43-6
6 Strawberry Approved Phase 4
7
Lansoprazole Approved, Investigational Phase 4,Not Applicable 103577-45-3 3883
8
Dexlansoprazole Approved, Investigational Phase 4,Not Applicable 138530-94-6, 103577-45-3 9578005
9
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
10
Cefdinir Approved Phase 4,Phase 2,Phase 3 91832-40-5 6915944
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 437-38-7 3345
12
Morphine Approved, Investigational Phase 4 57-27-2 5288826
13
Oseltamivir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 204255-11-8, 196618-13-0 65028
14
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
15
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
16
Histamine Approved, Investigational Phase 4,Phase 3,Not Applicable 51-45-6 774
17
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
18
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
19
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1177-87-3
21
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
22
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
23
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
24
Sodium Citrate Approved, Investigational Phase 4 68-04-2
25
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
26
Oxymetazoline Approved, Investigational Phase 4,Not Applicable 1491-59-4 4636
27
Phenylephrine Approved Phase 4,Not Applicable 59-42-7 6041
28
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
29
Cetirizine Approved Phase 4 83881-51-0 2678
30
Methylprednisolone Approved, Vet_approved Phase 4,Early Phase 1 83-43-2 6741
31
Methylprednisolone hemisuccinate Approved Phase 4,Early Phase 1 2921-57-5
32
Prednisolone Approved, Vet_approved Phase 4,Early Phase 1 50-24-8 5755
33
Prednisolone phosphate Approved, Vet_approved Phase 4,Early Phase 1 302-25-0
34
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
35
Clarithromycin Approved Phase 4 81103-11-9 84029
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
37 Andrographolide Investigational Phase 4 5508-58-7
38
BCG vaccine Investigational Phase 4
39
Prednisolone hemisuccinate Experimental Phase 4,Early Phase 1 2920-86-7
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2
43 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
45 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
46 Platelet Aggregation Inhibitors Phase 4,Not Applicable
47 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
48 Antirheumatic Agents Phase 4,Phase 2
49 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
50 Andrographis Phase 4

Interventional clinical trials:

(show top 50) (show all 331)
# Name Status NCT ID Phase Drugs
1 Amoxicillin Clavulanate in Treatment of Acute Otitis Media Unknown status NCT00299455 Phase 4 amoxicillin-clavulanate;Placebo
2 The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children Unknown status NCT00393159 Phase 4
3 A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis Unknown status NCT03132610 Phase 4 andrographolide sulfonate;andrographolide sulfonate simulation
4 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis Unknown status NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
5 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
6 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children Completed NCT00189462 Phase 4 Montelukast
7 Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children Completed NCT00539149 Phase 4 Amoxycillin;Placebo equivalent to amoxycillin
8 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
9 A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media Completed NCT00645112 Phase 4 cefdinir (Omnicef);azithromycin
10 A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media Completed NCT00644943 Phase 4 cefdinir (Omnicef);amoxicillin
11 Pneumococcal Vaccines Early and in Combination Completed NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
12 Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy Completed NCT01244126 Phase 4 Intranasal fentanyl;morphine IM;IV morphine
13 Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) Completed NCT00419380 Phase 4 dornase alfa (Pulmozyme®)
14 Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age Completed NCT00593502 Phase 4 oseltamivir;placebo
15 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
16 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) Completed NCT01800747 Phase 4
17 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
18 Hutterite Influenza Prevention Study Completed NCT00877396 Phase 4
19 A Study to Evaluate the Safety of HIN1 Monovalent Vaccine (MEDI3414) in Children 2 to 17 Years of Age Completed NCT00946101 Phase 4
20 A Study to Evaluate the Safety of H1N1 Monovalent Vaccine (MEDI3414) in Healthy Adults Completed NCT00945893 Phase 4
21 Live Versus Inactivated Influenza Vaccine Study in Hutterite Children Completed NCT01653015 Phase 4
22 Clinical Trial of Clinical Efficiency and Safety of Ergoferon in Treatment of Influenza Completed NCT01804946 Phase 4 Ergoferon;Oseltamivir
23 The Benefit and Harm of Fever Suppression by Antipyretics in Influenza Completed NCT01891084 Phase 4 Paracetamol;Placebo;Backup NSAID ibuprofen
24 Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children Recruiting NCT02935374 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate;Macrolide
25 Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children Recruiting NCT02653742 Phase 4 Ketorolac;Fentanyl
26 Group A Pharyngitis in Children: The GASPARD Study Recruiting NCT03264911 Phase 4 Amoxicillin or Placebo
27 Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life Active, not recruiting NCT01735084 Phase 4
28 Efficacy and Cost Analysis of Steroid Spray in Treatment of Otitis Media With Effusion Not yet recruiting NCT03590912 Phase 4 Fluticasone Nasal;Anti Histamine plus Nasal decongestents;Steroid Drug
29 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
30 Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present Not yet recruiting NCT03655665 Phase 4 Ofloxacin otic solution
31 Immunomodulatory Effect of Macrolides in Naturally Occurring Influenza Virus Infections in the Community Not yet recruiting NCT03824847 Phase 4 Clarithromycin 250 MG;Placebos
32 A Study of Tamiflu (Oseltamivir) for Treatment of Influenza With a Focus on (H1N1) 2009 Flu Strain Terminated NCT01032837 Phase 4 Oseltamivir;Oseltamivir;Placebo
33 Otiprio Versus Ciprodex Tympanostomy Tube Outcomes Withdrawn NCT03347461 Phase 4 Otiprio;Ciprodex
34 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
35 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
36 Preventing Early Childhood Caries in Indigenous Children: the Baby Teeth Talk Study Unknown status NCT02151916 Phase 3
37 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Unknown status NCT01619462 Phase 3
38 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children Completed NCT01044030 Phase 3 Xylitol syrup;Placebo
39 Improving Otitis Media Care With Clinical Decision Support Completed NCT00581711 Phase 3
40 Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Completed NCT02858388 Phase 3
41 Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence Completed NCT02345447 Phase 3 Herbal-based medication;Placebo
42 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes Completed NCT02600559 Phase 3 OTO-201 (ciprofloxacin)
43 Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children Completed NCT00781521 Phase 3 ofloxacin otic solution 0.3%
44 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00578474 Phase 3 Moxidex otic solution;Ofloxacin otic solution
45 Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children Completed NCT02541760 Phase 3 Monteleukast;Mometasone
46 Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media Completed NCT00638534 Phase 3 Telithromycin (HMR3647)
47 Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes Completed NCT00378417 Phase 3
48 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Completed NCT02044341 Phase 3 AR01;Glycerin ear drops
49 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) Completed NCT02432105 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
50 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00579189 Phase 3 Moxidex otic solution;Moxifloxacin otic solution

Search NIH Clinical Center for Otitis Media

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: otitis media

Genetic Tests for Otitis Media

Genetic tests related to Otitis Media:

# Genetic test Affiliating Genes
1 Otitis Media 30

Anatomical Context for Otitis Media

MalaCards organs/tissues related to Otitis Media:

42
Bone, Testes, Tonsil, Colon, Neutrophil, Lung, Brain

Publications for Otitis Media

Articles related to Otitis Media:

(show top 50) (show all 3946)
# Title Authors Year
1
The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children. ( 30733549 )
2019
2
Polymicrobial Anaerobic Meningitis Caused By Bacteroides Fragilis, Bacteroides Thetaiotaomicron, Fusobacterium Necrophorum And Slackia Exigua In A Patient With Mastoiditis Following Otitis Media. ( 30772448 )
2019
3
Meconium aspiration pneumonia and otitis media in two goat kids. ( 30852957 )
2019
4
Cerebral sinovenous thrombosis as a complication of otitis media. ( 30656038 )
2019
5
A mixed-methods study of the management of hearing loss associated with otitis media with effusion in children with Down syndrome. ( 30222906 )
2019
6
Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae. ( 30853830 )
2019
7
Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae isolated from the nasopharynx of children with acute otitis media. ( 30634919 )
2019
8
Epidemiology and antimicrobial susceptibility of non-typeable Haemophilus influenzae in otitis media in Taiwanese children. ( 28988664 )
2019
9
Pathology in Practice. Opportunistic Pseudomonas aeruginosa infection as cause of otitis media and labyrinthitis in immunocompetent mice. ( 30605387 )
2019
10
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. ( 30870366 )
2019
11
Otitis media and mastoiditis in temporal bones of prehistoric Chilean populations. A paleopathological and paleoepidemiological study. ( 30794067 )
2019
12
Chronic Otitis Media Associated with Cholesteatoma in a Case of the Say-Barber-Biesecker-Young-Simpson Variant of Ohdo Syndrome. ( 30739122 )
2019
13
Diagnostic Accuracy, Prescription Behavior, and Watchful Waiting Efficacy for Pediatric Acute Otitis Media. ( 30311779 )
2019
14
Periotic sensory dysfunction via postauricular approach after otitis media surgery. ( 30325498 )
2019
15
Facial canal dehiscence rate: a retrospective analysis of 372 chronic otitis media cases. ( 30421175 )
2019
16
Studying PCV impact on clinical presentation of otitis media helps to understand its pathogenesis. ( 30497832 )
2019
17
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )
2019
18
Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis. ( 30540698 )
2019
19
Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress. ( 30551453 )
2019
20
Probiotics in the treatment of otitis media. The past, the present and the future. ( 30554684 )
2019
21
Characteristics of children with refractory acute otitis media treated at the pediatric emergency department. ( 30554692 )
2019
22
Otitis media with effusion in Nigerian children with cleft palate: incidence and risk factors. ( 30598317 )
2019
23
Expression of C-type lectin receptor mRNA in otitis media with effusion and chronic otitis media with and without cholesteatoma. ( 30609964 )
2019
24
Is otitis media with effusion associated with oxidative stress? Evaluation of thiol/disulfide homeostasis. ( 30621930 )
2019
25
The Role of Routine Culture in the Treatment of Chronic Suppurative Otitis Media: Implications for the Standard of Care in Rural Areas of South Africa. ( 30626120 )
2019
26
Auditory training: Effects on auditory abilities in children with history of otitis media. ( 30639988 )
2019
27
Antibiotic Recommendations for Acute Otitis Media and Acute Bacterial Sinusitis. ( 30640191 )
2019
28
Draft Genome Sequence of Pediatric Otitis Media Isolate Streptococcus pneumoniae Strain EF3030, Which Forms In Vitro Biofilms That Closely Mimic In Vivo Biofilms. ( 30643873 )
2019
29
Bacteriology and cytology of otic exudates in 41 cavalier King Charles spaniels with primary secretory otitis media. ( 30644141 )
2019
30
Acute otitis media associated with Gradenigo syndrome and transverse sinus thrombosis: a case report. ( 30669916 )
2019
31
Pain management in acute otitis media: a qualitative study of parents' views and expectations. ( 30674279 )
2019
32
NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media. ( 30676848 )
2019
33
Fabrication of levofloxacin polyethylene glycol decorated nanoliposomes for enhanced management of acute otitis media: Statistical optimization, trans-tympanic permeation and in-vivo evaluation. ( 30684597 )
2019
34
National impact of 13-valent pneumococcal conjugate vaccine on ambulatory care visits for otitis media in children under 5 years in the United States. ( 30690309 )
2019
35
Prevalence Ratio of Otitis Media with Effusion in Laryngopharyngeal Reflux. ( 30693036 )
2019
36
Grommets in otitis media: a 25-year follow up. ( 30702024 )
2019
37
Acute otitis media in infants younger than two months of age: Epidemiologic and microbiologic characteristics in the era of pneumococcal conjugate vaccines. ( 30703661 )
2019
38
Bacterial causes of otitis media with spontaneous perforation of the tympanic membrane in the era of 13 valent pneumococcal conjugate vaccine. ( 30707730 )
2019
39
Child with intermittent diplopia after otitis media. ( 30709939 )
2019
40
Clinical outcomes of otitis media with effusion following palatoplasty in patients with incomplete cleft palate. ( 30712437 )
2019
41
Towards an optical diagnostic system for otitis media using a combination of otoscopy and spectroscopy. ( 30719866 )
2019
42
Application of pharmacokinetic/pharmacodynamic analysis to evaluate the adequacy of antimicrobial therapy for pediatric acute otitis media in Spain before and after the introduction of the PCV7 vaccine. ( 30727714 )
2019
43
Risk of occurrence and recurrence of otitis media with effusion in children suffering from cleft palate. ( 30735917 )
2019
44
Does pneumococcal conjugate vaccination affect onset and risk of first acute otitis media and recurrences? A primary care-based cohort study. ( 30738648 )
2019
45
Ossicular chain erosion in chronic otitis media patients with cholesteatoma or granulation tissue or without those: analysis of 915 cases. ( 30759279 )
2019
46
Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain. ( 30759799 )
2019
47
Changes in otitis media episodes and pressure equalization tube insertions among young children following introduction of the 13-valent pneumococcal conjugate vaccine: A birth-cohort based study. ( 30770533 )
2019
48
Etiology of acute otitis media and phenotypic-molecular characterization of Streptococcus pneumoniae isolated from children in Liuzhou, China. ( 30770718 )
2019
49
Acute otitis media in children presenting to the emergency department: Is it diagnosed and managed appropriately? ( 30788882 )
2019
50
Nasal microbial composition and chronic otitis media with effusion: A case-control study. ( 30794625 )
2019

Variations for Otitis Media

ClinVar genetic disease variations for Otitis Media:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 A2ML1 NM_144670.5(A2ML1): c.2478_2485dupGGCTAAAT (p.Ser829Trpfs) duplication Pathogenic,risk factor rs863224951 GRCh37 Chromosome 12, 9004820: 9004827
2 A2ML1 NM_144670.5(A2ML1): c.2478_2485dupGGCTAAAT (p.Ser829Trpfs) duplication Pathogenic,risk factor rs863224951 GRCh38 Chromosome 12, 8852224: 8852231
3 A2ML1 NM_144670.5(A2ML1): c.2677C> T (p.Arg893Ter) single nucleotide variant Uncertain significance rs199651558 GRCh38 Chromosome 12, 8854214: 8854214
4 A2ML1 NM_144670.5(A2ML1): c.2677C> T (p.Arg893Ter) single nucleotide variant Uncertain significance rs199651558 GRCh37 Chromosome 12, 9006810: 9006810

Expression for Otitis Media

LifeMap Discovery
Genes differentially expressed in tissues of Otitis Media patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PNLIPRP3 pancreatic lipase-related protein 3 Blood - 6.47 0.003
2 FAM20A family with sequence similarity 20, member A Blood + 3.09 0.015
Search GEO for disease gene expression data for Otitis Media.

Pathways for Otitis Media

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CCL11 CD79A CXCL8 IGHE IL10 IL1B
2
Show member pathways
13.44 CCL11 CXCL8 IL10 IL1B IL6 TLR2
3
Show member pathways
13.37 CCL11 CXCL8 IGHE IL10 IL1B IL6
4
Show member pathways
13.21 CXCL8 IL10 IL1B IL6 MBL2 TLR2
5
Show member pathways
12.98 CXCL8 IL1B IL6 TLR2 TLR4 TNF
6
Show member pathways
12.92 CCL11 CXCL8 IL10 IL1B IL6 RNASE3
7
Show member pathways
12.78 CXCL8 IL1B IL6 TLR4 TNF
8
Show member pathways
12.72 IL1B IL6 TLR2 TLR4 TNF
9
Show member pathways
12.64 IL10 IL1B IL6 TLR2 TLR4 TNF
10
Show member pathways
12.63 CXCL8 IL1B IL6 TLR2 TLR4 TNF
11 12.6 CD79A IL10 IL1B TLR2 TNF
12
Show member pathways
12.43 IL10 IL1B IL6 TNF
13
Show member pathways
12.36 CXCL8 IL1B IL6 TLR4 TNF
14
Show member pathways
12.35 ALB IL1B IL6 TNF
15
Show member pathways
12.32 CXCL8 IL6 TLR2 TLR4 TNF
16
Show member pathways
12.31 IL10 IL1B TLR2 TLR4 TNF
17
Show member pathways
12.3 CXCL8 IL10 IL1B IL6 TNF
18 12.28 IL10 IL1B IL6 TLR2 TLR4 TNF
19
Show member pathways
12.25 CXCL8 IL1B IL6 MUC5AC MUC5B TLR2
20
Show member pathways
12.24 IL10 IL1B IL6 TNF
21 12.23 CXCL8 IL10 IL1B IL6 TNF
22 12.22 IL6 TLR2 TLR4 TNF
23
Show member pathways
12.19 CCL11 CXCL8 IL1B IL6 TLR2 TLR4
24
Show member pathways
12.19 CCL11 CXCL8 IL1B IL6 MUC5AC MUC5B
25
Show member pathways
12.12 IL10 IL1B IL6 TLR2 TLR4 TNF
26
Show member pathways
12.11 CCL11 CXCL8 IL10 IL1B IL6
27
Show member pathways
12.1 IL1B IL6 TLR2 TLR4 TNF
28 12.07 CXCL8 IL1B IL6 TLR4 TNF
29 12.04 CD79A IL10 IL6 TNF
30 11.96 CXCL8 IL1B IL6 TNF
31 11.94 CXCL8 IL1B TLR4 TNF
32 11.91 CXCL8 IL1B IL6 TLR2 TLR4 TNF
33 11.89 CXCL8 IL1B IL6 TLR4
34
Show member pathways
11.87 CXCL8 IL6 TLR4
35 11.82 IL10 IL1B IL6 TNF
36 11.79 IL10 IL1B TNF
37 11.79 CCL11 IL10 IL1B IL6 TNF
38 11.76 CXCL8 IL10 IL1B IL6 TLR4 TNF
39 11.76 CCL11 CXCL8 IGHE IL10 IL1B IL6
40
Show member pathways
11.72 CXCL8 IL1B IL6 TNF
41 11.68 CCL11 IGHE IL10
42 11.64 CCL11 CXCL8 IL1B IL6 MUC5B TNF
43 11.6 CXCL8 IL10 IL1B IL6 TNF
44 11.59 IL1B TLR2 TLR4 TNF
45 11.54 CCL11 CXCL8 IL6
46 11.54 CXCL8 IL1B IL6 TLR2 TLR4 TNF
47 11.52 IL1B IL6 TNF
48 11.48 CXCL8 IL10 IL1B IL6 TLR2 TLR4
49 11.45 IL10 IL1B IL6 TNF
50 11.44 IL10 IL1B IL6 TLR4 TNF

GO Terms for Otitis Media

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 A2ML1 ALB CCL11 CXCL8 IGHE IL10
2 extracellular space GO:0005615 9.4 A2ML1 ALB CCL11 CXCL8 IL10 IL1B

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.97 IGHE IL10 MBL2 RNASE3 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.96 IL10 IL1B TLR2 TLR4
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL1B IL6 TLR2 TLR4 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL10 IL1B IL6 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.88 IL6 RNASE3 TLR4
6 neutrophil chemotaxis GO:0030593 9.88 CCL11 CXCL8 IL1B
7 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 CCL11 TLR4 TNF
9 positive regulation of inflammatory response GO:0050729 9.87 TLR2 TLR4 TNF
10 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 IL10 IL1B IL6 TLR4 TNF
11 defense response to Gram-positive bacterium GO:0050830 9.83 IL6 MBL2 RNASE3 TLR2 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.82 IL1B TLR4 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IL1B TLR4 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL1B TLR2 TLR4 TNF
15 positive regulation of phagocytosis GO:0050766 9.8 IL1B MBL2 TNF
16 cytokine-mediated signaling pathway GO:0019221 9.8 CCL11 CXCL8 IGHE IL10 IL1B IL6
17 negative regulation of interleukin-6 production GO:0032715 9.78 IL10 TLR4 TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TLR4 TNF
19 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
20 positive regulation of glial cell proliferation GO:0060252 9.75 IL1B IL6 TNF
21 response to glucocorticoid GO:0051384 9.74 IL10 IL6 TNF
22 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 MBL2 TNF
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
24 regulation of cytokine secretion GO:0050707 9.71 TLR2 TLR4
25 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10 TLR2
26 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TLR4 TNF
27 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
28 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 TLR4
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
30 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
31 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 TLR4
34 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 IL10 TNF
36 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
37 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
38 positive regulation of neuroinflammatory response GO:0150078 9.63 IL1B IL6 TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
40 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
41 positive regulation of chemokine production GO:0032722 9.62 IL6 TLR2 TLR4 TNF
42 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.6 TLR2 TLR4
43 inflammatory response GO:0006954 9.56 CCL11 CXCL8 IL10 IL1B IL6 TLR2
44 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B IL6 TLR2 TLR4 TNF
45 chronic inflammatory response to antigenic stimulus GO:0002439 9.34 TNF
46 immune response GO:0006955 9.28 CCL11 CXCL8 IGHE IL10 IL1B IL6
47 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 IL10 IL1B IL6 SHOX TLR2 TLR4
48 innate immune response GO:0045087 10.1 IGHE MBL2 RNASE3 TLR2 TLR4
49 negative regulation of cell proliferation GO:0008285 10.08 CXCL8 IL10 IL1B IL6 TLR2
50 positive regulation of gene expression GO:0010628 10.07 IL1B IL6 TLR2 TLR4 TNF

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
2 lipopolysaccharide binding GO:0001530 9.13 RNASE3 TLR2 TLR4
3 cytokine activity GO:0005125 9.1 CCL11 CXCL8 IL10 IL1B IL6 TNF

Sources for Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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