Aliases & Classifications for Ouabain Resistance

MalaCards integrated aliases for Ouabain Resistance:

Name: Ouabain Resistance 57
Oubr 57

Characteristics:

OMIM:

57
Inheritance:
x-linked


HPO:

32
ouabain resistance:
Inheritance x-linked inheritance


External Ids:

OMIM 57 311350
MedGen 42 C1839502
SNOMED-CT via HPO 69 263934009

Summaries for Ouabain Resistance

MalaCards based summary : Ouabain Resistance, also known as oubr, is related to overhydrated hereditary stomatocytosis and lithium transport. An important gene associated with Ouabain Resistance is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). Affiliated tissues include t cells and lung.

Description from OMIM: 311350

Related Diseases for Ouabain Resistance

Diseases related to Ouabain Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 overhydrated hereditary stomatocytosis 11.1
2 lithium transport 9.8
3 small cell cancer of the lung 9.8
4 lung cancer 9.8
5 lymphoma 9.8

Graphical network of the top 20 diseases related to Ouabain Resistance:



Diseases related to Ouabain Resistance

Symptoms & Phenotypes for Ouabain Resistance

Symptoms via clinical synopsis from OMIM:

57
Misc:
ouabain resistance cellular phenotype


Clinical features from OMIM:

311350

Drugs & Therapeutics for Ouabain Resistance

Search Clinical Trials , NIH Clinical Center for Ouabain Resistance

Genetic Tests for Ouabain Resistance

Anatomical Context for Ouabain Resistance

MalaCards organs/tissues related to Ouabain Resistance:

41
T Cells, Lung

Publications for Ouabain Resistance

Articles related to Ouabain Resistance:

(show all 28)
# Title Authors Year
1
Targeted mutations in the Na,K-ATPase I+ 2 isoform confer ouabain resistance and result in abnormal behavior in mice. ( 20936682 )
2011
2
Regulation of renal ouabain-resistant Na+-ATPase by leptin, nitric oxide, reactive oxygen species, and cyclic nucleotides: implications for obesity-associated hypertension. ( 17497345 )
2007
3
Enhanced ouabain resistance gene as a eukaryotic selection marker. ( 12031129 )
2002
4
Ouabain resistance of a human trophoblast cell line is not related to its reactivity to ouabain. ( 11089925 )
2000
5
Participation of Na,K-ATPase in FGF-2 secretion: rescue of ouabain-inhibitable FGF-2 secretion by ouabain-resistant Na,K-ATPase alpha subunits. ( 11101303 )
2000
6
The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. ( 10555956 )
1999
7
The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size. ( 9395226 )
1997
8
Cold- and ouabain-resistance of renal Na,K-ATPase in cold-exposed and hibernating jerboas (Jaculus orientalis). ( 9219354 )
1997
9
Ouabain resistance of the epithelial cell line (Ma104) is not due to lack of affinity of its pumps for the drug. ( 7563030 )
1995
10
Ouabain-resistant non-small-cell lung-cancer cell line shows collateral sensitivity to cis-diamminedichloroplatinum(II) (CDDP). ( 8150528 )
1994
11
Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance. ( 8394348 )
1993
12
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. ( 8382694 )
1993
13
Application of the standard mutagenesis assay results in underestimation of ethyl methanesulphonate-induced mutations to ouabain-resistance in Chinese hamster cells. ( 1374155 )
1992
14
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. ( 1316269 )
1992
15
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. ( 1324928 )
1992
16
Development and characterization of ouabain-resistant human fusion partners. ( 1655911 )
1991
17
Induction of ouabain-resistance mutation and cycle-dependent transformation of C3H/10T1/2 cells by N-nitroso-2-acetylaminofluorene. ( 2342496 )
1990
18
A statistical evaluation of the reproducibility of micronucleus, sister-chromatid exchange, thioguanine-resistance and ouabain-resistance assays in V79 cells exposed to ethyl methanesulfonate and 7,12-dimethylbenz[a]anthracene. ( 2109193 )
1990
19
Sodium transport defect of ouabain-resistant renal Na,K-ATPase. ( 2556141 )
1989
20
CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids. ( 2826456 )
1988
21
Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. ( 3039660 )
1987
22
Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. ( 2823111 )
1987
23
Molecular analysis of ouabain-resistant mutants of the mouse lymphoma cell line L5178Y. ( 2830454 )
1987
24
Reduced ouabain inhibition of Na,K-activated adenosine triphosphatase in cultured cell recipients of the ouabain-resistance gene. ( 3015906 )
1986
25
Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. ( 2981832 )
1985
26
Chromosome-mediated transfer of murine alleles for hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and ouabain resistance into human cell lines. ( 3994653 )
1985
27
Mutagenesis at the ouabain-resistance locus of 3.7.2C L5178Y cells by chromosomal mutagens. ( 2996875 )
1985
28
Studies on lithium transport across the red cell membrane. VI. Properties of a sulfhydryl group involved in ouabain-resistant Na+-Li+ (and Na+-Na+) exchange in human and bovine erythrocytes. ( 231659 )
1979

Variations for Ouabain Resistance

Expression for Ouabain Resistance

Search GEO for disease gene expression data for Ouabain Resistance.

Pathways for Ouabain Resistance

GO Terms for Ouabain Resistance

Sources for Ouabain Resistance

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