OUBR
MCID: OBN001
MIFTS: 16

Ouabain Resistance (OUBR)

Aliases & Classifications for Ouabain Resistance

MalaCards integrated aliases for Ouabain Resistance:

Name: Ouabain Resistance 58
Oubr 58

Characteristics:

OMIM:

58
Inheritance:
x-linked


HPO:

33
ouabain resistance:
Inheritance x-linked inheritance


External Ids:

OMIM 58 311350
MedGen 43 C1839502
SNOMED-CT via HPO 70 263934009

Summaries for Ouabain Resistance

MalaCards based summary : Ouabain Resistance, also known as oubr, is related to overhydrated hereditary stomatocytosis and retinoblastoma. An important gene associated with Ouabain Resistance is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). Affiliated tissues include testes and t cells.

Description from OMIM: 311350

Related Diseases for Ouabain Resistance

Diseases related to Ouabain Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 overhydrated hereditary stomatocytosis 11.3
2 retinoblastoma 10.1
3 lymphoma 10.1
4 lithium transport 9.9
5 small cell cancer of the lung 9.9
6 lung cancer 9.9

Graphical network of the top 20 diseases related to Ouabain Resistance:



Diseases related to Ouabain Resistance

Symptoms & Phenotypes for Ouabain Resistance

Symptoms via clinical synopsis from OMIM:

58
Misc:
ouabain resistance cellular phenotype

Clinical features from OMIM:

311350

Drugs & Therapeutics for Ouabain Resistance

Search Clinical Trials , NIH Clinical Center for Ouabain Resistance

Genetic Tests for Ouabain Resistance

Anatomical Context for Ouabain Resistance

MalaCards organs/tissues related to Ouabain Resistance:

42
Testes, T Cells

Publications for Ouabain Resistance

Articles related to Ouabain Resistance:

(show all 43)
# Title Authors Year
1
Targeted mutations in the Na,K-ATPase α 2 isoform confer ouabain resistance and result in abnormal behavior in mice. ( 20936682 )
2011
2
Enhanced ouabain resistance gene as a eukaryotic selection marker. ( 12031129 )
2002
3
Ouabain resistance of a human trophoblast cell line is not related to its reactivity to ouabain. ( 11089925 )
2000
4
Cold- and ouabain-resistance of renal Na,K-ATPase in cold-exposed and hibernating jerboas (Jaculus orientalis). ( 9219354 )
1997
5
The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size. ( 9395226 )
1997
6
Ouabain resistance of the epithelial cell line (Ma104) is not due to lack of affinity of its pumps for the drug. ( 7563030 )
1995
7
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. ( 8382694 )
1993
8
Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance. ( 8394348 )
1993
9
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. ( 1316269 )
1992
10
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. ( 1324928 )
1992
11
Application of the standard mutagenesis assay results in underestimation of ethyl methanesulphonate-induced mutations to ouabain-resistance in Chinese hamster cells. ( 1374155 )
1992
12
A statistical evaluation of the reproducibility of micronucleus, sister-chromatid exchange, thioguanine-resistance and ouabain-resistance assays in V79 cells exposed to ethyl methanesulfonate and 7,12-dimethylbenz[a]anthracene. ( 2109193 )
1990
13
Induction of ouabain-resistance mutation and cycle-dependent transformation of C3H/10T1/2 cells by N-nitroso-2-acetylaminofluorene. ( 2342496 )
1990
14
CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids. ( 2826456 )
1988
15
Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. ( 2823111 )
1987
16
Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. ( 3039660 )
1987
17
Reduced ouabain inhibition of Na,K-activated adenosine triphosphatase in cultured cell recipients of the ouabain-resistance gene. ( 3015906 )
1986
18
Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. ( 2981832 )
1985
19
Mutagenesis at the ouabain-resistance locus of 3.7.2C L5178Y cells by chromosomal mutagens. ( 2996875 )
1985
20
Chromosome-mediated transfer of murine alleles for hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and ouabain resistance into human cell lines. ( 3994653 )
1985
21
Molecular cloning of the mouse ouabain-resistance gene. ( 6324196 )
1984
22
Suppressive action of near-ultraviolet light on ouabain resistance induced by far-ultraviolet light in Chinese hamster cells. ( 6828075 )
1983
23
Microcell-mediated transfer of carcinogen-induced ouabain resistance from C3H/10T1/2 Cl 8 mouse fibroblasts to human cells. ( 6865991 )
1983
24
Evaluation of a mutation test using S49 mouse lymphoma cells and monitoring simultaneously the induction of dexamethasone resistance, 6-thioguanine resistance and ouabain resistance. ( 6865994 )
1983
25
Measurement of spontaneous mutation rates at the Na+/K+ ATPase locus (ouabain resistance) of human fibroblasts using improved growth conditions. ( 6292710 )
1982
26
Induction of ouabain resistance in V-79 cells by four carbamate pesticides. ( 6814905 )
1982
27
Thioguanine resistance, ouabain resistance and sister chromatid exchanges in V79/AP4 Chinese hamster cells treated with potassium dichromate. ( 6891292 )
1982
28
Differential cell cycle phase specificity for neoplastic transformation and mutation to ouabain resistance induced by N-methyl-N'-nitro-N-nitrosoguanidine in synchronized C3H10T 1/2 C18 cells. ( 6956864 )
1982
29
Relative sensitivity of V79 and V79/79 cells to spontaneous and induced mutation to 6-thioguanine and ouabain resistance. ( 7121489 )
1982
30
Competence for DNA transfer of ouabain resistance and thymidine kinase: clonal variation in mouse L-cell recipients. ( 7292261 )
1981
31
Isolation of diploid human lymphoblast mutants presumably homozygous for ouabain resistance. ( 6244579 )
1980
32
The tumour promoter TPA does not affect mutation to ouabain resistance in L5178Y mouse lymphoma cells. ( 11219839 )
1980
33
Induction of mutation to ouabain resistance and of malignant transformation by chemicals in cloned mouse M2 fibroblasts. ( 22283002 )
1980
34
Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts. ( 284417 )
1979
35
Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids. ( 454358 )
1979
36
Granuloma pouch assay. I. Induction of ouabain resistance by MNNG in vivo. ( 362187 )
1978
37
Mutation to ouabain-resistance in Chinese hamster cells: induction by ethyl methanesulphonate and lack of induction by ionising radiation. ( 692542 )
1978
38
Gene expression in euploid human hybrid cells: ouabain resistance is codominant. ( 694727 )
1978
39
Bromodeoxyuridine-induced mutations in synchronous Chinese hamster cells: temporal induction of 6-thioguanine and ouabain resistance during DNA replication. ( 730050 )
1978
40
Contact-mediated communication of ouabain resistance in mammalian cells in culture. ( 561315 )
1977
41
Mutagenesis at the ouabain-resistance locus in human diploid fibroblasts. ( 904650 )
1977
42
Effect of ouabain resistance on human diploid fibroblasts carrying other genetic variants. ( 172346 )
1975
43
A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells. ( 1240591 )
1975

Variations for Ouabain Resistance

Expression for Ouabain Resistance

Search GEO for disease gene expression data for Ouabain Resistance.

Pathways for Ouabain Resistance

GO Terms for Ouabain Resistance

Sources for Ouabain Resistance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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