Aliases & Classifications for Otomycosis

MalaCards integrated aliases for Otomycosis:

Name: Otomycosis 12 44 15 73
Singapore Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050147
MeSH 44 D059249
UMLS 73 C0029895

Summaries for Otomycosis

Disease Ontology : 12 An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

MalaCards based summary : Otomycosis, also known as singapore ear, is related to otitis externa and chronic fungal otitis externa, and has symptoms including earache An important gene associated with Otomycosis is CALM3 (Calmodulin 3), and among its related pathways/superpathways are Integrin Pathway and CCR5 Pathway in Macrophages. The drugs Clotrimazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testes.

Wikipedia : 76 Otomycosis is a fungal ear infection, a superficial mycotic infection of the outer ear canal. It is... more...

Related Diseases for Otomycosis

Diseases related to Otomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 otitis externa 30.1 CALM1 CALM2 CALM3
2 chronic fungal otitis externa 11.1
3 schizophrenia 10.0
4 coccidioidomycosis 10.0
5 middle ear disease 10.0
6 long qt syndrome 10.0 CALM1 CALM2 CALM3
7 long qt syndrome 15 10.0 CALM1 CALM2 CALM3
8 long qt syndrome 1 10.0 CALM1 CALM2 CALM3
9 external ear disease 10.0 CALM1 CALM2 CALM3
10 emery-dreifuss muscular dystrophy 5, autosomal dominant 10.0 CALM1 CALM2 CALM3
11 sporotrichosis 10.0 CALM1 CALM2 CALM3
12 spontaneous ocular nystagmus 10.0 CALM1 CALM2 CALM3
13 deafness, autosomal recessive 44 10.0 CALM1 CALM2 CALM3
14 acute dacryocystitis 10.0 CALM1 CALM2 CALM3
15 dystonia 24 10.0 CALM1 CALM2 CALM3
16 gestational choriocarcinoma 10.0 CALM1 CALM2 CALM3
17 triosephosphate isomerase deficiency 10.0 CALM1 CALM2 CALM3
18 leber congenital amaurosis 2 10.0 CALM1 CALM2 CALM3
19 primary systemic mycosis 10.0 CALM1 CALM2 CALM3
20 clear cell acanthoma 10.0 CALM1 CALM2 CALM3
21 cardiomyopathy, dilated, 1a 10.0 CALM1 CALM2 CALM3
22 cardiomyopathy, dilated, 1p 10.0 CALM1 CALM2 CALM3
23 deafness, autosomal dominant 2a 10.0 CALM1 CALM2 CALM3
24 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 9.9 CALM1 CALM2 CALM3
25 ceroid lipofuscinosis, neuronal, 11 9.9 CALM1 CALM2 CALM3
26 primary cutaneous amyloidosis 9.9 CALM1 CALM2 CALM3
27 tinea unguium 9.9 CALM1 CALM2 CALM3 CBS
28 phaeohyphomycosis 9.9 CALM1 CALM2 CALM3 CBS
29 catecholaminergic polymorphic ventricular tachycardia 9.9 CALM1 CALM2 CALM3
30 cardiac arrest 9.8 CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to Otomycosis:



Diseases related to Otomycosis

Symptoms & Phenotypes for Otomycosis

UMLS symptoms related to Otomycosis:


earache

Drugs & Therapeutics for Otomycosis

Drugs for Otomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 3,Not Applicable 23593-75-1 2812
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
4 Pharmaceutical Solutions Phase 3,Not Applicable
5 Hormones Phase 3,Phase 2
6 Hormone Antagonists Phase 3,Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
8 Gastrointestinal Agents Phase 3
9 Antineoplastic Agents, Hormonal Phase 3
10
protease inhibitors Phase 3
11 Antiemetics Phase 3
12 glucocorticoids Phase 3
13 HIV Protease Inhibitors Phase 3
14 BB 1101 Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Autonomic Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
19 Cytochrome P-450 CYP3A Inhibitors Phase 2
20 Cytochrome P-450 Enzyme Inhibitors Phase 2
21 Anti-Infective Agents Phase 2
22 Steroid Synthesis Inhibitors Phase 2
23 Antifungal Agents Phase 2
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
25
Ethanol Approved Not Applicable 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis Completed NCT01993823 Phase 3 G238;Clotrimazole
2 SVT-15652 Otic Solution for the Treatment of Otomycosis Not yet recruiting NCT03686384 Phase 3 SVT-15652;Placebo
3 SVT-15652 Otic Solution for the Treatment of Otomycosis. Not yet recruiting NCT03686397 Phase 3 SVT-15652;Placebo
4 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
5 Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis Recruiting NCT03130738 Phase 2 7-Day Miconazole Oil (Miconazole 2%);14-Day Miconazole Oil (Miconazole 2%);14-Day Placebo - Oil Vehicle
6 Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients Completed NCT01547221 Not Applicable clotrimazole;3% Boric acid

Search NIH Clinical Center for Otomycosis

Cochrane evidence based reviews: otomycosis

Genetic Tests for Otomycosis

Anatomical Context for Otomycosis

MalaCards organs/tissues related to Otomycosis:

41
Testes

Publications for Otomycosis

Articles related to Otomycosis:

(show top 50) (show all 148)
# Title Authors Year
1
Species identification and in vitro antifungal susceptibility testing of Aspergillus section Nigri strains isolated from otomycosis patients. ( 29540288 )
2018
2
Successful treatment of a recurrent AspergillusA niger otomycosis with local application of voriconazole. ( 29673769 )
2018
3
Efficacy and safety of eberconazole 1% otic solution compared to clotrimazole 1% solution in patients with otomycosis. ( 29551350 )
2018
4
Assessment of Response to Treatment in Patients with Otomycosis. ( 29387663 )
2018
5
Self-injury in schizophrenia as predisposing factor for otomycosis. ( 30069425 )
2018
6
Effect of combination therapy with ceftizoxime and clotrimazole in the treatment of otomycosis. ( 30186989 )
2018
7
The Molecular Identification and Antifungal Susceptibilities of Aspergillus Species Causing Otomycosis in Tochigi, Japan. ( 30291485 )
2018
8
Identification of Fungal Pathogens in Otomycosis and Their Drug Sensitivity: Our Experience. ( 30357045 )
2018
9
Single Dose Topical Application of Clotrimazole for the Treatment of Otomycosis: Is This Enough? ( 30518195 )
2018
10
Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. ( 28549873 )
2017
11
A case of bilateral otomycosis associated with Aspergillus flavus and A.A terreus in Taiwan. ( 28501466 )
2017
12
Otomycosis in Damascus, Syria: Etiology and clinical features. ( 29707671 )
2017
13
Otomycosis in immunocompetent patients: Clinical and mycological features. Our experience with 40 cases. ( 28834405 )
2017
14
Antifungal Effect of Malaysian Aloe vera Leaf Extract on Selected Fungal Species of Pathogenic Otomycosis Species in In Vitro Culture Medium. ( 28042402 )
2017
15
Otomycosis in a Rural Community Attending a Tertiary Care Hospital: Assessment of Risk Factors and Identification of Fungal and Bacterial Agents. ( 28764159 )
2017
16
A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. ( 26600419 )
2016
17
Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. ( 27127015 )
2016
18
Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. ( 27477534 )
2016
19
Scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: Management of this rare entity. ( 26298623 )
2015
20
Lamisil, a potent alternative antifungal drug for otomycosis. ( 28680976 )
2015
21
Otomycosis in Adolescent Patients Referred to the Therapeutic Centers in Babol City, Iran. ( 26060563 )
2015
22
Etiologic Agents of Otomycosis in the North-Western Area of Iran. ( 26495108 )
2015
23
Epidemiology, causative agents, and risk factors affecting human otomycosis infections. ( 26422852 )
2015
24
Otomycosis in Iran: A Review. ( 25633436 )
2015
25
Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis? ( 25621236 )
2015
26
Otomycosis in Jos: Predisposing factors and Management. ( 26690089 )
2014
27
Treatment of refractory Aspergillus otomycosis with voriconazole: case series and review. ( 24909800 )
2014
28
Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. ( 24949016 )
2014
29
Otomycosis; clinical features, predisposing factors and treatment implications. ( 24948980 )
2014
30
Efficacy of topical clotrimazole in treatment of otomycosis. ( 25098061 )
2013
31
Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ( 23984100 )
2013
32
Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents. ( 23595615 )
2013
33
Prevalence of otomycosis in Khouzestan Province, south-west Iran. ( 23164073 )
2013
34
Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. ( 21895787 )
2012
35
Otomycosis in immunocompetent and immunocompromised patients: comparative study and literature review. ( 22430336 )
2012
36
Otomycosis with Perforated Tympanic Membrane: Self medication with Topical Antifungal Solution versus Medicated Ear Wick. ( 23267306 )
2012
37
Molecular identification and antifungal susceptibilities of black Aspergillus isolates from otomycosis cases in Hungary. ( 22359155 )
2012
38
Otomycosis in Shanghai: aetiology, clinical features and therapy. ( 21999222 )
2012
39
Antibiotic resistance and otomycosis in the draining ear: culture results by diagnosis. ( 21041003 )
2011
40
A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis). ( 22529649 )
2011
41
Otomycosis due to filamentous fungi. ( 21499908 )
2011
42
Otomycosis in central iran: a clinical and mycological study. ( 22737432 )
2011
43
Chronic otomycosis due to malassezia spp. ( 20606976 )
2010
44
Prevalence of otomycosis in Ibadan: a review of laboratory reports. ( 22420052 )
2010
45
Otomycosis due to Aspergillus spp. in a dog: case report and literature review. ( 20492628 )
2010
46
Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus. ( 20409075 )
2010
47
Otomycosis: Diagnosis and treatment. ( 20347664 )
2010
48
Otomycosis: a retrospective study. ( 19649486 )
2009
49
Otomycosis in western Nigeria. ( 18076598 )
2008
50
Ototopical antifungals and otomycosis: a review. ( 18279975 )
2008

Variations for Otomycosis

Expression for Otomycosis

Search GEO for disease gene expression data for Otomycosis.

Pathways for Otomycosis

Pathways related to Otomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 CALM1 CALM2 CALM3 CD99 CXCL14
2
Show member pathways
12.76 CALM1 CALM2 CALM3 CXCL14
3
Show member pathways
12.45 CALM1 CALM2 CALM3
4
Show member pathways
12.43 CALM1 CALM2 CALM3
5
Show member pathways
12.43 CALM1 CALM2 CALM3
6
Show member pathways
12.42 CALM1 CALM2 CALM3
7
Show member pathways
12.41 CALM1 CALM2 CALM3
8
Show member pathways
12.39 CALM1 CALM2 CALM3
9
Show member pathways
12.34 CALM1 CALM2 CALM3
10
Show member pathways
12.34 CALM1 CALM2 CALM3
11
Show member pathways
12.33 CALM1 CALM2 CALM3
12
Show member pathways
12.32 CALM1 CALM2 CALM3
13
Show member pathways
12.32 CALM1 CALM2 CALM3
14
Show member pathways
12.3 CALM1 CALM2 CALM3
15
Show member pathways
12.29 CALM1 CALM2 CALM3
16
Show member pathways
12.28 CALM1 CALM2 CALM3
17 12.27 CALM1 CALM2 CALM3
18
Show member pathways
12.26 CALM1 CALM2 CALM3
19
Show member pathways
12.25 CALM1 CALM2 CALM3
20
Show member pathways
12.23 CALM1 CALM2 CALM3
21
Show member pathways
12.23 CALM1 CALM2 CALM3
22
Show member pathways
12.22 CALM1 CALM2 CALM3
23
Show member pathways
12.22 CALM1 CALM2 CALM3
24
Show member pathways
12.2 CALM1 CALM2 CALM3
25
Show member pathways
12.17 CALM1 CALM2 CALM3
26
Show member pathways
12.16 CALM1 CALM2 CALM3
27
Show member pathways
12.14 CALM1 CALM2 CALM3
28 12.13 CALM1 CALM2 CALM3
29
Show member pathways
12.11 CALM1 CALM2 CALM3
30
Show member pathways
12.11 CALM1 CALM2 CALM3
31
Show member pathways
12.09 CALM1 CALM2 CALM3
32
Show member pathways
12.08 CALM1 CALM2 CALM3
33
Show member pathways
12.07 CALM1 CALM2 CALM3
34 12.06 CALM1 CALM2 CALM3
35
Show member pathways
12.05 CALM1 CALM2 CALM3
36
Show member pathways
12.03 CALM1 CALM2 CALM3
37
Show member pathways
12.03 CALM1 CALM2 CALM3 CD99 CXCL14
38 11.99 CALM1 CALM2 CALM3
39 11.99 CALM1 CALM2 CALM3
40
Show member pathways
11.92 CALM1 CALM2 CALM3
41
Show member pathways
11.91 CALM1 CALM2 CALM3
42
Show member pathways
11.88 CALM1 CALM2 CALM3
43
Show member pathways
11.85 CALM1 CALM2 CALM3
44 11.83 CALM1 CALM2 CALM3
45 11.82 CALM1 CALM2 CALM3
46 11.8 CALM1 CALM2 CALM3
47
Show member pathways
11.8 CALM1 CALM2 CALM3
48
Show member pathways
11.77 CALM1 CALM2 CALM3
49
Show member pathways
11.76 CALM1 CALM2 CALM3
50
Show member pathways
11.69 CALM1 CALM2 CALM3

GO Terms for Otomycosis

Cellular components related to Otomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.61 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
3 myelin sheath GO:0043209 9.54 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
5 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
6 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
7 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
8 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Otomycosis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.78 CALM1 CALM2 CALM3
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
5 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
6 regulation of heart rate GO:0002027 9.72 CALM1 CALM2 CALM3
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 positive regulation of protein autophosphorylation GO:0031954 9.69 CALM1 CALM2 CALM3
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
11 regulation of synaptic vesicle exocytosis GO:2000300 9.65 CALM1 CALM3
12 response to amphetamine GO:0001975 9.65 CALM1 CALM3
13 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
14 activation of adenylate cyclase activity GO:0007190 9.64 CALM1 CALM3
15 positive regulation of DNA binding GO:0043388 9.64 CALM2 CALM3
16 positive regulation of nitric-oxide synthase activity GO:0051000 9.63 CALM1 CALM3
17 response to corticosterone GO:0051412 9.63 CALM1 CALM3
18 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
19 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.62 CALM1 CALM3
20 regulation of synaptic vesicle endocytosis GO:1900242 9.62 CALM1 CALM3
21 establishment of protein localization to membrane GO:0090150 9.61 CALM1 CALM3
22 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
23 regulation of high voltage-gated calcium channel activity GO:1901841 9.6 CALM1 CALM3
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 establishment of protein localization to mitochondrial membrane GO:0090151 9.56 CALM1 CALM3
26 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
27 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
28 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
29 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
30 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
31 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otomycosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.72 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.67 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.61 CALM1 CALM2 CALM3
4 enzyme regulator activity GO:0030234 9.54 CALM1 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
6 phosphatidylinositol 3-kinase binding GO:0043548 9.52 CALM1 CALM3
7 nitric-oxide synthase binding GO:0050998 9.51 CALM1 CALM3
8 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
9 calcium channel inhibitor activity GO:0019855 9.48 CALM1 CALM2
10 nitric-oxide synthase regulator activity GO:0030235 9.46 CALM1 CALM3
11 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.4 CALM1 CALM3
13 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
14 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
15 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3
16 protein binding GO:0005515 10.21 CALM1 CALM2 CALM3 CBS CD99 CXCL14

Sources for Otomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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