Aliases & Classifications for Otomycosis

MalaCards integrated aliases for Otomycosis:

Name: Otomycosis 12 44 15 72
Singapore Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050147
MeSH 44 D059249
UMLS 72 C0029895

Summaries for Otomycosis

Disease Ontology : 12 An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

MalaCards based summary : Otomycosis, also known as singapore ear, is related to chronic fungal otitis externa and otitis externa, and has symptoms including earache An important gene associated with Otomycosis is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1). The drugs Clotrimazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testes and myeloid.

Wikipedia : 75 Otomycosis is a fungal ear infection, a superficial mycotic infection of the outer ear canal. It is more... more...

Related Diseases for Otomycosis

Diseases related to Otomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 chronic fungal otitis externa 11.3
2 otitis externa 10.7
3 otitis media 10.4
4 mastoiditis 10.3
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
6 bacterial infectious disease 10.2
7 suppurative otitis media 10.2
8 chronic purulent otitis media 10.2
9 dermatomycosis 10.2
10 dermatitis 10.2
11 auditory system disease 10.2
12 dermatophytosis 10.2
13 candida glabrata 10.2
14 schizophrenia 10.1
15 aspergillosis 10.1
16 superficial mycosis 10.1
17 cutaneous candidiasis 10.1
18 cholesteatoma of middle ear 10.1
19 coccidioidomycosis 10.1
20 candidiasis 10.1
21 middle ear disease 10.1
22 end stage renal failure 10.1
23 tinea nigra 10.1
24 pityriasis versicolor 10.1
25 exophthalmos 9.8 RHNO1 FLNA

Graphical network of the top 20 diseases related to Otomycosis:



Diseases related to Otomycosis

Symptoms & Phenotypes for Otomycosis

UMLS symptoms related to Otomycosis:


earache

Drugs & Therapeutics for Otomycosis

Drugs for Otomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
4 Pharmaceutical Solutions Phase 3
5 Hormones Phase 3
6 Hormone Antagonists Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
8 Antiemetics Phase 3
9 Gastrointestinal Agents Phase 3
10 Anti-Inflammatory Agents Phase 3
11 HIV Protease Inhibitors Phase 3
12
protease inhibitors Phase 3
13 glucocorticoids Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Antineoplastic Agents, Hormonal Phase 3
16 BB 1101 Phase 3
17 Autonomic Agents Phase 3
18
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
19 Anti-Infective Agents Phase 2
20 14-alpha Demethylase Inhibitors Phase 2
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
22 Cytochrome P-450 CYP3A Inhibitors Phase 2
23 Steroid Synthesis Inhibitors Phase 2
24 Antifungal Agents Phase 2
25 Cytochrome P-450 Enzyme Inhibitors Phase 2
26
Ethanol Approved 64-17-5 702
27
carbamide peroxide Approved 124-43-6
28 Anti-Infective Agents, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III, Multicenter, Randomized, Double-blind, Parallel Group, Active Treatment-controlled Study Assessing the Safety and Efficacy of G238 Compared to Clotrimazole 1% Otic Solution in Patients With Otomycosis Completed NCT01993823 Phase 3 G238;Clotrimazole
2 A Phase III, Multicenter, Randomized, Double-Blind Clinical Trial to Assess the Efficacy and Safety of SVT-15652 Otic Solution Complared to Placebo for the Treatment of Fungal Otitis Externa (Otomycosis). Not yet recruiting NCT03686397 Phase 3 SVT-15652;Placebo
3 A Phase III, Multicenter, Randomized, Double-Blind Clinical Trial to Assess the Efficacy and Safety of SVT-15652 Otic Solution Compared to Placebo for the Treatment of Fungal Otitis Externa (Otomycosis) Not yet recruiting NCT03686384 Phase 3 SVT-15652;Placebo
4 A Multi-Center, Randomized, Double-Masked, Vehicle-Controlled Clinical Study Evaluating the Efficacy Of FST-201 (Dexamethasone 0.1%) Otic Suspension in Subjects With Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
5 Dose-Ranging Study of the Efficacy and Safety of Miconazole Oil Used for 7 or 14 Days Compared With Vehicle in the Treatment of Otomycosis Recruiting NCT03130738 Phase 2 7-Day Miconazole Oil (Miconazole 2%);14-Day Miconazole Oil (Miconazole 2%);14-Day Placebo - Oil Vehicle
6 Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients: a Randomized Controlled Trial Completed NCT01547221 clotrimazole;3% Boric acid

Search NIH Clinical Center for Otomycosis

Cochrane evidence based reviews: otomycosis

Genetic Tests for Otomycosis

Anatomical Context for Otomycosis

MalaCards organs/tissues related to Otomycosis:

41
Testes, Myeloid

Publications for Otomycosis

Articles related to Otomycosis:

(show top 50) (show all 276)
# Title Authors PMID Year
1
Diagnosis and treatment of otomycosis in southern China. 38
31368588 2019
2
Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. 38
29671212 2019
3
Molecular epidemiology of otomycosis in Isfahan revealed a large diversity in causative agents. 38
31063125 2019
4
Otomycosis With Tympanic Membrane Perforation: A Review of the Literature. 38
31142158 2019
5
Clinical and microbial epidemiology of otomycosis in the city of Yasuj, southwest Iran, revealing Aspergillus tubingensis as the dominant causative agent. 38
30801244 2019
6
The Inhibitory Effect of Essential Oils on Rhizopus stolonifer, Trichophyton mentagrophytes, and Microsporum gypseum. 38
30690523 2019
7
Bayesian analysis of two methods MALDI-TOF-MS system and culture test in otomycosis infection. 38
30775695 2019
8
Investigation of Etiologic Agents and Clinical Presentations of Otomycosis at a Tertiary Referral Center in Tehran, Iran. 38
31205888 2019
9
Efficacy of topical clotrimazole vs. topical tolnaftate in the treatment of otomycosis. A randomized controlled clinical trial. 38
30826311 2019
10
The Molecular Identification and Antifungal Susceptibilities of Aspergillus Species Causing Otomycosis in Tochigi, Japan. 38
30291485 2019
11
Candida auris otomycosis in Iran and review of recent literature. 38
30585653 2019
12
Single Dose Topical Application of Clotrimazole for the Treatment of Otomycosis: Is This Enough? 38
30518195 2019
13
Identification of Fungal Pathogens in Otomycosis and Their Drug Sensitivity: Our Experience. 38
30357045 2018
14
A search for new otomycotic species and their sensitivity to different antifungals. 38
30713753 2018
15
Self-injury in schizophrenia as predisposing factor for otomycosis. 38
30069425 2018
16
Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. 38
28549873 2018
17
Successful treatment of a recurrent Aspergillus niger otomycosis with local application of voriconazole. 38
29673769 2018
18
Species identification and in vitro antifungal susceptibility testing of Aspergillus section Nigri strains isolated from otomycosis patients. 38
29540288 2018
19
Efficacy and safety of eberconazole 1% otic solution compared to clotrimazole 1% solution in patients with otomycosis. 38
29551350 2018
20
Distal Lateral Subungual Onychomycosis Owing to Tritirachium oryzae: A Bystander or Invader? 38
29164433 2018
21
Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application. 38
29301391 2018
22
Povidone iodine soaked gelfoam for the treatment of recalcitrant otomycosis - Our experiences at a tertiary care teaching hospital of eastern India. 38
29223643 2018
23
Chronic mucocutaneous candidiasis, a case study and literature review. 38
29500032 2018
24
Effect of combination therapy with ceftizoxime and clotrimazole in the treatment of otomycosis. 38
30186989 2018
25
Otomycosis in immunocompetent patients: Clinical and mycological features. Our experience with 40 cases. 38
28834405 2018
26
[Otomycosis: the modern view of etiology and management]. 38
29488497 2018
27
Assessment of Response to Treatment in Patients with Otomycosis. 38
29387663 2018
28
Otomycosis in Damascus, Syria: Etiology and clinical features. 38
29707671 2017
29
A case of bilateral otomycosis associated with Aspergillus flavus and A. terreus in Taiwan. 38
28501466 2017
30
Epidemiology of dermatomycoses in Kerman province, southeast of Iran: A 10-years retrospective study (2004-2014). 38
28757272 2017
31
Otomycosis in a Rural Community Attending a Tertiary Care Hospital: Assessment of Risk Factors and Identification of Fungal and Bacterial Agents. 38
28764159 2017
32
The Effect of Nystatin Solution on Otoacoustic Emissions in Rats. 38
27819649 2017
33
Antifungal Effect of Malaysian Aloe vera Leaf Extract on Selected Fungal Species of Pathogenic Otomycosis Species in In Vitro Culture Medium. 38
28042402 2017
34
Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. 38
27477534 2016
35
Conventional Morphology Versus PCR Sequencing, rep-PCR, and MALDI-TOF-MS for Identification of Clinical Aspergillus Isolates Collected Over a 2-Year Period in a University Hospital at Kayseri, Turkey. 38
26926455 2016
36
A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. 38
26600419 2016
37
Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. 38
27127015 2016
38
In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex. 38
26615417 2016
39
Aspergillus otitis in small animals--a retrospective study of 17 cases. 38
26748885 2016
40
The Effects of Topical Burow's and Castellani's Solutions on the Middle Ear Mucosa of Rats. 38
26915159 2015
41
Scedosporium apiospermum Otitis Complicated by a Temporomandibular Arthritis: A Case Report and Mini-Review. 38
26105580 2015
42
Scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: Management of this rare entity. 38
26298623 2015
43
Etiologic Agents of Otomycosis in the North-Western Area of Iran. 38
26495108 2015
44
[Clinical analysis of external ear canal coating by otoendoscopy on otomycosis external with triamcinolone acetonide and econazole nitrate cream]. 38
26672250 2015
45
Otomycosis in iran: a review. 38
25633436 2015
46
Otomycosis in Adolescent Patients Referred to the Therapeutic Centers in Babol City, Iran. 38
26060563 2015
47
Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis? 38
25621236 2015
48
Lamisil, a potent alternative antifungal drug for otomycosis. 38
28680976 2015
49
Epidemiology, causative agents, and risk factors affecting human otomycosis infections. 38
26422852 2015
50
[The first case of persistent vaginitis due to Aspergillus protuberus in an immunocompetent patient]. 38
25706739 2015

Variations for Otomycosis

Expression for Otomycosis

Search GEO for disease gene expression data for Otomycosis.

Pathways for Otomycosis

GO Terms for Otomycosis

Sources for Otomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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