OUBR
MCID: OBN001
MIFTS: 15

Ouabain Resistance (OUBR)

Aliases & Classifications for Ouabain Resistance

MalaCards integrated aliases for Ouabain Resistance:

Name: Ouabain Resistance 57
Oubr 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
x-linked


HPO:

31
ouabain resistance:
Inheritance x-linked inheritance


External Ids:

OMIM® 57 311350
SNOMED-CT via HPO 68 263934009

Summaries for Ouabain Resistance

MalaCards based summary : Ouabain Resistance, also known as oubr, is related to fibrosarcoma. An important gene associated with Ouabain Resistance is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). Affiliated tissues include ovary, lung and liver.

More information from OMIM: 311350

Related Diseases for Ouabain Resistance

Diseases related to Ouabain Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fibrosarcoma 9.9

Symptoms & Phenotypes for Ouabain Resistance

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Misc:
ouabain resistance cellular phenotype

Clinical features from OMIM®:

311350 (Updated 05-Apr-2021)

Drugs & Therapeutics for Ouabain Resistance

Search Clinical Trials , NIH Clinical Center for Ouabain Resistance

Genetic Tests for Ouabain Resistance

Anatomical Context for Ouabain Resistance

MalaCards organs/tissues related to Ouabain Resistance:

40
Ovary, Lung, Liver, Brain, Kidney, T Cells

Publications for Ouabain Resistance

Articles related to Ouabain Resistance:

(show top 50) (show all 204)
# Title Authors PMID Year
1
Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. 57 61
2823111 1987
2
Molecular cloning of the mouse ouabain-resistance gene. 61 57
6324196 1984
3
Isolation of diploid human lymphoblast mutants presumably homozygous for ouabain resistance. 61 57
6244579 1980
4
Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids. 61 57
454358 1979
5
Isolation of ouabain-resistant human diploid fibroblasts. 57
4434471 1974
6
Finite cell lines of turkey sperm storage tubule cells: ultrastructure and protein analysis. 61
29860518 2018
7
Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of Drosophila subobscura. 61
27029337 2016
8
Targeted mutations in the Na,K-ATPase α 2 isoform confer ouabain resistance and result in abnormal behavior in mice. 61
20936682 2011
9
Anomalous genotoxic responses induced in mouse lymphoma L5178Y cells by potassium bromate. 61
19853637 2010
10
RAD51D- and FANCG-dependent base substitution mutagenesis at the ATP1A1 locus in mammalian cells. 61
19427512 2009
11
BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations. 61
18413724 2008
12
Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability. 61
18192872 2008
13
HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses. 61
17066413 2006
14
Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. 61
12509447 2003
15
Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3. 61
12093470 2002
16
Enhanced ouabain resistance gene as a eukaryotic selection marker. 61
12031129 2002
17
Hypermutable change of human UV(r)-1 cells by p53 overexpression. 61
11726213 2001
18
Ouabain resistance of a human trophoblast cell line is not related to its reactivity to ouabain. 61
11089925 2000
19
The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. 61
10555956 1999
20
Domain swapping between Na,K- and H,K-ATPase identifies regions that specify Na,K-ATPase activity. 61
9585565 1998
21
The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size. 61
9395226 1997
22
Mutator phenotype in Msh2-deficient murine embryonic fibroblasts. 61
9288785 1997
23
Extensive random mutagenesis analysis of the Na+/K+-ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity--implications for ouabain binding. 61
9346307 1997
24
Cold- and ouabain-resistance of renal Na,K-ATPase in cold-exposed and hibernating jerboas (Jaculus orientalis). 61
9219354 1997
25
Localization of cytoplasmic and extracellular domains of Na,K-ATPase by epitope tag insertion. 61
8916902 1996
26
Critical effects on catalytic function produced by amino acid substitutions at Asp804 and Asp808 of the alpha1 isoform of Na,K-ATPase. 61
8766825 1996
27
Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools. 61
7563070 1995
28
Ouabain resistance of the epithelial cell line (Ma104) is not due to lack of affinity of its pumps for the drug. 61
7563030 1995
29
Functional consequences of substitutions of the carboxyl residue glutamate 779 of the Na,K-ATPase. 61
7550450 1995
30
Mutant Glu781-->Ala of the rat kidney Na+,K(+)-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions. 61
7827094 1995
31
Induction of mutation, sister-chromatid exchanges, and chromosome aberrations by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in Chinese hamster ovary cells. 61
7523875 1994
32
Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds. 61
7843085 1994
33
Ouabain-resistant OR6 cells express the murine alpha 1-subunit of the Na,K-ATPase with a T797-I797 substitution. 61
8195174 1994
34
Analysis of amino acid residues in the H5-H6 transmembrane and extracellular domains of Na,K-ATPase alpha subunit identifies threonine 797 as a determinant of ouabain sensitivity. 61
8155637 1994
35
Site-directed mutagenesis of the Na,K-ATPase: consequences of substitutions of negatively-charged amino acids localized in the transmembrane domains. 61
8257687 1993
36
Random mutagenesis of the sheep Na,K-ATPase alpha-1 subunit generates a novel T797N mutation that results in a ouabain-resistant enzyme. 61
8244998 1993
37
Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance. 61
8394348 1993
38
Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). 61
8330360 1993
39
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. 61
8382694 1993
40
Increased spontaneous mutation rates and prevalence of karyotype abnormalities in highly metastatic human melanoma cell lines. 61
8471837 1993
41
Quantitative relationship between ethylated DNA bases and gene mutation at two loci in CHO cells. 61
8383034 1993
42
Nonpolar amino acid substitutions of potential cation binding residues glu-955 and glu-956 of the rat alpha 1 isoform of Na+, K(+)-ATPase. 61
8173592 1993
43
Substitution of transmembrane residues with hydrogen-bonding potential in the alpha subunit of Na,K-ATPase reveals alterations in ouabain sensitivity. 61
7678498 1993
44
Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes. 61
1454799 1992
45
How extracellular potassium affects intracellular sodium pool in human erythrocytes. 61
1332719 1992
46
Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump. 61
1380956 1992
47
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. 61
1324928 1992
48
Application of the standard mutagenesis assay results in underestimation of ethyl methanesulphonate-induced mutations to ouabain-resistance in Chinese hamster cells. 61
1374155 1992
49
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. 61
1316269 1992
50
Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells. 61
1653250 1991

Variations for Ouabain Resistance

Expression for Ouabain Resistance

Search GEO for disease gene expression data for Ouabain Resistance.

Pathways for Ouabain Resistance

GO Terms for Ouabain Resistance

Sources for Ouabain Resistance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....