Aliases & Classifications for Otomycosis

MalaCards integrated aliases for Otomycosis:

Name: Otomycosis 12 15 73
Singapore Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050147
UMLS 73 C0029895

Summaries for Otomycosis

Disease Ontology : 12 An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

MalaCards based summary : Otomycosis, also known as singapore ear, is related to otitis externa and chronic fungal otitis externa, and has symptoms including earache An important gene associated with Otomycosis is CALM3 (Calmodulin 3), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Clotrimazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotype is Reduced mammosphere formation.

Wikipedia : 76 Otomycosis is a fungal ear infection, a superficial mycotic infection of the outer ear canal. It is more... more...

Related Diseases for Otomycosis

Graphical network of the top 20 diseases related to Otomycosis:



Diseases related to Otomycosis

Symptoms & Phenotypes for Otomycosis

UMLS symptoms related to Otomycosis:


earache

GenomeRNAi Phenotypes related to Otomycosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CALM3 CBS FLNA CALM1 CALM2

Drugs & Therapeutics for Otomycosis

Drugs for Otomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 3,Not Applicable 23593-75-1 2812
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3 Pharmaceutical Solutions Phase 3,Not Applicable
4 Autonomic Agents Phase 3,Not Applicable
5 Peripheral Nervous System Agents Phase 3,Not Applicable
6 Hormone Antagonists Phase 3,Phase 2
7 Hormones Phase 3,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
9 Antiemetics Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Antineoplastic Agents, Hormonal Phase 3
12 BB 1101 Phase 3
13 Dexamethasone acetate Phase 3 1177-87-3
14 Gastrointestinal Agents Phase 3
15 glucocorticoids Phase 3
16 HIV Protease Inhibitors Phase 3
17
protease inhibitors Phase 3
18
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
19 Antifungal Agents Phase 2
20 Anti-Infective Agents Phase 2
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
22 Cytochrome P-450 CYP3A Inhibitors Phase 2
23 Cytochrome P-450 Enzyme Inhibitors Phase 2
24 Steroid Synthesis Inhibitors Phase 2
25
Ephedrine Approved Not Applicable 299-42-3 9294
26
Ethanol Approved Not Applicable 64-17-5 702
27
Pseudoephedrine Approved Not Applicable 90-82-4 7028
28 Nasal Decongestants Not Applicable
29 Ophthalmic Solutions Not Applicable
30 Respiratory System Agents Not Applicable
31 Tetrahydrozoline Not Applicable
32 Vasoconstrictor Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis Completed NCT01993823 Phase 3 G238;Clotrimazole
2 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
3 Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis Recruiting NCT03130738 Phase 2 7-Day Miconazole Oil;14-Day Miconazole Oil;14-Day Placebo - Oil Vehicle
4 Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients Completed NCT01547221 Not Applicable clotrimazole;3% Boric acid

Search NIH Clinical Center for Otomycosis

Genetic Tests for Otomycosis

Anatomical Context for Otomycosis

MalaCards organs/tissues related to Otomycosis:

41
Testes

Publications for Otomycosis

Articles related to Otomycosis:

(show top 50) (show all 142)
# Title Authors Year
1
Species identification and in vitro antifungal susceptibility testing of Aspergillus section Nigri strains isolated from otomycosis patients. ( 29540288 )
2018
2
Successful treatment of a recurrent AspergillusA niger otomycosis with local application of voriconazole. ( 29673769 )
2018
3
Efficacy and safety of eberconazole 1% otic solution compared to clotrimazole 1% solution in patients with otomycosis. ( 29551350 )
2018
4
Assessment of Response to Treatment in Patients with Otomycosis. ( 29387663 )
2018
5
Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. ( 28549873 )
2017
6
A case of bilateral otomycosis associated with Aspergillus flavus and A.A terreus in Taiwan. ( 28501466 )
2017
7
Otomycosis in Damascus, Syria: Etiology and clinical features. ( 29707671 )
2017
8
Otomycosis in immunocompetent patients: Clinical and mycological features. Our experience with 40 cases. ( 28834405 )
2017
9
Antifungal Effect of Malaysian Aloe vera Leaf Extract on Selected Fungal Species of Pathogenic Otomycosis Species in In Vitro Culture Medium. ( 28042402 )
2017
10
Otomycosis in a Rural Community Attending a Tertiary Care Hospital: Assessment of Risk Factors and Identification of Fungal and Bacterial Agents. ( 28764159 )
2017
11
A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. ( 26600419 )
2016
12
Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. ( 27127015 )
2016
13
Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. ( 27477534 )
2016
14
Scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: Management of this rare entity. ( 26298623 )
2015
15
Lamisil, a potent alternative antifungal drug for otomycosis. ( 28680976 )
2015
16
Otomycosis in Adolescent Patients Referred to the Therapeutic Centers in Babol City, Iran. ( 26060563 )
2015
17
Etiologic Agents of Otomycosis in the North-Western Area of Iran. ( 26495108 )
2015
18
Epidemiology, causative agents, and risk factors affecting human otomycosis infections. ( 26422852 )
2015
19
Otomycosis in Iran: A Review. ( 25633436 )
2015
20
Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis? ( 25621236 )
2015
21
Otomycosis in Jos: Predisposing factors and Management. ( 26690089 )
2014
22
Treatment of refractory Aspergillus otomycosis with voriconazole: case series and review. ( 24909800 )
2014
23
Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. ( 24949016 )
2014
24
Otomycosis; clinical features, predisposing factors and treatment implications. ( 24948980 )
2014
25
Efficacy of topical clotrimazole in treatment of otomycosis. ( 25098061 )
2013
26
Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ( 23984100 )
2013
27
Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents. ( 23595615 )
2013
28
Prevalence of otomycosis in Khouzestan Province, south-west Iran. ( 23164073 )
2013
29
Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. ( 21895787 )
2012
30
Otomycosis in immunocompetent and immunocompromised patients: comparative study and literature review. ( 22430336 )
2012
31
Otomycosis with Perforated Tympanic Membrane: Self medication with Topical Antifungal Solution versus Medicated Ear Wick. ( 23267306 )
2012
32
Molecular identification and antifungal susceptibilities of black Aspergillus isolates from otomycosis cases in Hungary. ( 22359155 )
2012
33
Otomycosis in Shanghai: aetiology, clinical features and therapy. ( 21999222 )
2012
34
Antibiotic resistance and otomycosis in the draining ear: culture results by diagnosis. ( 21041003 )
2011
35
A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis). ( 22529649 )
2011
36
Otomycosis due to filamentous fungi. ( 21499908 )
2011
37
Otomycosis in central iran: a clinical and mycological study. ( 22737432 )
2011
38
Chronic otomycosis due to malassezia spp. ( 20606976 )
2010
39
Prevalence of otomycosis in Ibadan: a review of laboratory reports. ( 22420052 )
2010
40
Otomycosis due to Aspergillus spp. in a dog: case report and literature review. ( 20492628 )
2010
41
Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus. ( 20409075 )
2010
42
Otomycosis: Diagnosis and treatment. ( 20347664 )
2010
43
Otomycosis: a retrospective study. ( 19649486 )
2009
44
Otomycosis in western Nigeria. ( 18076598 )
2008
45
Ototopical antifungals and otomycosis: a review. ( 18279975 )
2008
46
Aspergillus otomycosis in an immunocompromised patient. ( 19006061 )
2008
47
Outer limits. An overview of otomycosis. ( 20014678 )
2007
48
In vitro susceptibilities of Aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazole. ( 17944704 )
2007
49
Scedosporium apiospermum otomycosis. ( 17606042 )
2007
50
Suction clearance and 2% topical miconazole versus the same combination with acidic drops in the treatment of otomycosis. ( 17883017 )
2007

Variations for Otomycosis

Expression for Otomycosis

Search GEO for disease gene expression data for Otomycosis.

Pathways for Otomycosis

Pathways related to Otomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 CALM1 CALM2 CALM3 CD99 CXCL14
2
Show member pathways
13.19 CALM1 CALM2 CALM3 CD99 FLNA
3
Show member pathways
12.91 CALM1 CALM2 CALM3 FLNA
4
Show member pathways
12.76 CALM1 CALM2 CALM3 CXCL14
5
Show member pathways
12.48 CALM1 CALM2 CALM3
6
Show member pathways
12.4 CALM1 CALM2 CALM3
7
Show member pathways
12.39 CALM1 CALM2 CALM3
8
Show member pathways
12.34 CALM1 CALM2 CALM3
9
Show member pathways
12.33 CALM1 CALM2 CALM3
10
Show member pathways
12.31 CALM1 CALM2 CALM3
11
Show member pathways
12.29 CALM1 CALM2 CALM3
12
Show member pathways
12.29 CALM1 CALM2 CALM3
13
Show member pathways
12.28 CALM1 CALM2 CALM3
14
Show member pathways
12.27 CALM1 CALM2 CALM3 FLNA
15 12.26 CALM1 CALM2 CALM3
16
Show member pathways
12.25 CALM1 CALM2 CALM3
17
Show member pathways
12.24 CALM1 CALM2 CALM3
18
Show member pathways
12.23 CALM1 CALM2 CALM3
19
Show member pathways
12.23 CALM1 CALM2 CALM3
20
Show member pathways
12.22 CALM1 CALM2 CALM3
21
Show member pathways
12.2 CALM1 CALM2 CALM3
22
Show member pathways
12.16 CALM1 CALM2 CALM3
23
Show member pathways
12.16 CALM1 CALM2 CALM3
24
Show member pathways
12.15 CALM1 CALM2 CALM3
25
Show member pathways
12.15 CALM1 CALM2 CALM3
26 12.13 CALM1 CALM2 CALM3
27
Show member pathways
12.11 CALM1 CALM2 CALM3
28
Show member pathways
12.11 CALM1 CALM2 CALM3
29
Show member pathways
12.08 CALM1 CALM2 CALM3
30
Show member pathways
12.08 CALM1 CALM2 CALM3
31
Show member pathways
12.06 CALM1 CALM2 CALM3
32 12.06 CALM1 CALM2 CALM3
33
Show member pathways
12.04 CALM1 CALM2 CALM3
34
Show member pathways
12.03 CALM1 CALM2 CALM3
35 11.99 CALM1 CALM2 CALM3
36 11.98 CALM1 CALM2 CALM3
37
Show member pathways
11.92 CALM1 CALM2 CALM3
38
Show member pathways
11.91 CALM1 CALM2 CALM3
39
Show member pathways
11.88 CALM1 CALM2 CALM3
40
Show member pathways
11.85 CALM1 CALM2 CALM3
41 11.84 CALM1 CALM2 CALM3
42 11.83 CALM1 CALM2 CALM3
43 11.81 CALM1 CALM2 CALM3
44
Show member pathways
11.8 CALM1 CALM2 CALM3
45
Show member pathways
11.77 CALM1 CALM2 CALM3
46
Show member pathways
11.76 CALM1 CALM2 CALM3
47
Show member pathways
11.7 CALM1 CALM2 CALM3
48
Show member pathways
11.69 CALM1 CALM2 CALM3
49
Show member pathways
11.67 CALM1 CALM2 CALM3
50 11.66 CALM1 CALM2 CALM3

GO Terms for Otomycosis

Cellular components related to Otomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.58 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.54 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Otomycosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
2 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
3 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
4 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
7 positive regulation of protein autophosphorylation GO:0031954 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
12 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.63 CALM1 CALM2 CALM3
13 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
14 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.58 CALM1 CALM2 CALM3
15 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
16 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
17 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
18 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
19 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
20 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.65 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.62 CALM1 CALM2 CALM3 FLNA
3 disordered domain specific binding GO:0097718 9.58 CALM1 CALM2 CALM3
4 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
5 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
6 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
7 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
8 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
9 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3
10 protein binding GO:0005515 10.16 CALM1 CALM2 CALM3 CBS CD99 CXCL14

Sources for Otomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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