MCID: OTS003
MIFTS: 25

Otosalpingitis

Categories: Ear diseases

Aliases & Classifications for Otosalpingitis

MalaCards integrated aliases for Otosalpingitis:

Name: Otosalpingitis 12 15
Eustachian Tube Salpingitis 12 71
Eustachian Salpingitis 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2000
ICD9CM 34 381.5 381.50
SNOMED-CT 67 35349000
UMLS 71 C0155428

Summaries for Otosalpingitis

Disease Ontology : 12 A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube.

MalaCards based summary : Otosalpingitis, also known as eustachian tube salpingitis, is related to acute eustachian salpingitis and chronic eustachian salpingitis. An important gene associated with Otosalpingitis is SLC36A2 (Solute Carrier Family 36 Member 2), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. The drugs Anesthetics and Central Nervous System Depressants have been mentioned in the context of this disorder. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Otosalpingitis

Diseases related to Otosalpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 acute eustachian salpingitis 11.3
2 chronic eustachian salpingitis 11.3
3 salpingitis 10.4
4 otitis media 10.2
5 cholesteatoma of middle ear 10.2
6 eustachian tube disease 10.2 SLC36A2 INTU
7 rhinitis 10.2
8 mucopolysaccharidosis, type vi 10.0 LIG3 ARSB
9 central nervous system leukemia 9.9 CD34 CD19
10 blood protein disease 9.8 CD34 CD19
11 leukemia, acute lymphoblastic 3 9.8 CD34 CD19
12 combined t cell and b cell immunodeficiency 9.8 CD34 CD19
13 hemorrhagic cystitis 9.7 CSF3 CD34
14 capillary disease 9.7 CSF3 CD34
15 chronic neutrophilic leukemia 9.7 CSF3 CD34
16 hepatic vascular disease 9.7 CSF3 CD34
17 lymphatic system disease 9.7 CD34 CD19
18 adult lymphoma 9.7 CSF3 CD19
19 capillary leak syndrome 9.6 CSF3 CD19
20 exanthem 9.6 CSF3 CD19
21 metachromatic leukodystrophy 9.6 CD34 ARSB
22 appendicitis 9.5 CSF3 CD19
23 lymphatic system cancer 9.3 CSF3 CD34 CD19
24 blood coagulation disease 9.3 CSF3 CD34 CD19
25 bone marrow cancer 9.3 CSF3 CD34 CD19
26 blood platelet disease 9.3 CSF3 CD34 CD19
27 leukocyte disease 9.3 CSF3 CD34 CD19
28 pancytopenia 9.3 CSF3 CD34 CD19
29 severe combined immunodeficiency 9.2 CSF3 CD34 CD19
30 leukemia, acute lymphoblastic 9.2 CSF3 CD34 CD19
31 deficiency anemia 9.1 CSF3 CD34 CD19
32 myeloma, multiple 9.1 CSF3 CD34 CD19
33 leukemia, chronic myeloid 9.1 CSF3 CD34 CD19
34 hematologic cancer 9.0 CSF3 CD34 CD19
35 lymphoma, non-hodgkin, familial 8.9 CSF3 CD34 CD19

Graphical network of the top 20 diseases related to Otosalpingitis:



Diseases related to Otosalpingitis

Symptoms & Phenotypes for Otosalpingitis

GenomeRNAi Phenotypes related to Otosalpingitis according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.5 ARSB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.5 ARSB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.5 ARSB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.5 LIG3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.5 LIG3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.5 LIG3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.5 LIG3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.5 ARSB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.5 ARSB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.5 CSF3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.5 CSF3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.5 ARSB CSF3 LIG3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.5 LIG3

MGI Mouse Phenotypes related to Otosalpingitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.1 ARSB CD19 CD34 INTU LIG3 VASP

Drugs & Therapeutics for Otosalpingitis

Drugs for Otosalpingitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics
2 Central Nervous System Depressants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Feasibility of Balloon Dilation of the Eustachian Tubes for Dilatory Dysfunction Under Local Anesthesia Not yet recruiting NCT04055714

Search NIH Clinical Center for Otosalpingitis

Genetic Tests for Otosalpingitis

Anatomical Context for Otosalpingitis

Publications for Otosalpingitis

Articles related to Otosalpingitis:

(show all 15)
# Title Authors PMID Year
1
[Middle ear retraction-type disease. From otosalpingitis to cholesteatoma]. 61
9445937 1997
2
On the function of the mastoid cavity with emphasis on its role in middle ear defence. 61
9687646 1997
3
[Effects and adverse effects of decongestants in otosalpingitis]. 61
3537593 1986
4
[Follow-ups after otitis media in primary care. Every fourth patient shows signs of otosalpingitis a month after acute otitis media]. 61
6683347 1983
5
[Photographic documentation of the tympanic membrane of value in the diagnosis of acute otitis and otosalpingitis]. 61
6891735 1982
6
Tone audiometry control of children treated for meningitis with large intravenous doses of ampicillin. 61
1087098 1976
7
Atopic allergy and immunoglobulins in children with adenoids and recurrent otitis media. 61
961411 1976
8
The oxygen tension in transudate of the middle ear. 61
1171572 1975
9
[Middle-ear drainage in otosalpingitis]. 61
4636406 1972
10
[Otosalpingitis--treatment with a polyethylene tube in the ear drum]. 61
5074564 1972
11
[OTOSALPINGITIS]. 61
14108900 1964
12
Otosalpingitis and mastoid pneumatization. 61
13605716 1958
13
X-ray treatment of otosalpingitis. 61
13402449 1957
14
[The problem of otosalpingitis]. 61
13288827 1955
15
The eustachian tube; histological findings under normal conditions and in otosalpingitis. 61
13227981 1954

Variations for Otosalpingitis

Expression for Otosalpingitis

Search GEO for disease gene expression data for Otosalpingitis.

Pathways for Otosalpingitis

Pathways related to Otosalpingitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 CSF3 CD34 CD19
2 11.13 CD34 CD19
3 10.88 CD34 CD19
4 10.79 CSF3 CD34 CD19

GO Terms for Otosalpingitis

Biological processes related to Otosalpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron death GO:1901215 8.96 CSF3 CD34
2 positive regulation of actin filament polymerization GO:0030838 8.62 VASP CSF3

Sources for Otosalpingitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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