Otosalpingitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Otosalpingitis

MalaCards integrated aliases for Otosalpingitis:

Name: Otosalpingitis ¹² ¹⁵

Eustachian Tube Salpingitis ¹² ⁷¹

Eustachian Salpingitis ¹² ³²

Classifications:

MalaCards categories:
Anatomical: Ear diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the ear and mastoid process

Diseases of middle ear and mastoid

Eustachian salpingitis and obstruction

Eustachian salpingitis

External Ids:

Disease Ontology ¹² DOID:2000

ICD9CM ³⁴ 381.5

SNOMED-CT ⁶⁷ 270491006

ICD10 ³² H68.0

UMLS ⁷¹ C0155428

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Summaries for Otosalpingitis

Disease Ontology : ¹² A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube.

MalaCards based summary : Otosalpingitis, also known as eustachian tube salpingitis, is related to acute eustachian salpingitis and chronic eustachian salpingitis. An important gene associated with Otosalpingitis is SLC36A2 (Solute Carrier Family 36 Member 2). The drug Anesthetics has been mentioned in the context of this disorder. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Otosalpingitis

Diseases related to Otosalpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)

#	Related Disease	Score	Top Affiliating Genes
1	acute eustachian salpingitis	11.3
2	chronic eustachian salpingitis	11.3
3	salpingitis	10.4
4	otitis media	10.3
5	cholesteatoma of middle ear	10.3
6	eustachian tube disease	10.2	SLC36A2 INTU
7	rhinitis	10.2
8	mucopolysaccharidosis, type vi	10.0	LIG3 ARSB
9	lipodystrophy, familial partial, type 5	9.8	PSMB8 LIPE
10	anauxetic dysplasia 1	9.6	CSF3 CD19
11	adult lymphoma	9.6	CSF3 CD19
12	hemorrhagic cystitis	9.6	CSF3 CD19
13	cd40 ligand deficiency	9.5	CSF3 CD19
14	panniculitis	9.4	PSMB8 CSF3
15	adult acute lymphocytic leukemia	9.4	CSF3 CD19
16	appendicitis	9.2	CSF3 CD19

Graphical network of the top 20 diseases related to Otosalpingitis:

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Symptoms & Phenotypes for Otosalpingitis

GenomeRNAi Phenotypes related to Otosalpingitis according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.47	ARSB CSF3
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	9.47	ARSB
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.47	ARSB
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.47	ARSB
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	9.47	LIG3
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	9.47	CSF3
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-204	9.47	CSF3
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-27	9.47	ARSB
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.47	ARSB
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.47	CSF3 LIG3
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.47	LIG3
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.47	LIG3

MGI Mouse Phenotypes related to Otosalpingitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	9.02	ARSB CD19 CSF3 DBT INTU

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Drugs & Therapeutics for Otosalpingitis

Drugs for Otosalpingitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Anesthetics

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Feasibility of Balloon Dilation of the Eustachian Tubes for Dilatory Dysfunction Under Local Anesthesia	Not yet recruiting	NCT04055714

Search NIH Clinical Center for Otosalpingitis

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Genetic Tests for Otosalpingitis

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Anatomical Context for Otosalpingitis

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Publications for Otosalpingitis

Articles related to Otosalpingitis:

(show all 15)

#	Title	Authors	PMID	Year
1	[Middle ear retraction-type disease. From otosalpingitis to cholesteatoma]. ⁶¹	Magnuson B...Harder H	9445937	1997
2	On the function of the mastoid cavity with emphasis on its role in middle ear defence. ⁶¹	Radovic N...Hyden D	9687646	1997
3	[Effects and adverse effects of decongestants in otosalpingitis]. ⁶¹	Fabian P...Melander H	3537593	1986
4	[Follow-ups after otitis media in primary care. Every fourth patient shows signs of otosalpingitis a month after acute otitis media]. ⁶¹	Larsson G	6683347	1983
5	[Photographic documentation of the tympanic membrane of value in the diagnosis of acute otitis and otosalpingitis]. ⁶¹	Aberg B	6891735	1982
6	Tone audiometry control of children treated for meningitis with large intravenous doses of ampicillin. ⁶¹	Dahnsjo H...Rudberg RD	1087098	1976
7	Atopic allergy and immunoglobulins in children with adenoids and recurrent otitis media. ⁶¹	Kjellman NI...Hansson LO	961411	1976
8	The oxygen tension in transudate of the middle ear. ⁶¹	Drettner B	1171572	1975
9	[Middle-ear drainage in otosalpingitis]. ⁶¹	von Sydow C	4636406	1972
10	[Otosalpingitis--treatment with a polyethylene tube in the ear drum]. ⁶¹	Stangeland N	5074564	1972
11	[OTOSALPINGITIS]. ⁶¹	LYSTAD HB	14108900	1964
12	Otosalpingitis and mastoid pneumatization. ⁶¹	DIAMANT M...WALANDER A	13605716	1958
13	X-ray treatment of otosalpingitis. ⁶¹	ASCHAN G...NOHRMAN B	13402449	1957
14	[The problem of otosalpingitis]. ⁶¹	LUNDBORG T	13288827	1955
15	The eustachian tube; histological findings under normal conditions and in otosalpingitis. ⁶¹	ASCHAN G	13227981	1954

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Genes for Otosalpingitis

Genes related to Otosalpingitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLC36A2	Solute Carrier Family 36 Member 2	Protein Coding	7.38	DISEASES inferred ¹⁵
2	INTU	Inturned Planar Cell Polarity Protein	Protein Coding	5.85	DISEASES inferred ¹⁵
3	DBT	Dihydrolipoamide Branched Chain Transacylase E2	Protein Coding	5.46	DISEASES inferred ¹⁵
4	ARSB	Arylsulfatase B	Protein Coding	5	DISEASES inferred ¹⁵
5	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	4.63	DISEASES inferred ¹⁵
6	LIG3	DNA Ligase 3	Protein Coding	4.53	DISEASES inferred ¹⁵
7	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	4.47	DISEASES inferred ¹⁵
8	PDE5A	Phosphodiesterase 5A	Protein Coding	4.23	DISEASES inferred ¹⁵
9	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	3.89	DISEASES inferred ¹⁵
10	CSF3	Colony Stimulating Factor 3	Protein Coding	3.43	DISEASES inferred ¹⁵
11	CD19	CD19 Molecule	Protein Coding	3.41	DISEASES inferred ¹⁵

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Variations for Otosalpingitis

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Expression for Otosalpingitis

Search GEO for disease gene expression data for Otosalpingitis.

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Pathways for Otosalpingitis

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GO Terms for Otosalpingitis

Biological processes related to Otosalpingitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of actin filament polymerization	GO:0030838	8.62	VASP CSF3

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Sources for Otosalpingitis

¹ BioSystems

² BitterDB

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

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²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶⁷ SNOMED-CT

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⁶⁹ TGDB

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⁷¹ UMLS

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⁷⁴ Wikipedia